

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | vocalization behavior (GO:0071625) | 6.60282697 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.02638689 |
| 3 | neuron cell-cell adhesion (GO:0007158) | 5.90644428 |
| 4 | synaptic vesicle exocytosis (GO:0016079) | 5.82942187 |
| 5 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 5.56073221 |
| 6 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.39183604 |
| 7 | locomotory exploration behavior (GO:0035641) | 5.37404703 |
| 8 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.30918406 |
| 9 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.22163980 |
| 10 | protein localization to synapse (GO:0035418) | 5.00370857 |
| 11 | neurotransmitter secretion (GO:0007269) | 4.88898675 |
| 12 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.87297962 |
| 13 | glutamate secretion (GO:0014047) | 4.82152548 |
| 14 | startle response (GO:0001964) | 4.79268601 |
| 15 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.75837323 |
| 16 | neuronal action potential propagation (GO:0019227) | 4.67945193 |
| 17 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.67680909 |
| 18 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.64016723 |
| 19 | exploration behavior (GO:0035640) | 4.63954274 |
| 20 | gamma-aminobutyric acid transport (GO:0015812) | 4.60883778 |
| 21 | synaptic vesicle maturation (GO:0016188) | 4.56864750 |
| 22 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.49284808 |
| 23 | neuron-neuron synaptic transmission (GO:0007270) | 4.44027469 |
| 24 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.25541788 |
| 25 | positive regulation of synapse maturation (GO:0090129) | 4.24760213 |
| 26 | establishment of mitochondrion localization (GO:0051654) | 4.22352544 |
| 27 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.21083660 |
| 28 | presynaptic membrane assembly (GO:0097105) | 4.20677351 |
| 29 | synaptic transmission, glutamatergic (GO:0035249) | 4.18327950 |
| 30 | nucleobase catabolic process (GO:0046113) | 4.15385074 |
| 31 | regulation of synaptic vesicle transport (GO:1902803) | 4.11571025 |
| 32 | glutamate receptor signaling pathway (GO:0007215) | 4.09894431 |
| 33 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.04465795 |
| 34 | long-term synaptic potentiation (GO:0060291) | 4.00145336 |
| 35 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.99216031 |
| 36 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.97339683 |
| 37 | neurotransmitter transport (GO:0006836) | 3.91599204 |
| 38 | postsynaptic membrane organization (GO:0001941) | 3.90438170 |
| 39 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.86307059 |
| 40 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.85549071 |
| 41 | neuron recognition (GO:0008038) | 3.84583927 |
| 42 | long-term memory (GO:0007616) | 3.81992839 |
| 43 | presynaptic membrane organization (GO:0097090) | 3.78552764 |
| 44 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.77646746 |
| 45 | glycosphingolipid biosynthetic process (GO:0006688) | 3.75766489 |
| 46 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.75068538 |
| 47 | response to histamine (GO:0034776) | 3.73224580 |
| 48 | proline transport (GO:0015824) | 3.69806570 |
| 49 | cell migration in hindbrain (GO:0021535) | 3.67963832 |
| 50 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.66229715 |
| 51 | regulation of neurotransmitter levels (GO:0001505) | 3.61848552 |
| 52 | positive regulation of membrane potential (GO:0045838) | 3.61156491 |
| 53 | amino acid import (GO:0043090) | 3.60886435 |
| 54 | C4-dicarboxylate transport (GO:0015740) | 3.59404623 |
| 55 | positive regulation of synapse assembly (GO:0051965) | 3.59295638 |
| 56 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.57476838 |
| 57 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.57476838 |
| 58 | regulation of synapse maturation (GO:0090128) | 3.56738110 |
| 59 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.54807014 |
| 60 | regulation of synapse structural plasticity (GO:0051823) | 3.50471508 |
| 61 | regulation of postsynaptic membrane potential (GO:0060078) | 3.49064795 |
| 62 | transferrin transport (GO:0033572) | 3.48836707 |
| 63 | regulation of synaptic transmission, GABAergic (GO:0032228) | 3.45637682 |
| 64 | transmission of nerve impulse (GO:0019226) | 3.38893827 |
| 65 | synapse assembly (GO:0007416) | 3.38183837 |
| 66 | regulation of synaptic plasticity (GO:0048167) | 3.37912051 |
| 67 | striatum development (GO:0021756) | 3.36159030 |
| 68 | layer formation in cerebral cortex (GO:0021819) | 3.35880913 |
| 69 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.31822123 |
| 70 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.31211891 |
| 71 | succinate metabolic process (GO:0006105) | 3.30102861 |
| 72 | regulation of female receptivity (GO:0045924) | 3.29548709 |
| 73 | cellular potassium ion homeostasis (GO:0030007) | 3.28879099 |
| 74 | behavioral defense response (GO:0002209) | 3.26881627 |
| 75 | behavioral fear response (GO:0001662) | 3.26881627 |
| 76 | ferric iron transport (GO:0015682) | 3.25024341 |
| 77 | trivalent inorganic cation transport (GO:0072512) | 3.25024341 |
| 78 | female mating behavior (GO:0060180) | 3.24839987 |
| 79 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.21887605 |
| 80 | acidic amino acid transport (GO:0015800) | 3.21488844 |
| 81 | positive regulation of vesicle fusion (GO:0031340) | 3.21484896 |
| 82 | sodium ion export (GO:0071436) | 3.19216273 |
| 83 | positive regulation of synaptic transmission (GO:0050806) | 3.18349925 |
| 84 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.16000212 |
| 85 | membrane depolarization during action potential (GO:0086010) | 3.15930059 |
| 86 | synaptic transmission (GO:0007268) | 3.15207504 |
| 87 | response to dietary excess (GO:0002021) | 3.14821557 |
| 88 | learning (GO:0007612) | 3.14805460 |
| 89 | activation of protein kinase A activity (GO:0034199) | 3.13991990 |
| 90 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.13794551 |
| 91 | intraspecies interaction between organisms (GO:0051703) | 3.13168117 |
| 92 | social behavior (GO:0035176) | 3.13168117 |
| 93 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.12570712 |
| 94 | protein insertion into membrane (GO:0051205) | 3.12200682 |
| 95 | regulation of neurotransmitter secretion (GO:0046928) | 3.11502207 |
| 96 | synaptic vesicle endocytosis (GO:0048488) | 3.10755572 |
| 97 | detection of calcium ion (GO:0005513) | 3.10257461 |
| 98 | membrane hyperpolarization (GO:0060081) | 3.10025491 |
| 99 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.09179113 |
| 100 | cerebellar granule cell differentiation (GO:0021707) | 3.08548234 |
| 101 | response to cocaine (GO:0042220) | 3.05981509 |
| 102 | neuromuscular process controlling posture (GO:0050884) | 3.05646475 |
| 103 | regulation of penile erection (GO:0060405) | 3.05553790 |
| 104 | behavioral response to cocaine (GO:0048148) | 3.05361220 |
| 105 | axonal fasciculation (GO:0007413) | 3.05165485 |
| 106 | mitochondrial fragmentation involved in apoptotic process (GO:0043653) | 3.05100837 |
| 107 | regulation of feeding behavior (GO:0060259) | 3.05084246 |
| 108 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.04421491 |
| 109 | fear response (GO:0042596) | 3.03774814 |
| 110 | membrane depolarization (GO:0051899) | 3.03399437 |
| 111 | regulation of synaptic transmission (GO:0050804) | 3.03093458 |
| 112 | neuromuscular synaptic transmission (GO:0007274) | 3.02633232 |
| 113 | regulation of synapse assembly (GO:0051963) | 3.01951557 |
| 114 | neurofilament cytoskeleton organization (GO:0060052) | 3.01121281 |
| 115 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.00600902 |
| 116 | regulation of glutamate secretion (GO:0014048) | 3.00590651 |
| 117 | dendritic spine morphogenesis (GO:0060997) | 3.00542558 |
| 118 | cellular response to ammonium ion (GO:0071242) | 3.00348937 |
| 119 | serotonin metabolic process (GO:0042428) | 2.99018977 |
| 120 | dendrite morphogenesis (GO:0048813) | 2.98545035 |
| 121 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.97547086 |
| 122 | neuronal ion channel clustering (GO:0045161) | 2.97197860 |
| 123 | regulation of vesicle fusion (GO:0031338) | 2.96583985 |
| 124 | synapse organization (GO:0050808) | 2.94902108 |
| 125 | regulation of neurotransmitter transport (GO:0051588) | 2.94256290 |
| 126 | L-amino acid import (GO:0043092) | 2.93645210 |
| 127 | establishment of synaptic vesicle localization (GO:0097480) | 2.93535253 |
| 128 | synaptic vesicle transport (GO:0048489) | 2.93535253 |
| 129 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.92514636 |
| 130 | auditory behavior (GO:0031223) | 2.91170616 |
| 131 | retinal cone cell development (GO:0046549) | 2.89646177 |
| 132 | hippocampus development (GO:0021766) | 2.88397905 |
| 133 | signal release (GO:0023061) | 2.87136165 |
| 134 | primary amino compound metabolic process (GO:1901160) | 2.86571400 |
| 135 | regulation of protein kinase A signaling (GO:0010738) | 2.86088069 |
| 136 | glycine transport (GO:0015816) | 2.83656512 |
| 137 | establishment of vesicle localization (GO:0051650) | 2.81875158 |
| 138 | regulation of dendritic spine development (GO:0060998) | 2.74208427 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.03496669 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.35504597 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.19664303 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.07535495 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.04857362 |
| 6 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.92675132 |
| 7 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.67614051 |
| 8 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.63416798 |
| 9 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.51888566 |
| 10 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.51449339 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.49946006 |
| 12 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.49946006 |
| 13 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.49593930 |
| 14 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.48818848 |
| 15 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.48582629 |
| 16 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.39583343 |
| 17 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.35536492 |
| 18 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.34173397 |
| 19 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.32732238 |
| 20 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.31497721 |
| 21 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.24499333 |
| 22 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.22217384 |
| 23 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.18976595 |
| 24 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.16446762 |
| 25 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.08028059 |
| 26 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.07468324 |
| 27 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.04827357 |
| 28 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.01892697 |
| 29 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.00486859 |
| 30 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.99578643 |
| 31 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.98431974 |
| 32 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.91516054 |
| 33 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.88357575 |
| 34 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.87098690 |
| 35 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.79476298 |
| 36 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.78750503 |
| 37 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.71287309 |
| 38 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.69238781 |
| 39 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.68060977 |
| 40 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.63696674 |
| 41 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.62986795 |
| 42 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.58998986 |
| 43 | * FUS_26573619_Chip-Seq_HEK293_Human | 1.57550309 |
| 44 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.53122739 |
| 45 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.52711739 |
| 46 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.52297939 |
| 47 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.51091549 |
| 48 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.48315442 |
| 49 | AR_25329375_ChIP-Seq_VCAP_Human | 1.47812253 |
| 50 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.47410717 |
| 51 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.46173804 |
| 52 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.45158081 |
| 53 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.44302832 |
| 54 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.44163647 |
| 55 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.42684004 |
| 56 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.41005474 |
| 57 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.40077046 |
| 58 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.35397574 |
| 59 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.35175992 |
| 60 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.34683645 |
| 61 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.30527775 |
| 62 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.28193461 |
| 63 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.24941007 |
| 64 | VDR_22108803_ChIP-Seq_LS180_Human | 1.24919446 |
| 65 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.23721909 |
| 66 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.22796837 |
| 67 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.21921636 |
| 68 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.20974405 |
| 69 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.20546215 |
| 70 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.18581216 |
| 71 | TCF4_23295773_ChIP-Seq_U87_Human | 1.17636675 |
| 72 | JUN_21703547_ChIP-Seq_K562_Human | 1.15722142 |
| 73 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.15527057 |
| 74 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.13288513 |
| 75 | * ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.12948901 |
| 76 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.12787076 |
| 77 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.12052998 |
| 78 | AR_19668381_ChIP-Seq_PC3_Human | 1.10277975 |
| 79 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.07082368 |
| 80 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.06955785 |
| 81 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.06923509 |
| 82 | * AHR_22903824_ChIP-Seq_MCF-7_Human | 1.04255655 |
| 83 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.04144023 |
| 84 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.02552687 |
| 85 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.02507459 |
| 86 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.01671019 |
| 87 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.01444768 |
| 88 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.00785103 |
| 89 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.99974033 |
| 90 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.98658376 |
| 91 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.98041666 |
| 92 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.97906118 |
| 93 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.97711814 |
| 94 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.97410477 |
| 95 | EWS_26573619_Chip-Seq_HEK293_Human | 0.97309972 |
| 96 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.97068379 |
| 97 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.96795457 |
| 98 | KDM2B_26808549_Chip-Seq_REH_Human | 0.95703053 |
| 99 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.95593210 |
| 100 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.95140296 |
| 101 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.94041060 |
| 102 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.94041060 |
| 103 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93954006 |
| 104 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93348592 |
| 105 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.93348592 |
| 106 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.93218458 |
| 107 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93105651 |
| 108 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.91367596 |
| 109 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.90318148 |
| 110 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.89957066 |
| 111 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.89651489 |
| 112 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.89639605 |
| 113 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.89501135 |
| 114 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.88403325 |
| 115 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.88128361 |
| 116 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.87526638 |
| 117 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 0.87260847 |
| 118 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.85444891 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.39867248 |
| 2 | MP0003880_abnormal_central_pattern | 5.06065485 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.07470397 |
| 4 | MP0002822_catalepsy | 4.01495693 |
| 5 | MP0009745_abnormal_behavioral_response | 3.67150149 |
| 6 | MP0009046_muscle_twitch | 3.61845837 |
| 7 | MP0002064_seizures | 3.51360936 |
| 8 | MP0002063_abnormal_learning/memory/cond | 3.31588799 |
| 9 | MP0002572_abnormal_emotion/affect_behav | 3.00536723 |
| 10 | MP0004270_analgesia | 2.89381562 |
| 11 | MP0001968_abnormal_touch/_nociception | 2.86947248 |
| 12 | MP0002272_abnormal_nervous_system | 2.73187412 |
| 13 | MP0001486_abnormal_startle_reflex | 2.59949393 |
| 14 | MP0002735_abnormal_chemical_nociception | 2.58032489 |
| 15 | MP0001501_abnormal_sleep_pattern | 2.55667617 |
| 16 | MP0005423_abnormal_somatic_nervous | 2.54033969 |
| 17 | MP0002734_abnormal_mechanical_nocicepti | 2.45797334 |
| 18 | MP0002736_abnormal_nociception_after | 2.36130847 |
| 19 | MP0005646_abnormal_pituitary_gland | 2.17476497 |
| 20 | MP0006276_abnormal_autonomic_nervous | 2.16177182 |
| 21 | MP0001440_abnormal_grooming_behavior | 2.15128021 |
| 22 | MP0009780_abnormal_chondrocyte_physiolo | 2.10362463 |
| 23 | MP0002067_abnormal_sensory_capabilities | 2.09269548 |
| 24 | MP0003787_abnormal_imprinting | 1.94137492 |
| 25 | MP0002733_abnormal_thermal_nociception | 1.92744018 |
| 26 | MP0001970_abnormal_pain_threshold | 1.90469395 |
| 27 | MP0003122_maternal_imprinting | 1.87491786 |
| 28 | MP0001529_abnormal_vocalization | 1.82056212 |
| 29 | MP0002557_abnormal_social/conspecific_i | 1.80021960 |
| 30 | MP0002184_abnormal_innervation | 1.79182505 |
| 31 | MP0005386_behavior/neurological_phenoty | 1.78911256 |
| 32 | MP0004924_abnormal_behavior | 1.78911256 |
| 33 | MP0004142_abnormal_muscle_tone | 1.78284890 |
| 34 | MP0003329_amyloid_beta_deposits | 1.76434821 |
| 35 | MP0002837_dystrophic_cardiac_calcinosis | 1.76194618 |
| 36 | MP0003879_abnormal_hair_cell | 1.72109084 |
| 37 | MP0008569_lethality_at_weaning | 1.65352199 |
| 38 | MP0001984_abnormal_olfaction | 1.62247105 |
| 39 | MP0000778_abnormal_nervous_system | 1.56395153 |
| 40 | MP0004811_abnormal_neuron_physiology | 1.49845825 |
| 41 | MP0002066_abnormal_motor_capabilities/c | 1.41776720 |
| 42 | MP0001905_abnormal_dopamine_level | 1.41103680 |
| 43 | MP0002876_abnormal_thyroid_physiology | 1.41042353 |
| 44 | MP0005645_abnormal_hypothalamus_physiol | 1.39129703 |
| 45 | MP0000955_abnormal_spinal_cord | 1.35069347 |
| 46 | MP0001188_hyperpigmentation | 1.34299384 |
| 47 | MP0002909_abnormal_adrenal_gland | 1.32661117 |
| 48 | MP0002882_abnormal_neuron_morphology | 1.32642778 |
| 49 | MP0002102_abnormal_ear_morphology | 1.24455862 |
| 50 | MP0000013_abnormal_adipose_tissue | 1.17611644 |
| 51 | MP0000751_myopathy | 1.12857632 |
| 52 | MP0004858_abnormal_nervous_system | 1.08986135 |
| 53 | MP0004885_abnormal_endolymph | 1.08603764 |
| 54 | MP0003938_abnormal_ear_development | 1.05892204 |
| 55 | MP0001502_abnormal_circadian_rhythm | 1.05123326 |
| 56 | MP0005551_abnormal_eye_electrophysiolog | 1.04402423 |
| 57 | MP0002152_abnormal_brain_morphology | 1.01066212 |
| 58 | MP0010386_abnormal_urinary_bladder | 1.01009334 |
| 59 | MP0003633_abnormal_nervous_system | 0.97232313 |
| 60 | MP0008872_abnormal_physiological_respon | 0.96147299 |
| 61 | MP0003631_nervous_system_phenotype | 0.95527621 |
| 62 | MP0002069_abnormal_eating/drinking_beha | 0.95155920 |
| 63 | MP0001963_abnormal_hearing_physiology | 0.94932491 |
| 64 | MP0004085_abnormal_heartbeat | 0.93790267 |
| 65 | MP0004215_abnormal_myocardial_fiber | 0.90902450 |
| 66 | MP0001177_atelectasis | 0.90382372 |
| 67 | MP0002229_neurodegeneration | 0.88539859 |
| 68 | MP0000049_abnormal_middle_ear | 0.87301887 |
| 69 | MP0004147_increased_porphyrin_level | 0.86534377 |
| 70 | MP0005187_abnormal_penis_morphology | 0.86386096 |
| 71 | MP0008789_abnormal_olfactory_epithelium | 0.86095681 |
| 72 | MP0004742_abnormal_vestibular_system | 0.84364362 |
| 73 | MP0003632_abnormal_nervous_system | 0.83238696 |
| 74 | MP0000604_amyloidosis | 0.83216236 |
| 75 | MP0004484_altered_response_of | 0.82494747 |
| 76 | MP0008877_abnormal_DNA_methylation | 0.79732204 |
| 77 | MP0005535_abnormal_body_temperature | 0.78820298 |
| 78 | MP0008874_decreased_physiological_sensi | 0.78631772 |
| 79 | MP0002234_abnormal_pharynx_morphology | 0.77545114 |
| 80 | MP0001270_distended_abdomen | 0.76249637 |
| 81 | MP0000631_abnormal_neuroendocrine_gland | 0.75703168 |
| 82 | MP0002751_abnormal_autonomic_nervous | 0.75256013 |
| 83 | MP0002752_abnormal_somatic_nervous | 0.74840533 |
| 84 | MP0003646_muscle_fatigue | 0.74242037 |
| 85 | MP0001986_abnormal_taste_sensitivity | 0.73628563 |
| 86 | MP0003121_genomic_imprinting | 0.72928329 |
| 87 | MP0003123_paternal_imprinting | 0.71669890 |
| 88 | MP0001664_abnormal_digestion | 0.71099781 |
| 89 | MP0005499_abnormal_olfactory_system | 0.70833917 |
| 90 | MP0005394_taste/olfaction_phenotype | 0.70833917 |
| 91 | MP0003634_abnormal_glial_cell | 0.69502411 |
| 92 | MP0002332_abnormal_exercise_endurance | 0.69206524 |
| 93 | MP0005084_abnormal_gallbladder_morpholo | 0.68621026 |
| 94 | MP0002090_abnormal_vision | 0.67617396 |
| 95 | MP0003221_abnormal_cardiomyocyte_apopto | 0.64825502 |
| 96 | MP0000639_abnormal_adrenal_gland | 0.63832705 |
| 97 | MP0002653_abnormal_ependyma_morphology | 0.63666639 |
| 98 | MP0003861_abnormal_nervous_system | 0.62237297 |
| 99 | MP0003137_abnormal_impulse_conducting | 0.61647944 |
| 100 | MP0001943_abnormal_respiration | 0.61388856 |
| 101 | MP0000026_abnormal_inner_ear | 0.59657858 |
| 102 | MP0003119_abnormal_digestive_system | 0.59219017 |
| 103 | MP0004133_heterotaxia | 0.59006014 |
| 104 | MP0000920_abnormal_myelination | 0.58759940 |
| 105 | MP0002638_abnormal_pupillary_reflex | 0.57379134 |
| 106 | MP0001485_abnormal_pinna_reflex | 0.56508725 |
| 107 | MP0005171_absent_coat_pigmentation | 0.56004474 |
| 108 | MP0004233_abnormal_muscle_weight | 0.55096672 |
| 109 | MP0005623_abnormal_meninges_morphology | 0.54709846 |
| 110 | MP0003690_abnormal_glial_cell | 0.54309706 |
| 111 | MP0002082_postnatal_lethality | 0.53568685 |
| 112 | MP0010770_preweaning_lethality | 0.53568685 |
| 113 | MP0006035_abnormal_mitochondrial_morpho | 0.52327333 |
| 114 | MP0005448_abnormal_energy_balance | 0.51307728 |
| 115 | MP0010769_abnormal_survival | 0.50691621 |
| 116 | MP0004043_abnormal_pH_regulation | 0.50401038 |
| 117 | MP0003956_abnormal_body_size | 0.48758748 |
| 118 | MP0010768_mortality/aging | 0.47341622 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 8.79750380 |
| 2 | Atonic seizures (HP:0010819) | 6.21653563 |
| 3 | Focal seizures (HP:0007359) | 5.69744659 |
| 4 | Febrile seizures (HP:0002373) | 5.51626227 |
| 5 | Epileptic encephalopathy (HP:0200134) | 5.38823361 |
| 6 | Myokymia (HP:0002411) | 5.25308429 |
| 7 | Hyperventilation (HP:0002883) | 5.18924076 |
| 8 | Absence seizures (HP:0002121) | 4.84577481 |
| 9 | Visual hallucinations (HP:0002367) | 4.81280444 |
| 10 | Dialeptic seizures (HP:0011146) | 4.42121188 |
| 11 | Generalized tonic-clonic seizures (HP:0002069) | 4.10808496 |
| 12 | Progressive cerebellar ataxia (HP:0002073) | 4.10352181 |
| 13 | Progressive inability to walk (HP:0002505) | 4.06484106 |
| 14 | Split foot (HP:0001839) | 3.97017452 |
| 15 | Broad-based gait (HP:0002136) | 3.58191134 |
| 16 | Lissencephaly (HP:0001339) | 3.24815398 |
| 17 | Polyphagia (HP:0002591) | 3.20925297 |
| 18 | Impaired social interactions (HP:0000735) | 3.10347649 |
| 19 | Abnormal social behavior (HP:0012433) | 3.10347649 |
| 20 | Abnormal eating behavior (HP:0100738) | 3.06225723 |
| 21 | Gaze-evoked nystagmus (HP:0000640) | 3.04566842 |
| 22 | Inability to walk (HP:0002540) | 3.02904851 |
| 23 | Abnormal hair whorl (HP:0010721) | 3.00369007 |
| 24 | Dysdiadochokinesis (HP:0002075) | 2.96414800 |
| 25 | Poor eye contact (HP:0000817) | 2.95994434 |
| 26 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.94366976 |
| 27 | Gait imbalance (HP:0002141) | 2.92444355 |
| 28 | Drooling (HP:0002307) | 2.89747572 |
| 29 | Excessive salivation (HP:0003781) | 2.89747572 |
| 30 | Abnormality of binocular vision (HP:0011514) | 2.81346297 |
| 31 | Diplopia (HP:0000651) | 2.81346297 |
| 32 | Acute necrotizing encephalopathy (HP:0006965) | 2.79875436 |
| 33 | Truncal ataxia (HP:0002078) | 2.79861696 |
| 34 | Lower limb muscle weakness (HP:0007340) | 2.74842501 |
| 35 | Clonus (HP:0002169) | 2.74661998 |
| 36 | Amblyopia (HP:0000646) | 2.73203347 |
| 37 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.72315773 |
| 38 | Pheochromocytoma (HP:0002666) | 2.71861677 |
| 39 | Epileptiform EEG discharges (HP:0011182) | 2.70209825 |
| 40 | Anxiety (HP:0000739) | 2.68975082 |
| 41 | Limb dystonia (HP:0002451) | 2.67278652 |
| 42 | Retinal dysplasia (HP:0007973) | 2.66870942 |
| 43 | Absent speech (HP:0001344) | 2.66841131 |
| 44 | Poor suck (HP:0002033) | 2.64905717 |
| 45 | Depression (HP:0000716) | 2.61063257 |
| 46 | Progressive macrocephaly (HP:0004481) | 2.59458648 |
| 47 | Neuroendocrine neoplasm (HP:0100634) | 2.59337379 |
| 48 | Congenital primary aphakia (HP:0007707) | 2.57929277 |
| 49 | EEG with generalized epileptiform discharges (HP:0011198) | 2.57396639 |
| 50 | Amyotrophic lateral sclerosis (HP:0007354) | 2.55178693 |
| 51 | Failure to thrive in infancy (HP:0001531) | 2.53677320 |
| 52 | Medial flaring of the eyebrow (HP:0010747) | 2.47122969 |
| 53 | Delusions (HP:0000746) | 2.46800239 |
| 54 | Hypsarrhythmia (HP:0002521) | 2.46417511 |
| 55 | Action tremor (HP:0002345) | 2.45876493 |
| 56 | Peripheral hypomyelination (HP:0007182) | 2.45257713 |
| 57 | Thyroid-stimulating hormone excess (HP:0002925) | 2.43363073 |
| 58 | Dysmetria (HP:0001310) | 2.42762782 |
| 59 | Mutism (HP:0002300) | 2.42708874 |
| 60 | Nephrogenic diabetes insipidus (HP:0009806) | 2.40247828 |
| 61 | Postural instability (HP:0002172) | 2.37855617 |
| 62 | Status epilepticus (HP:0002133) | 2.37713129 |
| 63 | Resting tremor (HP:0002322) | 2.37651751 |
| 64 | Protruding tongue (HP:0010808) | 2.37006486 |
| 65 | Scanning speech (HP:0002168) | 2.36579541 |
| 66 | Fetal akinesia sequence (HP:0001989) | 2.36229353 |
| 67 | Supranuclear gaze palsy (HP:0000605) | 2.35143708 |
| 68 | Ankle clonus (HP:0011448) | 2.35072283 |
| 69 | Ulnar claw (HP:0001178) | 2.34400811 |
| 70 | Hyperthyroidism (HP:0000836) | 2.34105283 |
| 71 | Cerebral hypomyelination (HP:0006808) | 2.30691019 |
| 72 | Bradykinesia (HP:0002067) | 2.28672512 |
| 73 | Specific learning disability (HP:0001328) | 2.28659791 |
| 74 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.28520565 |
| 75 | Cortical dysplasia (HP:0002539) | 2.25980970 |
| 76 | Blue irides (HP:0000635) | 2.25761069 |
| 77 | Pachygyria (HP:0001302) | 2.24686857 |
| 78 | Intention tremor (HP:0002080) | 2.22610430 |
| 79 | Generalized myoclonic seizures (HP:0002123) | 2.22340077 |
| 80 | Abnormality of the labia minora (HP:0012880) | 2.20209788 |
| 81 | Esotropia (HP:0000565) | 2.17662959 |
| 82 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.16855184 |
| 83 | Hypoplasia of the brainstem (HP:0002365) | 2.16855184 |
| 84 | Oligomenorrhea (HP:0000876) | 2.14726777 |
| 85 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.13518658 |
| 86 | Type II lissencephaly (HP:0007260) | 2.12705598 |
| 87 | Agitation (HP:0000713) | 2.12427616 |
| 88 | Hypoplasia of the corpus callosum (HP:0002079) | 2.11889032 |
| 89 | Hemiparesis (HP:0001269) | 2.11420030 |
| 90 | CNS hypomyelination (HP:0003429) | 2.10775864 |
| 91 | Acute encephalopathy (HP:0006846) | 2.07954077 |
| 92 | Cerebral inclusion bodies (HP:0100314) | 2.07784960 |
| 93 | Genetic anticipation (HP:0003743) | 2.06615672 |
| 94 | Narrow nasal bridge (HP:0000446) | 2.05867336 |
| 95 | Abnormality of the corticospinal tract (HP:0002492) | 2.04573024 |
| 96 | Mitochondrial inheritance (HP:0001427) | 2.02898875 |
| 97 | Muscular hypotonia of the trunk (HP:0008936) | 2.02864442 |
| 98 | Akinesia (HP:0002304) | 2.00302407 |
| 99 | Vaginal atresia (HP:0000148) | 2.00171896 |
| 100 | Genital tract atresia (HP:0001827) | 1.99690171 |
| 101 | Urinary urgency (HP:0000012) | 1.99129633 |
| 102 | Paraplegia (HP:0010550) | 1.97672722 |
| 103 | Neuronal loss in central nervous system (HP:0002529) | 1.96914790 |
| 104 | Spastic gait (HP:0002064) | 1.96376106 |
| 105 | Humeroradial synostosis (HP:0003041) | 1.95708315 |
| 106 | Synostosis involving the elbow (HP:0003938) | 1.95708315 |
| 107 | Gait ataxia (HP:0002066) | 1.95550433 |
| 108 | Hemiplegia (HP:0002301) | 1.95399160 |
| 109 | Intellectual disability, severe (HP:0010864) | 1.94660077 |
| 110 | Focal dystonia (HP:0004373) | 1.92872944 |
| 111 | Abnormality of salivation (HP:0100755) | 1.91876000 |
| 112 | Impaired vibratory sensation (HP:0002495) | 1.91334348 |
| 113 | Torticollis (HP:0000473) | 1.91322163 |
| 114 | Sleep apnea (HP:0010535) | 1.91017232 |
| 115 | Generalized hypotonia (HP:0001290) | 1.90130506 |
| 116 | Stereotypic behavior (HP:0000733) | 1.89181321 |
| 117 | Hypoventilation (HP:0002791) | 1.87889334 |
| 118 | Impaired smooth pursuit (HP:0007772) | 1.87830677 |
| 119 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.87314999 |
| 120 | Papilledema (HP:0001085) | 1.87296541 |
| 121 | Abnormality of the lower motor neuron (HP:0002366) | 1.86787801 |
| 122 | Neurofibrillary tangles (HP:0002185) | 1.86384779 |
| 123 | Psychosis (HP:0000709) | 1.85879751 |
| 124 | Spastic paraplegia (HP:0001258) | 1.85175078 |
| 125 | Poor coordination (HP:0002370) | 1.84348831 |
| 126 | Dysmetric saccades (HP:0000641) | 1.81830445 |
| 127 | Insidious onset (HP:0003587) | 1.81805451 |
| 128 | Termporal pattern (HP:0011008) | 1.81805451 |
| 129 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.81764297 |
| 130 | Spastic tetraplegia (HP:0002510) | 1.78978324 |
| 131 | Dyskinesia (HP:0100660) | 1.75497376 |
| 132 | Decreased number of peripheral myelinated nerve fibers (HP:0003380) | 1.72557080 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.67129765 |
| 2 | CASK | 4.49073020 |
| 3 | MAP3K4 | 3.51721820 |
| 4 | MAP2K7 | 3.42028270 |
| 5 | MAP3K12 | 3.38887976 |
| 6 | EPHA4 | 3.19575073 |
| 7 | MAP3K9 | 2.86498491 |
| 8 | MARK1 | 2.64522079 |
| 9 | MINK1 | 2.29373164 |
| 10 | MAP2K4 | 2.21723466 |
| 11 | TRIM28 | 2.18973833 |
| 12 | MAP4K2 | 2.12778101 |
| 13 | NTRK2 | 2.12153467 |
| 14 | PLK2 | 2.03634942 |
| 15 | CSNK1A1L | 1.79344625 |
| 16 | CSNK1G3 | 1.77659141 |
| 17 | DAPK2 | 1.75818278 |
| 18 | PNCK | 1.71854791 |
| 19 | DAPK1 | 1.69900289 |
| 20 | GRK5 | 1.65211551 |
| 21 | TSSK6 | 1.48014655 |
| 22 | PRPF4B | 1.46419108 |
| 23 | CDK19 | 1.44294300 |
| 24 | ARAF | 1.39329496 |
| 25 | CSNK1G1 | 1.39304775 |
| 26 | NTRK1 | 1.38090209 |
| 27 | AKT3 | 1.37751815 |
| 28 | PRKCG | 1.37108028 |
| 29 | PAK6 | 1.35996898 |
| 30 | MAPK13 | 1.35844845 |
| 31 | ERBB4 | 1.34779597 |
| 32 | CDK5 | 1.34580041 |
| 33 | RIPK4 | 1.34127092 |
| 34 | FES | 1.34048480 |
| 35 | TNIK | 1.31518408 |
| 36 | DYRK2 | 1.25708694 |
| 37 | KSR1 | 1.21489809 |
| 38 | FRK | 1.17088045 |
| 39 | CAMK2A | 1.16973918 |
| 40 | ERBB3 | 1.14541385 |
| 41 | SIK2 | 1.06968501 |
| 42 | KSR2 | 1.06590709 |
| 43 | CCNB1 | 1.06245076 |
| 44 | EPHA3 | 1.06242167 |
| 45 | PDK3 | 1.05822546 |
| 46 | PDK4 | 1.05822546 |
| 47 | LIMK1 | 1.04640642 |
| 48 | NME1 | 1.04615109 |
| 49 | OXSR1 | 1.02188700 |
| 50 | CAMKK1 | 1.01777861 |
| 51 | CAMK2B | 0.95349301 |
| 52 | SGK2 | 0.94314943 |
| 53 | SGK494 | 0.93979114 |
| 54 | SGK223 | 0.93979114 |
| 55 | PRKCE | 0.93057178 |
| 56 | UHMK1 | 0.89672381 |
| 57 | RPS6KA4 | 0.89245230 |
| 58 | SIK3 | 0.87795827 |
| 59 | MUSK | 0.87234085 |
| 60 | PHKG1 | 0.83482791 |
| 61 | PHKG2 | 0.83482791 |
| 62 | STK38L | 0.77619111 |
| 63 | CAMKK2 | 0.76345921 |
| 64 | PRKD3 | 0.76124054 |
| 65 | CDK18 | 0.75149722 |
| 66 | BCKDK | 0.74579897 |
| 67 | WNK3 | 0.74281068 |
| 68 | DYRK1A | 0.74090093 |
| 69 | BMPR2 | 0.73964676 |
| 70 | CDK14 | 0.73622671 |
| 71 | CSNK1G2 | 0.73167874 |
| 72 | MAP3K6 | 0.71860246 |
| 73 | CAMK1 | 0.71059715 |
| 74 | PTK2B | 0.69912702 |
| 75 | CDK15 | 0.69565499 |
| 76 | CDK8 | 0.68769459 |
| 77 | STK38 | 0.68476661 |
| 78 | ADRBK2 | 0.68240384 |
| 79 | MAP3K5 | 0.66343207 |
| 80 | PRKCH | 0.65038746 |
| 81 | TESK1 | 0.64246577 |
| 82 | PDK2 | 0.64021255 |
| 83 | CAMK4 | 0.63395889 |
| 84 | LATS2 | 0.63304533 |
| 85 | BRAF | 0.63110794 |
| 86 | SGK1 | 0.62696181 |
| 87 | BCR | 0.60210201 |
| 88 | CAMK2D | 0.60086492 |
| 89 | CAMK2G | 0.59468167 |
| 90 | MAP3K2 | 0.59171481 |
| 91 | SGK3 | 0.58745413 |
| 92 | CDK11A | 0.58023373 |
| 93 | FER | 0.57696550 |
| 94 | MAP3K13 | 0.55336959 |
| 95 | PAK3 | 0.54881935 |
| 96 | MAPK12 | 0.53187747 |
| 97 | GRK7 | 0.52641054 |
| 98 | TAOK1 | 0.50804660 |
| 99 | STK11 | 0.50058513 |
| 100 | TNK2 | 0.49925239 |
| 101 | ROCK2 | 0.49375607 |
| 102 | CSNK1D | 0.49259458 |
| 103 | PKN1 | 0.49117774 |
| 104 | MYLK | 0.48530187 |
| 105 | TYRO3 | 0.47238391 |
| 106 | FGR | 0.45697061 |
| 107 | RAF1 | 0.45058055 |
| 108 | RPS6KA3 | 0.42991740 |
| 109 | PRKAA1 | 0.41451415 |
| 110 | SRPK1 | 0.40926587 |
| 111 | PRKACA | 0.40276953 |
| 112 | CSNK1A1 | 0.39643467 |
| 113 | PINK1 | 0.39603746 |
| 114 | ADRBK1 | 0.39504799 |
| 115 | RET | 0.38997998 |
| 116 | PRKCZ | 0.38907007 |
| 117 | MAP3K1 | 0.38283981 |
| 118 | PRKCB | 0.37575014 |
| 119 | MAPK10 | 0.36300977 |
| 120 | DAPK3 | 0.36076115 |
| 121 | FGFR2 | 0.35410387 |
| 122 | PDK1 | 0.34907332 |
| 123 | PRKCA | 0.34622232 |
| 124 | FYN | 0.34349671 |
| 125 | RPS6KA5 | 0.34281072 |
| 126 | MAP2K1 | 0.33783238 |
| 127 | PRKACB | 0.33690811 |
| 128 | MAP2K6 | 0.33484666 |
| 129 | MARK2 | 0.32201936 |
| 130 | TAOK3 | 0.32119331 |
| 131 | GRK1 | 0.30520802 |
| 132 | CSNK1E | 0.29135939 |
| 133 | PRKG1 | 0.26034578 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.30950988 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 4.03429879 |
| 3 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 3.14622044 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 3.02195462 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.91267961 |
| 6 | Morphine addiction_Homo sapiens_hsa05032 | 2.56999769 |
| 7 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.54232559 |
| 8 | Olfactory transduction_Homo sapiens_hsa04740 | 2.41521734 |
| 9 | Circadian entrainment_Homo sapiens_hsa04713 | 2.38958436 |
| 10 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.33270132 |
| 11 | Long-term potentiation_Homo sapiens_hsa04720 | 2.28255613 |
| 12 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.20762375 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.01105828 |
| 14 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.96427119 |
| 15 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.93677407 |
| 16 | Taste transduction_Homo sapiens_hsa04742 | 1.89056425 |
| 17 | Salivary secretion_Homo sapiens_hsa04970 | 1.85488878 |
| 18 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.82654752 |
| 19 | Long-term depression_Homo sapiens_hsa04730 | 1.75034802 |
| 20 | Insulin secretion_Homo sapiens_hsa04911 | 1.71542452 |
| 21 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.68294627 |
| 22 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.65218329 |
| 23 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.54247793 |
| 24 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.52040636 |
| 25 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.48723081 |
| 26 | Cocaine addiction_Homo sapiens_hsa05030 | 1.48526610 |
| 27 | Renin secretion_Homo sapiens_hsa04924 | 1.48211548 |
| 28 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.39790620 |
| 29 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.38023921 |
| 30 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.37663093 |
| 31 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.37054227 |
| 32 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.36849660 |
| 33 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.34529786 |
| 34 | Parkinsons disease_Homo sapiens_hsa05012 | 1.30920874 |
| 35 | Alzheimers disease_Homo sapiens_hsa05010 | 1.25404560 |
| 36 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.23890944 |
| 37 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.17607535 |
| 38 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.12573462 |
| 39 | Gap junction_Homo sapiens_hsa04540 | 1.10259965 |
| 40 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.09064139 |
| 41 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.03484287 |
| 42 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.02157895 |
| 43 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.00808325 |
| 44 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.98824209 |
| 45 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.98350475 |
| 46 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.97695685 |
| 47 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.97082304 |
| 48 | Phototransduction_Homo sapiens_hsa04744 | 0.96989498 |
| 49 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.94349245 |
| 50 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.92604318 |
| 51 | Axon guidance_Homo sapiens_hsa04360 | 0.91600026 |
| 52 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.88445334 |
| 53 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.87205107 |
| 54 | Circadian rhythm_Homo sapiens_hsa04710 | 0.84555782 |
| 55 | Huntingtons disease_Homo sapiens_hsa05016 | 0.84066228 |
| 56 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.83035017 |
| 57 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.80668886 |
| 58 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.78265032 |
| 59 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.76460043 |
| 60 | Glioma_Homo sapiens_hsa05214 | 0.75172515 |
| 61 | Melanogenesis_Homo sapiens_hsa04916 | 0.73254855 |
| 62 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.72296605 |
| 63 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.70957064 |
| 64 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.68463427 |
| 65 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.67612797 |
| 66 | Phagosome_Homo sapiens_hsa04145 | 0.65289987 |
| 67 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.61880195 |
| 68 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.60700657 |
| 69 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.59703629 |
| 70 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.57249226 |
| 71 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.54663424 |
| 72 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.53115366 |
| 73 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.52329346 |
| 74 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.50116449 |
| 75 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.49387331 |
| 76 | Alcoholism_Homo sapiens_hsa05034 | 0.47551009 |
| 77 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.47142327 |
| 78 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.45566197 |
| 79 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.44810539 |
| 80 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.43967648 |
| 81 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.43921784 |
| 82 | Protein export_Homo sapiens_hsa03060 | 0.43739434 |
| 83 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.43600170 |
| 84 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.42978366 |
| 85 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.42897552 |
| 86 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.40673080 |
| 87 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.40133645 |
| 88 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.39564242 |
| 89 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.39404257 |
| 90 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.36593572 |
| 91 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.36452675 |
| 92 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.35034365 |
| 93 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.34859603 |
| 94 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.34690055 |
| 95 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.33376847 |
| 96 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.33075875 |
| 97 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.32888401 |
| 98 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.32735589 |
| 99 | Peroxisome_Homo sapiens_hsa04146 | 0.32568666 |
| 100 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.30596610 |
| 101 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.30492891 |
| 102 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.29284730 |
| 103 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.27529696 |
| 104 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.27193118 |
| 105 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.26767870 |
| 106 | Melanoma_Homo sapiens_hsa05218 | 0.24970803 |
| 107 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.23157021 |
| 108 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.22522603 |
| 109 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.22518741 |
| 110 | Prion diseases_Homo sapiens_hsa05020 | 0.21963381 |
| 111 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.21665666 |
| 112 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.20999977 |
| 113 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.20688807 |
| 114 | Bile secretion_Homo sapiens_hsa04976 | 0.20668679 |
| 115 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.20648520 |
| 116 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.19399373 |
| 117 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.19385151 |
| 118 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.19289908 |
| 119 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.18827691 |
| 120 | Endocytosis_Homo sapiens_hsa04144 | 0.16670558 |
| 121 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.16580726 |

