VRK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein polyglutamylation (GO:0018095)5.07309396
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.85661977
3positive regulation of gamma-delta T cell activation (GO:0046645)4.54387063
4behavioral response to nicotine (GO:0035095)4.50229162
5cytidine metabolic process (GO:0046087)4.49541576
6cytidine catabolic process (GO:0006216)4.49541576
7cytidine deamination (GO:0009972)4.49541576
8water-soluble vitamin biosynthetic process (GO:0042364)4.44106684
9regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.33262158
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16513474
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.16513474
12protein complex biogenesis (GO:0070271)4.12629476
13ribosomal small subunit assembly (GO:0000028)4.10144717
14platelet dense granule organization (GO:0060155)4.01699350
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.98444150
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.94726207
17antigen processing and presentation of endogenous antigen (GO:0019883)3.89503050
18response to pheromone (GO:0019236)3.82773008
19epithelial cilium movement (GO:0003351)3.82195733
20axoneme assembly (GO:0035082)3.81747155
21pyrimidine ribonucleoside catabolic process (GO:0046133)3.76894183
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.76175071
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.76175071
24NADH dehydrogenase complex assembly (GO:0010257)3.76175071
25defense response to protozoan (GO:0042832)3.69435645
26CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.66853709
27axonemal dynein complex assembly (GO:0070286)3.65480390
28mitochondrial respiratory chain complex assembly (GO:0033108)3.64804088
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.64592859
30phospholipid scrambling (GO:0017121)3.62846994
31DNA deamination (GO:0045006)3.58241956
32regulation of cilium movement (GO:0003352)3.56069373
33response to protozoan (GO:0001562)3.38953322
34interferon-gamma production (GO:0032609)3.36051519
35sperm motility (GO:0030317)3.32845705
36negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.27693443
37phosphatidylethanolamine biosynthetic process (GO:0006646)3.26984008
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.22244442
39regulation of B cell receptor signaling pathway (GO:0050855)3.22127073
40cilium or flagellum-dependent cell motility (GO:0001539)3.20344811
41piRNA metabolic process (GO:0034587)3.19363901
42preassembly of GPI anchor in ER membrane (GO:0016254)3.19189612
43cilium movement (GO:0003341)3.17248212
44regulation of isotype switching to IgG isotypes (GO:0048302)3.15856117
45antigen processing and presentation via MHC class Ib (GO:0002475)3.15582177
46sulfation (GO:0051923)3.14263086
47multicellular organism reproduction (GO:0032504)3.12062360
48regulation of gamma-delta T cell activation (GO:0046643)3.10039335
49T cell lineage commitment (GO:0002360)3.08736050
50phosphatidylethanolamine metabolic process (GO:0046337)3.05922551
51regulation of gamma-delta T cell differentiation (GO:0045586)3.05888370
52adaptation of signaling pathway (GO:0023058)3.05436399
53regulation of B cell differentiation (GO:0045577)3.02761441
54GPI anchor metabolic process (GO:0006505)3.01971371
55fucose catabolic process (GO:0019317)3.01409240
56L-fucose metabolic process (GO:0042354)3.01409240
57L-fucose catabolic process (GO:0042355)3.01409240
58mannosylation (GO:0097502)3.00591837
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00188087
60positive regulation of B cell differentiation (GO:0045579)2.99673010
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98995178
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98995178
63DNA methylation involved in gamete generation (GO:0043046)2.98542505
64positive regulation of defense response to virus by host (GO:0002230)2.97455550
65response to interferon-beta (GO:0035456)2.97295234
66regulation of T cell receptor signaling pathway (GO:0050856)2.95003032
67cellular response to type I interferon (GO:0071357)2.93946579
68type I interferon signaling pathway (GO:0060337)2.93946579
69indolalkylamine metabolic process (GO:0006586)2.93202655
70motile cilium assembly (GO:0044458)2.92660384
71leukocyte aggregation (GO:0070486)2.92625075
72somite development (GO:0061053)2.92436238
73response to type I interferon (GO:0034340)2.92239795
74positive regulation of fatty acid transport (GO:2000193)2.91768886
75purine deoxyribonucleotide catabolic process (GO:0009155)2.90636626
76telomere maintenance via semi-conservative replication (GO:0032201)2.89791769
77purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.88788470
78regulation of germinal center formation (GO:0002634)2.86249114
79positive regulation of glomerulus development (GO:0090193)2.81374617
80mast cell activation (GO:0045576)2.81285789
81positive regulation of DNA recombination (GO:0045911)2.81224002
82negative T cell selection (GO:0043383)2.80137614
83negative thymic T cell selection (GO:0045060)2.79122096
84negative regulation of T-helper cell differentiation (GO:0045623)2.78936956
85negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.78936956
86tryptophan catabolic process (GO:0006569)2.77248190
87indole-containing compound catabolic process (GO:0042436)2.77248190
88indolalkylamine catabolic process (GO:0046218)2.77248190
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77090327
90proteasome assembly (GO:0043248)2.76283664
91telomere maintenance via recombination (GO:0000722)2.76046481
92positive regulation of isotype switching (GO:0045830)2.75634381
93regulation of antigen processing and presentation (GO:0002577)2.74412735
94protein localization to cilium (GO:0061512)2.73426488
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73404217
96signal peptide processing (GO:0006465)2.70425933
97regulation of glomerulus development (GO:0090192)2.68030523
98negative regulation of nitric oxide biosynthetic process (GO:0045019)2.67939387
99cytochrome complex assembly (GO:0017004)2.66033597
100immunoglobulin mediated immune response (GO:0016064)2.65932553
101purine-containing compound salvage (GO:0043101)2.63303789
102regulation of MHC class II biosynthetic process (GO:0045346)2.61890318
103cellular response to interferon-beta (GO:0035458)2.61830321
104secretory granule organization (GO:0033363)2.61504139
105metallo-sulfur cluster assembly (GO:0031163)2.60963693
106iron-sulfur cluster assembly (GO:0016226)2.60963693
107positive regulation of calcium-mediated signaling (GO:0050850)2.59975180
108negative regulation of T cell differentiation in thymus (GO:0033085)2.59967693
109DNA strand elongation (GO:0022616)2.59623180
110negative regulation of telomere maintenance (GO:0032205)2.59005145
111B cell mediated immunity (GO:0019724)2.57781852
112T cell migration (GO:0072678)2.57519634
113GPI anchor biosynthetic process (GO:0006506)2.56242763
114cellular ketone body metabolic process (GO:0046950)2.55834048
115regulation of chronic inflammatory response (GO:0002676)2.55752169
116deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.54560311
117regulation of regulatory T cell differentiation (GO:0045589)2.54531773
118positive regulation of antigen processing and presentation (GO:0002579)2.54352016
119DNA strand elongation involved in DNA replication (GO:0006271)2.53842852
120regulation of activation of Janus kinase activity (GO:0010533)2.53164694
121myeloid dendritic cell activation (GO:0001773)2.52893359
122cellular response to exogenous dsRNA (GO:0071360)2.52459989
123endoderm formation (GO:0001706)2.51764152
124lymphoid progenitor cell differentiation (GO:0002320)2.51709958
125primary amino compound metabolic process (GO:1901160)2.51380128
126mature B cell differentiation involved in immune response (GO:0002313)2.50704102
127kynurenine metabolic process (GO:0070189)2.49579130
128T cell homeostasis (GO:0043029)2.49501115
129negative regulation of mast cell activation (GO:0033004)2.49116931
130cell proliferation in forebrain (GO:0021846)2.49059802
131cellular response to interleukin-15 (GO:0071350)2.46238927
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.46106783
133regulation of T cell mediated cytotoxicity (GO:0001914)2.46050694
134B cell receptor signaling pathway (GO:0050853)2.45998424
135dendritic cell chemotaxis (GO:0002407)2.45071349
136mature B cell differentiation (GO:0002335)2.44046816
137positive regulation of icosanoid secretion (GO:0032305)2.43717801
138negative regulation of viral genome replication (GO:0045071)2.43129722
139endosome to melanosome transport (GO:0035646)2.42304761
140endosome to pigment granule transport (GO:0043485)2.42304761
141regulation of chemokine biosynthetic process (GO:0045073)2.42217835
142Arp2/3 complex-mediated actin nucleation (GO:0034314)2.40903027
143synapsis (GO:0007129)2.39054794
144DNA ligation (GO:0006266)2.38887100
145establishment of protein localization to mitochondrial membrane (GO:0090151)2.38444356
146regulation of natural killer cell differentiation (GO:0032823)2.38277082
147negative regulation of DNA-templated transcription, elongation (GO:0032785)2.38220809
148pharyngeal system development (GO:0060037)2.38083203
149fusion of sperm to egg plasma membrane (GO:0007342)2.37313016
150protein neddylation (GO:0045116)2.37103409
151negative regulation of phagocytosis (GO:0050765)2.36820413
152regulation of type I interferon-mediated signaling pathway (GO:0060338)2.36812600
153negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.36583808
154base-excision repair, AP site formation (GO:0006285)2.36235249
155acrosome reaction (GO:0007340)2.35991008
1563-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.35750219
157purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.35750219
158detection of light stimulus involved in sensory perception (GO:0050962)2.35539102
159detection of light stimulus involved in visual perception (GO:0050908)2.35539102
160membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.35324307
161vitamin biosynthetic process (GO:0009110)2.35031897
162positive regulation of immunoglobulin production (GO:0002639)2.34907134
163tryptophan metabolic process (GO:0006568)2.34625362
164pyrimidine nucleoside catabolic process (GO:0046135)2.34227144
165interferon-gamma-mediated signaling pathway (GO:0060333)2.34133656
166definitive hemopoiesis (GO:0060216)2.33027649
167regulation of alpha-beta T cell proliferation (GO:0046640)2.32623124
168muscle organ morphogenesis (GO:0048644)2.32100593
169negative regulation of T cell differentiation (GO:0045581)2.31514067
170NIK/NF-kappaB signaling (GO:0038061)2.30927720
171regulation of mesoderm development (GO:2000380)2.30841793
172regulation of microtubule-based movement (GO:0060632)2.30756526
173telomere maintenance via telomere lengthening (GO:0010833)2.30598763
174positive regulation of natural killer cell differentiation (GO:0032825)2.29617390
175lymph node development (GO:0048535)2.29517232
176positive regulation of immunoglobulin mediated immune response (GO:0002891)2.28956901
177positive regulation of B cell mediated immunity (GO:0002714)2.28956901
178RNA destabilization (GO:0050779)2.28704182
179regulation of necroptotic process (GO:0060544)2.28525167
180megakaryocyte development (GO:0035855)2.28432592
181regulation of response to interferon-gamma (GO:0060330)2.28406190
182response to interleukin-15 (GO:0070672)2.28177757
183negative regulation of systemic arterial blood pressure (GO:0003085)2.28168360
184indole-containing compound metabolic process (GO:0042430)2.28133398
185RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.27471000
186pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.26346238
187regulation of RIG-I signaling pathway (GO:0039535)2.26334143
188ketone body metabolic process (GO:1902224)2.24125123
189regulation of memory T cell differentiation (GO:0043380)2.23110327
190reproduction (GO:0000003)2.22616202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.98534825
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.91457638
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.87416978
4E2F7_22180533_ChIP-Seq_HELA_Human3.83954276
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65843694
6* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.01160705
7EZH2_22144423_ChIP-Seq_EOC_Human2.97988680
8ZNF274_21170338_ChIP-Seq_K562_Hela2.97944992
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87370619
10* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.83767975
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75730541
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.73014851
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.71314829
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.70047810
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.57890733
16SCL_19346495_ChIP-Seq_HPC-7_Human2.55539017
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48849283
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47729011
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44138358
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41782010
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.41139430
22* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41029052
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.35575515
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32240595
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30835689
26IRF1_19129219_ChIP-ChIP_H3396_Human2.28284754
27NOTCH1_21737748_ChIP-Seq_TLL_Human2.22652670
28VDR_22108803_ChIP-Seq_LS180_Human2.20035412
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19686646
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10802270
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.07047931
32FOXP3_21729870_ChIP-Seq_TREG_Human2.04447314
33SPI1_23547873_ChIP-Seq_NB4_Human2.03948601
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.01940027
35VDR_23849224_ChIP-Seq_CD4+_Human1.98862219
36* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98269826
37ERG_20887958_ChIP-Seq_HPC-7_Mouse1.96238017
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94425474
39MYB_26560356_Chip-Seq_TH2_Human1.93241581
40* SRF_21415370_ChIP-Seq_HL-1_Mouse1.92751160
41GATA1_22025678_ChIP-Seq_K562_Human1.89535681
42* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.88865172
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.87916199
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81325163
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80374346
46* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78562959
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76962684
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75601595
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69174099
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66469872
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.65936627
52GBX2_23144817_ChIP-Seq_PC3_Human1.65915273
53VDR_21846776_ChIP-Seq_THP-1_Human1.65717587
54MYB_26560356_Chip-Seq_TH1_Human1.65279757
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63696041
56CIITA_25753668_ChIP-Seq_RAJI_Human1.63641446
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63371529
58* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61951423
59MYC_22102868_ChIP-Seq_BL_Human1.60854555
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60133850
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.59124054
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58628099
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58352223
64ER_23166858_ChIP-Seq_MCF-7_Human1.57741527
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.57409656
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55372275
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54854993
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52603177
69MAF_26560356_Chip-Seq_TH1_Human1.52135115
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.52007187
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51348637
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.50900715
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50900715
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48986642
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48531906
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48335816
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47929835
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47544487
79RUNX_20019798_ChIP-Seq_JUKART_Human1.46466349
80NANOG_20526341_ChIP-Seq_ESCs_Human1.45956862
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45523230
82NCOR_22424771_ChIP-Seq_293T_Human1.44536100
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.43776706
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43327739
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43320757
86VDR_24763502_ChIP-Seq_THP-1_Human1.42926101
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42114273
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40080214
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40078120
90* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38956343
91TAF2_19829295_ChIP-Seq_ESCs_Human1.38851227
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38785335
93MYC_18940864_ChIP-ChIP_HL60_Human1.38720225
94* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37363758
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.37272530
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35722740
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.35245211
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34406652
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33899004
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33441815
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33318092
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32414537
103CBP_20019798_ChIP-Seq_JUKART_Human1.32414537
104* GABP_19822575_ChIP-Seq_HepG2_Human1.31948617
105BCL6_27268052_Chip-Seq_Bcells_Human1.31361550
106ERA_21632823_ChIP-Seq_H3396_Human1.31268022
107TP53_22573176_ChIP-Seq_HFKS_Human1.31091687
108TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.27369178
109FUS_26573619_Chip-Seq_HEK293_Human1.27047255
110RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.26965615
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26506375
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.25848518
113MYC_19829295_ChIP-Seq_ESCs_Human1.25820666
114UTX_26944678_Chip-Seq_JUKART_Human1.24690185
115NANOG_19829295_ChIP-Seq_ESCs_Human1.24348014
116SOX2_19829295_ChIP-Seq_ESCs_Human1.24348014
117MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23233227
118DCP1A_22483619_ChIP-Seq_HELA_Human1.22061806
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20807194
120ELK1_19687146_ChIP-ChIP_HELA_Human1.20333165
121E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19886126
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17764891
123AR_20517297_ChIP-Seq_VCAP_Human1.17536130
124YY1_21170310_ChIP-Seq_MESCs_Mouse1.17432484
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17176605
126TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16110266
127P300_19829295_ChIP-Seq_ESCs_Human1.14904095
128ERG_20517297_ChIP-Seq_VCAP_Human1.14368719
129FLI1_27457419_Chip-Seq_LIVER_Mouse1.14334604
130BCAT_22108803_ChIP-Seq_LS180_Human1.13948892
131EWS_26573619_Chip-Seq_HEK293_Human1.12317815
132NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10656588
133IGF1R_20145208_ChIP-Seq_DFB_Human1.10645954
134CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10209045
135MAF_26560356_Chip-Seq_TH2_Human1.09956325
136YY1_22570637_ChIP-Seq_MALME-3M_Human1.09908787
137VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09812812
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09578277
139RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08221361
140HOXB7_26014856_ChIP-Seq_BT474_Human1.08178107
141BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07916323
142TAF15_26573619_Chip-Seq_HEK293_Human1.07840097
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07119378
144P300_27268052_Chip-Seq_Bcells_Human1.07059838
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06976152
146PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06417255
147SMRT_27268052_Chip-Seq_Bcells_Human1.05431000
148CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05404313
149XRN2_22483619_ChIP-Seq_HELA_Human1.05059036
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04867235
151FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04767830
152STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04566174
153CBX2_27304074_Chip-Seq_ESCs_Mouse1.03587850
154OCT4_20526341_ChIP-Seq_ESCs_Human1.03274741
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02074906
156THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01952603
157NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01220642
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00700505
159CTCF_20526341_ChIP-Seq_ESCs_Human1.00603891
160GATA3_26560356_Chip-Seq_TH2_Human1.00562629
161SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99698155
162MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99676367
163* RAC3_21632823_ChIP-Seq_H3396_Human0.99648322
164TTF2_22483619_ChIP-Seq_HELA_Human0.99587212
165STAT1_20625510_ChIP-Seq_HELA_Human0.99497385
166FOXH1_21741376_ChIP-Seq_EPCs_Human0.99401985
167P53_21459846_ChIP-Seq_SAOS-2_Human0.98455009
168GATA3_27048872_Chip-Seq_THYMUS_Human0.98062894
169CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97898644
170POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96699669
171RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96573574
172PRDM14_20953172_ChIP-Seq_ESCs_Human0.96430037
173PU_27001747_Chip-Seq_BMDM_Mouse0.96149712
174GATA1_19941827_ChIP-Seq_MEL_Mouse0.95624875
175FOXH1_21741376_ChIP-Seq_ESCs_Human0.92785636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.89461800
2MP0001835_abnormal_antigen_presentation4.12126239
3MP0002837_dystrophic_cardiac_calcinosis3.98884799
4MP0005671_abnormal_response_to3.34001643
5MP0009785_altered_susceptibility_to3.20242700
6MP0000685_abnormal_immune_system3.19106973
7MP0002396_abnormal_hematopoietic_system2.92425269
8MP0003763_abnormal_thymus_physiology2.80864600
9MP0001800_abnormal_humoral_immune2.63122031
10MP0001873_stomach_inflammation2.55765353
11MP0005387_immune_system_phenotype2.48259984
12MP0001790_abnormal_immune_system2.48259984
13MP0005025_abnormal_response_to2.47880577
14MP0005646_abnormal_pituitary_gland2.44856964
15MP0002148_abnormal_hypersensitivity_rea2.42899564
16MP0002723_abnormal_immune_serum2.37831566
17MP0005000_abnormal_immune_tolerance2.34406033
18MP0002452_abnormal_antigen_presenting2.30392406
19MP0002420_abnormal_adaptive_immunity2.27242389
20MP0005310_abnormal_salivary_gland2.27178369
21MP0001485_abnormal_pinna_reflex2.26844018
22MP0001819_abnormal_immune_cell2.25041105
23MP0005670_abnormal_white_adipose2.24300233
24MP0002398_abnormal_bone_marrow2.21171938
25MP0003436_decreased_susceptibility_to2.17530976
26MP0002653_abnormal_ependyma_morphology2.06192424
27MP0002419_abnormal_innate_immunity2.05150833
28MP0003724_increased_susceptibility_to2.04909538
29MP0008058_abnormal_DNA_repair2.02634385
30MP0002876_abnormal_thyroid_physiology1.99599463
31MP0000716_abnormal_immune_system1.97277854
32MP0009333_abnormal_splenocyte_physiolog1.92494464
33MP0005464_abnormal_platelet_physiology1.90788675
34MP0000689_abnormal_spleen_morphology1.89462812
35MP0006082_CNS_inflammation1.88667506
36MP0001968_abnormal_touch/_nociception1.86982005
37MP0002405_respiratory_system_inflammati1.83104505
38MP0001853_heart_inflammation1.79035451
39MP0002722_abnormal_immune_system1.77580780
40MP0002429_abnormal_blood_cell1.74056404
41MP0005075_abnormal_melanosome_morpholog1.74034850
42MP0002166_altered_tumor_susceptibility1.73876161
43MP0005174_abnormal_tail_pigmentation1.72141487
44MP0002132_abnormal_respiratory_system1.71732292
45MP0001348_abnormal_lacrimal_gland1.71110662
46MP0010155_abnormal_intestine_physiology1.68258225
47MP0006292_abnormal_olfactory_placode1.66268813
48MP0003011_delayed_dark_adaptation1.66093276
49MP0008872_abnormal_physiological_respon1.64419187
50MP0004147_increased_porphyrin_level1.61962313
51MP0004130_abnormal_muscle_cell1.61019648
52MP0000465_gastrointestinal_hemorrhage1.58895243
53MP0010094_abnormal_chromosome_stability1.57461612
54MP0000490_abnormal_crypts_of1.55551411
55MP0003195_calcinosis1.55305436
56MP0001845_abnormal_inflammatory_respons1.53571971
57MP0003693_abnormal_embryo_hatching1.52730946
58MP0004808_abnormal_hematopoietic_stem1.50613080
59MP0000703_abnormal_thymus_morphology1.50353126
60MP0002736_abnormal_nociception_after1.49438179
61MP0008007_abnormal_cellular_replicative1.46115674
62MP0002006_tumorigenesis1.45245680
63MP0002102_abnormal_ear_morphology1.45060340
64MP0002160_abnormal_reproductive_system1.43920699
65MP0005389_reproductive_system_phenotype1.41315691
66MP0008469_abnormal_protein_level1.40349009
67MP0004885_abnormal_endolymph1.39998836
68MP0008875_abnormal_xenobiotic_pharmacok1.39058226
69MP0001986_abnormal_taste_sensitivity1.37870098
70MP0005551_abnormal_eye_electrophysiolog1.33297731
71MP0003866_abnormal_defecation1.32879368
72MP0005397_hematopoietic_system_phenotyp1.32565189
73MP0001545_abnormal_hematopoietic_system1.32565189
74MP0009697_abnormal_copulation1.31363698
75MP0000678_abnormal_parathyroid_gland1.30097611
76MP0003186_abnormal_redox_activity1.25754638
77MP0001905_abnormal_dopamine_level1.22735040
78MP0008789_abnormal_olfactory_epithelium1.19702898
79MP0004510_myositis1.18838600
80MP0004742_abnormal_vestibular_system1.15790395
81MP0006072_abnormal_retinal_apoptosis1.15750413
82MP0000372_irregular_coat_pigmentation1.15348486
83MP0004947_skin_inflammation1.14820092
84MP0003878_abnormal_ear_physiology1.11972432
85MP0005377_hearing/vestibular/ear_phenot1.11972432
86MP0002138_abnormal_hepatobiliary_system1.11589053
87MP0005367_renal/urinary_system_phenotyp1.11407589
88MP0000516_abnormal_urinary_system1.11407589
89MP0002095_abnormal_skin_pigmentation1.10571800
90MP0002933_joint_inflammation1.09164948
91MP0004133_heterotaxia1.08529258
92MP0000015_abnormal_ear_pigmentation1.07540173
93MP0003786_premature_aging1.07523664
94MP0008260_abnormal_autophagy1.06687535
95MP0003077_abnormal_cell_cycle1.06539771
96MP0000049_abnormal_middle_ear1.06194464
97MP0002019_abnormal_tumor_incidence1.05409595
98MP0000631_abnormal_neuroendocrine_gland1.05254126
99MP0003943_abnormal_hepatobiliary_system1.03479998
100MP0001919_abnormal_reproductive_system1.03181641
101MP0005058_abnormal_lysosome_morphology1.03164904
102MP0009745_abnormal_behavioral_response1.02682842
103MP0001764_abnormal_homeostasis1.01666380
104MP0008775_abnormal_heart_ventricle1.01378964
105MP0003698_abnormal_male_reproductive1.00404104
106MP0001963_abnormal_hearing_physiology1.00396202
107MP0002009_preneoplasia0.99831975
108MP0004142_abnormal_muscle_tone0.98961936
109MP0005253_abnormal_eye_physiology0.98613113
110MP0003111_abnormal_nucleus_morphology0.98301549
111MP0005410_abnormal_fertilization0.97496047
112MP0004185_abnormal_adipocyte_glucose0.97368188
113MP0003656_abnormal_erythrocyte_physiolo0.95428152
114MP0003938_abnormal_ear_development0.95226793
115MP0002282_abnormal_trachea_morphology0.94518083
116MP0005360_urolithiasis0.94147641
117MP0002735_abnormal_chemical_nociception0.93807729
118MP0008057_abnormal_DNA_replication0.93314341
119MP0000858_altered_metastatic_potential0.92920897
120MP0004145_abnormal_muscle_electrophysio0.90364366
121MP0002272_abnormal_nervous_system0.90105050
122MP0003172_abnormal_lysosome_physiology0.89572952
123MP0005084_abnormal_gallbladder_morpholo0.88601055
124MP0006036_abnormal_mitochondrial_physio0.88507956
125MP0001765_abnormal_ion_homeostasis0.87995375
126MP0002277_abnormal_respiratory_mucosa0.87160919
127MP0009764_decreased_sensitivity_to0.86913375
128MP0000371_diluted_coat_color0.86200696
129MP0003879_abnormal_hair_cell0.85975033
130MP0002733_abnormal_thermal_nociception0.85672468
131MP0001486_abnormal_startle_reflex0.85281369
132MP0005645_abnormal_hypothalamus_physiol0.84094561
133MP0000313_abnormal_cell_death0.83874341
134MP0001529_abnormal_vocalization0.83626908
135MP0004957_abnormal_blastocyst_morpholog0.83510729
136MP0002693_abnormal_pancreas_physiology0.82006906
137MP0002638_abnormal_pupillary_reflex0.81798759
138MP0001501_abnormal_sleep_pattern0.81260940
139MP0000026_abnormal_inner_ear0.80125782
140MP0009053_abnormal_anal_canal0.78977331
141MP0009763_increased_sensitivity_to0.78082224
142MP0008877_abnormal_DNA_methylation0.77228824
143MP0000230_abnormal_systemic_arterial0.77161453
144MP0009765_abnormal_xenobiotic_induced0.76621575
145MP0001533_abnormal_skeleton_physiology0.76501304
146MP0000569_abnormal_digit_pigmentation0.76301109
147MP0003806_abnormal_nucleotide_metabolis0.75132754
148MP0009046_muscle_twitch0.75001186
149MP0005365_abnormal_bile_salt0.71254117
150MP0003191_abnormal_cellular_cholesterol0.70069543
151MP0001663_abnormal_digestive_system0.69014922
152MP0002928_abnormal_bile_duct0.67558698
153MP0003183_abnormal_peptide_metabolism0.67436222
154MP0008995_early_reproductive_senescence0.65559184
155MP0001929_abnormal_gametogenesis0.64776401
156MP0009379_abnormal_foot_pigmentation0.63821759
157MP0002136_abnormal_kidney_physiology0.62432071
158MP0004782_abnormal_surfactant_physiolog0.62026759
159MP0002139_abnormal_hepatobiliary_system0.61770605
160MP0009643_abnormal_urine_homeostasis0.61596236

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)4.30168670
2IgM deficiency (HP:0002850)4.20917731
3Myositis (HP:0100614)4.18981843
4Elevated erythrocyte sedimentation rate (HP:0003565)4.08996444
5Chronic otitis media (HP:0000389)3.76844843
6Abnormality of the nasal mucosa (HP:0000433)3.72196077
7Recurrent bronchitis (HP:0002837)3.70738541
8Pancreatic cysts (HP:0001737)3.62991034
9Recurrent abscess formation (HP:0002722)3.55113106
10Nephronophthisis (HP:0000090)3.54295256
11Absent/shortened dynein arms (HP:0200106)3.54275180
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.54275180
13Optic neuritis (HP:0100653)3.46280306
14Retrobulbar optic neuritis (HP:0100654)3.46280306
15True hermaphroditism (HP:0010459)3.44330546
16Pancreatic fibrosis (HP:0100732)3.39591346
17Aplastic anemia (HP:0001915)3.33385890
18Molar tooth sign on MRI (HP:0002419)3.26280723
19Abnormality of midbrain morphology (HP:0002418)3.26280723
20Thrombocytosis (HP:0001894)3.23267729
21Orchitis (HP:0100796)3.17579872
22Short 1st metacarpal (HP:0010034)3.12795713
23Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.12795713
24Recurrent bacterial skin infections (HP:0005406)3.10609916
25Autoimmune thrombocytopenia (HP:0001973)3.02229335
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.99926488
27Recurrent fungal infections (HP:0002841)2.99773542
28Reduced antithrombin III activity (HP:0001976)2.97302548
29Agammaglobulinemia (HP:0004432)2.94415783
30Recurrent viral infections (HP:0004429)2.94227245
31Type I transferrin isoform profile (HP:0003642)2.93406896
32Congenital stationary night blindness (HP:0007642)2.92204871
33Meningitis (HP:0001287)2.89729119
34Abnormality of the renal medulla (HP:0100957)2.89378773
35IgG deficiency (HP:0004315)2.88549658
36Abnormality of B cell number (HP:0010975)2.88398116
37B lymphocytopenia (HP:0010976)2.88398116
38Abnormal rod and cone electroretinograms (HP:0008323)2.82230597
39Abnormality of T cell physiology (HP:0011840)2.80193092
40Petechiae (HP:0000967)2.79705459
41Methylmalonic acidemia (HP:0002912)2.78222014
42Abnormality of T cells (HP:0002843)2.77327963
43Abnormal respiratory motile cilium physiology (HP:0012261)2.77303237
44Abnormality of the 1st metacarpal (HP:0010009)2.77081764
45Severe visual impairment (HP:0001141)2.74481837
46Methylmalonic aciduria (HP:0012120)2.73673922
47Panhypogammaglobulinemia (HP:0003139)2.72430223
48Abolished electroretinogram (ERG) (HP:0000550)2.71839970
49Abnormality of T cell number (HP:0011839)2.70886418
50Attenuation of retinal blood vessels (HP:0007843)2.67801112
51Recurrent skin infections (HP:0001581)2.64475126
52Abnormality of the proximal phalanges of the hand (HP:0009834)2.61751324
53Recurrent sinusitis (HP:0011108)2.60991280
54Pendular nystagmus (HP:0012043)2.60347249
55Bronchitis (HP:0012387)2.60012247
56Pancytopenia (HP:0001876)2.58184080
57Lymphopenia (HP:0001888)2.57704003
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.57439471
59Chronic sinusitis (HP:0011109)2.56366770
60Eczematoid dermatitis (HP:0000976)2.56139691
61Severe combined immunodeficiency (HP:0004430)2.54871564
62Encephalitis (HP:0002383)2.54399075
63T lymphocytopenia (HP:0005403)2.53788443
64Recurrent cutaneous fungal infections (HP:0011370)2.50915824
65Chronic mucocutaneous candidiasis (HP:0002728)2.50915824
66Vasculitis (HP:0002633)2.50376993
67Abnormal respiratory motile cilium morphology (HP:0005938)2.49723096
68Abnormal respiratory epithelium morphology (HP:0012253)2.49723096
69Hyperglycinemia (HP:0002154)2.48664496
70Congenital sensorineural hearing impairment (HP:0008527)2.47337528
71Abnormal protein N-linked glycosylation (HP:0012347)2.42882200
72Abnormal protein glycosylation (HP:0012346)2.42882200
73Abnormal glycosylation (HP:0012345)2.42882200
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42882200
75Keratoconjunctivitis sicca (HP:0001097)2.39866350
76Reticulocytopenia (HP:0001896)2.37070487
77Asplenia (HP:0001746)2.35938582
78Abnormality of the renal cortex (HP:0011035)2.35141291
79Aplasia/Hypoplasia of the spleen (HP:0010451)2.35049892
80Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34389891
81Mediastinal lymphadenopathy (HP:0100721)2.32915591
82Acute necrotizing encephalopathy (HP:0006965)2.32665122
83Chronic diarrhea (HP:0002028)2.32315977
84Cystic liver disease (HP:0006706)2.30461574
85Inflammation of the large intestine (HP:0002037)2.29845250
863-Methylglutaconic aciduria (HP:0003535)2.29529329
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29426079
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29426079
89Abnormality of the heme biosynthetic pathway (HP:0010472)2.29114960
90Combined immunodeficiency (HP:0005387)2.28584973
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.28265761
92Mitochondrial inheritance (HP:0001427)2.27781891
93Abnormality of the renal collecting system (HP:0004742)2.26480485
94Carpal bone hypoplasia (HP:0001498)2.26387970
95Chronic hepatic failure (HP:0100626)2.26076392
96Bony spicule pigmentary retinopathy (HP:0007737)2.25390338
97Thyroiditis (HP:0100646)2.24011726
98Abnormal number of erythroid precursors (HP:0012131)2.23887424
99Cutaneous melanoma (HP:0012056)2.23485230
100Gastrointestinal inflammation (HP:0004386)2.23368688
101Chromsome breakage (HP:0040012)2.22796505
102Hypoplasia of the thymus (HP:0000778)2.22603064
103Abnormality of the fingertips (HP:0001211)2.19523928
104Autoimmune hemolytic anemia (HP:0001890)2.18725807
105Keratoconjunctivitis (HP:0001096)2.18701479
106Progressive macrocephaly (HP:0004481)2.17164945
107Decreased central vision (HP:0007663)2.17102665
108Abnormality of macrophages (HP:0004311)2.17076333
109Prolonged bleeding time (HP:0003010)2.16826634
110Type 2 muscle fiber atrophy (HP:0003554)2.16747509
111Bronchiectasis (HP:0002110)2.16657890
112Eosinophilia (HP:0001880)2.16510580
113Neutropenia (HP:0001875)2.16255976
114Abnormality of eosinophils (HP:0001879)2.15435648
115Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12969654
116Stomatitis (HP:0010280)2.12286085
117Lymphoma (HP:0002665)2.12266789
118Cellulitis (HP:0100658)2.12252809
119Abnormality of the prostate (HP:0008775)2.11286578
120Medial flaring of the eyebrow (HP:0010747)2.10894250
121Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.09697650
122Abnormal mitochondria in muscle tissue (HP:0008316)2.09218899
123Hypoplasia of the uterus (HP:0000013)2.09111311
124Stenosis of the external auditory canal (HP:0000402)2.09035704
125Leukocytosis (HP:0001974)2.08510936
126Short phalanx of the thumb (HP:0009660)2.05306147
127Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04707538
128Abnormality of cells of the erythroid lineage (HP:0012130)2.04175366
129Increased CSF lactate (HP:0002490)2.04117692
130Recurrent gram-negative bacterial infections (HP:0005420)2.04021643
131Albinism (HP:0001022)2.03090463
132Absent thumb (HP:0009777)2.02947422
133Myelodysplasia (HP:0002863)2.02450773
134Gastrointestinal stroma tumor (HP:0100723)2.02400714
135Decreased circulating renin level (HP:0003351)2.01674048
136Abnormal ciliary motility (HP:0012262)2.01551383
137Granulocytopenia (HP:0001913)2.01457460
138Acute encephalopathy (HP:0006846)2.01404181
139Genetic anticipation (HP:0003743)1.99215690
140Acute myeloid leukemia (HP:0004808)1.98854302
141Short hallux (HP:0010109)1.98255546
142Abnormality of the nasal septum (HP:0000419)1.97234992
143Abnormality of DNA repair (HP:0003254)1.96831981
144Clubbing of toes (HP:0100760)1.95526645
145Sclerocornea (HP:0000647)1.94056264
146Furrowed tongue (HP:0000221)1.93582594
147Epistaxis (HP:0000421)1.93410169
148Abnormality of the phalanges of the 5th finger (HP:0004213)1.92840611
149Renal cortical cysts (HP:0000803)1.92757938
150Bone marrow hypocellularity (HP:0005528)1.92077456
151Aplasia/Hypoplasia of the hallux (HP:0008362)1.92059948
152Progressive cerebellar ataxia (HP:0002073)1.91930543
153Congenital hepatic fibrosis (HP:0002612)1.91399004
154Pulmonary infiltrates (HP:0002113)1.90974625
155Increased IgM level (HP:0003496)1.89961149
156Aplasia/hypoplasia of the uterus (HP:0008684)1.89812605
157Recurrent pneumonia (HP:0006532)1.89401891
158Colitis (HP:0002583)1.87519449
159Abnormality of the middle phalanges of the toes (HP:0010183)1.86225319
160Hepatocellular necrosis (HP:0001404)1.85420970
161Hemoptysis (HP:0002105)1.85145661
162Rhinitis (HP:0012384)1.84053938
163Congenital, generalized hypertrichosis (HP:0004540)1.83931792
164Male pseudohermaphroditism (HP:0000037)1.83907100
165Muscle fiber atrophy (HP:0100295)1.83698700
166Ragged-red muscle fibers (HP:0003200)1.81931100
167Abnormality of the costochondral junction (HP:0000919)1.78315893
168Aplasia/Hypoplasia of the tibia (HP:0005772)1.74384382
169Type II lissencephaly (HP:0007260)1.72997468
170Ketosis (HP:0001946)1.72934460
171Bile duct proliferation (HP:0001408)1.72870971
172Abnormal biliary tract physiology (HP:0012439)1.72870971
173Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72497587
174Dicarboxylic aciduria (HP:0003215)1.72497587
175Postaxial foot polydactyly (HP:0001830)1.71289434
176Tubular atrophy (HP:0000092)1.71024536
177Abnormality of vitamin B metabolism (HP:0004340)1.70859281
178Optic disc pallor (HP:0000543)1.70766418
179Anencephaly (HP:0002323)1.70261591
180Symphalangism affecting the phalanges of the hand (HP:0009773)1.69551662
181Chorioretinal atrophy (HP:0000533)1.69029144
182Abnormality of the vitamin B12 metabolism (HP:0004341)1.67003049
183Morphological abnormality of the middle ear (HP:0008609)1.66194179
184Abnormal albumin level (HP:0012116)1.65343876
185Hypoalbuminemia (HP:0003073)1.65343876
186Cerebral palsy (HP:0100021)1.65322818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.47446517
2MAP4K13.70516532
3TLK13.26327797
4STK163.24084689
5TXK3.09111384
6MAP4K22.53518341
7KIT2.37189392
8TEC2.35424529
9IKBKE2.31681995
10NUAK12.27705052
11IRAK42.27473287
12FLT32.26564212
13RIPK42.14660908
14ZAP702.13228961
15BTK2.11560386
16ACVR1B2.05531084
17JAK32.05259354
18TBK12.04402481
19MAP3K121.90131167
20INSRR1.81109278
21PINK11.76793515
22TGFBR21.74923672
23BUB11.73614940
24MAP3K141.73580803
25TYK21.69417066
26KDR1.62496315
27PASK1.60536863
28CSF1R1.56332146
29BLK1.53866173
30IKBKB1.53664828
31WNK41.52292027
32SYK1.48648564
33CHUK1.42606149
34MUSK1.40807798
35EIF2AK31.39776892
36IRAK31.36732926
37SRPK11.34398293
38NME21.32171111
39TGFBR11.30011934
40MAPK131.28609149
41EIF2AK11.27846403
42NLK1.24518444
43MYLK1.24133973
44VRK11.19646780
45TNIK1.19373725
46OXSR11.19096759
47ITK1.19048837
48WNK31.17372867
49CLK11.16915966
50DYRK21.13994290
51PIM21.13363169
52BMPR1B1.12839499
53LCK1.12382639
54DYRK31.09921812
55MAP3K91.09065963
56PIM11.08727579
57LYN1.08660826
58ZAK1.07238286
59STK101.02860164
60TESK21.01156310
61SIK20.99619166
62STK390.98131881
63GRK60.98004021
64CSNK1G30.96253368
65RPS6KA40.93264733
66MAP3K130.93109030
67EIF2AK20.91058070
68SIK30.91013757
69MKNK20.90715419
70ADRBK20.90377793
71VRK20.89403241
72MAP2K60.88978425
73CDK190.88766752
74GRK70.88305453
75STK40.88128598
76TAOK30.87870089
77TNK20.87510713
78ATR0.83767673
79ADRBK10.83487618
80FGFR40.81808706
81MAP2K30.81277500
82CSNK1G20.79588929
83TESK10.78279949
84CDK90.77420893
85PLK20.77202320
86FGFR20.77165784
87PLK40.76528601
88MKNK10.75587402
89MAP2K20.74971463
90JAK10.74534857
91GRK10.72914678
92NEK20.71964764
93CSNK1G10.71329297
94MST40.70280676
95PTK2B0.67647733
96NEK90.64293833
97WEE10.61191480
98MAP2K70.61157318
99NME10.60887620
100YES10.60850413
101CDK70.60207541
102RPS6KA50.60024029
103CSNK1A1L0.59486080
104TIE10.59405307
105CDC70.59028097
106MAPKAPK30.58553018
107DAPK20.58513404
108PAK40.58248667
109HCK0.58006965
110BRSK20.56895049
111PIK3CA0.55679334
112FES0.55552682
113MAP2K10.55134010
114MAP3K100.54039040
115PRKD20.53795862
116BCKDK0.53528759
117CSK0.53522817
118MAPK110.53485488
119MAP3K40.53381293
120AURKB0.52590926
121PIK3CG0.52089381
122PHKG20.48670630
123PHKG10.48670630
124PRKCE0.48234469
125IRAK10.48020895
126PRKACA0.47797697
127MAP3K110.46780627
128GRK50.45995874
129PAK30.45586473
130EPHB10.45125193
131MAPKAPK20.44163990
132CAMKK20.44162828
133CDK40.43702622
134MATK0.43161821
135MAP3K70.42705947
136PRKCZ0.42664632
137CSNK1A10.42398077
138HIPK20.40833852
139PRKCQ0.39965584
140PRKG20.39955799
141RPS6KB20.39644379
142NTRK30.38529073
143PRKCD0.38076705
144PRKCI0.37477195
145PRKCG0.37382351
146PKN10.37277618
147PRKCA0.36503447
148RPS6KA60.35938091
149PDK10.35852694
150AURKA0.35824760
151MAPK150.35800059
152CCNB10.35777620
153STK380.35318247
154SGK10.34184768

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.29706163
2DNA replication_Homo sapiens_hsa030303.17118057
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.57035104
4Base excision repair_Homo sapiens_hsa034102.56700695
5Allograft rejection_Homo sapiens_hsa053302.53974867
6Mismatch repair_Homo sapiens_hsa034302.44288418
7Homologous recombination_Homo sapiens_hsa034402.41185887
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.37068324
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29809563
10Oxidative phosphorylation_Homo sapiens_hsa001902.26692619
11Ribosome_Homo sapiens_hsa030102.26469500
12Non-homologous end-joining_Homo sapiens_hsa034502.10867417
13Phototransduction_Homo sapiens_hsa047442.09282641
14Sulfur metabolism_Homo sapiens_hsa009202.02582635
15Measles_Homo sapiens_hsa051621.95993414
16Proteasome_Homo sapiens_hsa030501.94290983
17Linoleic acid metabolism_Homo sapiens_hsa005911.90050723
18Antigen processing and presentation_Homo sapiens_hsa046121.78778878
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.72509293
20Nitrogen metabolism_Homo sapiens_hsa009101.71952106
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71695962
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69685893
23Leishmaniasis_Homo sapiens_hsa051401.69626798
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64848473
25Protein export_Homo sapiens_hsa030601.64469733
26Pyrimidine metabolism_Homo sapiens_hsa002401.63695206
27Herpes simplex infection_Homo sapiens_hsa051681.62970652
28Nucleotide excision repair_Homo sapiens_hsa034201.62948891
29Spliceosome_Homo sapiens_hsa030401.62695661
30RNA polymerase_Homo sapiens_hsa030201.62205668
31Parkinsons disease_Homo sapiens_hsa050121.62133650
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55925664
33Fanconi anemia pathway_Homo sapiens_hsa034601.51925604
34Chemical carcinogenesis_Homo sapiens_hsa052041.50833497
35Hematopoietic cell lineage_Homo sapiens_hsa046401.49834002
36Asthma_Homo sapiens_hsa053101.46632494
37Caffeine metabolism_Homo sapiens_hsa002321.44113533
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41970149
39Graft-versus-host disease_Homo sapiens_hsa053321.41333971
40Autoimmune thyroid disease_Homo sapiens_hsa053201.33644466
41Folate biosynthesis_Homo sapiens_hsa007901.25585802
42Retinol metabolism_Homo sapiens_hsa008301.24288670
43Basal transcription factors_Homo sapiens_hsa030221.23774069
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23631184
45B cell receptor signaling pathway_Homo sapiens_hsa046621.23553611
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23262575
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22943768
48Olfactory transduction_Homo sapiens_hsa047401.22846421
49Collecting duct acid secretion_Homo sapiens_hsa049661.21316580
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21116047
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19222005
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17161112
53Rheumatoid arthritis_Homo sapiens_hsa053231.16701059
54Nicotine addiction_Homo sapiens_hsa050331.16614267
55Legionellosis_Homo sapiens_hsa051341.14984390
56Butanoate metabolism_Homo sapiens_hsa006501.14663621
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.14523966
58Huntingtons disease_Homo sapiens_hsa050161.14276642
59Glycerolipid metabolism_Homo sapiens_hsa005611.12344819
60RNA degradation_Homo sapiens_hsa030181.11569921
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09888035
62Alzheimers disease_Homo sapiens_hsa050101.09497745
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.07955115
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06809737
65Selenocompound metabolism_Homo sapiens_hsa004501.06632155
66Tryptophan metabolism_Homo sapiens_hsa003801.06306883
67Other glycan degradation_Homo sapiens_hsa005111.03788126
68Purine metabolism_Homo sapiens_hsa002301.01818951
69Arachidonic acid metabolism_Homo sapiens_hsa005901.01445621
70Pentose phosphate pathway_Homo sapiens_hsa000301.00863137
71T cell receptor signaling pathway_Homo sapiens_hsa046600.99789681
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99543722
73Influenza A_Homo sapiens_hsa051640.99307702
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.97036053
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96281568
76Ether lipid metabolism_Homo sapiens_hsa005650.95495331
77One carbon pool by folate_Homo sapiens_hsa006700.94881337
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93499529
79Cell cycle_Homo sapiens_hsa041100.93424589
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90065020
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.89977329
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88868459
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87508449
84Osteoclast differentiation_Homo sapiens_hsa043800.87391631
85Fat digestion and absorption_Homo sapiens_hsa049750.86746220
86Type II diabetes mellitus_Homo sapiens_hsa049300.85671557
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83922167
88Staphylococcus aureus infection_Homo sapiens_hsa051500.81794940
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81619076
90ABC transporters_Homo sapiens_hsa020100.81063897
91Morphine addiction_Homo sapiens_hsa050320.80584542
92p53 signaling pathway_Homo sapiens_hsa041150.80527904
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.80001465
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78880640
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75179251
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74789535
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73610572
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72657447
99Epstein-Barr virus infection_Homo sapiens_hsa051690.71924679
100Shigellosis_Homo sapiens_hsa051310.70537307
101Fatty acid elongation_Homo sapiens_hsa000620.69158241
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.68777057
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68278809
104Taste transduction_Homo sapiens_hsa047420.66863063
105N-Glycan biosynthesis_Homo sapiens_hsa005100.64535121
106Malaria_Homo sapiens_hsa051440.64195842
107Pertussis_Homo sapiens_hsa051330.63847141
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63761713
109Cardiac muscle contraction_Homo sapiens_hsa042600.60632819
110Peroxisome_Homo sapiens_hsa041460.60403725
111Regulation of autophagy_Homo sapiens_hsa041400.58576782
112Apoptosis_Homo sapiens_hsa042100.55783975
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.54270972
114Glutathione metabolism_Homo sapiens_hsa004800.53962416
115RNA transport_Homo sapiens_hsa030130.53899389
116Dorso-ventral axis formation_Homo sapiens_hsa043200.53051375
117Serotonergic synapse_Homo sapiens_hsa047260.52616700
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50171929
119Hepatitis B_Homo sapiens_hsa051610.49674797
120Sulfur relay system_Homo sapiens_hsa041220.49408004
121Fatty acid biosynthesis_Homo sapiens_hsa000610.49223300
122Acute myeloid leukemia_Homo sapiens_hsa052210.48188803
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47444246
124Toxoplasmosis_Homo sapiens_hsa051450.47303608
125Type I diabetes mellitus_Homo sapiens_hsa049400.47154481
126Systemic lupus erythematosus_Homo sapiens_hsa053220.45690735
127Vitamin digestion and absorption_Homo sapiens_hsa049770.43831524
128Tuberculosis_Homo sapiens_hsa051520.43644697
129Histidine metabolism_Homo sapiens_hsa003400.42786155
130HTLV-I infection_Homo sapiens_hsa051660.40622941
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.39767675
132Renin-angiotensin system_Homo sapiens_hsa046140.38915043
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38850819
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38726306
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.38603429
136TNF signaling pathway_Homo sapiens_hsa046680.38359499
137Sphingolipid metabolism_Homo sapiens_hsa006000.38344927
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37974049
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36889454
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.36589710
141Propanoate metabolism_Homo sapiens_hsa006400.36317065
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34908731
143Pyruvate metabolism_Homo sapiens_hsa006200.34634533
144Circadian entrainment_Homo sapiens_hsa047130.34497976
145Notch signaling pathway_Homo sapiens_hsa043300.34398790
146Metabolic pathways_Homo sapiens_hsa011000.33696112
147Calcium signaling pathway_Homo sapiens_hsa040200.31752805
148Fatty acid degradation_Homo sapiens_hsa000710.31330719

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