VRK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71262534
2ribosome assembly (GO:0042255)4.31026875
3antigen processing and presentation of endogenous antigen (GO:0019883)4.23800846
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18636788
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18636788
6neutrophil activation involved in immune response (GO:0002283)3.79221523
7proteasome assembly (GO:0043248)3.73046602
8immunoglobulin mediated immune response (GO:0016064)3.70082400
9positive regulation of interferon-alpha production (GO:0032727)3.65510173
10ribosomal small subunit assembly (GO:0000028)3.45913538
11positive regulation of gamma-delta T cell activation (GO:0046645)3.45077088
12regulation of interferon-alpha production (GO:0032647)3.44848280
13cellular response to interferon-beta (GO:0035458)3.43096653
14B cell mediated immunity (GO:0019724)3.42620433
15NIK/NF-kappaB signaling (GO:0038061)3.37804348
16regulation of RIG-I signaling pathway (GO:0039535)3.30271472
17regulation of B cell receptor signaling pathway (GO:0050855)3.22230982
18natural killer cell mediated immunity (GO:0002228)3.20696134
19natural killer cell mediated cytotoxicity (GO:0042267)3.20696134
20modulation by symbiont of host immune response (GO:0052553)3.18316509
21positive regulation by symbiont of host defense response (GO:0052509)3.18316509
22modulation by symbiont of host defense response (GO:0052031)3.18316509
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18316509
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18316509
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.18316509
26response to interferon-beta (GO:0035456)3.17290837
27telomere maintenance via semi-conservative replication (GO:0032201)3.14636277
28defense response to protozoan (GO:0042832)3.14318651
29telomere maintenance via recombination (GO:0000722)3.14081417
30myeloid dendritic cell activation (GO:0001773)3.14054061
31regulation of interferon-beta biosynthetic process (GO:0045357)3.10106443
32negative regulation of phagocytosis (GO:0050765)3.09826984
33cellular response to type I interferon (GO:0071357)3.09040784
34type I interferon signaling pathway (GO:0060337)3.09040784
35response to type I interferon (GO:0034340)3.07722004
36cellular response to exogenous dsRNA (GO:0071360)2.99765652
37cellular response to zinc ion (GO:0071294)2.98944721
38synapsis (GO:0007129)2.98865821
39somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.97821319
40somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.97821319
41isotype switching (GO:0045190)2.97821319
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97093435
43DNA strand elongation involved in DNA replication (GO:0006271)2.96254986
44response to peptidoglycan (GO:0032494)2.94079991
45positive regulation of antigen processing and presentation (GO:0002579)2.90099589
46positive regulation of natural killer cell differentiation (GO:0032825)2.89800164
47folic acid-containing compound biosynthetic process (GO:0009396)2.89535132
48regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.89013891
49neutrophil activation (GO:0042119)2.88346623
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87079915
51positive regulation of B cell differentiation (GO:0045579)2.86773336
52DNA deamination (GO:0045006)2.86673763
53negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.85860656
54response to muramyl dipeptide (GO:0032495)2.85438819
55DNA strand elongation (GO:0022616)2.84415992
56CENP-A containing nucleosome assembly (GO:0034080)2.83513712
57Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82367608
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80688975
59mitotic G2 DNA damage checkpoint (GO:0007095)2.80421813
60mitotic recombination (GO:0006312)2.79803563
61positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.79463015
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78970448
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77671304
64DNA replication initiation (GO:0006270)2.76301847
65mitotic G2/M transition checkpoint (GO:0044818)2.76085261
66response to protozoan (GO:0001562)2.75649329
67myeloid dendritic cell differentiation (GO:0043011)2.73521682
68DNA double-strand break processing (GO:0000729)2.73290630
69rRNA modification (GO:0000154)2.73049897
70positive regulation of interferon-beta production (GO:0032728)2.72268679
71granulocyte activation (GO:0036230)2.72004063
72regulation of chronic inflammatory response (GO:0002676)2.71632205
73positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69532478
74IMP biosynthetic process (GO:0006188)2.69249462
75DNA catabolic process, exonucleolytic (GO:0000738)2.69013155
76purine nucleobase biosynthetic process (GO:0009113)2.68976190
77somatic hypermutation of immunoglobulin genes (GO:0016446)2.68061586
78somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68061586
79negative regulation of viral genome replication (GO:0045071)2.65933247
80interferon-gamma-mediated signaling pathway (GO:0060333)2.65684168
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65099968
82negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63860674
83negative regulation of ligase activity (GO:0051352)2.63860674
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62291151
85chromatin remodeling at centromere (GO:0031055)2.62230429
86regulation of B cell differentiation (GO:0045577)2.60797138
87transcription from mitochondrial promoter (GO:0006390)2.60617876
88T cell migration (GO:0072678)2.60148052
89negative regulation of DNA-dependent DNA replication (GO:2000104)2.59382058
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.58725752
91T-helper 1 type immune response (GO:0042088)2.58459516
92negative thymic T cell selection (GO:0045060)2.58060912
93regulation of alpha-beta T cell proliferation (GO:0046640)2.57593367
94kinetochore organization (GO:0051383)2.57593361
95regulation of antigen processing and presentation (GO:0002577)2.57348046
96response to interferon-alpha (GO:0035455)2.57070646
97negative regulation of interleukin-12 production (GO:0032695)2.55182008
98nuclear pore complex assembly (GO:0051292)2.52163577
99positive regulation of interleukin-12 production (GO:0032735)2.50574620
100leukocyte aggregation (GO:0070486)2.50158069
101somatic recombination of immunoglobulin gene segments (GO:0016447)2.49413973
102histone mRNA metabolic process (GO:0008334)2.47799673
103positive regulation of defense response to virus by host (GO:0002230)2.47082263
104regulation of cellular amino acid metabolic process (GO:0006521)2.46615046
105negative T cell selection (GO:0043383)2.46267902
106positive regulation of alpha-beta T cell proliferation (GO:0046641)2.46201743
107negative regulation of thymocyte apoptotic process (GO:0070244)2.46134569
108regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.45258101
109positive regulation of interleukin-17 production (GO:0032740)2.45078821
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.44373788
111signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.44251535
112signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.44251535
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.44251535
114histone exchange (GO:0043486)2.43289107
115nucleotide-excision repair, DNA gap filling (GO:0006297)2.43224723
116lymphocyte mediated immunity (GO:0002449)2.42584044
117leukocyte mediated cytotoxicity (GO:0001909)2.42448570
118interferon-gamma production (GO:0032609)2.41955010
119regulation of dendritic cell antigen processing and presentation (GO:0002604)2.41903473
120IMP metabolic process (GO:0046040)2.41833402
121formation of translation preinitiation complex (GO:0001731)2.41784880
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.41689523
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.41689523
124nuclear pore organization (GO:0006999)2.41427567
125myeloid cell activation involved in immune response (GO:0002275)2.41304817
126rRNA methylation (GO:0031167)2.40568919
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.40389755
128positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.39737927
129regulation of meiosis I (GO:0060631)2.38277707
130cellular response to dsRNA (GO:0071359)2.38079643
131regulation of interleukin-12 biosynthetic process (GO:0045075)2.37601152
132dendritic cell chemotaxis (GO:0002407)2.37245585
133meiotic chromosome segregation (GO:0045132)2.37125752
134antigen processing and presentation via MHC class Ib (GO:0002475)2.36762112
135regulation of T-helper 1 cell differentiation (GO:0045625)2.36737929
136dendritic cell differentiation (GO:0097028)2.36304344
137positive regulation of isotype switching (GO:0045830)2.35731795
138pteridine-containing compound biosynthetic process (GO:0042559)2.35150038
139antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.34990752
140macrophage activation involved in immune response (GO:0002281)2.34400652
141telomere maintenance via telomere lengthening (GO:0010833)2.34159090
142signal transduction involved in DNA damage checkpoint (GO:0072422)2.33603064
143signal transduction involved in DNA integrity checkpoint (GO:0072401)2.33603064
144pseudouridine synthesis (GO:0001522)2.33524206
145positive regulation of ligase activity (GO:0051351)2.33043366
146regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.32906149
147regulation of activation of Janus kinase activity (GO:0010533)2.32763088
148deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.32620309
149mismatch repair (GO:0006298)2.32564630
150DNA replication checkpoint (GO:0000076)2.32220539
151somatic diversification of immunoglobulins (GO:0016445)2.32132768
152regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.30236398
153regulation of necroptotic process (GO:0060544)2.30052312
154telomere maintenance (GO:0000723)2.29449115
155B cell receptor signaling pathway (GO:0050853)2.28639460
156necroptotic process (GO:0070266)2.28329258
157mature B cell differentiation (GO:0002335)2.27870498
158positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.27842493
159regulation of gamma-delta T cell activation (GO:0046643)2.27569198
160mature B cell differentiation involved in immune response (GO:0002313)2.27534727
161respiratory burst (GO:0045730)2.27273233
162deoxyribonucleotide biosynthetic process (GO:0009263)2.27192628
163histone mRNA catabolic process (GO:0071044)2.27171079
164antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.26124289
165mitotic metaphase plate congression (GO:0007080)2.25886852
166signal transduction involved in cell cycle checkpoint (GO:0072395)2.25786559
167response to X-ray (GO:0010165)2.25686963
168hepatocyte apoptotic process (GO:0097284)2.25200109
169nucleobase biosynthetic process (GO:0046112)2.24873396
170maturation of 5.8S rRNA (GO:0000460)2.24344177
171tryptophan metabolic process (GO:0006568)2.24088317
172B cell activation involved in immune response (GO:0002312)2.19800789
173DNA ligation (GO:0006266)2.19203994
174regulation of helicase activity (GO:0051095)2.18379292
175prenylation (GO:0097354)2.17671508
176protein prenylation (GO:0018342)2.17671508
177regulation of translational termination (GO:0006449)2.17326538
178mitochondrial RNA metabolic process (GO:0000959)2.17100082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.03641378
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.74444284
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.15604051
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.70605778
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.14295963
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.11585143
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.87902021
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86741051
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.82146825
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65366299
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.63884695
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.54704683
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.54235799
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.41207053
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37096386
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36126606
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32147410
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30541718
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29978290
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25207037
21SPI1_23547873_ChIP-Seq_NB4_Human2.17984522
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16686413
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.11246261
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08275804
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01740617
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98128683
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.95273223
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87793404
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81005832
30SCL_19346495_ChIP-Seq_HPC-7_Human1.80804941
31MYB_26560356_Chip-Seq_TH2_Human1.80527503
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79377374
33GATA1_22025678_ChIP-Seq_K562_Human1.78469805
34* VDR_23849224_ChIP-Seq_CD4+_Human1.77816188
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76705299
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73847198
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72278985
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.69856169
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69781467
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61402325
41ELK1_19687146_ChIP-ChIP_HELA_Human1.61271109
42MYB_26560356_Chip-Seq_TH1_Human1.61095192
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.59024966
44VDR_21846776_ChIP-Seq_THP-1_Human1.58904642
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57528793
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55871502
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54125974
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53600920
49MAF_26560356_Chip-Seq_TH1_Human1.53032123
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51494362
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49065552
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48934572
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.45920447
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42721256
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41829156
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41321987
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.38819077
58* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38285023
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.38199034
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37708825
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36967448
62MYC_22102868_ChIP-Seq_BL_Human1.36695019
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.35668000
64FOXP3_21729870_ChIP-Seq_TREG_Human1.35342779
65VDR_24763502_ChIP-Seq_THP-1_Human1.35094278
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33270326
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.30170936
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29026801
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27036312
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.25925362
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25795113
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21404504
73XRN2_22483619_ChIP-Seq_HELA_Human1.20982836
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20393754
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19588197
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18920811
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18642740
78DCP1A_22483619_ChIP-Seq_HELA_Human1.17623969
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16384311
80AR_21909140_ChIP-Seq_LNCAP_Human1.15071750
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14906382
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14753096
83* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14376929
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12538420
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11973164
86RUNX_20019798_ChIP-Seq_JUKART_Human1.11136711
87UTX_26944678_Chip-Seq_JUKART_Human1.10618850
88PU_27001747_Chip-Seq_BMDM_Mouse1.09281803
89CIITA_25753668_ChIP-Seq_RAJI_Human1.07856897
90TFEB_21752829_ChIP-Seq_HELA_Human1.07691960
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07124942
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06416793
93* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06002762
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05699786
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05445265
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05193160
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03833518
98MYC_18940864_ChIP-ChIP_HL60_Human1.03278539
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02098766
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00431621
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99809896
102PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99619243
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99499730
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98927208
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97759739
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97677817
107GABP_19822575_ChIP-Seq_HepG2_Human0.95240969
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94699921
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94662107
110MAF_26560356_Chip-Seq_TH2_Human0.94113535
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93982378
112GATA3_27048872_Chip-Seq_THYMUS_Human0.93043021
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92418536
114GATA3_26560356_Chip-Seq_TH2_Human0.90796124
115MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90662352
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90134277
117* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90066568
118EWS_26573619_Chip-Seq_HEK293_Human0.89590962
119CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88696037
120SPI1_23127762_ChIP-Seq_K562_Human0.87619134
121VDR_22108803_ChIP-Seq_LS180_Human0.87433952
122* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86111422
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85992829
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.85103624
125SALL4_22934838_ChIP-ChIP_CD34+_Human0.84454006
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84236644
127ELF5_23300383_ChIP-Seq_T47D_Human0.81141465
128TTF2_22483619_ChIP-Seq_HELA_Human0.80511931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.51704238
2MP0000685_abnormal_immune_system3.17055753
3MP0003806_abnormal_nucleotide_metabolis3.15978016
4MP0009785_altered_susceptibility_to2.97591434
5MP0005671_abnormal_response_to2.93194605
6MP0002396_abnormal_hematopoietic_system2.82415638
7MP0002148_abnormal_hypersensitivity_rea2.76045489
8MP0003436_decreased_susceptibility_to2.69167464
9MP0001800_abnormal_humoral_immune2.58925377
10MP0005387_immune_system_phenotype2.57725016
11MP0001790_abnormal_immune_system2.57725016
12MP0005000_abnormal_immune_tolerance2.51921959
13MP0005025_abnormal_response_to2.50379905
14MP0002452_abnormal_antigen_presenting2.46335833
15MP0002166_altered_tumor_susceptibility2.43486786
16MP0003763_abnormal_thymus_physiology2.36629567
17MP0002723_abnormal_immune_serum2.34706962
18MP0002419_abnormal_innate_immunity2.32337407
19MP0001819_abnormal_immune_cell2.26889792
20MP0002420_abnormal_adaptive_immunity2.26023425
21MP0003693_abnormal_embryo_hatching2.18025634
22MP0002006_tumorigenesis2.15924504
23MP0002398_abnormal_bone_marrow2.12883068
24MP0010094_abnormal_chromosome_stability2.05744471
25MP0001853_heart_inflammation2.01850061
26MP0006082_CNS_inflammation1.94145403
27MP0000716_abnormal_immune_system1.88858122
28MP0003111_abnormal_nucleus_morphology1.83233348
29MP0008057_abnormal_DNA_replication1.82677522
30MP0003786_premature_aging1.82230002
31MP0003077_abnormal_cell_cycle1.81382253
32MP0000689_abnormal_spleen_morphology1.80404324
33MP0009333_abnormal_splenocyte_physiolog1.79566490
34MP0005464_abnormal_platelet_physiology1.78238198
35MP0002405_respiratory_system_inflammati1.76805922
36MP0001545_abnormal_hematopoietic_system1.72478687
37MP0005397_hematopoietic_system_phenotyp1.72478687
38MP0002722_abnormal_immune_system1.72417780
39MP0003724_increased_susceptibility_to1.68543649
40MP0002429_abnormal_blood_cell1.67738033
41MP0004808_abnormal_hematopoietic_stem1.66718057
42MP0000490_abnormal_crypts_of1.64159986
43MP0008007_abnormal_cellular_replicative1.60059048
44MP0010155_abnormal_intestine_physiology1.57172175
45MP0001845_abnormal_inflammatory_respons1.51983350
46MP0003941_abnormal_skin_development1.49458708
47MP0004510_myositis1.48691034
48MP0005058_abnormal_lysosome_morphology1.46238111
49MP0005174_abnormal_tail_pigmentation1.45773849
50MP0010307_abnormal_tumor_latency1.44028486
51MP0003718_maternal_effect1.43785902
52MP0004957_abnormal_blastocyst_morpholog1.41319467
53MP0008058_abnormal_DNA_repair1.35979950
54MP0000703_abnormal_thymus_morphology1.35399471
55MP0008877_abnormal_DNA_methylation1.29260200
56MP0003186_abnormal_redox_activity1.28133756
57MP0004947_skin_inflammation1.27957278
58MP0008469_abnormal_protein_level1.26791246
59MP0001873_stomach_inflammation1.26272490
60MP0002163_abnormal_gland_morphology1.25819690
61MP0005310_abnormal_salivary_gland1.25291215
62MP0000858_altered_metastatic_potential1.23931063
63MP0003950_abnormal_plasma_membrane1.23042025
64MP0010352_gastrointestinal_tract_polyps1.21403662
65MP0006036_abnormal_mitochondrial_physio1.20739714
66MP0000015_abnormal_ear_pigmentation1.20160737
67MP0001661_extended_life_span1.20122724
68MP0003303_peritoneal_inflammation1.19078511
69MP0001533_abnormal_skeleton_physiology1.17169838
70MP0003448_altered_tumor_morphology1.09852180
71MP0002019_abnormal_tumor_incidence1.09337735
72MP0003656_abnormal_erythrocyte_physiolo1.08934529
73MP0008260_abnormal_autophagy1.08812253
74MP0009764_decreased_sensitivity_to1.08401935
75MP0006035_abnormal_mitochondrial_morpho1.08224127
76MP0002009_preneoplasia1.06794957
77MP0002877_abnormal_melanocyte_morpholog1.06009996
78MP0000372_irregular_coat_pigmentation1.01427296
79MP0000343_altered_response_to1.01303799
80MP0002095_abnormal_skin_pigmentation1.01209940
81MP0002138_abnormal_hepatobiliary_system0.99473526
82MP0002132_abnormal_respiratory_system0.98937609
83MP0005167_abnormal_blood-brain_barrier0.97707234
84MP0000358_abnormal_cell_content/0.96961848
85MP0000465_gastrointestinal_hemorrhage0.95526679
86MP0005075_abnormal_melanosome_morpholog0.93958760
87MP0006054_spinal_hemorrhage0.93035830
88MP0001348_abnormal_lacrimal_gland0.93018023
89MP0003172_abnormal_lysosome_physiology0.90366388
90MP0002254_reproductive_system_inflammat0.89992276
91MP0000313_abnormal_cell_death0.89804195
92MP0008004_abnormal_stomach_pH0.86186483
93MP0004084_abnormal_cardiac_muscle0.85861125
94MP0009763_increased_sensitivity_to0.81908110
95MP0004782_abnormal_surfactant_physiolog0.80803285
96MP0001191_abnormal_skin_condition0.80431297
97MP0002837_dystrophic_cardiac_calcinosis0.79988609
98MP0005451_abnormal_body_composition0.79444921
99MP0002933_joint_inflammation0.79172222
100MP0005165_increased_susceptibility_to0.79055632
101MP0000569_abnormal_digit_pigmentation0.78819220
102MP0001730_embryonic_growth_arrest0.78499467
103MP0003195_calcinosis0.78341590
104MP0003943_abnormal_hepatobiliary_system0.77809430
105MP0003828_pulmonary_edema0.76877310
106MP0005410_abnormal_fertilization0.76173724
107MP0003252_abnormal_bile_duct0.76029919
108MP0002277_abnormal_respiratory_mucosa0.75385128
109MP0000350_abnormal_cell_proliferation0.74749168
110MP0010678_abnormal_skin_adnexa0.74294847
111MP0008873_increased_physiological_sensi0.73529440
112MP0003866_abnormal_defecation0.73014770
113MP0004215_abnormal_myocardial_fiber0.71896630
114MP0001346_abnormal_lacrimal_gland0.71852266
115MP0009278_abnormal_bone_marrow0.71307532
116MP0003566_abnormal_cell_adhesion0.67625431
117MP0009840_abnormal_foam_cell0.66418695
118MP0005023_abnormal_wound_healing0.66100436
119MP0009697_abnormal_copulation0.63359423
120MP0003191_abnormal_cellular_cholesterol0.61566255
121MP0004147_increased_porphyrin_level0.58938447
122MP0000371_diluted_coat_color0.56716291
123MP0008932_abnormal_embryonic_tissue0.56652443
124MP0000767_abnormal_smooth_muscle0.56325919
125MP0000598_abnormal_liver_morphology0.55394374
126MP0005076_abnormal_cell_differentiation0.55001068
127MP0005390_skeleton_phenotype0.54967344

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.96888695
2Recurrent bacterial skin infections (HP:0005406)4.68378520
3Elevated erythrocyte sedimentation rate (HP:0003565)4.30806123
4Myositis (HP:0100614)4.29588399
5Eczematoid dermatitis (HP:0000976)4.19233473
6Autoimmune thrombocytopenia (HP:0001973)3.96927394
7Recurrent viral infections (HP:0004429)3.62708304
8Birth length less than 3rd percentile (HP:0003561)3.56808273
9Thrombocytosis (HP:0001894)3.52908110
10Recurrent fungal infections (HP:0002841)3.51867170
11Chronic otitis media (HP:0000389)3.42682891
12Optic neuritis (HP:0100653)3.31674540
13Retrobulbar optic neuritis (HP:0100654)3.31674540
14IgM deficiency (HP:0002850)3.23446686
15Increased IgM level (HP:0003496)3.20657268
16Recurrent skin infections (HP:0001581)3.14389839
17Orchitis (HP:0100796)3.13162811
18Recurrent bronchitis (HP:0002837)3.11138259
19Mediastinal lymphadenopathy (HP:0100721)3.07339342
20Abnormality of macrophages (HP:0004311)3.06489463
21Recurrent gram-negative bacterial infections (HP:0005420)3.05682993
22Abnormality of T cell number (HP:0011839)2.90513277
23Petechiae (HP:0000967)2.88255959
24Vasculitis (HP:0002633)2.87384969
25Abnormality of T cell physiology (HP:0011840)2.86482223
26Autoimmune hemolytic anemia (HP:0001890)2.79714113
27Periodontitis (HP:0000704)2.79483731
28Abnormality of T cells (HP:0002843)2.78097567
29Chromsome breakage (HP:0040012)2.75703622
30Eosinophilia (HP:0001880)2.75604637
31Abnormality of methionine metabolism (HP:0010901)2.74674588
32IgG deficiency (HP:0004315)2.73209821
33Granulocytopenia (HP:0001913)2.71217221
34Chronic mucocutaneous candidiasis (HP:0002728)2.66950613
35Recurrent cutaneous fungal infections (HP:0011370)2.66950613
36Type I transferrin isoform profile (HP:0003642)2.66865107
37Meningitis (HP:0001287)2.65299433
38Cellulitis (HP:0100658)2.59160649
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.58387044
40Keratoconjunctivitis sicca (HP:0001097)2.57175132
41Reticulocytopenia (HP:0001896)2.57048871
42Agammaglobulinemia (HP:0004432)2.54699083
43Thyroiditis (HP:0100646)2.54226637
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.53286855
45Hypergammaglobulinemia (HP:0010702)2.52489788
46Increased hepatocellular lipid droplets (HP:0006565)2.50577653
47Leukocytosis (HP:0001974)2.50408203
48Obstructive lung disease (HP:0006536)2.50115482
49Chronic obstructive pulmonary disease (HP:0006510)2.50115482
50Pustule (HP:0200039)2.48257549
51T lymphocytopenia (HP:0005403)2.47960389
52Rhabdomyosarcoma (HP:0002859)2.47197546
53Keratoconjunctivitis (HP:0001096)2.46128320
54Abnormal number of erythroid precursors (HP:0012131)2.44290951
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42662720
56Hematochezia (HP:0002573)2.41005752
57Abnormality of eosinophils (HP:0001879)2.39968387
58Abnormality of the prostate (HP:0008775)2.38618710
59Panhypogammaglobulinemia (HP:0003139)2.37131141
60Increased CSF lactate (HP:0002490)2.36678560
61Prostate neoplasm (HP:0100787)2.35536197
62IgA deficiency (HP:0002720)2.35219494
63Lipid accumulation in hepatocytes (HP:0006561)2.35188376
64Abnormal spermatogenesis (HP:0008669)2.35164282
65Clubbing of toes (HP:0100760)2.34059157
66Recurrent pneumonia (HP:0006532)2.33875952
67Amaurosis fugax (HP:0100576)2.32644927
68Combined immunodeficiency (HP:0005387)2.31938477
69Exertional dyspnea (HP:0002875)2.30761464
70Severe combined immunodeficiency (HP:0004430)2.30607120
71Encephalitis (HP:0002383)2.30450453
72Abnormality of cells of the erythroid lineage (HP:0012130)2.30388449
73Spontaneous hematomas (HP:0007420)2.27594640
74Abnormal protein glycosylation (HP:0012346)2.27529209
75Abnormal glycosylation (HP:0012345)2.27529209
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27529209
77Abnormal protein N-linked glycosylation (HP:0012347)2.27529209
78B lymphocytopenia (HP:0010976)2.26800905
79Abnormality of B cell number (HP:0010975)2.26800905
80Poor head control (HP:0002421)2.25375121
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.25228465
82Abnormality of chromosome stability (HP:0003220)2.25183025
83Myelodysplasia (HP:0002863)2.24964510
84Lymphoma (HP:0002665)2.22660139
85Prolonged bleeding time (HP:0003010)2.22644652
86Oral leukoplakia (HP:0002745)2.22417470
87Basal ganglia calcification (HP:0002135)2.21386810
88Arterial thrombosis (HP:0004420)2.18740384
89Osteomyelitis (HP:0002754)2.18651463
90Gingivitis (HP:0000230)2.18240144
91Leukopenia (HP:0001882)2.13748651
92Aplastic anemia (HP:0001915)2.13587034
93Pulmonary fibrosis (HP:0002206)2.13585642
94Reduced antithrombin III activity (HP:0001976)2.11482300
95Lymphopenia (HP:0001888)2.10953840
96Urticaria (HP:0001025)2.10855396
97Stomatitis (HP:0010280)2.10449788
98Epistaxis (HP:0000421)2.10404441
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.10095923
100Recurrent lower respiratory tract infections (HP:0002783)2.09703443
101Syringomyelia (HP:0003396)2.09592316
102Spinal cord lesions (HP:0100561)2.09592316
103Abnormality of the preputium (HP:0100587)2.07527404
104Neutropenia (HP:0001875)2.07500649
105Mitochondrial inheritance (HP:0001427)2.06527295
106Acute necrotizing encephalopathy (HP:0006965)2.06301993
107Degeneration of anterior horn cells (HP:0002398)2.06119547
108Abnormality of the anterior horn cell (HP:0006802)2.06119547
109Biliary tract neoplasm (HP:0100574)2.05798219
110Chronic diarrhea (HP:0002028)2.05177243
111Pulmonary infiltrates (HP:0002113)2.04881437
112Osteolytic defects of the phalanges of the hand (HP:0009771)2.04506372
113Osteolytic defects of the hand bones (HP:0009699)2.04506372
114Meckel diverticulum (HP:0002245)2.04430582
115Volvulus (HP:0002580)2.02941360
116Abnormality of the fingertips (HP:0001211)2.02814004
117Duodenal stenosis (HP:0100867)2.01771391
118Small intestinal stenosis (HP:0012848)2.01771391
119Vacuolated lymphocytes (HP:0001922)2.01518593
120Agnosia (HP:0010524)1.98995445
121Nasal polyposis (HP:0100582)1.98978234
122Hypoplasia of the thymus (HP:0000778)1.98778264
123Entropion (HP:0000621)1.98756964
124Increased serum lactate (HP:0002151)1.98727813
125Pancreatic islet-cell hyperplasia (HP:0004510)1.96493813
126Abnormality of lateral ventricle (HP:0030047)1.95412662
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93845178
128Abnormality of alanine metabolism (HP:0010916)1.93845178
129Hyperalaninemia (HP:0003348)1.93845178
130Abnormality of the ileum (HP:0001549)1.91252313
131Azoospermia (HP:0000027)1.89827660
132Progressive macrocephaly (HP:0004481)1.88615669
133Xerostomia (HP:0000217)1.86752801
134Renal Fanconi syndrome (HP:0001994)1.86151230
135Palpitations (HP:0001962)1.85457751
136Gangrene (HP:0100758)1.84843020
137Congenital, generalized hypertrichosis (HP:0004540)1.84817480
138Hypoproteinemia (HP:0003075)1.84336895
139Dyschromatopsia (HP:0007641)1.83155237
140Acute encephalopathy (HP:0006846)1.82733123
141Abnormal mitochondria in muscle tissue (HP:0008316)1.82588971
142Respiratory difficulties (HP:0002880)1.81917774
143Anorexia (HP:0002039)1.81644574
144Cutaneous melanoma (HP:0012056)1.78220383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.26317948
2MAP4K13.11832863
3IRAK42.97359493
4TYK22.71406990
5TBK12.52262381
6IRAK32.32956871
7TXK2.29879815
8BUB12.23536613
9KIT2.22395299
10WEE12.19471518
11JAK32.15677129
12NME22.15058925
13IKBKE2.08050342
14IKBKB2.05346781
15EIF2AK11.92364002
16BLK1.78313766
17TRIM281.74002039
18CDC71.73260763
19TTK1.71526422
20RPS6KA41.71502517
21CSF1R1.70952178
22PIM21.69553485
23ZAP701.67603400
24NEK11.67410760
25BRSK21.63380408
26ACVR1B1.59021649
27BTK1.56940807
28VRK11.56701336
29STK101.54215583
30SYK1.50684127
31TEC1.50090583
32TLK11.48887253
33PIM11.42112489
34FLT31.41825149
35NEK21.41564855
36PIK3CG1.40144562
37TGFBR11.34605066
38STK161.33725579
39STK41.31412786
40CHUK1.30778102
41PLK41.29780309
42MKNK11.26863846
43VRK21.23280333
44ERBB31.23180175
45EIF2AK21.22262573
46JAK11.20870941
47SCYL21.14477024
48TGFBR21.14373690
49SRPK11.13167477
50ZAK1.12263976
51PDK21.11737691
52TAOK31.09580102
53SIK31.08784894
54PBK1.08396216
55MAP3K121.07205549
56CLK11.04190172
57MAPKAPK31.03231709
58ATR1.02626668
59KDR1.02066444
60MAP3K131.01899991
61MAP2K31.00327103
62LYN0.99905376
63LCK0.99824184
64STK240.96528576
65NLK0.95567675
66CDK40.91406522
67MST40.90382502
68RIPK40.88112408
69EIF2AK30.86382400
70NEK90.85048742
71NUAK10.84674774
72GRK70.82463608
73AURKB0.82258378
74MKNK20.79817021
75CDK60.77155556
76CSK0.76960033
77HCK0.76771475
78PLK10.75024063
79BRSK10.74709592
80CDK70.72482425
81BMPR20.70236787
82TRPM70.70025086
83FGR0.69574758
84CCNB10.67049194
85LRRK20.67041943
86ITK0.66838813
87RPS6KA50.65155774
88RPS6KB20.63976652
89PAK40.63595923
90FGFR30.63534505
91CDK80.63208038
92MST1R0.62133642
93MAP3K80.59322165
94BMPR1B0.59003788
95YES10.58329837
96FRK0.56601724
97TAF10.56551003
98PLK20.56237779
99MELK0.56104111
100DAPK10.55366299
101MATK0.53755537
102TESK20.52213448
103GRK60.51635221
104MAPKAPK20.51616385
105MAPK110.49695928
106DYRK30.49200464
107NME10.48988374
108MARK30.47506872
109BCR0.46388375
110IRAK10.46097044
111FGFR40.44794213
112JAK20.44515825
113ATM0.44035292
114MYLK0.44016867
115BCKDK0.43882296
116PASK0.43206576
117STK30.42692400
118PLK30.42241018
119TSSK60.41232759
120EGFR0.41074794
121ADRBK20.40214543
122CSNK2A10.40204130
123PRKCD0.39669672
124CHEK20.38358429
125TESK10.37974533
126PRKCQ0.37551185
127CHEK10.36945354
128OXSR10.36898106
129ABL10.35834204

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.44560634
2Mismatch repair_Homo sapiens_hsa034302.90041220
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.53161075
4Allograft rejection_Homo sapiens_hsa053302.51465095
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.36781005
6Primary immunodeficiency_Homo sapiens_hsa053402.36645582
7Base excision repair_Homo sapiens_hsa034102.27005968
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.25270268
9Leishmaniasis_Homo sapiens_hsa051402.25167889
10Proteasome_Homo sapiens_hsa030502.16445793
11Homologous recombination_Homo sapiens_hsa034402.08332306
12Measles_Homo sapiens_hsa051622.07507949
13Graft-versus-host disease_Homo sapiens_hsa053322.01322877
14Ribosome_Homo sapiens_hsa030101.97836324
15Herpes simplex infection_Homo sapiens_hsa051681.93626433
16Antigen processing and presentation_Homo sapiens_hsa046121.85695066
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85136819
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81944405
19Non-homologous end-joining_Homo sapiens_hsa034501.80198922
20One carbon pool by folate_Homo sapiens_hsa006701.74051876
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71959262
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67917457
23Nucleotide excision repair_Homo sapiens_hsa034201.62542363
24Cell cycle_Homo sapiens_hsa041101.58879163
25Legionellosis_Homo sapiens_hsa051341.58556935
26Influenza A_Homo sapiens_hsa051641.52031264
27Spliceosome_Homo sapiens_hsa030401.46593185
28p53 signaling pathway_Homo sapiens_hsa041151.43876729
29Hematopoietic cell lineage_Homo sapiens_hsa046401.43152682
30Osteoclast differentiation_Homo sapiens_hsa043801.42441987
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41877964
32Fanconi anemia pathway_Homo sapiens_hsa034601.40842141
33Autoimmune thyroid disease_Homo sapiens_hsa053201.39280365
34B cell receptor signaling pathway_Homo sapiens_hsa046621.36815136
35Pertussis_Homo sapiens_hsa051331.29816572
36Apoptosis_Homo sapiens_hsa042101.27666796
37Asthma_Homo sapiens_hsa053101.26504768
38Pyrimidine metabolism_Homo sapiens_hsa002401.25099790
39Malaria_Homo sapiens_hsa051441.24503216
40Shigellosis_Homo sapiens_hsa051311.22193683
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19408010
42Staphylococcus aureus infection_Homo sapiens_hsa051501.17115069
43Epstein-Barr virus infection_Homo sapiens_hsa051691.16657212
44TNF signaling pathway_Homo sapiens_hsa046681.16130868
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.16020319
46Toxoplasmosis_Homo sapiens_hsa051451.15901368
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11143197
48Viral myocarditis_Homo sapiens_hsa054161.08939268
49RNA transport_Homo sapiens_hsa030131.08900859
50RNA polymerase_Homo sapiens_hsa030201.05999391
51Hepatitis B_Homo sapiens_hsa051611.05724180
52Tuberculosis_Homo sapiens_hsa051521.01496496
53RNA degradation_Homo sapiens_hsa030180.96089639
54Systemic lupus erythematosus_Homo sapiens_hsa053220.95955757
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94995610
56Oxidative phosphorylation_Homo sapiens_hsa001900.94188389
57Viral carcinogenesis_Homo sapiens_hsa052030.88058920
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86542931
59Type I diabetes mellitus_Homo sapiens_hsa049400.85108610
60Protein export_Homo sapiens_hsa030600.84399615
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83925153
62Parkinsons disease_Homo sapiens_hsa050120.83205200
63Other glycan degradation_Homo sapiens_hsa005110.83015036
64T cell receptor signaling pathway_Homo sapiens_hsa046600.81986746
65Small cell lung cancer_Homo sapiens_hsa052220.81390845
66Glutathione metabolism_Homo sapiens_hsa004800.81136041
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79498849
68Salmonella infection_Homo sapiens_hsa051320.78102316
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75711233
70Basal transcription factors_Homo sapiens_hsa030220.72884925
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71659797
72Chemokine signaling pathway_Homo sapiens_hsa040620.69508358
73HTLV-I infection_Homo sapiens_hsa051660.68930058
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68151777
75Rheumatoid arthritis_Homo sapiens_hsa053230.67552000
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67406520
77Sulfur metabolism_Homo sapiens_hsa009200.66252965
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65904483
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.65087792
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64791646
81Hepatitis C_Homo sapiens_hsa051600.64730301
82Acute myeloid leukemia_Homo sapiens_hsa052210.63962001
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.62523285
84African trypanosomiasis_Homo sapiens_hsa051430.60800024
85Caffeine metabolism_Homo sapiens_hsa002320.59976426
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58980766
87Lysosome_Homo sapiens_hsa041420.58631520
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58109951
89Fatty acid elongation_Homo sapiens_hsa000620.56651174
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53619179
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.52978557
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52775705
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52696078
94Propanoate metabolism_Homo sapiens_hsa006400.51721962
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50817447
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49322716
97Folate biosynthesis_Homo sapiens_hsa007900.49073816
98Chronic myeloid leukemia_Homo sapiens_hsa052200.48657312
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48258005
100Phagosome_Homo sapiens_hsa041450.47206357
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46407694
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45613618
103Platelet activation_Homo sapiens_hsa046110.44587140
104Pancreatic cancer_Homo sapiens_hsa052120.44506729
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42638281
106Purine metabolism_Homo sapiens_hsa002300.42294830
107Pentose phosphate pathway_Homo sapiens_hsa000300.41962385
108Huntingtons disease_Homo sapiens_hsa050160.38766014
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37783258
110Arachidonic acid metabolism_Homo sapiens_hsa005900.37410957
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35514130
112MicroRNAs in cancer_Homo sapiens_hsa052060.35260603
113Vitamin B6 metabolism_Homo sapiens_hsa007500.32381613
114Alzheimers disease_Homo sapiens_hsa050100.31978867
115Selenocompound metabolism_Homo sapiens_hsa004500.31507623
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31299438
117Oocyte meiosis_Homo sapiens_hsa041140.31056184
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.31032113
119mRNA surveillance pathway_Homo sapiens_hsa030150.30746470
120Regulation of autophagy_Homo sapiens_hsa041400.30653664
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30577080
122Renin-angiotensin system_Homo sapiens_hsa046140.20372143

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