VSIG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.13963641
2L-phenylalanine catabolic process (GO:0006559)7.13963641
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.83865675
4L-phenylalanine metabolic process (GO:0006558)6.83865675
5aromatic amino acid family catabolic process (GO:0009074)6.40538766
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.34627859
7* complement activation, alternative pathway (GO:0006957)6.17556559
8regulation of protein activation cascade (GO:2000257)6.08158367
9regulation of complement activation (GO:0030449)5.82827911
10peptidyl-glutamic acid carboxylation (GO:0017187)5.82715304
11protein carboxylation (GO:0018214)5.82715304
12indole-containing compound catabolic process (GO:0042436)5.73408258
13indolalkylamine catabolic process (GO:0046218)5.73408258
14tryptophan catabolic process (GO:0006569)5.73408258
15regulation of mononuclear cell migration (GO:0071675)5.71991779
16kynurenine metabolic process (GO:0070189)5.62074284
17urea cycle (GO:0000050)5.56558358
18urea metabolic process (GO:0019627)5.56558358
19bile acid biosynthetic process (GO:0006699)5.55914654
20negative regulation of fibrinolysis (GO:0051918)5.55902261
21high-density lipoprotein particle remodeling (GO:0034375)5.51111074
22alpha-linolenic acid metabolic process (GO:0036109)5.44342678
23glyoxylate metabolic process (GO:0046487)5.41033923
24tryptophan metabolic process (GO:0006568)5.40269631
25regulation of fibrinolysis (GO:0051917)5.29791614
26negative regulation of interleukin-12 production (GO:0032695)5.16252589
27nitrogen cycle metabolic process (GO:0071941)5.10320760
28sulfur amino acid catabolic process (GO:0000098)5.04820778
29regulation of cholesterol esterification (GO:0010872)4.99354605
30cysteine metabolic process (GO:0006534)4.92415088
31reverse cholesterol transport (GO:0043691)4.86274534
32glycosphingolipid catabolic process (GO:0046479)4.85187918
33response to peptidoglycan (GO:0032494)4.83990691
34bile acid metabolic process (GO:0008206)4.80115378
35phospholipid efflux (GO:0033700)4.78496297
36opsonization (GO:0008228)4.77385009
37serine family amino acid catabolic process (GO:0009071)4.74486030
38cellular response to thyroid hormone stimulus (GO:0097067)4.74401345
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.72900612
40protein-lipid complex remodeling (GO:0034368)4.72244519
41macromolecular complex remodeling (GO:0034367)4.72244519
42plasma lipoprotein particle remodeling (GO:0034369)4.72244519
43regulation of macrophage chemotaxis (GO:0010758)4.71839692
44regulation of triglyceride catabolic process (GO:0010896)4.65450460
45plasma lipoprotein particle clearance (GO:0034381)4.64989059
46aromatic amino acid family metabolic process (GO:0009072)4.62811223
47neutrophil activation involved in immune response (GO:0002283)4.58412483
48negative regulation of cholesterol transport (GO:0032375)4.54674907
49negative regulation of sterol transport (GO:0032372)4.54674907
50tyrosine metabolic process (GO:0006570)4.54077387
51regulation of apoptotic cell clearance (GO:2000425)4.52806563
52homocysteine metabolic process (GO:0050667)4.49414960
53* complement activation (GO:0006956)4.49252949
54complement activation, classical pathway (GO:0006958)4.45626598
55triglyceride homeostasis (GO:0070328)4.36430660
56acylglycerol homeostasis (GO:0055090)4.36430660
57glycolipid catabolic process (GO:0019377)4.35306550
58alpha-amino acid catabolic process (GO:1901606)4.34589165
59amino-acid betaine metabolic process (GO:0006577)4.31384006
60oligosaccharide catabolic process (GO:0009313)4.30267260
61cholesterol efflux (GO:0033344)4.29151382
62immunoglobulin mediated immune response (GO:0016064)4.26639573
63macrophage activation involved in immune response (GO:0002281)4.24605912
64lysine catabolic process (GO:0006554)4.24445255
65lysine metabolic process (GO:0006553)4.24445255
66amino sugar catabolic process (GO:0046348)4.23773645
67* protein activation cascade (GO:0072376)4.23215271
68bile acid and bile salt transport (GO:0015721)4.19109243
69imidazole-containing compound metabolic process (GO:0052803)4.16580954
70low-density lipoprotein particle remodeling (GO:0034374)4.15956935
71cellular ketone body metabolic process (GO:0046950)4.12258544
72fibrinolysis (GO:0042730)4.11025183
73plasma lipoprotein particle assembly (GO:0034377)4.07662582
74indolalkylamine metabolic process (GO:0006586)4.02772862
75glycine metabolic process (GO:0006544)4.01643664
76cellular amino acid catabolic process (GO:0009063)3.97784239
77glutamate metabolic process (GO:0006536)3.97205504
78cellular glucuronidation (GO:0052695)3.94728387
79lipopolysaccharide-mediated signaling pathway (GO:0031663)3.94464134
80ethanol oxidation (GO:0006069)3.94238620
81cellular biogenic amine catabolic process (GO:0042402)3.93635330
82amine catabolic process (GO:0009310)3.93635330
83positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.93054752
84coenzyme catabolic process (GO:0009109)3.92449530
85regulation of humoral immune response (GO:0002920)3.88846830
86ceramide catabolic process (GO:0046514)3.86152499
87benzene-containing compound metabolic process (GO:0042537)3.84656764
88aldehyde catabolic process (GO:0046185)3.82601992
89arginine metabolic process (GO:0006525)3.82150090
90blood coagulation, intrinsic pathway (GO:0007597)3.80373372
91cellular modified amino acid catabolic process (GO:0042219)3.79476822
92dicarboxylic acid biosynthetic process (GO:0043650)3.77606725
93serine family amino acid metabolic process (GO:0009069)3.76081006
94detection of molecule of bacterial origin (GO:0032490)3.71590269
95response to thyroid hormone (GO:0097066)3.71423859
96drug catabolic process (GO:0042737)3.71156259
97protein-lipid complex assembly (GO:0065005)3.70614856
98acute-phase response (GO:0006953)3.70396462
99phospholipid homeostasis (GO:0055091)3.68924917
100positive regulation of lipid catabolic process (GO:0050996)3.68047267
101positive regulation by symbiont of host defense response (GO:0052509)3.67830658
102modulation by symbiont of host defense response (GO:0052031)3.67830658
103modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67830658
104modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67830658
105positive regulation by organism of defense response of other organism involved in symbiotic interact3.67830658
106modulation by symbiont of host immune response (GO:0052553)3.67830658
107cholesterol homeostasis (GO:0042632)3.67269296
108positive regulation of mast cell activation involved in immune response (GO:0033008)3.67082436
109positive regulation of mast cell degranulation (GO:0043306)3.67082436
110plasma lipoprotein particle organization (GO:0071827)3.64235401
111positive regulation of lipoprotein lipase activity (GO:0051006)3.63727653
112positive regulation of triglyceride lipase activity (GO:0061365)3.63727653
113negative regulation of lipase activity (GO:0060192)3.62346082
114sterol homeostasis (GO:0055092)3.61191408
115monocyte chemotaxis (GO:0002548)3.59700022
116cofactor catabolic process (GO:0051187)3.57970575
117ketone body metabolic process (GO:1902224)3.55037312
118N-acetylneuraminate metabolic process (GO:0006054)3.54989862
119serine family amino acid biosynthetic process (GO:0009070)3.53992547
120eosinophil chemotaxis (GO:0048245)3.53678874
121very-low-density lipoprotein particle assembly (GO:0034379)3.52091112
122regulation of cholesterol storage (GO:0010885)3.51959943
123carboxylic acid catabolic process (GO:0046395)3.51357117
124organic acid catabolic process (GO:0016054)3.51357117
125T-helper 1 type immune response (GO:0042088)3.51182132
126positive regulation of leukocyte degranulation (GO:0043302)3.50647660
127uronic acid metabolic process (GO:0006063)3.50223348
128glucuronate metabolic process (GO:0019585)3.50223348
129lipoprotein metabolic process (GO:0042157)3.46870149
130barbed-end actin filament capping (GO:0051016)3.45797785
131protein-lipid complex subunit organization (GO:0071825)3.45525572
132regulation of mast cell degranulation (GO:0043304)3.41354976
133positive regulation of gamma-delta T cell activation (GO:0046645)3.41288968
134acetyl-CoA metabolic process (GO:0006084)3.40710103
135regulation of hypersensitivity (GO:0002883)3.38859748
136positive regulation of chemokine biosynthetic process (GO:0045080)3.34928172
137positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.33142027
138positive regulation of mast cell activation (GO:0033005)3.32365812
139cellular extravasation (GO:0045123)3.31390156
140regulation of vitamin D biosynthetic process (GO:0060556)3.31017943
141macrophage activation (GO:0042116)3.26930911
142positive regulation of cellular amide metabolic process (GO:0034250)3.26006587
143membrane lipid catabolic process (GO:0046466)3.24674110
144regulation of myeloid leukocyte mediated immunity (GO:0002886)3.24314418
145negative regulation of nitric oxide biosynthetic process (GO:0045019)3.21927783
146positive regulation of monocyte chemotaxis (GO:0090026)3.21236403
147eosinophil migration (GO:0072677)3.21097124
148myeloid dendritic cell differentiation (GO:0043011)3.19840286
149adenosine receptor signaling pathway (GO:0001973)3.16541750
150interferon-gamma-mediated signaling pathway (GO:0060333)3.14338055
151microglial cell activation (GO:0001774)3.13648269
152regulation of mast cell activation involved in immune response (GO:0033006)3.13554296
153apoptotic cell clearance (GO:0043277)3.12264415
154regulation of podosome assembly (GO:0071801)3.11863748
155sphingolipid catabolic process (GO:0030149)3.11020438
156granulocyte activation (GO:0036230)3.10357324
157positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.08922200
158virion attachment to host cell (GO:0019062)3.08083307
159adhesion of symbiont to host cell (GO:0044650)3.08083307
160B cell mediated immunity (GO:0019724)3.07704097
161positive regulation of antigen processing and presentation (GO:0002579)3.07151763
162regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06022992
163regulation of leukocyte degranulation (GO:0043300)3.03959014
164detection of external biotic stimulus (GO:0098581)3.00919887
165negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.99626005
166negative regulation of cytokine production involved in immune response (GO:0002719)2.97190977
167positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97095986
168macrophage differentiation (GO:0030225)2.95231057
169myeloid cell activation involved in immune response (GO:0002275)2.94713107
170histamine secretion (GO:0001821)2.92066591
171regulation of interferon-beta biosynthetic process (GO:0045357)2.91915978
172myeloid dendritic cell activation (GO:0001773)2.90263995
173regulation of antigen processing and presentation (GO:0002577)2.89857265
174positive regulation of heat generation (GO:0031652)2.88509088
175negative regulation of myeloid cell apoptotic process (GO:0033033)2.88259600
176phagocytosis, engulfment (GO:0006911)2.86730982
177regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85334411
178regulation of interferon-alpha production (GO:0032647)2.84461338
179regulation of mast cell activation (GO:0033003)2.84287728
180detection of other organism (GO:0098543)2.84078893
181negative regulation of erythrocyte differentiation (GO:0045647)2.83762126
182positive regulation of cholesterol efflux (GO:0010875)2.83286504
183pinocytosis (GO:0006907)2.82419126
184keratan sulfate catabolic process (GO:0042340)2.82294215
185regulation of chemokine biosynthetic process (GO:0045073)2.81779205
186regulation of cytokine secretion involved in immune response (GO:0002739)2.79835052
187adhesion of symbiont to host (GO:0044406)2.77029555
188negative regulation of granulocyte differentiation (GO:0030853)2.76243355
189phagosome maturation (GO:0090382)2.73531334
190positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73419414
191response to muramyl dipeptide (GO:0032495)2.73402095
192peptide catabolic process (GO:0043171)2.73182917
193cellular response to lipopolysaccharide (GO:0071222)2.72929237
194regulation of inflammatory response to antigenic stimulus (GO:0002861)2.72114897
195positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.71418687
196hydrogen peroxide biosynthetic process (GO:0050665)2.70097579
197neutrophil chemotaxis (GO:0030593)2.68826602
198regulation of fever generation (GO:0031620)2.68117976
199cellular response to molecule of bacterial origin (GO:0071219)2.67753599
200detection of biotic stimulus (GO:0009595)2.67537520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.06468870
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.88192776
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.56150620
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.23024212
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.01080547
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.81036969
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.63510124
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.89413041
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.79552995
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.76262427
11VDR_24787735_ChIP-Seq_THP-1_Human2.47524274
12SPI1_23127762_ChIP-Seq_K562_Human2.34488194
13VDR_24763502_ChIP-Seq_THP-1_Human2.26303943
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21755282
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14745704
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10737006
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10129421
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02510500
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4541797
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98772854
21SPI1_23547873_ChIP-Seq_NB4_Human1.98325144
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93047585
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92981082
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.89248570
25VDR_21846776_ChIP-Seq_THP-1_Human1.87901770
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84242445
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78654548
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76442598
29CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75994333
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71078746
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66158568
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58870302
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.57918664
34PU_27001747_Chip-Seq_BMDM_Mouse1.52777090
35CLOCK_20551151_ChIP-Seq_293T_Human1.50629274
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.49475830
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49071546
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43683530
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43111996
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36026190
41* HTT_18923047_ChIP-ChIP_STHdh_Human1.35890039
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.35666416
43PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35147173
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.33585308
45CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32914766
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31153107
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30426928
48HNF4A_19822575_ChIP-Seq_HepG2_Human1.30393439
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28408775
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.27968844
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27029371
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26555099
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26479027
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26316150
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25589770
56SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25401991
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.25306964
58RUNX_20019798_ChIP-Seq_JUKART_Human1.23547300
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21663597
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19444003
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19175541
62TFEB_21752829_ChIP-Seq_HELA_Human1.18784070
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17219015
64STAT1_20625510_ChIP-Seq_HELA_Human1.12943559
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12474850
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11837103
67GATA1_22025678_ChIP-Seq_K562_Human1.10782822
68MAF_26560356_Chip-Seq_TH1_Human1.09163853
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07224526
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06529052
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04864470
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00808976
73TCF7_22412390_ChIP-Seq_EML_Mouse0.97750333
74ESR1_21235772_ChIP-Seq_MCF-7_Human0.97498193
75KDM2B_26808549_Chip-Seq_DND41_Human0.95073512
76GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94128453
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93412399
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93227895
79SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92651155
80IRF8_21731497_ChIP-ChIP_J774_Mouse0.92475575
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92352969
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91846523
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91503375
84IRF8_27001747_Chip-Seq_BMDM_Mouse0.91163842
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90804930
86* MYB_26560356_Chip-Seq_TH2_Human0.88692189
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88370795
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87368910
89LXR_22292898_ChIP-Seq_THP-1_Human0.85443580
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84593241
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82777384
92BCL6_27268052_Chip-Seq_Bcells_Human0.82101582
93KDM2B_26808549_Chip-Seq_K562_Human0.81645024
94UTX_26944678_Chip-Seq_JUKART_Human0.80215911
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79232199
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78989754
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78060070
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77812832
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74099451
100GATA4_25053715_ChIP-Seq_YYC3_Human0.73692597
101EGR1_19032775_ChIP-ChIP_M12_Human0.73489622
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72397133
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71786818
104RARA_24833708_ChIP-Seq_LIVER_Mouse0.70983910
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.69952601
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69074101
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68869962
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66768767
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66768767
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.65663140
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65181200
112BRD4_27068464_Chip-Seq_AML-cells_Mouse0.65051588
113GATA2_19941826_ChIP-Seq_K562_Human0.64111255
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64049638
115GATA1_19941826_ChIP-Seq_K562_Human0.63917359
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62627026
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.61657643
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.61387788
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61142937
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60507155
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.58883863
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57343368
123RARB_24833708_ChIP-Seq_LIVER_Mouse0.57257106
124CEBPB_22108803_ChIP-Seq_LS180_Human0.55843445
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54395184
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.53458940
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.52841633
128MYC_19915707_ChIP-ChIP_AK7_Human0.51634567
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.51528589
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49869269
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.49253779
132P53_21459846_ChIP-Seq_SAOS-2_Human0.49129010
133SPI1_20517297_ChIP-Seq_HL60_Human0.48526368
134ESET_19884257_ChIP-Seq_ESCs_Mouse0.47448481
135PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.47278692
136MYB_21317192_ChIP-Seq_ERMYB_Mouse0.46276780
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.46161710
138ZNF263_19887448_ChIP-Seq_K562_Human0.45584578
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.45539668
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.45454461
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.44972808
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.43922453
143TAF2_19829295_ChIP-Seq_ESCs_Human0.43725786
144SCL_19346495_ChIP-Seq_HPC-7_Human0.43454120
145BCOR_27268052_Chip-Seq_Bcells_Human0.43366945
146FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43035908
147RACK7_27058665_Chip-Seq_MCF-7_Human0.43029468
148PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42893290
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.42811410
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.42409694
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.41718190
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41591756
153GATA6_25053715_ChIP-Seq_YYC3_Human0.40636345
154PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40514540
155AR_20517297_ChIP-Seq_VCAP_Human0.40384809
156EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39623921
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.39489962
158FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39214769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.82241919
2MP0005360_urolithiasis7.25080786
3MP0005085_abnormal_gallbladder_physiolo6.05120570
4MP0005365_abnormal_bile_salt5.85409058
5MP0008875_abnormal_xenobiotic_pharmacok4.95003301
6MP0009840_abnormal_foam_cell3.84222449
7MP0003806_abnormal_nucleotide_metabolis3.79107251
8MP0003252_abnormal_bile_duct3.61659159
9MP0010329_abnormal_lipoprotein_level3.57161869
10MP0002148_abnormal_hypersensitivity_rea3.18227923
11MP0005083_abnormal_biliary_tract2.98230844
12MP0003172_abnormal_lysosome_physiology2.89328039
13MP0000343_altered_response_to2.79028510
14MP0005332_abnormal_amino_acid2.72088496
15MP0003195_calcinosis2.71532815
16MP0001835_abnormal_antigen_presentation2.63575546
17MP0003191_abnormal_cellular_cholesterol2.56498108
18MP0001666_abnormal_nutrient_absorption2.40779422
19MP0005671_abnormal_response_to2.36915290
20MP0005000_abnormal_immune_tolerance2.34971893
21MP0005167_abnormal_blood-brain_barrier2.18776348
22MP0000609_abnormal_liver_physiology2.16730689
23MP0009278_abnormal_bone_marrow2.13885374
24MP0004019_abnormal_vitamin_homeostasis2.13538442
25MP0002118_abnormal_lipid_homeostasis2.08636996
26MP0002452_abnormal_antigen_presenting2.00046233
27MP0002138_abnormal_hepatobiliary_system1.97754610
28MP0004510_myositis1.97622592
29MP0002998_abnormal_bone_remodeling1.88808340
30MP0002723_abnormal_immune_serum1.85092240
31MP0005319_abnormal_enzyme/_coenzyme1.79714337
32MP0003868_abnormal_feces_composition1.70398498
33MP0001800_abnormal_humoral_immune1.69409265
34MP0001764_abnormal_homeostasis1.62323141
35MP0005397_hematopoietic_system_phenotyp1.61379804
36MP0001545_abnormal_hematopoietic_system1.61379804
37MP0003705_abnormal_hypodermis_morpholog1.60834753
38MP0005584_abnormal_enzyme/coenzyme_acti1.56595342
39MP0002420_abnormal_adaptive_immunity1.53866864
40MP0001819_abnormal_immune_cell1.53804041
41MP0008004_abnormal_stomach_pH1.50759754
42MP0005310_abnormal_salivary_gland1.48554318
43MP0002405_respiratory_system_inflammati1.45533500
44MP0003448_altered_tumor_morphology1.43656446
45MP0005451_abnormal_body_composition1.43536820
46MP0003656_abnormal_erythrocyte_physiolo1.42324223
47MP0000920_abnormal_myelination1.40393611
48MP0003828_pulmonary_edema1.38964793
49MP0000604_amyloidosis1.37658385
50MP0003011_delayed_dark_adaptation1.33469003
51MP0009697_abnormal_copulation1.29556344
52MP0009643_abnormal_urine_homeostasis1.24705225
53MP0000858_altered_metastatic_potential1.23814664
54MP0000598_abnormal_liver_morphology1.23148192
55MP0003453_abnormal_keratinocyte_physiol1.21852546
56MP0010155_abnormal_intestine_physiology1.21786294
57MP0003436_decreased_susceptibility_to1.20209725
58MP0005164_abnormal_response_to1.19819980
59* MP0009763_increased_sensitivity_to1.16296872
60MP0003186_abnormal_redox_activity1.13498608
61MP0009333_abnormal_splenocyte_physiolog1.12661415
62MP0003724_increased_susceptibility_to1.11484543
63MP0010368_abnormal_lymphatic_system1.09481395
64MP0005058_abnormal_lysosome_morphology1.09031022
65MP0006054_spinal_hemorrhage1.08401480
66MP0008469_abnormal_protein_level1.06611592
67MP0009764_decreased_sensitivity_to1.03655029
68MP0008260_abnormal_autophagy1.03435875
69MP0002254_reproductive_system_inflammat1.02474702
70MP0005165_increased_susceptibility_to1.02418048
71MP0005670_abnormal_white_adipose1.00515212
72MP0000716_abnormal_immune_system0.99572240
73MP0005464_abnormal_platelet_physiology0.97305812
74MP0001542_abnormal_bone_strength0.93205187
75MP0003075_altered_response_to0.92752624
76MP0003690_abnormal_glial_cell0.92712365
77MP0009642_abnormal_blood_homeostasis0.92116989
78MP0005647_abnormal_sex_gland0.91740230
79MP0003279_aneurysm0.88444659
80MP0005390_skeleton_phenotype0.88099935
81MP0003634_abnormal_glial_cell0.85478454
82MP0002090_abnormal_vision0.85470441
83MP0005595_abnormal_vascular_smooth0.85150067
84MP0002837_dystrophic_cardiac_calcinosis0.82501063
85MP0003795_abnormal_bone_structure0.81247152
86MP0005408_hypopigmentation0.79241002
87MP0005636_abnormal_mineral_homeostasis0.78917883
88MP0002933_joint_inflammation0.77840265
89MP0002277_abnormal_respiratory_mucosa0.77435000
90MP0003091_abnormal_cell_migration0.77065905
91MP0002971_abnormal_brown_adipose0.77041238
92MP0000689_abnormal_spleen_morphology0.74758456
93MP0009053_abnormal_anal_canal0.73752050
94MP0009765_abnormal_xenobiotic_induced0.73661381
95MP0004130_abnormal_muscle_cell0.73586920
96MP0002078_abnormal_glucose_homeostasis0.72735019
97MP0002429_abnormal_blood_cell0.72484552
98MP0005376_homeostasis/metabolism_phenot0.72192461
99MP0005535_abnormal_body_temperature0.71990373
100MP0003329_amyloid_beta_deposits0.71842018
101MP0003183_abnormal_peptide_metabolism0.70260231
102MP0005220_abnormal_exocrine_pancreas0.70146907
103MP0002877_abnormal_melanocyte_morpholog0.68587731
104MP0005334_abnormal_fat_pad0.68303815
105MP0005257_abnormal_intraocular_pressure0.67873318
106MP0003633_abnormal_nervous_system0.66939605
107MP0002398_abnormal_bone_marrow0.65945094
108MP0000465_gastrointestinal_hemorrhage0.64523677
109MP0003638_abnormal_response/metabolism_0.64453558
110MP0001663_abnormal_digestive_system0.64443962
111MP0002419_abnormal_innate_immunity0.62825528
112MP0004947_skin_inflammation0.62561758
113MP0001756_abnormal_urination0.62518382
114MP0002332_abnormal_exercise_endurance0.62184184
115MP0006036_abnormal_mitochondrial_physio0.61464339
116MP0005084_abnormal_gallbladder_morpholo0.60991974
117MP0000249_abnormal_blood_vessel0.60604810
118MP0001533_abnormal_skeleton_physiology0.60273170
119MP0001851_eye_inflammation0.60210345
120MP0002136_abnormal_kidney_physiology0.59473223
121MP0005448_abnormal_energy_balance0.59383110
122MP0005166_decreased_susceptibility_to0.58104869
123MP0000639_abnormal_adrenal_gland0.58010299
124MP0000371_diluted_coat_color0.57843051
125* MP0005025_abnormal_response_to0.56852912
126MP0000685_abnormal_immune_system0.56661616
127MP0001845_abnormal_inflammatory_respons0.56321325
128MP0002722_abnormal_immune_system0.56190709
129MP0001790_abnormal_immune_system0.56027682
130MP0005387_immune_system_phenotype0.56027682
131MP0005395_other_phenotype0.53151159
132MP0008873_increased_physiological_sensi0.52696049
133MP0008874_decreased_physiological_sensi0.52094259
134MP0002876_abnormal_thyroid_physiology0.51041117
135MP0001661_extended_life_span0.50244509
136MP0006082_CNS_inflammation0.49660180
137MP0002168_other_aberrant_phenotype0.48663693
138MP0005248_abnormal_Harderian_gland0.46094054
139MP0004782_abnormal_surfactant_physiolog0.45453135
140MP0005023_abnormal_wound_healing0.45096010
141MP0005266_abnormal_metabolism0.45043872
142MP0002928_abnormal_bile_duct0.42995486
143MP0001853_heart_inflammation0.41317075
144MP0001915_intracranial_hemorrhage0.39295511
145MP0003303_peritoneal_inflammation0.38350453
146MP0005666_abnormal_adipose_tissue0.38297399
147MP0000230_abnormal_systemic_arterial0.37044765
148MP0004883_abnormal_blood_vessel0.36753507
149MP0003300_gastrointestinal_ulcer0.35914925
150MP0009785_altered_susceptibility_to0.35736678
151MP0002135_abnormal_kidney_morphology0.35356365
152MP0006035_abnormal_mitochondrial_morpho0.35153382
153MP0008438_abnormal_cutaneous_collagen0.35087667
154MP0009115_abnormal_fat_cell0.34999589
155MP0001243_abnormal_dermal_layer0.34008547
156MP0003953_abnormal_hormone_level0.33241823

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)8.24986876
2Abnormality of liposaccharide metabolism (HP:0010968)8.24986876
3Abnormality of glycosphingolipid metabolism (HP:0004343)8.24986876
4Deep venous thrombosis (HP:0002625)7.83721390
5Prolonged partial thromboplastin time (HP:0003645)6.93897908
6Abnormality of aromatic amino acid family metabolism (HP:0004338)6.80268804
7Complement deficiency (HP:0004431)6.78586115
8Intrahepatic cholestasis (HP:0001406)6.62524106
9Abnormality of monocarboxylic acid metabolism (HP:0010996)6.26414152
10Xanthomatosis (HP:0000991)6.04679526
11Hypobetalipoproteinemia (HP:0003563)5.82657380
12Systemic lupus erythematosus (HP:0002725)5.78068892
13Increased cerebral lipofuscin (HP:0011813)5.63480468
14Abnormality of complement system (HP:0005339)5.54816516
15Hyperlipoproteinemia (HP:0010980)5.21588234
16Joint hemorrhage (HP:0005261)5.07794098
17Disinhibition (HP:0000734)5.01783872
18Abnormality of the common coagulation pathway (HP:0010990)4.89647201
19Dysostosis multiplex (HP:0000943)4.80453802
20Abnormality of macrophages (HP:0004311)4.75897666
21Glomerulonephritis (HP:0000099)4.72519366
22Mutism (HP:0002300)4.72092231
23Increased neuronal autofluorescent lipopigment (HP:0002074)4.60051596
24Recurrent bacterial skin infections (HP:0005406)4.44504080
25Hypolipoproteinemia (HP:0010981)4.44363527
26Recurrent abscess formation (HP:0002722)4.43410130
27Loss of speech (HP:0002371)4.40743995
28Hyperammonemia (HP:0001987)4.23316080
29Epidermoid cyst (HP:0200040)4.14897574
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.07885601
31Hypoalphalipoproteinemia (HP:0003233)3.98614643
32Neurofibrillary tangles (HP:0002185)3.94477146
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.93571632
34Eczematoid dermatitis (HP:0000976)3.91279056
35Abnormality of methionine metabolism (HP:0010901)3.90879870
36Ketosis (HP:0001946)3.84108341
37Hyperglycinemia (HP:0002154)3.80333927
38Abnormality of polysaccharide metabolism (HP:0011012)3.76162396
39Abnormality of glycosaminoglycan metabolism (HP:0004371)3.76162396
40Abnormality of mucopolysaccharide metabolism (HP:0011020)3.76162396
41Abnormality of aspartate family amino acid metabolism (HP:0010899)3.74582973
42Abnormality of glutamine family amino acid metabolism (HP:0010902)3.74433534
43Axonal loss (HP:0003447)3.69674620
44Fat malabsorption (HP:0002630)3.66307874
45Abnormality of pyrimidine metabolism (HP:0004353)3.64940136
46Nuclear cataract (HP:0100018)3.60189615
47Urinary glycosaminoglycan excretion (HP:0003541)3.57029991
48Mucopolysacchariduria (HP:0008155)3.57029991
49Hypercholesterolemia (HP:0003124)3.57012585
50Abnormality of the intrinsic pathway (HP:0010989)3.51112610
51Hypoglycemic coma (HP:0001325)3.45516725
52Hyperglycinuria (HP:0003108)3.40290257
53Abnormality of glycine metabolism (HP:0010895)3.38388145
54Abnormality of serine family amino acid metabolism (HP:0010894)3.38388145
55Recurrent gram-negative bacterial infections (HP:0005420)3.38379276
56Spontaneous hematomas (HP:0007420)3.33857750
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.33586615
58Conjugated hyperbilirubinemia (HP:0002908)3.25659364
59Abnormality of the vasculature of the conjunctiva (HP:0008054)3.16622562
60Mediastinal lymphadenopathy (HP:0100721)3.14344747
61Agnosia (HP:0010524)3.11946336
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.09952191
63Autoimmune thrombocytopenia (HP:0001973)3.04660757
64Hyperbilirubinemia (HP:0002904)3.03532507
65Abnormality of fatty-acid metabolism (HP:0004359)3.00991510
66Nephritis (HP:0000123)2.98614017
67Apathy (HP:0000741)2.94074540
68Upper motor neuron abnormality (HP:0002127)2.94031887
69Myocardial infarction (HP:0001658)2.91068792
70Abnormality of nucleobase metabolism (HP:0010932)2.90354141
71Diminished motivation (HP:0000745)2.90104475
72Menorrhagia (HP:0000132)2.88292287
73Inappropriate behavior (HP:0000719)2.85606713
74Delayed CNS myelination (HP:0002188)2.85058263
75Orchitis (HP:0100796)2.84730144
76Purpura (HP:0000979)2.82583561
77Cerebral inclusion bodies (HP:0100314)2.80805083
78Neuronal loss in central nervous system (HP:0002529)2.78046601
79Myositis (HP:0100614)2.76706100
80Spontaneous abortion (HP:0005268)2.75929727
81Steatorrhea (HP:0002570)2.73812627
82Hematochezia (HP:0002573)2.73583149
83Hepatocellular carcinoma (HP:0001402)2.71388258
84Retinal atrophy (HP:0001105)2.70992573
85Ketoacidosis (HP:0001993)2.66055213
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65514878
87Stomatitis (HP:0010280)2.64545391
88Increased serum ferritin (HP:0003281)2.61809353
89Skin nodule (HP:0200036)2.61452290
90Optic neuritis (HP:0100653)2.61367735
91Retrobulbar optic neuritis (HP:0100654)2.61367735
92Abnormality of serum amino acid levels (HP:0003112)2.59861460
93Esophageal varix (HP:0002040)2.59289556
94Mitral stenosis (HP:0001718)2.58769111
95Abnormality of purine metabolism (HP:0004352)2.53061144
96Interstitial pulmonary disease (HP:0006530)2.51740022
97Hypochromic microcytic anemia (HP:0004840)2.49178274
98Gingival bleeding (HP:0000225)2.46128704
99Amyloidosis (HP:0011034)2.45033378
100Vascular calcification (HP:0004934)2.44361440
101Progressive neurologic deterioration (HP:0002344)2.41790584
102Recurrent skin infections (HP:0001581)2.41649722
103Metabolic acidosis (HP:0001942)2.36840950
104Obstructive lung disease (HP:0006536)2.36102634
105Chronic obstructive pulmonary disease (HP:0006510)2.36102634
106Gingivitis (HP:0000230)2.35485018
107Personality changes (HP:0000751)2.34725675
108Metaphyseal irregularity (HP:0003025)2.34650152
109Dementia (HP:0000726)2.30799399
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27695672
111Dicarboxylic aciduria (HP:0003215)2.27695672
112Spastic diplegia (HP:0001264)2.27078368
113Abnormal gallbladder morphology (HP:0012437)2.23764652
114Acanthocytosis (HP:0001927)2.21943489
115Irritability (HP:0000737)2.21910195
116Lethargy (HP:0001254)2.20523700
117Pathologic fracture (HP:0002756)2.20352573
118Hypoglycemic seizures (HP:0002173)2.19083700
119Hepatosplenomegaly (HP:0001433)2.18769791
120Cholelithiasis (HP:0001081)2.18246990
121Cholecystitis (HP:0001082)2.17846614
122Abnormal gallbladder physiology (HP:0012438)2.17846614
123Basal ganglia calcification (HP:0002135)2.16452498
124Thrombophlebitis (HP:0004418)2.15594416
125Cardiovascular calcification (HP:0011915)2.15526597
126Peripheral demyelination (HP:0011096)2.11722924
127Pulmonary infiltrates (HP:0002113)2.09449267
128Asymmetric septal hypertrophy (HP:0001670)2.08768490
129Prolonged neonatal jaundice (HP:0006579)2.08371104
130Conjunctival telangiectasia (HP:0000524)2.07476183
131Neonatal onset (HP:0003623)2.07228316
132Supranuclear gaze palsy (HP:0000605)2.05496121
133Petechiae (HP:0000967)2.04921442
134Gout (HP:0001997)2.04028628
135Abnormality of the periventricular white matter (HP:0002518)2.03844917
136Late onset (HP:0003584)2.00673548
137Hemorrhage of the eye (HP:0011885)1.99708039
138Progressive visual loss (HP:0000529)1.99522762
139Increased CSF protein (HP:0002922)1.97870119
140Sensorimotor neuropathy (HP:0007141)1.97190718
141Cerebral edema (HP:0002181)1.97049153
142Peritonitis (HP:0002586)1.95477839
143Vertebral compression fractures (HP:0002953)1.92513002
144Global brain atrophy (HP:0002283)1.92113989
145Acute hepatic failure (HP:0006554)1.92031529
146Arthropathy (HP:0003040)1.91141360
147Hemoptysis (HP:0002105)1.91114479
148Pancreatitis (HP:0001733)1.90259393
149Abnormality of iron homeostasis (HP:0011031)1.89975287
150Malnutrition (HP:0004395)1.89857622
151Polyneuropathy (HP:0001271)1.89785407
152Cardiomegaly (HP:0001640)1.89232309
153Pulmonary embolism (HP:0002204)1.88801404
154Thoracic kyphosis (HP:0002942)1.88446489
155Memory impairment (HP:0002354)1.87537082
156Bone pain (HP:0002653)1.87477314
157Opisthotonus (HP:0002179)1.84150244
158Vacuolated lymphocytes (HP:0001922)1.84144694
159Vomiting (HP:0002013)1.82353440
160Abnormality of the gallbladder (HP:0005264)1.81433743
161Abnormality of transition element cation homeostasis (HP:0011030)1.81370318
162Recurrent fungal infections (HP:0002841)1.79019348
163Keratoconjunctivitis sicca (HP:0001097)1.78964326
164Brushfield spots (HP:0001088)1.78534799
165Turricephaly (HP:0000262)1.77901265
166Epistaxis (HP:0000421)1.77704292
167Poikilocytosis (HP:0004447)1.76398651
168Enlarged kidneys (HP:0000105)1.75404457
169Premature loss of primary teeth (HP:0006323)1.72390283
170Hyperinsulinemic hypoglycemia (HP:0000825)1.71982182
171Generalized aminoaciduria (HP:0002909)1.70447207
172Urticaria (HP:0001025)1.70342376
173Elevated hepatic transaminases (HP:0002910)1.67235450
174Abnormal cartilage morphology (HP:0002763)1.66681835
175Meningitis (HP:0001287)1.66306887
176Abnormal enzyme/coenzyme activity (HP:0012379)1.65935348
177Nausea (HP:0002018)1.65533686
178Restrictive lung disease (HP:0002091)1.65335566
179Status epilepticus (HP:0002133)1.64692901
180J-shaped sella turcica (HP:0002680)1.64501705
181Rickets (HP:0002748)1.63954928
182Vasculitis (HP:0002633)1.63633296
183Bone cyst (HP:0012062)1.62282385
184Abnormality of the basal ganglia (HP:0002134)1.61633866
185Mucosal telangiectasiae (HP:0100579)1.61585616
186Keratoconjunctivitis (HP:0001096)1.59809995
187Pustule (HP:0200039)1.59076406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.37604874
2BCKDK5.21230041
3ERN14.52747757
4SIK13.53797805
5FGFR43.52600786
6TAOK33.36515090
7NME23.11868170
8GRK73.00216992
9DAPK22.64010114
10PKN22.63416063
11DDR22.56765050
12RIPK42.46648523
13TRIB32.42153962
14INSRR2.40991114
15CAMK1D2.15503451
16MET2.11402459
17MATK2.06723843
18TYK22.04063489
19TAOK21.91268670
20MAP2K41.90184590
21BLK1.78014256
22ERBB41.77723403
23RIPK11.67823251
24ACVR1B1.66610421
25PRPF4B1.66005437
26PTK61.63266729
27CAMKK21.56999511
28MOS1.52635752
29FLT31.48746639
30EPHB11.47646877
31GRK61.46154819
32CAMK1G1.43165293
33CDC42BPA1.40442126
34TAOK11.39852733
35MAPK111.34444589
36TBK11.29851066
37JAK31.28570724
38MAP2K31.25391799
39PIK3CG1.25079530
40PDK21.24185628
41PIM21.23501615
42BMPR21.20353692
43MAP4K11.19395233
44MAP3K71.18502343
45BMX1.15421401
46ADRBK21.15374860
47JAK11.12508922
48TGFBR21.11456074
49MAP3K111.10829988
50JAK21.09804532
51TXK1.08989723
52ABL21.08460168
53KDR1.06888987
54NEK91.00732368
55CSK1.00186225
56MAP3K100.97874736
57PRKAA20.97238761
58MAP3K140.95691258
59MAPK120.91697531
60CHUK0.79307918
61MAPK40.79172511
62TESK10.77884782
63TGFBR10.77786019
64MAP3K50.77496382
65IRAK20.76033430
66EPHA30.75976446
67LATS10.75813029
68MAP3K130.75276932
69CSF1R0.74763879
70ERBB20.74720718
71IRAK10.72290387
72TESK20.70369502
73PDGFRA0.70346651
74IGF1R0.69897645
75MARK30.69599045
76MAP3K30.67957760
77PRKCZ0.67170900
78FGFR20.65352857
79FRK0.64652043
80IKBKE0.62325637
81CAMKK10.62184711
82PRKACG0.61578346
83PAK40.61448066
84PDPK10.61259420
85KIT0.59736278
86PRKCH0.58947819
87EPHB20.58098427
88ZAP700.57091983
89ARAF0.55602788
90SGK30.55311994
91DAPK10.54647533
92PTK20.53254906
93RPS6KC10.53029549
94RPS6KL10.53029549
95GSK3A0.52498070
96CDK60.52182854
97FGFR30.51704643
98ABL10.51446674
99MAPK70.51117263
100RPS6KA20.50831698
101TYRO30.49994479
102MAP3K60.49422464
103EGFR0.49403337
104PINK10.49345706
105DYRK1B0.48668717
106IRAK30.47405094
107ITK0.47067278
108TNK20.46017215
109HCK0.44518143
110CDK40.43044345
111PDGFRB0.42665511
112CAMK40.42593053
113FGFR10.42368266
114RET0.41370210
115RPS6KA60.40867685
116PRKAA10.39661028
117PKN10.39010031
118PDK10.38865319
119MAP2K60.38753436
120PRKCQ0.37822399
121CAMK2G0.35811877
122INSR0.34850363
123STK380.34734555
124EPHA20.34514500
125BTK0.34414039
126PIM10.33859986
127MARK20.33767442
128LATS20.33734048
129DAPK30.33453875
130MAP3K10.32933234
131FES0.32871592
132PRKCD0.30930804
133LIMK10.30813262
134FYN0.30508796
135TIE10.30473401
136SIK20.30223587
137IRAK40.29342008
138PRKG20.27999297
139IKBKB0.27560043
140TEC0.27162384
141FGR0.23316513
142MTOR0.23029591
143LYN0.22674073
144ICK0.22559014
145STK100.22556810
146LCK0.20436310
147SYK0.20071125

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.36785532
2Nitrogen metabolism_Homo sapiens_hsa009103.70730392
3* Complement and coagulation cascades_Homo sapiens_hsa046103.37364038
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34644131
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28260334
6Staphylococcus aureus infection_Homo sapiens_hsa051503.22809224
7Arginine biosynthesis_Homo sapiens_hsa002203.04592520
8Rheumatoid arthritis_Homo sapiens_hsa053232.88421658
9Osteoclast differentiation_Homo sapiens_hsa043802.69358762
10Asthma_Homo sapiens_hsa053102.59622654
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58521861
12Tryptophan metabolism_Homo sapiens_hsa003802.56305885
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45516231
14Fatty acid degradation_Homo sapiens_hsa000712.38338306
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33649953
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32350061
17Allograft rejection_Homo sapiens_hsa053302.28135143
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.27614941
19Tuberculosis_Homo sapiens_hsa051522.24841656
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24170490
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22395066
22Caffeine metabolism_Homo sapiens_hsa002322.18036677
23Phagosome_Homo sapiens_hsa041452.10908488
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02476782
25Graft-versus-host disease_Homo sapiens_hsa053322.01742049
26Peroxisome_Homo sapiens_hsa041461.98551211
27Butanoate metabolism_Homo sapiens_hsa006501.96455112
28Histidine metabolism_Homo sapiens_hsa003401.95062115
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.94795796
30Autoimmune thyroid disease_Homo sapiens_hsa053201.91951011
31Chemical carcinogenesis_Homo sapiens_hsa052041.87281451
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83394375
33PPAR signaling pathway_Homo sapiens_hsa033201.82888569
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81835404
35Propanoate metabolism_Homo sapiens_hsa006401.80129779
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.79955643
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.75783920
38Fatty acid metabolism_Homo sapiens_hsa012121.72853426
39Antigen processing and presentation_Homo sapiens_hsa046121.71497887
40beta-Alanine metabolism_Homo sapiens_hsa004101.67694035
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.66968587
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64918294
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61660088
44Retinol metabolism_Homo sapiens_hsa008301.58216962
45Type I diabetes mellitus_Homo sapiens_hsa049401.56098962
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53927788
47Salmonella infection_Homo sapiens_hsa051321.53063211
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51855564
49TNF signaling pathway_Homo sapiens_hsa046681.51129205
50Phenylalanine metabolism_Homo sapiens_hsa003601.48923521
51Bile secretion_Homo sapiens_hsa049761.45813548
52Selenocompound metabolism_Homo sapiens_hsa004501.44943101
53Collecting duct acid secretion_Homo sapiens_hsa049661.43456471
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40534492
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39846297
56Toxoplasmosis_Homo sapiens_hsa051451.39787628
57Hematopoietic cell lineage_Homo sapiens_hsa046401.35978192
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33517204
59Tyrosine metabolism_Homo sapiens_hsa003501.29815502
60Starch and sucrose metabolism_Homo sapiens_hsa005001.29578063
61ABC transporters_Homo sapiens_hsa020101.27529418
62Pyruvate metabolism_Homo sapiens_hsa006201.24169359
63Fatty acid elongation_Homo sapiens_hsa000621.21473084
64Mineral absorption_Homo sapiens_hsa049781.19392332
65Sulfur metabolism_Homo sapiens_hsa009201.18649262
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17737943
67Influenza A_Homo sapiens_hsa051641.17659920
68Viral myocarditis_Homo sapiens_hsa054161.17545114
69Cysteine and methionine metabolism_Homo sapiens_hsa002701.15760206
70Folate biosynthesis_Homo sapiens_hsa007901.14787213
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11942715
72Biosynthesis of amino acids_Homo sapiens_hsa012301.10616715
73Steroid biosynthesis_Homo sapiens_hsa001001.09880239
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07559760
75Fat digestion and absorption_Homo sapiens_hsa049751.06372298
76B cell receptor signaling pathway_Homo sapiens_hsa046621.02254036
77Carbon metabolism_Homo sapiens_hsa012001.00588177
78Chemokine signaling pathway_Homo sapiens_hsa040620.98861450
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96239050
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96181755
81Sphingolipid metabolism_Homo sapiens_hsa006000.91810923
82Sulfur relay system_Homo sapiens_hsa041220.91780421
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91352928
84Arginine and proline metabolism_Homo sapiens_hsa003300.88839931
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88226292
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87934327
87Lysine degradation_Homo sapiens_hsa003100.86777434
88Vitamin digestion and absorption_Homo sapiens_hsa049770.83540870
89Vibrio cholerae infection_Homo sapiens_hsa051100.82294694
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.81374733
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78938359
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.78183250
93Herpes simplex infection_Homo sapiens_hsa051680.75856039
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72926426
95Shigellosis_Homo sapiens_hsa051310.70329422
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69579091
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.69255370
98Measles_Homo sapiens_hsa051620.68594508
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68357488
100Apoptosis_Homo sapiens_hsa042100.67493959
101Prion diseases_Homo sapiens_hsa050200.64771993
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64007773
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63041150
104Bladder cancer_Homo sapiens_hsa052190.62742044
105Vitamin B6 metabolism_Homo sapiens_hsa007500.62382321
106Other glycan degradation_Homo sapiens_hsa005110.62152712
107One carbon pool by folate_Homo sapiens_hsa006700.59638013
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.58872715
109Glycerolipid metabolism_Homo sapiens_hsa005610.58659294
110Hepatitis B_Homo sapiens_hsa051610.56139117
111Linoleic acid metabolism_Homo sapiens_hsa005910.55043575
112Pentose phosphate pathway_Homo sapiens_hsa000300.54534129
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53927298
114Glutathione metabolism_Homo sapiens_hsa004800.52293752
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.51922425
116Acute myeloid leukemia_Homo sapiens_hsa052210.51754585
117Fatty acid biosynthesis_Homo sapiens_hsa000610.49282210
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.45917519
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43723906
120Synaptic vesicle cycle_Homo sapiens_hsa047210.42551672
121T cell receptor signaling pathway_Homo sapiens_hsa046600.41700016
122Metabolic pathways_Homo sapiens_hsa011000.40434177
123Platelet activation_Homo sapiens_hsa046110.40130840
124HIF-1 signaling pathway_Homo sapiens_hsa040660.39079100
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37005581
126Endocytosis_Homo sapiens_hsa041440.36858190
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36227306
128Prolactin signaling pathway_Homo sapiens_hsa049170.35497726
129VEGF signaling pathway_Homo sapiens_hsa043700.35181522
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32139380
131Pertussis_Homo sapiens_hsa051330.31217375
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30397814
133Primary immunodeficiency_Homo sapiens_hsa053400.29650701
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.29200620
135Epstein-Barr virus infection_Homo sapiens_hsa051690.26952967
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26865750
137Insulin resistance_Homo sapiens_hsa049310.26411613
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.26019926
139Galactose metabolism_Homo sapiens_hsa000520.25668029
140Arachidonic acid metabolism_Homo sapiens_hsa005900.22909028
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.22425957
142Type II diabetes mellitus_Homo sapiens_hsa049300.22292102
143Renal cell carcinoma_Homo sapiens_hsa052110.19733918
144HTLV-I infection_Homo sapiens_hsa051660.19500076
145Notch signaling pathway_Homo sapiens_hsa043300.18534723
146Fructose and mannose metabolism_Homo sapiens_hsa000510.17618999
147GnRH signaling pathway_Homo sapiens_hsa049120.17569276
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13442997
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11410065
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11251191
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11057893
152Pancreatic cancer_Homo sapiens_hsa052120.10725075
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.09142345
154Glucagon signaling pathway_Homo sapiens_hsa049220.06467028
155Lysosome_Homo sapiens_hsa041420.05774266
156Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04871943
157Malaria_Homo sapiens_hsa051440.02606363
158Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1952200
159Renin-angiotensin system_Homo sapiens_hsa04614-0.1730388
160African trypanosomiasis_Homo sapiens_hsa05143-0.1677352
161Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1470291
162Hepatitis C_Homo sapiens_hsa05160-0.1358036
163Leishmaniasis_Homo sapiens_hsa05140-0.1353791
164Legionellosis_Homo sapiens_hsa05134-0.1249347
165Insulin signaling pathway_Homo sapiens_hsa04910-0.1144839
166Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1137356
167Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0976186
168Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0878170
169Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0812732
170Amoebiasis_Homo sapiens_hsa05146-0.0444270
171Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0360307
172AMPK signaling pathway_Homo sapiens_hsa04152-0.0111252

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