VPS72

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.29193512
2ribosomal small subunit assembly (GO:0000028)4.37855580
3DNA strand elongation involved in DNA replication (GO:0006271)4.37067560
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.36261589
5telomere maintenance via semi-conservative replication (GO:0032201)4.33340034
6regulation of mitochondrial translation (GO:0070129)4.26895730
7DNA strand elongation (GO:0022616)4.19692771
8DNA damage response, detection of DNA damage (GO:0042769)4.15009010
9chaperone-mediated protein transport (GO:0072321)4.09710229
10viral transcription (GO:0019083)4.02780329
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.91609116
12telomere maintenance via recombination (GO:0000722)3.89487301
13DNA replication initiation (GO:0006270)3.89065059
14translational termination (GO:0006415)3.85467921
15mitotic recombination (GO:0006312)3.84301670
16cullin deneddylation (GO:0010388)3.79906108
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75254620
18ATP synthesis coupled proton transport (GO:0015986)3.75254620
19kinetochore assembly (GO:0051382)3.70862966
20maturation of SSU-rRNA (GO:0030490)3.65231416
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.60735191
22translational elongation (GO:0006414)3.56362770
23kinetochore organization (GO:0051383)3.55480634
24telomere maintenance via telomere lengthening (GO:0010833)3.53072403
25CENP-A containing nucleosome assembly (GO:0034080)3.52342397
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51814775
27protein deneddylation (GO:0000338)3.51788406
28DNA replication checkpoint (GO:0000076)3.49913887
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48056005
30ribosomal large subunit biogenesis (GO:0042273)3.45802251
31chromatin remodeling at centromere (GO:0031055)3.41736771
32establishment of integrated proviral latency (GO:0075713)3.41471985
33DNA unwinding involved in DNA replication (GO:0006268)3.40863501
34spliceosomal snRNP assembly (GO:0000387)3.40463295
35translational initiation (GO:0006413)3.39849389
36ribosomal small subunit biogenesis (GO:0042274)3.39368231
37respiratory electron transport chain (GO:0022904)3.39330949
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36670373
39protein targeting to mitochondrion (GO:0006626)3.35100951
40formation of translation preinitiation complex (GO:0001731)3.35063948
41peptidyl-arginine omega-N-methylation (GO:0035247)3.34982045
42mitochondrial respiratory chain complex assembly (GO:0033108)3.33074959
43proteasome assembly (GO:0043248)3.33049479
44oxidative phosphorylation (GO:0006119)3.32989643
45electron transport chain (GO:0022900)3.32438755
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31270345
47protein complex biogenesis (GO:0070271)3.31177346
48mitotic metaphase plate congression (GO:0007080)3.31101071
49pseudouridine synthesis (GO:0001522)3.30675360
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29396876
51base-excision repair, AP site formation (GO:0006285)3.28561890
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.28079444
53rRNA modification (GO:0000154)3.27882011
54iron-sulfur cluster assembly (GO:0016226)3.27680595
55metallo-sulfur cluster assembly (GO:0031163)3.27680595
56DNA replication-independent nucleosome assembly (GO:0006336)3.26826339
57DNA replication-independent nucleosome organization (GO:0034724)3.26826339
58pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.26186832
59cotranslational protein targeting to membrane (GO:0006613)3.23681853
60protein targeting to ER (GO:0045047)3.22975642
61negative regulation of RNA splicing (GO:0033119)3.21608599
62histone arginine methylation (GO:0034969)3.21475649
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.21258049
64NADH dehydrogenase complex assembly (GO:0010257)3.21258049
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21258049
66viral mRNA export from host cell nucleus (GO:0046784)3.21162402
67transcription-coupled nucleotide-excision repair (GO:0006283)3.20206739
68pyrimidine nucleotide catabolic process (GO:0006244)3.19014544
69regulation of cellular amino acid metabolic process (GO:0006521)3.15415569
70protein localization to kinetochore (GO:0034501)3.13123082
71spliceosomal complex assembly (GO:0000245)3.12603904
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11237034
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11237034
74establishment of protein localization to mitochondrion (GO:0072655)3.11043161
75protein localization to mitochondrion (GO:0070585)3.10268476
76protein localization to chromosome, centromeric region (GO:0071459)3.10257364
77viral life cycle (GO:0019058)3.09832064
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09339591
79pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.07628763
80ribonucleoprotein complex biogenesis (GO:0022613)3.07419988
81pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.05674589
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04824320
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04824320
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04824320
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04596789
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04581637
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04581637
88signal transduction involved in cell cycle checkpoint (GO:0072395)3.04490154
89peptidyl-histidine modification (GO:0018202)3.04276259
90nucleobase biosynthetic process (GO:0046112)3.03190843
91cellular protein complex disassembly (GO:0043624)3.02548195
92establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02489743
93mitotic nuclear envelope disassembly (GO:0007077)3.01563165
94protein localization to endoplasmic reticulum (GO:0070972)3.01549032
95signal transduction involved in DNA damage checkpoint (GO:0072422)3.00674973
96signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00674973
97RNA splicing, via transesterification reactions (GO:0000375)2.97822011
98mRNA splicing, via spliceosome (GO:0000398)2.96948417
99RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.96948417
100histone H2A acetylation (GO:0043968)2.96865959
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95049854
102negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93119408
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90886427
104metaphase plate congression (GO:0051310)2.90111996
105protein complex disassembly (GO:0043241)2.89722031
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89403980
107positive regulation of ligase activity (GO:0051351)2.88810234
108purine nucleobase biosynthetic process (GO:0009113)2.88208536
109IMP biosynthetic process (GO:0006188)2.88006678
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.87586767
111termination of RNA polymerase III transcription (GO:0006386)2.87586767
112ribosome biogenesis (GO:0042254)2.87421712
113deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.87217957
114peptidyl-arginine N-methylation (GO:0035246)2.87210369
115peptidyl-arginine methylation (GO:0018216)2.87210369
116ubiquinone biosynthetic process (GO:0006744)2.86492393
117cellular component biogenesis (GO:0044085)2.86465178
118rRNA processing (GO:0006364)2.86377633
119regulation of ubiquitin-protein transferase activity (GO:0051438)2.85621366
1207-methylguanosine mRNA capping (GO:0006370)2.84813325
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84638299
122negative regulation of telomere maintenance (GO:0032205)2.84060010
123histone exchange (GO:0043486)2.83835666
124inner mitochondrial membrane organization (GO:0007007)2.83371180
125rRNA methylation (GO:0031167)2.83058098
126L-serine metabolic process (GO:0006563)2.81358855
127DNA double-strand break processing (GO:0000729)2.81005241
128DNA replication-dependent nucleosome assembly (GO:0006335)2.80163477
129DNA replication-dependent nucleosome organization (GO:0034723)2.80163477
130guanosine-containing compound biosynthetic process (GO:1901070)2.78779739
131rRNA metabolic process (GO:0016072)2.77471395
132CTP metabolic process (GO:0046036)2.77435612
133CTP biosynthetic process (GO:0006241)2.77435612
134nuclear-transcribed mRNA catabolic process (GO:0000956)2.77059448
135negative regulation of chromosome segregation (GO:0051985)2.77005122
136negative regulation of mRNA processing (GO:0050686)2.76853128
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76204712
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76204712
139negative regulation of sister chromatid segregation (GO:0033046)2.76204712
140negative regulation of mitotic sister chromatid separation (GO:2000816)2.76204712
141positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.76156110
1427-methylguanosine RNA capping (GO:0009452)2.75693909
143RNA capping (GO:0036260)2.75693909
144macromolecular complex disassembly (GO:0032984)2.75410723
145tRNA aminoacylation for protein translation (GO:0006418)2.75299245
146mitotic spindle assembly checkpoint (GO:0007094)2.75026039
147negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74808565
148establishment of viral latency (GO:0019043)2.74407350
149ATP-dependent chromatin remodeling (GO:0043044)2.74264044
150amino acid activation (GO:0043038)2.73814685
151tRNA aminoacylation (GO:0043039)2.73814685
152de novo posttranslational protein folding (GO:0051084)2.73768228
153ubiquinone metabolic process (GO:0006743)2.73766704
154intra-S DNA damage checkpoint (GO:0031573)2.73460700
155nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73339213
156regulation of double-strand break repair via homologous recombination (GO:0010569)2.72887281
157spindle assembly checkpoint (GO:0071173)2.71823738
158telomere maintenance (GO:0000723)2.71810517
159membrane disassembly (GO:0030397)2.70818484
160nuclear envelope disassembly (GO:0051081)2.70818484
161translation (GO:0006412)2.70283069
162maturation of 5.8S rRNA (GO:0000460)2.69722820
163base-excision repair (GO:0006284)2.69299671
164telomere organization (GO:0032200)2.69267115
165regulation of nuclear cell cycle DNA replication (GO:0033262)2.69141623
166folic acid-containing compound biosynthetic process (GO:0009396)2.68964367
167termination of RNA polymerase II transcription (GO:0006369)2.68882649
168negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68821226
169negative regulation of ligase activity (GO:0051352)2.68821226

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.39801049
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.98964539
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67281713
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.47105030
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27370082
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11877526
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11736042
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93602679
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86864855
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.84605754
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.82081479
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78036971
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77019308
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66116720
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63159357
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.62371667
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52857963
18* XRN2_22483619_ChIP-Seq_HELA_Human2.50131821
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48490445
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37602548
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21188887
22* VDR_23849224_ChIP-Seq_CD4+_Human2.12393836
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03980150
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03240806
25CIITA_25753668_ChIP-Seq_RAJI_Human2.01191292
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99635805
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97409781
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93728810
29TTF2_22483619_ChIP-Seq_HELA_Human1.92358301
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.91248632
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.90830924
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88326356
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87682812
34DCP1A_22483619_ChIP-Seq_HELA_Human1.87164844
35MYC_22102868_ChIP-Seq_BL_Human1.85479082
36GABP_19822575_ChIP-Seq_HepG2_Human1.84476792
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83750245
38* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80898809
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.76620658
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71944367
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.69564903
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.69545448
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.65979722
44* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62545458
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60781307
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58947007
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56016721
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54675007
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.53315522
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52406978
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51924601
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48494508
53VDR_21846776_ChIP-Seq_THP-1_Human1.48481580
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48356729
55AR_21909140_ChIP-Seq_LNCAP_Human1.46200499
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46032494
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44517529
58* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42101988
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41225491
60ELK1_19687146_ChIP-ChIP_HELA_Human1.39756835
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39164299
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35759419
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32876064
64* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30274874
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28634926
66* KDM5A_27292631_Chip-Seq_BREAST_Human1.28517659
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27765486
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26556078
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24313249
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.22550293
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21787504
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21692609
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15264736
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15079308
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12683696
76CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09608827
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07913209
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07758407
79* FOXP1_21924763_ChIP-Seq_HESCs_Human1.07640249
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07141380
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05771883
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05199741
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05160277
84* SPI1_23547873_ChIP-Seq_NB4_Human1.05050767
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04862570
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03687649
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03268331
88MYC_18940864_ChIP-ChIP_HL60_Human1.02504054
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.01676419
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01611773
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00876899
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00531328
93TFEB_21752829_ChIP-Seq_HELA_Human1.00164600
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98339861
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98231016
96* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97118389
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95574867
98TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95145436
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95031239
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94487321
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94398333
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.92686631
103* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91318648
104* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91089638
105NANOG_16153702_ChIP-ChIP_HESCs_Human0.88793366
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86925261
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86606850
108* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86531297
109* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84677710
110UTX_26944678_Chip-Seq_JUKART_Human0.84534370
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.84514733
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83851892
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83405610
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.82822078
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82260829
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81387926
117PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80444091
118MAF_26560356_Chip-Seq_TH2_Human0.79389717
119TET1_21451524_ChIP-Seq_MESCs_Mouse0.77659819
120* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75697363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.33749738
2MP0003111_abnormal_nucleus_morphology3.78575742
3MP0010094_abnormal_chromosome_stability3.60975454
4MP0003077_abnormal_cell_cycle3.33793286
5MP0008007_abnormal_cellular_replicative3.25625688
6MP0001529_abnormal_vocalization3.11976293
7MP0004957_abnormal_blastocyst_morpholog3.10330431
8MP0008058_abnormal_DNA_repair3.02804539
9MP0002822_catalepsy2.87358020
10MP0010030_abnormal_orbit_morphology2.83658678
11MP0008057_abnormal_DNA_replication2.34712880
12MP0008932_abnormal_embryonic_tissue2.34525651
13MP0005499_abnormal_olfactory_system2.18622838
14MP0005394_taste/olfaction_phenotype2.18622838
15MP0002396_abnormal_hematopoietic_system2.14104110
16MP0000372_irregular_coat_pigmentation2.07178309
17MP0000490_abnormal_crypts_of1.99393162
18MP0002234_abnormal_pharynx_morphology1.98809217
19MP0003786_premature_aging1.94212129
20MP0006292_abnormal_olfactory_placode1.91482019
21MP0006036_abnormal_mitochondrial_physio1.82386953
22MP0002653_abnormal_ependyma_morphology1.78382387
23MP0006035_abnormal_mitochondrial_morpho1.72351694
24MP0000350_abnormal_cell_proliferation1.71993965
25MP0003315_abnormal_perineum_morphology1.71856515
26MP0003763_abnormal_thymus_physiology1.68826791
27MP0003123_paternal_imprinting1.65815458
28MP0003806_abnormal_nucleotide_metabolis1.64706289
29MP0001188_hyperpigmentation1.63038165
30MP0003880_abnormal_central_pattern1.56510330
31MP0001730_embryonic_growth_arrest1.53719712
32MP0000566_synostosis1.52894396
33MP0006276_abnormal_autonomic_nervous1.51002218
34MP0009333_abnormal_splenocyte_physiolog1.48138537
35MP0003186_abnormal_redox_activity1.47930289
36MP0002132_abnormal_respiratory_system1.47419905
37MP0004145_abnormal_muscle_electrophysio1.41579577
38MP0002736_abnormal_nociception_after1.41003086
39MP0001984_abnormal_olfaction1.40521654
40MP0000049_abnormal_middle_ear1.40354710
41MP0004233_abnormal_muscle_weight1.40241839
42MP0003136_yellow_coat_color1.36566103
43MP0003122_maternal_imprinting1.35759251
44MP0005423_abnormal_somatic_nervous1.31350757
45MP0001672_abnormal_embryogenesis/_devel1.30681268
46MP0005380_embryogenesis_phenotype1.30681268
47MP0001697_abnormal_embryo_size1.29506762
48MP0000313_abnormal_cell_death1.28087107
49MP0002085_abnormal_embryonic_tissue1.26651961
50MP0004808_abnormal_hematopoietic_stem1.24072719
51MP0002019_abnormal_tumor_incidence1.23361526
52MP0003718_maternal_effect1.23299965
53MP0002249_abnormal_larynx_morphology1.22405985
54MP0002938_white_spotting1.21425840
55MP0009672_abnormal_birth_weight1.21207421
56MP0003567_abnormal_fetal_cardiomyocyte1.20027509
57MP0002080_prenatal_lethality1.19640790
58MP0000678_abnormal_parathyroid_gland1.18778741
59MP0002638_abnormal_pupillary_reflex1.18479872
60MP0004133_heterotaxia1.16929378
61MP0000751_myopathy1.16516206
62MP0002102_abnormal_ear_morphology1.16326078
63MP0009053_abnormal_anal_canal1.15935959
64MP0003984_embryonic_growth_retardation1.15504456
65MP0000703_abnormal_thymus_morphology1.15058285
66MP0002398_abnormal_bone_marrow1.14983015
67MP0002163_abnormal_gland_morphology1.13023691
68MP0003221_abnormal_cardiomyocyte_apopto1.12730805
69MP0003646_muscle_fatigue1.12277808
70MP0001293_anophthalmia1.12235767
71MP0002088_abnormal_embryonic_growth/wei1.12107411
72MP0008789_abnormal_olfactory_epithelium1.10885475
73MP0008877_abnormal_DNA_methylation1.10874832
74MP0005075_abnormal_melanosome_morpholog1.09048141
75MP0003941_abnormal_skin_development1.08527316
76MP0001545_abnormal_hematopoietic_system1.08368243
77MP0005397_hematopoietic_system_phenotyp1.08368243
78MP0003121_genomic_imprinting1.07040099
79MP0002233_abnormal_nose_morphology1.07016149
80MP0006072_abnormal_retinal_apoptosis1.06803199
81MP0005645_abnormal_hypothalamus_physiol1.05882428
82MP0004270_analgesia1.05840822
83MP0010352_gastrointestinal_tract_polyps1.05619598
84MP0003787_abnormal_imprinting1.05422408
85MP0000631_abnormal_neuroendocrine_gland1.05060791
86MP0000358_abnormal_cell_content/1.04998196
87MP0008995_early_reproductive_senescence1.04814254
88MP0000537_abnormal_urethra_morphology1.04083277
89MP0005187_abnormal_penis_morphology1.03664828
90MP0002084_abnormal_developmental_patter1.03592471
91MP0001905_abnormal_dopamine_level1.01642897
92MP0002722_abnormal_immune_system0.99859367
93MP0003938_abnormal_ear_development0.98416425
94MP0003119_abnormal_digestive_system0.97051478
95MP0004197_abnormal_fetal_growth/weight/0.97024896
96MP0000858_altered_metastatic_potential0.96235763
97MP0002210_abnormal_sex_determination0.96086166
98MP0000689_abnormal_spleen_morphology0.95757961
99MP0000749_muscle_degeneration0.94214405
100MP0004142_abnormal_muscle_tone0.93713921
101MP0001727_abnormal_embryo_implantation0.93607848
102MP0002697_abnormal_eye_size0.93424758
103MP0001119_abnormal_female_reproductive0.93263392
104MP0001968_abnormal_touch/_nociception0.93203084
105MP0002932_abnormal_joint_morphology0.92400155
106MP0000516_abnormal_urinary_system0.92111897
107MP0005367_renal/urinary_system_phenotyp0.92111897
108MP0002184_abnormal_innervation0.91574743
109MP0002086_abnormal_extraembryonic_tissu0.91283287
110MP0003861_abnormal_nervous_system0.90514990
111MP0000685_abnormal_immune_system0.90016797
112MP0004811_abnormal_neuron_physiology0.88934329
113MP0002429_abnormal_blood_cell0.88688215
114MP0002160_abnormal_reproductive_system0.88318194
115MP0000750_abnormal_muscle_regeneration0.87278195
116MP0000778_abnormal_nervous_system0.87123999
117MP0001346_abnormal_lacrimal_gland0.86935404
118MP0005671_abnormal_response_to0.86811301
119MP0005076_abnormal_cell_differentiation0.84841725
120MP0002111_abnormal_tail_morphology0.83331871
121MP0009278_abnormal_bone_marrow0.82895404
122MP0001835_abnormal_antigen_presentation0.82218405
123MP0002751_abnormal_autonomic_nervous0.82138351
124MP0002269_muscular_atrophy0.82024470
125MP0003937_abnormal_limbs/digits/tail_de0.81723979
126MP0000955_abnormal_spinal_cord0.81535473
127MP0003385_abnormal_body_wall0.81471401
128MP0005174_abnormal_tail_pigmentation0.80549570
129MP0005171_absent_coat_pigmentation0.80116110
130MP0003942_abnormal_urinary_system0.79286125
131MP0001286_abnormal_eye_development0.79137950
132MP0000716_abnormal_immune_system0.78921740
133MP0001764_abnormal_homeostasis0.78401397
134MP0002277_abnormal_respiratory_mucosa0.77605436
135MP0001929_abnormal_gametogenesis0.75303814
136MP0000647_abnormal_sebaceous_gland0.74780110
137MP0010307_abnormal_tumor_latency0.74349831
138MP0009379_abnormal_foot_pigmentation0.74066646
139MP0001145_abnormal_male_reproductive0.73575181
140MP0006054_spinal_hemorrhage0.72657961
141MP0000428_abnormal_craniofacial_morphol0.72266192
142MP0002095_abnormal_skin_pigmentation0.71255001
143MP0005670_abnormal_white_adipose0.70388342
144MP0002420_abnormal_adaptive_immunity0.70290120
145MP0003890_abnormal_embryonic-extraembry0.69615050
146MP0001819_abnormal_immune_cell0.69567920
147MP0008260_abnormal_autophagy0.67813488
148MP0005023_abnormal_wound_healing0.67786603
149MP0002177_abnormal_outer_ear0.67407717
150MP0000477_abnormal_intestine_morphology0.65967030
151MP0009250_abnormal_appendicular_skeleto0.65630548
152MP0000653_abnormal_sex_gland0.65598489
153MP0001800_abnormal_humoral_immune0.65484331
154MP0001849_ear_inflammation0.65480537
155MP0002452_abnormal_antigen_presenting0.65476393

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)4.82106140
2Acute necrotizing encephalopathy (HP:0006965)4.78133525
3Acute encephalopathy (HP:0006846)4.34961540
4Hepatocellular necrosis (HP:0001404)4.08260780
5Mitochondrial inheritance (HP:0001427)4.04933048
6Reticulocytopenia (HP:0001896)4.04346132
7Abnormal number of erythroid precursors (HP:0012131)4.00237114
8Abnormality of cells of the erythroid lineage (HP:0012130)3.92969455
9Hepatic necrosis (HP:0002605)3.82095302
10Progressive macrocephaly (HP:0004481)3.78858037
11Increased CSF lactate (HP:0002490)3.77316562
12Aplastic anemia (HP:0001915)3.73748445
13Birth length less than 3rd percentile (HP:0003561)3.54105256
14Patellar aplasia (HP:0006443)3.40997770
15Aplasia/Hypoplasia of the patella (HP:0006498)3.31458739
16Degeneration of anterior horn cells (HP:0002398)3.26039845
17Abnormality of the anterior horn cell (HP:0006802)3.26039845
18Increased intramyocellular lipid droplets (HP:0012240)3.19993699
19Cerebral edema (HP:0002181)3.11628980
20Breast hypoplasia (HP:0003187)3.10609360
21Selective tooth agenesis (HP:0001592)3.06833100
22Abnormality of the labia minora (HP:0012880)3.02918272
23Oral leukoplakia (HP:0002745)2.95625922
24Chromsome breakage (HP:0040012)2.95376727
25Exercise intolerance (HP:0003546)2.94231497
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92050286
27Lactic acidosis (HP:0003128)2.91261082
28Increased hepatocellular lipid droplets (HP:0006565)2.91245264
293-Methylglutaconic aciduria (HP:0003535)2.86523803
30Meckel diverticulum (HP:0002245)2.85750446
31Increased serum lactate (HP:0002151)2.84313745
32Pallor (HP:0000980)2.79371541
33Abnormality of the ileum (HP:0001549)2.75891700
34Short middle phalanx of the 5th finger (HP:0004220)2.74644778
35Lipid accumulation in hepatocytes (HP:0006561)2.66282765
36Abnormality of the preputium (HP:0100587)2.66124580
37Microvesicular hepatic steatosis (HP:0001414)2.65898975
38Increased muscle lipid content (HP:0009058)2.64548613
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.57703350
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57295627
41Macrocytic anemia (HP:0001972)2.53292294
42Respiratory failure (HP:0002878)2.49826956
43Abnormality of glycolysis (HP:0004366)2.49431515
44Trismus (HP:0000211)2.42600805
45Type I transferrin isoform profile (HP:0003642)2.39116708
46Absent thumb (HP:0009777)2.39060928
47Renal Fanconi syndrome (HP:0001994)2.35674832
48Microretrognathia (HP:0000308)2.35167219
49Optic nerve coloboma (HP:0000588)2.33893949
50Rough bone trabeculation (HP:0100670)2.33793097
51Colon cancer (HP:0003003)2.32856051
52Poor suck (HP:0002033)2.32698883
53Increased serum pyruvate (HP:0003542)2.29436661
54Retinal dysplasia (HP:0007973)2.26552508
55Triphalangeal thumb (HP:0001199)2.25896517
56Medulloblastoma (HP:0002885)2.24923212
57Abnormal number of incisors (HP:0011064)2.24806043
58Hyperglycinemia (HP:0002154)2.24777299
59Leukodystrophy (HP:0002415)2.24681244
60Abnormality of the aortic arch (HP:0012303)2.23247428
61Abnormal protein glycosylation (HP:0012346)2.22755807
62Abnormal glycosylation (HP:0012345)2.22755807
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22755807
64Abnormal protein N-linked glycosylation (HP:0012347)2.22755807
65Small intestinal stenosis (HP:0012848)2.22331352
66Duodenal stenosis (HP:0100867)2.22331352
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20293501
68Abnormality of chromosome stability (HP:0003220)2.19448758
69Abnormal lung lobation (HP:0002101)2.19356706
70Muscle fiber atrophy (HP:0100295)2.17569899
71Exercise-induced muscle cramps (HP:0003710)2.16726381
72Myelodysplasia (HP:0002863)2.16061428
73Slender long bone (HP:0003100)2.13039729
74Tracheoesophageal fistula (HP:0002575)2.11692268
75Cortical dysplasia (HP:0002539)2.10663881
76Neoplasm of the pancreas (HP:0002894)2.09374423
77Ectopic kidney (HP:0000086)2.08504529
78Thrombocytosis (HP:0001894)2.08245435
79Rimmed vacuoles (HP:0003805)2.07739186
80Premature graying of hair (HP:0002216)2.07712875
81Carpal bone hypoplasia (HP:0001498)2.06454324
82Bone marrow hypocellularity (HP:0005528)2.05087602
83Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.04881543
84Broad distal phalanx of finger (HP:0009836)2.04831459
85Abnormal gallbladder physiology (HP:0012438)2.04540746
86Cholecystitis (HP:0001082)2.04540746
87Shoulder girdle muscle weakness (HP:0003547)2.04426244
88Pendular nystagmus (HP:0012043)2.04296547
89Emotional lability (HP:0000712)2.04278673
90Abnormality of the metopic suture (HP:0005556)2.02687119
91Absent radius (HP:0003974)1.99242539
92Atrophy/Degeneration involving motor neurons (HP:0007373)1.98393792
93Prominent metopic ridge (HP:0005487)1.97262669
94Rib fusion (HP:0000902)1.93928961
95Ragged-red muscle fibers (HP:0003200)1.93741117
96Overlapping toe (HP:0001845)1.93657508
97Progressive muscle weakness (HP:0003323)1.93037734
98Atresia of the external auditory canal (HP:0000413)1.93019809
99Optic disc pallor (HP:0000543)1.92703589
100Type 2 muscle fiber atrophy (HP:0003554)1.92649788
101Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91613116
10211 pairs of ribs (HP:0000878)1.90788938
103Petechiae (HP:0000967)1.89924574
104Abnormality of the duodenum (HP:0002246)1.89467126
105Progressive microcephaly (HP:0000253)1.88098158
106IgM deficiency (HP:0002850)1.86634692
107Short 5th finger (HP:0009237)1.85088452
108Aplasia involving forearm bones (HP:0009822)1.84892460
109Absent forearm bone (HP:0003953)1.84892460
110Multiple enchondromatosis (HP:0005701)1.84329019
111Cleft eyelid (HP:0000625)1.83926974
112Lethargy (HP:0001254)1.82917147
113Respiratory difficulties (HP:0002880)1.82663173
114Abnormality of the carotid arteries (HP:0005344)1.82400762
115Abnormality of DNA repair (HP:0003254)1.81659689
116CNS demyelination (HP:0007305)1.80844048
117Generalized aminoaciduria (HP:0002909)1.80158738
118Impulsivity (HP:0100710)1.79460335
119Hyperacusis (HP:0010780)1.79258613
120Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79028991
121Short 4th metacarpal (HP:0010044)1.79028991
122Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.78994815
123Cellular immunodeficiency (HP:0005374)1.78540094
124Horseshoe kidney (HP:0000085)1.77816685
125Postnatal microcephaly (HP:0005484)1.77542874
126Nemaline bodies (HP:0003798)1.76339526
127Hypoplasia of the radius (HP:0002984)1.74129978
128Broad palm (HP:0001169)1.74020603
129Neoplasm of the adrenal gland (HP:0100631)1.73670585
130Short thumb (HP:0009778)1.72880558
131Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71909175
132Sparse eyelashes (HP:0000653)1.71866538
133Cerebral hypomyelination (HP:0006808)1.70848297
134Sloping forehead (HP:0000340)1.70250372
135X-linked dominant inheritance (HP:0001423)1.70055899
136CNS hypomyelination (HP:0003429)1.70030598
137Oligodactyly (HP:0012165)1.69931540
138Severe visual impairment (HP:0001141)1.68913308
139Depressed nasal ridge (HP:0000457)1.68145780
140Poikiloderma (HP:0001029)1.66531368
141Supernumerary spleens (HP:0009799)1.66511732
142Limb hypertonia (HP:0002509)1.65624318
143Lymphoma (HP:0002665)1.65574932
144Cutaneous melanoma (HP:0012056)1.65374939
145Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.64985275
146Testicular atrophy (HP:0000029)1.64594102
147Muscle fiber inclusion bodies (HP:0100299)1.63768435
148Calcaneovalgus deformity (HP:0001848)1.63628944
149Methylmalonic aciduria (HP:0012120)1.62381483
150Abnormality of the renal collecting system (HP:0004742)1.61959068
151Decreased activity of mitochondrial respiratory chain (HP:0008972)1.61174052
152Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.61174052
153Spinal cord lesions (HP:0100561)1.61166556
154Syringomyelia (HP:0003396)1.61166556
155Clubbing of toes (HP:0100760)1.60994775
156Renal duplication (HP:0000075)1.60292232
157Concave nail (HP:0001598)1.59747601
158Tongue fasciculations (HP:0001308)1.59469539
159Amaurosis fugax (HP:0100576)1.59012989
160Reduced antithrombin III activity (HP:0001976)1.58093761
161Increased nuchal translucency (HP:0010880)1.57821345
162Pancytopenia (HP:0001876)1.57415453
163Anophthalmia (HP:0000528)1.57029531
164Congenital malformation of the right heart (HP:0011723)1.56363667
165Double outlet right ventricle (HP:0001719)1.56363667
166Methylmalonic acidemia (HP:0002912)1.56356486
167Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.55139444
168Abnormality of alanine metabolism (HP:0010916)1.55139444
169Hyperalaninemia (HP:0003348)1.55139444
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.55113601
171Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.54874589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.46927907
2BUB14.16652018
3EIF2AK12.96253115
4WEE12.76124393
5STK162.64538448
6CDC72.64230462
7SRPK12.60596050
8TESK22.53755357
9TRIM282.48739130
10TLK12.34735037
11MAP3K102.26917337
12PLK42.15121941
13VRK12.13844721
14CSNK1G32.06241824
15DYRK32.05705516
16NEK21.98129650
17TTK1.87602072
18CDK71.80273171
19MKNK11.75732058
20BCR1.74499660
21PIM21.70473973
22ARAF1.69819153
23CSNK1G21.68044662
24PLK11.66625560
25CSNK1A1L1.65984871
26NME21.65567275
27CSNK1G11.59984317
28ACVR1B1.59616617
29MAP2K71.54181909
30MKNK21.54024765
31TSSK61.53881947
32ATR1.51988009
33PASK1.51961308
34RPS6KA41.49174070
35WNK31.49058560
36PAK41.48744343
37PBK1.46493672
38AURKB1.46481456
39MAP4K21.41003284
40TESK11.39632273
41KDR1.38408327
42EEF2K1.37406281
43RPS6KB21.33667675
44TGFBR11.25460910
45ZAK1.21268130
46MAP4K11.19891646
47TAOK21.19302247
48PDK21.16994302
49NUAK11.14387161
50EIF2AK31.14161353
51AURKA1.13770016
52CDK191.13014949
53CCNB11.12003311
54CHEK21.11828149
55DAPK11.11738587
56SIK31.10541293
57DYRK21.09865128
58CLK11.07219739
59MARK11.05590014
60BRSK21.05023551
61STK101.04822284
62CDK81.00370597
63MAP3K40.98513885
64CDK40.97741446
65MAP3K80.97402063
66PHKG20.92436788
67PHKG10.92436788
68EPHA20.91657220
69BRAF0.90800225
70IRAK40.90639993
71OBSCN0.90439049
72PLK30.89558403
73STK40.88786731
74MAPKAPK30.87098843
75YES10.86290911
76FLT30.85624868
77BRSK10.84180268
78IRAK30.84091844
79TAF10.81830202
80ILK0.81729990
81LIMK10.80023852
82CHEK10.79663572
83EPHB20.79284862
84ZAP700.78933513
85BTK0.78319722
86NEK90.77420188
87ERBB30.76871260
88MAP3K110.73667716
89MAP3K120.72792376
90CHUK0.72318475
91MAPK130.70673069
92BLK0.70637149
93CDK180.70004705
94PINK10.69856807
95PIM10.69449485
96MINK10.69058783
97CDK140.68554421
98LRRK20.67358212
99NEK10.67139183
100CDK11A0.66634028
101TXK0.65564421
102PAK10.63845575
103EIF2AK20.63832626
104CDK150.63156326
105TRIB30.61833419
106BRD40.61518643
107CDK120.61398816
108IKBKB0.61160762
109CDK20.60837598
110* CSNK2A10.58281176
111SMG10.57878527
112PRKCI0.56593861
113PKN20.55207215
114JAK30.53885676
115RAF10.52847963
116* ATM0.52518775
117AKT20.52307591
118BCKDK0.51907021
119STK240.50618546
120TBK10.49414147
121DYRK1B0.47629394
122MAP2K60.46982162
123KIT0.45657531
124CDK10.45236246
125IRAK10.43678970
126RPS6KA50.43504118
127* CSNK2A20.41319831
128STK38L0.40943698
129LMTK20.40721371
130MAPK110.39993388
131NME10.39698749
132MAPKAPK20.37134726
133MAP2K40.36855263
134ICK0.36548723
135KSR10.36375072
136NLK0.35765683
137MAPKAPK50.34617196
138UHMK10.33990330
139CSNK1A10.33455060
140PKN10.32229512
141* CSNK1E0.30588190

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.57434649
2Mismatch repair_Homo sapiens_hsa034303.77503442
3Ribosome_Homo sapiens_hsa030103.59911282
4Spliceosome_Homo sapiens_hsa030403.39118964
5Oxidative phosphorylation_Homo sapiens_hsa001903.36195224
6Base excision repair_Homo sapiens_hsa034103.22642014
7RNA polymerase_Homo sapiens_hsa030203.11039021
8Homologous recombination_Homo sapiens_hsa034403.08710712
9Proteasome_Homo sapiens_hsa030502.90189326
10Nucleotide excision repair_Homo sapiens_hsa034202.74310578
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65033564
12RNA transport_Homo sapiens_hsa030132.50266667
13Cell cycle_Homo sapiens_hsa041102.50135236
14Pyrimidine metabolism_Homo sapiens_hsa002402.40579127
15Fanconi anemia pathway_Homo sapiens_hsa034602.34983445
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12458269
17One carbon pool by folate_Homo sapiens_hsa006702.01489996
18Alzheimers disease_Homo sapiens_hsa050101.97741853
19RNA degradation_Homo sapiens_hsa030181.92098362
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82082853
21Fatty acid elongation_Homo sapiens_hsa000621.77348115
22Basal transcription factors_Homo sapiens_hsa030221.74154804
23Non-homologous end-joining_Homo sapiens_hsa034501.66120541
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61462019
25p53 signaling pathway_Homo sapiens_hsa041151.60714280
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55840936
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55507638
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55026996
29mRNA surveillance pathway_Homo sapiens_hsa030151.53693830
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49448009
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46447450
32Cardiac muscle contraction_Homo sapiens_hsa042601.45035082
33Carbon metabolism_Homo sapiens_hsa012001.38235502
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32110279
35Epstein-Barr virus infection_Homo sapiens_hsa051691.32023840
36Herpes simplex infection_Homo sapiens_hsa051681.26268895
37Sulfur relay system_Homo sapiens_hsa041221.25717913
38Purine metabolism_Homo sapiens_hsa002301.25538528
39Steroid biosynthesis_Homo sapiens_hsa001001.15054025
40Pyruvate metabolism_Homo sapiens_hsa006201.14460274
41Folate biosynthesis_Homo sapiens_hsa007901.06004109
42Propanoate metabolism_Homo sapiens_hsa006400.99754380
43Primary immunodeficiency_Homo sapiens_hsa053400.97721057
44HTLV-I infection_Homo sapiens_hsa051660.93595088
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93389153
46Notch signaling pathway_Homo sapiens_hsa043300.91124108
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90598608
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89812250
49Protein export_Homo sapiens_hsa030600.88928328
50Viral carcinogenesis_Homo sapiens_hsa052030.88409805
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88105766
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87674198
53Thyroid cancer_Homo sapiens_hsa052160.86881709
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86441347
55Antigen processing and presentation_Homo sapiens_hsa046120.84418102
56Basal cell carcinoma_Homo sapiens_hsa052170.82855965
57Legionellosis_Homo sapiens_hsa051340.81482628
58Systemic lupus erythematosus_Homo sapiens_hsa053220.80684184
59Metabolic pathways_Homo sapiens_hsa011000.79932960
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79554135
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74465819
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.73082359
63Measles_Homo sapiens_hsa051620.72769330
64Arginine and proline metabolism_Homo sapiens_hsa003300.72629059
65Apoptosis_Homo sapiens_hsa042100.69397134
66Small cell lung cancer_Homo sapiens_hsa052220.68930502
67Peroxisome_Homo sapiens_hsa041460.68863009
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65145767
69Shigellosis_Homo sapiens_hsa051310.64516485
70Selenocompound metabolism_Homo sapiens_hsa004500.64119978
71MicroRNAs in cancer_Homo sapiens_hsa052060.61557880
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.61089947
73Acute myeloid leukemia_Homo sapiens_hsa052210.60729103
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60088900
75Sulfur metabolism_Homo sapiens_hsa009200.59986384
76Vibrio cholerae infection_Homo sapiens_hsa051100.59308710
77Vitamin B6 metabolism_Homo sapiens_hsa007500.58786479
78Huntingtons disease_Homo sapiens_hsa050160.57668754
79Hippo signaling pathway_Homo sapiens_hsa043900.57290795
80Bladder cancer_Homo sapiens_hsa052190.56837053
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56630345
82Hepatitis B_Homo sapiens_hsa051610.56551564
83TGF-beta signaling pathway_Homo sapiens_hsa043500.56327137
84Chronic myeloid leukemia_Homo sapiens_hsa052200.56015634
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54162955
86Hematopoietic cell lineage_Homo sapiens_hsa046400.53884309
87Leishmaniasis_Homo sapiens_hsa051400.53476031
88Fructose and mannose metabolism_Homo sapiens_hsa000510.53026734
89Butanoate metabolism_Homo sapiens_hsa006500.52300067
90Colorectal cancer_Homo sapiens_hsa052100.51007925
91Pentose phosphate pathway_Homo sapiens_hsa000300.50980633
92Arachidonic acid metabolism_Homo sapiens_hsa005900.50891614
93Fatty acid metabolism_Homo sapiens_hsa012120.50672945
94Collecting duct acid secretion_Homo sapiens_hsa049660.50136106
95Influenza A_Homo sapiens_hsa051640.49745677
96Alcoholism_Homo sapiens_hsa050340.48779854
97Viral myocarditis_Homo sapiens_hsa054160.47966514
98Parkinsons disease_Homo sapiens_hsa050120.46989088
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46146113
100N-Glycan biosynthesis_Homo sapiens_hsa005100.45851475
101Phototransduction_Homo sapiens_hsa047440.45595871
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45594008
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45077342
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.44334396
105Hedgehog signaling pathway_Homo sapiens_hsa043400.44066588
106Oocyte meiosis_Homo sapiens_hsa041140.44021746
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40094866
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40086732
109Other glycan degradation_Homo sapiens_hsa005110.40021566
110Pathways in cancer_Homo sapiens_hsa052000.39654567
111Glutathione metabolism_Homo sapiens_hsa004800.38441080
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.37691601
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34446519
114Galactose metabolism_Homo sapiens_hsa000520.34309367
115Synaptic vesicle cycle_Homo sapiens_hsa047210.34264793
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.33769845
117beta-Alanine metabolism_Homo sapiens_hsa004100.32207150
118Biosynthesis of amino acids_Homo sapiens_hsa012300.31624007
119Nicotine addiction_Homo sapiens_hsa050330.31403943
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30259964
121Allograft rejection_Homo sapiens_hsa053300.28597943
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28220881
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27222188
124T cell receptor signaling pathway_Homo sapiens_hsa046600.25904392
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24937326
126HIF-1 signaling pathway_Homo sapiens_hsa040660.24931608
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24199164
128Toxoplasmosis_Homo sapiens_hsa051450.24105903
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24023582
130Endometrial cancer_Homo sapiens_hsa052130.23990405
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22982115
132B cell receptor signaling pathway_Homo sapiens_hsa046620.22934075
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22643185
134Non-small cell lung cancer_Homo sapiens_hsa052230.22455850
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.22130671
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22003634
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21643646
138Adherens junction_Homo sapiens_hsa045200.21568854
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.21432490
140Regulation of autophagy_Homo sapiens_hsa041400.21173575
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.20526756
142Wnt signaling pathway_Homo sapiens_hsa043100.20343370
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16449214
144Phenylalanine metabolism_Homo sapiens_hsa003600.16055757
145Tyrosine metabolism_Homo sapiens_hsa003500.13647757
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.08619483
147Lysine degradation_Homo sapiens_hsa003100.07037046
148GABAergic synapse_Homo sapiens_hsa047270.06783190

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