VPS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron projection extension involved in neuron projection guidance (GO:1902284)4.94277902
2axon extension involved in axon guidance (GO:0048846)4.94277902
3epithelial cell fate commitment (GO:0072148)4.69972858
4regulation of synapse maturation (GO:0090128)3.72215709
5response to pheromone (GO:0019236)3.66437852
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.64497947
7detection of molecule of bacterial origin (GO:0032490)3.63064122
8response to muramyl dipeptide (GO:0032495)3.60453999
9establishment of protein localization to Golgi (GO:0072600)3.54604724
10regulation of B cell receptor signaling pathway (GO:0050855)3.53675424
11chondrocyte proliferation (GO:0035988)3.51721550
12locomotory exploration behavior (GO:0035641)3.45375156
13synaptic vesicle maturation (GO:0016188)3.42342358
14neural tube formation (GO:0001841)3.38774866
15cellular response to ethanol (GO:0071361)3.36937375
16lung epithelium development (GO:0060428)3.35674683
17L-amino acid import (GO:0043092)3.34716998
18positive regulation of synapse maturation (GO:0090129)3.34094418
19barbed-end actin filament capping (GO:0051016)3.29855180
20regulation of beta-amyloid formation (GO:1902003)3.27160271
21protein targeting to Golgi (GO:0000042)3.25992307
22retrograde transport, vesicle recycling within Golgi (GO:0000301)3.21184932
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.18568914
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15396929
25monoubiquitinated protein deubiquitination (GO:0035520)3.14722971
26lens fiber cell development (GO:0070307)3.11909284
27microglial cell activation (GO:0001774)3.10119367
28positive regulation of fibroblast migration (GO:0010763)3.09945744
29regulation of sarcomere organization (GO:0060297)3.04996772
30regulation of relaxation of muscle (GO:1901077)3.00965701
31positive regulation of cellular amide metabolic process (GO:0034250)3.00665312
32regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.00390818
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93966435
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93966435
35positive regulation by organism of defense response of other organism involved in symbiotic interact2.93966435
36modulation by symbiont of host immune response (GO:0052553)2.93966435
37positive regulation by symbiont of host defense response (GO:0052509)2.93966435
38modulation by symbiont of host defense response (GO:0052031)2.93966435
39hepatocyte apoptotic process (GO:0097284)2.92610816
40Notch signaling involved in heart development (GO:0061314)2.88324332
41synaptic vesicle endocytosis (GO:0048488)2.85704536
42glycine transport (GO:0015816)2.85442777
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.84651245
44negative regulation of cell killing (GO:0031342)2.84651245
45positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.82799215
46regulation of synaptic vesicle exocytosis (GO:2000300)2.82785950
47activated T cell proliferation (GO:0050798)2.82344814
48synaptic vesicle exocytosis (GO:0016079)2.82014432
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81416834
50response to host (GO:0075136)2.81416834
51response to host defenses (GO:0052200)2.81416834
52interkinetic nuclear migration (GO:0022027)2.80852398
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80615598
54negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.79887694
55cell communication by electrical coupling (GO:0010644)2.79434476
56cellular extravasation (GO:0045123)2.78990495
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78418947
58positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.76311712
59amino acid import (GO:0043090)2.75820027
60ionotropic glutamate receptor signaling pathway (GO:0035235)2.75529333
61regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.74305493
62negative regulation of neurotransmitter transport (GO:0051589)2.73786304
63cytoplasmic mRNA processing body assembly (GO:0033962)2.73395695
64nucleus localization (GO:0051647)2.73270395
65protein K11-linked deubiquitination (GO:0035871)2.72517580
66cellular response to epinephrine stimulus (GO:0071872)2.71696147
67positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.71276241
68macroautophagy (GO:0016236)2.70757315
69glutamate secretion (GO:0014047)2.68299481
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.67085442
71negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66635386
72regulation of memory T cell differentiation (GO:0043380)2.66336033
73early endosome to late endosome transport (GO:0045022)2.66044689
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.65398510
75regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65277221
76neutrophil mediated immunity (GO:0002446)2.64759880
77regulation of establishment of cell polarity (GO:2000114)2.63323061
78regulation of protein glycosylation (GO:0060049)2.62669381
79negative regulation of oligodendrocyte differentiation (GO:0048715)2.60713169
80cardiac left ventricle morphogenesis (GO:0003214)2.57960185
81histone H3-K4 trimethylation (GO:0080182)2.57500967
82regulation of glutamate receptor signaling pathway (GO:1900449)2.57298563
83venous blood vessel morphogenesis (GO:0048845)2.57137410
84macrophage activation (GO:0042116)2.56819040
85type B pancreatic cell development (GO:0003323)2.56383059
86exocrine pancreas development (GO:0031017)2.56352166
87inner ear receptor cell differentiation (GO:0060113)2.56294608
88positive regulation of myoblast differentiation (GO:0045663)2.55844374
89central nervous system neuron axonogenesis (GO:0021955)2.55560523
90regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.53526507
91Golgi to endosome transport (GO:0006895)2.53515276
92negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.53110867
93neutrophil activation involved in immune response (GO:0002283)2.53071948
94cerebral cortex radially oriented cell migration (GO:0021799)2.51732956
95regulation of synaptic vesicle transport (GO:1902803)2.49598369
96axon ensheathment in central nervous system (GO:0032291)2.49317899
97central nervous system myelination (GO:0022010)2.49317899
98regulation of gamma-delta T cell differentiation (GO:0045586)2.49263127
99vesicle transport along microtubule (GO:0047496)2.48905326
100positive regulation of muscle hypertrophy (GO:0014742)2.46641286
101positive regulation of cardiac muscle hypertrophy (GO:0010613)2.46641286
102synaptic transmission, glutamatergic (GO:0035249)2.45698270
103leukocyte migration involved in inflammatory response (GO:0002523)2.44002730
104regulation of gamma-delta T cell activation (GO:0046643)2.43224146
105protein K48-linked deubiquitination (GO:0071108)2.43162385
106regulation of ARF protein signal transduction (GO:0032012)2.43011795
107proline transport (GO:0015824)2.42463511
108cerebellar Purkinje cell differentiation (GO:0021702)2.41288261
109regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.40929905
110axon extension (GO:0048675)2.39923754
111prenylation (GO:0097354)2.38132868
112protein prenylation (GO:0018342)2.38132868
113myeloid leukocyte mediated immunity (GO:0002444)2.36980393
114ventricular trabecula myocardium morphogenesis (GO:0003222)2.36824453
115regulation of amyloid precursor protein catabolic process (GO:1902991)2.36369371
116lens morphogenesis in camera-type eye (GO:0002089)2.36217151
117neurotransmitter-gated ion channel clustering (GO:0072578)2.35185057
118protein targeting to lysosome (GO:0006622)2.34286070
119establishment of protein localization to vacuole (GO:0072666)2.34286070
120protein targeting to vacuole (GO:0006623)2.34286070
121negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.33838288
122negative regulation of T-helper cell differentiation (GO:0045623)2.33838288
123positive regulation of gamma-delta T cell activation (GO:0046645)2.33739468
124response to epinephrine (GO:0071871)2.33705731
125iron ion import (GO:0097286)2.33417512
126lipid translocation (GO:0034204)2.32900162
127phospholipid translocation (GO:0045332)2.32900162
128clathrin coat assembly (GO:0048268)2.31977137
129coronary vasculature morphogenesis (GO:0060977)2.31415574
130myofibril assembly (GO:0030239)2.31372554
131positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.31359763
132import into cell (GO:0098657)2.30992667
133B cell receptor signaling pathway (GO:0050853)2.29116894
134epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.28659662
135positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.28481638
136interleukin-6-mediated signaling pathway (GO:0070102)2.28456139
137regulation of establishment or maintenance of cell polarity (GO:0032878)2.28271666
138collecting duct development (GO:0072044)2.28222657
139negative regulation of lymphocyte mediated immunity (GO:0002707)2.28158009
140detection of external biotic stimulus (GO:0098581)2.27738447
141intra-Golgi vesicle-mediated transport (GO:0006891)2.27488069
142neuron projection extension (GO:1990138)2.27182666
143negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.27114280
144sarcoplasmic reticulum calcium ion transport (GO:0070296)2.26113079
145presynaptic membrane assembly (GO:0097105)2.25696866
146negative regulation of B cell mediated immunity (GO:0002713)2.24845558
147negative regulation of immunoglobulin mediated immune response (GO:0002890)2.24845558
148regulation of platelet aggregation (GO:0090330)2.24814169
149peptidyl-lysine trimethylation (GO:0018023)2.24653655
150anatomical structure maturation (GO:0071695)2.24568071
151histone mRNA catabolic process (GO:0071044)2.24552292
152dendrite morphogenesis (GO:0048813)2.24534123
153regulation of dendritic spine morphogenesis (GO:0061001)2.21514752
154nerve growth factor signaling pathway (GO:0038180)2.21058253
155neutrophil activation (GO:0042119)2.20042422
156phospholipid homeostasis (GO:0055091)2.19866088
157central nervous system projection neuron axonogenesis (GO:0021952)2.19784836
158protein localization to Golgi apparatus (GO:0034067)2.18840661
159detection of calcium ion (GO:0005513)2.18620192
160response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.18556018
161response to host immune response (GO:0052572)2.18556018
162phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.18454218
163mechanoreceptor differentiation (GO:0042490)2.18432800
164embryonic viscerocranium morphogenesis (GO:0048703)2.17949970
165cochlea development (GO:0090102)2.17524676
166protein localization to synapse (GO:0035418)2.16767178
167cellular potassium ion homeostasis (GO:0030007)2.16249976
168stress granule assembly (GO:0034063)2.14736348
169mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.14689207
170positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.14665740
171vocalization behavior (GO:0071625)2.14245347
172activation of protein kinase A activity (GO:0034199)2.14074623
173heart valve formation (GO:0003188)2.14052508
174regulation of calcium ion-dependent exocytosis (GO:0017158)2.13836813
175establishment of nucleus localization (GO:0040023)2.13474192
176response to parathyroid hormone (GO:0071107)2.12856672
177I-kappaB phosphorylation (GO:0007252)2.12239743
178macrophage activation involved in immune response (GO:0002281)2.11560997
179myelin assembly (GO:0032288)2.11409000
180glutamate receptor signaling pathway (GO:0007215)2.08772359
181lipoprotein transport (GO:0042953)2.08619886
182regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.07219348
183sodium ion export (GO:0071436)2.06612876
184cardiac ventricle formation (GO:0003211)2.06545313
185regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.06427911
186neuronal stem cell maintenance (GO:0097150)2.04770786
187negative regulation of myoblast differentiation (GO:0045662)2.04430683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.22226806
2* GBX2_23144817_ChIP-Seq_PC3_Human3.13098564
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.82517866
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71095646
5DROSHA_22980978_ChIP-Seq_HELA_Human2.66901821
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.33406433
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29323740
8EZH2_22144423_ChIP-Seq_EOC_Human2.25789255
9TAF15_26573619_Chip-Seq_HEK293_Human2.24427517
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22813172
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10095644
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.01524244
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00379166
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91725778
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87885141
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87885141
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82581316
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81820463
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81219935
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77421300
21ER_23166858_ChIP-Seq_MCF-7_Human1.77229836
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.73563904
23REST_21632747_ChIP-Seq_MESCs_Mouse1.68157943
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.66998437
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65737802
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65634604
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65433046
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63084256
29* SPI1_23127762_ChIP-Seq_K562_Human1.60712985
30* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59882178
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59808559
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59449374
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58867316
34FUS_26573619_Chip-Seq_HEK293_Human1.58150094
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57459307
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56564600
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.56084206
38IGF1R_20145208_ChIP-Seq_DFB_Human1.54710346
39VDR_22108803_ChIP-Seq_LS180_Human1.54179049
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.52504043
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52450852
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51799738
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.50458859
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.49112130
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48661346
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48415844
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48371476
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47091323
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.46633410
50ZNF274_21170338_ChIP-Seq_K562_Hela1.46093443
51STAT3_23295773_ChIP-Seq_U87_Human1.45527758
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45480873
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44573837
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43830094
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43823689
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43321917
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43017201
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41490898
59* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41294670
60* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41294670
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.41105414
62BCAT_22108803_ChIP-Seq_LS180_Human1.40172267
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36397981
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36095105
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35404148
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34773367
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.33789416
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33278159
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32730782
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32275052
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.32233327
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.31544054
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30483329
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29489028
75P53_22387025_ChIP-Seq_ESCs_Mouse1.28665740
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28651488
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27794403
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.25176175
79* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24546622
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24494188
81* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24152678
82* FLI1_21867929_ChIP-Seq_TH2_Mouse1.23859031
83RUNX_20019798_ChIP-Seq_JUKART_Human1.23511757
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.23362209
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23198571
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23087108
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23087108
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.23086172
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22539748
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.22469644
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22106918
92SMAD3_21741376_ChIP-Seq_HESCs_Human1.21173157
93AR_21572438_ChIP-Seq_LNCaP_Human1.21046026
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19880027
95EWS_26573619_Chip-Seq_HEK293_Human1.19645877
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19326550
97CBP_20019798_ChIP-Seq_JUKART_Human1.19326550
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.18865678
99AR_19668381_ChIP-Seq_PC3_Human1.18731603
100* AR_25329375_ChIP-Seq_VCAP_Human1.17927533
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.17230686
102KDM2B_26808549_Chip-Seq_REH_Human1.16956878
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16476896
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16234085
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16149821
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15565653
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.15290770
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15058687
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.14741727
110TP53_16413492_ChIP-PET_HCT116_Human1.14417739
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13680289
112* TCF4_23295773_ChIP-Seq_U87_Human1.13460679
113* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12978049
114SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12579814
115TCF4_18268006_ChIP-ChIP_LS174T_Human1.12293004
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11481744
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10278539
118RXR_22108803_ChIP-Seq_LS180_Human1.09947425
119EZH2_27304074_Chip-Seq_ESCs_Mouse1.09471185
120STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08935186
121P300_18555785_Chip-Seq_ESCs_Mouse1.08522186
122* RUNX2_22187159_ChIP-Seq_PCA_Human1.08510641
123EP300_21415370_ChIP-Seq_HL-1_Mouse1.08359637
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07665089
125GATA1_22025678_ChIP-Seq_K562_Human1.07033551
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06758201
127RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06336596
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05927416
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05921083
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05684137
131KDM2B_26808549_Chip-Seq_K562_Human1.05483884
132EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05124115
133RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04704463
134MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04272866
135ARNT_22903824_ChIP-Seq_MCF-7_Human1.02852293
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02012470
137P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01909537
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01391527
139VDR_24787735_ChIP-Seq_THP-1_Human1.01139095
140KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01096299
141SMAD3_21741376_ChIP-Seq_ESCs_Human1.00117827
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99602779
143ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99525522
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.98593937
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98567324
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98494850
147CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96891839
148AHR_22903824_ChIP-Seq_MCF-7_Human0.96766979
149ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96765578
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96018538
151EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95819048
152NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95296854
153* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91760629
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89478833
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89459736
156SCL_19346495_ChIP-Seq_HPC-7_Human0.89037052
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87759256
158IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85997764
159PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84587384
160P300_19829295_ChIP-Seq_ESCs_Human0.84427452
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.83749240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.41343459
2MP0009780_abnormal_chondrocyte_physiolo6.21613744
3MP0003880_abnormal_central_pattern4.28726449
4MP0004859_abnormal_synaptic_plasticity3.75230088
5MP0005423_abnormal_somatic_nervous3.69217322
6MP0000566_synostosis3.57908779
7MP0003724_increased_susceptibility_to3.30652162
8MP0005257_abnormal_intraocular_pressure3.17830984
9MP0003183_abnormal_peptide_metabolism3.07069473
10MP0003172_abnormal_lysosome_physiology2.99341062
11MP0001958_emphysema2.56073503
12MP0005058_abnormal_lysosome_morphology2.46170942
13MP0002009_preneoplasia2.05155305
14MP0004510_myositis1.99520103
15MP0004036_abnormal_muscle_relaxation1.89804991
16MP0000015_abnormal_ear_pigmentation1.87163053
17MP0000427_abnormal_hair_cycle1.86524057
18MP0003787_abnormal_imprinting1.81084727
19MP0003283_abnormal_digestive_organ1.80799384
20MP0003635_abnormal_synaptic_transmissio1.80610496
21MP0003646_muscle_fatigue1.78843793
22MP0000371_diluted_coat_color1.76111379
23MP0003656_abnormal_erythrocyte_physiolo1.70142723
24MP0006054_spinal_hemorrhage1.70053867
25MP0005464_abnormal_platelet_physiology1.68801168
26MP0002332_abnormal_exercise_endurance1.67342318
27MP0003828_pulmonary_edema1.65997276
28MP0002089_abnormal_postnatal_growth/wei1.64276465
29MP0004858_abnormal_nervous_system1.60610618
30MP0003221_abnormal_cardiomyocyte_apopto1.60183916
31MP0002102_abnormal_ear_morphology1.59724911
32MP0002837_dystrophic_cardiac_calcinosis1.57618549
33MP0000749_muscle_degeneration1.55762731
34MP0008057_abnormal_DNA_replication1.53427178
35MP0005646_abnormal_pituitary_gland1.48365138
36MP0002063_abnormal_learning/memory/cond1.46694463
37MP0004145_abnormal_muscle_electrophysio1.44530798
38MP0002735_abnormal_chemical_nociception1.43213046
39MP0010386_abnormal_urinary_bladder1.42330589
40MP0002166_altered_tumor_susceptibility1.39810370
41MP0010030_abnormal_orbit_morphology1.38940628
42MP0001299_abnormal_eye_distance/1.38085885
43MP0008260_abnormal_autophagy1.31019087
44MP0002168_other_aberrant_phenotype1.30116265
45MP0005620_abnormal_muscle_contractility1.28683437
46MP0001968_abnormal_touch/_nociception1.28582225
47MP0002064_seizures1.27200638
48MP0010678_abnormal_skin_adnexa1.25900477
49MP0008569_lethality_at_weaning1.22536055
50MP0009745_abnormal_behavioral_response1.22326560
51MP0002972_abnormal_cardiac_muscle1.22204154
52MP0002736_abnormal_nociception_after1.21665125
53MP0003634_abnormal_glial_cell1.20877947
54MP0004270_analgesia1.19632151
55MP0003950_abnormal_plasma_membrane1.15256218
56MP0004233_abnormal_muscle_weight1.14272519
57MP0000383_abnormal_hair_follicle1.13805499
58MP0001984_abnormal_olfaction1.12209617
59MP0004134_abnormal_chest_morphology1.12189896
60MP0000955_abnormal_spinal_cord1.11789019
61MP0000465_gastrointestinal_hemorrhage1.10346815
62MP0000751_myopathy1.10337046
63MP0001486_abnormal_startle_reflex1.10305598
64MP0002909_abnormal_adrenal_gland1.09817178
65MP0003195_calcinosis1.08252681
66MP0004811_abnormal_neuron_physiology1.07155342
67MP0002127_abnormal_cardiovascular_syste1.06381337
68MP0004924_abnormal_behavior1.06120116
69MP0005386_behavior/neurological_phenoty1.06120116
70MP0002067_abnormal_sensory_capabilities1.03732721
71MP0009046_muscle_twitch1.02648995
72MP0002572_abnormal_emotion/affect_behav0.99396167
73MP0004885_abnormal_endolymph0.99028127
74MP0005174_abnormal_tail_pigmentation0.98827273
75MP0008775_abnormal_heart_ventricle0.98701041
76MP0004043_abnormal_pH_regulation0.98590190
77MP0003122_maternal_imprinting0.97941354
78MP0004883_abnormal_blood_vessel0.97066924
79MP0001188_hyperpigmentation0.97058214
80MP0002269_muscular_atrophy0.96911160
81MP0002106_abnormal_muscle_physiology0.96590772
82MP0000428_abnormal_craniofacial_morphol0.96420794
83MP0002733_abnormal_thermal_nociception0.96044856
84MP0005167_abnormal_blood-brain_barrier0.95983409
85MP0004381_abnormal_hair_follicle0.95240705
86MP0010234_abnormal_vibrissa_follicle0.94400368
87MP0003633_abnormal_nervous_system0.93766299
88MP0002998_abnormal_bone_remodeling0.93403549
89MP0001440_abnormal_grooming_behavior0.92917480
90MP0002734_abnormal_mechanical_nocicepti0.92835866
91MP0002075_abnormal_coat/hair_pigmentati0.90404319
92MP0001502_abnormal_circadian_rhythm0.90345242
93MP0005075_abnormal_melanosome_morpholog0.89395073
94MP0003091_abnormal_cell_migration0.88911705
95MP0001661_extended_life_span0.88446982
96MP0005171_absent_coat_pigmentation0.87911153
97MP0004087_abnormal_muscle_fiber0.87319192
98MP0010307_abnormal_tumor_latency0.87305635
99MP0009278_abnormal_bone_marrow0.86608690
100MP0008961_abnormal_basal_metabolism0.85841529
101MP0006276_abnormal_autonomic_nervous0.85716520
102MP0000778_abnormal_nervous_system0.84333155
103MP0000013_abnormal_adipose_tissue0.83641290
104MP0004085_abnormal_heartbeat0.82611462
105MP0004084_abnormal_cardiac_muscle0.82009144
106MP0003045_fibrosis0.81975285
107MP0001986_abnormal_taste_sensitivity0.81574558
108MP0001186_pigmentation_phenotype0.80393636
109MP0002184_abnormal_innervation0.80278537
110MP0001970_abnormal_pain_threshold0.80070795
111MP0005623_abnormal_meninges_morphology0.80037900
112MP0010630_abnormal_cardiac_muscle0.79748818
113MP0002006_tumorigenesis0.78575387
114MP0002882_abnormal_neuron_morphology0.77549230
115MP0005551_abnormal_eye_electrophysiolog0.75711291
116MP0002877_abnormal_melanocyte_morpholog0.75590335
117MP0003631_nervous_system_phenotype0.74534150
118MP0003137_abnormal_impulse_conducting0.74008259
119MP0004142_abnormal_muscle_tone0.73689321
120MP0005253_abnormal_eye_physiology0.71805933
121MP0002272_abnormal_nervous_system0.70593213
122MP0002971_abnormal_brown_adipose0.68970267
123MP0000920_abnormal_myelination0.68493511
124MP0005670_abnormal_white_adipose0.68434109
125MP0005369_muscle_phenotype0.68258263
126MP0003632_abnormal_nervous_system0.66494400
127MP0005310_abnormal_salivary_gland0.65292556
128MP0003690_abnormal_glial_cell0.64515889
129MP0002229_neurodegeneration0.64399267
130MP0001835_abnormal_antigen_presentation0.63830437
131MP0000003_abnormal_adipose_tissue0.63746341
132MP0002751_abnormal_autonomic_nervous0.61851792
133MP0003121_genomic_imprinting0.61156096
134MP0002557_abnormal_social/conspecific_i0.60501086
135MP0005645_abnormal_hypothalamus_physiol0.59235523
136MP0002638_abnormal_pupillary_reflex0.58420447
137MP0003300_gastrointestinal_ulcer0.58118566
138MP0004484_altered_response_of0.57442569
139MP0003279_aneurysm0.56921960
140MP0002066_abnormal_motor_capabilities/c0.55997997
141MP0004215_abnormal_myocardial_fiber0.55852988
142MP0001501_abnormal_sleep_pattern0.54639428
143MP0004808_abnormal_hematopoietic_stem0.54027807
144MP0002419_abnormal_innate_immunity0.53698736
145MP0001324_abnormal_eye_pigmentation0.53487425
146MP0008877_abnormal_DNA_methylation0.53381993
147MP0003329_amyloid_beta_deposits0.52862798
148MP0004130_abnormal_muscle_cell0.52198148
149MP0003303_peritoneal_inflammation0.51110458

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.44893762
2Neonatal short-limb short stature (HP:0008921)3.98232784
3Aplasia involving bones of the extremities (HP:0009825)3.64675910
4Aplasia involving bones of the upper limbs (HP:0009823)3.64675910
5Aplasia of the phalanges of the hand (HP:0009802)3.64675910
6Megalencephaly (HP:0001355)3.16569993
7Heterotopia (HP:0002282)3.13358806
8Alacrima (HP:0000522)3.00396037
9Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)3.00250723
10Increased cerebral lipofuscin (HP:0011813)3.00205820
11Abnormality of the lumbar spine (HP:0100712)2.92693116
12Visual hallucinations (HP:0002367)2.82137865
13Difficulty running (HP:0009046)2.80732615
14Leiomyosarcoma (HP:0100243)2.77861316
15Uterine leiomyosarcoma (HP:0002891)2.77861316
16Spinal canal stenosis (HP:0003416)2.75170232
17Abnormality of incisor morphology (HP:0011063)2.74816639
18Abnormality of the left ventricular outflow tract (HP:0011103)2.69994082
19Subaortic stenosis (HP:0001682)2.69994082
20Gaze-evoked nystagmus (HP:0000640)2.66562039
21Xerostomia (HP:0000217)2.62946618
22Gingival bleeding (HP:0000225)2.54293503
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.52904939
24Curly hair (HP:0002212)2.46857990
25T lymphocytopenia (HP:0005403)2.42089306
26Hematochezia (HP:0002573)2.41712117
27Decreased lacrimation (HP:0000633)2.41149022
28Spontaneous hematomas (HP:0007420)2.38399245
29Thyroid carcinoma (HP:0002890)2.35192682
30Febrile seizures (HP:0002373)2.34393668
31Focal motor seizures (HP:0011153)2.34243938
32Fair hair (HP:0002286)2.33722185
33Absent speech (HP:0001344)2.31964428
34Hyporeflexia of lower limbs (HP:0002600)2.30761826
35Hypoplastic ischia (HP:0003175)2.30712120
36Striae distensae (HP:0001065)2.29697637
37Vascular tortuosity (HP:0004948)2.28527110
38Abnormality of T cell number (HP:0011839)2.28294879
39Transitional cell carcinoma of the bladder (HP:0006740)2.28223242
40Supranuclear gaze palsy (HP:0000605)2.25332847
41Abnormality of the ischium (HP:0003174)2.24662101
42Prolonged bleeding time (HP:0003010)2.24462279
43Urinary bladder sphincter dysfunction (HP:0002839)2.24189642
44Hypochromic microcytic anemia (HP:0004840)2.23819910
45Recurrent corneal erosions (HP:0000495)2.23183394
46Renal cortical cysts (HP:0000803)2.22321979
47Nemaline bodies (HP:0003798)2.22159236
48Eczematoid dermatitis (HP:0000976)2.21538014
49Arterial thrombosis (HP:0004420)2.19929093
50Abnormality of the salivary glands (HP:0010286)2.18492339
51Inappropriate behavior (HP:0000719)2.18244293
52Aortic aneurysm (HP:0004942)2.17486931
53Abnormality of the right ventricle (HP:0001707)2.17405087
54Spondylolisthesis (HP:0003302)2.17343074
55Focal seizures (HP:0007359)2.17324323
56Abnormality of salivation (HP:0100755)2.15722694
57Broad-based gait (HP:0002136)2.14976531
58Adactyly (HP:0009776)2.13640173
59Absent frontal sinuses (HP:0002688)2.12844802
60Hip dysplasia (HP:0001385)2.12395874
61Cystic hygroma (HP:0000476)2.12143996
62Macroorchidism (HP:0000053)2.12127833
63Exercise-induced myalgia (HP:0003738)2.09433015
64Thickened helices (HP:0000391)2.09074024
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.08964795
66Protruding tongue (HP:0010808)2.08618849
67Muscle fiber inclusion bodies (HP:0100299)2.08520083
68Widely spaced teeth (HP:0000687)2.08414916
69Neoplasm of the tracheobronchial system (HP:0100552)2.08376671
70Termporal pattern (HP:0011008)2.08147266
71Insidious onset (HP:0003587)2.08147266
72Testicular neoplasm (HP:0010788)2.08062568
73Postural instability (HP:0002172)2.07078885
74Fetal akinesia sequence (HP:0001989)2.07037497
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.06888367
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06888367
77Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.06716566
78Frequent falls (HP:0002359)2.06479644
79Orchitis (HP:0100796)2.05722613
80Amyotrophic lateral sclerosis (HP:0007354)2.04250258
81Neurodegeneration (HP:0002180)2.03549185
82Dysostosis multiplex (HP:0000943)2.03495592
83Facial diplegia (HP:0001349)2.03291339
84Disinhibition (HP:0000734)2.01826320
85Long clavicles (HP:0000890)2.01823416
86Abnormality of the renal cortex (HP:0011035)2.00512151
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99924664
88Bladder carcinoma (HP:0002862)1.99859462
89Bladder neoplasm (HP:0009725)1.99859462
90Ocular albinism (HP:0001107)1.99768872
91Myositis (HP:0100614)1.99429327
92Mutism (HP:0002300)1.98812980
93Central scotoma (HP:0000603)1.98281958
94Menstrual irregularities (HP:0000858)1.98252979
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97857519
96Abnormality of the corticospinal tract (HP:0002492)1.97677917
97Bundle branch block (HP:0011710)1.96511526
98Lower limb muscle weakness (HP:0007340)1.95995775
99Tubulointerstitial nephritis (HP:0001970)1.95815652
100Generalized hypopigmentation of hair (HP:0011358)1.95695842
101Calf muscle hypertrophy (HP:0008981)1.94566993
102Germ cell neoplasia (HP:0100728)1.94520602
103Urethral obstruction (HP:0000796)1.94131957
104Abnormality of the calf musculature (HP:0001430)1.92791198
105Excessive salivation (HP:0003781)1.92110731
106Drooling (HP:0002307)1.92110731
107Abnormality of the costochondral junction (HP:0000919)1.91321050
108Intellectual disability, profound (HP:0002187)1.91095810
109Impaired vibratory sensation (HP:0002495)1.91029917
110Distal arthrogryposis (HP:0005684)1.90981411
111Chest pain (HP:0100749)1.90921329
112Hemiplegia (HP:0002301)1.89879525
113Truncal obesity (HP:0001956)1.88874507
114Genetic anticipation (HP:0003743)1.88644257
115Arterial tortuosity (HP:0005116)1.88259254
116Stomatitis (HP:0010280)1.88251027
117Neoplasm of the adrenal cortex (HP:0100641)1.87317331
118Depression (HP:0000716)1.87097594
119Thyroiditis (HP:0100646)1.85098915
120Abnormality of glycolipid metabolism (HP:0010969)1.84913776
121Abnormality of liposaccharide metabolism (HP:0010968)1.84913776
122Abnormality of glycosphingolipid metabolism (HP:0004343)1.84913776
123Medial flaring of the eyebrow (HP:0010747)1.84800860
124Recurrent skin infections (HP:0001581)1.84328238
125Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.83628842
126Aqueductal stenosis (HP:0002410)1.83453314
127Muscle hypertrophy of the lower extremities (HP:0008968)1.83383642
128Keratoconjunctivitis sicca (HP:0001097)1.83081338
129Hyperlipoproteinemia (HP:0010980)1.82434909
130Neonatal death (HP:0003811)1.81856850
131Iris hypopigmentation (HP:0007730)1.81078911
132Subacute progressive viral hepatitis (HP:0006572)1.80892845
133Recurrent abscess formation (HP:0002722)1.80315703
134Cerebral aneurysm (HP:0004944)1.79751127
135Coronal craniosynostosis (HP:0004440)1.79342723
136Progressive inability to walk (HP:0002505)1.79262295
137Recurrent bacterial skin infections (HP:0005406)1.78992123
138Keratoconjunctivitis (HP:0001096)1.78671841
139Gait imbalance (HP:0002141)1.78463131
140Atonic seizures (HP:0010819)1.77793132
141Progressive sensorineural hearing impairment (HP:0000408)1.77444731
142EMG: neuropathic changes (HP:0003445)1.76507104
143Abnormality of the antihelix (HP:0009738)1.75713884
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75518169
145Epileptic encephalopathy (HP:0200134)1.74984380
146Progressive cerebellar ataxia (HP:0002073)1.73147783
147Optic neuritis (HP:0100653)1.73098405
148Retrobulbar optic neuritis (HP:0100654)1.73098405
149Sudden death (HP:0001699)1.73044991
150Hand muscle atrophy (HP:0009130)1.72934180
151Gingivitis (HP:0000230)1.72649251
152Gastrointestinal infarctions (HP:0005244)1.71625501
153Action tremor (HP:0002345)1.71398321
154Infantile muscular hypotonia (HP:0008947)1.70819626
155Partial duplication of thumb phalanx (HP:0009944)1.69261711
156Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68670957
157Abnormality of polysaccharide metabolism (HP:0011012)1.68670957
158Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68670957
159Albinism (HP:0001022)1.68606354
160Mixed hearing impairment (HP:0000410)1.68191700
161Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66729582
162Congenital primary aphakia (HP:0007707)1.66548968
163Syncope (HP:0001279)1.66212978
164Abnormality of the epiphyses of the hand (HP:0005924)1.66184848
165Muscle fiber splitting (HP:0003555)1.66119016
166Inability to walk (HP:0002540)1.65655359
167Dialeptic seizures (HP:0011146)1.65480810
168Papillary thyroid carcinoma (HP:0002895)1.65042795
169Abnormality of the musculature of the pelvis (HP:0001469)1.64587598
170Apathy (HP:0000741)1.63827670
171Abnormality of macular pigmentation (HP:0008002)1.62485025
172Asymmetric septal hypertrophy (HP:0001670)1.60985134
173Conical tooth (HP:0000698)1.60581363
174Flared metaphyses (HP:0003015)1.60578733
175Diminished motivation (HP:0000745)1.59579700
176Choroideremia (HP:0001139)1.59400563
177Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.57975822
178Agitation (HP:0000713)1.56921873
179Spinal muscular atrophy (HP:0007269)1.56688079
180Papilledema (HP:0001085)1.56345356
181Diplopia (HP:0000651)1.55765982
182Abnormality of binocular vision (HP:0011514)1.55765982
183Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.55536916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.24280003
2FGFR33.81089221
3BUB13.39676161
4MARK12.70027807
5PRKD32.65119228
6OBSCN2.31313748
7NTRK32.28976635
8CAMK1D2.20564123
9ACVR1B2.13310112
10SGK21.96607901
11SGK2231.90144503
12SGK4941.90144503
13TAOK31.87047745
14SCYL21.86673582
15SGK31.80999078
16PRKCH1.80809938
17DAPK21.78169997
18BLK1.75009068
19FGR1.74473882
20EPHA31.74451800
21WNK31.70032784
22RIPK41.68105265
23PIK3CG1.67508283
24PAK61.65435450
25CAMK1G1.64917673
26TNIK1.62101029
27CAMKK11.61255170
28JAK11.57611699
29MAP2K71.57056944
30MAP3K131.54001474
31FGFR21.53253811
32SIK21.52738766
33MAP3K141.51284732
34MAP2K41.47825949
35PAK31.46766321
36MAP3K41.46376100
37FGFR11.43652597
38TEC1.39734220
39NEK61.38381540
40CCNB11.37905492
41PTK2B1.35196049
42AKT31.33049290
43PRPF4B1.32863099
44TXK1.27625267
45CAMKK21.22903299
46CDK81.21428197
47SGK11.19422191
48NTRK11.18615818
49MINK11.11630690
50MAP4K21.08306530
51MAP2K31.07155405
52PINK11.04245137
53STK381.04059000
54CDC42BPA1.03592158
55CDK51.03571331
56BCR1.02764447
57BTK1.00548888
58KIT0.99689131
59BRD40.99498878
60MAP3K90.99216016
61YES10.98861043
62BMX0.98606123
63FER0.97108946
64OXSR10.96526268
65NTRK20.95592152
66MAP3K70.95276308
67CSF1R0.93857123
68JAK20.93267603
69ALK0.92880377
70TRPM70.92661082
71ERBB30.92167785
72CAMK40.90310771
73TGFBR20.89932541
74DAPK10.88877477
75TNK20.88490410
76ZAK0.88421558
77TTN0.88287071
78RIPK10.87413089
79PDGFRA0.86484972
80WNK10.86220568
81IRAK10.85445111
82STK110.85092886
83MAPK100.84546594
84SYK0.84181893
85PKN20.83988338
86PDK10.83911418
87KSR10.82816597
88NEK90.80420616
89DMPK0.79690512
90TRIB30.79401498
91BMPR20.79226970
92MELK0.77826460
93MAP3K20.77735661
94PRKCE0.76279608
95PRKCZ0.76048883
96PRKAA10.74945715
97ITK0.74830100
98JAK30.73107320
99FES0.73016732
100NLK0.72846598
101RET0.72257979
102PRKCG0.71174699
103PLK20.71152387
104CSK0.70813887
105MAPK130.70093873
106EPHA40.69115511
107PDGFRB0.68313128
108DYRK1A0.67526703
109CDK120.67208196
110BMPR1B0.66733945
111CHUK0.66007827
112MAP3K60.64533678
113PHKG20.63877420
114PHKG10.63877420
115MARK30.63567188
116ROCK10.63404068
117CASK0.62385024
118LMTK20.61462065
119PRKAA20.60987304
120MAP3K50.60957236
121IKBKE0.58797239
122RPS6KB10.58714872
123LYN0.56792742
124MTOR0.56593112
125NEK20.55683699
126IRAK40.53910107
127TIE10.53621491
128CDK90.53044467
129RPS6KA30.52667453
130LCK0.52437950
131TRIM280.51670486
132EPHB10.51563206
133PDPK10.50882701
134CAMK10.49376133
135INSRR0.49248002
136PIK3CA0.48650453
137MARK20.48576027
138PRKCB0.48080307
139IGF1R0.47798045
140RPS6KA20.46933346
141PKN10.46830603
142GRK60.46786507
143ICK0.46673090
144TYK20.46064679
145NUAK10.46041961
146FYN0.46014425
147RAF10.45671746
148ERBB20.45527103
149MAPK90.45326601
150MAPK120.45188545
151MKNK20.45076459
152ADRBK10.44834296
153AKT20.43079918
154UHMK10.42313608
155TAOK10.41985830
156BRSK10.40196764
157PTK60.39479106
158HCK0.38830700

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.26519274
2Type II diabetes mellitus_Homo sapiens_hsa049301.90228287
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68241142
4Insulin secretion_Homo sapiens_hsa049111.66450163
5Circadian entrainment_Homo sapiens_hsa047131.65785916
6Olfactory transduction_Homo sapiens_hsa047401.60706181
7Morphine addiction_Homo sapiens_hsa050321.54696140
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52531188
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51683890
10Regulation of autophagy_Homo sapiens_hsa041401.49257743
11Lysosome_Homo sapiens_hsa041421.47931846
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44713301
13Nicotine addiction_Homo sapiens_hsa050331.43251824
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33996886
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.31613796
16Glutamatergic synapse_Homo sapiens_hsa047241.30518181
17Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26057102
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26011829
19Long-term potentiation_Homo sapiens_hsa047201.24657571
20Collecting duct acid secretion_Homo sapiens_hsa049661.23538652
21Dorso-ventral axis formation_Homo sapiens_hsa043201.22232361
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22065282
23Cholinergic synapse_Homo sapiens_hsa047251.21489872
24GABAergic synapse_Homo sapiens_hsa047271.20748881
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20653944
26Non-small cell lung cancer_Homo sapiens_hsa052231.19947653
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19081585
28ABC transporters_Homo sapiens_hsa020101.18452061
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17831550
30Inositol phosphate metabolism_Homo sapiens_hsa005621.15086154
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12140619
32Notch signaling pathway_Homo sapiens_hsa043301.10443068
33Salivary secretion_Homo sapiens_hsa049701.08909267
34Dopaminergic synapse_Homo sapiens_hsa047281.07123540
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05443149
36mTOR signaling pathway_Homo sapiens_hsa041501.04733980
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04498418
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04358202
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02116526
40Dilated cardiomyopathy_Homo sapiens_hsa054141.01004666
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.99395152
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99060309
43Oxytocin signaling pathway_Homo sapiens_hsa049210.98256086
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97689936
45cAMP signaling pathway_Homo sapiens_hsa040240.97564991
46Renin secretion_Homo sapiens_hsa049240.96773682
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.94920255
48T cell receptor signaling pathway_Homo sapiens_hsa046600.93707272
49Glioma_Homo sapiens_hsa052140.92655209
50Calcium signaling pathway_Homo sapiens_hsa040200.92546153
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92108438
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91601183
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90769925
54Renal cell carcinoma_Homo sapiens_hsa052110.90152496
55Amphetamine addiction_Homo sapiens_hsa050310.90060625
56Taste transduction_Homo sapiens_hsa047420.88506402
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88350726
58Fatty acid biosynthesis_Homo sapiens_hsa000610.86421463
59Osteoclast differentiation_Homo sapiens_hsa043800.85989636
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.85720434
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85527258
62Chemokine signaling pathway_Homo sapiens_hsa040620.85393152
63Gastric acid secretion_Homo sapiens_hsa049710.85024141
64Endocytosis_Homo sapiens_hsa041440.84150280
65Leishmaniasis_Homo sapiens_hsa051400.82795365
66Vibrio cholerae infection_Homo sapiens_hsa051100.82780573
67Circadian rhythm_Homo sapiens_hsa047100.80496199
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79769540
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.79741603
70Measles_Homo sapiens_hsa051620.79677961
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79588818
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.78564008
73Phototransduction_Homo sapiens_hsa047440.78402192
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78394521
75Phagosome_Homo sapiens_hsa041450.77573907
76Ether lipid metabolism_Homo sapiens_hsa005650.77335430
77Rheumatoid arthritis_Homo sapiens_hsa053230.76806294
78Platelet activation_Homo sapiens_hsa046110.75894627
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75577383
80Long-term depression_Homo sapiens_hsa047300.75266149
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.75110844
82Tuberculosis_Homo sapiens_hsa051520.74510010
83Chronic myeloid leukemia_Homo sapiens_hsa052200.74134619
84TNF signaling pathway_Homo sapiens_hsa046680.73641557
85Choline metabolism in cancer_Homo sapiens_hsa052310.72283346
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72276332
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71908895
88Cocaine addiction_Homo sapiens_hsa050300.71606370
89Type I diabetes mellitus_Homo sapiens_hsa049400.71380062
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71163221
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70576466
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70469833
93Estrogen signaling pathway_Homo sapiens_hsa049150.70168700
94ErbB signaling pathway_Homo sapiens_hsa040120.69937188
95B cell receptor signaling pathway_Homo sapiens_hsa046620.69718454
96Colorectal cancer_Homo sapiens_hsa052100.69521149
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68683202
98MAPK signaling pathway_Homo sapiens_hsa040100.68361092
99Nitrogen metabolism_Homo sapiens_hsa009100.68183401
100Rap1 signaling pathway_Homo sapiens_hsa040150.68050907
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67536230
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66812414
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66650645
104MicroRNAs in cancer_Homo sapiens_hsa052060.66270890
105Insulin resistance_Homo sapiens_hsa049310.65730058
106GnRH signaling pathway_Homo sapiens_hsa049120.65701195
107Focal adhesion_Homo sapiens_hsa045100.65222306
108Insulin signaling pathway_Homo sapiens_hsa049100.64212746
109Proteoglycans in cancer_Homo sapiens_hsa052050.63970548
110Prolactin signaling pathway_Homo sapiens_hsa049170.63262301
111Sphingolipid metabolism_Homo sapiens_hsa006000.62983876
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.62699897
113Pancreatic cancer_Homo sapiens_hsa052120.61926389
114Hedgehog signaling pathway_Homo sapiens_hsa043400.61781208
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61183338
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.60577492
117Non-homologous end-joining_Homo sapiens_hsa034500.60416519
118Endometrial cancer_Homo sapiens_hsa052130.59907061
119Axon guidance_Homo sapiens_hsa043600.59818628
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59804738
121Gap junction_Homo sapiens_hsa045400.59145513
122Acute myeloid leukemia_Homo sapiens_hsa052210.58918421
123Serotonergic synapse_Homo sapiens_hsa047260.58743477
124Melanogenesis_Homo sapiens_hsa049160.58535005
125Ras signaling pathway_Homo sapiens_hsa040140.57721919
126FoxO signaling pathway_Homo sapiens_hsa040680.57560796
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57394907
128Glucagon signaling pathway_Homo sapiens_hsa049220.57134925
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56794583

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