VSNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)6.30886946
2glutamate secretion (GO:0014047)6.10516374
3synaptic vesicle docking involved in exocytosis (GO:0016081)6.09421817
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.01896664
5vocalization behavior (GO:0071625)5.94605299
6sodium ion export (GO:0071436)5.93373743
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.53298376
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.51378477
9regulation of synaptic vesicle exocytosis (GO:2000300)5.49672022
10neuron cell-cell adhesion (GO:0007158)5.41504822
11L-amino acid import (GO:0043092)5.40982872
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.29997068
13synaptic vesicle maturation (GO:0016188)5.19978257
14regulation of glutamate receptor signaling pathway (GO:1900449)5.18905638
15locomotory exploration behavior (GO:0035641)5.05024598
16neurotransmitter-gated ion channel clustering (GO:0072578)5.00254642
17neurotransmitter secretion (GO:0007269)4.98049997
18neuronal action potential propagation (GO:0019227)4.89934658
19regulation of synaptic vesicle transport (GO:1902803)4.88912175
20presynaptic membrane assembly (GO:0097105)4.86232364
21protein localization to synapse (GO:0035418)4.80760221
22amino acid import (GO:0043090)4.79516881
23negative regulation of synaptic transmission, GABAergic (GO:0032229)4.73429409
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70594354
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.58467698
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.56000775
27neuron-neuron synaptic transmission (GO:0007270)4.51161968
28presynaptic membrane organization (GO:0097090)4.46167310
29postsynaptic membrane organization (GO:0001941)4.40665811
30synaptic transmission, glutamatergic (GO:0035249)4.37203402
31potassium ion homeostasis (GO:0055075)4.36919759
32glutamate receptor signaling pathway (GO:0007215)4.31858687
33gamma-aminobutyric acid signaling pathway (GO:0007214)4.28738343
34long-term synaptic potentiation (GO:0060291)4.25560332
35axon ensheathment in central nervous system (GO:0032291)4.16464201
36central nervous system myelination (GO:0022010)4.16464201
37startle response (GO:0001964)4.16219282
38potassium ion import (GO:0010107)4.15752042
39exploration behavior (GO:0035640)4.10247675
40cerebellar granule cell differentiation (GO:0021707)4.09385104
41response to histamine (GO:0034776)4.09251696
42positive regulation of synapse maturation (GO:0090129)4.00478421
43gamma-aminobutyric acid transport (GO:0015812)3.98922942
44positive regulation of dendritic spine development (GO:0060999)3.98063413
45neuronal ion channel clustering (GO:0045161)3.97924274
46neurotransmitter transport (GO:0006836)3.96729282
47cell communication by electrical coupling (GO:0010644)3.93401250
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.90490636
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.88620190
50cellular sodium ion homeostasis (GO:0006883)3.84255788
51neuromuscular process controlling balance (GO:0050885)3.84142390
52positive regulation of dendritic spine morphogenesis (GO:0061003)3.82959944
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82161690
54regulation of neuronal synaptic plasticity (GO:0048168)3.81990089
55layer formation in cerebral cortex (GO:0021819)3.79611016
56cerebellar Purkinje cell differentiation (GO:0021702)3.76963718
57regulation of postsynaptic membrane potential (GO:0060078)3.76558969
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.75926896
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.75620896
60regulation of dendritic spine morphogenesis (GO:0061001)3.73362648
61regulation of neurotransmitter levels (GO:0001505)3.72047379
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.67637582
63regulation of synaptic plasticity (GO:0048167)3.64805053
64positive regulation of membrane potential (GO:0045838)3.63486241
65dendritic spine morphogenesis (GO:0060997)3.62545734
66transferrin transport (GO:0033572)3.61532851
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.60829335
68regulation of neurotransmitter secretion (GO:0046928)3.59990206
69energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.57807093
70ATP hydrolysis coupled proton transport (GO:0015991)3.57807093
71regulation of ARF protein signal transduction (GO:0032012)3.56913103
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.53971503
73long-term memory (GO:0007616)3.53924708
74membrane depolarization during action potential (GO:0086010)3.53829925
75acidic amino acid transport (GO:0015800)3.52833395
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.49321096
77negative regulation of dendrite morphogenesis (GO:0050774)3.47834327
78regulation of dendritic spine development (GO:0060998)3.47313836
79proline transport (GO:0015824)3.46390720
80synaptic vesicle endocytosis (GO:0048488)3.39858472
81regulation of synapse structural plasticity (GO:0051823)3.39248315
82positive regulation of neurotransmitter transport (GO:0051590)3.37589728
83trivalent inorganic cation transport (GO:0072512)3.37015572
84ferric iron transport (GO:0015682)3.37015572
85neuromuscular process controlling posture (GO:0050884)3.34288088
86vesicle docking involved in exocytosis (GO:0006904)3.33657562
87positive regulation of synaptic transmission (GO:0050806)3.32831237
88positive regulation of neurotransmitter secretion (GO:0001956)3.32739217
89neuron recognition (GO:0008038)3.32094135
90serotonin metabolic process (GO:0042428)3.31884528
91detection of calcium ion (GO:0005513)3.31846031
92mechanosensory behavior (GO:0007638)3.31468339
93regulation of neurotransmitter transport (GO:0051588)3.31410616
94regulation of synapse maturation (GO:0090128)3.30945370
95positive regulation of synapse assembly (GO:0051965)3.29880399
96cell communication involved in cardiac conduction (GO:0086065)3.29872625
97activation of protein kinase A activity (GO:0034199)3.28528259
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26624412
99behavioral fear response (GO:0001662)3.25536534
100behavioral defense response (GO:0002209)3.25536534
101synaptic transmission (GO:0007268)3.20493293
102regulation of glutamate secretion (GO:0014048)3.20197747
103vesicle docking (GO:0048278)3.18117085
104regulation of synaptic transmission (GO:0050804)3.17676715
105auditory behavior (GO:0031223)3.16894601
106behavioral response to cocaine (GO:0048148)3.15514440
107G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15244420
108neuromuscular synaptic transmission (GO:0007274)3.15108374
109dicarboxylic acid transport (GO:0006835)3.14184734
110regulation of exocytosis (GO:0017157)3.13621950
111membrane depolarization (GO:0051899)3.13448175
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13171526
113regulation of vesicle fusion (GO:0031338)3.11923333
114L-glutamate transport (GO:0015813)3.11217114
115regulation of synaptic transmission, GABAergic (GO:0032228)3.10719713
116fear response (GO:0042596)3.10569293
117positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10352622
118regulation of voltage-gated calcium channel activity (GO:1901385)3.10089638
119establishment of synaptic vesicle localization (GO:0097480)3.09522514
120synaptic vesicle transport (GO:0048489)3.09522514
121neuromuscular process (GO:0050905)3.08730852
122signal release (GO:0023061)3.08612340
123regulation of female receptivity (GO:0045924)3.06126750
124learning (GO:0007612)3.05992431
125transmission of nerve impulse (GO:0019226)3.03080379
126cellular response to ammonium ion (GO:0071242)3.02833449
127cellular potassium ion homeostasis (GO:0030007)3.02189943
128neurotransmitter uptake (GO:0001504)3.02124527
129membrane hyperpolarization (GO:0060081)3.01198250
130synapse assembly (GO:0007416)3.00595701
131negative regulation of amino acid transport (GO:0051956)2.99676254
132female mating behavior (GO:0060180)2.97181237
133negative regulation of dendrite development (GO:2000171)2.95758319
134long term synaptic depression (GO:0060292)2.94114352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97359543
2GBX2_23144817_ChIP-Seq_PC3_Human4.64785435
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14503300
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05667138
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90281218
6TAF15_26573619_Chip-Seq_HEK293_Human2.84016089
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72802972
8REST_21632747_ChIP-Seq_MESCs_Mouse2.67627906
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59697347
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51129770
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51129770
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45008689
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39921225
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37179900
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.36410889
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33842467
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31399087
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30356265
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.27873721
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.25231036
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.23949482
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23098041
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20999086
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13255142
25DROSHA_22980978_ChIP-Seq_HELA_Human2.11282839
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09374525
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08808948
28SMAD4_21799915_ChIP-Seq_A2780_Human1.99286804
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96995079
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.93625642
31* EZH2_27294783_Chip-Seq_ESCs_Mouse1.89303342
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87263556
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84498865
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84206720
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83981545
36P300_19829295_ChIP-Seq_ESCs_Human1.83964868
37AR_21572438_ChIP-Seq_LNCaP_Human1.76992363
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67993881
39* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60364687
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59609572
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.58265467
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56421757
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56342379
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53024044
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.52221576
46FUS_26573619_Chip-Seq_HEK293_Human1.49673846
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48366621
48AR_25329375_ChIP-Seq_VCAP_Human1.47183719
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.46020714
50* SOX2_21211035_ChIP-Seq_LN229_Gbm1.45455546
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44253742
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42569531
53RNF2_27304074_Chip-Seq_NSC_Mouse1.39027472
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.38266538
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35877169
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34874623
57STAT3_23295773_ChIP-Seq_U87_Human1.33793886
58TET1_21490601_ChIP-Seq_MESCs_Mouse1.30354991
59* KDM2B_26808549_Chip-Seq_K562_Human1.28609675
60ZNF274_21170338_ChIP-Seq_K562_Hela1.28292262
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27647455
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27366952
63VDR_22108803_ChIP-Seq_LS180_Human1.26886560
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.26851713
65ER_23166858_ChIP-Seq_MCF-7_Human1.26606765
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26416683
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26259237
68IGF1R_20145208_ChIP-Seq_DFB_Human1.25158970
69TCF4_23295773_ChIP-Seq_U87_Human1.25123595
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.22697519
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20336948
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19694935
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18994592
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.18187975
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17500013
76AR_19668381_ChIP-Seq_PC3_Human1.16191032
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16039917
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15583173
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13280221
80RUNX2_22187159_ChIP-Seq_PCA_Human1.10350370
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10051215
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09991312
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09901504
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.09626560
85JUN_21703547_ChIP-Seq_K562_Human1.07941098
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.07768897
87AHR_22903824_ChIP-Seq_MCF-7_Human1.06870477
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06336116
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05486698
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03700799
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02806847
92CTCF_27219007_Chip-Seq_Bcells_Human1.02806152
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.02602246
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02597009
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01809138
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01674576
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.01243871
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99493319
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98165116
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98165116
101SOX9_26525672_Chip-Seq_HEART_Mouse0.97084051
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96712540
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96363058
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95794681
105DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95191365
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94983403
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94868144
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94794324
109RXR_22108803_ChIP-Seq_LS180_Human0.94562332
110* DPY_21335234_ChIP-Seq_ESCs_Mouse0.94236100
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94179405
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94079420
113TP53_18474530_ChIP-ChIP_U2OS_Human0.93603045
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93320780
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92282065
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.91991174
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.91903918
118KDM2B_26808549_Chip-Seq_REH_Human0.91324085
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90908005
120TP53_16413492_ChIP-PET_HCT116_Human0.90471276
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88702277
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86144703
123OCT4_19829295_ChIP-Seq_ESCs_Human0.82890781
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82670626
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81251735
126EGR1_19032775_ChIP-ChIP_M12_Human0.79859783
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78895816
128* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77442301
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.75592162
130RUNX1_26923725_Chip-Seq_HPCs_Mouse0.73989578
131KLF4_19829295_ChIP-Seq_ESCs_Human0.72305289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.79302927
2MP0003880_abnormal_central_pattern5.42446716
3MP0003635_abnormal_synaptic_transmissio4.13238082
4MP0009046_muscle_twitch3.73597703
5MP0009745_abnormal_behavioral_response3.63543069
6MP0002064_seizures3.53546713
7MP0004270_analgesia3.34761443
8MP0002063_abnormal_learning/memory/cond3.34467679
9MP0001968_abnormal_touch/_nociception3.24679421
10MP0002572_abnormal_emotion/affect_behav3.02521933
11MP0002272_abnormal_nervous_system2.77190250
12MP0002736_abnormal_nociception_after2.74677691
13MP0001501_abnormal_sleep_pattern2.63636676
14MP0002734_abnormal_mechanical_nocicepti2.59505589
15MP0002822_catalepsy2.58813321
16MP0001486_abnormal_startle_reflex2.47726155
17MP0003787_abnormal_imprinting2.42286841
18MP0009780_abnormal_chondrocyte_physiolo2.37399531
19MP0005646_abnormal_pituitary_gland2.36694705
20MP0002067_abnormal_sensory_capabilities2.19140853
21MP0002735_abnormal_chemical_nociception2.18716625
22MP0001440_abnormal_grooming_behavior2.12290371
23MP0003122_maternal_imprinting2.10306388
24MP0005423_abnormal_somatic_nervous2.06510282
25MP0003879_abnormal_hair_cell2.01597224
26MP0001970_abnormal_pain_threshold1.88057792
27MP0002733_abnormal_thermal_nociception1.85526000
28MP0006276_abnormal_autonomic_nervous1.85425926
29MP0004924_abnormal_behavior1.79577000
30MP0005386_behavior/neurological_phenoty1.79577000
31MP0008569_lethality_at_weaning1.79388217
32MP0001188_hyperpigmentation1.74445565
33MP0002557_abnormal_social/conspecific_i1.74038456
34MP0002184_abnormal_innervation1.65229870
35MP0001984_abnormal_olfaction1.63732143
36MP0000920_abnormal_myelination1.62373296
37MP0004142_abnormal_muscle_tone1.57392463
38MP0004811_abnormal_neuron_physiology1.56259771
39MP0001529_abnormal_vocalization1.52622799
40MP0002909_abnormal_adrenal_gland1.52320100
41MP0001905_abnormal_dopamine_level1.50481137
42MP0002837_dystrophic_cardiac_calcinosis1.42129470
43MP0002066_abnormal_motor_capabilities/c1.41255682
44MP0002876_abnormal_thyroid_physiology1.40323522
45MP0000778_abnormal_nervous_system1.39991656
46MP0003329_amyloid_beta_deposits1.29982711
47MP0003633_abnormal_nervous_system1.27325744
48MP0002882_abnormal_neuron_morphology1.25512530
49MP0000955_abnormal_spinal_cord1.23648641
50MP0004147_increased_porphyrin_level1.23572615
51MP0005645_abnormal_hypothalamus_physiol1.18945370
52MP0001502_abnormal_circadian_rhythm1.12608793
53MP0008877_abnormal_DNA_methylation1.10752269
54MP0003631_nervous_system_phenotype1.08355456
55MP0008872_abnormal_physiological_respon1.04000857
56MP0003183_abnormal_peptide_metabolism1.03520346
57MP0000013_abnormal_adipose_tissue1.02306566
58MP0004858_abnormal_nervous_system1.02133069
59MP0008874_decreased_physiological_sensi1.01360333
60MP0000751_myopathy0.99847208
61MP0004885_abnormal_endolymph0.98605162
62MP0005171_absent_coat_pigmentation0.98031126
63MP0002152_abnormal_brain_morphology0.94829535
64MP0010386_abnormal_urinary_bladder0.94024224
65MP0001963_abnormal_hearing_physiology0.92651134
66MP0002069_abnormal_eating/drinking_beha0.91607263
67MP0004215_abnormal_myocardial_fiber0.87655549
68MP0001346_abnormal_lacrimal_gland0.87632995
69MP0003646_muscle_fatigue0.87406521
70MP0004085_abnormal_heartbeat0.87362871
71MP0002229_neurodegeneration0.86343356
72MP0003123_paternal_imprinting0.85335135
73MP0003075_altered_response_to0.85103787
74MP0005535_abnormal_body_temperature0.84970823
75MP0004484_altered_response_of0.84924245
76MP0004742_abnormal_vestibular_system0.83935273
77MP0001664_abnormal_digestion0.83449264
78MP0005551_abnormal_eye_electrophysiolog0.83192868
79MP0003121_genomic_imprinting0.83009986
80MP0001986_abnormal_taste_sensitivity0.81201356
81MP0004145_abnormal_muscle_electrophysio0.79216823
82MP0004233_abnormal_muscle_weight0.79126728
83MP0005167_abnormal_blood-brain_barrier0.75886776
84MP0000579_abnormal_nail_morphology0.75052134
85MP0001348_abnormal_lacrimal_gland0.75011004
86MP0005394_taste/olfaction_phenotype0.69079649
87MP0005499_abnormal_olfactory_system0.69079649
88MP0003632_abnormal_nervous_system0.68949192
89MP0004043_abnormal_pH_regulation0.68516687
90MP0002638_abnormal_pupillary_reflex0.67684807
91MP0005623_abnormal_meninges_morphology0.66969197
92MP0001177_atelectasis0.65841766
93MP0000631_abnormal_neuroendocrine_gland0.64349436
94MP0002752_abnormal_somatic_nervous0.60904148
95MP0001943_abnormal_respiration0.59595400
96MP0003137_abnormal_impulse_conducting0.57556668
97MP0002090_abnormal_vision0.56921744
98MP0002082_postnatal_lethality0.55745339
99MP0010770_preweaning_lethality0.55745339
100MP0008004_abnormal_stomach_pH0.54280813
101MP0010769_abnormal_survival0.53064033
102MP0003634_abnormal_glial_cell0.52927609
103MP0003690_abnormal_glial_cell0.52369404
104MP0001485_abnormal_pinna_reflex0.51759011
105MP0000604_amyloidosis0.51323468
106MP0001299_abnormal_eye_distance/0.50411690
107MP0010768_mortality/aging0.49993217
108MP0000569_abnormal_digit_pigmentation0.49451353
109MP0000026_abnormal_inner_ear0.49426959
110MP0003956_abnormal_body_size0.49310661
111MP0003172_abnormal_lysosome_physiology0.49025758
112MP0008260_abnormal_autophagy0.48263003
113MP0002653_abnormal_ependyma_morphology0.46349251
114MP0003861_abnormal_nervous_system0.46143752
115MP0002873_normal_phenotype0.45220418
116MP0004130_abnormal_muscle_cell0.44338416
117MP0002169_no_abnormal_phenotype0.43554952
118MP0000639_abnormal_adrenal_gland0.40340193
119MP0001731_abnormal_postnatal_growth0.39491861
120MP0003938_abnormal_ear_development0.38204709

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.08179329
2Atonic seizures (HP:0010819)6.38159045
3Epileptic encephalopathy (HP:0200134)6.35232095
4Focal seizures (HP:0007359)6.09307536
5Hyperventilation (HP:0002883)5.75341232
6Febrile seizures (HP:0002373)5.57124643
7Myokymia (HP:0002411)5.25513815
8Absence seizures (HP:0002121)4.98047614
9Dialeptic seizures (HP:0011146)4.65102580
10Progressive cerebellar ataxia (HP:0002073)4.43746083
11Visual hallucinations (HP:0002367)4.43217264
12Generalized tonic-clonic seizures (HP:0002069)4.14389600
13Broad-based gait (HP:0002136)4.00270430
14Cerebral hypomyelination (HP:0006808)3.87496331
15Neurofibrillary tangles (HP:0002185)3.77027639
16Papilledema (HP:0001085)3.76288126
17Gaze-evoked nystagmus (HP:0000640)3.70259991
18Pheochromocytoma (HP:0002666)3.39561293
19Annular pancreas (HP:0001734)3.38230599
20Tetraplegia (HP:0002445)3.36205598
21Impaired vibration sensation in the lower limbs (HP:0002166)3.33238277
22Poor eye contact (HP:0000817)3.30391458
23Delusions (HP:0000746)3.25246567
24Intention tremor (HP:0002080)3.18864093
25Abnormal eating behavior (HP:0100738)3.12128536
26Obstructive sleep apnea (HP:0002870)3.12028483
27Impaired social interactions (HP:0000735)3.07940032
28Abnormal social behavior (HP:0012433)3.07940032
29Neuroendocrine neoplasm (HP:0100634)3.06059681
30Cerebral inclusion bodies (HP:0100314)3.03932136
31Abnormal hair whorl (HP:0010721)3.01949191
32Dysmetric saccades (HP:0000641)2.99873873
33Truncal ataxia (HP:0002078)2.99744472
34Dysdiadochokinesis (HP:0002075)2.99067170
35Epileptiform EEG discharges (HP:0011182)2.92778406
36Drooling (HP:0002307)2.88375222
37Excessive salivation (HP:0003781)2.88375222
38Protruding tongue (HP:0010808)2.84488568
39Neuronal loss in central nervous system (HP:0002529)2.83966819
40Amblyopia (HP:0000646)2.82514575
41Depression (HP:0000716)2.79908837
42Polyphagia (HP:0002591)2.78322608
43Lower limb muscle weakness (HP:0007340)2.76914521
44Progressive inability to walk (HP:0002505)2.74347383
45Anxiety (HP:0000739)2.73828477
46Akinesia (HP:0002304)2.73683592
47Dysmetria (HP:0001310)2.70325419
48Limb dystonia (HP:0002451)2.69181577
49Action tremor (HP:0002345)2.68259549
50Postural instability (HP:0002172)2.66176984
51Inability to walk (HP:0002540)2.64130342
52Clonus (HP:0002169)2.64004721
53Absent speech (HP:0001344)2.63873720
54Failure to thrive in infancy (HP:0001531)2.60718477
55EEG with generalized epileptiform discharges (HP:0011198)2.59441662
56Blue irides (HP:0000635)2.58129008
57Impaired smooth pursuit (HP:0007772)2.55914217
58Poor suck (HP:0002033)2.54065206
59Status epilepticus (HP:0002133)2.52716347
60Peripheral hypomyelination (HP:0007182)2.52335862
61Abnormality of binocular vision (HP:0011514)2.51292559
62Diplopia (HP:0000651)2.51292559
63Scanning speech (HP:0002168)2.51067335
64Urinary bladder sphincter dysfunction (HP:0002839)2.50342638
65Hyperthyroidism (HP:0000836)2.48618733
66Gait imbalance (HP:0002141)2.48078209
67Genetic anticipation (HP:0003743)2.45183429
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.44202649
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.44202649
70Hypsarrhythmia (HP:0002521)2.44099353
71CNS hypomyelination (HP:0003429)2.41532002
72Choreoathetosis (HP:0001266)2.41120565
73Impaired vibratory sensation (HP:0002495)2.39571569
74Apathy (HP:0000741)2.38115857
75Bradykinesia (HP:0002067)2.35926767
76Fetal akinesia sequence (HP:0001989)2.35621424
77Oligomenorrhea (HP:0000876)2.34123585
78Rigidity (HP:0002063)2.33045833
79Abnormality of the labia minora (HP:0012880)2.31638767
80Abnormality of ocular smooth pursuit (HP:0000617)2.28200791
81Spastic tetraparesis (HP:0001285)2.28114806
82Congenital primary aphakia (HP:0007707)2.26971935
83Ankle clonus (HP:0011448)2.26485910
84Supranuclear gaze palsy (HP:0000605)2.22367661
85Medial flaring of the eyebrow (HP:0010747)2.21191262
86Insomnia (HP:0100785)2.19274220
87Specific learning disability (HP:0001328)2.18197356
88Generalized myoclonic seizures (HP:0002123)2.17588938
89Gait ataxia (HP:0002066)2.16463420
90Abnormality of the lower motor neuron (HP:0002366)2.16303244
91Resting tremor (HP:0002322)2.15127132
92Nephrogenic diabetes insipidus (HP:0009806)2.14025061
93Focal dystonia (HP:0004373)2.13689346
94Torticollis (HP:0000473)2.13105655
95Morphological abnormality of the pyramidal tract (HP:0002062)2.11873149
96Diminished motivation (HP:0000745)2.10519344
97Ventricular fibrillation (HP:0001663)2.08925793
98Abnormal mitochondria in muscle tissue (HP:0008316)2.06886524
99Termporal pattern (HP:0011008)2.05636187
100Insidious onset (HP:0003587)2.05636187
101Urinary urgency (HP:0000012)2.05496176
102Narrow nasal bridge (HP:0000446)2.04564955
103Neoplasm of the peripheral nervous system (HP:0100007)2.04492861
104Incomplete penetrance (HP:0003829)2.03993333
105Increased circulating renin level (HP:0000848)2.00489648
106Stereotypic behavior (HP:0000733)1.98456838
107Bundle branch block (HP:0011710)1.98422461
108Hypoventilation (HP:0002791)1.97623874
109Rapidly progressive (HP:0003678)1.95629462
110Acute necrotizing encephalopathy (HP:0006965)1.93669967
111Memory impairment (HP:0002354)1.93652945
112Spastic gait (HP:0002064)1.93428498
113Abnormality of salivation (HP:0100755)1.93391982
114Abnormality of saccadic eye movements (HP:0000570)1.89967287
115Lower limb asymmetry (HP:0100559)1.89808501
116Generalized hypopigmentation of hair (HP:0011358)1.89428990
117Hemiplegia (HP:0002301)1.89283526
118Hemiparesis (HP:0001269)1.87238978
119Fair hair (HP:0002286)1.86894047
120Split foot (HP:0001839)1.86747387
121Postural tremor (HP:0002174)1.85897900
122Sleep apnea (HP:0010535)1.85118123
123Progressive macrocephaly (HP:0004481)1.84028062
124Psychosis (HP:0000709)1.83905981
125Craniofacial dystonia (HP:0012179)1.83845832
126Esotropia (HP:0000565)1.83167871
127Sensory axonal neuropathy (HP:0003390)1.82937177
128Thickened helices (HP:0000391)1.82892319
129Mutism (HP:0002300)1.81073479
130Agitation (HP:0000713)1.78954587
131Unsteady gait (HP:0002317)1.78619905
132Abnormality of the corticospinal tract (HP:0002492)1.77161521
133Spastic tetraplegia (HP:0002510)1.71732825
134Heart block (HP:0012722)1.70232317
135Amyotrophic lateral sclerosis (HP:0007354)1.68019710
136Megalencephaly (HP:0001355)1.68002574
137Spinal canal stenosis (HP:0003416)1.67185174
138Agnosia (HP:0010524)1.66428812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.69350384
2NTRK34.23510729
3MAP3K123.66260715
4MAP3K43.49996822
5MAP2K73.40643195
6CDK193.17209300
7EPHA43.07363482
8MAP3K92.58140990
9DAPK22.48854776
10AKT32.32886080
11MAP2K42.32285222
12PLK22.22735784
13DAPK12.20236440
14MINK12.13595650
15CCNB11.94753139
16OXSR11.73344134
17PRPF4B1.71318555
18RIPK41.63566382
19PAK61.53639723
20MARK11.53125795
21NTRK21.45880295
22GRK51.45536698
23TSSK61.44561040
24PRKCG1.41011779
25SIK31.32542715
26CAMKK21.32154973
27CAMKK11.26829105
28CDK51.26449969
29SGK21.19203726
30ALK1.17106391
31CAMK2A1.14948927
32KSR11.14286146
33RIPK11.13220846
34MAPK131.09957008
35SGK4941.08754462
36SGK2231.08754462
37PNCK1.06145600
38TNIK1.01786718
39PDK40.99999325
40PDK30.99999325
41ARAF0.97247312
42KSR20.94947642
43CAMK2B0.93347889
44BRSK10.90162106
45CDK180.89980194
46SGK30.86746257
47UHMK10.85430292
48BRAF0.83188844
49STK380.82736405
50CDK150.82481603
51BMPR20.82180448
52CDK140.80401970
53FES0.79184713
54NME10.78995166
55NTRK10.78881680
56PTK2B0.77422954
57CAMK10.76281754
58PRKCE0.70909838
59CDK11A0.69920955
60MARK20.67138407
61MAPK100.66350276
62WNK30.63312000
63PRKD30.63230907
64STK110.61785067
65TNK20.61727433
66ADRBK20.61685768
67SIK20.60945031
68PDK10.60844088
69SGK10.60814956
70MAP3K110.59674737
71PRKCH0.59122042
72LIMK10.58906418
73PDK20.58714400
74BCR0.58522038
75WNK10.58116187
76PINK10.57828099
77NEK10.57822285
78CAMK2G0.57602489
79DAPK30.57124456
80PKN10.56023139
81FGFR20.54618768
82MUSK0.52502646
83CAMK2D0.51136528
84PDPK10.50292753
85MAP3K20.49145969
86CSNK1G20.48252759
87LATS20.45359284
88DYRK1A0.45178531
89MAP3K130.45057455
90PRKCZ0.44595443
91MYLK0.43260753
92ROCK20.41474356
93RET0.41181207
94ADRBK10.40744647
95FER0.40640302
96FYN0.38506427
97MAPK70.38032944
98PRKCA0.37437866
99RPS6KA30.37401214
100CAMK40.37194535
101MAP3K10.37075897
102PAK30.37017562
103MAPKAPK50.36692415
104TYRO30.35351918
105MAPK120.34769313
106RAF10.34715635
107CDK30.34160169
108MAP2K10.34159084
109TAOK10.32456087
110PHKG20.32323815
111PHKG10.32323815
112CSNK1E0.31691606
113NEK60.31217435
114ERBB40.30672380
115PRKCB0.30628062
116FGR0.29920006
117PLK30.29770527
118TESK10.27643194
119PRKG10.26009591
120PRKG20.24858490
121CSNK1D0.23929769
122PRKACA0.23872115
123CSNK1A10.23222277

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.30610333
2Synaptic vesicle cycle_Homo sapiens_hsa047214.27281205
3Collecting duct acid secretion_Homo sapiens_hsa049663.10100774
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87485788
5GABAergic synapse_Homo sapiens_hsa047272.72477773
6Long-term potentiation_Homo sapiens_hsa047202.65548354
7Amphetamine addiction_Homo sapiens_hsa050312.58393267
8Olfactory transduction_Homo sapiens_hsa047402.58231527
9Circadian entrainment_Homo sapiens_hsa047132.58030370
10Morphine addiction_Homo sapiens_hsa050322.58008711
11Glutamatergic synapse_Homo sapiens_hsa047242.43746836
12Dopaminergic synapse_Homo sapiens_hsa047282.11290961
13Salivary secretion_Homo sapiens_hsa049702.08684421
14Insulin secretion_Homo sapiens_hsa049111.93839693
15Vitamin B6 metabolism_Homo sapiens_hsa007501.92411815
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86855901
17Vibrio cholerae infection_Homo sapiens_hsa051101.86136429
18Taste transduction_Homo sapiens_hsa047421.85377756
19Long-term depression_Homo sapiens_hsa047301.81654391
20Serotonergic synapse_Homo sapiens_hsa047261.75877601
21Gastric acid secretion_Homo sapiens_hsa049711.69024871
22Cholinergic synapse_Homo sapiens_hsa047251.62125714
23Renin secretion_Homo sapiens_hsa049241.62073861
24Calcium signaling pathway_Homo sapiens_hsa040201.56255103
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53967866
26Cocaine addiction_Homo sapiens_hsa050301.52254138
27Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48453372
28Oxytocin signaling pathway_Homo sapiens_hsa049211.44049912
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36480403
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36420399
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35788981
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32679821
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31984753
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28155299
35Oxidative phosphorylation_Homo sapiens_hsa001901.27215444
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21771389
37Gap junction_Homo sapiens_hsa045401.12202813
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11725376
39GnRH signaling pathway_Homo sapiens_hsa049121.10738300
40cAMP signaling pathway_Homo sapiens_hsa040241.09546614
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05477228
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02868023
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00563323
44Cardiac muscle contraction_Homo sapiens_hsa042600.95911385
45Type II diabetes mellitus_Homo sapiens_hsa049300.92822798
46ErbB signaling pathway_Homo sapiens_hsa040120.91951175
47Estrogen signaling pathway_Homo sapiens_hsa049150.89438209
48Glioma_Homo sapiens_hsa052140.88499839
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87128392
50Rheumatoid arthritis_Homo sapiens_hsa053230.85823656
51Bile secretion_Homo sapiens_hsa049760.85314067
52Alzheimers disease_Homo sapiens_hsa050100.83651560
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.80893000
54Phototransduction_Homo sapiens_hsa047440.80784389
55Axon guidance_Homo sapiens_hsa043600.77891482
56Melanogenesis_Homo sapiens_hsa049160.77766717
57Parkinsons disease_Homo sapiens_hsa050120.73567741
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72876234
59Type I diabetes mellitus_Homo sapiens_hsa049400.72327254
60Oocyte meiosis_Homo sapiens_hsa041140.69208063
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68782951
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66130164
63Arginine biosynthesis_Homo sapiens_hsa002200.64399001
64Pancreatic secretion_Homo sapiens_hsa049720.62321748
65MAPK signaling pathway_Homo sapiens_hsa040100.61778526
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61464962
67Arginine and proline metabolism_Homo sapiens_hsa003300.61396258
68Prion diseases_Homo sapiens_hsa050200.60756561
69Dilated cardiomyopathy_Homo sapiens_hsa054140.59963575
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58925452
71Phagosome_Homo sapiens_hsa041450.58236888
72Thyroid hormone synthesis_Homo sapiens_hsa049180.57853499
73Glucagon signaling pathway_Homo sapiens_hsa049220.55466407
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52456859
75Ras signaling pathway_Homo sapiens_hsa040140.50733231
76Histidine metabolism_Homo sapiens_hsa003400.48371976
77Inositol phosphate metabolism_Homo sapiens_hsa005620.47413372
78Huntingtons disease_Homo sapiens_hsa050160.44042758
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43540701
80Circadian rhythm_Homo sapiens_hsa047100.42646095
81Dorso-ventral axis formation_Homo sapiens_hsa043200.42564525
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.41738092
83Alcoholism_Homo sapiens_hsa050340.41111273
84Choline metabolism in cancer_Homo sapiens_hsa052310.41060318
85Pyruvate metabolism_Homo sapiens_hsa006200.39488752
86Mineral absorption_Homo sapiens_hsa049780.39310513
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39202367
88Fatty acid biosynthesis_Homo sapiens_hsa000610.37724209
89Rap1 signaling pathway_Homo sapiens_hsa040150.36841763
90African trypanosomiasis_Homo sapiens_hsa051430.35610621
91beta-Alanine metabolism_Homo sapiens_hsa004100.35605797
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31356005
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.31355975
94Insulin signaling pathway_Homo sapiens_hsa049100.28198552
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28037365
96Ovarian steroidogenesis_Homo sapiens_hsa049130.27338250
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27333813
98mTOR signaling pathway_Homo sapiens_hsa041500.27263325
99Butanoate metabolism_Homo sapiens_hsa006500.25837652
100Melanoma_Homo sapiens_hsa052180.25726627
101Tight junction_Homo sapiens_hsa045300.25049035
102Endocytosis_Homo sapiens_hsa041440.24919224
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24058438
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22283705
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21835671
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21742281
107Wnt signaling pathway_Homo sapiens_hsa043100.21597499
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.20244453
109VEGF signaling pathway_Homo sapiens_hsa043700.19365038
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19016706
111Regulation of autophagy_Homo sapiens_hsa041400.18806268
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18585319
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18033982
114HIF-1 signaling pathway_Homo sapiens_hsa040660.16671435
115Hippo signaling pathway_Homo sapiens_hsa043900.13898269
116AMPK signaling pathway_Homo sapiens_hsa041520.11799618

Most similar genes based on co-expression Upload to Enrichr

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