VPS9D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.57441350
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.57441350
3response to peptidoglycan (GO:0032494)4.47617948
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.41217646
5vocalization behavior (GO:0071625)4.36743457
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.30852685
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30550521
8macrophage activation involved in immune response (GO:0002281)4.27497838
9modulation by symbiont of host defense response (GO:0052031)4.18987937
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18987937
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18987937
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.18987937
13modulation by symbiont of host immune response (GO:0052553)4.18987937
14positive regulation by symbiont of host defense response (GO:0052509)4.18987937
15neuron cell-cell adhesion (GO:0007158)4.18207051
16regulation of glutamate receptor signaling pathway (GO:1900449)3.98419541
17leukocyte aggregation (GO:0070486)3.97219168
18regulation of synapse structural plasticity (GO:0051823)3.95561408
19negative regulation of interleukin-12 production (GO:0032695)3.94971548
20protein localization to synapse (GO:0035418)3.93847676
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92276772
22neurotransmitter-gated ion channel clustering (GO:0072578)3.91296125
23negative regulation of erythrocyte differentiation (GO:0045647)3.90949225
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.90131115
25synaptic vesicle exocytosis (GO:0016079)3.86299510
26glutamate secretion (GO:0014047)3.84344393
27synaptic vesicle maturation (GO:0016188)3.82620108
28positive regulation of gamma-delta T cell activation (GO:0046645)3.79940367
29detection of other organism (GO:0098543)3.77215260
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76911807
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.76545824
32mannose metabolic process (GO:0006013)3.70061614
33regulation of synaptic vesicle exocytosis (GO:2000300)3.70025226
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69474582
35antigen processing and presentation of endogenous antigen (GO:0019883)3.68545382
36neutrophil activation involved in immune response (GO:0002283)3.68223390
37detection of bacterium (GO:0016045)3.66176049
38germinal center formation (GO:0002467)3.65169439
39synaptic vesicle docking involved in exocytosis (GO:0016081)3.61655497
40locomotory exploration behavior (GO:0035641)3.58060279
41regulation of synaptic vesicle transport (GO:1902803)3.56820159
42detection of molecule of bacterial origin (GO:0032490)3.55424079
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.54126388
44regulation of interferon-beta biosynthetic process (GO:0045357)3.52433664
45positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.50083221
46regulation of T-helper 2 cell differentiation (GO:0045628)3.50052004
47response to muramyl dipeptide (GO:0032495)3.48504106
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47063502
49detection of external biotic stimulus (GO:0098581)3.42363651
50response to type I interferon (GO:0034340)3.41678945
51cellular response to type I interferon (GO:0071357)3.38302919
52type I interferon signaling pathway (GO:0060337)3.38302919
53neuronal action potential propagation (GO:0019227)3.34740967
54synaptic transmission, glutamatergic (GO:0035249)3.32645375
55glutamate receptor signaling pathway (GO:0007215)3.31845026
56postsynaptic membrane organization (GO:0001941)3.28422946
57immunoglobulin mediated immune response (GO:0016064)3.27203866
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.26748945
59dendritic spine morphogenesis (GO:0060997)3.26420715
60lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24064713
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22361277
62regulation of mast cell degranulation (GO:0043304)3.22020833
63synaptic vesicle endocytosis (GO:0048488)3.21135391
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19665043
65regulation of neuronal synaptic plasticity (GO:0048168)3.18966729
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16506054
67leukocyte migration involved in inflammatory response (GO:0002523)3.15897577
68regulation of myeloid leukocyte mediated immunity (GO:0002886)3.14542004
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.13585582
70neurotransmitter secretion (GO:0007269)3.10610115
71neuron recognition (GO:0008038)3.07699484
72detection of biotic stimulus (GO:0009595)3.07196154
73negative regulation of cytokine production involved in immune response (GO:0002719)3.06326433
74regulation of leukocyte degranulation (GO:0043300)3.06105805
75regulation of postsynaptic membrane potential (GO:0060078)3.05308653
76NIK/NF-kappaB signaling (GO:0038061)3.03913840
77neuron-neuron synaptic transmission (GO:0007270)3.01376830
78membrane depolarization during action potential (GO:0086010)3.00440194
79negative regulation of lymphocyte mediated immunity (GO:0002707)2.99625688
80cerebellar Purkinje cell differentiation (GO:0021702)2.98279270
81defense response to protozoan (GO:0042832)2.98161718
82exploration behavior (GO:0035640)2.97790988
83regulation of long-term neuronal synaptic plasticity (GO:0048169)2.97597411
84presynaptic membrane assembly (GO:0097105)2.97487140
85positive regulation of membrane potential (GO:0045838)2.96026140
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.94782860
87negative regulation of leukocyte mediated immunity (GO:0002704)2.93954677
88macrophage activation (GO:0042116)2.93258915
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91753196
90neuronal ion channel clustering (GO:0045161)2.91449324
91pyrimidine nucleobase catabolic process (GO:0006208)2.91166025
92regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90862518
93positive regulation of type 2 immune response (GO:0002830)2.90827595
94membrane depolarization (GO:0051899)2.90357237
95regulation of gamma-delta T cell activation (GO:0046643)2.89016113
96regulation of regulated secretory pathway (GO:1903305)2.88293747
97myeloid cell activation involved in immune response (GO:0002275)2.86806953
98granulocyte activation (GO:0036230)2.85783460
99layer formation in cerebral cortex (GO:0021819)2.85598270
100negative regulation of innate immune response (GO:0045824)2.84421271
101response to pheromone (GO:0019236)2.84250409
102interferon-gamma-mediated signaling pathway (GO:0060333)2.82236103
103adenosine receptor signaling pathway (GO:0001973)2.82113874
104negative regulation of toll-like receptor signaling pathway (GO:0034122)2.81044127
105neutrophil activation (GO:0042119)2.80488742
106long-term memory (GO:0007616)2.80137864
107regulation of mast cell activation involved in immune response (GO:0033006)2.79586518
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78729642
109dendrite morphogenesis (GO:0048813)2.77301312
110regulation of type 2 immune response (GO:0002828)2.76677778
111regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.76428370
112regulation of vesicle fusion (GO:0031338)2.74622105
113response to protozoan (GO:0001562)2.73656201
114regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73491003
115positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.72534033
116negative regulation of T cell mediated immunity (GO:0002710)2.71027024
117response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70455910
118response to host immune response (GO:0052572)2.70455910
119presynaptic membrane organization (GO:0097090)2.70190057
120negative regulation of type 2 immune response (GO:0002829)2.69042759
121gamma-aminobutyric acid signaling pathway (GO:0007214)2.67518982
122regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67072723
123negative regulation of interleukin-6 production (GO:0032715)2.66386441
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.64969786
125response to auditory stimulus (GO:0010996)2.64688499
126prepulse inhibition (GO:0060134)2.64089027
127regulation of toll-like receptor signaling pathway (GO:0034121)2.63698939
128axonal fasciculation (GO:0007413)2.63613436
129negative regulation of tumor necrosis factor production (GO:0032720)2.63477158
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63398407
131gamma-aminobutyric acid transport (GO:0015812)2.61440436
132negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.60289827
133central nervous system projection neuron axonogenesis (GO:0021952)2.59320826
134auditory behavior (GO:0031223)2.58979532
135synapse assembly (GO:0007416)2.57705511
136cellular extravasation (GO:0045123)2.57367207
137negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.55683980
138regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.55593249
139positive thymic T cell selection (GO:0045059)2.55508311
140response to host (GO:0075136)2.55372247
141response to host defenses (GO:0052200)2.55372247
142response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.55372247
143regulation of synaptic transmission, GABAergic (GO:0032228)2.54960041
144calcium ion import (GO:0070509)2.52555489
145regulation of synaptic plasticity (GO:0048167)2.52269331
146tolerance induction (GO:0002507)2.51567394
147respiratory burst (GO:0045730)2.51117377
148regulation of T cell tolerance induction (GO:0002664)2.50955526
149signal complex assembly (GO:0007172)2.50701569
150regulation of interferon-alpha production (GO:0032647)2.50084992
151neurotransmitter transport (GO:0006836)2.49541297
152nucleobase catabolic process (GO:0046113)2.49512211
153positive regulation of neurotransmitter secretion (GO:0001956)2.49162812
154negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.48884357
155myeloid dendritic cell differentiation (GO:0043011)2.48820824
156regulation of neurotransmitter secretion (GO:0046928)2.48550714
157transmission of nerve impulse (GO:0019226)2.47708246
158positive regulation of Cdc42 GTPase activity (GO:0043089)2.47278891
159positive regulation of antigen processing and presentation (GO:0002579)2.47273726
160glycine transport (GO:0015816)2.46838923
161regulation of antigen processing and presentation (GO:0002577)2.45914238
162negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.45732677
163learning (GO:0007612)2.45674951
164T-helper 1 type immune response (GO:0042088)2.44478318
165positive regulation of protein dephosphorylation (GO:0035307)2.44042537
166regulation of ARF protein signal transduction (GO:0032012)2.43272436
167striatum development (GO:0021756)2.42370920
168positive regulation of interferon-alpha production (GO:0032727)2.41868630
169mechanosensory behavior (GO:0007638)2.41364940
170regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.40562629
171long-term synaptic potentiation (GO:0060291)2.40464319
172response to manganese ion (GO:0010042)2.40218694
173negative regulation of production of molecular mediator of immune response (GO:0002701)2.40063335
174negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38601426
175microglial cell activation (GO:0001774)2.37455208
176regulation of mast cell activation (GO:0033003)2.37344822
177cell communication by electrical coupling (GO:0010644)2.37044361
178positive regulation of synapse assembly (GO:0051965)2.35999355
179visual learning (GO:0008542)2.33564302
180positive regulation of neurotransmitter transport (GO:0051590)2.31626249
181regulation of neurotransmitter transport (GO:0051588)2.31181953
182positive regulation of dendritic spine development (GO:0060999)2.30887057
183regulation of neurotransmitter levels (GO:0001505)2.30440605
184regulation of ARF GTPase activity (GO:0032312)2.30326154
185adult walking behavior (GO:0007628)2.29867068
186phosphorelay signal transduction system (GO:0000160)2.29397872
187detection of calcium ion (GO:0005513)2.28433066
188activation of protein kinase A activity (GO:0034199)2.28182007
189membrane hyperpolarization (GO:0060081)2.27779661
190neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.27376222
191positive regulation of synaptic transmission (GO:0050806)2.27373042
192regulation of synapse maturation (GO:0090128)2.27043740
193dopamine receptor signaling pathway (GO:0007212)2.26999468
194proline transport (GO:0015824)2.26950119
195cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.25935316
196cAMP-mediated signaling (GO:0019933)2.25458130
197dendritic spine organization (GO:0097061)2.24436941
198establishment of synaptic vesicle localization (GO:0097480)2.24365542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57971055
2GBX2_23144817_ChIP-Seq_PC3_Human3.55899764
3VDR_21846776_ChIP-Seq_THP-1_Human3.14515538
4LXR_22292898_ChIP-Seq_THP-1_Human2.91315610
5DROSHA_22980978_ChIP-Seq_HELA_Human2.89570132
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.75709169
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.69349641
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58694470
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55992014
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47366773
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32890495
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29743901
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29570271
14KDM2B_26808549_Chip-Seq_DND41_Human2.27624004
15REST_21632747_ChIP-Seq_MESCs_Mouse2.25238575
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.23181733
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.21947635
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21886915
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21886915
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21695479
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18806235
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.17926495
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17660575
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16835541
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.16802358
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15503189
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13970169
28RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12698697
29VDR_24763502_ChIP-Seq_THP-1_Human2.10676600
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09318033
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.00967238
32MYC_22102868_ChIP-Seq_BL_Human1.99320121
33P68_20966046_ChIP-Seq_HELA_Human1.99295416
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97688492
35TCF7_22412390_ChIP-Seq_EML_Mouse1.97317270
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96887466
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.96325232
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96093975
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95149850
40RACK7_27058665_Chip-Seq_MCF-7_Human1.93738118
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92093855
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91574417
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.90789056
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89464861
45MAF_26560356_Chip-Seq_TH1_Human1.87814545
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.87115106
47MAF_26560356_Chip-Seq_TH2_Human1.84325587
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83800388
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.81219754
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80981555
51BCL6_27268052_Chip-Seq_Bcells_Human1.73361364
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.72499272
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69885027
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69835711
55BCOR_27268052_Chip-Seq_Bcells_Human1.68867773
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.68535402
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.67547665
58UTX_26944678_Chip-Seq_JUKART_Human1.67110371
59SMC4_20622854_ChIP-Seq_HELA_Human1.65039414
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65017184
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64148138
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62517887
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.58009079
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.57208629
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55564887
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55060092
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53737681
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53376067
69SPI1_23127762_ChIP-Seq_K562_Human1.52755820
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.52472395
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52057498
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.50834729
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.49146944
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48482551
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48275015
76TAF15_26573619_Chip-Seq_HEK293_Human1.47346864
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46871571
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46705735
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45422647
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44320512
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41625653
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41479308
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.40046647
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39548458
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38511489
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.34081714
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33105566
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32213748
89CREB1_26743006_Chip-Seq_LNCaP_Human1.31249036
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31117866
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30449695
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28014350
93SMAD4_21799915_ChIP-Seq_A2780_Human1.27797849
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27713735
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27644970
96E2F1_20622854_ChIP-Seq_HELA_Human1.26750409
97SA1_27219007_Chip-Seq_Bcells_Human1.26233066
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26104898
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26066752
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25704773
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25120476
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24480948
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24392995
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24205728
105BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21403270
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21351812
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19661769
108PHF8_20622854_ChIP-Seq_HELA_Human1.17096236
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16962938
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16351572
111SPI1_23547873_ChIP-Seq_NB4_Human1.16305745
112SCL_19346495_ChIP-Seq_HPC-7_Human1.15445900
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15287256
114CTCF_26484167_Chip-Seq_Bcells_Mouse1.14480851
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14324675
116RARB_24833708_ChIP-Seq_LIVER_Mouse1.14246400
117TP63_17297297_ChIP-ChIP_HaCaT_Human1.13606529
118CTCF_20526341_ChIP-Seq_ESCs_Human1.13314768
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13109306
120AR_21572438_ChIP-Seq_LNCaP_Human1.13048920
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13007757
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12443155
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12395098
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12229839
125CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11210531
126P300_19829295_ChIP-Seq_ESCs_Human1.11174831
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.10926088
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09874608
129P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09123447
130IGF1R_20145208_ChIP-Seq_DFB_Human1.09032545
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08205277
132CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07102336
133TP63_22573176_ChIP-Seq_HFKS_Human1.06478539
134NCOR1_26117541_ChIP-Seq_K562_Human1.05992848
135AR_25329375_ChIP-Seq_VCAP_Human1.04797630
136SOX2_21211035_ChIP-Seq_LN229_Gbm1.04661047
137SMAD3_21741376_ChIP-Seq_EPCs_Human1.04623761
138OCT4_19829295_ChIP-Seq_ESCs_Human1.03442298
139MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02908422
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02609981
141CTCF_21964334_Chip-Seq_Bcells_Human1.02402296
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02086929
143* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01668879
144PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01488764
145BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01093580
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00216320
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00138059
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98539683
149TCF4_23295773_ChIP-Seq_U87_Human0.97319476
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.96578770
151STAT3_23295773_ChIP-Seq_U87_Human0.95846155
152AR_19668381_ChIP-Seq_PC3_Human0.93810341
153CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93359773
154RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92651219
155CTCF_27219007_Chip-Seq_Bcells_Human0.92273700
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90541461
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90541461
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.89740456
159LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89706156
160PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89071821
161AHR_22903824_ChIP-Seq_MCF-7_Human0.88994750
162RNF2_27304074_Chip-Seq_NSC_Mouse0.88742054
163NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87770484
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86778245
165KDM2B_26808549_Chip-Seq_K562_Human0.85932385
166NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85428402
167EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85365446
168RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85237647
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.84300319
170RING1B_27294783_Chip-Seq_NPCs_Mouse0.83738628
171KDM2B_26808549_Chip-Seq_REH_Human0.83642914
172NANOG_18555785_Chip-Seq_ESCs_Mouse0.83058894
173POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83052978
174RUNX2_22187159_ChIP-Seq_PCA_Human0.82482577
175SMAD4_21741376_ChIP-Seq_HESCs_Human0.82458602
176SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81761502
177P53_22387025_ChIP-Seq_ESCs_Mouse0.80905851
178ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80855793
179ZNF274_21170338_ChIP-Seq_K562_Hela0.80249351
180OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79853022
181TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79705380
182BCAT_22108803_ChIP-Seq_LS180_Human0.79379697
183EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79282203
184SMAD3_21741376_ChIP-Seq_HESCs_Human0.78579887
185UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78545942
186PRDM14_20953172_ChIP-Seq_ESCs_Human0.78375330
187CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78355734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.34684575
2MP0003303_peritoneal_inflammation4.26973138
3MP0003436_decreased_susceptibility_to4.15046263
4MP0003880_abnormal_central_pattern4.05830354
5MP0003724_increased_susceptibility_to4.05755564
6MP0003635_abnormal_synaptic_transmissio3.45629293
7MP0005058_abnormal_lysosome_morphology3.20942062
8MP0009745_abnormal_behavioral_response2.96735924
9MP0002063_abnormal_learning/memory/cond2.82411033
10MP0002064_seizures2.65817229
11MP0005423_abnormal_somatic_nervous2.61818303
12MP0002419_abnormal_innate_immunity2.59418800
13MP0001984_abnormal_olfaction2.57381974
14MP0006082_CNS_inflammation2.52386125
15MP0002572_abnormal_emotion/affect_behav2.50321260
16MP0004270_analgesia2.49900980
17MP0005025_abnormal_response_to2.48280738
18MP0001968_abnormal_touch/_nociception2.46652595
19MP0001835_abnormal_antigen_presentation2.42861442
20MP0009785_altered_susceptibility_to2.41304765
21MP0009278_abnormal_bone_marrow2.33903864
22MP0009046_muscle_twitch2.33473451
23MP0005387_immune_system_phenotype2.27079300
24MP0001790_abnormal_immune_system2.27079300
25MP0005645_abnormal_hypothalamus_physiol2.26890934
26MP0005000_abnormal_immune_tolerance2.26249524
27MP0001533_abnormal_skeleton_physiology2.21865122
28MP0001486_abnormal_startle_reflex2.18617985
29MP0002148_abnormal_hypersensitivity_rea2.14846349
30MP0005646_abnormal_pituitary_gland2.14453596
31MP0002272_abnormal_nervous_system2.12253485
32MP0009840_abnormal_foam_cell2.11344039
33MP0001440_abnormal_grooming_behavior2.08088519
34MP0000569_abnormal_digit_pigmentation2.07246210
35MP0002822_catalepsy2.02608109
36MP0002736_abnormal_nociception_after2.02022070
37MP0002723_abnormal_immune_serum1.99855301
38MP0001800_abnormal_humoral_immune1.98533667
39MP0008260_abnormal_autophagy1.96399728
40MP0002735_abnormal_chemical_nociception1.94607740
41MP0000685_abnormal_immune_system1.91493054
42MP0002837_dystrophic_cardiac_calcinosis1.90590918
43MP0005671_abnormal_response_to1.90507654
44MP0003300_gastrointestinal_ulcer1.89922201
45MP0006276_abnormal_autonomic_nervous1.89310747
46MP0002734_abnormal_mechanical_nocicepti1.88055991
47MP0002452_abnormal_antigen_presenting1.85809608
48MP0004947_skin_inflammation1.84812374
49MP0003191_abnormal_cellular_cholesterol1.82294805
50MP0002557_abnormal_social/conspecific_i1.82117160
51MP0002420_abnormal_adaptive_immunity1.80887158
52MP0001819_abnormal_immune_cell1.80726056
53MP0003787_abnormal_imprinting1.78993416
54MP0002733_abnormal_thermal_nociception1.78609029
55MP0001501_abnormal_sleep_pattern1.78556828
56MP0004510_myositis1.77267135
57MP0002067_abnormal_sensory_capabilities1.75185697
58MP0001502_abnormal_circadian_rhythm1.74492167
59MP0001970_abnormal_pain_threshold1.73077536
60MP0003705_abnormal_hypodermis_morpholog1.70569487
61MP0000778_abnormal_nervous_system1.68582831
62MP0003879_abnormal_hair_cell1.57745757
63MP0004811_abnormal_neuron_physiology1.54392225
64MP0010155_abnormal_intestine_physiology1.51959052
65MP0002184_abnormal_innervation1.50016049
66MP0009764_decreased_sensitivity_to1.47885009
67MP0002405_respiratory_system_inflammati1.46514337
68MP0001845_abnormal_inflammatory_respons1.45328247
69MP0000751_myopathy1.44768175
70MP0001188_hyperpigmentation1.42304058
71MP0003329_amyloid_beta_deposits1.42087761
72MP0005464_abnormal_platelet_physiology1.41838561
73MP0006292_abnormal_olfactory_placode1.37356051
74MP0004858_abnormal_nervous_system1.36882131
75MP0008469_abnormal_protein_level1.35637858
76MP0009333_abnormal_splenocyte_physiolog1.35098609
77MP0008569_lethality_at_weaning1.33466110
78MP0004381_abnormal_hair_follicle1.33213735
79MP0005409_darkened_coat_color1.31993092
80MP0003646_muscle_fatigue1.31249151
81MP0000716_abnormal_immune_system1.29302447
82MP0002998_abnormal_bone_remodeling1.29221285
83MP0001529_abnormal_vocalization1.26147379
84MP0003453_abnormal_keratinocyte_physiol1.25759828
85MP0001986_abnormal_taste_sensitivity1.25052935
86MP0008004_abnormal_stomach_pH1.23883088
87MP0002933_joint_inflammation1.23877611
88MP0000858_altered_metastatic_potential1.23496552
89MP0004145_abnormal_muscle_electrophysio1.23160149
90MP0001958_emphysema1.22820251
91MP0000015_abnormal_ear_pigmentation1.22571156
92MP0003633_abnormal_nervous_system1.21650769
93MP0005166_decreased_susceptibility_to1.20771139
94MP0001849_ear_inflammation1.19935058
95MP0005397_hematopoietic_system_phenotyp1.19412381
96MP0001545_abnormal_hematopoietic_system1.19412381
97MP0004742_abnormal_vestibular_system1.19022067
98MP0002398_abnormal_bone_marrow1.17442360
99MP0002882_abnormal_neuron_morphology1.16788559
100MP0002066_abnormal_motor_capabilities/c1.16534663
101MP0000955_abnormal_spinal_cord1.15908296
102MP0004924_abnormal_behavior1.14147917
103MP0005386_behavior/neurological_phenoty1.14147917
104MP0005451_abnormal_body_composition1.12650055
105MP0003122_maternal_imprinting1.12189677
106MP0009780_abnormal_chondrocyte_physiolo1.11201329
107MP0002638_abnormal_pupillary_reflex1.10578182
108MP0003279_aneurysm1.09155004
109MP0005535_abnormal_body_temperature1.08395328
110MP0000343_altered_response_to1.08258163
111MP0002132_abnormal_respiratory_system1.06858277
112MP0003075_altered_response_to1.06299172
113MP0010386_abnormal_urinary_bladder1.06036068
114MP0003828_pulmonary_edema1.05737472
115MP0003763_abnormal_thymus_physiology1.05525994
116MP0005167_abnormal_blood-brain_barrier1.05525600
117MP0005390_skeleton_phenotype1.05243775
118MP0005551_abnormal_eye_electrophysiolog1.04040879
119MP0000465_gastrointestinal_hemorrhage1.02213914
120MP0003448_altered_tumor_morphology1.01774196
121MP0002429_abnormal_blood_cell1.01180158
122MP0005310_abnormal_salivary_gland1.00258383
123MP0002069_abnormal_eating/drinking_beha0.98805978
124MP0003806_abnormal_nucleotide_metabolis0.97892581
125MP0003283_abnormal_digestive_organ0.97343619
126MP0001873_stomach_inflammation0.96911510
127MP0003172_abnormal_lysosome_physiology0.96597334
128MP0004142_abnormal_muscle_tone0.96257460
129MP0003631_nervous_system_phenotype0.94977396
130MP0008961_abnormal_basal_metabolism0.93792210
131MP0004885_abnormal_endolymph0.92875215
132MP0002909_abnormal_adrenal_gland0.90502860
133MP0002722_abnormal_immune_system0.90093132
134MP0002229_neurodegeneration0.90006913
135MP0003866_abnormal_defecation0.89821261
136MP0002928_abnormal_bile_duct0.89620693
137MP0005174_abnormal_tail_pigmentation0.89425997
138MP0003183_abnormal_peptide_metabolism0.88548952
139MP0001905_abnormal_dopamine_level0.88355804
140MP0005076_abnormal_cell_differentiation0.86739636
141MP0008874_decreased_physiological_sensi0.86435328
142MP0002332_abnormal_exercise_endurance0.86004350
143MP0004130_abnormal_muscle_cell0.85887107
144MP0000689_abnormal_spleen_morphology0.85048066
145MP0001663_abnormal_digestive_system0.82898217
146MP0005083_abnormal_biliary_tract0.81980142
147MP0004085_abnormal_heartbeat0.81784830
148MP0003252_abnormal_bile_duct0.81744904
149MP0000604_amyloidosis0.81290460
150MP0000678_abnormal_parathyroid_gland0.81210609
151MP0005164_abnormal_response_to0.80498141
152MP0001963_abnormal_hearing_physiology0.79711856
153MP0003137_abnormal_impulse_conducting0.78928875
154MP0005499_abnormal_olfactory_system0.78796229
155MP0005394_taste/olfaction_phenotype0.78796229
156MP0005365_abnormal_bile_salt0.78593467
157MP0002277_abnormal_respiratory_mucosa0.78517516
158MP0002090_abnormal_vision0.78256392
159MP0004043_abnormal_pH_regulation0.76312184
160MP0008872_abnormal_physiological_respon0.75772900
161MP0004883_abnormal_blood_vessel0.75610169
162MP0000703_abnormal_thymus_morphology0.75356452
163MP0002653_abnormal_ependyma_morphology0.73305499
164MP0002152_abnormal_brain_morphology0.72499602
165MP0003690_abnormal_glial_cell0.71946498
166MP0002102_abnormal_ear_morphology0.71908902
167MP0000631_abnormal_neuroendocrine_gland0.71194593
168MP0000749_muscle_degeneration0.67062968
169MP0000920_abnormal_myelination0.66615612
170MP0001853_heart_inflammation0.66308462
171MP0004215_abnormal_myocardial_fiber0.65721931
172MP0002254_reproductive_system_inflammat0.65155121
173MP0002752_abnormal_somatic_nervous0.64686255
174MP0003091_abnormal_cell_migration0.64121074
175MP0000750_abnormal_muscle_regeneration0.64089374
176MP0002138_abnormal_hepatobiliary_system0.63575746
177MP0003795_abnormal_bone_structure0.63240706
178MP0005377_hearing/vestibular/ear_phenot0.61707471
179MP0000026_abnormal_inner_ear0.60618766
180MP0005448_abnormal_energy_balance0.59423155

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.48660713
2Febrile seizures (HP:0002373)4.76253180
3Eczematoid dermatitis (HP:0000976)4.67339716
4Myositis (HP:0100614)4.53712274
5Myokymia (HP:0002411)4.51652304
6Focal seizures (HP:0007359)4.45935622
7Abnormality of macrophages (HP:0004311)4.30054989
8Orchitis (HP:0100796)4.28585142
9Visual hallucinations (HP:0002367)4.21731656
10Epileptic encephalopathy (HP:0200134)4.14000096
11Recurrent abscess formation (HP:0002722)4.07532556
12Recurrent bacterial skin infections (HP:0005406)4.07087640
13Optic neuritis (HP:0100653)3.91742860
14Retrobulbar optic neuritis (HP:0100654)3.91742860
15Stomatitis (HP:0010280)3.46516913
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.41905131
17Abnormality of polysaccharide metabolism (HP:0011012)3.41905131
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.41905131
19Supranuclear gaze palsy (HP:0000605)3.39517929
20Atonic seizures (HP:0010819)3.37616229
21Thin bony cortex (HP:0002753)3.33896615
22Dysostosis multiplex (HP:0000943)3.32684647
23Progressive cerebellar ataxia (HP:0002073)3.21949438
24Gastrointestinal infarctions (HP:0005244)3.16309899
25Elevated erythrocyte sedimentation rate (HP:0003565)3.15386340
26Mucopolysacchariduria (HP:0008155)3.12956653
27Urinary glycosaminoglycan excretion (HP:0003541)3.12956653
28Mediastinal lymphadenopathy (HP:0100721)3.08984716
29Chronic obstructive pulmonary disease (HP:0006510)3.03521713
30Obstructive lung disease (HP:0006536)3.03521713
31Ankle clonus (HP:0011448)2.94171519
32Generalized tonic-clonic seizures (HP:0002069)2.91812611
33Generalized hypopigmentation of hair (HP:0011358)2.91097387
34Recurrent fungal infections (HP:0002841)2.84026106
35Protruding tongue (HP:0010808)2.83830898
36Poor eye contact (HP:0000817)2.80812884
37Bundle branch block (HP:0011710)2.78985057
38Obstructive sleep apnea (HP:0002870)2.78190155
39Abnormal eating behavior (HP:0100738)2.74332688
40Absence seizures (HP:0002121)2.73175288
41Loss of speech (HP:0002371)2.72916550
42Dialeptic seizures (HP:0011146)2.70993996
43Broad-based gait (HP:0002136)2.65367585
44Systemic lupus erythematosus (HP:0002725)2.64972085
45Increased IgE level (HP:0003212)2.63999666
46Torticollis (HP:0000473)2.59869037
47Recurrent skin infections (HP:0001581)2.59279468
48Hemorrhage of the eye (HP:0011885)2.58245441
49Annular pancreas (HP:0001734)2.57511950
50Impaired social interactions (HP:0000735)2.57257207
51Abnormal social behavior (HP:0012433)2.57257207
52Polyphagia (HP:0002591)2.55258221
53Postural instability (HP:0002172)2.54978898
54Hyperventilation (HP:0002883)2.54951893
55Meningitis (HP:0001287)2.54612769
56Keratoconjunctivitis sicca (HP:0001097)2.52415427
57Increased cerebral lipofuscin (HP:0011813)2.49979832
58Neuronal loss in central nervous system (HP:0002529)2.48972727
59Purpura (HP:0000979)2.45689395
60Syncope (HP:0001279)2.45486730
61Drooling (HP:0002307)2.42863826
62Excessive salivation (HP:0003781)2.42863826
63Gingivitis (HP:0000230)2.42505229
64Limb dystonia (HP:0002451)2.42261902
65Abnormal EKG (HP:0003115)2.42204783
66Pustule (HP:0200039)2.42164494
67Joint stiffness (HP:0001387)2.39580484
68Increased serum ferritin (HP:0003281)2.39300028
69Depression (HP:0000716)2.38906903
70Neurofibrillary tangles (HP:0002185)2.38474388
71Amyloidosis (HP:0011034)2.35658583
72Episodic fever (HP:0001954)2.35546574
73Keratoconjunctivitis (HP:0001096)2.34704318
74Hemoptysis (HP:0002105)2.33370029
75J-shaped sella turcica (HP:0002680)2.32016188
76Prolonged QT interval (HP:0001657)2.31731480
77Decreased circulating renin level (HP:0003351)2.29863399
78Peritonitis (HP:0002586)2.29158898
79Anxiety (HP:0000739)2.28337819
80Urinary bladder sphincter dysfunction (HP:0002839)2.28081958
81Stereotypic behavior (HP:0000733)2.27841219
82Failure to thrive in infancy (HP:0001531)2.25994549
83Vasculitis (HP:0002633)2.25325651
84Focal dystonia (HP:0004373)2.25213677
85Ventricular fibrillation (HP:0001663)2.25099471
86Prolonged bleeding time (HP:0003010)2.24274151
87Petechiae (HP:0000967)2.21807533
88Genetic anticipation (HP:0003743)2.20410356
89Progressive inability to walk (HP:0002505)2.20286984
90Cervical subluxation (HP:0003308)2.19187745
91Polygenic inheritance (HP:0010982)2.17625990
92Epileptiform EEG discharges (HP:0011182)2.16600699
93Pulmonary infiltrates (HP:0002113)2.16475564
94Absent speech (HP:0001344)2.16371409
95Encephalitis (HP:0002383)2.15265894
96Cellulitis (HP:0100658)2.14572477
97Gait imbalance (HP:0002141)2.14232719
98Abnormality of the nasal mucosa (HP:0000433)2.14118117
99Hypochromic anemia (HP:0001931)2.13487526
100Abnormal hair whorl (HP:0010721)2.12350494
101Craniofacial dystonia (HP:0012179)2.12174084
102Testicular atrophy (HP:0000029)2.11976895
103Fair hair (HP:0002286)2.10006798
104Anosmia (HP:0000458)2.08126046
105Spontaneous hematomas (HP:0007420)2.07251119
106Cerebral aneurysm (HP:0004944)2.06159164
107Emphysema (HP:0002097)2.06118801
108Gaze-evoked nystagmus (HP:0000640)2.05965865
109Left ventricular hypertrophy (HP:0001712)2.05770988
110Chronic mucocutaneous candidiasis (HP:0002728)2.05621102
111Recurrent cutaneous fungal infections (HP:0011370)2.05621102
112EEG with generalized epileptiform discharges (HP:0011198)2.05542527
113Primary atrial arrhythmia (HP:0001692)2.05444797
114Nuclear cataract (HP:0100018)2.05278950
115Hemiparesis (HP:0001269)2.05076054
116Atrial fibrillation (HP:0005110)2.04960077
117Exercise-induced myalgia (HP:0003738)2.04678286
118Abnormal delayed hypersensitivity skin test (HP:0002963)2.04432616
119Abnormality of salivation (HP:0100755)2.04380651
120Increased neuronal autofluorescent lipopigment (HP:0002074)2.03996726
121Colitis (HP:0002583)2.03280699
122Easy fatigability (HP:0003388)2.03090548
123Thyroid-stimulating hormone excess (HP:0002925)2.02760010
124Stridor (HP:0010307)2.02681776
125Inability to walk (HP:0002540)2.02658934
126Sudden death (HP:0001699)2.00315257
127Papilledema (HP:0001085)1.99423756
128Epistaxis (HP:0000421)1.98790126
129Truncal ataxia (HP:0002078)1.98748566
130Status epilepticus (HP:0002133)1.98715122
131Segmental peripheral demyelination/remyelination (HP:0003481)1.97901961
132Retinal atrophy (HP:0001105)1.96269421
133Acne (HP:0001061)1.95877753
134Abnormality of the endocardium (HP:0004306)1.95709429
135Nasal polyposis (HP:0100582)1.95464621
136Iris hypopigmentation (HP:0007730)1.95354285
137Dysmetria (HP:0001310)1.94803214
138Axonal loss (HP:0003447)1.94506110
139Medial flaring of the eyebrow (HP:0010747)1.94226704
140Gastrointestinal inflammation (HP:0004386)1.93952516
141Hypsarrhythmia (HP:0002521)1.93480511
142Urticaria (HP:0001025)1.93216172
143Malnutrition (HP:0004395)1.93175986
144Mutism (HP:0002300)1.92655213
145Impaired vibration sensation in the lower limbs (HP:0002166)1.92459987
146Abnormality of iron homeostasis (HP:0011031)1.92340507
147Recurrent gram-negative bacterial infections (HP:0005420)1.91715495
148Anorexia (HP:0002039)1.90697141
149Ulnar bowing (HP:0003031)1.90505710
150Generalized hypopigmentation (HP:0007513)1.90315465
151Supraventricular tachycardia (HP:0004755)1.89548009
152Hepatosplenomegaly (HP:0001433)1.89039573
153Sleep apnea (HP:0010535)1.88270557
154Inflammation of the large intestine (HP:0002037)1.85889761
155Tented upper lip vermilion (HP:0010804)1.85411756
156Fetal akinesia sequence (HP:0001989)1.85312751
157Dysdiadochokinesis (HP:0002075)1.85309039
158Broad face (HP:0000283)1.85279447
159Hypothermia (HP:0002045)1.84296161
160Vacuolated lymphocytes (HP:0001922)1.82881826
161Turricephaly (HP:0000262)1.82483673
162Rapidly progressive (HP:0003678)1.81402951
163Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80665043
164Blue irides (HP:0000635)1.79920343
165Abnormality of binocular vision (HP:0011514)1.79434267
166Diplopia (HP:0000651)1.79434267
167Nephrogenic diabetes insipidus (HP:0009806)1.79385911
168Chest pain (HP:0100749)1.78913640
169Retinal dysplasia (HP:0007973)1.78472605
170Pulmonary embolism (HP:0002204)1.78234095
171Joint hemorrhage (HP:0005261)1.78125411
172Hyperacusis (HP:0010780)1.77950949
173Supraventricular arrhythmia (HP:0005115)1.77722702
174Intellectual disability, severe (HP:0010864)1.77663220
175Agitation (HP:0000713)1.77142803
176Calf muscle hypertrophy (HP:0008981)1.77024097
177Insomnia (HP:0100785)1.76842018
178Interstitial pulmonary disease (HP:0006530)1.76621252
179Action tremor (HP:0002345)1.75755982
180Bradycardia (HP:0001662)1.75665368
181Elfin facies (HP:0004428)1.75245375
182Lower limb amyotrophy (HP:0007210)1.74128485
183Congenital primary aphakia (HP:0007707)1.74082601
184Urinary urgency (HP:0000012)1.73946439
185Cortical visual impairment (HP:0100704)1.73094803
186Exotropia (HP:0000577)1.72494517
187Abnormality of glycolipid metabolism (HP:0010969)1.72004813
188Abnormality of liposaccharide metabolism (HP:0010968)1.72004813
189Abnormality of glycosphingolipid metabolism (HP:0004343)1.72004813
190Hypoventilation (HP:0002791)1.71598875
191Psychosis (HP:0000709)1.70632526
192Amblyopia (HP:0000646)1.69241714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.66849337
2ERN13.15354198
3MAP4K13.14247276
4TRIB33.10957072
5EPHA43.10952483
6TNIK2.90116950
7MARK12.80256451
8DAPK22.76284798
9SIK32.50147758
10MAP2K72.46018350
11SIK12.35694369
12RIPK42.33355993
13SIK22.33309310
14CASK2.28000092
15MAP3K42.22457640
16MINK12.16884771
17TYK22.06094649
18MAP3K111.89945705
19IRAK31.85819467
20ZAP701.85138957
21MAP2K41.83152261
22GRK61.76177801
23RIPK11.75069213
24CAMKK11.74428522
25MAP3K91.69886531
26MAPK131.68301091
27TAOK11.67852449
28EPHB11.63596441
29PRPF4B1.62707509
30CSK1.60681571
31PAK61.58044557
32BMPR21.56925420
33NTRK21.55863991
34MAP3K31.46914476
35SGK21.46262247
36FES1.44778703
37MAP3K131.42935302
38SGK2231.40746552
39SGK4941.40746552
40CDC42BPA1.39352240
41UHMK11.38130555
42TAOK21.31063508
43PHKG11.29055131
44PHKG21.29055131
45SGK31.25123814
46KSR11.24002672
47STK381.17948582
48PINK11.17752976
49JAK31.14874042
50MAP3K121.14850868
51SMG11.14779461
52PTK61.14681102
53DAPK11.14603440
54CAMK11.14196121
55MAP3K141.11194877
56MAP3K11.10026092
57CAMK1G1.09690181
58IRAK21.08248013
59INSRR1.07161990
60CDK51.06507691
61PRKD31.04190980
62CAMK41.04054932
63PDPK11.03056862
64FGR1.01641698
65MAP2K61.01502077
66IRAK41.01169093
67BTK1.01066730
68MAP3K71.01031682
69DMPK0.98740576
70MAPK150.97528589
71ICK0.97348674
72MARK20.96416758
73PRKCH0.96149666
74FGFR40.95903315
75IKBKB0.93825374
76RPS6KA20.90503875
77CAMKK20.84132933
78JAK20.83937604
79GRK70.83718557
80PKN20.83094250
81ERBB30.81687958
82JAK10.81408957
83BMX0.81160698
84NME20.79376747
85TESK10.79142711
86PDK10.77673396
87DYRK1B0.77331635
88MATK0.77173821
89CAMK2A0.77020199
90PIK3CG0.74950101
91LMTK20.72688004
92BLK0.72257786
93CLK10.71784672
94CDK30.71528984
95MAP3K60.71490330
96RPS6KL10.71359175
97RPS6KC10.71359175
98LYN0.70492287
99WNK30.70332172
100SGK10.70057389
101CAMK2B0.68779073
102NTRK10.68462490
103HIPK20.66978005
104CSF1R0.66840698
105PKN10.66781922
106IRAK10.66505789
107PRKCG0.65856273
108DDR20.65362297
109CAMK2D0.64431979
110PRKCE0.64061759
111PRKG20.62519185
112PRKCZ0.62222096
113MARK30.58669109
114RPS6KA60.58450462
115ADRBK20.57649591
116CDK180.55730943
117TYRO30.55692392
118LCK0.54690287
119TESK20.53022563
120SYK0.52643390
121DYRK1A0.52094254
122MAPK120.50298159
123FYN0.49315030
124BCR0.48886394
125PAK30.48663879
126STK110.47542068
127CDK150.45755065
128BRD40.45488452
129HCK0.45158357
130GRK50.44908065
131MAPK70.44403771
132CDK190.44323011
133CCNB10.42876593
134PRKG10.42382441
135PTK2B0.41967003
136CAMK1D0.41571850
137ARAF0.41415829
138TGFBR20.41259919
139CDK11A0.40935624
140NEK60.40884702
141PIM20.40159696
142PRKD10.40042272
143ITK0.38949680
144RET0.38473027
145KSR20.37958873
146MAP2K30.37780484
147TBK10.36632455
148ERBB20.36470092
149RPS6KA30.36321585
150MAP2K20.36211027
151CHUK0.35795247
152TXK0.34919364
153PRKD20.34880578
154BRAF0.34795244
155TNK20.34392586
156IKBKE0.34089253
157KIT0.32099198
158MAPK40.32000888

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.40441929
2Other glycan degradation_Homo sapiens_hsa005112.81681576
3Synaptic vesicle cycle_Homo sapiens_hsa047212.76166307
4Olfactory transduction_Homo sapiens_hsa047402.74763497
5Circadian entrainment_Homo sapiens_hsa047132.36963610
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34474084
7Morphine addiction_Homo sapiens_hsa050322.34052086
8GABAergic synapse_Homo sapiens_hsa047272.22267943
9Glutamatergic synapse_Homo sapiens_hsa047242.16163959
10Insulin secretion_Homo sapiens_hsa049112.02467494
11Tuberculosis_Homo sapiens_hsa051521.88930060
12Taste transduction_Homo sapiens_hsa047421.87294957
13Amphetamine addiction_Homo sapiens_hsa050311.85319543
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79530087
15Malaria_Homo sapiens_hsa051441.74970172
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72988875
17Cholinergic synapse_Homo sapiens_hsa047251.72291863
18Cocaine addiction_Homo sapiens_hsa050301.72020274
19Dopaminergic synapse_Homo sapiens_hsa047281.71136366
20Salivary secretion_Homo sapiens_hsa049701.67099375
21Long-term potentiation_Homo sapiens_hsa047201.62759086
22Calcium signaling pathway_Homo sapiens_hsa040201.61576666
23Acute myeloid leukemia_Homo sapiens_hsa052211.58556982
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56816019
25Serotonergic synapse_Homo sapiens_hsa047261.54954750
26TNF signaling pathway_Homo sapiens_hsa046681.52233541
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.52143682
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47976988
29Type II diabetes mellitus_Homo sapiens_hsa049301.47019263
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44493858
31Allograft rejection_Homo sapiens_hsa053301.43536145
32Collecting duct acid secretion_Homo sapiens_hsa049661.43166446
33Renin secretion_Homo sapiens_hsa049241.42018164
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41185754
35Gastric acid secretion_Homo sapiens_hsa049711.37773723
36Oxytocin signaling pathway_Homo sapiens_hsa049211.36527938
37Graft-versus-host disease_Homo sapiens_hsa053321.35980466
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32931768
39Toxoplasmosis_Homo sapiens_hsa051451.30456245
40cAMP signaling pathway_Homo sapiens_hsa040241.27548644
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26890946
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24734670
43Influenza A_Homo sapiens_hsa051641.24517362
44Hepatitis C_Homo sapiens_hsa051601.23093588
45African trypanosomiasis_Homo sapiens_hsa051431.19911525
46Notch signaling pathway_Homo sapiens_hsa043301.19227945
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19013970
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17166959
49Autoimmune thyroid disease_Homo sapiens_hsa053201.14854033
50T cell receptor signaling pathway_Homo sapiens_hsa046601.10691852
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10272241
52Salmonella infection_Homo sapiens_hsa051321.08446722
53GnRH signaling pathway_Homo sapiens_hsa049121.06372157
54Phagosome_Homo sapiens_hsa041451.05771228
55Long-term depression_Homo sapiens_hsa047301.05739321
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05611906
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04359350
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02505655
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02375211
60Legionellosis_Homo sapiens_hsa051341.01929987
61Hematopoietic cell lineage_Homo sapiens_hsa046401.00726935
62Measles_Homo sapiens_hsa051621.00447443
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.99592392
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99199680
65Cardiac muscle contraction_Homo sapiens_hsa042600.96550610
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95499591
67Axon guidance_Homo sapiens_hsa043600.94903290
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.94124875
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93404802
70Endocytosis_Homo sapiens_hsa041440.90723800
71Non-small cell lung cancer_Homo sapiens_hsa052230.89041302
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.88764595
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88185053
74Hepatitis B_Homo sapiens_hsa051610.87936049
75Fructose and mannose metabolism_Homo sapiens_hsa000510.87435991
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86212634
77Chronic myeloid leukemia_Homo sapiens_hsa052200.85548153
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.84983238
79Butanoate metabolism_Homo sapiens_hsa006500.82947346
80Dilated cardiomyopathy_Homo sapiens_hsa054140.82001438
81Bladder cancer_Homo sapiens_hsa052190.81676109
82Amoebiasis_Homo sapiens_hsa051460.81028167
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80569100
84Herpes simplex infection_Homo sapiens_hsa051680.80505397
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78674187
86Sulfur relay system_Homo sapiens_hsa041220.76643444
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76185350
88ABC transporters_Homo sapiens_hsa020100.75246981
89Apoptosis_Homo sapiens_hsa042100.75128407
90mTOR signaling pathway_Homo sapiens_hsa041500.73665774
91Gap junction_Homo sapiens_hsa045400.73579667
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73069948
93Primary immunodeficiency_Homo sapiens_hsa053400.73025943
94Asthma_Homo sapiens_hsa053100.72762872
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.71637935
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.71016917
97Platelet activation_Homo sapiens_hsa046110.69462806
98Viral myocarditis_Homo sapiens_hsa054160.68528968
99MAPK signaling pathway_Homo sapiens_hsa040100.67637306
100Chemokine signaling pathway_Homo sapiens_hsa040620.67245038
101ErbB signaling pathway_Homo sapiens_hsa040120.66494961
102Type I diabetes mellitus_Homo sapiens_hsa049400.66207402
103Circadian rhythm_Homo sapiens_hsa047100.65307019
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65302858
105Shigellosis_Homo sapiens_hsa051310.63586277
106Glioma_Homo sapiens_hsa052140.63535462
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63053164
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61954021
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.61698936
110Staphylococcus aureus infection_Homo sapiens_hsa051500.60737909
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60371173
112Antigen processing and presentation_Homo sapiens_hsa046120.60143337
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60054903
114Insulin resistance_Homo sapiens_hsa049310.59842601
115Insulin signaling pathway_Homo sapiens_hsa049100.57879256
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.57471068
117Vibrio cholerae infection_Homo sapiens_hsa051100.56456237
118Estrogen signaling pathway_Homo sapiens_hsa049150.56408121
119Pancreatic cancer_Homo sapiens_hsa052120.56257884
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.55158912
121Melanogenesis_Homo sapiens_hsa049160.54881682
122Renal cell carcinoma_Homo sapiens_hsa052110.53284488
123Osteoclast differentiation_Homo sapiens_hsa043800.53090999
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52848163
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51730879
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51196502
127Choline metabolism in cancer_Homo sapiens_hsa052310.49835171
128VEGF signaling pathway_Homo sapiens_hsa043700.49255467
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48707398
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48219200
131Pancreatic secretion_Homo sapiens_hsa049720.47045219
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46568559
133B cell receptor signaling pathway_Homo sapiens_hsa046620.45745916
134Lysine degradation_Homo sapiens_hsa003100.44387159
135Glucagon signaling pathway_Homo sapiens_hsa049220.43925503
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42845829
137Bile secretion_Homo sapiens_hsa049760.42729306
138Inositol phosphate metabolism_Homo sapiens_hsa005620.42427098
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42268289
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.41559426
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.40598447
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40411929
143Prion diseases_Homo sapiens_hsa050200.39595903
144Ras signaling pathway_Homo sapiens_hsa040140.39460579
145Caffeine metabolism_Homo sapiens_hsa002320.39431056
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39146300
147Pertussis_Homo sapiens_hsa051330.39053755
148Leishmaniasis_Homo sapiens_hsa051400.38548987
149Rheumatoid arthritis_Homo sapiens_hsa053230.37278522
150Prolactin signaling pathway_Homo sapiens_hsa049170.37013405
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36985224
152Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36908727
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35917956
154Alzheimers disease_Homo sapiens_hsa050100.35327568
155Lysosome_Homo sapiens_hsa041420.33908342

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