VSIG10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of keratinocyte proliferation (GO:0010839)5.43003494
2DNA double-strand break processing (GO:0000729)4.73130533
3negative regulation of DNA-dependent DNA replication (GO:2000104)4.64292200
4DNA replication checkpoint (GO:0000076)4.43453528
5interferon-gamma secretion (GO:0072643)4.06457372
6chromatin remodeling at centromere (GO:0031055)4.03134215
7anterior/posterior axis specification, embryo (GO:0008595)4.00563253
8regulation of nuclear cell cycle DNA replication (GO:0033262)3.89599312
9regulation of male gonad development (GO:2000018)3.83853305
10bundle of His cell to Purkinje myocyte communication (GO:0086069)3.73562064
11proteasome assembly (GO:0043248)3.73507115
12negative regulation of telomerase activity (GO:0051974)3.70939184
13histone exchange (GO:0043486)3.69915341
14CENP-A containing nucleosome assembly (GO:0034080)3.68748788
15IMP biosynthetic process (GO:0006188)3.66248017
16replication fork processing (GO:0031297)3.66197567
17regulation of water loss via skin (GO:0033561)3.65021248
18establishment of skin barrier (GO:0061436)3.64463252
19L-serine metabolic process (GO:0006563)3.61245878
20regulation of helicase activity (GO:0051095)3.60266018
21regulation of mitotic spindle checkpoint (GO:1903504)3.51567665
22regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51567665
23somatic diversification of immune receptors via somatic mutation (GO:0002566)3.46394937
24somatic hypermutation of immunoglobulin genes (GO:0016446)3.46394937
25ribosome assembly (GO:0042255)3.45688692
26keratinocyte development (GO:0003334)3.44837619
27sex determination (GO:0007530)3.39109369
28water-soluble vitamin biosynthetic process (GO:0042364)3.38151196
29lysine catabolic process (GO:0006554)3.37137879
30lysine metabolic process (GO:0006553)3.37137879
31mesenchymal cell differentiation involved in kidney development (GO:0072161)3.34356165
32mesenchymal cell differentiation involved in renal system development (GO:2001012)3.34356165
33DNA catabolic process, exonucleolytic (GO:0000738)3.32082309
34regulation of interleukin-8 secretion (GO:2000482)3.28804814
35hemidesmosome assembly (GO:0031581)3.28228078
36maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.26036613
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23690442
38face development (GO:0060324)3.23434229
39positive regulation of interleukin-8 secretion (GO:2000484)3.21621979
40positive regulation of male gonad development (GO:2000020)3.21444585
41lung-associated mesenchyme development (GO:0060484)3.21291429
42rRNA modification (GO:0000154)3.20420021
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.19497893
44synapsis (GO:0007129)3.18951116
45IMP metabolic process (GO:0046040)3.17391313
46telomere maintenance via telomerase (GO:0007004)3.17109795
47respiratory chain complex IV assembly (GO:0008535)3.15476754
48purine nucleobase biosynthetic process (GO:0009113)3.13277843
49mitotic metaphase plate congression (GO:0007080)3.13217980
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13122937
51nucleobase biosynthetic process (GO:0046112)3.11523176
52somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.11285446
53isotype switching (GO:0045190)3.11285446
54somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.11285446
55negative regulation of translation, ncRNA-mediated (GO:0040033)3.10341220
56regulation of translation, ncRNA-mediated (GO:0045974)3.10341220
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.10341220
58rRNA methylation (GO:0031167)3.09687550
59poly(A)+ mRNA export from nucleus (GO:0016973)3.07511429
60lactate metabolic process (GO:0006089)3.07013399
61desmosome organization (GO:0002934)3.06242486
62establishment of integrated proviral latency (GO:0075713)3.05935004
63branching involved in labyrinthine layer morphogenesis (GO:0060670)3.02914380
64DNA strand elongation involved in DNA replication (GO:0006271)3.02091021
65DNA strand renaturation (GO:0000733)3.01176557
66regulation of keratinocyte proliferation (GO:0010837)2.99138234
67response to X-ray (GO:0010165)2.98783440
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94600685
69glomerulus development (GO:0032835)2.94300585
70NIK/NF-kappaB signaling (GO:0038061)2.93508081
71spindle checkpoint (GO:0031577)2.93394250
72ganglion development (GO:0061548)2.90616644
73glandular epithelial cell differentiation (GO:0002067)2.88845923
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88804839
75mitochondrial RNA metabolic process (GO:0000959)2.87946384
76maturation of 5.8S rRNA (GO:0000460)2.87559106
77mitotic spindle checkpoint (GO:0071174)2.87078018
78cullin deneddylation (GO:0010388)2.86510012
79diol metabolic process (GO:0034311)2.86359471
80dendritic cell chemotaxis (GO:0002407)2.86060539
81surfactant homeostasis (GO:0043129)2.85761599
82inner cell mass cell proliferation (GO:0001833)2.85712709
83DNA replication-dependent nucleosome organization (GO:0034723)2.85596061
84DNA replication-dependent nucleosome assembly (GO:0006335)2.85596061
85spindle assembly involved in mitosis (GO:0090307)2.85288469
86androgen biosynthetic process (GO:0006702)2.84770809
87DNA damage response, detection of DNA damage (GO:0042769)2.84409308
88telomere maintenance via semi-conservative replication (GO:0032201)2.83699000
89DNA strand elongation (GO:0022616)2.83294087
90DNA replication-independent nucleosome assembly (GO:0006336)2.83072821
91DNA replication-independent nucleosome organization (GO:0034724)2.83072821
92regulation of apoptotic process involved in morphogenesis (GO:1902337)2.80082578
93male sex determination (GO:0030238)2.79647913
94metaphase plate congression (GO:0051310)2.78996796
95regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78464799
96glycine metabolic process (GO:0006544)2.78406042
97dendritic cell migration (GO:0036336)2.77559446
98aspartate family amino acid catabolic process (GO:0009068)2.76092675
99cytochrome complex assembly (GO:0017004)2.76001080
100response to hepatocyte growth factor (GO:0035728)2.75386723
101cellular response to hepatocyte growth factor stimulus (GO:0035729)2.75386723
102sphingoid metabolic process (GO:0046519)2.75246886
103regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.74207458
104multicellular organismal water homeostasis (GO:0050891)2.73532450
105regulation of centriole replication (GO:0046599)2.73428340
106protein neddylation (GO:0045116)2.72522558
107positive regulation of epidermal cell differentiation (GO:0045606)2.72423786
108kidney morphogenesis (GO:0060993)2.72357822
109recombinational repair (GO:0000725)2.71973957
110double-strand break repair via homologous recombination (GO:0000724)2.71443192
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70691882
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70691882
113negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70691882
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.70691882
115negative regulation of sister chromatid segregation (GO:0033046)2.70691882
116transcription from mitochondrial promoter (GO:0006390)2.68141002
117regulation of chemokine secretion (GO:0090196)2.68087607
118pseudouridine synthesis (GO:0001522)2.67904028
119negative regulation of chromosome segregation (GO:0051985)2.67734369
120mitochondrial respiratory chain complex assembly (GO:0033108)2.66967150
121glomerular basement membrane development (GO:0032836)2.66738441
122regulation of meiosis I (GO:0060631)2.65086682
123neural crest cell development (GO:0014032)2.63949140
124branched-chain amino acid catabolic process (GO:0009083)2.63708866
125sphingosine metabolic process (GO:0006670)2.62534316
126positive regulation of glycoprotein biosynthetic process (GO:0010560)2.62439898
127telomere maintenance via telomere lengthening (GO:0010833)2.62051612
128intestinal epithelial cell development (GO:0060576)2.62043543
129negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61694220
130negative regulation of ligase activity (GO:0051352)2.61694220
131protein deneddylation (GO:0000338)2.61177781
132lung secretory cell differentiation (GO:0061140)2.60800873
133somatic recombination of immunoglobulin gene segments (GO:0016447)2.60625332
134muscle atrophy (GO:0014889)2.60593394
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.60151096
136NADH dehydrogenase complex assembly (GO:0010257)2.60151096
137mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60151096
138RNA-dependent DNA replication (GO:0006278)2.59979424
139single strand break repair (GO:0000012)2.59582570
140sulfate transport (GO:0008272)2.59479229
141protein localization to kinetochore (GO:0034501)2.58783115
142positive regulation of calcium ion import (GO:0090280)2.58316150
143establishment of protein localization to mitochondrial membrane (GO:0090151)2.57994574
144mitotic recombination (GO:0006312)2.57485672
145protein complex biogenesis (GO:0070271)2.57485362
146CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.57279562
147T-helper cell differentiation (GO:0042093)2.57279562
148myoblast migration (GO:0051451)2.56771313
149energy homeostasis (GO:0097009)2.56489225
150detection of bacterium (GO:0016045)2.56191840
151cell differentiation involved in metanephros development (GO:0072202)2.55063737
152calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.53332675
153negative regulation of stem cell proliferation (GO:2000647)2.52854481
154UDP-N-acetylglucosamine metabolic process (GO:0006047)2.50371303
155retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49787598
156phospholipid scrambling (GO:0017121)2.48644059
157sulfate transmembrane transport (GO:1902358)2.47456900
158cornea development in camera-type eye (GO:0061303)2.47161200
159detection of other organism (GO:0098543)2.46790356
160response to muramyl dipeptide (GO:0032495)2.46335923
161oligosaccharide catabolic process (GO:0009313)2.46038725
162female gonad development (GO:0008585)2.43787262
163columnar/cuboidal epithelial cell development (GO:0002066)2.43422292
164embryonic digestive tract morphogenesis (GO:0048557)2.43000263
165striated muscle atrophy (GO:0014891)2.41770886
166positive regulation of cellular amide metabolic process (GO:0034250)2.41299549
167regulation of cellular extravasation (GO:0002691)2.39760406
168bone remodeling (GO:0046849)2.39475923
169lymph vessel development (GO:0001945)2.37517203
170keratinocyte differentiation (GO:0030216)2.35451927
171negative regulation of necrotic cell death (GO:0060547)2.34581097
172regulation of somitogenesis (GO:0014807)2.34120157
173cellular response to vitamin D (GO:0071305)2.34115962
174maintenance of gastrointestinal epithelium (GO:0030277)2.33774172
175fucose catabolic process (GO:0019317)2.33432423
176L-fucose metabolic process (GO:0042354)2.33432423
177L-fucose catabolic process (GO:0042355)2.33432423
178positive regulation of vascular permeability (GO:0043117)2.33390944
179chemical homeostasis within a tissue (GO:0048875)2.32725653
180oocyte development (GO:0048599)2.32529781
181positive regulation of keratinocyte differentiation (GO:0045618)2.32303125
182G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.31038632
183negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.30870922
184atrioventricular valve morphogenesis (GO:0003181)2.30043775
185superoxide anion generation (GO:0042554)2.29560800
186branching involved in mammary gland duct morphogenesis (GO:0060444)2.27400324
187regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.26265602
188mesenchymal cell development (GO:0014031)2.25920543
189cardiac right ventricle morphogenesis (GO:0003215)2.25602598
190histone H3-K36 demethylation (GO:0070544)2.22897510
191cell surface receptor signaling pathway involved in heart development (GO:0061311)2.21854815
192alpha-beta T cell differentiation involved in immune response (GO:0002293)2.20840408
193alpha-beta T cell activation involved in immune response (GO:0002287)2.20840408
194T cell differentiation involved in immune response (GO:0002292)2.20840408
195keratinocyte proliferation (GO:0043616)2.19900386
196drinking behavior (GO:0042756)2.19599038
197replicative senescence (GO:0090399)2.17270567
198positive regulation of antigen processing and presentation (GO:0002579)2.14811937
199smooth muscle tissue development (GO:0048745)2.14799767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.73305163
2E2F7_22180533_ChIP-Seq_HELA_Human5.81491438
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04035480
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20371952
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.13121069
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.08641088
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.07957641
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.00105151
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97861716
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.79268158
11ZNF274_21170338_ChIP-Seq_K562_Hela2.73801320
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.53567540
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48264628
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.27774950
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27536556
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.16386910
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15180071
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.12821114
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.12199887
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.11468030
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.11468030
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.11468030
23FUS_26573619_Chip-Seq_HEK293_Human2.10212029
24ELK1_19687146_ChIP-ChIP_HELA_Human2.07098779
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05098435
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03505194
27CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01845766
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99232073
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.98035845
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97048947
31EWS_26573619_Chip-Seq_HEK293_Human1.96511173
32AR_21909140_ChIP-Seq_LNCAP_Human1.92708249
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89829232
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83310385
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80662518
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79110326
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.77581174
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.76307632
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72583110
40MYC_18940864_ChIP-ChIP_HL60_Human1.72470135
41NANOG_16153702_ChIP-ChIP_HESCs_Human1.72442264
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72185856
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70542108
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69273586
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.68759353
46P300_19829295_ChIP-Seq_ESCs_Human1.68675047
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68169307
48SOX2_20726797_ChIP-Seq_SW620_Human1.65353737
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65334299
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.65273740
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.63967312
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59476588
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.54089904
54AHR_22903824_ChIP-Seq_MCF-7_Human1.51787580
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.50813866
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50348798
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50348798
58* GATA4_25053715_ChIP-Seq_YYC3_Human1.50022153
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49740859
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.49507825
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48509287
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47088111
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46705386
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.45618261
65FOXP3_21729870_ChIP-Seq_TREG_Human1.45405188
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.44639461
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44472479
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43113778
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43014777
70VDR_23849224_ChIP-Seq_CD4+_Human1.42899785
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.42729203
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42076699
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40802927
74TP53_18474530_ChIP-ChIP_U2OS_Human1.39727430
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39103816
76CJUN_26792858_Chip-Seq_BT549_Human1.38031892
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.36645038
78VDR_22108803_ChIP-Seq_LS180_Human1.36448051
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.35037290
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34232502
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.33579267
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33514921
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.33310701
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32355757
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30218797
86RNF2_27304074_Chip-Seq_NSC_Mouse1.29909916
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29478968
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.29401323
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.28720378
90TAF15_26573619_Chip-Seq_HEK293_Human1.28230103
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27299733
92P53_22387025_ChIP-Seq_ESCs_Mouse1.27205493
93ZFX_18555785_Chip-Seq_ESCs_Mouse1.26784967
94* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26395307
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26003135
96BP1_19119308_ChIP-ChIP_Hs578T_Human1.25905343
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.25713781
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25526702
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25285908
100IRF1_19129219_ChIP-ChIP_H3396_Human1.22944997
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.22265207
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21985681
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21527292
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21522211
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.21236438
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21039568
107E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20829053
108IGF1R_20145208_ChIP-Seq_DFB_Human1.20337900
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20079227
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18168393
111P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17631980
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.17594516
113KLF5_25053715_ChIP-Seq_YYC3_Human1.17503470
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17479252
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17022542
116SOX2_18555785_Chip-Seq_ESCs_Mouse1.15884286
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.15397277
118P300_18555785_Chip-Seq_ESCs_Mouse1.14806671
119SALL1_21062744_ChIP-ChIP_HESCs_Human1.14296878
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13903498
121KLF4_18555785_Chip-Seq_ESCs_Mouse1.12731193
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12533458
123ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12228242
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11691226
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11637198
126CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11360486
127ARNT_22903824_ChIP-Seq_MCF-7_Human1.11087752
128PU1_27457419_Chip-Seq_LIVER_Mouse1.10513714
129MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09944259
130GBX2_23144817_ChIP-Seq_PC3_Human1.09442943
131MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09317760
132EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08937680
133SMAD3_21741376_ChIP-Seq_HESCs_Human1.07319632
134TP63_19390658_ChIP-ChIP_HaCaT_Human1.06878368
135BCAT_22108803_ChIP-Seq_LS180_Human1.06364826
136SOX2_19829295_ChIP-Seq_ESCs_Human1.05969655
137NANOG_19829295_ChIP-Seq_ESCs_Human1.05969655
138YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05593902
139RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05284451
140NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04776501
141CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02788529
142PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01698858
143CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01316224
144MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01278543
145WT1_19549856_ChIP-ChIP_CCG9911_Human1.00981476
146KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00784580
147TP53_16413492_ChIP-PET_HCT116_Human1.00317545
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99732977
149CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99186671
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99097272
151IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98741207
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98392341
153CTCF_18555785_Chip-Seq_ESCs_Mouse0.97620074
154RNF2_27304074_Chip-Seq_ESCs_Mouse0.97238406
155EP300_21415370_ChIP-Seq_HL-1_Mouse0.96594108
156SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96549043
157CRX_20693478_ChIP-Seq_RETINA_Mouse0.96064409
158OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95558098
159AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95498963
160SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95380038
161MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95246958
162TCF4_22108803_ChIP-Seq_LS180_Human0.94749518
163STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94212056
164TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93575981
165PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93189350
166ER_23166858_ChIP-Seq_MCF-7_Human0.93154003
167EZH2_27304074_Chip-Seq_ESCs_Mouse0.93004308
168SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92691770
169UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91831230
170EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91526423
171TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91066898
172TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90944900
173CDX2_22108803_ChIP-Seq_LS180_Human0.90253832
174TTF2_22483619_ChIP-Seq_HELA_Human0.89776042
175FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89014337
176FOXA1_25329375_ChIP-Seq_VCAP_Human0.89014337
177HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88970715
178MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88539522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.07915179
2MP0003941_abnormal_skin_development3.65432982
3MP0010094_abnormal_chromosome_stability3.57796839
4MP0008877_abnormal_DNA_methylation3.56297597
5MP0003195_calcinosis3.51976905
6MP0002009_preneoplasia3.51776114
7MP0008058_abnormal_DNA_repair3.34595253
8MP0002138_abnormal_hepatobiliary_system3.31558774
9MP0002254_reproductive_system_inflammat3.23109499
10MP0003718_maternal_effect2.98187386
11MP0004957_abnormal_blastocyst_morpholog2.85411083
12MP0000566_synostosis2.80080857
13MP0001346_abnormal_lacrimal_gland2.65940370
14MP0003111_abnormal_nucleus_morphology2.51776734
15MP0008007_abnormal_cellular_replicative2.45695619
16MP0003890_abnormal_embryonic-extraembry2.41880001
17MP0008995_early_reproductive_senescence2.37194098
18MP0008057_abnormal_DNA_replication2.27168670
19MP0002098_abnormal_vibrissa_morphology2.17319676
20MP0008932_abnormal_embryonic_tissue2.17208241
21MP0003878_abnormal_ear_physiology2.13306888
22MP0005377_hearing/vestibular/ear_phenot2.13306888
23MP0008004_abnormal_stomach_pH2.07652650
24MP0000383_abnormal_hair_follicle1.98094315
25MP0002277_abnormal_respiratory_mucosa1.95163121
26MP0004264_abnormal_extraembryonic_tissu1.95027398
27MP0005171_absent_coat_pigmentation1.94232843
28MP0001873_stomach_inflammation1.91259139
29MP0003119_abnormal_digestive_system1.88339639
30MP0004272_abnormal_basement_membrane1.86841387
31MP0001188_hyperpigmentation1.85227747
32MP0001879_abnormal_lymphatic_vessel1.84440349
33MP0010678_abnormal_skin_adnexa1.78932375
34MP0003806_abnormal_nucleotide_metabolis1.75205822
35MP0005310_abnormal_salivary_gland1.72722826
36MP0000613_abnormal_salivary_gland1.69387149
37MP0003567_abnormal_fetal_cardiomyocyte1.69367828
38MP0000462_abnormal_digestive_system1.68370946
39MP0003077_abnormal_cell_cycle1.65370774
40MP0009379_abnormal_foot_pigmentation1.65008905
41MP0004133_heterotaxia1.55635559
42MP0000678_abnormal_parathyroid_gland1.54975103
43MP0010234_abnormal_vibrissa_follicle1.54757269
44MP0000516_abnormal_urinary_system1.54357106
45MP0005367_renal/urinary_system_phenotyp1.54357106
46MP0005623_abnormal_meninges_morphology1.54070795
47MP0000467_abnormal_esophagus_morphology1.52583436
48MP0002060_abnormal_skin_morphology1.50853236
49MP0000470_abnormal_stomach_morphology1.50618884
50MP0003121_genomic_imprinting1.48592639
51MP0000762_abnormal_tongue_morphology1.46795521
52MP0003123_paternal_imprinting1.46511449
53MP0005395_other_phenotype1.46190049
54MP0002751_abnormal_autonomic_nervous1.45467040
55MP0003646_muscle_fatigue1.43762220
56MP0010155_abnormal_intestine_physiology1.43176505
57MP0002877_abnormal_melanocyte_morpholog1.42393818
58MP0002163_abnormal_gland_morphology1.40011421
59MP0000579_abnormal_nail_morphology1.38004191
60MP0009384_cardiac_valve_regurgitation1.37620173
61MP0008872_abnormal_physiological_respon1.37549950
62MP0002796_impaired_skin_barrier1.37171297
63MP0005670_abnormal_white_adipose1.36770076
64MP0005360_urolithiasis1.36291217
65MP0003045_fibrosis1.36255122
66MP0000537_abnormal_urethra_morphology1.34949525
67MP0010352_gastrointestinal_tract_polyps1.34459145
68MP0009697_abnormal_copulation1.34054694
69MP0004782_abnormal_surfactant_physiolog1.32321514
70MP0005275_abnormal_skin_tensile1.30859424
71MP0001293_anophthalmia1.26637543
72MP0004381_abnormal_hair_follicle1.22840514
73MP0003866_abnormal_defecation1.22553971
74MP0002166_altered_tumor_susceptibility1.21597200
75MP0002249_abnormal_larynx_morphology1.20720765
76MP0001958_emphysema1.19096931
77MP0001216_abnormal_epidermal_layer1.18783085
78MP0003453_abnormal_keratinocyte_physiol1.17544459
79MP0006035_abnormal_mitochondrial_morpho1.15636637
80MP0000490_abnormal_crypts_of1.13107116
81MP0003283_abnormal_digestive_organ1.12894882
82MP0004147_increased_porphyrin_level1.12475347
83MP0005551_abnormal_eye_electrophysiolog1.12227545
84MP0001666_abnormal_nutrient_absorption1.12108510
85MP0005379_endocrine/exocrine_gland_phen1.12021462
86MP0002006_tumorigenesis1.10985225
87MP0005332_abnormal_amino_acid1.09577096
88MP0003315_abnormal_perineum_morphology1.08919833
89MP0002084_abnormal_developmental_patter1.08838206
90MP0003136_yellow_coat_color1.08185550
91MP0006036_abnormal_mitochondrial_physio1.07244468
92MP0005085_abnormal_gallbladder_physiolo1.05289643
93MP0002160_abnormal_reproductive_system1.05044079
94MP0001697_abnormal_embryo_size1.04627152
95MP0005084_abnormal_gallbladder_morpholo1.03995724
96MP0001730_embryonic_growth_arrest1.03284986
97MP0002736_abnormal_nociception_after1.02128548
98MP0003786_premature_aging1.01790772
99MP0010307_abnormal_tumor_latency1.01500319
100MP0005167_abnormal_blood-brain_barrier1.00615106
101MP0002085_abnormal_embryonic_tissue0.99667588
102MP0002102_abnormal_ear_morphology0.99552385
103MP0010030_abnormal_orbit_morphology0.99403547
104MP0002148_abnormal_hypersensitivity_rea0.99100302
105MP0010386_abnormal_urinary_bladder0.99089314
106MP0004215_abnormal_myocardial_fiber0.98667993
107MP0001661_extended_life_span0.97858845
108MP0000377_abnormal_hair_follicle0.97821595
109MP0003011_delayed_dark_adaptation0.97318484
110MP0003936_abnormal_reproductive_system0.97025511
111MP0002876_abnormal_thyroid_physiology0.96976918
112MP0003300_gastrointestinal_ulcer0.96571867
113MP0000049_abnormal_middle_ear0.96285873
114MP0005645_abnormal_hypothalamus_physiol0.96032542
115MP0002938_white_spotting0.95735830
116MP0009672_abnormal_birth_weight0.95210292
117MP0001177_atelectasis0.94535891
118MP0010368_abnormal_lymphatic_system0.94290815
119MP0005501_abnormal_skin_physiology0.94164163
120MP0005248_abnormal_Harderian_gland0.93340109
121MP0001929_abnormal_gametogenesis0.90076149
122MP0002233_abnormal_nose_morphology0.89790948
123MP0005508_abnormal_skeleton_morphology0.88861569
124MP0006072_abnormal_retinal_apoptosis0.88520577
125MP0002837_dystrophic_cardiac_calcinosis0.88334121
126MP0008875_abnormal_xenobiotic_pharmacok0.86356214
127MP0001984_abnormal_olfaction0.86059046
128MP0003186_abnormal_redox_activity0.85806188
129MP0000026_abnormal_inner_ear0.84521513
130MP0003385_abnormal_body_wall0.84318389
131MP0001485_abnormal_pinna_reflex0.83790869
132MP0003566_abnormal_cell_adhesion0.83172839
133MP0006054_spinal_hemorrhage0.82944308
134MP0001672_abnormal_embryogenesis/_devel0.82876465
135MP0005380_embryogenesis_phenotype0.82876465
136MP0003937_abnormal_limbs/digits/tail_de0.82658673
137MP0002132_abnormal_respiratory_system0.82452791
138MP0005365_abnormal_bile_salt0.82255110
139MP0000681_abnormal_thyroid_gland0.81799847
140MP0008789_abnormal_olfactory_epithelium0.81473223
141MP0001664_abnormal_digestion0.81084170
142MP0000538_abnormal_urinary_bladder0.80216732
143MP0000653_abnormal_sex_gland0.79618729
144MP0002111_abnormal_tail_morphology0.79249431
145MP0003755_abnormal_palate_morphology0.79101025
146MP0001145_abnormal_male_reproductive0.78955652
147MP0005381_digestive/alimentary_phenotyp0.78810757
148MP0001191_abnormal_skin_condition0.77741390
149MP0001764_abnormal_homeostasis0.77480242
150MP0000432_abnormal_head_morphology0.77007615
151MP0002210_abnormal_sex_determination0.76505861
152MP0005253_abnormal_eye_physiology0.75295310
153MP0000627_abnormal_mammary_gland0.74621122
154MP0004197_abnormal_fetal_growth/weight/0.73491641
155MP0000647_abnormal_sebaceous_gland0.73329863
156MP0001529_abnormal_vocalization0.73114814
157MP0001119_abnormal_female_reproductive0.72456992
158MP0006292_abnormal_olfactory_placode0.72143738
159MP0003091_abnormal_cell_migration0.70941868
160MP0000350_abnormal_cell_proliferation0.70617630
161MP0003787_abnormal_imprinting0.70602428
162MP0001286_abnormal_eye_development0.70474209
163MP0000477_abnormal_intestine_morphology0.70182202
164MP0000631_abnormal_neuroendocrine_gland0.70159992
165MP0003724_increased_susceptibility_to0.69693047
166MP0005646_abnormal_pituitary_gland0.69636156
167MP0009703_decreased_birth_body0.69538089
168MP0002282_abnormal_trachea_morphology0.69491817
169MP0008775_abnormal_heart_ventricle0.68984622
170MP0003137_abnormal_impulse_conducting0.67842836
171MP0005389_reproductive_system_phenotype0.67815294
172MP0001270_distended_abdomen0.67768952
173MP0005451_abnormal_body_composition0.67503870
174MP0004019_abnormal_vitamin_homeostasis0.66842335
175MP0005647_abnormal_sex_gland0.66309290
176MP0000372_irregular_coat_pigmentation0.64851319

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.23242473
2Aplasia cutis congenita (HP:0001057)4.00667647
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.97381648
4Chromsome breakage (HP:0040012)3.57707169
5Ectopic kidney (HP:0000086)3.48486489
6Stenosis of the external auditory canal (HP:0000402)3.45782331
7Colon cancer (HP:0003003)3.39050011
8Meckel diverticulum (HP:0002245)3.37407493
9Congenital sensorineural hearing impairment (HP:0008527)3.32819241
10Ependymoma (HP:0002888)3.29075546
11Duplicated collecting system (HP:0000081)3.25600106
12Prostate neoplasm (HP:0100787)3.24123465
13Abnormality of the ileum (HP:0001549)3.23467364
14Abnormality of chromosome stability (HP:0003220)3.17730153
15Right ventricular cardiomyopathy (HP:0011663)3.13608964
16Abnormal sex determination (HP:0012244)3.05310541
17Sex reversal (HP:0012245)3.05310541
18Abnormality of the renal collecting system (HP:0004742)3.01655120
19Carpal bone hypoplasia (HP:0001498)2.96089009
20Lip pit (HP:0100267)2.95489578
21Abnormality of glycine metabolism (HP:0010895)2.89021184
22Abnormality of serine family amino acid metabolism (HP:0010894)2.89021184
23Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.84958783
24Short 1st metacarpal (HP:0010034)2.84958783
25Birth length less than 3rd percentile (HP:0003561)2.83480354
26Hyperglycinuria (HP:0003108)2.80365602
27Onycholysis (HP:0001806)2.74992360
28Abnormality of aspartate family amino acid metabolism (HP:0010899)2.68947059
29Absent thumb (HP:0009777)2.68589516
30Abnormality of serum amino acid levels (HP:0003112)2.67086248
31Pendular nystagmus (HP:0012043)2.64783023
32Glioma (HP:0009733)2.60354939
33Hyperglycinemia (HP:0002154)2.59330744
34Absent radius (HP:0003974)2.59147970
35Abnormality of the 1st metacarpal (HP:0010009)2.57331687
36Acute encephalopathy (HP:0006846)2.55460012
37Methylmalonic acidemia (HP:0002912)2.53766556
38Astrocytoma (HP:0009592)2.50276334
39Abnormality of the astrocytes (HP:0100707)2.50276334
40Horseshoe kidney (HP:0000085)2.48995323
41Small intestinal stenosis (HP:0012848)2.47983439
42Duodenal stenosis (HP:0100867)2.47983439
43Abnormality of the parathyroid morphology (HP:0011766)2.46206274
44Acute necrotizing encephalopathy (HP:0006965)2.45949309
45Absent forearm bone (HP:0003953)2.45287314
46Aplasia involving forearm bones (HP:0009822)2.45287314
47Stomach cancer (HP:0012126)2.44931786
48Atrophic scars (HP:0001075)2.44919137
49Fused cervical vertebrae (HP:0002949)2.43664999
50Neoplasm of the adrenal gland (HP:0100631)2.42574246
51Upper limb muscle weakness (HP:0003484)2.38463943
52Aplasia/hypoplasia of the uterus (HP:0008684)2.36592380
53Popliteal pterygium (HP:0009756)2.34633601
54Rectovaginal fistula (HP:0000143)2.34560698
55Rectal fistula (HP:0100590)2.34560698
56Male pseudohermaphroditism (HP:0000037)2.33690945
57Fragile nails (HP:0001808)2.32961643
58Short hallux (HP:0010109)2.32050667
59Duplication of thumb phalanx (HP:0009942)2.31650959
60Methylmalonic aciduria (HP:0012120)2.31041855
61Abnormality of the duodenum (HP:0002246)2.30466215
62Rhabdomyosarcoma (HP:0002859)2.27311252
63Clubbing of toes (HP:0100760)2.25225915
6411 pairs of ribs (HP:0000878)2.24856680
65Hypoplasia of dental enamel (HP:0006297)2.24562399
66Progressive macrocephaly (HP:0004481)2.24290213
67Abnormality of the carotid arteries (HP:0005344)2.23554508
68Distal lower limb muscle weakness (HP:0009053)2.23524197
69Congenital ichthyosiform erythroderma (HP:0007431)2.23225779
70White forelock (HP:0002211)2.23029861
71Pancreatic cysts (HP:0001737)2.22671468
72Aplasia/Hypoplasia of the hallux (HP:0008362)2.21199940
73Abolished electroretinogram (ERG) (HP:0000550)2.20751481
74Symptomatic seizures (HP:0011145)2.19966112
75Abnormality of the vitamin B12 metabolism (HP:0004341)2.19741163
76Abnormality of vitamin B metabolism (HP:0004340)2.18463128
77Hypoplasia of the iris (HP:0007676)2.18369647
78Abnormality of the nasal septum (HP:0000419)2.17818947
79Azoospermia (HP:0000027)2.15346982
80Triphalangeal thumb (HP:0001199)2.15260631
81Hypoplasia of the uterus (HP:0000013)2.15098514
82Neoplasm of the adrenal cortex (HP:0100641)2.14615536
83Abnormal lung lobation (HP:0002101)2.14603629
84Milia (HP:0001056)2.14537268
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.12882458
86Tubulointerstitial nephritis (HP:0001970)2.12721115
87Pulmonary artery stenosis (HP:0004415)2.09524940
88Sloping forehead (HP:0000340)2.08355479
89Patchy hypopigmentation of hair (HP:0011365)2.07057502
90Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05051343
91Posterior subcapsular cataract (HP:0007787)2.03728362
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03496465
93Metabolic alkalosis (HP:0200114)2.03419832
94Abnormal mitochondria in muscle tissue (HP:0008316)2.01134430
95Multiple enchondromatosis (HP:0005701)2.00147114
96Abnormality of methionine metabolism (HP:0010901)1.99102239
97Neonatal short-limb short stature (HP:0008921)1.98619083
98Xerostomia (HP:0000217)1.98383003
99Hyperactive renin-angiotensin system (HP:0000841)1.98008829
100Abnormality of male internal genitalia (HP:0000022)1.96923620
101Nephroblastoma (Wilms tumor) (HP:0002667)1.95988409
102Cheilitis (HP:0100825)1.95514582
103Abnormality of the gastric mucosa (HP:0004295)1.95232145
104Neoplasm of the oral cavity (HP:0100649)1.94792164
105Vaginal fistula (HP:0004320)1.94062192
106Natal tooth (HP:0000695)1.93613476
107Abnormality of chloride homeostasis (HP:0011422)1.91977657
108Fragile skin (HP:0001030)1.91479337
109Pancreatic fibrosis (HP:0100732)1.88904605
110Cerebral edema (HP:0002181)1.88831501
111Increased CSF lactate (HP:0002490)1.88637486
112Short thumb (HP:0009778)1.88427179
113Embryonal renal neoplasm (HP:0011794)1.88195569
114Hyperphosphatemia (HP:0002905)1.88105016
115Bilateral microphthalmos (HP:0007633)1.86769410
116Breast carcinoma (HP:0003002)1.86524846
117Plantar hyperkeratosis (HP:0007556)1.86395299
118Reticulocytopenia (HP:0001896)1.86013885
119Portal hypertension (HP:0001409)1.84990086
120Curly hair (HP:0002212)1.84122832
121Premature loss of primary teeth (HP:0006323)1.83739698
122Retrobulbar optic neuritis (HP:0100654)1.83659468
123Optic neuritis (HP:0100653)1.83659468
124Chronic hepatic failure (HP:0100626)1.83620994
125Intestinal atresia (HP:0011100)1.83538777
126Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79397086
127Mitochondrial inheritance (HP:0001427)1.78826127
128Chorioretinal atrophy (HP:0000533)1.77513190
129Biliary tract neoplasm (HP:0100574)1.77229793
130Abnormality of the hepatic vasculature (HP:0006707)1.76818661
131Intestinal fistula (HP:0100819)1.76797293
132Corneal erosion (HP:0200020)1.76641906
133Meningioma (HP:0002858)1.76490174
134Volvulus (HP:0002580)1.75826513
135Pancreatic islet-cell hyperplasia (HP:0004510)1.74758877
136Congenital, generalized hypertrichosis (HP:0004540)1.74644820
137Chronic diarrhea (HP:0002028)1.73829507
138Short thorax (HP:0010306)1.73558860
139Decreased circulating renin level (HP:0003351)1.73349947
140Absent/shortened dynein arms (HP:0200106)1.73102458
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.73102458
142Gastrointestinal atresia (HP:0002589)1.71138187
143Septo-optic dysplasia (HP:0100842)1.70975239
144Hyperinsulinemic hypoglycemia (HP:0000825)1.70794327
145Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70541332
146Abnormality of vitamin metabolism (HP:0100508)1.70401022
147Neoplasm of the colon (HP:0100273)1.69830774
148Congenital hepatic fibrosis (HP:0002612)1.68510268
149Hypothermia (HP:0002045)1.68252789
150Parakeratosis (HP:0001036)1.68138468
151Aplasia/Hypoplasia of the uvula (HP:0010293)1.67997488
152Abnormal ciliary motility (HP:0012262)1.67519938
153Conical tooth (HP:0000698)1.67506036
154Abnormality of alanine metabolism (HP:0010916)1.67367665
155Hyperalaninemia (HP:0003348)1.67367665
156Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67367665
157Abnormality of molar (HP:0011077)1.67205157
158Abnormality of molar morphology (HP:0011070)1.67205157
159Short phalanx of the thumb (HP:0009660)1.66980830
160Lethargy (HP:0001254)1.66836095
161Amelogenesis imperfecta (HP:0000705)1.66145091
162Unilateral renal agenesis (HP:0000122)1.66072469
163Abnormality of pyrimidine metabolism (HP:0004353)1.64646850
164Osteomalacia (HP:0002749)1.64494072
165Progressive sensorineural hearing impairment (HP:0000408)1.64344375
166Megaloblastic anemia (HP:0001889)1.64321140
167True hermaphroditism (HP:0010459)1.64246230
168Absent hand (HP:0004050)1.63765279
169Hypoglycemic seizures (HP:0002173)1.62992858
170Aplasia/hypoplasia of the humerus (HP:0006507)1.62707320
171Anhidrosis (HP:0000970)1.62342012
172Optic nerve hypoplasia (HP:0000609)1.62304777
173Adactyly (HP:0009776)1.61558595
174Ectropion (HP:0000656)1.61484390
175Abnormality of the axillary hair (HP:0100134)1.61287590
176Abnormality of secondary sexual hair (HP:0009888)1.61287590
177Median cleft lip (HP:0000161)1.60689298
178Woolly hair (HP:0002224)1.60364660
179Abnormality of DNA repair (HP:0003254)1.59134806
180Abnormality of the preputium (HP:0100587)1.58410984
181Renal cortical cysts (HP:0000803)1.58244388
182Stage 5 chronic kidney disease (HP:0003774)1.57398014
183Occipital encephalocele (HP:0002085)1.57189661
184Facial cleft (HP:0002006)1.55878857
185Nasolacrimal duct obstruction (HP:0000579)1.55636294
186Mildly elevated creatine phosphokinase (HP:0008180)1.55598242
187Increased IgE level (HP:0003212)1.55338886
188Abnormality of calcium-phosphate metabolism (HP:0100530)1.54555323
189Widely patent fontanelles and sutures (HP:0004492)1.53616040
190Partial duplication of thumb phalanx (HP:0009944)1.53539920
191Ileus (HP:0002595)1.53217189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.94526791
2EPHA23.30934600
3BUB13.30076871
4TSSK63.13227566
5MAPK153.10529952
6ACVR1B3.01673102
7TRIM282.87193610
8MAP3K142.82825505
9PLK32.49459191
10PBK2.44124817
11INSRR2.42587658
12VRK22.36370562
13CDC72.35780946
14NUAK12.22516836
15STK38L2.18281521
16BRSK22.14793163
17EPHB22.14379139
18ZAK2.13308009
19TAF12.03716456
20GRK11.94316356
21IRAK31.92985902
22EIF2AK31.90602401
23TRPM71.84068621
24TNIK1.77960371
25FRK1.75945074
26MST41.75831893
27MST1R1.74408630
28PTK61.67175639
29NEK11.61660407
30EPHB11.60866175
31PIK3CG1.60430195
32LATS11.57824563
33AKT31.57506134
34OXSR11.51882201
35CHUK1.50234365
36PLK11.49107473
37IKBKB1.45181979
38TIE11.44822674
39MYLK1.42647055
40MAP4K21.41150674
41MAP2K21.40292749
42STK241.37501250
43VRK11.37291066
44IRAK41.36488504
45EIF2AK21.36224281
46YES11.34515278
47IKBKE1.34235900
48NLK1.33685374
49EIF2AK11.32496108
50BMPR1B1.31284590
51PLK21.27826894
52FER1.19726653
53CDK121.13242478
54IRAK11.11482771
55WEE11.11065923
56JAK31.10683133
57STK391.09350484
58EPHA31.07318980
59NEK61.07185537
60TGFBR11.06315159
61NME11.02666265
62PIK3CA1.02408065
63PTK21.02240379
64BLK1.00657548
65BCR0.96104159
66CSNK1G10.92807849
67STK30.92218405
68ATR0.90517988
69WNK40.89126509
70BRSK10.87883959
71PRKAA20.87632996
72MKNK20.87619946
73MET0.86585183
74TYK20.83729795
75FGFR20.83138401
76ERBB30.79602023
77CDK70.79146599
78MAP3K20.78659026
79PRKD20.78286177
80TGFBR20.76948424
81MAP3K30.75782948
82ADRBK20.75524911
83DYRK20.75044825
84CSK0.74312321
85FGFR10.73630079
86PDK20.73416712
87TXK0.71887323
88PKN10.71456187
89ATM0.71374157
90RIPK10.71241936
91CHEK20.71000340
92DDR20.70877807
93PRKCE0.69977446
94PASK0.69193671
95CDK30.66594974
96DMPK0.63264325
97PRKG20.62675091
98STK40.61569363
99KDR0.60224037
100ALK0.60042184
101GRK70.59872361
102CDC42BPA0.59851782
103BMPR20.59002638
104BRD40.58429108
105LMTK20.58344104
106CDK90.58182510
107AURKB0.57223948
108DAPK10.56951144
109TEC0.55966615
110PINK10.55712213
111MKNK10.55363901
112WNK10.55287981
113GSK3A0.54272349
114TAOK30.53903795
115PRKCG0.53814412
116CSNK1G30.53664189
117CSNK1G20.53144962
118PIM10.52856531
119JAK10.52618170
120ERBB40.49269485
121MELK0.49130845
122BCKDK0.48639922
123DYRK30.46319954
124TBK10.45728177
125TTK0.45634193
126RPS6KB20.45475605
127FGFR30.45429867
128WNK30.45059996
129PHKG10.44708334
130PHKG20.44708334
131CHEK10.44370190
132PDGFRA0.43933457
133CSNK1A1L0.43279018
134STK160.42539378
135CSNK2A10.41791471
136MAPK130.41315494
137MUSK0.40990201
138OBSCN0.40558396
139SRPK10.39816557
140MAPKAPK20.39801190
141MAP2K60.38963253
142FLT30.38721947
143FGFR40.38675280
144PAK30.38283589
145BTK0.37937911
146PRKCI0.37867469
147PRKDC0.37387998
148AKT10.37331104
149ERBB20.36167483
150PLK40.36104651
151NEK20.35382477
152SIK30.34291691
153CSNK1A10.33994314
154CSNK1E0.33519148
155TLK10.29622216
156CDK10.24658962
157CSNK2A20.24562196
158MAPKAPK50.23485181
159CLK10.21654319
160ADRBK10.19681616
161PAK40.18854124

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.13459324
2Non-homologous end-joining_Homo sapiens_hsa034502.68780390
3Mismatch repair_Homo sapiens_hsa034302.64279547
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49322933
5DNA replication_Homo sapiens_hsa030302.45464200
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.30809632
7Propanoate metabolism_Homo sapiens_hsa006402.23509048
8Vitamin B6 metabolism_Homo sapiens_hsa007502.12098048
9Sphingolipid metabolism_Homo sapiens_hsa006002.05556100
10Sulfur metabolism_Homo sapiens_hsa009202.04762676
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00985095
12One carbon pool by folate_Homo sapiens_hsa006701.99168376
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97882215
14ECM-receptor interaction_Homo sapiens_hsa045121.94801412
15RNA polymerase_Homo sapiens_hsa030201.93689571
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.91189239
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89548784
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89522154
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86655951
20Selenocompound metabolism_Homo sapiens_hsa004501.84850931
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.84800248
22Protein digestion and absorption_Homo sapiens_hsa049741.77034588
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75819843
24Mineral absorption_Homo sapiens_hsa049781.75815049
25Arachidonic acid metabolism_Homo sapiens_hsa005901.75470468
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.71154634
27Autoimmune thyroid disease_Homo sapiens_hsa053201.64096521
28RNA degradation_Homo sapiens_hsa030181.64009929
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61938159
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61938144
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57964415
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57399028
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.54120303
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53955278
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50576659
36Fatty acid elongation_Homo sapiens_hsa000621.49195876
37Pyruvate metabolism_Homo sapiens_hsa006201.48523708
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47761869
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47012506
40Base excision repair_Homo sapiens_hsa034101.46335842
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.45014023
42Fanconi anemia pathway_Homo sapiens_hsa034601.44966638
43RNA transport_Homo sapiens_hsa030131.44758573
44Vitamin digestion and absorption_Homo sapiens_hsa049771.43798650
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42714918
46Steroid biosynthesis_Homo sapiens_hsa001001.42401161
47Linoleic acid metabolism_Homo sapiens_hsa005911.40459168
48Caffeine metabolism_Homo sapiens_hsa002321.40256308
49Other glycan degradation_Homo sapiens_hsa005111.39042066
50Adherens junction_Homo sapiens_hsa045201.38254784
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37829221
52Tight junction_Homo sapiens_hsa045301.37186536
53Small cell lung cancer_Homo sapiens_hsa052221.37077902
54Tryptophan metabolism_Homo sapiens_hsa003801.32772759
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32665272
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30660897
57Protein export_Homo sapiens_hsa030601.29453730
58Butanoate metabolism_Homo sapiens_hsa006501.28318922
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28240002
60Ovarian steroidogenesis_Homo sapiens_hsa049131.26375184
61Basal cell carcinoma_Homo sapiens_hsa052171.25626528
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24707885
63Ether lipid metabolism_Homo sapiens_hsa005651.22547534
64Glutathione metabolism_Homo sapiens_hsa004801.20674213
65Graft-versus-host disease_Homo sapiens_hsa053321.18781635
66Fatty acid degradation_Homo sapiens_hsa000711.18634681
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18222558
68Nucleotide excision repair_Homo sapiens_hsa034201.18029319
69Cell cycle_Homo sapiens_hsa041101.15547619
70Toxoplasmosis_Homo sapiens_hsa051451.12808145
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12411227
72Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12094537
73Hematopoietic cell lineage_Homo sapiens_hsa046401.10757754
74TNF signaling pathway_Homo sapiens_hsa046681.10533205
75Leukocyte transendothelial migration_Homo sapiens_hsa046701.09975226
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08912429
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08503994
78Allograft rejection_Homo sapiens_hsa053301.06374923
79Purine metabolism_Homo sapiens_hsa002301.05666390
80Notch signaling pathway_Homo sapiens_hsa043301.05450039
81Peroxisome_Homo sapiens_hsa041461.04849755
82Pyrimidine metabolism_Homo sapiens_hsa002401.04746343
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03461069
84TGF-beta signaling pathway_Homo sapiens_hsa043501.00031957
85Measles_Homo sapiens_hsa051620.97450973
86Hippo signaling pathway_Homo sapiens_hsa043900.97291749
87Hepatitis C_Homo sapiens_hsa051600.95359675
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.94148449
89Oxidative phosphorylation_Homo sapiens_hsa001900.93995931
90Focal adhesion_Homo sapiens_hsa045100.92265408
91Hedgehog signaling pathway_Homo sapiens_hsa043400.92024861
92Nitrogen metabolism_Homo sapiens_hsa009100.91926843
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.91446691
94Starch and sucrose metabolism_Homo sapiens_hsa005000.91206914
95Fatty acid metabolism_Homo sapiens_hsa012120.90104695
96beta-Alanine metabolism_Homo sapiens_hsa004100.89712582
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89682483
98Carbon metabolism_Homo sapiens_hsa012000.89048454
99Herpes simplex infection_Homo sapiens_hsa051680.87996707
100Parkinsons disease_Homo sapiens_hsa050120.86902014
101Phototransduction_Homo sapiens_hsa047440.86653029
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86156717
103Spliceosome_Homo sapiens_hsa030400.84925723
104Retinol metabolism_Homo sapiens_hsa008300.84924121
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84358929
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82617692
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81755329
108ABC transporters_Homo sapiens_hsa020100.81007404
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.80714281
110Arginine and proline metabolism_Homo sapiens_hsa003300.80652242
111Histidine metabolism_Homo sapiens_hsa003400.79382180
112Apoptosis_Homo sapiens_hsa042100.78302179
113Biosynthesis of amino acids_Homo sapiens_hsa012300.77480570
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.77264488
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76558592
116Pathways in cancer_Homo sapiens_hsa052000.76237323
117Influenza A_Homo sapiens_hsa051640.76039403
118p53 signaling pathway_Homo sapiens_hsa041150.75382001
119Metabolic pathways_Homo sapiens_hsa011000.74724759
120Basal transcription factors_Homo sapiens_hsa030220.74472418
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74120618
122Amoebiasis_Homo sapiens_hsa051460.73592467
123Leishmaniasis_Homo sapiens_hsa051400.72787317
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72395038
125Axon guidance_Homo sapiens_hsa043600.72273279
126MicroRNAs in cancer_Homo sapiens_hsa052060.72114054
127Prostate cancer_Homo sapiens_hsa052150.70517993
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70258919
129Pancreatic secretion_Homo sapiens_hsa049720.69205376
130Renin-angiotensin system_Homo sapiens_hsa046140.68575584
131Huntingtons disease_Homo sapiens_hsa050160.66517689
132Malaria_Homo sapiens_hsa051440.64949845
133Dorso-ventral axis formation_Homo sapiens_hsa043200.64863136
134Arginine biosynthesis_Homo sapiens_hsa002200.63959179
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63586712
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63073668
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61888898
138Homologous recombination_Homo sapiens_hsa034400.57796239
139Folate biosynthesis_Homo sapiens_hsa007900.57732583
140Salmonella infection_Homo sapiens_hsa051320.56843387
141Inositol phosphate metabolism_Homo sapiens_hsa005620.56505484
142Glycerolipid metabolism_Homo sapiens_hsa005610.55985698
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55191833
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54985301
145Wnt signaling pathway_Homo sapiens_hsa043100.54768750
146Oocyte meiosis_Homo sapiens_hsa041140.54493584
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51166615
148Glycosaminoglycan degradation_Homo sapiens_hsa005310.49793402
149Lysine degradation_Homo sapiens_hsa003100.49622665
150Osteoclast differentiation_Homo sapiens_hsa043800.48621205
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.47251318
152Prolactin signaling pathway_Homo sapiens_hsa049170.47032611
153Galactose metabolism_Homo sapiens_hsa000520.46666984
154mRNA surveillance pathway_Homo sapiens_hsa030150.45611080
155Fat digestion and absorption_Homo sapiens_hsa049750.45608254
156Alzheimers disease_Homo sapiens_hsa050100.44864611
157Chemokine signaling pathway_Homo sapiens_hsa040620.44768786
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44411287
159Legionellosis_Homo sapiens_hsa051340.44372768
160Proteoglycans in cancer_Homo sapiens_hsa052050.43791358
161Melanoma_Homo sapiens_hsa052180.43705184
162Dilated cardiomyopathy_Homo sapiens_hsa054140.43570408
163Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43192729
164Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41351009
165Taste transduction_Homo sapiens_hsa047420.39150470
166Rap1 signaling pathway_Homo sapiens_hsa040150.38779758
167Ras signaling pathway_Homo sapiens_hsa040140.38301782
168Chemical carcinogenesis_Homo sapiens_hsa052040.36908638
169Regulation of autophagy_Homo sapiens_hsa041400.36083685

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