VPS53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with sequence similarity to the yeast Vps53p protein. Vps53p is involved in retrograde vesicle trafficking in late Golgi. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.32090630
2synaptic vesicle exocytosis (GO:0016079)5.19554203
3synaptic vesicle maturation (GO:0016188)5.13797276
4behavioral response to nicotine (GO:0035095)4.80478665
5regulation of synaptic vesicle exocytosis (GO:2000300)4.74302937
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.63870298
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.60964410
8regulation of synaptic vesicle transport (GO:1902803)4.58191526
9glutamate secretion (GO:0014047)4.36523691
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29337769
11protein localization to synapse (GO:0035418)4.09855387
12ATP hydrolysis coupled proton transport (GO:0015991)3.96508852
13energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.96508852
14transferrin transport (GO:0033572)3.96129207
15locomotory exploration behavior (GO:0035641)3.83286642
16neurotransmitter secretion (GO:0007269)3.78629187
17synaptic transmission, glutamatergic (GO:0035249)3.73201255
18vocalization behavior (GO:0071625)3.67617690
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.67058968
20trivalent inorganic cation transport (GO:0072512)3.66240226
21ferric iron transport (GO:0015682)3.66240226
22postsynaptic membrane organization (GO:0001941)3.61193719
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.53749963
24regulation of glutamate receptor signaling pathway (GO:1900449)3.50553569
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.48072936
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.44211304
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43622324
28startle response (GO:0001964)3.42546312
29synaptic vesicle endocytosis (GO:0048488)3.42245815
30cellular response to ATP (GO:0071318)3.35470291
31neuron-neuron synaptic transmission (GO:0007270)3.34149666
32regulation of synapse structural plasticity (GO:0051823)3.31811369
33phagosome maturation (GO:0090382)3.20188727
34regulation of neuronal synaptic plasticity (GO:0048168)3.19884836
35gamma-aminobutyric acid transport (GO:0015812)3.17171352
36negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16995278
37response to pheromone (GO:0019236)3.16183296
38dendritic spine morphogenesis (GO:0060997)3.16126391
39negative regulation of microtubule polymerization (GO:0031115)3.15069032
40urinary tract smooth muscle contraction (GO:0014848)3.14197214
41fucose catabolic process (GO:0019317)3.13948087
42L-fucose metabolic process (GO:0042354)3.13948087
43L-fucose catabolic process (GO:0042355)3.13948087
44exploration behavior (GO:0035640)3.13171000
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12710783
46vesicle docking involved in exocytosis (GO:0006904)3.12003589
47regulation of neurotransmitter secretion (GO:0046928)3.08872078
48neuronal action potential (GO:0019228)3.07081039
49regulation of voltage-gated calcium channel activity (GO:1901385)3.05621557
50regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05502735
51positive regulation of membrane potential (GO:0045838)3.05353831
52detection of light stimulus involved in sensory perception (GO:0050962)3.04279859
53detection of light stimulus involved in visual perception (GO:0050908)3.04279859
54establishment of synaptic vesicle localization (GO:0097480)3.02815869
55synaptic vesicle transport (GO:0048489)3.02815869
56neurotransmitter transport (GO:0006836)3.02315416
57neuromuscular synaptic transmission (GO:0007274)3.01607095
58primary amino compound metabolic process (GO:1901160)3.01497584
59neurotransmitter-gated ion channel clustering (GO:0072578)2.98982390
60cAMP catabolic process (GO:0006198)2.96219606
61clathrin coat assembly (GO:0048268)2.95977597
62serotonin metabolic process (GO:0042428)2.94790368
63presynaptic membrane assembly (GO:0097105)2.93599434
64glutamate receptor signaling pathway (GO:0007215)2.92550703
65negative regulation of dendrite morphogenesis (GO:0050774)2.90255258
66regulation of action potential (GO:0098900)2.89415386
67activation of protein kinase A activity (GO:0034199)2.88918313
68cyclic nucleotide catabolic process (GO:0009214)2.87911204
69membrane hyperpolarization (GO:0060081)2.87151617
70transmission of nerve impulse (GO:0019226)2.87039932
71regulation of neurotransmitter levels (GO:0001505)2.84335839
72vesicle docking (GO:0048278)2.82031348
73membrane depolarization (GO:0051899)2.81917499
74positive regulation of synapse maturation (GO:0090129)2.81616881
75presynaptic membrane organization (GO:0097090)2.80757582
76behavioral fear response (GO:0001662)2.80692503
77behavioral defense response (GO:0002209)2.80692503
78innervation (GO:0060384)2.80039169
79auditory behavior (GO:0031223)2.78808871
80regulation of neurotransmitter transport (GO:0051588)2.78583438
81regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78565239
82negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74891288
83regulation of vesicle fusion (GO:0031338)2.74873315
84regulation of neurotransmitter uptake (GO:0051580)2.74494222
85protein polyglutamylation (GO:0018095)2.74420012
86positive regulation of exocytosis (GO:0045921)2.74160991
87NADH metabolic process (GO:0006734)2.73679443
88ribonucleoprotein complex disassembly (GO:0032988)2.71933466
89cerebellar Purkinje cell differentiation (GO:0021702)2.71895213
90proline transport (GO:0015824)2.71440522
91regulation of synaptic plasticity (GO:0048167)2.71394587
92alanine transport (GO:0032328)2.71045192
93negative regulation of dendrite development (GO:2000171)2.70756427
94establishment of protein localization to Golgi (GO:0072600)2.70530255
95peristalsis (GO:0030432)2.70241985
96long-term synaptic potentiation (GO:0060291)2.69389891
97neuron cell-cell adhesion (GO:0007158)2.69133843
98regulation of exocytosis (GO:0017157)2.68852244
99chemosensory behavior (GO:0007635)2.67565522
100regulation of respiratory system process (GO:0044065)2.67538756
101positive regulation of neurotransmitter transport (GO:0051590)2.66582614
102COPI coating of Golgi vesicle (GO:0048205)2.65847044
103Golgi transport vesicle coating (GO:0048200)2.65847044
104regulation of amyloid precursor protein catabolic process (GO:1902991)2.63016289
105central nervous system myelination (GO:0022010)2.62837559
106axon ensheathment in central nervous system (GO:0032291)2.62837559
107regulation of postsynaptic membrane potential (GO:0060078)2.62342753
108fear response (GO:0042596)2.62207797
109glycosphingolipid biosynthetic process (GO:0006688)2.59367449
110regulation of hippo signaling (GO:0035330)2.58983164
111negative regulation of Rho protein signal transduction (GO:0035024)2.58812082
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58289484
113dendrite morphogenesis (GO:0048813)2.57399071
114neuronal action potential propagation (GO:0019227)2.56652535
115regulation of calcium ion-dependent exocytosis (GO:0017158)2.55932428
116behavioral response to ethanol (GO:0048149)2.55609479
117righting reflex (GO:0060013)2.55344745
118sulfation (GO:0051923)2.54648414
119establishment of vesicle localization (GO:0051650)2.54160643
120adult walking behavior (GO:0007628)2.53377129
121regulation of respiratory gaseous exchange (GO:0043576)2.52770130
122DNA deamination (GO:0045006)2.52217310
123indolalkylamine metabolic process (GO:0006586)2.50526798
124synapse assembly (GO:0007416)2.50175308
125protein K11-linked deubiquitination (GO:0035871)2.49403085
126positive regulation of CREB transcription factor activity (GO:0032793)2.49046176
127cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.48932138
128positive regulation of fatty acid oxidation (GO:0046321)2.48314520
129negative regulation of synaptic transmission, GABAergic (GO:0032229)2.48190145
130axon cargo transport (GO:0008088)2.47981176
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47425933
132positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.46908407
133negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.46763827
134negative regulation of translation, ncRNA-mediated (GO:0040033)2.46763827
135regulation of translation, ncRNA-mediated (GO:0045974)2.46763827
136synaptic transmission (GO:0007268)2.46512809
137regulation of sodium ion transmembrane transporter activity (GO:2000649)2.46311308
138positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45666388
139regulation of synaptic transmission, dopaminergic (GO:0032225)2.45366073
140calcium ion-dependent exocytosis (GO:0017156)2.44644166
141behavioral response to cocaine (GO:0048148)2.44333355
142kynurenine metabolic process (GO:0070189)2.42698981
143indole-containing compound metabolic process (GO:0042430)2.42506220
144gamma-aminobutyric acid signaling pathway (GO:0007214)2.42463259
145action potential (GO:0001508)2.40238067
146regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.40148037
147regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.40148037
148neuron maturation (GO:0042551)2.39407203
149central nervous system neuron axonogenesis (GO:0021955)2.39364223
150positive regulation of neurotransmitter secretion (GO:0001956)2.38454271
151tryptophan catabolic process (GO:0006569)2.37372945
152indole-containing compound catabolic process (GO:0042436)2.37372945
153indolalkylamine catabolic process (GO:0046218)2.37372945
154sodium ion export (GO:0071436)2.36903565
155response to histamine (GO:0034776)2.36307536
156negative regulation of mast cell activation (GO:0033004)2.35905736
157spinal cord development (GO:0021510)2.35808026
158regulation of synaptic transmission (GO:0050804)2.35160064
159regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.35031701
1603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.34339474
161purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.34339474
162regulation of synaptic transmission, glutamatergic (GO:0051966)2.33958895
163nucleobase catabolic process (GO:0046113)2.33639403
164membrane depolarization during action potential (GO:0086010)2.33353523
165positive regulation of synaptic transmission (GO:0050806)2.32620487
166pyrimidine nucleobase catabolic process (GO:0006208)2.32226216
167regulation of oxidative phosphorylation (GO:0002082)2.31705081
168negative regulation of cation channel activity (GO:2001258)2.31109077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.17592677
2GBX2_23144817_ChIP-Seq_PC3_Human3.81896296
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.73574092
4REST_21632747_ChIP-Seq_MESCs_Mouse2.94788995
5DROSHA_22980978_ChIP-Seq_HELA_Human2.86376514
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.64608231
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.56893748
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.53690763
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43155400
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33799250
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.29860276
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29216585
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23268092
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20966502
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19358205
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18935322
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10013666
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.09810724
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01060023
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92894707
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91503147
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82804611
23TAF15_26573619_Chip-Seq_HEK293_Human1.82336385
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.77228303
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76328043
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76004454
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74365488
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70385089
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.68285403
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63602813
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60862311
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60854682
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60429143
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57205125
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57205125
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54556887
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54107607
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.50045096
39SMAD4_21799915_ChIP-Seq_A2780_Human1.48361350
40VDR_22108803_ChIP-Seq_LS180_Human1.48027786
41IGF1R_20145208_ChIP-Seq_DFB_Human1.46401218
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46294712
43TP53_16413492_ChIP-PET_HCT116_Human1.42954655
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41760605
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41760605
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40386339
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40353741
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.39278680
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37389689
50AHR_22903824_ChIP-Seq_MCF-7_Human1.37309015
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35119583
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33540965
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33276333
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.29454238
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.28687234
56P300_19829295_ChIP-Seq_ESCs_Human1.28344121
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.27592861
58AR_25329375_ChIP-Seq_VCAP_Human1.27384087
59FUS_26573619_Chip-Seq_HEK293_Human1.26463023
60BCAT_22108803_ChIP-Seq_LS180_Human1.24997081
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23532032
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21860477
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.21641921
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21492385
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18918512
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17951623
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16183927
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15720896
69RNF2_27304074_Chip-Seq_NSC_Mouse1.15207404
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15082206
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14365743
72RUNX2_22187159_ChIP-Seq_PCA_Human1.14043611
73* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13696497
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09597359
75EWS_26573619_Chip-Seq_HEK293_Human1.09297075
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.08738025
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08561790
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08230830
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08120830
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.07302522
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06698740
82* FLI1_21867929_ChIP-Seq_TH2_Mouse1.06052075
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04706135
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.03808091
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03653932
86* AR_19668381_ChIP-Seq_PC3_Human1.00628554
87* KDM2B_26808549_Chip-Seq_REH_Human1.00614519
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00579767
89CBP_20019798_ChIP-Seq_JUKART_Human1.00579767
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00349221
91HTT_18923047_ChIP-ChIP_STHdh_Human1.00247667
92SMAD4_21741376_ChIP-Seq_EPCs_Human0.99660787
93JUN_21703547_ChIP-Seq_K562_Human0.99491191
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98725862
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98243135
96AR_21572438_ChIP-Seq_LNCaP_Human0.97914292
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.97410920
98RXR_22108803_ChIP-Seq_LS180_Human0.97338957
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97222324
100STAT3_23295773_ChIP-Seq_U87_Human0.97109893
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95901055
102TP53_22573176_ChIP-Seq_HFKS_Human0.95759828
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95548889
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95496183
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95441902
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94651429
107WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94333633
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94132977
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93504529
110* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93382160
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.92526721
112SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.92345906
113SPI1_23127762_ChIP-Seq_K562_Human0.91136084
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90075058
115TCF4_23295773_ChIP-Seq_U87_Human0.89048494
116THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88887780
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.88865677
118NCOR_22424771_ChIP-Seq_293T_Human0.88055999
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85519719
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85356618
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84106317
122NANOG_19829295_ChIP-Seq_ESCs_Human0.82768359
123SOX2_19829295_ChIP-Seq_ESCs_Human0.82768359
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.82704027
125TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82356055
126* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82142592
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81970434
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81042640
129ZNF274_21170338_ChIP-Seq_K562_Hela0.80871602
130ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.80535309
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79482544
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78994790
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77539112
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76250346
135* SMAD4_21741376_ChIP-Seq_HESCs_Human0.75857480
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.75821655
137ER_23166858_ChIP-Seq_MCF-7_Human0.75332290
138POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75230304
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.73548449
140EGR1_19032775_ChIP-ChIP_M12_Human0.73117060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.40863728
2MP0003183_abnormal_peptide_metabolism3.28585554
3MP0003635_abnormal_synaptic_transmissio3.16936821
4MP0001968_abnormal_touch/_nociception3.14393084
5MP0002735_abnormal_chemical_nociception3.04702767
6MP0002736_abnormal_nociception_after2.93605668
7MP0009745_abnormal_behavioral_response2.79140039
8MP0004270_analgesia2.77026051
9MP0002063_abnormal_learning/memory/cond2.73606405
10MP0002064_seizures2.67905990
11MP0005174_abnormal_tail_pigmentation2.62153463
12MP0002734_abnormal_mechanical_nocicepti2.60832461
13MP0003880_abnormal_central_pattern2.46029403
14MP0003172_abnormal_lysosome_physiology2.40507738
15MP0009046_muscle_twitch2.33267329
16MP0001986_abnormal_taste_sensitivity2.25792790
17MP0002272_abnormal_nervous_system2.22974191
18MP0002733_abnormal_thermal_nociception2.19167994
19MP0002572_abnormal_emotion/affect_behav2.18934867
20MP0010386_abnormal_urinary_bladder2.07543479
21MP0001970_abnormal_pain_threshold2.06434015
22MP0005171_absent_coat_pigmentation1.96802376
23MP0000015_abnormal_ear_pigmentation1.91346072
24MP0003136_yellow_coat_color1.90868613
25MP0001501_abnormal_sleep_pattern1.85289688
26MP0002067_abnormal_sensory_capabilities1.78632189
27MP0009780_abnormal_chondrocyte_physiolo1.71631313
28MP0003879_abnormal_hair_cell1.69501666
29MP0003329_amyloid_beta_deposits1.69347119
30MP0001485_abnormal_pinna_reflex1.69222101
31MP0002909_abnormal_adrenal_gland1.68762618
32MP0002876_abnormal_thyroid_physiology1.68522809
33MP0001440_abnormal_grooming_behavior1.61623332
34MP0004811_abnormal_neuron_physiology1.59885327
35MP0000604_amyloidosis1.56888782
36MP0004142_abnormal_muscle_tone1.54185664
37MP0002102_abnormal_ear_morphology1.54128971
38MP0003195_calcinosis1.54038267
39MP0008569_lethality_at_weaning1.53857810
40MP0001486_abnormal_startle_reflex1.48386981
41MP0000569_abnormal_digit_pigmentation1.48138275
42MP0002653_abnormal_ependyma_morphology1.47784107
43MP0004130_abnormal_muscle_cell1.47006988
44MP0002557_abnormal_social/conspecific_i1.46140415
45MP0006276_abnormal_autonomic_nervous1.45782612
46MP0005423_abnormal_somatic_nervous1.44960345
47MP0002184_abnormal_innervation1.44331618
48MP0005360_urolithiasis1.40391670
49MP0005386_behavior/neurological_phenoty1.39553569
50MP0004924_abnormal_behavior1.39553569
51MP0005551_abnormal_eye_electrophysiolog1.32982836
52MP0002928_abnormal_bile_duct1.32066081
53MP0004742_abnormal_vestibular_system1.31694650
54MP0003646_muscle_fatigue1.31633887
55MP0000631_abnormal_neuroendocrine_gland1.27400419
56MP0005645_abnormal_hypothalamus_physiol1.26712455
57MP0005058_abnormal_lysosome_morphology1.25871261
58MP0005365_abnormal_bile_salt1.25820889
59MP0002229_neurodegeneration1.24376866
60MP0003122_maternal_imprinting1.24027733
61MP0001502_abnormal_circadian_rhythm1.22733875
62MP0004858_abnormal_nervous_system1.22682422
63MP0002139_abnormal_hepatobiliary_system1.22680231
64MP0006072_abnormal_retinal_apoptosis1.22616382
65MP0000427_abnormal_hair_cycle1.21428015
66MP0008961_abnormal_basal_metabolism1.20429701
67MP0008872_abnormal_physiological_respon1.17840199
68MP0003283_abnormal_digestive_organ1.17813467
69MP0000372_irregular_coat_pigmentation1.16780248
70MP0002822_catalepsy1.14850803
71MP0001529_abnormal_vocalization1.14103213
72MP0003011_delayed_dark_adaptation1.13691781
73MP0002066_abnormal_motor_capabilities/c1.12126573
74MP0001984_abnormal_olfaction1.11488435
75MP0004133_heterotaxia1.11429642
76MP0002095_abnormal_skin_pigmentation1.11177292
77MP0002090_abnormal_vision1.08609030
78MP0001963_abnormal_hearing_physiology1.06272643
79MP0010329_abnormal_lipoprotein_level1.05519531
80MP0003868_abnormal_feces_composition1.05381935
81MP0005310_abnormal_salivary_gland1.05056559
82MP0005085_abnormal_gallbladder_physiolo1.05046220
83MP0000955_abnormal_spinal_cord1.05026044
84MP0002882_abnormal_neuron_morphology1.04946020
85MP0008874_decreased_physiological_sensi1.04100462
86MP0001666_abnormal_nutrient_absorption1.03152012
87MP0002069_abnormal_eating/drinking_beha1.02471655
88MP0004510_myositis1.00333587
89MP0003633_abnormal_nervous_system0.99791404
90MP0003787_abnormal_imprinting0.97953588
91MP0005409_darkened_coat_color0.97924187
92MP0004381_abnormal_hair_follicle0.96210623
93MP0000681_abnormal_thyroid_gland0.90790008
94MP0009840_abnormal_foam_cell0.90531468
95MP0000013_abnormal_adipose_tissue0.90476788
96MP0002752_abnormal_somatic_nervous0.90345879
97MP0009697_abnormal_copulation0.89013197
98MP0004885_abnormal_endolymph0.87614655
99MP0008875_abnormal_xenobiotic_pharmacok0.86378715
100MP0005646_abnormal_pituitary_gland0.85687012
101MP0005535_abnormal_body_temperature0.85255750
102MP0001905_abnormal_dopamine_level0.84414616
103MP0000538_abnormal_urinary_bladder0.83188318
104MP0005448_abnormal_energy_balance0.81794267
105MP0001188_hyperpigmentation0.81680933
106MP0003631_nervous_system_phenotype0.81053240
107MP0002152_abnormal_brain_morphology0.80999942
108MP0000026_abnormal_inner_ear0.80022099
109MP0002078_abnormal_glucose_homeostasis0.79943546
110MP0003632_abnormal_nervous_system0.79201491
111MP0000371_diluted_coat_color0.78852142
112MP0002160_abnormal_reproductive_system0.78840958
113MP0000383_abnormal_hair_follicle0.78374784
114MP0005670_abnormal_white_adipose0.77324762
115MP0004019_abnormal_vitamin_homeostasis0.76365692
116MP0001177_atelectasis0.76247999
117MP0004043_abnormal_pH_regulation0.75685922
118MP0000920_abnormal_myelination0.74936090
119MP0001765_abnormal_ion_homeostasis0.74151896
120MP0003075_altered_response_to0.72866189
121MP0005083_abnormal_biliary_tract0.72526629
122MP0002638_abnormal_pupillary_reflex0.72428782
123MP0005195_abnormal_posterior_eye0.71489448
124MP0003866_abnormal_defecation0.71446440
125MP0000778_abnormal_nervous_system0.71378899
126MP0005377_hearing/vestibular/ear_phenot0.71345873
127MP0003878_abnormal_ear_physiology0.71345873
128MP0005584_abnormal_enzyme/coenzyme_acti0.70791801
129MP0001756_abnormal_urination0.70460970
130MP0002837_dystrophic_cardiac_calcinosis0.69015692
131MP0003436_decreased_susceptibility_to0.68989009
132MP0008877_abnormal_DNA_methylation0.67662185
133MP0003191_abnormal_cellular_cholesterol0.66724509
134MP0005253_abnormal_eye_physiology0.66454607
135MP0003045_fibrosis0.63527284
136MP0002751_abnormal_autonomic_nervous0.62803586

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.87316985
2Myokymia (HP:0002411)4.71829719
3Genetic anticipation (HP:0003743)4.65880619
4Visual hallucinations (HP:0002367)4.23008554
5Pancreatic cysts (HP:0001737)3.47242990
6Epileptic encephalopathy (HP:0200134)3.44678756
7Nephronophthisis (HP:0000090)3.25670545
8Focal seizures (HP:0007359)3.25162791
9Molar tooth sign on MRI (HP:0002419)3.23419146
10Abnormality of midbrain morphology (HP:0002418)3.23419146
11Pancreatic fibrosis (HP:0100732)3.20337583
12Neuroendocrine neoplasm (HP:0100634)3.18856887
13Pheochromocytoma (HP:0002666)3.06971310
14Absence seizures (HP:0002121)3.02369905
15Protruding tongue (HP:0010808)2.95234529
16Congenital sensorineural hearing impairment (HP:0008527)2.94003162
17Absent speech (HP:0001344)2.92875637
18Dialeptic seizures (HP:0011146)2.90692907
19Attenuation of retinal blood vessels (HP:0007843)2.90172666
20Febrile seizures (HP:0002373)2.87189950
21True hermaphroditism (HP:0010459)2.84713892
22Abnormality of the renal medulla (HP:0100957)2.82608064
23Supranuclear gaze palsy (HP:0000605)2.77328402
24Abnormality of binocular vision (HP:0011514)2.77031243
25Diplopia (HP:0000651)2.77031243
26Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.71977018
27Short 1st metacarpal (HP:0010034)2.71977018
28Failure to thrive in infancy (HP:0001531)2.70157527
29Poor eye contact (HP:0000817)2.69955704
30Hemiparesis (HP:0001269)2.69910210
31Clumsiness (HP:0002312)2.69433184
32Chronic hepatic failure (HP:0100626)2.67177094
33Tubular atrophy (HP:0000092)2.66442193
34Abnormality of the renal cortex (HP:0011035)2.65452291
35Atonic seizures (HP:0010819)2.64631379
36Vacuolated lymphocytes (HP:0001922)2.63695234
37Ankle clonus (HP:0011448)2.61378576
38Generalized tonic-clonic seizures (HP:0002069)2.60887347
39Progressive cerebellar ataxia (HP:0002073)2.60321006
40Agitation (HP:0000713)2.60248337
41Epileptiform EEG discharges (HP:0011182)2.58725901
42Abnormal social behavior (HP:0012433)2.58168232
43Impaired social interactions (HP:0000735)2.58168232
44Inability to walk (HP:0002540)2.56235117
45Polyphagia (HP:0002591)2.51173308
46Type II lissencephaly (HP:0007260)2.49627564
47Anxiety (HP:0000739)2.49421043
48EEG with generalized epileptiform discharges (HP:0011198)2.49212573
49Hemiplegia (HP:0002301)2.47868376
50Abnormal eating behavior (HP:0100738)2.46159643
51Congenital stationary night blindness (HP:0007642)2.45221562
52Hypsarrhythmia (HP:0002521)2.44883526
53Poor suck (HP:0002033)2.40986989
54Cystic liver disease (HP:0006706)2.38074142
55Oligomenorrhea (HP:0000876)2.36747809
56Hyperventilation (HP:0002883)2.34452599
57Abnormal drinking behavior (HP:0030082)2.34273613
58Polydipsia (HP:0001959)2.34273613
59Focal dystonia (HP:0004373)2.33678129
60Abnormality of the nasal septum (HP:0000419)2.33460022
61Bony spicule pigmentary retinopathy (HP:0007737)2.33002500
62Fetal akinesia sequence (HP:0001989)2.31748453
63Abnormality of the 1st metacarpal (HP:0010009)2.29717671
64Increased cerebral lipofuscin (HP:0011813)2.27478358
65Abnormal hair whorl (HP:0010721)2.23841387
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.22778431
67Abnormality of glycolipid metabolism (HP:0010969)2.22778431
68Abnormality of liposaccharide metabolism (HP:0010968)2.22778431
69Medial flaring of the eyebrow (HP:0010747)2.22650364
70Severe visual impairment (HP:0001141)2.22402413
71Torticollis (HP:0000473)2.21911863
72Psychosis (HP:0000709)2.21085745
73Papilledema (HP:0001085)2.20958636
74Urinary urgency (HP:0000012)2.20813452
75Widely spaced teeth (HP:0000687)2.19543194
76Progressive inability to walk (HP:0002505)2.17774940
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.17354329
78Spastic gait (HP:0002064)2.16880477
79Dysostosis multiplex (HP:0000943)2.16517982
80Decreased central vision (HP:0007663)2.14030738
81Craniofacial dystonia (HP:0012179)2.13835361
82Gait imbalance (HP:0002141)2.13462832
83Status epilepticus (HP:0002133)2.10818922
84Tented upper lip vermilion (HP:0010804)2.09327287
85Impaired vibration sensation in the lower limbs (HP:0002166)2.08317820
86Athetosis (HP:0002305)2.07552708
87Ectopic kidney (HP:0000086)2.05097788
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05094320
89Abnormality of polysaccharide metabolism (HP:0011012)2.05094320
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05094320
91Hypothermia (HP:0002045)2.03229414
92Abnormal mitochondria in muscle tissue (HP:0008316)2.02738170
93Dysmetria (HP:0001310)2.02203765
94Conjugated hyperbilirubinemia (HP:0002908)2.00555959
95Progressive microcephaly (HP:0000253)2.00249239
96Chorioretinal atrophy (HP:0000533)1.99875405
97Bulbous nose (HP:0000414)1.99513363
98Increased corneal curvature (HP:0100692)1.99469217
99Keratoconus (HP:0000563)1.99469217
100Limb dystonia (HP:0002451)1.99207655
101Short phalanx of the thumb (HP:0009660)1.98899232
102Abnormality of the renal collecting system (HP:0004742)1.98482767
103Aplasia/Hypoplasia of the patella (HP:0006498)1.97339026
104Abnormality of ocular smooth pursuit (HP:0000617)1.97127268
105Fair hair (HP:0002286)1.96860163
106Abnormality of the lower motor neuron (HP:0002366)1.96139028
107Drooling (HP:0002307)1.95961230
108Excessive salivation (HP:0003781)1.95961230
109Hypoplasia of the pons (HP:0012110)1.95849540
110Urinary bladder sphincter dysfunction (HP:0002839)1.95656214
111* Spastic tetraplegia (HP:0002510)1.95515816
112Broad-based gait (HP:0002136)1.95405366
113Depression (HP:0000716)1.95330405
114Pendular nystagmus (HP:0012043)1.95289180
115Hypoventilation (HP:0002791)1.94773535
116Blue irides (HP:0000635)1.92564137
117Lissencephaly (HP:0001339)1.92551976
118Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90833127
119Prolonged QT interval (HP:0001657)1.90088928
120Abolished electroretinogram (ERG) (HP:0000550)1.89925939
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88079152
122Bradykinesia (HP:0002067)1.87716068
123Mutism (HP:0002300)1.87279147
124Patellar aplasia (HP:0006443)1.86970487
125Urinary glycosaminoglycan excretion (HP:0003541)1.85882423
126Mucopolysacchariduria (HP:0008155)1.85882423
127Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85707241
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.85443407
129Absent/shortened dynein arms (HP:0200106)1.85443407
130Macroglossia (HP:0000158)1.85346513
131Central scotoma (HP:0000603)1.84997366
132Hepatocellular necrosis (HP:0001404)1.84986737
133Furrowed tongue (HP:0000221)1.84315406
134Muscular hypotonia of the trunk (HP:0008936)1.83880074
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.83479273
136Poor speech (HP:0002465)1.83430225
137Abnormality of macular pigmentation (HP:0008002)1.82526942
138Pachygyria (HP:0001302)1.81609359
139Abnormal rod and cone electroretinograms (HP:0008323)1.80845152
140Gout (HP:0001997)1.80174176
141Cerebral hypomyelination (HP:0006808)1.80070502
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79957587
143Neoplasm of the peripheral nervous system (HP:0100007)1.78902635
144Ocular albinism (HP:0001107)1.78090676
145Abnormality of the pons (HP:0007361)1.76460208
146Morphological abnormality of the middle ear (HP:0008609)1.76050597
147Amyotrophic lateral sclerosis (HP:0007354)1.75691120
148Severe muscular hypotonia (HP:0006829)1.75498981
149Action tremor (HP:0002345)1.75235125
150Decreased circulating renin level (HP:0003351)1.74922016
151Hypoglycemic seizures (HP:0002173)1.74206197
152Postural instability (HP:0002172)1.73704272
153Axonal loss (HP:0003447)1.73582368
154Impaired smooth pursuit (HP:0007772)1.73478850
155Hyperactive renin-angiotensin system (HP:0000841)1.73036210
156Gaze-evoked nystagmus (HP:0000640)1.71462648
157Truncal ataxia (HP:0002078)1.71090179
158Tachypnea (HP:0002789)1.70594035
159Large for gestational age (HP:0001520)1.70547747
160Acute necrotizing encephalopathy (HP:0006965)1.70097099
161Duplicated collecting system (HP:0000081)1.69953535
162Growth hormone excess (HP:0000845)1.68649462
163Rib fusion (HP:0000902)1.68354893
164Hepatic necrosis (HP:0002605)1.67654475
165Sleep apnea (HP:0010535)1.67653872
166Congenital hepatic fibrosis (HP:0002612)1.67615863
167Hypoalbuminemia (HP:0003073)1.67345849
168Generalized hypopigmentation of hair (HP:0011358)1.67053327
169Abnormality of the motor neurons (HP:0002450)1.66371417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.94170806
2NTRK33.63854908
3MAP2K72.95948955
4MAP3K92.82325419
5MINK12.68938780
6CDK192.68042953
7MAP3K42.56879453
8MARK12.56548934
9SIK32.39569474
10BMPR1B2.31142593
11ADRBK22.22761613
12GRK12.13460514
13RIPK42.09969054
14MAP2K42.01417525
15DAPK21.86797351
16CAMKK21.83460485
17CCNB11.78058148
18CAMK1G1.76788441
19NME11.74928579
20PRPF4B1.70183101
21MAP4K21.69054676
22ACVR1B1.68092048
23LIMK11.66013329
24CAMK1D1.65629063
25CAMKK11.61811837
26KSR11.58976616
27AKT31.58345668
28DAPK11.57914331
29ARAF1.56128896
30TLK11.52961855
31FES1.52027495
32MAP3K21.51349558
33PAK61.50531892
34EPHA41.49856605
35TESK11.45111447
36SGK2231.44530259
37SGK4941.44530259
38FGFR21.42783922
39PLK21.39891883
40FER1.38762943
41SIK21.35952073
42TXK1.32721904
43CDK51.31354493
44OXSR11.30029575
45PNCK1.27737250
46PRKD31.23475740
47SGK21.22123034
48KSR21.21888068
49PHKG21.21700689
50PHKG11.21700689
51BCR1.19738738
52ADRBK11.19617262
53WNK11.18270559
54TAOK21.16178118
55SCYL21.09081367
56PRKCG1.06536470
57PRKD21.05310292
58STK111.04853201
59BMPR21.04638862
60BRSK11.03311505
61NUAK11.02965080
62STK241.01542201
63PTK2B0.99186989
64WNK30.97803740
65CAMK2B0.97182283
66CASK0.96837286
67SYK0.95561677
68IRAK40.95448178
69MAP3K110.92305800
70SGK30.91684619
71NTRK10.88477704
72TAOK10.86584704
73ERBB30.85399706
74BRAF0.85356254
75BLK0.84095390
76CDK120.83679996
77INSRR0.83477127
78MAPK130.82615384
79GRK50.81322622
80MAP3K10.81176505
81PDPK10.79466753
82CSNK1A1L0.79426651
83CDK180.78399817
84UHMK10.78256133
85MAPK150.75974390
86MUSK0.75703640
87PRKCH0.73951886
88STK380.73127692
89TAOK30.71951366
90CSNK1G20.71730849
91RET0.71686081
92NEK60.70773477
93CAMK10.70268285
94PIK3CA0.69111444
95PDK10.69071323
96CAMK40.68305638
97CAMK2G0.68128335
98CDK140.68072127
99MAPK120.67736249
100DYRK20.67533876
101PINK10.65608002
102SGK10.65078589
103STK390.64556195
104MARK20.64533853
105PRKCZ0.63893844
106ERBB20.63429441
107CAMK2D0.63179791
108CDK150.62160387
109TNIK0.62019472
110PRKCE0.61200821
111PRKAA10.59614668
112CAMK2A0.59448662
113NTRK20.58115465
114MAPKAPK30.57944060
115HIPK20.57422927
116PKN10.56359977
117CDC42BPA0.56037724
118DYRK1A0.55127124
119BRD40.54551425
120MAP3K130.54542854
121ZAP700.53871212
122TGFBR10.53149278
123TNK20.50870705
124FRK0.50225556
125CSNK1D0.50092368
126IRAK30.49181357
127CDK11A0.48447220
128EIF2AK10.48410308
129MAP2K60.47865125
130MAP4K10.47507059
131TRPM70.47407297
132ALK0.46637621
133MAP2K10.46025022
134TSSK60.45827409
135TYRO30.44343600
136WNK40.44278530
137RPS6KA20.43832941
138PAK30.41743015
139PRKAA20.41404532
140MAPKAPK50.41215904
141PRKCB0.41092222
142RPS6KA30.41074308
143MAPK80.40762220
144CSNK1A10.40340326
145CSNK1G30.39636693
146FYN0.39494465
147PRKACA0.39322661
148MAP3K50.37715850
149PRKCQ0.37379688
150KIT0.37354415
151PRKG10.37273514
152ERN10.35968409
153ROCK20.35814275

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.85289668
2Collecting duct acid secretion_Homo sapiens_hsa049663.57530552
3Nicotine addiction_Homo sapiens_hsa050333.03805857
4Vibrio cholerae infection_Homo sapiens_hsa051102.92013468
5GABAergic synapse_Homo sapiens_hsa047272.32438436
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29735821
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26300745
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23486164
9Circadian entrainment_Homo sapiens_hsa047132.20936059
10Olfactory transduction_Homo sapiens_hsa047402.11191913
11Long-term potentiation_Homo sapiens_hsa047202.08718388
12Morphine addiction_Homo sapiens_hsa050322.02159701
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.99476190
14Phototransduction_Homo sapiens_hsa047441.97040691
15Insulin secretion_Homo sapiens_hsa049111.84673715
16Glutamatergic synapse_Homo sapiens_hsa047241.83829213
17Dopaminergic synapse_Homo sapiens_hsa047281.80788478
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.72693625
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67619963
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62810772
21Amphetamine addiction_Homo sapiens_hsa050311.62465299
22Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.60187504
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58902384
24Nitrogen metabolism_Homo sapiens_hsa009101.48015558
25Cholinergic synapse_Homo sapiens_hsa047251.47918907
26Phagosome_Homo sapiens_hsa041451.47864721
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45953393
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43753772
29Dorso-ventral axis formation_Homo sapiens_hsa043201.42449317
30Taste transduction_Homo sapiens_hsa047421.40693707
31Salivary secretion_Homo sapiens_hsa049701.33033575
32Linoleic acid metabolism_Homo sapiens_hsa005911.31790608
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29587676
34Serotonergic synapse_Homo sapiens_hsa047261.29103876
35Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.29082387
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24833140
37Lysosome_Homo sapiens_hsa041421.21944443
38Oxidative phosphorylation_Homo sapiens_hsa001901.21411194
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19372667
40Long-term depression_Homo sapiens_hsa047301.17261678
41Gastric acid secretion_Homo sapiens_hsa049711.16882825
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13161301
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12913423
44Ether lipid metabolism_Homo sapiens_hsa005651.08262920
45Rheumatoid arthritis_Homo sapiens_hsa053231.04139070
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02414813
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01985490
48Protein export_Homo sapiens_hsa030600.97162935
49Ovarian steroidogenesis_Homo sapiens_hsa049130.97141969
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.96119786
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.91470620
52Arginine biosynthesis_Homo sapiens_hsa002200.91276313
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89289961
54Type II diabetes mellitus_Homo sapiens_hsa049300.88676773
55Cocaine addiction_Homo sapiens_hsa050300.87629810
56Sulfur metabolism_Homo sapiens_hsa009200.85255957
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84283862
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81622562
59Circadian rhythm_Homo sapiens_hsa047100.79827419
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79513283
61Pyruvate metabolism_Homo sapiens_hsa006200.78905094
62Fatty acid biosynthesis_Homo sapiens_hsa000610.77277747
63Alzheimers disease_Homo sapiens_hsa050100.76797333
64Parkinsons disease_Homo sapiens_hsa050120.76794181
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76588360
66GnRH signaling pathway_Homo sapiens_hsa049120.74949636
67MAPK signaling pathway_Homo sapiens_hsa040100.74804805
68Glycerolipid metabolism_Homo sapiens_hsa005610.74658710
69Lysine degradation_Homo sapiens_hsa003100.74578782
70Calcium signaling pathway_Homo sapiens_hsa040200.74182899
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73912308
72Selenocompound metabolism_Homo sapiens_hsa004500.72887681
73Type I diabetes mellitus_Homo sapiens_hsa049400.72597806
74ErbB signaling pathway_Homo sapiens_hsa040120.72159433
75Melanogenesis_Homo sapiens_hsa049160.68600833
76Oxytocin signaling pathway_Homo sapiens_hsa049210.67348700
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66984160
78Histidine metabolism_Homo sapiens_hsa003400.66788268
79Butanoate metabolism_Homo sapiens_hsa006500.64672423
80Inositol phosphate metabolism_Homo sapiens_hsa005620.63437319
81Renin secretion_Homo sapiens_hsa049240.62669010
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62412276
83Regulation of autophagy_Homo sapiens_hsa041400.61865777
84Tryptophan metabolism_Homo sapiens_hsa003800.60339797
85Cardiac muscle contraction_Homo sapiens_hsa042600.59965094
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59711003
87Ras signaling pathway_Homo sapiens_hsa040140.58797371
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.58668530
89Tuberculosis_Homo sapiens_hsa051520.56323804
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56164059
91Hedgehog signaling pathway_Homo sapiens_hsa043400.55849682
92N-Glycan biosynthesis_Homo sapiens_hsa005100.54483221
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54482205
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.54062932
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.53839601
96beta-Alanine metabolism_Homo sapiens_hsa004100.52378880
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51570080
98Thyroid hormone synthesis_Homo sapiens_hsa049180.51271268
99Proteasome_Homo sapiens_hsa030500.51076007
100Caffeine metabolism_Homo sapiens_hsa002320.50392343
101Gap junction_Homo sapiens_hsa045400.49407265
102Glioma_Homo sapiens_hsa052140.49342156
103Pancreatic secretion_Homo sapiens_hsa049720.48563990
104Bile secretion_Homo sapiens_hsa049760.47597233
105Mineral absorption_Homo sapiens_hsa049780.46458315
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.46007315
107Phenylalanine metabolism_Homo sapiens_hsa003600.45058448
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44832806
109cAMP signaling pathway_Homo sapiens_hsa040240.44412542
110Fructose and mannose metabolism_Homo sapiens_hsa000510.44150466
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44078224
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43091899
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42493402
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41833275
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.41742445
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41317671
117Galactose metabolism_Homo sapiens_hsa000520.41261648
118Rap1 signaling pathway_Homo sapiens_hsa040150.40085569
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38074978
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.37572798
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35870227
122Hippo signaling pathway_Homo sapiens_hsa043900.35549694
123Shigellosis_Homo sapiens_hsa051310.35431174
124Endocytosis_Homo sapiens_hsa041440.35240478
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35238842
126Peroxisome_Homo sapiens_hsa041460.34221181
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.33786880
128Salmonella infection_Homo sapiens_hsa051320.33295971
129Other glycan degradation_Homo sapiens_hsa005110.31872679
130Fatty acid elongation_Homo sapiens_hsa000620.31285711
131Glucagon signaling pathway_Homo sapiens_hsa049220.31149965
132ABC transporters_Homo sapiens_hsa020100.31057167
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30553453
134Basal cell carcinoma_Homo sapiens_hsa052170.30249389
135Chemical carcinogenesis_Homo sapiens_hsa052040.29657611
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29488174
137Pertussis_Homo sapiens_hsa051330.29130268
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28444309
139Endometrial cancer_Homo sapiens_hsa052130.28003423
140Estrogen signaling pathway_Homo sapiens_hsa049150.27569469
141Axon guidance_Homo sapiens_hsa043600.27432999
142Dilated cardiomyopathy_Homo sapiens_hsa054140.27189889
143Sphingolipid metabolism_Homo sapiens_hsa006000.26858585
144Fanconi anemia pathway_Homo sapiens_hsa034600.26704257
145Choline metabolism in cancer_Homo sapiens_hsa052310.24307746
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24249022
147Basal transcription factors_Homo sapiens_hsa030220.23763889

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