VRK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.16682982
2telomere maintenance via semi-conservative replication (GO:0032201)5.01170991
3DNA strand elongation (GO:0022616)4.93505964
4DNA replication initiation (GO:0006270)4.71464649
5telomere maintenance via recombination (GO:0000722)4.61508164
6DNA replication checkpoint (GO:0000076)4.59622168
7DNA unwinding involved in DNA replication (GO:0006268)4.56721421
8establishment of integrated proviral latency (GO:0075713)4.54391220
9DNA ligation (GO:0006266)4.49565964
10mitotic recombination (GO:0006312)4.43041498
11protein localization to kinetochore (GO:0034501)4.32404275
12ribosomal small subunit assembly (GO:0000028)4.31955522
13mitotic metaphase plate congression (GO:0007080)4.22173560
14CENP-A containing nucleosome assembly (GO:0034080)4.19144330
15chromatin remodeling at centromere (GO:0031055)4.05975104
16telomere maintenance via telomere lengthening (GO:0010833)4.01565796
17kinetochore organization (GO:0051383)3.97741903
18DNA topological change (GO:0006265)3.93275845
19nucleotide-excision repair, DNA gap filling (GO:0006297)3.87419059
20DNA double-strand break processing (GO:0000729)3.85870508
21DNA replication-independent nucleosome organization (GO:0034724)3.84512806
22DNA replication-independent nucleosome assembly (GO:0006336)3.84512806
23negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.82806651
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.82574296
25nucleobase biosynthetic process (GO:0046112)3.82440246
26regulation of centriole replication (GO:0046599)3.79949873
27protein localization to chromosome, centromeric region (GO:0071459)3.79758385
28mitotic spindle checkpoint (GO:0071174)3.75570223
29mitotic sister chromatid cohesion (GO:0007064)3.75321147
30attachment of spindle microtubules to kinetochore (GO:0008608)3.74803683
31metaphase plate congression (GO:0051310)3.72632057
32formation of translation preinitiation complex (GO:0001731)3.67800933
33* mitotic nuclear envelope disassembly (GO:0007077)3.66316123
34DNA replication-dependent nucleosome assembly (GO:0006335)3.65824300
35DNA replication-dependent nucleosome organization (GO:0034723)3.65824300
36mitotic spindle assembly checkpoint (GO:0007094)3.62153830
37maturation of SSU-rRNA (GO:0030490)3.59971637
38purine nucleobase biosynthetic process (GO:0009113)3.59164240
39spindle assembly checkpoint (GO:0071173)3.58342219
40regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.57956400
41regulation of chromosome segregation (GO:0051983)3.57592927
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.57285730
43regulation of mitotic spindle checkpoint (GO:1903504)3.56519789
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56519789
45kinetochore assembly (GO:0051382)3.54796222
46DNA deamination (GO:0045006)3.53154149
47establishment of chromosome localization (GO:0051303)3.51514682
48replication fork processing (GO:0031297)3.51079674
49regulation of sister chromatid segregation (GO:0033045)3.50139856
50regulation of mitotic sister chromatid separation (GO:0010965)3.50139856
51regulation of mitotic sister chromatid segregation (GO:0033047)3.50139856
52mitotic chromosome condensation (GO:0007076)3.45932551
53establishment of viral latency (GO:0019043)3.44085222
54IMP biosynthetic process (GO:0006188)3.43674833
55meiotic chromosome segregation (GO:0045132)3.42505515
56histone exchange (GO:0043486)3.39500794
57regulation of DNA endoreduplication (GO:0032875)3.38988078
58mitotic sister chromatid segregation (GO:0000070)3.38754601
59non-recombinational repair (GO:0000726)3.37520015
60double-strand break repair via nonhomologous end joining (GO:0006303)3.37520015
61viral transcription (GO:0019083)3.35904797
62* nuclear envelope disassembly (GO:0051081)3.34436782
63* membrane disassembly (GO:0030397)3.34436782
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32879552
65establishment of protein localization to mitochondrial membrane (GO:0090151)3.32519738
66ATP-dependent chromatin remodeling (GO:0043044)3.32242019
67DNA catabolic process, exonucleolytic (GO:0000738)3.30482273
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30337531
69translational termination (GO:0006415)3.29453013
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29123371
71negative regulation of ligase activity (GO:0051352)3.29123371
72regulation of spindle organization (GO:0090224)3.28018024
73centriole replication (GO:0007099)3.26023588
74nuclear pore organization (GO:0006999)3.25381446
75telomere maintenance (GO:0000723)3.25263294
76synapsis (GO:0007129)3.24846750
77ribosomal large subunit biogenesis (GO:0042273)3.23710467
78telomere organization (GO:0032200)3.23633534
79mitotic G2/M transition checkpoint (GO:0044818)3.22123178
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21983338
81microtubule depolymerization (GO:0007019)3.18855878
82mismatch repair (GO:0006298)3.17967678
83folic acid-containing compound biosynthetic process (GO:0009396)3.17547640
84sister chromatid segregation (GO:0000819)3.15644091
85transcription-coupled nucleotide-excision repair (GO:0006283)3.12442923
86ribosomal small subunit biogenesis (GO:0042274)3.12412958
87ribonucleoprotein complex biogenesis (GO:0022613)3.11027053
88regulation of centrosome cycle (GO:0046605)3.10854902
89histone mRNA metabolic process (GO:0008334)3.09697528
90ribosome biogenesis (GO:0042254)3.09409415
91IMP metabolic process (GO:0046040)3.09158280
92translational elongation (GO:0006414)3.09053611
93negative regulation of mitosis (GO:0045839)3.07811697
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07419028
95resolution of meiotic recombination intermediates (GO:0000712)3.07417576
96regulation of helicase activity (GO:0051095)3.07044618
97viral mRNA export from host cell nucleus (GO:0046784)3.05396109
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04655976
99translational initiation (GO:0006413)3.04538326
100spliceosomal snRNP assembly (GO:0000387)3.03267628
101nuclear pore complex assembly (GO:0051292)3.02997928
102somatic hypermutation of immunoglobulin genes (GO:0016446)3.02786841
103somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02786841
104protein localization to chromosome (GO:0034502)3.02180403
105pseudouridine synthesis (GO:0001522)3.00635722
106ribosome assembly (GO:0042255)2.99814481
107rRNA processing (GO:0006364)2.99457705
108regulation of double-strand break repair via homologous recombination (GO:0010569)2.98275969
109cotranslational protein targeting to membrane (GO:0006613)2.97299174
110G1/S transition of mitotic cell cycle (GO:0000082)2.96773986
111cell cycle G1/S phase transition (GO:0044843)2.96773986
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.96546977
113proteasome assembly (GO:0043248)2.95683473
114regulation of nuclear cell cycle DNA replication (GO:0033262)2.94546862
115protein targeting to ER (GO:0045047)2.94312059
116positive regulation of chromosome segregation (GO:0051984)2.93557667
117negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92554002
118spindle checkpoint (GO:0031577)2.91642624
119regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90397152
120DNA duplex unwinding (GO:0032508)2.89838872
121rRNA metabolic process (GO:0016072)2.89687211
122translesion synthesis (GO:0019985)2.89328267
123DNA geometric change (GO:0032392)2.89197450
124nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88900362
125spliceosomal complex assembly (GO:0000245)2.88427855
126maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88375953
127chromatin assembly or disassembly (GO:0006333)2.88086338
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88021659
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.84761751
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84761751
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84761751
132negative regulation of sister chromatid segregation (GO:0033046)2.84761751
133negative regulation of chromosome segregation (GO:0051985)2.84672453
134base-excision repair (GO:0006284)2.84189259
135rRNA modification (GO:0000154)2.83922794
136exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83687050
137postreplication repair (GO:0006301)2.83476617
138regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83308166
139DNA replication (GO:0006260)2.83205360
140chromosome segregation (GO:0007059)2.83175148
141RNA splicing, via transesterification reactions (GO:0000375)2.82760195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.25174781
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.22074534
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.94250604
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.92565741
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53479262
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44421445
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31572122
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.02425471
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.95468072
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70681877
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64231310
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62667084
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.62371053
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62333535
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55981721
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47002051
17VDR_23849224_ChIP-Seq_CD4+_Human2.36850470
18* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31583949
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19408655
20XRN2_22483619_ChIP-Seq_HELA_Human2.18965843
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18879733
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16388195
23* E2F1_21310950_ChIP-Seq_MCF-7_Human2.10903251
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09609013
25FOXP3_21729870_ChIP-Seq_TREG_Human2.09156835
26AR_21909140_ChIP-Seq_LNCAP_Human2.04137703
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03153070
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96694360
29DCP1A_22483619_ChIP-Seq_HELA_Human1.95075542
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.90746796
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90322411
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86352545
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83816456
34GABP_19822575_ChIP-Seq_HepG2_Human1.82582453
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.82355279
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81997596
37ELK1_19687146_ChIP-ChIP_HELA_Human1.80494599
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76896546
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75528024
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74298219
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74219039
42TTF2_22483619_ChIP-Seq_HELA_Human1.73489754
43* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71290918
44CIITA_25753668_ChIP-Seq_RAJI_Human1.63020572
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61738678
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60920887
47MYC_22102868_ChIP-Seq_BL_Human1.60151443
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57170020
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54904497
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54492071
51* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54049405
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52644773
53* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50819449
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50232725
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49965496
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44205968
57EWS_26573619_Chip-Seq_HEK293_Human1.42779647
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.42265096
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.41041942
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37927904
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35026476
62KDM5A_27292631_Chip-Seq_BREAST_Human1.34690337
63SPI1_23547873_ChIP-Seq_NB4_Human1.33536664
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32103001
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31692547
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29633732
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.28810742
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22907184
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22199948
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21858051
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20402244
72FUS_26573619_Chip-Seq_HEK293_Human1.19933205
73TFEB_21752829_ChIP-Seq_HELA_Human1.19111414
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17693812
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.17460514
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.16891421
77VDR_21846776_ChIP-Seq_THP-1_Human1.14131923
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13074949
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.13040185
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12323474
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11639757
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.08271866
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07790316
84MYC_18940864_ChIP-ChIP_HL60_Human1.06651216
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03240710
86IRF1_19129219_ChIP-ChIP_H3396_Human1.00026122
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97940346
88KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96694885
89IRF8_22096565_ChIP-ChIP_GC-B_Human0.95043918
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94866780
91VDR_22108803_ChIP-Seq_LS180_Human0.94758869
92ZNF274_21170338_ChIP-Seq_K562_Hela0.94197168
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93232985
94* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92912135
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92397256
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87645546
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87359208
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87030096
99MYB_26560356_Chip-Seq_TH2_Human0.86545481
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86355286
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86016601
102* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85634583
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85523616
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85415483
105SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85069634
106MYB_26560356_Chip-Seq_TH1_Human0.82701491
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80651405
108* SOX17_20123909_ChIP-Seq_XEN_Mouse0.80477762
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79449475
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79406292
111IGF1R_20145208_ChIP-Seq_DFB_Human0.79120458
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78568776
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78344615
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.77690348
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.77113895
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75852086
117RUNX1_22412390_ChIP-Seq_EML_Mouse0.75603843
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.75532757
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.60296016
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.59512876
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.57143410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.21943971
2MP0010094_abnormal_chromosome_stability4.81175264
3MP0003111_abnormal_nucleus_morphology4.31321494
4MP0004957_abnormal_blastocyst_morpholog4.09031136
5MP0008057_abnormal_DNA_replication3.97416130
6MP0003077_abnormal_cell_cycle3.96870526
7MP0008058_abnormal_DNA_repair3.42373012
8MP0002396_abnormal_hematopoietic_system3.03041862
9MP0008007_abnormal_cellular_replicative2.98737707
10MP0009697_abnormal_copulation2.52448524
11MP0008932_abnormal_embryonic_tissue2.36574281
12MP0001835_abnormal_antigen_presentation2.07677323
13MP0000350_abnormal_cell_proliferation1.99615709
14MP0003890_abnormal_embryonic-extraembry1.96545224
15MP0000490_abnormal_crypts_of1.95916088
16MP0004808_abnormal_hematopoietic_stem1.90565752
17MP0008877_abnormal_DNA_methylation1.89935080
18MP0001730_embryonic_growth_arrest1.87492575
19MP0003123_paternal_imprinting1.82879330
20MP0010307_abnormal_tumor_latency1.81992772
21MP0003763_abnormal_thymus_physiology1.80506227
22MP0009333_abnormal_splenocyte_physiolog1.78824941
23MP0006035_abnormal_mitochondrial_morpho1.73227392
24MP0002398_abnormal_bone_marrow1.73102026
25MP0003786_premature_aging1.70947835
26MP0002019_abnormal_tumor_incidence1.53949653
27MP0005397_hematopoietic_system_phenotyp1.52716500
28MP0001545_abnormal_hematopoietic_system1.52716500
29MP0005671_abnormal_response_to1.50127046
30MP0000703_abnormal_thymus_morphology1.49114108
31MP0000313_abnormal_cell_death1.48496175
32MP0003941_abnormal_skin_development1.45973502
33MP0002722_abnormal_immune_system1.45529305
34MP0010352_gastrointestinal_tract_polyps1.44440857
35MP0000689_abnormal_spleen_morphology1.43720914
36MP0002102_abnormal_ear_morphology1.43002750
37MP0006072_abnormal_retinal_apoptosis1.42572544
38MP0005174_abnormal_tail_pigmentation1.42414141
39MP0006054_spinal_hemorrhage1.40889358
40MP0001697_abnormal_embryo_size1.40878921
41MP0006036_abnormal_mitochondrial_physio1.40236025
42MP0005380_embryogenesis_phenotype1.38440766
43MP0001672_abnormal_embryogenesis/_devel1.38440766
44MP0008995_early_reproductive_senescence1.36562655
45MP0002080_prenatal_lethality1.35471044
46MP0001800_abnormal_humoral_immune1.35223921
47MP0001529_abnormal_vocalization1.35214358
48MP0002429_abnormal_blood_cell1.34642982
49MP0005075_abnormal_melanosome_morpholog1.32731723
50MP0000716_abnormal_immune_system1.31560996
51MP0002420_abnormal_adaptive_immunity1.31210211
52MP0001819_abnormal_immune_cell1.30014348
53MP0004147_increased_porphyrin_level1.29520922
54MP0008789_abnormal_olfactory_epithelium1.28681318
55MP0002452_abnormal_antigen_presenting1.26951366
56MP0001853_heart_inflammation1.26401302
57MP0009785_altered_susceptibility_to1.25176062
58MP0003937_abnormal_limbs/digits/tail_de1.24793729
59MP0003984_embryonic_growth_retardation1.24517626
60MP0000372_irregular_coat_pigmentation1.24001017
61MP0006292_abnormal_olfactory_placode1.21797463
62MP0002088_abnormal_embryonic_growth/wei1.21301053
63MP0003718_maternal_effect1.19255154
64MP0000685_abnormal_immune_system1.19198473
65MP0003567_abnormal_fetal_cardiomyocyte1.19080057
66MP0009672_abnormal_birth_weight1.16187450
67MP0002723_abnormal_immune_serum1.15306163
68MP0003121_genomic_imprinting1.11309096
69MP0000858_altered_metastatic_potential1.11152339
70MP0002085_abnormal_embryonic_tissue1.10494277
71MP0002086_abnormal_extraembryonic_tissu1.07843079
72MP0002095_abnormal_skin_pigmentation1.07820942
73MP0005025_abnormal_response_to1.07796940
74MP0000015_abnormal_ear_pigmentation1.04738205
75MP0001188_hyperpigmentation1.04175307
76MP0005000_abnormal_immune_tolerance1.03877984
77MP0001286_abnormal_eye_development1.02652821
78MP0002405_respiratory_system_inflammati0.98354060
79* MP0003698_abnormal_male_reproductive0.98028783
80* MP0002210_abnormal_sex_determination0.97257569
81MP0002084_abnormal_developmental_patter0.96848773
82MP0002148_abnormal_hypersensitivity_rea0.95479659
83MP0005499_abnormal_olfactory_system0.93772270
84MP0005394_taste/olfaction_phenotype0.93772270
85MP0000465_gastrointestinal_hemorrhage0.93643013
86MP0001986_abnormal_taste_sensitivity0.89603503
87MP0004197_abnormal_fetal_growth/weight/0.89017878
88MP0002419_abnormal_innate_immunity0.88349671
89MP0009379_abnormal_foot_pigmentation0.87555672
90* MP0001145_abnormal_male_reproductive0.85638954
91MP0003186_abnormal_redox_activity0.84841197
92MP0002160_abnormal_reproductive_system0.84257642
93MP0001293_anophthalmia0.83956172
94MP0002132_abnormal_respiratory_system0.83683528
95MP0002736_abnormal_nociception_after0.82480629
96MP0003315_abnormal_perineum_morphology0.81933059
97MP0002697_abnormal_eye_size0.81761558
98MP0003436_decreased_susceptibility_to0.81605954
99MP0003119_abnormal_digestive_system0.81073629
100MP0001790_abnormal_immune_system0.79780240
101MP0005387_immune_system_phenotype0.79780240
102MP0000358_abnormal_cell_content/0.78910591
103MP0002233_abnormal_nose_morphology0.77826922
104MP0002111_abnormal_tail_morphology0.77545867
105MP0010155_abnormal_intestine_physiology0.77369992
106MP0002751_abnormal_autonomic_nervous0.77238707
107MP0009703_decreased_birth_body0.77226005
108MP0003787_abnormal_imprinting0.77068594
109MP0002234_abnormal_pharynx_morphology0.76930200
110MP0004264_abnormal_extraembryonic_tissu0.76911515
111MP0003136_yellow_coat_color0.76496860
112MP0002166_altered_tumor_susceptibility0.76014686
113MP0005395_other_phenotype0.76003828
114MP0001119_abnormal_female_reproductive0.75684331
115MP0002006_tumorigenesis0.75422859
116MP0010030_abnormal_orbit_morphology0.74552619
117* MP0001929_abnormal_gametogenesis0.74406373
118MP0003943_abnormal_hepatobiliary_system0.74194523
119* MP0002161_abnormal_fertility/fecundity0.73657574
120MP0003221_abnormal_cardiomyocyte_apopto0.72911373
121MP0003866_abnormal_defecation0.72349973
122MP0005384_cellular_phenotype0.71950745
123MP0005464_abnormal_platelet_physiology0.71790075
124MP0003806_abnormal_nucleotide_metabolis0.71626188
125MP0003656_abnormal_erythrocyte_physiolo0.70508359
126* MP0000653_abnormal_sex_gland0.70162289
127MP0001764_abnormal_homeostasis0.69783023
128MP0009278_abnormal_bone_marrow0.69778556
129MP0005076_abnormal_cell_differentiation0.68165859
130MP0005084_abnormal_gallbladder_morpholo0.67318542
131* MP0003699_abnormal_female_reproductive0.66193828
132MP0002938_white_spotting0.65641007
133MP0005253_abnormal_eye_physiology0.65554476
134MP0000631_abnormal_neuroendocrine_gland0.65528761
135MP0005621_abnormal_cell_physiology0.63874835
136MP0005389_reproductive_system_phenotype0.63620584
137MP0002075_abnormal_coat/hair_pigmentati0.62606557
138MP0000049_abnormal_middle_ear0.62475804
139MP0005391_vision/eye_phenotype0.62459090
140MP0005410_abnormal_fertilization0.62133456
141MP0003861_abnormal_nervous_system0.61612079
142MP0002163_abnormal_gland_morphology0.60893863
143MP0001727_abnormal_embryo_implantation0.56118363
144MP0005408_hypopigmentation0.53579496
145MP0000647_abnormal_sebaceous_gland0.52434325
146MP0005266_abnormal_metabolism0.50150610

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.19932512
2Reticulocytopenia (HP:0001896)4.14948562
3Abnormal number of erythroid precursors (HP:0012131)4.04750617
4Abnormality of cells of the erythroid lineage (HP:0012130)4.04296740
5Abnormality of the labia minora (HP:0012880)3.81963511
6Chromsome breakage (HP:0040012)3.72196886
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48983670
8Abnormality of chromosome stability (HP:0003220)3.32961029
9Abnormality of the preputium (HP:0100587)3.19966211
10Aplastic anemia (HP:0001915)3.19726340
11Agnosia (HP:0010524)3.15870052
12Breast hypoplasia (HP:0003187)3.15383791
13Meckel diverticulum (HP:0002245)3.13901379
14Oral leukoplakia (HP:0002745)3.12805566
15Patellar aplasia (HP:0006443)3.06149488
16Colon cancer (HP:0003003)3.04925209
17Myelodysplasia (HP:0002863)3.04431962
18Acute necrotizing encephalopathy (HP:0006965)3.01026016
19Abnormality of the ileum (HP:0001549)3.00007567
20IgM deficiency (HP:0002850)2.92257705
21Acute encephalopathy (HP:0006846)2.89078916
22Increased hepatocellular lipid droplets (HP:0006565)2.88975868
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.86052361
24Aplasia/Hypoplasia of the patella (HP:0006498)2.83306510
25Thrombocytosis (HP:0001894)2.82164833
26Medulloblastoma (HP:0002885)2.75749609
2711 pairs of ribs (HP:0000878)2.73382759
28Pallor (HP:0000980)2.69757839
29Abnormal mitochondria in muscle tissue (HP:0008316)2.67647817
30Bone marrow hypocellularity (HP:0005528)2.67442504
31Duodenal stenosis (HP:0100867)2.67128145
32Small intestinal stenosis (HP:0012848)2.67128145
33Macrocytic anemia (HP:0001972)2.62305575
34Increased CSF lactate (HP:0002490)2.62139664
35Abnormal lung lobation (HP:0002101)2.55912072
36Selective tooth agenesis (HP:0001592)2.54920827
37Lipid accumulation in hepatocytes (HP:0006561)2.53841125
38Mitochondrial inheritance (HP:0001427)2.53491771
39Rough bone trabeculation (HP:0100670)2.53423777
40Absent thumb (HP:0009777)2.51794770
41Lymphoma (HP:0002665)2.49925797
42Ependymoma (HP:0002888)2.46927248
43Premature graying of hair (HP:0002216)2.44813633
44Progressive macrocephaly (HP:0004481)2.43063129
45Microretrognathia (HP:0000308)2.38615105
46Microvesicular hepatic steatosis (HP:0001414)2.34892931
47Type I transferrin isoform profile (HP:0003642)2.34511203
48Cerebral hypomyelination (HP:0006808)2.30623129
49Carpal bone hypoplasia (HP:0001498)2.29775259
50Abnormality of methionine metabolism (HP:0010901)2.29733114
51Amaurosis fugax (HP:0100576)2.28299958
52Sloping forehead (HP:0000340)2.27790006
53Impulsivity (HP:0100710)2.25302799
54Ectopic kidney (HP:0000086)2.21107148
55Cerebral edema (HP:0002181)2.20614667
56Cellular immunodeficiency (HP:0005374)2.20530714
57Basal cell carcinoma (HP:0002671)2.18843268
58Cleft eyelid (HP:0000625)2.18800654
59Hepatocellular necrosis (HP:0001404)2.18726031
60Multiple enchondromatosis (HP:0005701)2.17419000
61Abnormality of the duodenum (HP:0002246)2.16493709
62Increased serum lactate (HP:0002151)2.16039955
63Clubbing of toes (HP:0100760)2.15316691
64Optic nerve coloboma (HP:0000588)2.12208025
65Abnormality of the heme biosynthetic pathway (HP:0010472)2.11170203
66Neoplasm of the pancreas (HP:0002894)2.09217826
67Abnormality of T cells (HP:0002843)2.08971234
68Increased serum pyruvate (HP:0003542)2.08847370
69Tracheoesophageal fistula (HP:0002575)2.07841023
70Duplicated collecting system (HP:0000081)2.07640017
71Cortical dysplasia (HP:0002539)2.07361753
72Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07284736
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06182317
74Abnormal number of incisors (HP:0011064)2.06030971
75Recurrent abscess formation (HP:0002722)2.05670438
76Supernumerary spleens (HP:0009799)2.05356067
77Abnormality of T cell physiology (HP:0011840)2.04227228
78* Degeneration of anterior horn cells (HP:0002398)2.03307734
79* Abnormality of the anterior horn cell (HP:0006802)2.03307734
80Recurrent viral infections (HP:0004429)2.02679379
81Pulmonary fibrosis (HP:0002206)2.02420888
82IgG deficiency (HP:0004315)2.01113665
83Pancytopenia (HP:0001876)1.99954798
84Hepatic necrosis (HP:0002605)1.98165528
85Abnormality of glycolysis (HP:0004366)1.97664169
86Abnormality of the carotid arteries (HP:0005344)1.96799960
87Abnormality of DNA repair (HP:0003254)1.96465152
88Triphalangeal thumb (HP:0001199)1.96248027
89Rhabdomyosarcoma (HP:0002859)1.95868959
90Poor head control (HP:0002421)1.95791840
91Renal Fanconi syndrome (HP:0001994)1.95265195
92Absent radius (HP:0003974)1.94237469
93Methylmalonic acidemia (HP:0002912)1.93938714
94Nephroblastoma (Wilms tumor) (HP:0002667)1.91683119
95Combined immunodeficiency (HP:0005387)1.91465535
96T lymphocytopenia (HP:0005403)1.89985784
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89874398
98Horseshoe kidney (HP:0000085)1.89267121
99Petechiae (HP:0000967)1.88221113
100Abnormality of the renal collecting system (HP:0004742)1.87776392
101Pancreatic islet-cell hyperplasia (HP:0004510)1.87688523
102Volvulus (HP:0002580)1.87275314
103Overlapping toe (HP:0001845)1.87209121
104Acute myeloid leukemia (HP:0004808)1.85683176
105Cafe-au-lait spot (HP:0000957)1.85460801
106Embryonal neoplasm (HP:0002898)1.84917827
107Atresia of the external auditory canal (HP:0000413)1.84644158
108Abnormality of serum amino acid levels (HP:0003112)1.84294957
109Acute lymphatic leukemia (HP:0006721)1.83847953
110Lactic acidosis (HP:0003128)1.83741549
111Chronic otitis media (HP:0000389)1.83294984
112Abnormal trabecular bone morphology (HP:0100671)1.82966126
113Elevated erythrocyte sedimentation rate (HP:0003565)1.82917517
114Increased nuchal translucency (HP:0010880)1.82698496
115Chronic obstructive pulmonary disease (HP:0006510)1.82341526
116Obstructive lung disease (HP:0006536)1.82341526
117Respiratory difficulties (HP:0002880)1.80935674
118Abnormality of the septum pellucidum (HP:0007375)1.80676272
119Poikiloderma (HP:0001029)1.80526805
120Neoplasm of the colon (HP:0100273)1.79925675
121Abnormality of B cell number (HP:0010975)1.78793440
122B lymphocytopenia (HP:0010976)1.78793440
123Severe combined immunodeficiency (HP:0004430)1.78365291
1243-Methylglutaconic aciduria (HP:0003535)1.77178461
125Slender long bone (HP:0003100)1.76992521
126Septo-optic dysplasia (HP:0100842)1.76836497
127Choanal atresia (HP:0000453)1.76610346
128Embryonal renal neoplasm (HP:0011794)1.76339061
129Aplasia involving forearm bones (HP:0009822)1.76175787
130Absent forearm bone (HP:0003953)1.76175787
131Hyperglycinemia (HP:0002154)1.76051626
132Abnormality of T cell number (HP:0011839)1.74784403
133Ovarian neoplasm (HP:0100615)1.74709434
134Absent septum pellucidum (HP:0001331)1.74630313
135Leukodystrophy (HP:0002415)1.74618230
136Abnormal glycosylation (HP:0012345)1.74564542
137Megaloblastic anemia (HP:0001889)1.74475514
138Reduced antithrombin III activity (HP:0001976)1.73281130
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.72601236
140Glioma (HP:0009733)1.72235980
141Abnormal protein glycosylation (HP:0012346)1.71718447
142Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71718447
143Abnormal protein N-linked glycosylation (HP:0012347)1.71718447
144Short thumb (HP:0009778)1.71393282
145Gonadotropin excess (HP:0000837)1.70894056
146Neoplasm of the adrenal gland (HP:0100631)1.66464788
147Hypoplastic pelvis (HP:0008839)1.65987862
148Oligodactyly (hands) (HP:0001180)1.65766989
149Arteriovenous malformation (HP:0100026)1.65590953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.74040361
2CDC74.29224916
3WEE13.99269861
4EIF2AK13.35533768
5VRK23.07553507
6STK162.82733666
7NEK22.55294704
8SRPK12.53834079
9EIF2AK32.17928713
10NUAK12.13313593
11PLK42.09147019
12TSSK62.01661702
13MAP4K12.01435531
14BRSK21.98455864
15MKNK11.91191356
16TTK1.90199413
17PASK1.85892247
18PLK11.85500422
19TLK11.80445281
20NME21.78525652
21ATR1.75508249
22RPS6KA41.73957399
23TAF11.70329937
24ACVR1B1.69953254
25NEK11.67407063
26TRIM281.63933276
27AURKB1.59950662
28TNIK1.57556539
29CCNB11.57036000
30IRAK41.51553963
31CDK71.49418809
32DYRK31.49332216
33NME11.41087789
34TESK21.39168710
35STK101.38584475
36MKNK21.35494897
37BRSK11.34937927
38* VRK11.32388523
39BMPR1B1.32329181
40TXK1.27341217
41CHEK21.25240437
42STK41.21468391
43WNK31.18044985
44FLT31.15866035
45CDK41.14311952
46RPS6KB21.14231333
47MAP3K81.13902506
48CHEK11.11820196
49* PLK31.11459774
50CDK81.10678319
51BLK1.10117494
52MST41.08158609
53ZAK1.08145220
54TGFBR11.05468381
55PNCK1.04940478
56AURKA1.03688017
57PLK21.01826286
58ZAP701.00114796
59PAK40.98110543
60TEC0.97401583
61EIF2AK20.97046071
62KIT0.96420972
63CLK10.94651822
64BTK0.93153926
65PIM10.92068245
66EEF2K0.91464737
67MAP2K30.91117193
68MAP4K20.83052344
69ATM0.80270331
70CDK120.79632243
71JAK30.77906535
72PIM20.76135825
73CSF1R0.75969246
74CDK20.72782817
75NEK90.72181284
76CSNK2A10.70266922
77PDK20.63844956
78BCR0.62699651
79BRD40.62069019
80YES10.61906851
81CSNK2A20.61799532
82SCYL20.61136350
83DYRK20.60426916
84SYK0.59984150
85CDK60.58963497
86TYK20.58902750
87RPS6KA50.58783587
88LRRK20.56807476
89LYN0.55445987
90ERBB30.55215591
91CDK10.54222768
92KDR0.51828729
93BRAF0.51667350
94CSNK1G10.51371616
95CDK190.51138241
96PAK10.48548168
97GRK60.48523203
98MELK0.47040616
99CDK30.46174782
100TAOK30.44876502
101MAP3K40.42662920
102CSNK1E0.42543036
103MAP3K140.42168735
104IKBKB0.41965508
105LATS10.41795968
106BCKDK0.41097044
107CSNK1G30.40436059
108PRKDC0.37443781
109MAP3K100.36332624
110LCK0.35809290
111ALK0.35666038
112IRAK30.35261025
113MAPKAPK20.33545320
114CSNK1G20.31707672
115ITK0.30887728
116RPS6KA60.29811515
117PBK0.29667160
118DAPK10.27930287
119TESK10.26766901
120STK30.26591804
121CHUK0.26323042
122MARK30.26010319
123FGFR10.25821209
124NLK0.25539118
125RPS6KC10.25343116
126RPS6KL10.25343116
127EPHA20.24864497
128CDK180.24597120
129CDK140.22587737
130OXSR10.22470698
131MINK10.22251323
132CSNK1A1L0.21768256
133STK38L0.21264717
134CDK150.21179217
135CDK11A0.20771731
136PRKCI0.20107787

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.32303773
2Mismatch repair_Homo sapiens_hsa034304.45005631
3Base excision repair_Homo sapiens_hsa034103.36917554
4Homologous recombination_Homo sapiens_hsa034403.21426869
5Ribosome_Homo sapiens_hsa030103.21271354
6Spliceosome_Homo sapiens_hsa030403.17461074
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17073261
8Proteasome_Homo sapiens_hsa030503.04697759
9RNA polymerase_Homo sapiens_hsa030203.04109632
10Nucleotide excision repair_Homo sapiens_hsa034202.87130942
11RNA transport_Homo sapiens_hsa030132.74222839
12Cell cycle_Homo sapiens_hsa041102.70221469
13Pyrimidine metabolism_Homo sapiens_hsa002402.42365603
14Fanconi anemia pathway_Homo sapiens_hsa034602.36349385
15One carbon pool by folate_Homo sapiens_hsa006702.35818955
16Non-homologous end-joining_Homo sapiens_hsa034502.18123735
17Oxidative phosphorylation_Homo sapiens_hsa001902.01172516
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00831347
19RNA degradation_Homo sapiens_hsa030181.91500840
20Basal transcription factors_Homo sapiens_hsa030221.81361154
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52775258
22p53 signaling pathway_Homo sapiens_hsa041151.49945695
23mRNA surveillance pathway_Homo sapiens_hsa030151.45063993
24Protein export_Homo sapiens_hsa030601.40120163
25Antigen processing and presentation_Homo sapiens_hsa046121.33100443
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31498863
27Purine metabolism_Homo sapiens_hsa002301.30011512
28Propanoate metabolism_Homo sapiens_hsa006401.29520278
29Epstein-Barr virus infection_Homo sapiens_hsa051691.25549020
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24449512
31Pyruvate metabolism_Homo sapiens_hsa006201.23362892
32Primary immunodeficiency_Homo sapiens_hsa053401.22443444
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20911353
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17649079
35Herpes simplex infection_Homo sapiens_hsa051681.17515448
36Systemic lupus erythematosus_Homo sapiens_hsa053221.09502910
37Alzheimers disease_Homo sapiens_hsa050101.06769607
38Steroid biosynthesis_Homo sapiens_hsa001000.92660052
39Viral carcinogenesis_Homo sapiens_hsa052030.89634467
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88837261
41Fatty acid elongation_Homo sapiens_hsa000620.88271721
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82972173
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81868076
44Oocyte meiosis_Homo sapiens_hsa041140.81672231
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81382348
46Legionellosis_Homo sapiens_hsa051340.80868895
47Carbon metabolism_Homo sapiens_hsa012000.80771801
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80297721
49Measles_Homo sapiens_hsa051620.78524487
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75883366
51HTLV-I infection_Homo sapiens_hsa051660.74652536
52Vitamin B6 metabolism_Homo sapiens_hsa007500.73383928
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72486906
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71024691
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70912936
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.69926706
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.69658547
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67655048
59Hematopoietic cell lineage_Homo sapiens_hsa046400.67431347
60Folate biosynthesis_Homo sapiens_hsa007900.66907862
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63684633
62N-Glycan biosynthesis_Homo sapiens_hsa005100.62221318
63Leishmaniasis_Homo sapiens_hsa051400.61123189
64Pentose phosphate pathway_Homo sapiens_hsa000300.60585483
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58392928
66Apoptosis_Homo sapiens_hsa042100.54624051
67Shigellosis_Homo sapiens_hsa051310.54351658
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53520772
69Metabolic pathways_Homo sapiens_hsa011000.53309058
70Hepatitis B_Homo sapiens_hsa051610.52766775
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52106537
72Allograft rejection_Homo sapiens_hsa053300.51423710
73Thyroid cancer_Homo sapiens_hsa052160.51366528
74Selenocompound metabolism_Homo sapiens_hsa004500.50963273
75Small cell lung cancer_Homo sapiens_hsa052220.50036612
76Influenza A_Homo sapiens_hsa051640.49475275
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48437683
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.48155279
79Asthma_Homo sapiens_hsa053100.46348288
80Butanoate metabolism_Homo sapiens_hsa006500.42875232
81Huntingtons disease_Homo sapiens_hsa050160.42854219
82Cardiac muscle contraction_Homo sapiens_hsa042600.42146687
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41695743
84MicroRNAs in cancer_Homo sapiens_hsa052060.41484834
85Graft-versus-host disease_Homo sapiens_hsa053320.41009731
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40700719
87Peroxisome_Homo sapiens_hsa041460.39591385
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.39272462
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38390514
90Alcoholism_Homo sapiens_hsa050340.37566469
91B cell receptor signaling pathway_Homo sapiens_hsa046620.34202197
92Viral myocarditis_Homo sapiens_hsa054160.33796773
93Biosynthesis of amino acids_Homo sapiens_hsa012300.32488400
94Other glycan degradation_Homo sapiens_hsa005110.30846347
95Glutathione metabolism_Homo sapiens_hsa004800.29702344
96Parkinsons disease_Homo sapiens_hsa050120.28513315
97Fatty acid metabolism_Homo sapiens_hsa012120.28433970
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27723167
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27629491
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27235156
101Chronic myeloid leukemia_Homo sapiens_hsa052200.26962903
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25849072
103Colorectal cancer_Homo sapiens_hsa052100.25613031
104TGF-beta signaling pathway_Homo sapiens_hsa043500.25307013
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.24699005
106Acute myeloid leukemia_Homo sapiens_hsa052210.23928570
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.23246717
108Type I diabetes mellitus_Homo sapiens_hsa049400.23020781
109T cell receptor signaling pathway_Homo sapiens_hsa046600.22098121
110Autoimmune thyroid disease_Homo sapiens_hsa053200.21294556
111Pertussis_Homo sapiens_hsa051330.20928644
112Lysine degradation_Homo sapiens_hsa003100.20296378
113Sulfur relay system_Homo sapiens_hsa041220.19085369
114Phototransduction_Homo sapiens_hsa047440.18855252
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.18597593
116Toxoplasmosis_Homo sapiens_hsa051450.18312961
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17910202
118Wnt signaling pathway_Homo sapiens_hsa043100.17903423
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17809738
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17239760
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16973341
122Fatty acid degradation_Homo sapiens_hsa000710.16476242
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16428817
124Notch signaling pathway_Homo sapiens_hsa043300.16242260
125Regulation of autophagy_Homo sapiens_hsa041400.16108407
126Basal cell carcinoma_Homo sapiens_hsa052170.15310987
127Galactose metabolism_Homo sapiens_hsa000520.15257945
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15079841
129Pathways in cancer_Homo sapiens_hsa052000.15045508
130Osteoclast differentiation_Homo sapiens_hsa043800.14644134
131Olfactory transduction_Homo sapiens_hsa047400.14502847
132Arachidonic acid metabolism_Homo sapiens_hsa005900.13707620
133Tuberculosis_Homo sapiens_hsa051520.12900820
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07461095
135Nitrogen metabolism_Homo sapiens_hsa009100.07414588
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05979925
137Hippo signaling pathway_Homo sapiens_hsa043900.04913981
138Arginine and proline metabolism_Homo sapiens_hsa003300.04808504
139Caffeine metabolism_Homo sapiens_hsa002320.04712207
140Hedgehog signaling pathway_Homo sapiens_hsa043400.04480262
141beta-Alanine metabolism_Homo sapiens_hsa004100.04247914
142Vitamin digestion and absorption_Homo sapiens_hsa049770.03155553
143Tryptophan metabolism_Homo sapiens_hsa00380-0.0073246
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0065574

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