VPS50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.90161268
2presynaptic membrane organization (GO:0097090)4.55767331
3gamma-aminobutyric acid transport (GO:0015812)4.54987655
4neuron cell-cell adhesion (GO:0007158)4.13193442
5neural tube formation (GO:0001841)4.03952838
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.94624716
7ionotropic glutamate receptor signaling pathway (GO:0035235)3.90813046
8postsynaptic membrane organization (GO:0001941)3.85658312
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.84890756
10response to pheromone (GO:0019236)3.82912101
11pyrimidine nucleobase catabolic process (GO:0006208)3.75096263
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.74821714
13vocalization behavior (GO:0071625)3.74412872
14glutamate receptor signaling pathway (GO:0007215)3.68482601
15primary amino compound metabolic process (GO:1901160)3.67124613
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.63462219
17startle response (GO:0001964)3.62302368
18cerebral cortex radially oriented cell migration (GO:0021799)3.56806613
19protein localization to synapse (GO:0035418)3.55042032
20piRNA metabolic process (GO:0034587)3.53180653
21righting reflex (GO:0060013)3.52417446
22indolalkylamine metabolic process (GO:0006586)3.51940016
23synaptic transmission, glutamatergic (GO:0035249)3.45452789
24negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42204668
25prenylation (GO:0097354)3.42155890
26protein prenylation (GO:0018342)3.42155890
27nucleobase catabolic process (GO:0046113)3.40487343
28Golgi to endosome transport (GO:0006895)3.38957892
29regulation of glutamate receptor signaling pathway (GO:1900449)3.38297893
30neuron-neuron synaptic transmission (GO:0007270)3.35400384
31cellular ketone body metabolic process (GO:0046950)3.21346436
32neuronal action potential propagation (GO:0019227)3.21198474
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.20734288
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19704773
35detection of calcium ion (GO:0005513)3.16018554
36C4-dicarboxylate transport (GO:0015740)3.15760778
37regulation of meiosis I (GO:0060631)3.14859674
38synaptic vesicle docking involved in exocytosis (GO:0016081)3.05810322
39behavioral response to nicotine (GO:0035095)3.01663658
40regulation of sarcomere organization (GO:0060297)3.01401819
41indole-containing compound metabolic process (GO:0042430)3.01059657
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.00687329
43neurotransmitter-gated ion channel clustering (GO:0072578)2.99695192
44transmission of nerve impulse (GO:0019226)2.98828568
45regulation of synaptic vesicle exocytosis (GO:2000300)2.98337827
46L-amino acid import (GO:0043092)2.98308654
47ketone body metabolic process (GO:1902224)2.96673378
48glutamate secretion (GO:0014047)2.96544597
49neuron recognition (GO:0008038)2.95923356
50tryptophan metabolic process (GO:0006568)2.95697228
51superoxide anion generation (GO:0042554)2.95571362
52axonal fasciculation (GO:0007413)2.94585621
53regulation of synapse maturation (GO:0090128)2.93614861
54G-protein coupled receptor internalization (GO:0002031)2.92375791
55negative regulation of mast cell activation (GO:0033004)2.91396883
56positive regulation of neurotransmitter secretion (GO:0001956)2.90615287
57regulation of excitatory postsynaptic membrane potential (GO:0060079)2.89664674
58water-soluble vitamin biosynthetic process (GO:0042364)2.85471303
59synaptic vesicle exocytosis (GO:0016079)2.83796737
60negative regulation of neurotransmitter transport (GO:0051589)2.83429751
61protein K11-linked deubiquitination (GO:0035871)2.83163241
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83126497
63long-chain fatty acid biosynthetic process (GO:0042759)2.82198173
64retinal cone cell development (GO:0046549)2.81371883
65serotonin receptor signaling pathway (GO:0007210)2.80136865
66synaptic vesicle maturation (GO:0016188)2.79315299
67positive regulation of mitochondrial fission (GO:0090141)2.79165395
68mechanosensory behavior (GO:0007638)2.78704249
69regulation of synapse assembly (GO:0051963)2.77467871
70cornea development in camera-type eye (GO:0061303)2.77121294
71response to auditory stimulus (GO:0010996)2.76645626
72positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.75582818
73regulation of postsynaptic membrane potential (GO:0060078)2.74888328
74central nervous system projection neuron axonogenesis (GO:0021952)2.70956796
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69874542
76long-term synaptic potentiation (GO:0060291)2.68836918
77male meiosis I (GO:0007141)2.68505573
78regulation of DNA endoreduplication (GO:0032875)2.68283728
79dendritic spine morphogenesis (GO:0060997)2.67741287
80regulation of neurotransmitter uptake (GO:0051580)2.67338308
81synapse assembly (GO:0007416)2.67238355
82positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67076336
83proline transport (GO:0015824)2.66890909
84behavioral response to ethanol (GO:0048149)2.65395673
85reflex (GO:0060004)2.64862358
86centriole assembly (GO:0098534)2.63951921
87negative regulation of systemic arterial blood pressure (GO:0003085)2.63111172
88regulation of dendritic spine morphogenesis (GO:0061001)2.61800097
89membrane depolarization during action potential (GO:0086010)2.60081435
90positive regulation of synapse assembly (GO:0051965)2.60060405
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.59800828
92regulation of synaptic vesicle transport (GO:1902803)2.59738588
93cAMP catabolic process (GO:0006198)2.58699554
94regulation of neurotransmitter secretion (GO:0046928)2.58664995
95synaptic vesicle endocytosis (GO:0048488)2.57587283
96fucose catabolic process (GO:0019317)2.57569164
97L-fucose metabolic process (GO:0042354)2.57569164
98L-fucose catabolic process (GO:0042355)2.57569164
99regulation of dendritic spine development (GO:0060998)2.56696651
100regulation of action potential (GO:0098900)2.56332687
101cyclic nucleotide catabolic process (GO:0009214)2.56258067
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55465730
103neuronal action potential (GO:0019228)2.55201856
104regulation of neuronal synaptic plasticity (GO:0048168)2.55090843
105regulation of long-term neuronal synaptic plasticity (GO:0048169)2.53420238
106regulation of acyl-CoA biosynthetic process (GO:0050812)2.53056644
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.52190776
108detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51207342
109negative regulation of DNA-dependent DNA replication (GO:2000104)2.49877934
110positive regulation of cardiac muscle hypertrophy (GO:0010613)2.48463911
111positive regulation of muscle hypertrophy (GO:0014742)2.48463911
112regulation of glucokinase activity (GO:0033131)2.47396057
113regulation of hexokinase activity (GO:1903299)2.47396057
114cerebellar Purkinje cell differentiation (GO:0021702)2.47207175
115central nervous system neuron axonogenesis (GO:0021955)2.47184211
116glial cell proliferation (GO:0014009)2.47182895
117phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.47080327
118magnesium ion transport (GO:0015693)2.46443267
119epithelial cell differentiation involved in kidney development (GO:0035850)2.46143017
120DNA double-strand break processing (GO:0000729)2.45417126
121DNA methylation involved in gamete generation (GO:0043046)2.45276656
122protein targeting to vacuole (GO:0006623)2.44416324
123protein targeting to lysosome (GO:0006622)2.44416324
124establishment of protein localization to vacuole (GO:0072666)2.44416324
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43179359
126regulation of respiratory system process (GO:0044065)2.42111905
127regulation of synapse organization (GO:0050807)2.41893022
128regulation of inositol phosphate biosynthetic process (GO:0010919)2.41832374
129dendrite development (GO:0016358)2.41691519
130regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.41381571
131glycerophospholipid catabolic process (GO:0046475)2.41329604
132centriole replication (GO:0007099)2.40973885
133learning (GO:0007612)2.40853776
134monoubiquitinated protein deubiquitination (GO:0035520)2.40817773
135adult walking behavior (GO:0007628)2.40208184
136serotonin metabolic process (GO:0042428)2.40053975
137detection of light stimulus involved in visual perception (GO:0050908)2.39971260
138detection of light stimulus involved in sensory perception (GO:0050962)2.39971260
139locomotory exploration behavior (GO:0035641)2.39507535
140protein localization to cilium (GO:0061512)2.38617469
141positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.37480457
142positive regulation of cardiac muscle cell differentiation (GO:2000727)2.37178779
143dendrite morphogenesis (GO:0048813)2.37092521
144macroautophagy (GO:0016236)2.36553301
145neuronal ion channel clustering (GO:0045161)2.36326644
146membrane depolarization (GO:0051899)2.36261705
147regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.36158190
148regulation of vesicle fusion (GO:0031338)2.36154714
149protein import into peroxisome matrix (GO:0016558)2.35823066
150interkinetic nuclear migration (GO:0022027)2.34960204
151protein polyglutamylation (GO:0018095)2.34607332
152exploration behavior (GO:0035640)2.34514784
153positive regulation of meiosis (GO:0045836)2.34314584
154long-term memory (GO:0007616)2.33980985
155auditory behavior (GO:0031223)2.33758078
156nucleus localization (GO:0051647)2.33231664
157negative regulation of transcription regulatory region DNA binding (GO:2000678)2.33053674
158opioid receptor signaling pathway (GO:0038003)2.32555620
159establishment of protein localization to Golgi (GO:0072600)2.32313302
160regulation of synaptic plasticity (GO:0048167)2.32295189
161regulation of respiratory gaseous exchange (GO:0043576)2.32070615
162response to histamine (GO:0034776)2.31445720
163dendritic spine organization (GO:0097061)2.31428170
164positive regulation of neurotransmitter transport (GO:0051590)2.30361708
165regulation of glutamate secretion (GO:0014048)2.28985127
166dentate gyrus development (GO:0021542)2.28078237
167regulation of Rac GTPase activity (GO:0032314)2.27777837
168regulation of synaptic transmission, GABAergic (GO:0032228)2.27595514
169regulation of neurotransmitter transport (GO:0051588)2.26828944
170calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.25833252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.45609201
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.30280693
3EZH2_22144423_ChIP-Seq_EOC_Human3.80244457
4ZNF274_21170338_ChIP-Seq_K562_Hela2.89288122
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77718074
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.41461208
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.38207476
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37860396
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35874178
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35776178
11IGF1R_20145208_ChIP-Seq_DFB_Human2.30237975
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.29922936
13TAF15_26573619_Chip-Seq_HEK293_Human2.10237333
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08587918
15FUS_26573619_Chip-Seq_HEK293_Human2.07494882
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.05345467
17SUZ12_27294783_Chip-Seq_NPCs_Mouse2.01108357
18P300_19829295_ChIP-Seq_ESCs_Human1.99881273
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99487359
20TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.97658552
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96871896
22NANOG_18555785_Chip-Seq_ESCs_Mouse1.95700356
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93408064
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92879667
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92548456
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89784930
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85722008
28E2F1_18555785_Chip-Seq_ESCs_Mouse1.85254383
29EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.85085555
30SMAD4_21799915_ChIP-Seq_A2780_Human1.85072221
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.83748359
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.81035963
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81001014
34P53_22387025_ChIP-Seq_ESCs_Mouse1.77285972
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76707744
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76448365
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74904345
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74549375
39VDR_22108803_ChIP-Seq_LS180_Human1.72048045
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.71815817
41CMYC_18555785_Chip-Seq_ESCs_Mouse1.71765395
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.70877281
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70770579
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68409414
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.66085883
46ER_23166858_ChIP-Seq_MCF-7_Human1.65459422
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64796804
48STAT3_18555785_Chip-Seq_ESCs_Mouse1.64182603
49CBP_20019798_ChIP-Seq_JUKART_Human1.63570141
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63570141
51STAT3_23295773_ChIP-Seq_U87_Human1.62987972
52EWS_26573619_Chip-Seq_HEK293_Human1.62831097
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.60921996
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.60816966
55EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.60249533
56P300_18555785_Chip-Seq_ESCs_Mouse1.60038313
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.58708795
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.58544822
59NMYC_18555785_Chip-Seq_ESCs_Mouse1.58214350
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58061319
61REST_21632747_ChIP-Seq_MESCs_Mouse1.58050638
62RNF2_27304074_Chip-Seq_NSC_Mouse1.57543697
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.54057069
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51078842
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.50819968
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50215539
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48698152
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48698152
69TCF4_23295773_ChIP-Seq_U87_Human1.46471692
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45977498
71RUNX1_27457419_Chip-Seq_LIVER_Mouse1.45815670
72OCT4_18555785_Chip-Seq_ESCs_Mouse1.45378328
73GATA1_22025678_ChIP-Seq_K562_Human1.45097763
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44006771
75AR_25329375_ChIP-Seq_VCAP_Human1.42091367
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41940345
77PU1_27457419_Chip-Seq_LIVER_Mouse1.41245014
78AR_21572438_ChIP-Seq_LNCaP_Human1.41159865
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37517080
80KLF4_18555785_Chip-Seq_ESCs_Mouse1.37412325
81DROSHA_22980978_ChIP-Seq_HELA_Human1.36511761
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35147797
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.35088751
84ZFX_18555785_Chip-Seq_ESCs_Mouse1.33703656
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33682290
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33445623
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32826551
88CTCF_18555785_Chip-Seq_ESCs_Mouse1.32682512
89TP53_18474530_ChIP-ChIP_U2OS_Human1.31460157
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30397848
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28861345
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28861345
93SMAD1_18555785_Chip-Seq_ESCs_Mouse1.28626775
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28208526
95RUNX2_22187159_ChIP-Seq_PCA_Human1.28087303
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27511852
97ESRRB_18555785_Chip-Seq_ESCs_Mouse1.26500528
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26036670
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25452744
100BCAT_22108803_ChIP-Seq_LS180_Human1.25304518
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24164296
102MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24070708
103EZH2_27294783_Chip-Seq_ESCs_Mouse1.20166782
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19842570
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19838350
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18787547
107KDM2B_26808549_Chip-Seq_REH_Human1.16853214
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.16555048
109NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15982887
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15982887
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.15143433
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15069027
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14932440
114JUN_21703547_ChIP-Seq_K562_Human1.14564427
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.14409167
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.14305194
117ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13624069
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.13334517
119TCF4_22108803_ChIP-Seq_LS180_Human1.11302685
120SOX2_19829295_ChIP-Seq_ESCs_Human1.10308959
121NANOG_19829295_ChIP-Seq_ESCs_Human1.10308959
122TP53_22573176_ChIP-Seq_HFKS_Human1.10017690
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09132057
124TP53_16413492_ChIP-PET_HCT116_Human1.09126046
125FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07337364
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.05918684
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05514602
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.04145695
129IRF1_19129219_ChIP-ChIP_H3396_Human1.04118475
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01419884
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00315813
132EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98491709
133CDX2_22108803_ChIP-Seq_LS180_Human0.97757823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.41041233
2MP0004859_abnormal_synaptic_plasticity3.89819643
3MP0001188_hyperpigmentation3.82616221
4MP0004147_increased_porphyrin_level3.25672901
5MP0003787_abnormal_imprinting3.11269823
6MP0005171_absent_coat_pigmentation2.99896759
7MP0000569_abnormal_digit_pigmentation2.95035349
8MP0003136_yellow_coat_color2.83162604
9MP0002837_dystrophic_cardiac_calcinosis2.75916439
10MP0003635_abnormal_synaptic_transmissio2.73113266
11MP0001968_abnormal_touch/_nociception2.66035779
12MP0009745_abnormal_behavioral_response2.56356507
13MP0004270_analgesia2.55131804
14MP0005409_darkened_coat_color2.49498404
15MP0009046_muscle_twitch2.37093525
16MP0002736_abnormal_nociception_after2.37031846
17MP0002102_abnormal_ear_morphology2.30106751
18MP0002063_abnormal_learning/memory/cond2.26238785
19MP0001486_abnormal_startle_reflex2.24957318
20MP0005646_abnormal_pituitary_gland2.18653414
21MP0002735_abnormal_chemical_nociception2.17727124
22MP0002572_abnormal_emotion/affect_behav2.13108388
23MP0006292_abnormal_olfactory_placode2.11385688
24MP0002064_seizures2.11111796
25MP0000427_abnormal_hair_cycle2.05641353
26MP0002734_abnormal_mechanical_nocicepti2.00132956
27MP0000015_abnormal_ear_pigmentation1.96003276
28MP0006276_abnormal_autonomic_nervous1.95302848
29MP0008877_abnormal_DNA_methylation1.93599790
30MP0002272_abnormal_nervous_system1.90113347
31MP0002067_abnormal_sensory_capabilities1.85794623
32MP0000778_abnormal_nervous_system1.85329291
33MP0005645_abnormal_hypothalamus_physiol1.79942567
34MP0001440_abnormal_grooming_behavior1.76831827
35MP0010386_abnormal_urinary_bladder1.72328565
36MP0002876_abnormal_thyroid_physiology1.65200461
37MP0004742_abnormal_vestibular_system1.62144196
38MP0001501_abnormal_sleep_pattern1.61681346
39MP0005423_abnormal_somatic_nervous1.59861334
40MP0002184_abnormal_innervation1.57407584
41MP0004215_abnormal_myocardial_fiber1.50021570
42MP0002557_abnormal_social/conspecific_i1.49672090
43MP0004145_abnormal_muscle_electrophysio1.36447559
44MP0002733_abnormal_thermal_nociception1.34756919
45MP0004924_abnormal_behavior1.31032353
46MP0005386_behavior/neurological_phenoty1.31032353
47MP0001970_abnormal_pain_threshold1.28314959
48MP0000383_abnormal_hair_follicle1.26985653
49MP0002160_abnormal_reproductive_system1.26094286
50MP0001963_abnormal_hearing_physiology1.23815599
51MP0001905_abnormal_dopamine_level1.23756821
52MP0000371_diluted_coat_color1.23607249
53MP0003646_muscle_fatigue1.21651365
54MP0009697_abnormal_copulation1.20940547
55MP0001502_abnormal_circadian_rhythm1.20531429
56MP0001984_abnormal_olfaction1.18261409
57MP0000372_irregular_coat_pigmentation1.16278129
58MP0000955_abnormal_spinal_cord1.16076715
59MP0005551_abnormal_eye_electrophysiolog1.14441616
60MP0002882_abnormal_neuron_morphology1.12280596
61MP0003121_genomic_imprinting1.11493687
62MP0008569_lethality_at_weaning1.10830692
63MP0003195_calcinosis1.10197139
64MP0000647_abnormal_sebaceous_gland1.09804595
65MP0008260_abnormal_autophagy1.06710532
66MP0002909_abnormal_adrenal_gland1.04809641
67MP0004130_abnormal_muscle_cell1.04315571
68MP0008058_abnormal_DNA_repair1.03142119
69MP0001177_atelectasis1.02976919
70MP0010678_abnormal_skin_adnexa1.02147235
71MP0000631_abnormal_neuroendocrine_gland1.02023734
72MP0002638_abnormal_pupillary_reflex1.00288574
73MP0000026_abnormal_inner_ear1.00044510
74MP0001529_abnormal_vocalization0.99467220
75MP0004142_abnormal_muscle_tone0.97557344
76MP0002066_abnormal_motor_capabilities/c0.97417997
77MP0004811_abnormal_neuron_physiology0.96751803
78MP0004134_abnormal_chest_morphology0.96704716
79MP0006072_abnormal_retinal_apoptosis0.94770972
80MP0001485_abnormal_pinna_reflex0.94551829
81MP0005167_abnormal_blood-brain_barrier0.93019304
82MP0004084_abnormal_cardiac_muscle0.90975313
83MP0002234_abnormal_pharynx_morphology0.90728219
84MP0002752_abnormal_somatic_nervous0.90250259
85MP0004043_abnormal_pH_regulation0.87201314
86MP0004484_altered_response_of0.87093970
87MP0005253_abnormal_eye_physiology0.86477401
88MP0000566_synostosis0.86427975
89MP0003879_abnormal_hair_cell0.85101927
90MP0003938_abnormal_ear_development0.84877930
91MP0003632_abnormal_nervous_system0.84395223
92MP0005187_abnormal_penis_morphology0.84097801
93MP0002095_abnormal_skin_pigmentation0.83713533
94MP0008057_abnormal_DNA_replication0.83629420
95MP0003718_maternal_effect0.83214908
96MP0002822_catalepsy0.83212362
97MP0003656_abnormal_erythrocyte_physiolo0.82979737
98MP0001986_abnormal_taste_sensitivity0.81829505
99MP0003631_nervous_system_phenotype0.81071116
100MP0008872_abnormal_physiological_respon0.80383318
101MP0005075_abnormal_melanosome_morpholog0.80367936
102MP0002177_abnormal_outer_ear0.80347058
103MP0001324_abnormal_eye_pigmentation0.79541827
104MP0000013_abnormal_adipose_tissue0.78926032
105MP0005174_abnormal_tail_pigmentation0.78905304
106MP0003283_abnormal_digestive_organ0.78049244
107MP0002152_abnormal_brain_morphology0.77759189
108MP0001186_pigmentation_phenotype0.77166142
109MP0001346_abnormal_lacrimal_gland0.76739237
110MP0009780_abnormal_chondrocyte_physiolo0.74780751
111MP0000681_abnormal_thyroid_gland0.74049297
112MP0002229_neurodegeneration0.73060614
113MP0005379_endocrine/exocrine_gland_phen0.72475376
114MP0005389_reproductive_system_phenotype0.72377375
115MP0008004_abnormal_stomach_pH0.72175149
116MP0008875_abnormal_xenobiotic_pharmacok0.71977271
117MP0002163_abnormal_gland_morphology0.71943941
118MP0005195_abnormal_posterior_eye0.70937753
119MP0003633_abnormal_nervous_system0.70805196
120MP0002009_preneoplasia0.70186778
121MP0002277_abnormal_respiratory_mucosa0.69639232
122MP0003937_abnormal_limbs/digits/tail_de0.68710786
123MP0003183_abnormal_peptide_metabolism0.67722632
124MP0002075_abnormal_coat/hair_pigmentati0.63847069
125MP0004885_abnormal_endolymph0.63698932
126MP0000920_abnormal_myelination0.63477390
127MP0003698_abnormal_male_reproductive0.62621046

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.56065759
2Febrile seizures (HP:0002373)5.29123766
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.87419703
4Epileptic encephalopathy (HP:0200134)3.62487616
5Chromsome breakage (HP:0040012)3.50049122
6Focal seizures (HP:0007359)3.40298967
7Atonic seizures (HP:0010819)3.26371714
8Hyperventilation (HP:0002883)3.22653430
9Pancreatic cysts (HP:0001737)3.22466458
10Genetic anticipation (HP:0003743)2.99009851
11Gaze-evoked nystagmus (HP:0000640)2.90859970
12Type II lissencephaly (HP:0007260)2.89279732
13Renal cortical cysts (HP:0000803)2.86264964
14Protruding tongue (HP:0010808)2.84063917
15Hypothermia (HP:0002045)2.83642719
16Absent speech (HP:0001344)2.78581619
17Broad-based gait (HP:0002136)2.77801866
18Methylmalonic acidemia (HP:0002912)2.77648941
19Papillary thyroid carcinoma (HP:0002895)2.76154073
20Lissencephaly (HP:0001339)2.74692071
21Abnormality of the renal cortex (HP:0011035)2.68360295
22Abnormal ciliary motility (HP:0012262)2.67454445
23Progressive cerebellar ataxia (HP:0002073)2.56827525
24Abnormality of the renal medulla (HP:0100957)2.56315590
25Generalized tonic-clonic seizures (HP:0002069)2.52099771
26Progressive inability to walk (HP:0002505)2.51963851
27Excessive salivation (HP:0003781)2.49304112
28Drooling (HP:0002307)2.49304112
29Generalized hypopigmentation of hair (HP:0011358)2.46079893
30Degeneration of the lateral corticospinal tracts (HP:0002314)2.45994624
31Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45994624
32Blue irides (HP:0000635)2.45979973
33Absent/shortened dynein arms (HP:0200106)2.44617226
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.44617226
35Medial flaring of the eyebrow (HP:0010747)2.41788134
36Dialeptic seizures (HP:0011146)2.41742323
37Chronic hepatic failure (HP:0100626)2.40561058
38Fair hair (HP:0002286)2.39890135
39Prostate neoplasm (HP:0100787)2.37978256
40Abnormality of the renal collecting system (HP:0004742)2.37567659
41Cerebellar dysplasia (HP:0007033)2.36135899
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.33459408
43Hypoplasia of the fovea (HP:0007750)2.33459408
44Decreased central vision (HP:0007663)2.28297012
45Abnormality of alanine metabolism (HP:0010916)2.27869938
46Hyperalaninemia (HP:0003348)2.27869938
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27869938
48Chorioretinal atrophy (HP:0000533)2.26765701
49Congenital sensorineural hearing impairment (HP:0008527)2.22270111
50Absence seizures (HP:0002121)2.21678270
51Gait imbalance (HP:0002141)2.20638298
52Thyroid carcinoma (HP:0002890)2.20312253
53Abnormal respiratory motile cilium physiology (HP:0012261)2.19949089
54EEG with generalized epileptiform discharges (HP:0011198)2.19797788
55Hypsarrhythmia (HP:0002521)2.19439611
56Pachygyria (HP:0001302)2.16105486
57White forelock (HP:0002211)2.14090226
58Abnormality of the corticospinal tract (HP:0002492)2.12612045
59Attenuation of retinal blood vessels (HP:0007843)2.12475731
60Nephrogenic diabetes insipidus (HP:0009806)2.11085119
61Hip dysplasia (HP:0001385)2.09693194
62Fetal akinesia sequence (HP:0001989)2.09641443
63Urinary bladder sphincter dysfunction (HP:0002839)2.09060956
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08607138
65Septo-optic dysplasia (HP:0100842)2.08099973
66Upper limb muscle weakness (HP:0003484)2.06673431
67Hemiparesis (HP:0001269)2.06542167
68Optic nerve hypoplasia (HP:0000609)2.06477682
69Oligodactyly (hands) (HP:0001180)2.06432394
70Abnormality of salivation (HP:0100755)2.05110043
71Gastroesophageal reflux (HP:0002020)2.04606311
72Congenital primary aphakia (HP:0007707)2.01729374
73Tubulointerstitial nephritis (HP:0001970)2.00889582
74Amyotrophic lateral sclerosis (HP:0007354)1.98866894
75Neoplasm of the oral cavity (HP:0100649)1.98784582
76Widely spaced teeth (HP:0000687)1.98358960
77Absent frontal sinuses (HP:0002688)1.98239732
78Median cleft lip (HP:0000161)1.97994951
79Short tibia (HP:0005736)1.97961255
80True hermaphroditism (HP:0010459)1.97791834
81Patchy hypopigmentation of hair (HP:0011365)1.96838633
82Inappropriate behavior (HP:0000719)1.96751668
83Myokymia (HP:0002411)1.96379147
84Morphological abnormality of the pyramidal tract (HP:0002062)1.95977036
85Congenital hepatic fibrosis (HP:0002612)1.95490560
86Agitation (HP:0000713)1.94978513
87Pancreatic fibrosis (HP:0100732)1.94931448
88Specific learning disability (HP:0001328)1.94877688
89Duplicated collecting system (HP:0000081)1.93957883
90Birth length less than 3rd percentile (HP:0003561)1.93891165
91Abnormal respiratory motile cilium morphology (HP:0005938)1.93282436
92Abnormal respiratory epithelium morphology (HP:0012253)1.93282436
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.91213922
94Urinary urgency (HP:0000012)1.89132564
95Exotropia (HP:0000577)1.88784915
963-Methylglutaconic aciduria (HP:0003535)1.88031558
97Albinism (HP:0001022)1.87881883
98Abnormality of the fovea (HP:0000493)1.86375761
99Abnormal hair whorl (HP:0010721)1.86106009
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.85703351
101Medulloblastoma (HP:0002885)1.85045399
102Impaired vibration sensation in the lower limbs (HP:0002166)1.81859020
103Biliary tract neoplasm (HP:0100574)1.81294956
104Neoplasm of the heart (HP:0100544)1.81254329
105Retinal dysplasia (HP:0007973)1.81229514
106Lower limb muscle weakness (HP:0007340)1.79041860
107Inability to walk (HP:0002540)1.76419208
108Preaxial hand polydactyly (HP:0001177)1.75289043
109Dysdiadochokinesis (HP:0002075)1.74928189
110Abnormality of the frontal sinuses (HP:0002687)1.74378843
111Poor eye contact (HP:0000817)1.73393868
112Volvulus (HP:0002580)1.72862803
113Epileptiform EEG discharges (HP:0011182)1.71985786
114Postaxial foot polydactyly (HP:0001830)1.71379026
115Nephronophthisis (HP:0000090)1.71330320
116Abnormality of vitamin B metabolism (HP:0004340)1.71158184
117Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71056619
118Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70259196
119Short 4th metacarpal (HP:0010044)1.70259196
120Astigmatism (HP:0000483)1.70065140
121Cystic liver disease (HP:0006706)1.69567023
122Spastic tetraplegia (HP:0002510)1.68511534
123Dyskinesia (HP:0100660)1.65990185
124Long nose (HP:0003189)1.65651001
125Poor coordination (HP:0002370)1.65622568
126Genital tract atresia (HP:0001827)1.64321511
127Methylmalonic aciduria (HP:0012120)1.64162334
128Spastic gait (HP:0002064)1.64025060
129Limb dystonia (HP:0002451)1.63755694
130Small hand (HP:0200055)1.63314620
131Congenital stationary night blindness (HP:0007642)1.63158615
132Large for gestational age (HP:0001520)1.62920625
133Abnormality of the preputium (HP:0100587)1.62422774
134Osteomalacia (HP:0002749)1.62120751
135Atelectasis (HP:0100750)1.61992146
136Abnormality of chromosome stability (HP:0003220)1.61990260
137Bradycardia (HP:0001662)1.61937521
138Absent septum pellucidum (HP:0001331)1.61334576
139Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.61062887
140Abnormality of incisor morphology (HP:0011063)1.60713331
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60543142
142Akinesia (HP:0002304)1.60297680
143Lip pit (HP:0100267)1.59713517
144Aplasia/Hypoplasia of the lens (HP:0008063)1.59349198
145Aplasia/Hypoplasia of the tibia (HP:0005772)1.59191228
146Vaginal atresia (HP:0000148)1.58777078
147Action tremor (HP:0002345)1.58662247
148Amblyopia (HP:0000646)1.57310325
149Abnormality of the labia minora (HP:0012880)1.56235594
150Molar tooth sign on MRI (HP:0002419)1.55968804
151Abnormality of midbrain morphology (HP:0002418)1.55968804
152Truncal ataxia (HP:0002078)1.55062105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.38157688
2NTRK33.25723826
3TNIK2.98094063
4EPHA42.85408731
5PLK22.65363647
6MAP2K72.61821969
7RIPK42.56246498
8ACVR1B2.48975336
9BMPR22.33820079
10MAP3K42.26637539
11PINK12.10485609
12TRIM282.02943658
13MAP4K22.00512852
14TIE11.84466594
15ERBB31.80326925
16INSRR1.78654534
17MARK11.71592352
18TAOK31.58848786
19MAPK131.58629191
20AKT31.55560657
21PLK41.52133824
22OXSR11.52064056
23MAP3K121.51352379
24BCR1.50126360
25PRPF4B1.43352548
26PAK31.38370934
27PHKG21.36879415
28PHKG11.36879415
29EIF2AK21.35979939
30ADRBK21.35749091
31YES11.30114559
32PDK21.29776934
33DAPK21.28348548
34PNCK1.26345266
35MINK11.24048273
36CSNK1G11.21561832
37ZAK1.19037768
38CAMKK11.18832277
39CDK31.17767901
40NEK61.17734375
41MKNK21.16800545
42STK161.08903010
43STK38L1.07241950
44CSNK1G31.06567686
45SGK21.05288347
46MUSK1.03356974
47OBSCN1.02720770
48FRK1.02263508
49MAP3K141.01801738
50CAMK2A1.01267943
51PRKCE0.99574653
52MET0.97219951
53PTK2B0.94247155
54CDK190.93886891
55NEK90.89314417
56NTRK20.88640622
57CAMK2B0.88573669
58TNK20.88447489
59MKNK10.87358512
60SGK10.86594639
61BRD40.85903908
62FER0.85582074
63CDK50.81998169
64IRAK40.81737314
65PRKCG0.81576414
66MAPKAPK50.81227133
67CLK10.80371626
68GRK70.78567384
69SGK2230.78321637
70SGK4940.78321637
71DAPK10.77131859
72BCKDK0.76543350
73PIK3CA0.73132381
74FGR0.72559484
75NUAK10.70365257
76IRAK30.70283876
77EPHA30.69241126
78SRPK10.68906680
79CAMKK20.68691107
80CAMK40.68569684
81GRK50.68395480
82TGFBR10.67178816
83MAP2K40.63826072
84KSR10.63718294
85IRAK20.62371188
86PLK30.62012581
87BMPR1B0.61959095
88STK390.61475866
89MAP3K130.60104129
90PKN10.59149294
91TRPM70.59082515
92RPS6KA50.58994469
93TXK0.58723218
94CAMK1G0.57897321
95SIK20.57779915
96EIF2AK30.56238302
97PRKAA10.52869432
98DYRK30.52493845
99CAMK2D0.52195689
100PIK3CG0.51879793
101STK110.51811648
102CCNB10.51458979
103DYRK1A0.50959256
104TEC0.50677031
105CSNK1G20.50483075
106MAPK120.49727631
107TLK10.47746718
108MAP3K90.47732805
109BLK0.47527234
110VRK10.46709061
111FES0.46168544
112MAP2K10.45517257
113WNK40.45375245
114UHMK10.45004846
115NTRK10.44878848
116PAK60.44276928
117PRKCI0.44179569
118PRKACB0.43182815
119PBK0.42193518
120PRKG10.41414040
121WNK30.39027141
122MAPK100.39004093
123CSNK1A1L0.38948526
124TTK0.38834724
125STK380.37935662
126PRKACA0.37930658
127SIK30.37836068
128MAP3K60.37606632
129ADRBK10.37306134
130EGFR0.37039747
131STK30.36883834
132GRK10.36388194
133CAMK10.35571439
134CAMK1D0.35540746
135SGK30.34638459
136ATM0.34257185
137CSNK1D0.34004973
138BRSK20.33700936
139IRAK10.33560808
140RPS6KB10.32982795

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.75236611
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66621005
3Butanoate metabolism_Homo sapiens_hsa006502.45914519
4Selenocompound metabolism_Homo sapiens_hsa004502.44837835
5Morphine addiction_Homo sapiens_hsa050322.34706767
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32550423
7Synaptic vesicle cycle_Homo sapiens_hsa047212.24145703
8Glutamatergic synapse_Homo sapiens_hsa047242.17271306
9Olfactory transduction_Homo sapiens_hsa047402.04060581
10Circadian entrainment_Homo sapiens_hsa047132.02346714
11Serotonergic synapse_Homo sapiens_hsa047261.96919789
12Amphetamine addiction_Homo sapiens_hsa050311.89011049
13Taste transduction_Homo sapiens_hsa047421.88492725
14Collecting duct acid secretion_Homo sapiens_hsa049661.88189099
15GABAergic synapse_Homo sapiens_hsa047271.84339378
16Propanoate metabolism_Homo sapiens_hsa006401.82718637
17Long-term potentiation_Homo sapiens_hsa047201.77587481
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75805915
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73103677
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70451612
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63600449
22Tryptophan metabolism_Homo sapiens_hsa003801.58902660
23Salivary secretion_Homo sapiens_hsa049701.56885933
24Phototransduction_Homo sapiens_hsa047441.56732806
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.53850564
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.52828725
27Insulin secretion_Homo sapiens_hsa049111.51474866
28Dopaminergic synapse_Homo sapiens_hsa047281.50715937
29Calcium signaling pathway_Homo sapiens_hsa040201.47220829
30Nitrogen metabolism_Homo sapiens_hsa009101.43972786
31ABC transporters_Homo sapiens_hsa020101.42473736
32Long-term depression_Homo sapiens_hsa047301.42346918
33Cholinergic synapse_Homo sapiens_hsa047251.41361295
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36167693
35Renin secretion_Homo sapiens_hsa049241.33083281
36Steroid biosynthesis_Homo sapiens_hsa001001.28654690
37Fanconi anemia pathway_Homo sapiens_hsa034601.27021850
38Systemic lupus erythematosus_Homo sapiens_hsa053221.26394316
39Inositol phosphate metabolism_Homo sapiens_hsa005621.19232640
40Cocaine addiction_Homo sapiens_hsa050301.18876023
41Axon guidance_Homo sapiens_hsa043601.18427262
42Ether lipid metabolism_Homo sapiens_hsa005651.18355759
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17525852
44Type I diabetes mellitus_Homo sapiens_hsa049401.12506822
45Rheumatoid arthritis_Homo sapiens_hsa053231.12380240
46Dorso-ventral axis formation_Homo sapiens_hsa043201.12261986
47Vibrio cholerae infection_Homo sapiens_hsa051101.09316422
48Oxytocin signaling pathway_Homo sapiens_hsa049211.08081229
49cAMP signaling pathway_Homo sapiens_hsa040241.06765002
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03406011
51Sphingolipid metabolism_Homo sapiens_hsa006001.03298254
52Protein export_Homo sapiens_hsa030601.02977652
53Caffeine metabolism_Homo sapiens_hsa002321.00256211
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98051967
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98000136
56GnRH signaling pathway_Homo sapiens_hsa049120.97555725
57Gastric acid secretion_Homo sapiens_hsa049710.97321355
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.96434107
59Peroxisome_Homo sapiens_hsa041460.96356898
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95930405
61ErbB signaling pathway_Homo sapiens_hsa040120.95677134
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94941904
63Phagosome_Homo sapiens_hsa041450.94722541
64Sulfur metabolism_Homo sapiens_hsa009200.90659907
65Non-homologous end-joining_Homo sapiens_hsa034500.86756613
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86508006
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85880138
68Ras signaling pathway_Homo sapiens_hsa040140.82957691
69Alcoholism_Homo sapiens_hsa050340.79467102
70beta-Alanine metabolism_Homo sapiens_hsa004100.79266687
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78724518
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77100590
73Choline metabolism in cancer_Homo sapiens_hsa052310.75667822
74Gap junction_Homo sapiens_hsa045400.73579443
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73412240
76Melanogenesis_Homo sapiens_hsa049160.73263593
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.72936590
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71242037
79Glioma_Homo sapiens_hsa052140.71022512
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70997076
81African trypanosomiasis_Homo sapiens_hsa051430.70081661
82MAPK signaling pathway_Homo sapiens_hsa040100.70047336
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69900069
84Fatty acid biosynthesis_Homo sapiens_hsa000610.69534617
85Autoimmune thyroid disease_Homo sapiens_hsa053200.69423168
86Type II diabetes mellitus_Homo sapiens_hsa049300.69086152
87Melanoma_Homo sapiens_hsa052180.66738247
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66431955
89Wnt signaling pathway_Homo sapiens_hsa043100.66115855
90Ovarian steroidogenesis_Homo sapiens_hsa049130.65625581
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65422316
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64844511
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64008459
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64006525
95Circadian rhythm_Homo sapiens_hsa047100.63740110
96Estrogen signaling pathway_Homo sapiens_hsa049150.63200085
97Graft-versus-host disease_Homo sapiens_hsa053320.61916520
98Allograft rejection_Homo sapiens_hsa053300.60270467
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58555425
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.54945057
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54252966
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53557073
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.52926100
104RNA degradation_Homo sapiens_hsa030180.52055841
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51503229
106Chemokine signaling pathway_Homo sapiens_hsa040620.50913152
107Basal transcription factors_Homo sapiens_hsa030220.50709001
108Glycerolipid metabolism_Homo sapiens_hsa005610.48455351
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.48302803
110Pancreatic secretion_Homo sapiens_hsa049720.46240621
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45976798
112TNF signaling pathway_Homo sapiens_hsa046680.45457780
113Homologous recombination_Homo sapiens_hsa034400.45079661
114Rap1 signaling pathway_Homo sapiens_hsa040150.44414992
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44346451
116Oocyte meiosis_Homo sapiens_hsa041140.44207310
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.43673959
118Fatty acid metabolism_Homo sapiens_hsa012120.43558159
119Linoleic acid metabolism_Homo sapiens_hsa005910.40602980
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40008151
121Chemical carcinogenesis_Homo sapiens_hsa052040.39751425
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39371990
123Mineral absorption_Homo sapiens_hsa049780.38251552
124Arachidonic acid metabolism_Homo sapiens_hsa005900.37940055
125Histidine metabolism_Homo sapiens_hsa003400.37493523
126Tuberculosis_Homo sapiens_hsa051520.37485828
127Regulation of autophagy_Homo sapiens_hsa041400.36643754
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36356782
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34797852
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34376392
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34213456
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33800904
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33715894
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33363490
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33208565
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32761192
137Fatty acid degradation_Homo sapiens_hsa000710.30373368
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29366928
139Purine metabolism_Homo sapiens_hsa002300.28600331

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