VPS51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in retrograde transport from the early and late endosomes to the trans-Golgi network. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.55433949
2COPI coating of Golgi vesicle (GO:0048205)6.55433949
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.31258064
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.31258064
5antigen processing and presentation via MHC class Ib (GO:0002475)5.89141131
6antigen processing and presentation of endogenous antigen (GO:0019883)5.53858835
7negative regulation of erythrocyte differentiation (GO:0045647)4.40450227
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.34212731
9DNA deamination (GO:0045006)4.02962804
10negative regulation of cell size (GO:0045792)4.01086254
11thymic T cell selection (GO:0045061)3.99508549
12positive regulation of gamma-delta T cell activation (GO:0046645)3.72623042
13sodium ion export (GO:0071436)3.60259001
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.57530578
15ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.52162834
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.50440276
17regulation of gamma-delta T cell differentiation (GO:0045586)3.49067135
18positive regulation of nuclease activity (GO:0032075)3.47181754
19pentose-phosphate shunt (GO:0006098)3.41247910
20regulation of early endosome to late endosome transport (GO:2000641)3.32825283
21protein maturation by protein folding (GO:0022417)3.28364366
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.27695319
23negative regulation of cell killing (GO:0031342)3.27695319
24apoptotic process involved in morphogenesis (GO:0060561)3.26645085
25detection of bacterium (GO:0016045)3.25361557
26negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.24979286
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.24330228
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22080801
29synaptic vesicle maturation (GO:0016188)3.19510688
30T cell selection (GO:0045058)3.19296637
31L-alpha-amino acid transmembrane transport (GO:1902475)3.17393733
32protein retention in ER lumen (GO:0006621)3.16928881
33regulation of gamma-delta T cell activation (GO:0046643)3.15580699
34regulation of translational termination (GO:0006449)3.14185059
35regulation of protein heterodimerization activity (GO:0043497)3.12468113
363-UTR-mediated mRNA stabilization (GO:0070935)3.12041823
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10190337
38regulation of nuclease activity (GO:0032069)3.09998244
39modulation by virus of host process (GO:0019054)3.09820504
40positive T cell selection (GO:0043368)3.05892608
41tricarboxylic acid metabolic process (GO:0072350)3.05037368
42positive regulation by symbiont of host defense response (GO:0052509)3.04932599
43modulation by symbiont of host defense response (GO:0052031)3.04932599
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.04932599
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.04932599
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.04932599
47modulation by symbiont of host immune response (GO:0052553)3.04932599
48peptidyl-tyrosine autophosphorylation (GO:0038083)3.02470113
49detection of other organism (GO:0098543)3.02124468
50natural killer cell differentiation (GO:0001779)2.98505500
51folic acid-containing compound biosynthetic process (GO:0009396)2.93950525
52modulation by symbiont of host cellular process (GO:0044068)2.93205191
53NADPH regeneration (GO:0006740)2.92538194
54B cell receptor signaling pathway (GO:0050853)2.91981434
55negative thymic T cell selection (GO:0045060)2.87702809
56regulation of interleukin-12 biosynthetic process (GO:0045075)2.85692023
57regulation of defense response to virus by virus (GO:0050690)2.83532207
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80976110
59regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.79980894
60response to laminar fluid shear stress (GO:0034616)2.79051136
61positive regulation of histone deacetylation (GO:0031065)2.78166947
62regulation of extracellular matrix disassembly (GO:0010715)2.76897173
63regulation of translational fidelity (GO:0006450)2.75978052
64endoplasmic reticulum unfolded protein response (GO:0030968)2.75932324
65positive regulation of Cdc42 GTPase activity (GO:0043089)2.75466754
66vesicle coating (GO:0006901)2.72829791
67negative regulation of microtubule polymerization (GO:0031115)2.72422112
68response to muramyl dipeptide (GO:0032495)2.71475246
69negative regulation of glycoprotein biosynthetic process (GO:0010561)2.71306446
70barbed-end actin filament capping (GO:0051016)2.69700231
71regulation of glucose import in response to insulin stimulus (GO:2001273)2.69337340
72signal complex assembly (GO:0007172)2.68494986
73positive regulation of Rap GTPase activity (GO:0032854)2.67891265
74regulation of ARF GTPase activity (GO:0032312)2.66633891
75negative regulation of myotube differentiation (GO:0010832)2.66400982
76regulation of type I interferon-mediated signaling pathway (GO:0060338)2.65768490
77beta-amyloid metabolic process (GO:0050435)2.65350201
78negative regulation of phagocytosis (GO:0050765)2.65341408
79activation of JUN kinase activity (GO:0007257)2.65012744
80cellular response to topologically incorrect protein (GO:0035967)2.64804955
81regulation of erythrocyte differentiation (GO:0045646)2.63875761
82ribosomal small subunit assembly (GO:0000028)2.63415341
83negative T cell selection (GO:0043383)2.63408755
84positive regulation of protein deacetylation (GO:0090312)2.62482428
85cellular response to unfolded protein (GO:0034620)2.62378516
86JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62169247
87mucosal-associated lymphoid tissue development (GO:0048537)2.61540604
88Peyers patch development (GO:0048541)2.61540604
89negative regulation of viral release from host cell (GO:1902187)2.61367563
90purine-containing compound salvage (GO:0043101)2.61075927
91galactose catabolic process (GO:0019388)2.59579539
92intracellular estrogen receptor signaling pathway (GO:0030520)2.59247206
93actin nucleation (GO:0045010)2.58625855
94serine transport (GO:0032329)2.58161169
95negative regulation of innate immune response (GO:0045824)2.57951836
96embryonic process involved in female pregnancy (GO:0060136)2.57660239
97regulation of chromatin binding (GO:0035561)2.57228276
98activation of MAPKKK activity (GO:0000185)2.56343430
99positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.55590808
100ER-nucleus signaling pathway (GO:0006984)2.54799436
101regulation of cholesterol homeostasis (GO:2000188)2.54723760
102regulation of autophagic vacuole assembly (GO:2000785)2.54613653
103response to pheromone (GO:0019236)2.53441061
104regulation of necrotic cell death (GO:0010939)2.53231629
105glucocorticoid receptor signaling pathway (GO:0042921)2.52402203
106epithelial cell differentiation involved in prostate gland development (GO:0060742)2.52074662
107negative regulation of necroptotic process (GO:0060546)2.52074560
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52008323
109negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50840154
110NADH metabolic process (GO:0006734)2.50260434
111cerebellar Purkinje cell layer development (GO:0021680)2.50153980
112activation of Rac GTPase activity (GO:0032863)2.50111716
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.49888788
114virion assembly (GO:0019068)2.48802064
115negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.48410670
116peptidyl-lysine dimethylation (GO:0018027)2.48064178
117adaptation of signaling pathway (GO:0023058)2.47838151
118histone H3-K36 demethylation (GO:0070544)2.46907951
119execution phase of apoptosis (GO:0097194)2.46503821
120ribosomal small subunit biogenesis (GO:0042274)2.46138225
121negative regulation of toll-like receptor signaling pathway (GO:0034122)2.45939260
122focal adhesion assembly (GO:0048041)2.45646555
123cell-substrate adherens junction assembly (GO:0007045)2.45646555
124positive regulation of triglyceride biosynthetic process (GO:0010867)2.45475976
125regulation of leukocyte degranulation (GO:0043300)2.44336934
126regulation of B cell receptor signaling pathway (GO:0050855)2.43809838
127regulation of synapse structural plasticity (GO:0051823)2.43521657
128positive regulation of synapse maturation (GO:0090129)2.42335915
129maternal placenta development (GO:0001893)2.42297273
130positive thymic T cell selection (GO:0045059)2.41935053
131adherens junction assembly (GO:0034333)2.41593518
132positive regulation of B cell differentiation (GO:0045579)2.41008630
133response to interleukin-4 (GO:0070670)2.40705239
134mannose metabolic process (GO:0006013)2.40264533
135cellular response to interleukin-4 (GO:0071353)2.40051733
136leukocyte aggregation (GO:0070486)2.39810826
137cell communication by electrical coupling (GO:0010644)2.38757588
138response to peptidoglycan (GO:0032494)2.38657814
139negative regulation of TOR signaling (GO:0032007)2.38483069
140immunoglobulin mediated immune response (GO:0016064)2.38447745
141N-glycan processing (GO:0006491)2.37917140
142regulation of NFAT protein import into nucleus (GO:0051532)2.37911693
143negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.37884948
144negative regulation of glial cell proliferation (GO:0060253)2.36772457
145regulation of necroptotic process (GO:0060544)2.35563436
146cellular response to virus (GO:0098586)2.35242107
147regulation of B cell differentiation (GO:0045577)2.34873864
148regulation of myeloid leukocyte mediated immunity (GO:0002886)2.34859318
149peptidyl-arginine omega-N-methylation (GO:0035247)2.33941534
150cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.33580516
151NIK/NF-kappaB signaling (GO:0038061)2.33294429
152GDP-mannose metabolic process (GO:0019673)2.32330293
153glucose catabolic process (GO:0006007)2.32220362
154positive regulation of insulin secretion (GO:0032024)2.32078399
155negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.32014813
156positive regulation of lamellipodium assembly (GO:0010592)2.31572425
157positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.30246842
158viral transcription (GO:0019083)2.29072650
159pyrimidine nucleoside salvage (GO:0043097)2.28868511
160pyrimidine-containing compound salvage (GO:0008655)2.28868511
161regulation of ARF protein signal transduction (GO:0032012)2.28790966
162regulation of dendritic cell antigen processing and presentation (GO:0002604)2.28728633
163negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.27152639
164protein localization to endosome (GO:0036010)2.25814463
165actin filament polymerization (GO:0030041)2.25338018
166regulation of mammary gland epithelial cell proliferation (GO:0033599)2.23738542
167positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.22650398
168negative regulation of fatty acid transport (GO:2000192)2.22499654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.52537278
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18922408
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.01189750
4VDR_21846776_ChIP-Seq_THP-1_Human2.73554145
5LXR_22292898_ChIP-Seq_THP-1_Human2.33765731
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14303935
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.11838657
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11152140
9TCF7_22412390_ChIP-Seq_EML_Mouse2.09893547
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02950297
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97605953
12CIITA_25753668_ChIP-Seq_RAJI_Human1.94104688
13KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93986757
14TP63_17297297_ChIP-ChIP_HaCaT_Human1.93565199
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92989091
16BP1_19119308_ChIP-ChIP_Hs578T_Human1.92093771
17KDM2B_26808549_Chip-Seq_DND41_Human1.91686500
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89235795
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88377996
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85974914
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83972029
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.83319575
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82971443
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78583734
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70133827
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69001302
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67991919
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.66777945
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.65021595
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64123314
31UTX_26944678_Chip-Seq_JUKART_Human1.63566369
32MAF_26560356_Chip-Seq_TH1_Human1.62481654
33GATA1_22025678_ChIP-Seq_K562_Human1.62466818
34P68_20966046_ChIP-Seq_HELA_Human1.62006911
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59021633
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57747778
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57584917
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57503019
39XRN2_22483619_ChIP-Seq_HELA_Human1.56757371
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56638827
41E2F7_22180533_ChIP-Seq_HELA_Human1.56540176
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53794876
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53658533
44VDR_24763502_ChIP-Seq_THP-1_Human1.52414223
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49915767
46BCL6_27268052_Chip-Seq_Bcells_Human1.47883213
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46970885
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41506114
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40380145
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.40278110
51BCOR_27268052_Chip-Seq_Bcells_Human1.40200295
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38050148
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.37935475
54SPI1_23127762_ChIP-Seq_K562_Human1.36521438
55SCL_19346495_ChIP-Seq_HPC-7_Human1.35185950
56PHF8_20622854_ChIP-Seq_HELA_Human1.34961565
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33857012
58RACK7_27058665_Chip-Seq_MCF-7_Human1.33701835
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31776299
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31017474
61* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30964985
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.30291859
63YY1_22570637_ChIP-Seq_MALME-3M_Human1.29881411
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29528032
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.27918360
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27333107
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27114594
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26865502
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26713752
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26175710
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25948288
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25764310
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25643200
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24163147
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23669889
76SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.23288192
77MAF_26560356_Chip-Seq_TH2_Human1.23127734
78CTCF_27219007_Chip-Seq_Bcells_Human1.21350403
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.19491170
80KDM2B_26808549_Chip-Seq_K562_Human1.18594087
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.17491646
82SMC4_20622854_ChIP-Seq_HELA_Human1.17471747
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16844671
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16648165
85ZNF263_19887448_ChIP-Seq_K562_Human1.16384201
86MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16327383
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15944006
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14716146
89MYB_26560356_Chip-Seq_TH2_Human1.14597445
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.14516195
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14117622
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14054293
93GABP_19822575_ChIP-Seq_HepG2_Human1.13989375
94TFEB_21752829_ChIP-Seq_HELA_Human1.13484915
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13249639
96ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12984747
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12857430
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11404919
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11387617
100ATF3_27146783_Chip-Seq_COLON_Human1.11104980
101STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10737001
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10270520
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10187086
104MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10123590
105NCOR1_26117541_ChIP-Seq_K562_Human1.09631410
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.08632520
107PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08586816
108CTCF_21964334_Chip-Seq_Bcells_Human1.07648372
109CREB1_26743006_Chip-Seq_LNCaP_Human1.07106903
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.07065866
111ETS1_21867929_ChIP-Seq_TH2_Mouse1.06850041
112STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06584343
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06457031
114CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06029248
115EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05037976
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04600099
117FOXP1_21924763_ChIP-Seq_HESCs_Human1.04125698
118RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03856855
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.03538064
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03300805
121SA1_27219007_Chip-Seq_Bcells_Human1.02392776
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02348696
123MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02292319
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02211604
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01915958
126BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01865873
127P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01793732
128SPI1_23547873_ChIP-Seq_NB4_Human1.01291535
129TP63_22573176_ChIP-Seq_HFKS_Human1.00163932
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99749299
131E2F1_20622854_ChIP-Seq_HELA_Human0.99141647
132RARB_24833708_ChIP-Seq_LIVER_Mouse0.99112047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.42866737
2MP0003172_abnormal_lysosome_physiology3.01273124
3MP0002653_abnormal_ependyma_morphology3.00304567
4MP0009840_abnormal_foam_cell2.87558210
5MP0000685_abnormal_immune_system2.82521566
6MP0002909_abnormal_adrenal_gland2.69324366
7MP0003183_abnormal_peptide_metabolism2.66964500
8MP0008961_abnormal_basal_metabolism2.64516159
9MP0003329_amyloid_beta_deposits2.41147227
10MP0004859_abnormal_synaptic_plasticity2.31767792
11MP0001835_abnormal_antigen_presentation2.25271712
12MP0008260_abnormal_autophagy2.21399166
13MP0004858_abnormal_nervous_system2.20370947
14MP0003303_peritoneal_inflammation2.14084000
15MP0010234_abnormal_vibrissa_follicle2.13488378
16MP0003436_decreased_susceptibility_to2.02296735
17MP0000604_amyloidosis1.99969884
18MP0003300_gastrointestinal_ulcer1.95819191
19MP0002396_abnormal_hematopoietic_system1.87733219
20MP0001545_abnormal_hematopoietic_system1.85308099
21MP0005397_hematopoietic_system_phenotyp1.85308099
22MP0005058_abnormal_lysosome_morphology1.84305153
23MP0002877_abnormal_melanocyte_morpholog1.83453464
24MP0003866_abnormal_defecation1.82683958
25MP0004185_abnormal_adipocyte_glucose1.82186953
26MP0005360_urolithiasis1.81063845
27MP0003283_abnormal_digestive_organ1.77961416
28MP0002796_impaired_skin_barrier1.77766871
29MP0005666_abnormal_adipose_tissue1.68172878
30MP0000013_abnormal_adipose_tissue1.65899669
31MP0004947_skin_inflammation1.64417085
32MP0003763_abnormal_thymus_physiology1.62665117
33MP0002398_abnormal_bone_marrow1.61582345
34MP0003656_abnormal_erythrocyte_physiolo1.57180503
35MP0010352_gastrointestinal_tract_polyps1.56983930
36MP0009278_abnormal_bone_marrow1.53007564
37MP0001348_abnormal_lacrimal_gland1.52188344
38MP0001790_abnormal_immune_system1.51652690
39MP0005387_immune_system_phenotype1.51652690
40MP0002693_abnormal_pancreas_physiology1.51192878
41MP0005310_abnormal_salivary_gland1.50348686
42MP0005076_abnormal_cell_differentiation1.50294145
43MP0002009_preneoplasia1.50224685
44MP0004381_abnormal_hair_follicle1.48307600
45MP0003453_abnormal_keratinocyte_physiol1.46673304
46MP0001819_abnormal_immune_cell1.45969911
47MP0002420_abnormal_adaptive_immunity1.45337455
48MP0001800_abnormal_humoral_immune1.43888046
49MP0005000_abnormal_immune_tolerance1.43346183
50MP0002723_abnormal_immune_serum1.40021080
51MP0004510_myositis1.39358028
52MP0002722_abnormal_immune_system1.38822606
53MP0003724_increased_susceptibility_to1.38395445
54MP0009333_abnormal_splenocyte_physiolog1.37692375
55MP0002452_abnormal_antigen_presenting1.35441191
56MP0000716_abnormal_immune_system1.33813818
57MP0000751_myopathy1.33652212
58MP0000703_abnormal_thymus_morphology1.33522267
59MP0000858_altered_metastatic_potential1.31283546
60MP0005464_abnormal_platelet_physiology1.30168430
61MP0000689_abnormal_spleen_morphology1.29802789
62MP0002429_abnormal_blood_cell1.28283495
63MP0005375_adipose_tissue_phenotype1.28054650
64MP0009379_abnormal_foot_pigmentation1.26670218
65MP0002249_abnormal_larynx_morphology1.25978734
66MP0000465_gastrointestinal_hemorrhage1.25785030
67MP0004264_abnormal_extraembryonic_tissu1.24994333
68MP0010155_abnormal_intestine_physiology1.22468297
69MP0005409_darkened_coat_color1.20454387
70MP0005671_abnormal_response_to1.19377691
71MP0000358_abnormal_cell_content/1.19252835
72MP0005083_abnormal_biliary_tract1.18629828
73MP0001944_abnormal_pancreas_morphology1.18326917
74MP0004811_abnormal_neuron_physiology1.17060841
75MP0000490_abnormal_crypts_of1.16975575
76MP0005025_abnormal_response_to1.15938675
77MP0005501_abnormal_skin_physiology1.14920289
78MP0000537_abnormal_urethra_morphology1.13899582
79MP0002419_abnormal_innate_immunity1.12840114
80MP0002822_catalepsy1.11859347
81MP0001873_stomach_inflammation1.11766111
82MP0000747_muscle_weakness1.11578472
83MP0001533_abnormal_skeleton_physiology1.11307837
84MP0005670_abnormal_white_adipose1.11081367
85MP0003075_altered_response_to1.10769100
86MP0004808_abnormal_hematopoietic_stem1.09371030
87MP0002089_abnormal_postnatal_growth/wei1.08934080
88MP0002928_abnormal_bile_duct1.08896290
89MP0000681_abnormal_thyroid_gland1.08173474
90MP0003693_abnormal_embryo_hatching1.07820783
91MP0003191_abnormal_cellular_cholesterol1.07389670
92MP0002998_abnormal_bone_remodeling1.07167876
93MP0001845_abnormal_inflammatory_respons1.06912327
94MP0009785_altered_susceptibility_to1.00175925
95MP0002166_altered_tumor_susceptibility1.00063640
96MP0005220_abnormal_exocrine_pancreas0.99413562
97MP0003635_abnormal_synaptic_transmissio0.98314817
98MP0003879_abnormal_hair_cell0.98177612
99MP0005166_decreased_susceptibility_to0.97907610
100MP0002234_abnormal_pharynx_morphology0.94676789
101MP0008007_abnormal_cellular_replicative0.94391085
102MP0003091_abnormal_cell_migration0.94356538
103MP0003566_abnormal_cell_adhesion0.93967313
104MP0005645_abnormal_hypothalamus_physiol0.92962884
105MP0002078_abnormal_glucose_homeostasis0.92645808
106MP0000759_abnormal_skeletal_muscle0.92512520
107MP0001851_eye_inflammation0.91861146
108MP0010307_abnormal_tumor_latency0.90831255
109MP0004130_abnormal_muscle_cell0.90602064
110MP0005423_abnormal_somatic_nervous0.87846344
111MP0002138_abnormal_hepatobiliary_system0.87701799
112MP0002933_joint_inflammation0.87569984
113MP0001849_ear_inflammation0.87550437
114MP0002148_abnormal_hypersensitivity_rea0.86725842
115MP0002405_respiratory_system_inflammati0.86409964
116MP0001853_heart_inflammation0.85894784
117MP0002254_reproductive_system_inflammat0.85779895
118MP0008469_abnormal_protein_level0.85476744
119MP0009931_abnormal_skin_appearance0.85412151
120MP0004233_abnormal_muscle_weight0.85114504
121MP0000003_abnormal_adipose_tissue0.84981964
122MP0004957_abnormal_blastocyst_morpholog0.83928807
123MP0000609_abnormal_liver_physiology0.83033252
124MP0000313_abnormal_cell_death0.82567303
125MP0002269_muscular_atrophy0.82336252
126MP0002132_abnormal_respiratory_system0.79486429
127MP0000678_abnormal_parathyroid_gland0.78582848
128MP0000477_abnormal_intestine_morphology0.78429803
129MP0000733_abnormal_muscle_development0.78129336
130MP0001663_abnormal_digestive_system0.77730551
131MP0001730_embryonic_growth_arrest0.77711425
132MP0003279_aneurysm0.77135576
133MP0003705_abnormal_hypodermis_morpholog0.76036238
134MP0000955_abnormal_spinal_cord0.75786991
135MP0008874_decreased_physiological_sensi0.75749593
136MP0002970_abnormal_white_adipose0.75590134
137MP0004087_abnormal_muscle_fiber0.75240249
138MP0003828_pulmonary_edema0.75157586
139MP0005621_abnormal_cell_physiology0.74818066
140MP0005384_cellular_phenotype0.73165044
141MP0008872_abnormal_physiological_respon0.72166179
142MP0002080_prenatal_lethality0.71522608
143MP0008770_decreased_survivor_rate0.69285645

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.08048761
2Centrally nucleated skeletal muscle fibers (HP:0003687)3.51542015
3Cellulitis (HP:0100658)3.50946739
4Chronic otitis media (HP:0000389)3.44611712
5Dysostosis multiplex (HP:0000943)3.22812183
6Hand muscle atrophy (HP:0009130)3.17725710
7Obstructive sleep apnea (HP:0002870)3.13501930
8Hyperacusis (HP:0010780)3.07661278
9Urinary glycosaminoglycan excretion (HP:0003541)3.03314848
10Mucopolysacchariduria (HP:0008155)3.03314848
11Nasal polyposis (HP:0100582)3.01441099
12Abnormality of polysaccharide metabolism (HP:0011012)2.97393087
13Abnormality of glycosaminoglycan metabolism (HP:0004371)2.97393087
14Abnormality of mucopolysaccharide metabolism (HP:0011020)2.97393087
15Neoplasm of the heart (HP:0100544)2.97171978
16Abnormal delayed hypersensitivity skin test (HP:0002963)2.94795427
17Exercise-induced myalgia (HP:0003738)2.93763716
18Increased cerebral lipofuscin (HP:0011813)2.91921486
19Abnormality of the nasal mucosa (HP:0000433)2.88963486
20Upper limb amyotrophy (HP:0009129)2.79374768
21Distal upper limb amyotrophy (HP:0007149)2.79374768
22Cerebral aneurysm (HP:0004944)2.78559597
23Microretrognathia (HP:0000308)2.75391889
24Abnormality of glycolipid metabolism (HP:0010969)2.73840462
25Abnormality of liposaccharide metabolism (HP:0010968)2.73840462
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.73840462
27Myopathic facies (HP:0002058)2.73213807
28Insomnia (HP:0100785)2.67585032
29Increased variability in muscle fiber diameter (HP:0003557)2.64069633
30Fatigue (HP:0012378)2.60755834
31Hemorrhage of the eye (HP:0011885)2.58848524
32Visual hallucinations (HP:0002367)2.58153052
33Ependymoma (HP:0002888)2.57783957
34Distal lower limb amyotrophy (HP:0008944)2.54003526
35Agammaglobulinemia (HP:0004432)2.53808674
36Atrophy/Degeneration involving motor neurons (HP:0007373)2.52196165
37Gastrointestinal stroma tumor (HP:0100723)2.51410133
38Gastrointestinal inflammation (HP:0004386)2.51051360
39Distal lower limb muscle weakness (HP:0009053)2.50716275
40Increased connective tissue (HP:0009025)2.50013306
41Colitis (HP:0002583)2.48071394
42Hypercortisolism (HP:0001578)2.46129624
43Pointed chin (HP:0000307)2.45355792
44Abnormality of the motor neurons (HP:0002450)2.44118225
45Abnormal neuron morphology (HP:0012757)2.44118225
46Abnormality of skeletal muscle fiber size (HP:0012084)2.43996415
47Late onset (HP:0003584)2.43338098
48Degeneration of anterior horn cells (HP:0002398)2.41736850
49Abnormality of the anterior horn cell (HP:0006802)2.41736850
50Deep palmar crease (HP:0006191)2.38441684
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37960659
52Bulbar palsy (HP:0001283)2.37583646
53Obstructive lung disease (HP:0006536)2.34709988
54Chronic obstructive pulmonary disease (HP:0006510)2.34709988
55Supranuclear gaze palsy (HP:0000605)2.31988134
56Meningitis (HP:0001287)2.31400009
57Stridor (HP:0010307)2.29805035
58Thrombocytosis (HP:0001894)2.27759717
59Diminished motivation (HP:0000745)2.26835282
60Recurrent bronchitis (HP:0002837)2.26307338
61Amyotrophic lateral sclerosis (HP:0007354)2.25941302
62Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.25532199
63Hypoglycemic seizures (HP:0002173)2.25435740
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.25336467
65Easy fatigability (HP:0003388)2.24060913
66Abnormality of the fingertips (HP:0001211)2.23838123
67Panhypogammaglobulinemia (HP:0003139)2.22619108
68Loss of speech (HP:0002371)2.20100264
69Recurrent abscess formation (HP:0002722)2.19820369
70Large eyes (HP:0001090)2.19529816
71Elevated erythrocyte sedimentation rate (HP:0003565)2.19234624
72Flat acetabular roof (HP:0003180)2.18469271
73Mediastinal lymphadenopathy (HP:0100721)2.17974833
74Increased IgE level (HP:0003212)2.17861551
75Emphysema (HP:0002097)2.17211698
76Papilledema (HP:0001085)2.17035828
77Abnormality of T cell physiology (HP:0011840)2.16267857
78Spontaneous hematomas (HP:0007420)2.16240990
79Polygenic inheritance (HP:0010982)2.15279484
80Interstitial pulmonary disease (HP:0006530)2.14780221
81Abnormality of small intestinal villus morphology (HP:0011472)2.14227502
82Villous atrophy (HP:0011473)2.14227502
83Apathy (HP:0000741)2.13951017
84Vacuolated lymphocytes (HP:0001922)2.13805286
85Thin bony cortex (HP:0002753)2.12252596
86Growth hormone excess (HP:0000845)2.12165974
87Thoracic kyphosis (HP:0002942)2.11128686
88Abnormality of macrophages (HP:0004311)2.10344372
89Hyperinsulinemic hypoglycemia (HP:0000825)2.09727284
90Inflammation of the large intestine (HP:0002037)2.09004611
91Gingivitis (HP:0000230)2.05908222
92Severe short stature (HP:0003510)2.04565089
93Segmental peripheral demyelination/remyelination (HP:0003481)2.04293372
94Broad face (HP:0000283)2.03954502
95Abnormality of the thoracic spine (HP:0100711)2.03842707
96Abnormal number of erythroid precursors (HP:0012131)2.03793816
97Recurrent bacterial skin infections (HP:0005406)2.03275914
98Recurrent viral infections (HP:0004429)1.97749085
99Ankle clonus (HP:0011448)1.97558129
100Abnormality of the lower motor neuron (HP:0002366)1.96825041
101Long toe (HP:0010511)1.94804476
102Depression (HP:0000716)1.94339030
103Vertebral compression fractures (HP:0002953)1.93571541
104Abnormality of endocrine pancreas physiology (HP:0012093)1.92287072
105Abnormality of the pancreatic islet cells (HP:0006476)1.92287072
106Abnormality of cells of the erythroid lineage (HP:0012130)1.91852525
107Seborrheic dermatitis (HP:0001051)1.91788951
108Achilles tendon contracture (HP:0001771)1.89607704
109Hypertriglyceridemia (HP:0002155)1.88735324
110Ragged-red muscle fibers (HP:0003200)1.87747480
111Hypertensive crisis (HP:0100735)1.87211521
112Gastrointestinal dysmotility (HP:0002579)1.87064358
113Germ cell neoplasia (HP:0100728)1.86757778
114Ketoacidosis (HP:0001993)1.85001486
115Foot dorsiflexor weakness (HP:0009027)1.84558354
116Hyporeflexia of lower limbs (HP:0002600)1.83525193
117Global brain atrophy (HP:0002283)1.82178633
118Progressive muscle weakness (HP:0003323)1.82089222
119Premature skin wrinkling (HP:0100678)1.81710749
120Gastrointestinal infarctions (HP:0005244)1.81314568
121Rhabdomyolysis (HP:0003201)1.80472655
122Striae distensae (HP:0001065)1.80189341
123Radial bowing (HP:0002986)1.79880082
124Pustule (HP:0200039)1.79821059
125Abnormality of T cells (HP:0002843)1.79597722
126Recurrent fungal infections (HP:0002841)1.79342940
127Personality changes (HP:0000751)1.79316857
128Spinal canal stenosis (HP:0003416)1.79157767
129Abnormality of oral frenula (HP:0000190)1.78983026
130Restrictive lung disease (HP:0002091)1.78371427
131Gout (HP:0001997)1.78207996
132Angiofibromas (HP:0010615)1.77628286
133Adenoma sebaceum (HP:0009720)1.77628286
134Difficulty climbing stairs (HP:0003551)1.77394754
135IgM deficiency (HP:0002850)1.77389031
136Elfin facies (HP:0004428)1.77352467
137Rectal prolapse (HP:0002035)1.76706746
138Hypoplasia of the pons (HP:0012110)1.76360061
139Acanthosis nigricans (HP:0000956)1.75985259
140Chronic mucocutaneous candidiasis (HP:0002728)1.74783435
141Recurrent cutaneous fungal infections (HP:0011370)1.74783435
142J-shaped sella turcica (HP:0002680)1.74164500
143Long palpebral fissure (HP:0000637)1.72940641
144Myositis (HP:0100614)1.72228775
145Abnormality of the Achilles tendon (HP:0005109)1.71921000
146Abnormality of the columella (HP:0009929)1.71296957
147Mildly elevated creatine phosphokinase (HP:0008180)1.70779155
148Peripheral hypomyelination (HP:0007182)1.70620182
149Recurrent gram-negative bacterial infections (HP:0005420)1.70126853
150Lymphangioma (HP:0100764)1.69648904
151Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.69187226
152Limb-girdle muscle atrophy (HP:0003797)1.69159578
153Slow saccadic eye movements (HP:0000514)1.69094332
154Hypoglycemic coma (HP:0001325)1.68900324
155Annular pancreas (HP:0001734)1.68741786
156Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68569907
157Failure to thrive in infancy (HP:0001531)1.68302503
158Chest pain (HP:0100749)1.66540757
159Poikiloderma (HP:0001029)1.66204849
160Verrucae (HP:0200043)1.65684167
161Papilloma (HP:0012740)1.65684167
162Onion bulb formation (HP:0003383)1.65514105
163Axonal loss (HP:0003447)1.65503709
164Visceral angiomatosis (HP:0100761)1.65109978
165Osteomyelitis (HP:0002754)1.64847988
166Malnutrition (HP:0004395)1.63940883
167Abnormality of the foot musculature (HP:0001436)1.63300433
168Neuronal loss in central nervous system (HP:0002529)1.62710161
169Prolonged bleeding time (HP:0003010)1.60996293
170Systemic lupus erythematosus (HP:0002725)1.60911844
171Urticaria (HP:0001025)1.60644566
172Difficulty running (HP:0009046)1.60170326
173Lower limb amyotrophy (HP:0007210)1.59417397
174Purpura (HP:0000979)1.58998570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.95824943
2TRIB33.57799761
3PRPF4B3.50757401
4MAP3K102.98845725
5SMG12.91633399
6MAP3K132.60337156
7SCYL22.57155039
8PKN22.56445558
9MAP3K92.40784472
10EEF2K2.29262261
11MAP4K12.09357277
12BLK2.07338661
13TNK21.97013193
14PASK1.89444795
15SIK31.81186384
16INSRR1.74154012
17GRK61.70196098
18NME21.65517019
19KSR21.64922332
20TESK21.62113437
21FLT31.61847330
22ZAP701.55815557
23SIK21.54172692
24MAP3K71.52663115
25TBK11.51764145
26NTRK11.51083515
27CAMKK11.42890042
28SIK11.40806780
29RIPK11.37463000
30IRAK31.36243754
31DYRK1B1.35928832
32TAOK31.30325133
33LRRK21.26130388
34TTN1.25123629
35PAK41.23320983
36IRAK41.23105393
37CDK121.17381246
38DAPK11.16147911
39HIPK21.15645516
40EPHA21.14573969
41CAMKK21.08840264
42CDK191.07513365
43TYK21.06995946
44KSR11.06524037
45FGFR41.03756171
46TGFBR21.02994024
47MAP3K31.02739475
48PTK61.00038536
49MAP3K20.99749739
50MAPK120.98852672
51SYK0.97786677
52NEK10.97154059
53TESK10.96634060
54PDPK10.95300098
55ICK0.95127126
56ALK0.94686164
57PRKD30.93870476
58MATK0.93120348
59EPHB10.92210097
60MAPK150.90291685
61MARK20.89239703
62TAOK20.89089823
63MINK10.88973364
64JAK30.87985217
65RPS6KC10.87884177
66RPS6KL10.87884177
67TAOK10.86341083
68PDGFRA0.86146617
69DYRK30.85259800
70TYRO30.83491793
71BTK0.82479256
72DAPK20.81545107
73RAF10.80637724
74BCKDK0.80566106
75RET0.77644551
76KDR0.77330442
77MAP3K110.76962526
78MAPKAPK30.75244777
79CDC42BPA0.74793004
80ARAF0.73894901
81EPHA30.73694495
82CSF1R0.73144085
83PDK10.72107740
84JAK10.71969137
85JAK20.70246924
86LMTK20.69306981
87BRAF0.68012309
88NTRK30.67880418
89RPS6KA60.65578790
90PRKG20.65397381
91PIM20.64431473
92CSK0.64171096
93MAPK110.63503278
94MAP3K10.63340566
95MAP3K60.63038423
96UHMK10.61257937
97IRAK20.57950041
98BRSK10.55819167
99MAP2K30.54986676
100MAP2K20.53050221
101RPS6KA20.52906098
102PRKCI0.52496222
103RPS6KA40.51858556
104PTK20.51395518
105MAPK70.50454489
106PAK60.49823313
107CAMK10.49287037
108PRKCH0.47814964
109RIPK40.47669286
110CAMK40.47642516
111MARK30.47531786
112DAPK30.46938393
113BMX0.46365564
114RPS6KB20.46180894
115HCK0.44840934
116STK100.44159704
117MAP2K60.42812991
118PRKD20.41226672
119MAPK40.41164961
120NEK20.40557550
121CDK40.40272008
122IRAK10.39830699
123KIT0.39499685
124RPS6KA10.38748558
125MAP3K80.38448528
126MTOR0.38133851
127IKBKE0.37382829
128MAP3K140.37173937
129FES0.36652218
130MOS0.36343238
131PRKD10.35384331
132LCK0.35205495
133CAMK1D0.34385074
134MAPK90.34349918
135LYN0.33226990
136NTRK20.32925297
137ITK0.32863638
138STK380.32700752
139ILK0.32528965
140MAPKAPK20.27754158

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.86344572
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.78191098
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22874371
4B cell receptor signaling pathway_Homo sapiens_hsa046621.96734092
5Antigen processing and presentation_Homo sapiens_hsa046121.79038971
6Cyanoamino acid metabolism_Homo sapiens_hsa004601.77660433
7Sulfur relay system_Homo sapiens_hsa041221.77306334
8N-Glycan biosynthesis_Homo sapiens_hsa005101.73480318
9Lysosome_Homo sapiens_hsa041421.71615609
10Synaptic vesicle cycle_Homo sapiens_hsa047211.70052525
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.66214591
12Neurotrophin signaling pathway_Homo sapiens_hsa047221.65738579
13Chronic myeloid leukemia_Homo sapiens_hsa052201.62815177
14Primary immunodeficiency_Homo sapiens_hsa053401.54669773
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53176188
16Acute myeloid leukemia_Homo sapiens_hsa052211.52786839
17Pentose phosphate pathway_Homo sapiens_hsa000301.49450376
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46689541
19Type II diabetes mellitus_Homo sapiens_hsa049301.45244998
20Allograft rejection_Homo sapiens_hsa053301.45191922
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44552910
22Shigellosis_Homo sapiens_hsa051311.43257360
23mTOR signaling pathway_Homo sapiens_hsa041501.41269365
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41089668
25Autoimmune thyroid disease_Homo sapiens_hsa053201.40327084
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39971145
27Galactose metabolism_Homo sapiens_hsa000521.31950486
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.31623486
29Insulin secretion_Homo sapiens_hsa049111.30532473
30Osteoclast differentiation_Homo sapiens_hsa043801.30176784
31Viral myocarditis_Homo sapiens_hsa054161.28692290
32T cell receptor signaling pathway_Homo sapiens_hsa046601.26476535
33VEGF signaling pathway_Homo sapiens_hsa043701.23920587
34Graft-versus-host disease_Homo sapiens_hsa053321.23216954
35Fructose and mannose metabolism_Homo sapiens_hsa000511.22583682
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22094216
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19959632
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19316710
39Leishmaniasis_Homo sapiens_hsa051401.15350768
40Notch signaling pathway_Homo sapiens_hsa043301.13953115
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13201417
42Other glycan degradation_Homo sapiens_hsa005111.12108979
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11744958
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11167817
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09550467
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09269210
47Prolactin signaling pathway_Homo sapiens_hsa049171.07962134
48Apoptosis_Homo sapiens_hsa042101.07772685
49GnRH signaling pathway_Homo sapiens_hsa049121.07678961
50Legionellosis_Homo sapiens_hsa051341.06330049
51Staphylococcus aureus infection_Homo sapiens_hsa051501.05422540
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.04424249
53Hepatitis C_Homo sapiens_hsa051601.03668699
54Thyroid cancer_Homo sapiens_hsa052161.01874000
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01714097
56DNA replication_Homo sapiens_hsa030301.01247749
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00260116
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98807758
59Insulin signaling pathway_Homo sapiens_hsa049100.98434806
60Bladder cancer_Homo sapiens_hsa052190.98164426
61Biosynthesis of amino acids_Homo sapiens_hsa012300.96254721
62Non-small cell lung cancer_Homo sapiens_hsa052230.94794422
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.94716708
64Systemic lupus erythematosus_Homo sapiens_hsa053220.94571883
65Choline metabolism in cancer_Homo sapiens_hsa052310.93764352
66Insulin resistance_Homo sapiens_hsa049310.93441017
67Renal cell carcinoma_Homo sapiens_hsa052110.93043614
68AMPK signaling pathway_Homo sapiens_hsa041520.92273268
69Prion diseases_Homo sapiens_hsa050200.91838532
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.91758022
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91005335
72Colorectal cancer_Homo sapiens_hsa052100.89295010
73Glioma_Homo sapiens_hsa052140.87989541
74Endocytosis_Homo sapiens_hsa041440.87829178
75Long-term potentiation_Homo sapiens_hsa047200.87710431
76Type I diabetes mellitus_Homo sapiens_hsa049400.86720026
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86540121
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.86008201
79Hepatitis B_Homo sapiens_hsa051610.85383269
80Epstein-Barr virus infection_Homo sapiens_hsa051690.84820881
81Inositol phosphate metabolism_Homo sapiens_hsa005620.83282856
82Estrogen signaling pathway_Homo sapiens_hsa049150.81173561
83Pertussis_Homo sapiens_hsa051330.81009282
84Vibrio cholerae infection_Homo sapiens_hsa051100.78865226
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.77445014
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77109882
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.76377595
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75922768
89HTLV-I infection_Homo sapiens_hsa051660.75479627
90Influenza A_Homo sapiens_hsa051640.74550218
91Tuberculosis_Homo sapiens_hsa051520.74536303
92Asthma_Homo sapiens_hsa053100.74209534
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73124870
94Spliceosome_Homo sapiens_hsa030400.72531998
95Toxoplasmosis_Homo sapiens_hsa051450.71642086
96Salmonella infection_Homo sapiens_hsa051320.71523527
97Herpes simplex infection_Homo sapiens_hsa051680.69938903
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69646963
99Prostate cancer_Homo sapiens_hsa052150.67739543
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66513632
101Viral carcinogenesis_Homo sapiens_hsa052030.66492322
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.66283659
103Dopaminergic synapse_Homo sapiens_hsa047280.65680424
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64928718
105Pancreatic cancer_Homo sapiens_hsa052120.64880805
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64783861
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62007939
108Alcoholism_Homo sapiens_hsa050340.61377514
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59871356
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59533112
111HIF-1 signaling pathway_Homo sapiens_hsa040660.59416312
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56704058
113Measles_Homo sapiens_hsa051620.56619225
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56428083
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56056287
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55637641
117TNF signaling pathway_Homo sapiens_hsa046680.54574431
118Gap junction_Homo sapiens_hsa045400.54371769
119Ribosome_Homo sapiens_hsa030100.53019266
120ErbB signaling pathway_Homo sapiens_hsa040120.52887996
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52500602
122Endometrial cancer_Homo sapiens_hsa052130.50716636
123Renin-angiotensin system_Homo sapiens_hsa046140.49893690
124Platelet activation_Homo sapiens_hsa046110.47694856
125Olfactory transduction_Homo sapiens_hsa047400.47129615
126Glucagon signaling pathway_Homo sapiens_hsa049220.46934152
127Oxytocin signaling pathway_Homo sapiens_hsa049210.46285974
128Folate biosynthesis_Homo sapiens_hsa007900.46075620
129Chemokine signaling pathway_Homo sapiens_hsa040620.45773942
130Circadian entrainment_Homo sapiens_hsa047130.45575305
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44239317

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