VPS52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.77685542
2proline biosynthetic process (GO:0006561)4.61643735
3positive regulation of gamma-delta T cell activation (GO:0046645)4.59422650
4regulation of gamma-delta T cell differentiation (GO:0045586)4.55702029
5negative regulation of cell size (GO:0045792)4.47920883
6antigen processing and presentation via MHC class Ib (GO:0002475)4.43361255
7glucose 6-phosphate metabolic process (GO:0051156)4.11886603
8spliceosomal tri-snRNP complex assembly (GO:0000244)4.05731613
9positive thymic T cell selection (GO:0045059)4.01087060
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.98135672
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98135672
12positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.93268159
13regulation of gamma-delta T cell activation (GO:0046643)3.86485926
14positive regulation of lamellipodium assembly (GO:0010592)3.85212183
15barbed-end actin filament capping (GO:0051016)3.68363866
16vesicle coating (GO:0006901)3.63113568
17synaptic vesicle maturation (GO:0016188)3.62871256
18antigen processing and presentation of endogenous antigen (GO:0019883)3.61260759
19regulation of translational fidelity (GO:0006450)3.60103340
20proline metabolic process (GO:0006560)3.54791225
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.49330798
22COPII vesicle coating (GO:0048208)3.47592296
23pentose-phosphate shunt (GO:0006098)3.47147580
24gluconeogenesis (GO:0006094)3.46792522
25regulation of ARF GTPase activity (GO:0032312)3.45869462
26thymic T cell selection (GO:0045061)3.45674225
27regulation of synapse structural plasticity (GO:0051823)3.45604176
28peptidyl-arginine omega-N-methylation (GO:0035247)3.45093796
29negative regulation of erythrocyte differentiation (GO:0045647)3.44780728
30natural killer cell differentiation (GO:0001779)3.42040024
31monosaccharide biosynthetic process (GO:0046364)3.41153946
32sodium ion export (GO:0071436)3.40988593
33glycolytic process (GO:0006096)3.36500030
34COPI coating of Golgi vesicle (GO:0048205)3.34979628
35Golgi transport vesicle coating (GO:0048200)3.34979628
36positive regulation of histone deacetylation (GO:0031065)3.34650849
37positive regulation of lamellipodium organization (GO:1902745)3.33989105
38regulation of defense response to virus by virus (GO:0050690)3.31461260
39hexose biosynthetic process (GO:0019319)3.30981183
40pentose metabolic process (GO:0019321)3.30380000
41mannose metabolic process (GO:0006013)3.29675738
42negative thymic T cell selection (GO:0045060)3.26307495
43protein maturation by protein folding (GO:0022417)3.25537396
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.25521897
45DNA deamination (GO:0045006)3.18984815
46negative regulation of cell killing (GO:0031342)3.18183364
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18183364
48glutamine family amino acid biosynthetic process (GO:0009084)3.16386979
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14893518
50regulation of cholesterol metabolic process (GO:0090181)3.14691541
51response to interleukin-15 (GO:0070672)3.14238283
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12880782
53regulation of cholesterol biosynthetic process (GO:0045540)3.12549773
54regulation of nucleobase-containing compound transport (GO:0032239)3.10874771
55endothelial tube morphogenesis (GO:0061154)3.06743882
56morphogenesis of an endothelium (GO:0003159)3.06743882
57negative T cell selection (GO:0043383)3.06495426
58maintenance of protein localization in organelle (GO:0072595)3.02957255
59nucleosome disassembly (GO:0006337)2.98231475
60protein-DNA complex disassembly (GO:0032986)2.98231475
61T cell selection (GO:0045058)2.95564614
62ncRNA 3-end processing (GO:0043628)2.95483808
63glucose catabolic process (GO:0006007)2.93622936
64intracellular estrogen receptor signaling pathway (GO:0030520)2.93257387
65regulation of RNA export from nucleus (GO:0046831)2.92283874
66regulation of extracellular matrix disassembly (GO:0010715)2.89972869
67snRNA metabolic process (GO:0016073)2.89866354
68negative regulation of microtubule polymerization (GO:0031115)2.89336358
69peptidyl-arginine N-methylation (GO:0035246)2.87445869
70peptidyl-arginine methylation (GO:0018216)2.87445869
71positive regulation of B cell differentiation (GO:0045579)2.85952823
72positive T cell selection (GO:0043368)2.85626896
73poly(A)+ mRNA export from nucleus (GO:0016973)2.85384608
74NADH metabolic process (GO:0006734)2.85379444
75dicarboxylic acid biosynthetic process (GO:0043650)2.85267985
76fructose metabolic process (GO:0006000)2.84471828
77locomotory exploration behavior (GO:0035641)2.84410292
78negative regulation of myotube differentiation (GO:0010832)2.83549338
79cytoskeletal anchoring at plasma membrane (GO:0007016)2.83307287
80cerebellar Purkinje cell layer development (GO:0021680)2.83179943
81regulation of ARF protein signal transduction (GO:0032012)2.82653884
82positive regulation of Cdc42 GTPase activity (GO:0043089)2.82244130
83regulation of autophagic vacuole assembly (GO:2000785)2.81079495
84signal complex assembly (GO:0007172)2.80162641
85protein retention in ER lumen (GO:0006621)2.79128223
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78901136
87regulation of type I interferon-mediated signaling pathway (GO:0060338)2.78752293
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.78520385
89NADPH regeneration (GO:0006740)2.78076739
90oxaloacetate metabolic process (GO:0006107)2.77492714
91creatine metabolic process (GO:0006600)2.77444123
92localization within membrane (GO:0051668)2.76103380
93snRNA processing (GO:0016180)2.75902085
94endoplasmic reticulum unfolded protein response (GO:0030968)2.75753747
95regulation of nuclease activity (GO:0032069)2.75423679
96positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74310454
97cell communication by electrical coupling (GO:0010644)2.73307117
98regulation of NFAT protein import into nucleus (GO:0051532)2.73300321
99regulation of mitotic spindle organization (GO:0060236)2.73104290
100stress fiber assembly (GO:0043149)2.71960903
101histone H4 deacetylation (GO:0070933)2.70895243
102maternal placenta development (GO:0001893)2.70192883
103B cell receptor signaling pathway (GO:0050853)2.69233659
104regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.68539239
105tricarboxylic acid metabolic process (GO:0072350)2.67093028
106actin filament depolymerization (GO:0030042)2.66982271
107DNA unwinding involved in DNA replication (GO:0006268)2.66832743
108leukocyte aggregation (GO:0070486)2.64863305
109Peyers patch development (GO:0048541)2.64427180
110mucosal-associated lymphoid tissue development (GO:0048537)2.64427180
111positive regulation of Rap GTPase activity (GO:0032854)2.64254607
112positive regulation of protein deacetylation (GO:0090312)2.63873104
113desmosome organization (GO:0002934)2.62767040
114epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62436099
115regulation of Rap GTPase activity (GO:0032317)2.62331527
116regulation of histone H3-K27 methylation (GO:0061085)2.61688182
117activation of JUN kinase activity (GO:0007257)2.61608312
118sarcomere organization (GO:0045214)2.61554761
119negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61278067
120semaphorin-plexin signaling pathway (GO:0071526)2.60905035
121cell volume homeostasis (GO:0006884)2.59505249
122protein export from nucleus (GO:0006611)2.57788260
123positive regulation of triglyceride biosynthetic process (GO:0010867)2.57759334
124cellular response to unfolded protein (GO:0034620)2.57414671
125adherens junction assembly (GO:0034333)2.56652780
126negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.56559608
127regulation of B cell differentiation (GO:0045577)2.56171827
128activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55930030
129retrograde transport, endosome to Golgi (GO:0042147)2.55289289
130plasma membrane repair (GO:0001778)2.54718895
131negative regulation of nucleotide catabolic process (GO:0030812)2.54632631
132ER-nucleus signaling pathway (GO:0006984)2.54531796
133positive regulation of nuclease activity (GO:0032075)2.54292079
134cellular response to zinc ion (GO:0071294)2.53489000
135glucocorticoid receptor signaling pathway (GO:0042921)2.53071181
136cell-substrate adherens junction assembly (GO:0007045)2.53015691
137focal adhesion assembly (GO:0048041)2.53015691
138regulation of B cell receptor signaling pathway (GO:0050855)2.52522925
139regulation of mammary gland epithelial cell proliferation (GO:0033599)2.51816083
1404-hydroxyproline metabolic process (GO:0019471)2.50687118
141positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.50582866
142positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.49844161
143regulation of early endosome to late endosome transport (GO:2000641)2.49411969
144galactose catabolic process (GO:0019388)2.46090578
145positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.45685640
146cellular response to topologically incorrect protein (GO:0035967)2.45590107
147protoporphyrinogen IX metabolic process (GO:0046501)2.45522015
148tricarboxylic acid cycle (GO:0006099)2.45237289
149activation of protein kinase A activity (GO:0034199)2.45132582
150regulation of amyloid precursor protein catabolic process (GO:1902991)2.44007762
151protein insertion into membrane (GO:0051205)2.43548298
152cellular response to interleukin-4 (GO:0071353)2.42661872
153negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.40941413
154endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.40761019
155regulation of vacuole organization (GO:0044088)2.40464623
156regulation of interleukin-12 biosynthetic process (GO:0045075)2.39520136
157folic acid metabolic process (GO:0046655)2.39318751
158maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.38604463
159cellular hyperosmotic response (GO:0071474)2.37316928
160immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.37050555
161Fc-gamma receptor signaling pathway (GO:0038094)2.37050555
162Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.37050555
163protein localization to endosome (GO:0036010)2.37024459
164modulation by virus of host morphology or physiology (GO:0019048)2.36740871
165regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.35501239
1663-UTR-mediated mRNA stabilization (GO:0070935)2.35212795
167mitotic G1 DNA damage checkpoint (GO:0031571)2.34672753
168virion assembly (GO:0019068)2.34569211
169erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.34138313
170L-phenylalanine metabolic process (GO:0006558)2.34138313
171cellular response to interleukin-15 (GO:0071350)2.34111514
172megakaryocyte development (GO:0035855)2.34030339
173regulation of cholesterol homeostasis (GO:2000188)2.33930592
174mitotic chromosome condensation (GO:0007076)2.33658467
175Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.32749040
176regulation of short-term neuronal synaptic plasticity (GO:0048172)2.32461994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.79417491
2VDR_21846776_ChIP-Seq_THP-1_Human3.06973942
3LXR_22292898_ChIP-Seq_THP-1_Human2.81232151
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72447630
5* KDM2B_26808549_Chip-Seq_DND41_Human2.46627955
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.42276124
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.34736071
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32481333
9* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31919481
10TCF7_22412390_ChIP-Seq_EML_Mouse2.26190978
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23042062
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16919444
13MAF_26560356_Chip-Seq_TH1_Human2.15825443
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13862826
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11032204
16UTX_26944678_Chip-Seq_JUKART_Human2.07881278
17* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01580488
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00235251
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99961928
20P68_20966046_ChIP-Seq_HELA_Human1.98034020
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96961352
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94363526
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93365880
24CLOCK_20551151_ChIP-Seq_293T_Human1.86385132
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84637798
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80050017
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.76511569
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75770534
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74392507
30VDR_24763502_ChIP-Seq_THP-1_Human1.73784521
31* CIITA_25753668_ChIP-Seq_RAJI_Human1.73117387
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71920475
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71085494
34* SPI1_23127762_ChIP-Seq_K562_Human1.70134422
35BCL6_27268052_Chip-Seq_Bcells_Human1.68792345
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.68447815
37RACK7_27058665_Chip-Seq_MCF-7_Human1.60793790
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60757854
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60456219
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.59593879
41MAF_26560356_Chip-Seq_TH2_Human1.58686148
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.58637736
43BCOR_27268052_Chip-Seq_Bcells_Human1.58387550
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57694499
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.51094777
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48399556
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.47464232
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47326569
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.47254091
50SCL_19346495_ChIP-Seq_HPC-7_Human1.44495065
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.43706865
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42181220
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41578667
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41185513
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40244020
56* KDM2B_26808549_Chip-Seq_K562_Human1.40099382
57PHF8_20622854_ChIP-Seq_HELA_Human1.39480420
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39460764
59* XRN2_22483619_ChIP-Seq_HELA_Human1.38997800
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38756086
61TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38725041
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.38252534
63SMC4_20622854_ChIP-Seq_HELA_Human1.37464351
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.37350210
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35798156
66TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.35704503
67CTCF_21964334_ChIP-Seq_BJAB-B_Human1.35688529
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35382538
69* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34396255
70* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33987190
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33117806
72* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31793056
73E2F1_20622854_ChIP-Seq_HELA_Human1.31168320
74* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29940114
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28772273
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27571952
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.27563475
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26738748
79ZNF263_19887448_ChIP-Seq_K562_Human1.25503426
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24397942
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24015173
82E2F7_22180533_ChIP-Seq_HELA_Human1.23322175
83* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22206095
84SA1_27219007_Chip-Seq_Bcells_Human1.22193184
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22141244
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21831416
87* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21707457
88* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21698013
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21193419
90MYB_26560356_Chip-Seq_TH2_Human1.19693879
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19068099
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.18764198
93* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18757839
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18455547
95RXR_22158963_ChIP-Seq_LIVER_Mouse1.18436967
96* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17204147
97CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17171846
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16861553
99CTCF_21964334_Chip-Seq_Bcells_Human1.16505157
100CREB1_26743006_Chip-Seq_LNCaP_Human1.16363865
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.15670709
102* YY1_22570637_ChIP-Seq_MALME-3M_Human1.15271077
103EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14946702
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14485030
105GATA1_19941826_ChIP-Seq_K562_Human1.14423409
106SPI1_20517297_ChIP-Seq_HL60_Human1.14265024
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14173681
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14171005
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13870181
110ATF3_27146783_Chip-Seq_COLON_Human1.13596756
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13590230
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12486364
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12049893
114MYC_18555785_ChIP-Seq_MESCs_Mouse1.11336115
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11177996
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11036017
117GABP_19822575_ChIP-Seq_HepG2_Human1.10917719
118RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10671568
119SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10166251
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10090910
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09556552
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09192104
123CTCF_26484167_Chip-Seq_Bcells_Mouse1.08885503
124* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08401172
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07399503
126NCOR1_26117541_ChIP-Seq_K562_Human1.07214573
127FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07140621
128CHD1_26751641_Chip-Seq_LNCaP_Human1.05800450
129* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05750120
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05513490
131RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05393359
132P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04732043
133* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04572602
134MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04011784
135KDM5A_27292631_Chip-Seq_BREAST_Human1.03266595
136NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03235318
137* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02712939
138RUNX1_27514584_Chip-Seq_MCF-7_Human1.02459161
139ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02325323
140* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02163510
141RARB_24833708_ChIP-Seq_LIVER_Mouse1.01892592
142NANOG_21062744_ChIP-ChIP_HESCs_Human1.01734510
143TP53_22127205_ChIP-Seq_IMR90_Human1.01287528
144TFEB_21752829_ChIP-Seq_HELA_Human1.00633515
145MYB_26560356_Chip-Seq_TH1_Human1.00137693
146TP63_22573176_ChIP-Seq_HFKS_Human1.00118360
147P300_27268052_Chip-Seq_Bcells_Human0.99577344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.42235006
2MP0008260_abnormal_autophagy3.82429190
3MP0005451_abnormal_body_composition3.72274031
4MP0003303_peritoneal_inflammation2.68783137
5MP0008961_abnormal_basal_metabolism2.64235488
6MP0004381_abnormal_hair_follicle2.53652762
7MP0000685_abnormal_immune_system2.52564781
8MP0005409_darkened_coat_color2.42486338
9MP0003172_abnormal_lysosome_physiology2.41695749
10MP0000751_myopathy2.37778501
11MP0002837_dystrophic_cardiac_calcinosis2.29040808
12MP0002877_abnormal_melanocyte_morpholog2.17161265
13MP0009278_abnormal_bone_marrow2.16682960
14MP0004264_abnormal_extraembryonic_tissu2.15586269
15MP0002822_catalepsy2.10114701
16MP0000749_muscle_degeneration2.09751806
17MP0004185_abnormal_adipocyte_glucose2.08833327
18MP0003763_abnormal_thymus_physiology2.06724451
19MP0009840_abnormal_foam_cell2.01068707
20MP0001849_ear_inflammation2.00582470
21MP0003329_amyloid_beta_deposits1.98756259
22MP0003436_decreased_susceptibility_to1.90726868
23MP0003646_muscle_fatigue1.88680854
24MP0004084_abnormal_cardiac_muscle1.86120378
25MP0002909_abnormal_adrenal_gland1.84332327
26MP0003183_abnormal_peptide_metabolism1.83470589
27MP0001730_embryonic_growth_arrest1.77459413
28MP0004510_myositis1.75715465
29MP0004858_abnormal_nervous_system1.74035253
30MP0005666_abnormal_adipose_tissue1.71870841
31MP0000747_muscle_weakness1.69130152
32MP0002398_abnormal_bone_marrow1.68590261
33MP0003635_abnormal_synaptic_transmissio1.61133051
34MP0001873_stomach_inflammation1.59893649
35MP0005671_abnormal_response_to1.58908266
36MP0002269_muscular_atrophy1.58105174
37MP0005397_hematopoietic_system_phenotyp1.56398052
38MP0001545_abnormal_hematopoietic_system1.56398052
39MP0003111_abnormal_nucleus_morphology1.55042251
40MP0002132_abnormal_respiratory_system1.54868031
41MP0002653_abnormal_ependyma_morphology1.50056109
42MP0003075_altered_response_to1.49562383
43MP0001800_abnormal_humoral_immune1.48395191
44MP0001835_abnormal_antigen_presentation1.47641652
45MP0002396_abnormal_hematopoietic_system1.45976971
46MP0000703_abnormal_thymus_morphology1.43639127
47MP0004036_abnormal_muscle_relaxation1.43557523
48MP0002420_abnormal_adaptive_immunity1.41838038
49MP0004130_abnormal_muscle_cell1.41789063
50MP0002796_impaired_skin_barrier1.40888219
51MP0001819_abnormal_immune_cell1.40502153
52MP0003656_abnormal_erythrocyte_physiolo1.40093899
53MP0003300_gastrointestinal_ulcer1.38441312
54MP0005000_abnormal_immune_tolerance1.37758554
55MP0005058_abnormal_lysosome_morphology1.36182946
56MP0008569_lethality_at_weaning1.35301280
57MP0009780_abnormal_chondrocyte_physiolo1.34935825
58MP0002089_abnormal_postnatal_growth/wei1.34666045
59MP0005670_abnormal_white_adipose1.34480871
60MP0000015_abnormal_ear_pigmentation1.32950438
61MP0005464_abnormal_platelet_physiology1.32644660
62MP0005387_immune_system_phenotype1.32524615
63MP0001790_abnormal_immune_system1.32524615
64MP0004087_abnormal_muscle_fiber1.32153432
65MP0005083_abnormal_biliary_tract1.31799753
66MP0002722_abnormal_immune_system1.31478026
67MP0000716_abnormal_immune_system1.31353869
68MP0005501_abnormal_skin_physiology1.30565866
69MP0002452_abnormal_antigen_presenting1.28200412
70MP0000013_abnormal_adipose_tissue1.26644893
71MP0004808_abnormal_hematopoietic_stem1.25308051
72MP0002429_abnormal_blood_cell1.25039988
73MP0002723_abnormal_immune_serum1.24391523
74MP0000678_abnormal_parathyroid_gland1.24210758
75MP0001348_abnormal_lacrimal_gland1.22858997
76MP0000689_abnormal_spleen_morphology1.22541714
77MP0005330_cardiomyopathy1.21894809
78MP0003693_abnormal_embryo_hatching1.21710677
79MP0005621_abnormal_cell_physiology1.19879406
80MP0003806_abnormal_nucleotide_metabolis1.19461083
81MP0003077_abnormal_cell_cycle1.19034806
82MP0000604_amyloidosis1.19031331
83MP0005025_abnormal_response_to1.18852410
84MP0003191_abnormal_cellular_cholesterol1.15818963
85MP0002080_prenatal_lethality1.14101577
86MP0003315_abnormal_perineum_morphology1.13379553
87MP0009672_abnormal_birth_weight1.12479148
88MP0003221_abnormal_cardiomyocyte_apopto1.11189308
89MP0005408_hypopigmentation1.10362235
90MP0006036_abnormal_mitochondrial_physio1.10271071
91MP0000358_abnormal_cell_content/1.09590366
92MP0009333_abnormal_splenocyte_physiolog1.07453542
93MP0002735_abnormal_chemical_nociception1.07193358
94MP0003866_abnormal_defecation1.06308147
95MP0000003_abnormal_adipose_tissue1.06127075
96MP0009931_abnormal_skin_appearance1.06126801
97MP0000377_abnormal_hair_follicle1.05202297
98MP0002064_seizures1.05007656
99MP0003137_abnormal_impulse_conducting1.03367171
100MP0004811_abnormal_neuron_physiology1.02880873
101MP0002419_abnormal_innate_immunity1.02659094
102MP0000759_abnormal_skeletal_muscle1.02241195
103MP0010352_gastrointestinal_tract_polyps1.01994894
104MP0003279_aneurysm1.01852770
105MP0005166_decreased_susceptibility_to1.01508407
106MP0002166_altered_tumor_susceptibility1.00855412
107MP0000465_gastrointestinal_hemorrhage1.00099017
108MP0002009_preneoplasia0.98609351
109MP0004233_abnormal_muscle_weight0.98173508
110MP0005171_absent_coat_pigmentation0.96550925
111MP0004270_analgesia0.95927667
112MP0001533_abnormal_skeleton_physiology0.95548087
113MP0005384_cellular_phenotype0.95344082
114MP0001216_abnormal_epidermal_layer0.94763856
115MP0002060_abnormal_skin_morphology0.93734855
116MP0003705_abnormal_hypodermis_morpholog0.93535353
117MP0000537_abnormal_urethra_morphology0.93345926
118MP0002933_joint_inflammation0.92012261
119MP0003453_abnormal_keratinocyte_physiol0.91343817
120MP0010630_abnormal_cardiac_muscle0.90009924
121MP0002970_abnormal_white_adipose0.88432692
122MP0009785_altered_susceptibility_to0.87045073
123MP0001968_abnormal_touch/_nociception0.86884838
124MP0005375_adipose_tissue_phenotype0.86000465
125MP0006035_abnormal_mitochondrial_morpho0.85641511
126MP0000609_abnormal_liver_physiology0.85025205
127MP0010234_abnormal_vibrissa_follicle0.84830303
128MP0003879_abnormal_hair_cell0.84132375
129MP0000371_diluted_coat_color0.83744568
130MP0003123_paternal_imprinting0.82829538
131MP0005220_abnormal_exocrine_pancreas0.82777899
132MP0002249_abnormal_larynx_morphology0.82278812
133MP0005076_abnormal_cell_differentiation0.82050460
134MP0002063_abnormal_learning/memory/cond0.82035205
135MP0004215_abnormal_myocardial_fiber0.81140147
136MP0005584_abnormal_enzyme/coenzyme_acti0.80939121
137MP0002086_abnormal_extraembryonic_tissu0.80797049
138MP0001727_abnormal_embryo_implantation0.80243415
139MP0001845_abnormal_inflammatory_respons0.80096905
140MP0000350_abnormal_cell_proliferation0.78831349
141MP0002234_abnormal_pharynx_morphology0.78548570
142MP0001346_abnormal_lacrimal_gland0.78002296
143MP0000681_abnormal_thyroid_gland0.77939774
144MP0003566_abnormal_cell_adhesion0.77565251
145MP0002736_abnormal_nociception_after0.76288369
146MP0001661_extended_life_span0.75452686
147MP0003045_fibrosis0.75241024
148MP0002106_abnormal_muscle_physiology0.74722242
149MP0010155_abnormal_intestine_physiology0.74560754
150MP0004947_skin_inflammation0.74186714
151MP0000313_abnormal_cell_death0.73001727
152MP0002971_abnormal_brown_adipose0.72757388
153MP0003984_embryonic_growth_retardation0.70479333
154MP0000733_abnormal_muscle_development0.68295961
155MP0005365_abnormal_bile_salt0.67083845
156MP0003136_yellow_coat_color0.67034970
157MP0001697_abnormal_embryo_size0.66064296
158MP0005380_embryogenesis_phenotype0.65402324
159MP0001672_abnormal_embryogenesis/_devel0.65402324
160MP0001666_abnormal_nutrient_absorption0.65198416
161MP0008932_abnormal_embryonic_tissue0.64767607
162MP0000462_abnormal_digestive_system0.64652916

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.44715888
2Cholecystitis (HP:0001082)4.39460727
3Abnormal gallbladder physiology (HP:0012438)4.39460727
4Insomnia (HP:0100785)3.77788402
5Abnormality of the lower motor neuron (HP:0002366)3.67501656
6Exercise-induced myalgia (HP:0003738)3.19431427
7Myopathic facies (HP:0002058)3.12875561
8Ragged-red muscle fibers (HP:0003200)3.03163621
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.01064286
10Elfin facies (HP:0004428)2.97866631
11Reticulocytosis (HP:0001923)2.88844278
12Myoglobinuria (HP:0002913)2.87572111
13Distal lower limb amyotrophy (HP:0008944)2.80106919
14J-shaped sella turcica (HP:0002680)2.75091441
15Growth hormone excess (HP:0000845)2.72354661
16Bundle branch block (HP:0011710)2.65422686
17Deep venous thrombosis (HP:0002625)2.65239621
18Abnormality of the nasal mucosa (HP:0000433)2.64580168
19Limb-girdle muscle atrophy (HP:0003797)2.64238385
20Cellulitis (HP:0100658)2.60217267
21Distal upper limb amyotrophy (HP:0007149)2.56895500
22Upper limb amyotrophy (HP:0009129)2.56895500
23Sudden death (HP:0001699)2.56399151
24Recurrent bronchitis (HP:0002837)2.51800170
25Overriding aorta (HP:0002623)2.50719220
26Cerebral aneurysm (HP:0004944)2.48408601
27Cholelithiasis (HP:0001081)2.43124826
28Difficulty climbing stairs (HP:0003551)2.41754783
29Polycythemia (HP:0001901)2.40374050
30Peripheral hypomyelination (HP:0007182)2.38930558
31Supranuclear gaze palsy (HP:0000605)2.36578780
32Distal lower limb muscle weakness (HP:0009053)2.36075598
33Poikiloderma (HP:0001029)2.35033543
34Gastrointestinal inflammation (HP:0004386)2.34449513
35Seborrheic dermatitis (HP:0001051)2.32231022
36Chronic otitis media (HP:0000389)2.31237054
37Asymmetric septal hypertrophy (HP:0001670)2.31007057
38Verrucae (HP:0200043)2.30864295
39Papilloma (HP:0012740)2.30864295
40Hand muscle atrophy (HP:0009130)2.30551531
41Neoplasm of the heart (HP:0100544)2.29798952
42Foot dorsiflexor weakness (HP:0009027)2.28646382
43Increased variability in muscle fiber diameter (HP:0003557)2.28532052
44Abnormality of skeletal muscle fiber size (HP:0012084)2.25746667
45Hammertoe (HP:0001765)2.24006309
46Ventricular fibrillation (HP:0001663)2.23337255
47Elevated erythrocyte sedimentation rate (HP:0003565)2.23323973
48Increased connective tissue (HP:0009025)2.23234870
49High pitched voice (HP:0001620)2.22470710
50Death in childhood (HP:0003819)2.21788885
51Myokymia (HP:0002411)2.21208523
52Orthostatic hypotension (HP:0001278)2.19281042
53Ankle clonus (HP:0011448)2.18704611
54Abnormality of the left ventricular outflow tract (HP:0011103)2.17996519
55Subaortic stenosis (HP:0001682)2.17996519
56Hypercortisolism (HP:0001578)2.16259840
57Renovascular hypertension (HP:0100817)2.15619813
58Diminished motivation (HP:0000745)2.15451940
59Apathy (HP:0000741)2.14844720
60Rapidly progressive (HP:0003678)2.13642223
61Alacrima (HP:0000522)2.10731995
62Abnormal gallbladder morphology (HP:0012437)2.10393473
63Dysmetric saccades (HP:0000641)2.08990804
64Nasal polyposis (HP:0100582)2.08477624
65Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.06565183
66Pointed chin (HP:0000307)2.05126814
67Abnormality of glycolysis (HP:0004366)2.04397229
68Back pain (HP:0003418)2.03948883
69Gastrointestinal dysmotility (HP:0002579)2.03782484
70Inflammation of the large intestine (HP:0002037)2.01778123
71Abnormality of the foot musculature (HP:0001436)2.01615087
72Achilles tendon contracture (HP:0001771)2.01039558
73Right ventricular cardiomyopathy (HP:0011663)2.00872028
74Hemorrhage of the eye (HP:0011885)1.99728861
75Depression (HP:0000716)1.99524297
76Ventricular tachycardia (HP:0004756)1.99350458
77Frequent falls (HP:0002359)1.94450025
78Chest pain (HP:0100749)1.94214152
79Aneurysm (HP:0002617)1.94035363
80Abnormality of the gallbladder (HP:0005264)1.93696395
81Striae distensae (HP:0001065)1.92491197
82Microvesicular hepatic steatosis (HP:0001414)1.91925477
83Exercise-induced muscle cramps (HP:0003710)1.90903812
84Thoracic kyphosis (HP:0002942)1.90653669
85Abnormal delayed hypersensitivity skin test (HP:0002963)1.90217405
86Hypoventilation (HP:0002791)1.89541830
87Dysostosis multiplex (HP:0000943)1.89540650
88Bowel diverticulosis (HP:0005222)1.89434995
89Termporal pattern (HP:0011008)1.89354827
90Insidious onset (HP:0003587)1.89354827
91Eczematoid dermatitis (HP:0000976)1.89340386
92Visual hallucinations (HP:0002367)1.88512497
93Obstructive sleep apnea (HP:0002870)1.87670688
94Abnormality of endocrine pancreas physiology (HP:0012093)1.86621677
95Abnormality of the pancreatic islet cells (HP:0006476)1.86621677
96Neuronal loss in central nervous system (HP:0002529)1.85641871
97Difficulty running (HP:0009046)1.85584057
98Advanced eruption of teeth (HP:0006288)1.85220961
99Rhabdomyolysis (HP:0003201)1.84435957
100Bladder diverticulum (HP:0000015)1.84221993
101Progressive microcephaly (HP:0000253)1.84062504
102Cerebral palsy (HP:0100021)1.83843548
103Late onset (HP:0003584)1.83826101
104Colitis (HP:0002583)1.83656125
105Progressive muscle weakness (HP:0003323)1.83062012
106Vertebral compression fractures (HP:0002953)1.82644414
107Amyotrophic lateral sclerosis (HP:0007354)1.81905411
108Abnormality of the Achilles tendon (HP:0005109)1.81550144
109Papilledema (HP:0001085)1.81139855
110Insulin resistance (HP:0000855)1.80802222
111Fatigue (HP:0012378)1.80642045
112Flat cornea (HP:0007720)1.80240787
113Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.80187346
114Thrombocytosis (HP:0001894)1.80154449
115Systemic lupus erythematosus (HP:0002725)1.79835470
116Annular pancreas (HP:0001734)1.79433558
117Recurrent viral infections (HP:0004429)1.79060949
118Athetosis (HP:0002305)1.78701130
119Atelectasis (HP:0100750)1.78698769
120Gout (HP:0001997)1.78672556
121Distal sensory impairment (HP:0002936)1.78641637
122Urinary urgency (HP:0000012)1.78244854
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78184837
124Upper limb muscle weakness (HP:0003484)1.78182222
125Global brain atrophy (HP:0002283)1.77919864
126Abnormal neuron morphology (HP:0012757)1.76552292
127Abnormality of the motor neurons (HP:0002450)1.76552292
128Severe short stature (HP:0003510)1.76286994
129Long toe (HP:0010511)1.75877802
130Abnormality of the thoracic spine (HP:0100711)1.75691593
131Flat acetabular roof (HP:0003180)1.75502756
132Lower limb amyotrophy (HP:0007210)1.75348426
133Asymmetry of the thorax (HP:0001555)1.74874704
134Loss of speech (HP:0002371)1.74500631
135Mildly elevated creatine phosphokinase (HP:0008180)1.74470159
136Renal duplication (HP:0000075)1.74388320
137Aortic aneurysm (HP:0004942)1.74099215
138Myotonia (HP:0002486)1.73928595
139Hemiplegia (HP:0002301)1.73730415
140Germ cell neoplasia (HP:0100728)1.73313525
141Precocious puberty (HP:0000826)1.73069384
142Interstitial pulmonary disease (HP:0006530)1.71342223
143Recurrent fungal infections (HP:0002841)1.71127666
144Mucopolysacchariduria (HP:0008155)1.70113931
145Urinary glycosaminoglycan excretion (HP:0003541)1.70113931
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69127661
147Recurrent abscess formation (HP:0002722)1.68788131
148Urticaria (HP:0001025)1.68786011
149Abnormal social behavior (HP:0012433)1.67362111
150Impaired social interactions (HP:0000735)1.67362111
151Abnormality of pain sensation (HP:0010832)1.66921164
152Impaired pain sensation (HP:0007328)1.66921164
153Decreased motor nerve conduction velocity (HP:0003431)1.66754658
154Long palpebral fissure (HP:0000637)1.65868683
155Lymphangioma (HP:0100764)1.65309011
156Deformed sella turcica (HP:0002681)1.64819487
157Stridor (HP:0010307)1.64645433
158Impaired smooth pursuit (HP:0007772)1.64593508
159Easy fatigability (HP:0003388)1.64532594
160Abnormality of polysaccharide metabolism (HP:0011012)1.64530401
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64530401
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64530401
163Flattened epiphyses (HP:0003071)1.64371654
164Diaphragmatic weakness (HP:0009113)1.63824429
165Cardiomegaly (HP:0001640)1.63713799
166Segmental peripheral demyelination/remyelination (HP:0003481)1.62042727
167Prolonged neonatal jaundice (HP:0006579)1.61155669
168Truncus arteriosus (HP:0001660)1.60883556
169Bowel incontinence (HP:0002607)1.60550492
170Cerebral inclusion bodies (HP:0100314)1.60193131
171Ileus (HP:0002595)1.59769967
172Abnormality of aromatic amino acid family metabolism (HP:0004338)1.58215788
173Spinal rigidity (HP:0003306)1.58087401
174EMG: myopathic abnormalities (HP:0003458)1.57900080
175Macroorchidism (HP:0000053)1.57495027
176Cervical subluxation (HP:0003308)1.56866333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.50060744
2TRIB34.31483358
3MAP3K103.68926065
4PKN23.04034136
5ERN12.78449222
6CDK122.72591695
7EEF2K2.59854772
8SMG12.57340827
9MAP4K12.52251092
10PRPF4B2.43018947
11MAP3K92.35899020
12TESK22.27662409
13PRKD32.05605181
14NME21.93124391
15TTN1.68907891
16FGFR41.64906902
17EPHA21.54611077
18TAOK11.42930066
19NEK11.42255254
20EIF2AK11.41366290
21ICK1.40160311
22ZAP701.38742580
23PHKG11.37209481
24PHKG21.37209481
25SIK21.33916231
26MTOR1.31213818
27IRAK31.30160200
28KDR1.29313581
29TESK11.26560735
30NTRK31.25760277
31MARK31.21539103
32GRK61.20356320
33DAPK11.19174048
34SIK31.18888009
35STK381.16756157
36MAP3K71.16321333
37KSR21.15268586
38PDGFRA1.12861705
39LIMK11.10728018
40TYK21.08795443
41PTK61.08396031
42RIPK11.07285465
43EPHA41.07090135
44CAMKK11.05003530
45DAPK21.04419476
46MST1R1.03895513
47FES1.01041826
48TYRO30.99585537
49LRRK20.98171470
50BTK0.98125152
51BLK0.97572170
52SYK0.95031319
53MAP3K20.94735691
54PAK60.93201281
55LMTK20.91798952
56ALK0.90874962
57RET0.90368128
58BMX0.88504361
59NTRK10.87780051
60PBK0.87459211
61DAPK30.87371253
62RPS6KB20.86498102
63PTK20.86275372
64NEK60.85652499
65TSSK60.84836271
66TBK10.83565584
67TLK10.82731014
68MAP3K40.81176096
69TNK20.80782006
70DMPK0.80347722
71MAPKAPK30.80121385
72MAP2K40.79823962
73PRKCH0.77237936
74CSK0.76982831
75PRKG20.76370960
76NME10.76334456
77DYRK1B0.75898483
78MAP2K20.75564840
79MAP3K60.74791454
80STK100.74751341
81CDK70.72322366
82MAP3K110.72306597
83HCK0.72160735
84MAP2K70.71379044
85ILK0.70243949
86BRSK10.69554890
87EPHB10.69494595
88BCKDK0.68789155
89MAP2K30.68737921
90FLT30.67928478
91TAOK20.67655770
92HIPK20.66916879
93MINK10.65653615
94MARK20.65273943
95JAK30.65205017
96MAP3K130.64729126
97VRK20.64287099
98KIT0.63777021
99MAP3K30.62954360
100NTRK20.62167641
101PDK30.61926591
102PDK40.61926591
103MAP3K80.61743160
104CDC42BPA0.61047103
105JAK10.60615269
106PRKD10.59746384
107SCYL20.58267260
108PRKD20.57769582
109TGFBR10.57550686
110NEK20.57412723
111ARAF0.57096323
112MAP2K60.56512529
113ITK0.56498052
114MAP3K10.55643827
115JAK20.53153922
116CDK11A0.52508526
117CAMKK20.51948664
118PAK40.51299849
119CAMK10.51143362
120PDPK10.51021817
121KSR10.50967023
122PDK10.48889148
123CDK140.48700213
124MAPK110.48085998
125MARK10.47946500
126CDK60.47945469
127AKT20.47810459
128FER0.47661145
129MAPK120.47007411
130CDK40.46581217
131CDK90.46397206
132RPS6KA20.44709523
133TNIK0.43237566
134PINK10.42626624
135MAPK100.42339071
136SIK10.42300467
137CDK150.41446873
138CDK50.41040267
139RIPK40.39728971
140CDK180.38210875
141LCK0.37509034
142CHEK10.36979265
143CCNB10.34187480
144PRKAA10.32986825
145PIM20.32841777
146RAF10.31986726
147AURKA0.31828459

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.53758998
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.43962301
3Fructose and mannose metabolism_Homo sapiens_hsa000512.41717650
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22239729
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07523217
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04537548
7B cell receptor signaling pathway_Homo sapiens_hsa046621.97729394
8VEGF signaling pathway_Homo sapiens_hsa043701.92092860
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.89954315
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89005825
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88174816
12Primary immunodeficiency_Homo sapiens_hsa053401.86455470
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73691664
14Thyroid cancer_Homo sapiens_hsa052161.57912711
15Neurotrophin signaling pathway_Homo sapiens_hsa047221.57892284
16T cell receptor signaling pathway_Homo sapiens_hsa046601.51824382
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.48700875
18Vibrio cholerae infection_Homo sapiens_hsa051101.48374623
19Arginine biosynthesis_Homo sapiens_hsa002201.47204331
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46115249
21Fatty acid metabolism_Homo sapiens_hsa012121.44331562
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42276920
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40453234
24Synaptic vesicle cycle_Homo sapiens_hsa047211.37463882
25Chronic myeloid leukemia_Homo sapiens_hsa052201.35376126
26Endometrial cancer_Homo sapiens_hsa052131.33684086
27Olfactory transduction_Homo sapiens_hsa047401.31311138
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28764196
29Type II diabetes mellitus_Homo sapiens_hsa049301.28571559
30mTOR signaling pathway_Homo sapiens_hsa041501.27351526
31Acute myeloid leukemia_Homo sapiens_hsa052211.26412594
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24370168
33Carbon metabolism_Homo sapiens_hsa012001.21832793
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21640797
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20879429
36Osteoclast differentiation_Homo sapiens_hsa043801.20445527
37N-Glycan biosynthesis_Homo sapiens_hsa005101.19920129
38Insulin signaling pathway_Homo sapiens_hsa049101.18849057
39Shigellosis_Homo sapiens_hsa051311.17963394
40Glioma_Homo sapiens_hsa052141.17942293
41Circadian entrainment_Homo sapiens_hsa047131.17413185
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16363269
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15833778
44Viral myocarditis_Homo sapiens_hsa054161.15151953
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.13993604
46Insulin resistance_Homo sapiens_hsa049311.12311095
47Sulfur relay system_Homo sapiens_hsa041221.11869477
48Dilated cardiomyopathy_Homo sapiens_hsa054141.10815143
49Long-term potentiation_Homo sapiens_hsa047201.10794892
50Phenylalanine metabolism_Homo sapiens_hsa003601.10755518
51Fatty acid elongation_Homo sapiens_hsa000621.10728831
52Endocytosis_Homo sapiens_hsa041441.10151924
53Biosynthesis of amino acids_Homo sapiens_hsa012301.09387645
54Leishmaniasis_Homo sapiens_hsa051401.08977890
55Pentose phosphate pathway_Homo sapiens_hsa000301.06671237
56Non-small cell lung cancer_Homo sapiens_hsa052231.05756488
57Prion diseases_Homo sapiens_hsa050201.02283515
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.01435010
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98687761
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.98192942
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98113902
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97391359
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96695957
64Notch signaling pathway_Homo sapiens_hsa043300.96356758
65Oxytocin signaling pathway_Homo sapiens_hsa049210.93703651
66Renin-angiotensin system_Homo sapiens_hsa046140.93370089
67Colorectal cancer_Homo sapiens_hsa052100.92026300
68Arginine and proline metabolism_Homo sapiens_hsa003300.90323780
69Inositol phosphate metabolism_Homo sapiens_hsa005620.88681455
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88122760
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.87309144
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87156136
73Pancreatic cancer_Homo sapiens_hsa052120.87120877
74Platelet activation_Homo sapiens_hsa046110.86616966
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86247748
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.85836654
77Chemokine signaling pathway_Homo sapiens_hsa040620.85562469
78Bladder cancer_Homo sapiens_hsa052190.85030523
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84667226
80Dopaminergic synapse_Homo sapiens_hsa047280.83711859
81Insulin secretion_Homo sapiens_hsa049110.83489341
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83230903
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82993276
84Estrogen signaling pathway_Homo sapiens_hsa049150.82303990
85ErbB signaling pathway_Homo sapiens_hsa040120.81714138
86Lysosome_Homo sapiens_hsa041420.79476001
87Glucagon signaling pathway_Homo sapiens_hsa049220.78946115
88Gastric acid secretion_Homo sapiens_hsa049710.78838628
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77795061
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76188776
91HIF-1 signaling pathway_Homo sapiens_hsa040660.75227836
92Base excision repair_Homo sapiens_hsa034100.74668258
93Antigen processing and presentation_Homo sapiens_hsa046120.74134077
94Tuberculosis_Homo sapiens_hsa051520.74120678
95Adherens junction_Homo sapiens_hsa045200.73787061
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73252869
97Gap junction_Homo sapiens_hsa045400.72469344
98Lysine degradation_Homo sapiens_hsa003100.72204623
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71755884
100Renal cell carcinoma_Homo sapiens_hsa052110.69912489
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69545430
102Morphine addiction_Homo sapiens_hsa050320.68562467
103Apoptosis_Homo sapiens_hsa042100.68354372
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66770509
105GnRH signaling pathway_Homo sapiens_hsa049120.66588542
106AMPK signaling pathway_Homo sapiens_hsa041520.66308823
107Hepatitis C_Homo sapiens_hsa051600.66301350
108Toxoplasmosis_Homo sapiens_hsa051450.65538257
109Measles_Homo sapiens_hsa051620.65266366
110Other glycan degradation_Homo sapiens_hsa005110.65047139
111Cholinergic synapse_Homo sapiens_hsa047250.64642336
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64541338
113mRNA surveillance pathway_Homo sapiens_hsa030150.64178155
114Hepatitis B_Homo sapiens_hsa051610.63868680
115Spliceosome_Homo sapiens_hsa030400.62698794
116HTLV-I infection_Homo sapiens_hsa051660.62286029
117Choline metabolism in cancer_Homo sapiens_hsa052310.61563717
118Prolactin signaling pathway_Homo sapiens_hsa049170.61017133
119Salmonella infection_Homo sapiens_hsa051320.60560211
120Fatty acid biosynthesis_Homo sapiens_hsa000610.58805990
121Bile secretion_Homo sapiens_hsa049760.58062541
122DNA replication_Homo sapiens_hsa030300.57842658
123Amphetamine addiction_Homo sapiens_hsa050310.57387770
124Calcium signaling pathway_Homo sapiens_hsa040200.57094665
125Salivary secretion_Homo sapiens_hsa049700.56475996
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55286153
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54516208
128Pyruvate metabolism_Homo sapiens_hsa006200.54485547
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.54236361
130Prostate cancer_Homo sapiens_hsa052150.53616183
131Glutamatergic synapse_Homo sapiens_hsa047240.52349027
132Galactose metabolism_Homo sapiens_hsa000520.52331125
133Steroid biosynthesis_Homo sapiens_hsa001000.48557777
134Starch and sucrose metabolism_Homo sapiens_hsa005000.46870831
135Complement and coagulation cascades_Homo sapiens_hsa046100.45431266
136Tyrosine metabolism_Homo sapiens_hsa003500.45365565
137Glutathione metabolism_Homo sapiens_hsa004800.45051759
138Fatty acid degradation_Homo sapiens_hsa000710.43827436
139PPAR signaling pathway_Homo sapiens_hsa033200.42396933
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41542068
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41472494
142Vitamin B6 metabolism_Homo sapiens_hsa007500.39227885
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.37511234

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