VSTM2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.02528445
2central nervous system myelination (GO:0022010)5.97299363
3axon ensheathment in central nervous system (GO:0032291)5.97299363
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.95236709
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.77737355
6neuron cell-cell adhesion (GO:0007158)5.73682287
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.72642191
8protein localization to synapse (GO:0035418)5.50078391
9synaptic vesicle exocytosis (GO:0016079)5.45522656
10locomotory exploration behavior (GO:0035641)5.43169179
11regulation of glutamate receptor signaling pathway (GO:1900449)5.27213811
12glutamate secretion (GO:0014047)5.13806743
13ionotropic glutamate receptor signaling pathway (GO:0035235)5.06957726
14L-amino acid import (GO:0043092)4.99288800
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.91537773
16sodium ion export (GO:0071436)4.89682946
17synaptic vesicle maturation (GO:0016188)4.87339490
18glutamate receptor signaling pathway (GO:0007215)4.69677067
19exploration behavior (GO:0035640)4.63634918
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.63116989
21regulation of synaptic vesicle exocytosis (GO:2000300)4.58919925
22layer formation in cerebral cortex (GO:0021819)4.55774342
23neuronal action potential propagation (GO:0019227)4.45776549
24amino acid import (GO:0043090)4.44475946
25neurotransmitter secretion (GO:0007269)4.36316281
26neuron recognition (GO:0008038)4.32035819
27neurotransmitter-gated ion channel clustering (GO:0072578)4.30598404
28synaptic transmission, glutamatergic (GO:0035249)4.30257969
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.27593521
30dendritic spine morphogenesis (GO:0060997)4.20647652
31neuron-neuron synaptic transmission (GO:0007270)4.18461725
32regulation of neuronal synaptic plasticity (GO:0048168)4.14755206
33negative regulation of synaptic transmission, GABAergic (GO:0032229)4.12907277
34positive regulation of synapse maturation (GO:0090129)4.08771093
35regulation of synaptic vesicle transport (GO:1902803)4.06616376
36synaptic vesicle docking involved in exocytosis (GO:0016081)4.06003125
37postsynaptic membrane organization (GO:0001941)4.05710456
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.05476967
39gamma-aminobutyric acid signaling pathway (GO:0007214)4.04658445
40gamma-aminobutyric acid transport (GO:0015812)4.03286478
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.02730293
42cerebellar granule cell differentiation (GO:0021707)3.99163825
43presynaptic membrane assembly (GO:0097105)3.94656686
44regulation of voltage-gated calcium channel activity (GO:1901385)3.93896225
45long-term memory (GO:0007616)3.92459667
46potassium ion homeostasis (GO:0055075)3.92009843
47positive regulation of dendritic spine morphogenesis (GO:0061003)3.87768417
48positive regulation of membrane potential (GO:0045838)3.87390106
49potassium ion import (GO:0010107)3.85986981
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.85725926
51regulation of dendritic spine morphogenesis (GO:0061001)3.79081831
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.75783385
53long-term synaptic potentiation (GO:0060291)3.74995241
54positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.74928303
55transmission of nerve impulse (GO:0019226)3.72180415
56regulation of postsynaptic membrane potential (GO:0060078)3.70316028
57axonal fasciculation (GO:0007413)3.68604511
58regulation of neurotransmitter transport (GO:0051588)3.67004357
59startle response (GO:0001964)3.61883508
60establishment of mitochondrion localization (GO:0051654)3.60912648
61neurotransmitter transport (GO:0006836)3.60140501
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.58529856
63presynaptic membrane organization (GO:0097090)3.57677860
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.55609334
65regulation of synaptic plasticity (GO:0048167)3.55149171
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.52040180
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.51645412
68acidic amino acid transport (GO:0015800)3.49840479
69proline transport (GO:0015824)3.48892807
70regulation of synapse structural plasticity (GO:0051823)3.46422830
71neurotransmitter uptake (GO:0001504)3.46040933
72positive regulation of dendritic spine development (GO:0060999)3.44279200
73positive regulation of synapse assembly (GO:0051965)3.42011894
74cell communication by electrical coupling (GO:0010644)3.37033239
75synaptic vesicle endocytosis (GO:0048488)3.35428688
76auditory behavior (GO:0031223)3.34067661
77regulation of synapse maturation (GO:0090128)3.33846667
78response to histamine (GO:0034776)3.33115618
79regulation of vesicle fusion (GO:0031338)3.30910991
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28720520
81regulation of neurotransmitter levels (GO:0001505)3.28713222
82cellular sodium ion homeostasis (GO:0006883)3.28677629
83cell migration in hindbrain (GO:0021535)3.27169539
84cellular potassium ion homeostasis (GO:0030007)3.26390089
85synapse assembly (GO:0007416)3.25892780
86negative regulation of dendrite morphogenesis (GO:0050774)3.24136509
87regulation of dendritic spine development (GO:0060998)3.23895233
88learning (GO:0007612)3.21225756
89neuromuscular synaptic transmission (GO:0007274)3.19757101
90regulation of ARF protein signal transduction (GO:0032012)3.19028181
91behavioral defense response (GO:0002209)3.19022443
92behavioral fear response (GO:0001662)3.19022443
93dendritic spine organization (GO:0097061)3.16266607
94membrane depolarization (GO:0051899)3.16046251
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15134084
96innervation (GO:0060384)3.13468992
97regulation of neurotransmitter secretion (GO:0046928)3.13316159
98neuronal ion channel clustering (GO:0045161)3.12883714
99membrane hyperpolarization (GO:0060081)3.12362508
100membrane depolarization during action potential (GO:0086010)3.11648196
101regulation of synaptic transmission, GABAergic (GO:0032228)3.11492173
102cell differentiation in hindbrain (GO:0021533)3.11370010
103L-glutamate transport (GO:0015813)3.10455695
104G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.10090877
105adult walking behavior (GO:0007628)3.08493901
106righting reflex (GO:0060013)3.08360919
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07711918
108positive regulation of synaptic transmission (GO:0050806)3.06194793
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06047186
110social behavior (GO:0035176)3.04495015
111intraspecies interaction between organisms (GO:0051703)3.04495015
112regulation of synaptic transmission (GO:0050804)3.00946730
113positive regulation of neurotransmitter transport (GO:0051590)3.00520439
114synaptic transmission (GO:0007268)3.00378602
115fear response (GO:0042596)3.00307874
116synaptic vesicle transport (GO:0048489)2.99843737
117establishment of synaptic vesicle localization (GO:0097480)2.99843737
118activation of protein kinase A activity (GO:0034199)2.99540674
119neurofilament cytoskeleton organization (GO:0060052)2.99457276
120striatum development (GO:0021756)2.98653525
121regulation of glutamate secretion (GO:0014048)2.98605717
122neuromuscular process controlling balance (GO:0050885)2.97295913
123dendrite morphogenesis (GO:0048813)2.96512827
124mating behavior (GO:0007617)2.95491391
125synapse organization (GO:0050808)2.95307183
126cerebellar Purkinje cell differentiation (GO:0021702)2.93539685
127positive regulation of neurotransmitter secretion (GO:0001956)2.93285854
128long term synaptic depression (GO:0060292)2.93179610
129response to auditory stimulus (GO:0010996)2.92341096
130neuromuscular process controlling posture (GO:0050884)2.90845125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.58190918
2GBX2_23144817_ChIP-Seq_PC3_Human3.94607869
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.28918416
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21506322
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11630396
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77170468
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77170468
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75647355
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.72772145
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72758054
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60832042
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57775578
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.54466518
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47996446
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.47295395
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43841940
17* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23707341
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23587280
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.21516522
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.20437059
21RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.14177758
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13492404
23TAF15_26573619_Chip-Seq_HEK293_Human2.13034952
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11234189
25AR_21572438_ChIP-Seq_LNCaP_Human2.10929173
26* DROSHA_22980978_ChIP-Seq_HELA_Human2.06930348
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04759060
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.04320525
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02134946
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00539261
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95343490
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95010250
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94695765
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74723285
35SMAD4_21799915_ChIP-Seq_A2780_Human1.74586342
36ZNF274_21170338_ChIP-Seq_K562_Hela1.71730413
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67513760
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67415464
39* CBX2_27304074_Chip-Seq_ESCs_Mouse1.62487365
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60294497
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58937916
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56997105
43P300_19829295_ChIP-Seq_ESCs_Human1.56440812
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51438326
45KDM2B_26808549_Chip-Seq_K562_Human1.47991305
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47210594
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.44940493
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44668525
49IGF1R_20145208_ChIP-Seq_DFB_Human1.41731270
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41580798
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.40673968
52FUS_26573619_Chip-Seq_HEK293_Human1.38857592
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38355423
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.38090758
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37834702
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37094225
57* RING1B_27294783_Chip-Seq_ESCs_Mouse1.36996459
58AR_25329375_ChIP-Seq_VCAP_Human1.34920224
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32229494
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.29404162
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27923754
62VDR_22108803_ChIP-Seq_LS180_Human1.27738904
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.27423014
64CTCF_27219007_Chip-Seq_Bcells_Human1.26817082
65RNF2_27304074_Chip-Seq_NSC_Mouse1.26457433
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26144435
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25020058
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23576504
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20390020
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19861417
71STAT3_23295773_ChIP-Seq_U87_Human1.17896978
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17050000
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16879905
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.16652883
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.15636625
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13110548
77AR_19668381_ChIP-Seq_PC3_Human1.13004093
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11004123
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.10155219
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10005108
81* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06420228
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06134228
83ER_23166858_ChIP-Seq_MCF-7_Human1.05958577
84TCF4_23295773_ChIP-Seq_U87_Human1.05715870
85JUN_21703547_ChIP-Seq_K562_Human1.03559722
86AHR_22903824_ChIP-Seq_MCF-7_Human1.03319632
87RUNX2_22187159_ChIP-Seq_PCA_Human1.03268550
88* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02988558
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02882195
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.02496269
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02381355
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02145695
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02087519
94* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01334335
95OCT4_19829295_ChIP-Seq_ESCs_Human1.00640344
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99838546
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99654609
98SMAD_19615063_ChIP-ChIP_OVARY_Human0.99643796
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98560245
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97859830
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97859830
102TP53_18474530_ChIP-ChIP_U2OS_Human0.95448648
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.93031295
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92456544
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91234889
106BCAT_22108803_ChIP-Seq_LS180_Human0.91051675
107TP53_16413492_ChIP-PET_HCT116_Human0.90586920
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.90551200
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90524858
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90275704
111DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89911644
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.89413063
113FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89392794
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89250630
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87370615
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.85745957
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.84847429
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84772040
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84132827
120EGR1_19032775_ChIP-ChIP_M12_Human0.83007939
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82683745
122DPY_21335234_ChIP-Seq_ESCs_Mouse0.82581099
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81347660
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79769502
125SOX9_26525672_Chip-Seq_HEART_Mouse0.79347072
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77810480
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75572345
128KLF4_19829295_ChIP-Seq_ESCs_Human0.75245764
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73802571
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72992413
131MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.70710092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.00057796
2MP0003880_abnormal_central_pattern5.55464921
3MP0003635_abnormal_synaptic_transmissio4.12580125
4MP0009745_abnormal_behavioral_response3.43962754
5MP0004270_analgesia3.35495510
6MP0002063_abnormal_learning/memory/cond3.31265966
7MP0002064_seizures3.17559555
8MP0009046_muscle_twitch3.07151185
9MP0001968_abnormal_touch/_nociception2.95816079
10MP0002572_abnormal_emotion/affect_behav2.88741625
11MP0001486_abnormal_startle_reflex2.66619729
12MP0002272_abnormal_nervous_system2.65117165
13MP0005423_abnormal_somatic_nervous2.60313339
14MP0002734_abnormal_mechanical_nocicepti2.44316340
15MP0002736_abnormal_nociception_after2.39976506
16MP0001501_abnormal_sleep_pattern2.26307352
17MP0002822_catalepsy2.24597950
18MP0002735_abnormal_chemical_nociception2.23098751
19MP0001440_abnormal_grooming_behavior2.22849415
20MP0006276_abnormal_autonomic_nervous2.10716396
21MP0002067_abnormal_sensory_capabilities2.02558459
22MP0002184_abnormal_innervation1.95831824
23MP0003690_abnormal_glial_cell1.94532377
24MP0003329_amyloid_beta_deposits1.90206047
25MP0000778_abnormal_nervous_system1.89886179
26MP0002733_abnormal_thermal_nociception1.89611615
27MP0002557_abnormal_social/conspecific_i1.82862697
28MP0001529_abnormal_vocalization1.81943378
29MP0001970_abnormal_pain_threshold1.79932611
30MP0004858_abnormal_nervous_system1.75839561
31MP0004924_abnormal_behavior1.65399197
32MP0005386_behavior/neurological_phenoty1.65399197
33MP0001984_abnormal_olfaction1.62557385
34MP0008569_lethality_at_weaning1.61306528
35MP0003122_maternal_imprinting1.58578821
36MP0004811_abnormal_neuron_physiology1.56991714
37MP0005645_abnormal_hypothalamus_physiol1.52460982
38MP0002882_abnormal_neuron_morphology1.48202011
39MP0000955_abnormal_spinal_cord1.48097795
40MP0001188_hyperpigmentation1.47221155
41MP0003879_abnormal_hair_cell1.45606568
42MP0009780_abnormal_chondrocyte_physiolo1.43341679
43MP0002066_abnormal_motor_capabilities/c1.41652942
44MP0003787_abnormal_imprinting1.41536692
45MP0002909_abnormal_adrenal_gland1.39666277
46MP0005551_abnormal_eye_electrophysiolog1.37422796
47MP0004142_abnormal_muscle_tone1.36839119
48MP0001905_abnormal_dopamine_level1.36247740
49MP0001502_abnormal_circadian_rhythm1.35140886
50MP0005646_abnormal_pituitary_gland1.33130407
51MP0002152_abnormal_brain_morphology1.16138492
52MP0008877_abnormal_DNA_methylation1.12033004
53MP0004885_abnormal_endolymph1.11791731
54MP0001986_abnormal_taste_sensitivity1.08113151
55MP0000751_myopathy1.06802165
56MP0004742_abnormal_vestibular_system1.06614075
57MP0000013_abnormal_adipose_tissue1.05383163
58MP0002837_dystrophic_cardiac_calcinosis1.03651944
59MP0002229_neurodegeneration1.02435856
60MP0003633_abnormal_nervous_system1.01385188
61MP0004145_abnormal_muscle_electrophysio0.98019683
62MP0003631_nervous_system_phenotype0.97050240
63MP0002752_abnormal_somatic_nervous0.96689104
64MP0001963_abnormal_hearing_physiology0.96657825
65MP0005394_taste/olfaction_phenotype0.89470508
66MP0005499_abnormal_olfactory_system0.89470508
67MP0002069_abnormal_eating/drinking_beha0.89322785
68MP0005409_darkened_coat_color0.89210874
69MP0005167_abnormal_blood-brain_barrier0.89006844
70MP0006072_abnormal_retinal_apoptosis0.88834528
71MP0001664_abnormal_digestion0.87793280
72MP0002653_abnormal_ependyma_morphology0.86729927
73MP0010386_abnormal_urinary_bladder0.86526447
74MP0001346_abnormal_lacrimal_gland0.86238078
75MP0000631_abnormal_neuroendocrine_gland0.85711327
76MP0008872_abnormal_physiological_respon0.85384079
77MP0004085_abnormal_heartbeat0.82998424
78MP0003632_abnormal_nervous_system0.80934279
79MP0001177_atelectasis0.80649341
80MP0008004_abnormal_stomach_pH0.78770487
81MP0002102_abnormal_ear_morphology0.77742283
82MP0000604_amyloidosis0.77498416
83MP0003634_abnormal_glial_cell0.75908870
84MP0004484_altered_response_of0.75538847
85MP0002090_abnormal_vision0.74535626
86MP0000026_abnormal_inner_ear0.73797318
87MP0002876_abnormal_thyroid_physiology0.72695036
88MP0001299_abnormal_eye_distance/0.72295707
89MP0008874_decreased_physiological_sensi0.71307356
90MP0001485_abnormal_pinna_reflex0.70480679
91MP0003861_abnormal_nervous_system0.69767525
92MP0004215_abnormal_myocardial_fiber0.69032937
93MP0004130_abnormal_muscle_cell0.67110085
94MP0005535_abnormal_body_temperature0.66764551
95MP0000920_abnormal_myelination0.66713514
96MP0003123_paternal_imprinting0.66455105
97MP0003137_abnormal_impulse_conducting0.65407540
98MP0002638_abnormal_pupillary_reflex0.65212547
99MP0003121_genomic_imprinting0.63699494
100MP0005623_abnormal_meninges_morphology0.62711612
101MP0003938_abnormal_ear_development0.61186855
102MP0003283_abnormal_digestive_organ0.61134233
103MP0005253_abnormal_eye_physiology0.59997247
104MP0004147_increased_porphyrin_level0.59426336
105MP0001943_abnormal_respiration0.59266917
106MP0003075_altered_response_to0.58226971
107MP0005171_absent_coat_pigmentation0.56387956
108MP0004233_abnormal_muscle_weight0.56201766
109MP0000579_abnormal_nail_morphology0.55924584
110MP0002082_postnatal_lethality0.54916263
111MP0010770_preweaning_lethality0.54916263
112MP0010769_abnormal_survival0.53086782
113MP0000639_abnormal_adrenal_gland0.52856455
114MP0010768_mortality/aging0.50362872
115MP0003183_abnormal_peptide_metabolism0.49482902
116MP0001348_abnormal_lacrimal_gland0.48355234
117MP0000566_synostosis0.47887305

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.39865665
2Myokymia (HP:0002411)6.00651602
3Focal seizures (HP:0007359)5.79829840
4Visual hallucinations (HP:0002367)5.40442796
5Epileptic encephalopathy (HP:0200134)5.12560525
6Atonic seizures (HP:0010819)5.02341126
7Febrile seizures (HP:0002373)4.89680550
8Absence seizures (HP:0002121)4.56540239
9Dialeptic seizures (HP:0011146)4.25714880
10Progressive cerebellar ataxia (HP:0002073)4.11539025
11Generalized tonic-clonic seizures (HP:0002069)3.99982977
12Hyperventilation (HP:0002883)3.96119604
13Broad-based gait (HP:0002136)3.51929871
14Cerebral hypomyelination (HP:0006808)3.51536352
15Supranuclear gaze palsy (HP:0000605)3.41865307
16Amblyopia (HP:0000646)3.16108934
17Progressive inability to walk (HP:0002505)3.12499499
18Peripheral hypomyelination (HP:0007182)3.10136482
19Poor eye contact (HP:0000817)3.05579228
20Cerebral inclusion bodies (HP:0100314)3.00310661
21Dysdiadochokinesis (HP:0002075)2.94443043
22Impaired vibration sensation in the lower limbs (HP:0002166)2.92921709
23Abnormal social behavior (HP:0012433)2.90524177
24Impaired social interactions (HP:0000735)2.90524177
25Excessive salivation (HP:0003781)2.90262009
26Drooling (HP:0002307)2.90262009
27Annular pancreas (HP:0001734)2.89863759
28Gaze-evoked nystagmus (HP:0000640)2.82188154
29Absent speech (HP:0001344)2.81799319
30Tetraplegia (HP:0002445)2.79711852
31Abnormal eating behavior (HP:0100738)2.76556281
32Anxiety (HP:0000739)2.75856463
33Action tremor (HP:0002345)2.75480649
34Epileptiform EEG discharges (HP:0011182)2.73514407
35Neurofibrillary tangles (HP:0002185)2.73268058
36Truncal ataxia (HP:0002078)2.72175955
37Dysmetria (HP:0001310)2.72132401
38Hemiparesis (HP:0001269)2.72012137
39Clonus (HP:0002169)2.71686579
40Mutism (HP:0002300)2.70895064
41Depression (HP:0000716)2.70479873
42Spastic tetraparesis (HP:0001285)2.63499055
43Urinary bladder sphincter dysfunction (HP:0002839)2.61214499
44Diplopia (HP:0000651)2.59651982
45Abnormality of binocular vision (HP:0011514)2.59651982
46EEG with generalized epileptiform discharges (HP:0011198)2.56138973
47Polyphagia (HP:0002591)2.56039585
48Ankle clonus (HP:0011448)2.54054996
49Genetic anticipation (HP:0003743)2.51784476
50Inability to walk (HP:0002540)2.47744907
51Craniofacial dystonia (HP:0012179)2.47544115
52Termporal pattern (HP:0011008)2.41439592
53Insidious onset (HP:0003587)2.41439592
54Abnormality of the lower motor neuron (HP:0002366)2.39415522
55Morphological abnormality of the pyramidal tract (HP:0002062)2.34666363
56Apathy (HP:0000741)2.34158323
57Hypsarrhythmia (HP:0002521)2.33756196
58Generalized myoclonic seizures (HP:0002123)2.31255240
59Urinary urgency (HP:0000012)2.30349642
60Abnormality of the corticospinal tract (HP:0002492)2.30235411
61Gait imbalance (HP:0002141)2.28196042
62Amyotrophic lateral sclerosis (HP:0007354)2.26789085
63Status epilepticus (HP:0002133)2.22544908
64Scanning speech (HP:0002168)2.22043845
65Spastic gait (HP:0002064)2.22012066
66CNS hypomyelination (HP:0003429)2.21989570
67Split foot (HP:0001839)2.21481682
68Fetal akinesia sequence (HP:0001989)2.19075231
69Increased circulating renin level (HP:0000848)2.17815164
70Choreoathetosis (HP:0001266)2.16744369
71Diminished motivation (HP:0000745)2.16533239
72Stereotypic behavior (HP:0000733)2.13761788
73Postural instability (HP:0002172)2.12914157
74Rigidity (HP:0002063)2.07589573
75Impaired smooth pursuit (HP:0007772)2.07482412
76Agitation (HP:0000713)2.06247128
77Limb dystonia (HP:0002451)2.04690268
78Hemiplegia (HP:0002301)2.02948932
79Spastic tetraplegia (HP:0002510)2.00871222
80Aplasia involving bones of the extremities (HP:0009825)2.00188143
81Aplasia involving bones of the upper limbs (HP:0009823)2.00188143
82Aplasia of the phalanges of the hand (HP:0009802)2.00188143
83Bradykinesia (HP:0002067)1.99890449
84Esotropia (HP:0000565)1.99178191
85Rapidly progressive (HP:0003678)1.93733654
86Lower limb muscle weakness (HP:0007340)1.91813043
87Abnormality of salivation (HP:0100755)1.91335881
88Protruding tongue (HP:0010808)1.90168076
89Specific learning disability (HP:0001328)1.89206456
90Torticollis (HP:0000473)1.89030119
91Degeneration of the lateral corticospinal tracts (HP:0002314)1.88957569
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88957569
93Blue irides (HP:0000635)1.87223146
94Retinal dysplasia (HP:0007973)1.86888354
95Anomalous pulmonary venous return (HP:0010772)1.86816795
96Delusions (HP:0000746)1.85973237
97Hypoplasia of the corpus callosum (HP:0002079)1.83713985
98Impaired vibratory sensation (HP:0002495)1.83474100
99Congenital primary aphakia (HP:0007707)1.83333358
100Psychosis (HP:0000709)1.82510057
101Pheochromocytoma (HP:0002666)1.82361072
102Paraplegia (HP:0010550)1.82119596
103Intention tremor (HP:0002080)1.81899797
104Obstructive sleep apnea (HP:0002870)1.80851678
105Focal dystonia (HP:0004373)1.79452349
106Thickened helices (HP:0000391)1.78349253
107Akinesia (HP:0002304)1.77928767
108Papilledema (HP:0001085)1.77925508
109Incomplete penetrance (HP:0003829)1.76608028
110Hand muscle atrophy (HP:0009130)1.76009117
111Abnormality of ocular smooth pursuit (HP:0000617)1.75330258
112Ventricular fibrillation (HP:0001663)1.75211498
113Insomnia (HP:0100785)1.75088684
114Inappropriate behavior (HP:0000719)1.74956721
115Widely spaced teeth (HP:0000687)1.74756976
116Spastic paraplegia (HP:0001258)1.74319160
117Prolonged QT interval (HP:0001657)1.74062093
118Megalencephaly (HP:0001355)1.73247251
119Hypoventilation (HP:0002791)1.73049908
120Medial flaring of the eyebrow (HP:0010747)1.71976700
121Neuronal loss in central nervous system (HP:0002529)1.71320450
122Sleep apnea (HP:0010535)1.69748991
123Gait ataxia (HP:0002066)1.69352472
124Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67416466
125Narrow nasal bridge (HP:0000446)1.66426227
126Genital tract atresia (HP:0001827)1.64813327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.12143116
2EPHA44.13386081
3MAP3K43.42681848
4MAP3K93.34289584
5MARK13.16049398
6CASK3.09507111
7MAP2K72.83585672
8MINK12.65406987
9MAP3K122.46395117
10PNCK2.13429274
11NTRK22.09989521
12RIPK42.09956187
13MAP2K42.01846419
14DAPK21.85431859
15PLK21.75897261
16PAK61.72685174
17SIK21.69563380
18KSR21.60560054
19KSR11.59657344
20FES1.52520488
21NTRK11.51351950
22TNIK1.47953366
23CDK51.47885008
24MAPK131.42500609
25GRK51.41406654
26PRKD31.38109830
27DAPK11.31780107
28PRPF4B1.31636770
29PRKCG1.23642727
30NME11.18916741
31ARAF1.14618345
32CAMK2A1.12011007
33CAMKK11.09437590
34LATS21.08274720
35PHKG11.07235234
36PHKG21.07235234
37UHMK11.02303654
38PKN11.01569821
39TYRO30.96386075
40ERBB40.93525340
41CAMK2B0.92104174
42BMPR20.88631947
43CDK190.88276389
44MAP3K130.87605726
45PTK2B0.87498675
46CDK140.85681573
47CDK180.84953979
48ALK0.84485512
49CDK150.82956767
50MAP3K20.80102899
51STK380.79137795
52FGFR20.78467743
53FER0.77690190
54FGR0.77310877
55TAOK10.77095203
56PAK30.75735020
57DYRK1A0.75595868
58CAMK10.74461763
59STK110.73867272
60CSNK1G20.73847037
61RAF10.72770585
62SGK30.72469135
63MAPK120.71605766
64CDK11A0.71274306
65BRSK10.70914558
66PRKCE0.70589941
67LIMK10.68731527
68DAPK30.67993983
69SGK2230.67401794
70SGK4940.67401794
71CAMK40.67007471
72SGK10.66712696
73GRK70.64615654
74OXSR10.63852052
75ROCK20.61955320
76MARK20.60489248
77CDC42BPA0.59213801
78MAP3K110.58938690
79PRKCZ0.58279638
80MUSK0.56834660
81CAMK2D0.53434156
82RET0.52656036
83MAP3K60.52459724
84CAMK1G0.51692476
85RIPK10.51031768
86DYRK20.49568780
87PRKCH0.48713368
88SGK20.48530417
89AKT30.46672104
90CAMKK20.43403244
91MAP2K10.42864361
92FYN0.41940495
93TNK20.41938787
94STK390.41759380
95RPS6KA30.41212539
96BCR0.40897096
97PRKCA0.40748847
98CAMK2G0.40423622
99PDK10.39774141
100DMPK0.39561304
101WNK30.39200032
102PINK10.38662685
103WNK40.38636081
104PDPK10.37935359
105MAPK100.37454245
106BRAF0.35881594
107NEK60.35153592
108MAPKAPK50.34945418
109MAP3K10.34910260
110PRKACA0.34670458
111ERBB30.34462030
112LMTK20.33804986
113PRKCB0.33500395
114ERBB20.33475133
115CSNK1E0.31732108
116CSNK1G30.31512729
117PRKG10.31357449
118TESK10.28666146
119CSNK1A1L0.28360397
120CSNK1D0.27872060
121MAPK40.27632443
122CAMK1D0.26938854
123PRKD10.26771782
124CSNK1A10.26297436

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.28375995
2Synaptic vesicle cycle_Homo sapiens_hsa047213.35678044
3GABAergic synapse_Homo sapiens_hsa047272.96970215
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95833457
5Long-term potentiation_Homo sapiens_hsa047202.63712993
6Circadian entrainment_Homo sapiens_hsa047132.63088090
7Glutamatergic synapse_Homo sapiens_hsa047242.62818886
8Morphine addiction_Homo sapiens_hsa050322.60400640
9Olfactory transduction_Homo sapiens_hsa047402.45897920
10Amphetamine addiction_Homo sapiens_hsa050312.44446571
11Dopaminergic synapse_Homo sapiens_hsa047282.20376052
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11657006
13Salivary secretion_Homo sapiens_hsa049702.06301391
14Taste transduction_Homo sapiens_hsa047421.96043608
15Collecting duct acid secretion_Homo sapiens_hsa049661.94848048
16Gastric acid secretion_Homo sapiens_hsa049711.85291267
17Serotonergic synapse_Homo sapiens_hsa047261.83511738
18Insulin secretion_Homo sapiens_hsa049111.81561355
19Cholinergic synapse_Homo sapiens_hsa047251.81516419
20Long-term depression_Homo sapiens_hsa047301.80978508
21Cocaine addiction_Homo sapiens_hsa050301.68819336
22Renin secretion_Homo sapiens_hsa049241.68046220
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62562174
24Oxytocin signaling pathway_Homo sapiens_hsa049211.62256033
25Calcium signaling pathway_Homo sapiens_hsa040201.61610607
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57130472
27Phototransduction_Homo sapiens_hsa047441.41975052
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40543871
29Vitamin B6 metabolism_Homo sapiens_hsa007501.40315605
30GnRH signaling pathway_Homo sapiens_hsa049121.37014045
31Axon guidance_Homo sapiens_hsa043601.34313534
32Gap junction_Homo sapiens_hsa045401.33803573
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32510751
34Cardiac muscle contraction_Homo sapiens_hsa042601.28818978
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26079279
36Vibrio cholerae infection_Homo sapiens_hsa051101.23577408
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19577956
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17512285
39cAMP signaling pathway_Homo sapiens_hsa040241.16220118
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15899487
41Estrogen signaling pathway_Homo sapiens_hsa049151.09791284
42Melanogenesis_Homo sapiens_hsa049161.07330766
43Oxidative phosphorylation_Homo sapiens_hsa001901.07190494
44Glioma_Homo sapiens_hsa052141.02482671
45ErbB signaling pathway_Homo sapiens_hsa040120.99564323
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95285579
47Alzheimers disease_Homo sapiens_hsa050100.95263008
48Type II diabetes mellitus_Homo sapiens_hsa049300.94331518
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92231715
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84914205
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.84176758
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82909689
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81504897
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80050143
55Oocyte meiosis_Homo sapiens_hsa041140.78407396
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.74159011
57Choline metabolism in cancer_Homo sapiens_hsa052310.73535077
58Type I diabetes mellitus_Homo sapiens_hsa049400.73432332
59Parkinsons disease_Homo sapiens_hsa050120.73248769
60Dorso-ventral axis formation_Homo sapiens_hsa043200.71307858
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70454736
62Dilated cardiomyopathy_Homo sapiens_hsa054140.70275439
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70132296
64MAPK signaling pathway_Homo sapiens_hsa040100.69637648
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69537113
66Thyroid hormone synthesis_Homo sapiens_hsa049180.68307960
67Pancreatic secretion_Homo sapiens_hsa049720.67511550
68Histidine metabolism_Homo sapiens_hsa003400.64103352
69Arginine and proline metabolism_Homo sapiens_hsa003300.59626327
70Ras signaling pathway_Homo sapiens_hsa040140.59103647
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56817164
72Huntingtons disease_Homo sapiens_hsa050160.54629119
73Glucagon signaling pathway_Homo sapiens_hsa049220.53068437
74Rap1 signaling pathway_Homo sapiens_hsa040150.52319318
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51831273
76Butanoate metabolism_Homo sapiens_hsa006500.49388007
77VEGF signaling pathway_Homo sapiens_hsa043700.48798178
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48347412
79Wnt signaling pathway_Homo sapiens_hsa043100.48149411
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47175155
81Alcoholism_Homo sapiens_hsa050340.47149926
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.46899124
83Prion diseases_Homo sapiens_hsa050200.46784283
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46061104
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44619014
86African trypanosomiasis_Homo sapiens_hsa051430.43964929
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.43111454
88beta-Alanine metabolism_Homo sapiens_hsa004100.42930139
89Renal cell carcinoma_Homo sapiens_hsa052110.37028473
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36534207
91Fatty acid biosynthesis_Homo sapiens_hsa000610.34279057
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33817828
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33768907
94Rheumatoid arthritis_Homo sapiens_hsa053230.33644852
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33601740
96Circadian rhythm_Homo sapiens_hsa047100.33515033
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32965044
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32391372
99Inositol phosphate metabolism_Homo sapiens_hsa005620.31096017
100Arginine biosynthesis_Homo sapiens_hsa002200.30990405
101Hippo signaling pathway_Homo sapiens_hsa043900.29318322
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29087676
103Mineral absorption_Homo sapiens_hsa049780.28857808
104Regulation of autophagy_Homo sapiens_hsa041400.27727424
105Endocytosis_Homo sapiens_hsa041440.26005732
106AMPK signaling pathway_Homo sapiens_hsa041520.25418321
107Insulin signaling pathway_Homo sapiens_hsa049100.25107060
108Bile secretion_Homo sapiens_hsa049760.24496487
109Melanoma_Homo sapiens_hsa052180.24444794
110Tight junction_Homo sapiens_hsa045300.23688161
111mTOR signaling pathway_Homo sapiens_hsa041500.23558346
112Hedgehog signaling pathway_Homo sapiens_hsa043400.23062004
113Endometrial cancer_Homo sapiens_hsa052130.21888465
114Ovarian steroidogenesis_Homo sapiens_hsa049130.21466599
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20639101
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19727963
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19583348

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