VSTM2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.25119991
2synaptic vesicle maturation (GO:0016188)6.48056662
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.18114959
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.80033992
5locomotory exploration behavior (GO:0035641)5.65390661
6cilium or flagellum-dependent cell motility (GO:0001539)5.52775673
7cilium movement (GO:0003341)5.10680892
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.03013969
9regulation of synaptic vesicle exocytosis (GO:2000300)5.02919827
10motile cilium assembly (GO:0044458)4.99576759
11synaptic vesicle exocytosis (GO:0016079)4.94295204
12vocalization behavior (GO:0071625)4.86530353
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65762919
14glutamate secretion (GO:0014047)4.64376422
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.53354282
16layer formation in cerebral cortex (GO:0021819)4.49246871
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.45058743
18regulation of synaptic vesicle transport (GO:1902803)4.41412950
19regulation of glutamate receptor signaling pathway (GO:1900449)4.41064346
20epithelial cilium movement (GO:0003351)4.33787085
21neurotransmitter secretion (GO:0007269)4.31605716
22regulation of neuronal synaptic plasticity (GO:0048168)4.29109837
23cerebellar granule cell differentiation (GO:0021707)4.23664265
24exploration behavior (GO:0035640)4.18658644
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.14116513
26protein localization to synapse (GO:0035418)4.11016014
27regulation of synapse structural plasticity (GO:0051823)4.07572878
28dendritic spine morphogenesis (GO:0060997)4.05443408
29activation of protein kinase A activity (GO:0034199)4.03991464
30positive regulation of synaptic transmission, GABAergic (GO:0032230)3.92954860
31proline transport (GO:0015824)3.89761396
32neuron cell-cell adhesion (GO:0007158)3.81383338
33gamma-aminobutyric acid transport (GO:0015812)3.80559321
34regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.74603216
35cerebellar Purkinje cell layer development (GO:0021680)3.73624707
36left/right pattern formation (GO:0060972)3.70186212
37neuromuscular process controlling balance (GO:0050885)3.69202747
38ionotropic glutamate receptor signaling pathway (GO:0035235)3.67390350
39glycine transport (GO:0015816)3.65165564
40neuronal action potential propagation (GO:0019227)3.63429522
41regulation of voltage-gated calcium channel activity (GO:1901385)3.50090013
42positive regulation of membrane potential (GO:0045838)3.49231260
43neurotransmitter-gated ion channel clustering (GO:0072578)3.46871686
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45565986
45sodium ion export (GO:0071436)3.42241197
46synaptic transmission, glutamatergic (GO:0035249)3.42063052
47axoneme assembly (GO:0035082)3.41814072
48potassium ion homeostasis (GO:0055075)3.41318043
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.41116508
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.39762620
51auditory behavior (GO:0031223)3.37729387
52cellular potassium ion homeostasis (GO:0030007)3.37705999
53neuromuscular process controlling posture (GO:0050884)3.36891501
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.36321132
55neurotransmitter transport (GO:0006836)3.35383449
56neuronal ion channel clustering (GO:0045161)3.32442907
57long-term memory (GO:0007616)3.29397661
58chemosensory behavior (GO:0007635)3.28022282
59positive regulation of dendritic spine development (GO:0060999)3.27965308
60regulation of ARF protein signal transduction (GO:0032012)3.23594438
61cell communication by electrical coupling (GO:0010644)3.23193909
62regulation of calcium ion-dependent exocytosis (GO:0017158)3.22084426
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21123883
64regulation of excitatory postsynaptic membrane potential (GO:0060079)3.20927049
65regulation of synaptic plasticity (GO:0048167)3.20791426
66vesicle transport along microtubule (GO:0047496)3.18170947
67G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.17984022
68neuron-neuron synaptic transmission (GO:0007270)3.17122948
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16816214
70regulation of dendritic spine morphogenesis (GO:0061001)3.15857882
71prepulse inhibition (GO:0060134)3.14701015
72regulation of neurotransmitter secretion (GO:0046928)3.13016273
73synaptic vesicle endocytosis (GO:0048488)3.11980972
74regulation of vesicle fusion (GO:0031338)3.10884816
75response to auditory stimulus (GO:0010996)3.09925011
76dendrite morphogenesis (GO:0048813)3.09846285
77transmission of nerve impulse (GO:0019226)3.09666730
78regulation of neurotransmitter levels (GO:0001505)3.08896419
79neuron recognition (GO:0008038)3.07911865
80regulation of postsynaptic membrane potential (GO:0060078)3.04401310
81cell migration in hindbrain (GO:0021535)3.04348280
82glutamate receptor signaling pathway (GO:0007215)3.03674745
83detection of calcium ion (GO:0005513)3.03517748
84apical protein localization (GO:0045176)3.00091420
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00043711
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.99851304
87postsynaptic membrane organization (GO:0001941)2.96467322
88neuromuscular process (GO:0050905)2.96280081
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96110168
90dendritic spine organization (GO:0097061)2.95489107
91lung epithelium development (GO:0060428)2.95372316
92regulation of synapse maturation (GO:0090128)2.94560230
93cellular sodium ion homeostasis (GO:0006883)2.94066929
94L-amino acid import (GO:0043092)2.93473350
95mating behavior (GO:0007617)2.92745028
96microtubule bundle formation (GO:0001578)2.92040010
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91401345
98axon ensheathment in central nervous system (GO:0032291)2.91366714
99central nervous system myelination (GO:0022010)2.91366714
100membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.91346386
101positive regulation of synapse maturation (GO:0090129)2.90975685
102insulin secretion (GO:0030073)2.89924499
103organelle transport along microtubule (GO:0072384)2.87486232
104regulation of neurotransmitter transport (GO:0051588)2.87295259
105positive regulation of dendritic spine morphogenesis (GO:0061003)2.85514864
106positive regulation of neurotransmitter transport (GO:0051590)2.84781979
107signal release (GO:0023061)2.84670975
108negative regulation of dendrite morphogenesis (GO:0050774)2.83306105
109adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.82024236
110axon cargo transport (GO:0008088)2.81368605
111regulation of cAMP-dependent protein kinase activity (GO:2000479)2.81194470
112axonal fasciculation (GO:0007413)2.79700292
113innervation (GO:0060384)2.79523237
114regulation of female receptivity (GO:0045924)2.79511664
115membrane depolarization during action potential (GO:0086010)2.79438850
116regulation of dendritic spine development (GO:0060998)2.79392019
117positive regulation of neurotransmitter secretion (GO:0001956)2.79099447
118amino acid import (GO:0043090)2.79028395
119potassium ion import (GO:0010107)2.78874107
120regulation of synaptic transmission, GABAergic (GO:0032228)2.77948446
121regulation of synaptic transmission, glutamatergic (GO:0051966)2.77767045
122cellular response to glucagon stimulus (GO:0071377)2.77585876
123intraspecies interaction between organisms (GO:0051703)2.77412356
124social behavior (GO:0035176)2.77412356
125cerebellar Purkinje cell differentiation (GO:0021702)2.76860597
126positive regulation of exocytosis (GO:0045921)2.75371944
127dopamine receptor signaling pathway (GO:0007212)2.74882857
128regulation of exocytosis (GO:0017157)2.74391204
129membrane repolarization (GO:0086009)2.73757485
130cell communication involved in cardiac conduction (GO:0086065)2.73227435
131negative regulation of inclusion body assembly (GO:0090084)2.69872054
132membrane depolarization (GO:0051899)2.69415905
133regulation of cell communication by electrical coupling (GO:0010649)2.68413521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28739257
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.06943741
3* REST_21632747_ChIP-Seq_MESCs_Mouse3.06223777
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.99998787
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93829229
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84784075
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84463286
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.70099631
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65694886
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61312231
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.59358374
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55370018
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55370018
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52171311
15DROSHA_22980978_ChIP-Seq_HELA_Human2.52078701
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.44733263
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42616609
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35528368
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32591288
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.31051406
21GBX2_23144817_ChIP-Seq_PC3_Human2.30609288
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.30100353
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27144613
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24414623
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.23039715
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20781157
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08992564
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.97374264
29* ERG_21242973_ChIP-ChIP_JURKAT_Human1.93132042
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92202793
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.85359225
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80231093
33* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.71658724
34KDM2B_26808549_Chip-Seq_K562_Human1.69726950
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65550349
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60708486
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54311993
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53936859
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52206388
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.49566531
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47717188
42AR_21572438_ChIP-Seq_LNCaP_Human1.40759091
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.40399378
44ZNF274_21170338_ChIP-Seq_K562_Hela1.36982221
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33339401
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31761481
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30679226
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30339207
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27902795
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.27494809
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25007925
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23630724
53CTCF_27219007_Chip-Seq_Bcells_Human1.23330448
54AR_19668381_ChIP-Seq_PC3_Human1.22353674
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.20286983
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19893717
57TET1_21490601_ChIP-Seq_MESCs_Mouse1.18393910
58SMAD4_21799915_ChIP-Seq_A2780_Human1.16587950
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14996776
60* LXR_22292898_ChIP-Seq_THP-1_Human1.14588449
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.12740210
62* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11533957
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11268372
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10916865
65* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10187198
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08393082
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08323309
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08131068
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06490237
70* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03024762
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01809365
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01406890
73* STAT3_23295773_ChIP-Seq_U87_Human1.00860319
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00190393
75CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98747652
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98235388
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98047053
78SMAD3_21741376_ChIP-Seq_ESCs_Human0.96357700
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95661301
80* RNF2_27304074_Chip-Seq_NSC_Mouse0.94741167
81ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94520370
82CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94199465
83KDM2B_26808549_Chip-Seq_DND41_Human0.93682475
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92538744
85KDM2B_26808549_Chip-Seq_JURKAT_Human0.92155085
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91643036
87SMC4_20622854_ChIP-Seq_HELA_Human0.90735485
88* KLF4_19829295_ChIP-Seq_ESCs_Human0.90197125
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90078200
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89514906
91CREB1_26743006_Chip-Seq_LNCaP_Human0.88255938
92P68_20966046_ChIP-Seq_HELA_Human0.87788014
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87614238
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87199937
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86452798
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.86209101
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85306696
98AR_25329375_ChIP-Seq_VCAP_Human0.85109956
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.85015021
100* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84773544
101* SMAD4_21741376_ChIP-Seq_HESCs_Human0.84490412
102* OCT4_19829295_ChIP-Seq_ESCs_Human0.84147766
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83549241
104AHR_22903824_ChIP-Seq_MCF-7_Human0.82900835
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82699562
106TP53_23651856_ChIP-Seq_MEFs_Mouse0.82688273
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.82417509
108PIAS1_25552417_ChIP-Seq_VCAP_Human0.82390417
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82068183
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81982282
111BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81769296
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81503096
113IGF1R_20145208_ChIP-Seq_DFB_Human0.81422569
114* TCF4_23295773_ChIP-Seq_U87_Human0.81414527
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.80915513
116TP63_22573176_ChIP-Seq_HFKS_Human0.80447210
117TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78873638
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78573186
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78362728
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77053410
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.76781953
122* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76771363
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.76600400
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.75600419
125SA1_27219007_Chip-Seq_ERYTHROID_Human0.73464411
126RACK7_27058665_Chip-Seq_MCF-7_Human0.72929077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.13406279
2MP0003635_abnormal_synaptic_transmissio3.94297393
3MP0004270_analgesia3.86005377
4MP0003880_abnormal_central_pattern3.42704487
5MP0002909_abnormal_adrenal_gland3.21005611
6MP0002063_abnormal_learning/memory/cond3.16779611
7MP0003283_abnormal_digestive_organ3.12421906
8MP0009780_abnormal_chondrocyte_physiolo3.12356983
9MP0002822_catalepsy3.05969916
10MP0009745_abnormal_behavioral_response2.98809067
11MP0002064_seizures2.75962215
12MP0002572_abnormal_emotion/affect_behav2.57137065
13MP0002734_abnormal_mechanical_nocicepti2.54591901
14MP0005423_abnormal_somatic_nervous2.52252600
15MP0001968_abnormal_touch/_nociception2.40648243
16MP0009046_muscle_twitch2.40171257
17MP0002272_abnormal_nervous_system2.24661635
18MP0002733_abnormal_thermal_nociception2.24295073
19MP0000566_synostosis2.22168057
20MP0001486_abnormal_startle_reflex2.18441190
21MP0001970_abnormal_pain_threshold2.06054734
22MP0004858_abnormal_nervous_system2.04404969
23MP0002653_abnormal_ependyma_morphology2.02316025
24MP0000013_abnormal_adipose_tissue1.88183559
25MP0001501_abnormal_sleep_pattern1.88033207
26MP0003329_amyloid_beta_deposits1.85158230
27MP0004811_abnormal_neuron_physiology1.84654525
28MP0005646_abnormal_pituitary_gland1.77752056
29MP0000955_abnormal_spinal_cord1.73820826
30MP0005645_abnormal_hypothalamus_physiol1.68686261
31MP0008569_lethality_at_weaning1.67900672
32MP0002735_abnormal_chemical_nociception1.64154805
33MP0001440_abnormal_grooming_behavior1.62251220
34MP0002557_abnormal_social/conspecific_i1.60152222
35MP0002736_abnormal_nociception_after1.59830823
36MP0005623_abnormal_meninges_morphology1.58221378
37MP0002067_abnormal_sensory_capabilities1.57305720
38MP0002184_abnormal_innervation1.54197542
39MP0008961_abnormal_basal_metabolism1.53716090
40MP0005386_behavior/neurological_phenoty1.52894724
41MP0004924_abnormal_behavior1.52894724
42MP0003879_abnormal_hair_cell1.51563524
43MP0008875_abnormal_xenobiotic_pharmacok1.47277782
44MP0004885_abnormal_endolymph1.47004564
45MP0000778_abnormal_nervous_system1.43326614
46MP0002693_abnormal_pancreas_physiology1.41671696
47MP0004043_abnormal_pH_regulation1.39931550
48MP0003787_abnormal_imprinting1.39896902
49MP0003633_abnormal_nervous_system1.38134363
50MP0003122_maternal_imprinting1.36412091
51MP0002066_abnormal_motor_capabilities/c1.36342407
52MP0002877_abnormal_melanocyte_morpholog1.35027474
53MP0002882_abnormal_neuron_morphology1.33873090
54MP0003172_abnormal_lysosome_physiology1.28707837
55MP0004133_heterotaxia1.27203328
56MP0010386_abnormal_urinary_bladder1.26547431
57MP0001944_abnormal_pancreas_morphology1.24424159
58MP0001502_abnormal_circadian_rhythm1.24181726
59MP0003123_paternal_imprinting1.23303486
60MP0006276_abnormal_autonomic_nervous1.20710433
61MP0001984_abnormal_olfaction1.18477990
62MP0003075_altered_response_to1.10984606
63MP0001346_abnormal_lacrimal_gland1.09869364
64MP0004742_abnormal_vestibular_system1.09348381
65MP0002069_abnormal_eating/drinking_beha1.04366671
66MP0003631_nervous_system_phenotype1.03137809
67MP0005535_abnormal_body_temperature1.02517859
68MP0002152_abnormal_brain_morphology1.00697568
69MP0003634_abnormal_glial_cell1.00145521
70MP0004145_abnormal_muscle_electrophysio0.99324317
71MP0001188_hyperpigmentation0.98395366
72MP0006072_abnormal_retinal_apoptosis0.96960499
73MP0002229_neurodegeneration0.95016126
74MP0005379_endocrine/exocrine_gland_phen0.94866133
75MP0000631_abnormal_neuroendocrine_gland0.94163025
76MP0000678_abnormal_parathyroid_gland0.93281409
77MP0002078_abnormal_glucose_homeostasis0.92823473
78MP0002249_abnormal_larynx_morphology0.90349618
79MP0004142_abnormal_muscle_tone0.90159701
80MP0001963_abnormal_hearing_physiology0.89434563
81MP0002638_abnormal_pupillary_reflex0.88942910
82MP0001529_abnormal_vocalization0.88264296
83MP0004233_abnormal_muscle_weight0.87927036
84MP0005409_darkened_coat_color0.86844812
85MP0002234_abnormal_pharynx_morphology0.86664283
86MP0001348_abnormal_lacrimal_gland0.86306478
87MP0008789_abnormal_olfactory_epithelium0.84354922
88MP0004085_abnormal_heartbeat0.80935062
89MP0000026_abnormal_inner_ear0.80109981
90MP0002752_abnormal_somatic_nervous0.79941220
91MP0000003_abnormal_adipose_tissue0.79331160
92MP0002876_abnormal_thyroid_physiology0.77780079
93MP0003861_abnormal_nervous_system0.77726861
94MP0000579_abnormal_nail_morphology0.77424871
95MP0010234_abnormal_vibrissa_follicle0.76187155
96MP0001299_abnormal_eye_distance/0.76184337
97MP0008874_decreased_physiological_sensi0.75237034
98MP0005187_abnormal_penis_morphology0.75124772
99MP0002837_dystrophic_cardiac_calcinosis0.74768619
100MP0000751_myopathy0.74589071
101MP0003953_abnormal_hormone_level0.74254986
102MP0000604_amyloidosis0.73762097
103MP0003938_abnormal_ear_development0.73418604
104MP0001986_abnormal_taste_sensitivity0.73359307
105MP0001485_abnormal_pinna_reflex0.72532386
106MP0001177_atelectasis0.72012378
107MP0003690_abnormal_glial_cell0.71185568
108MP0005551_abnormal_eye_electrophysiolog0.70005315
109MP0005167_abnormal_blood-brain_barrier0.69201976
110MP0003119_abnormal_digestive_system0.68916058
111MP0001765_abnormal_ion_homeostasis0.67683218
112MP0009379_abnormal_foot_pigmentation0.67334667
113MP0001905_abnormal_dopamine_level0.66614826
114MP0003137_abnormal_impulse_conducting0.66030496
115MP0003183_abnormal_peptide_metabolism0.65589539
116MP0004510_myositis0.65141369
117MP0000639_abnormal_adrenal_gland0.63776452
118MP0005394_taste/olfaction_phenotype0.63636522
119MP0005499_abnormal_olfactory_system0.63636522
120MP0000537_abnormal_urethra_morphology0.61911397
121MP0003632_abnormal_nervous_system0.61225676
122MP0000920_abnormal_myelination0.59705030
123MP0008872_abnormal_physiological_respon0.59664609
124MP0002090_abnormal_vision0.59342861
125MP0003045_fibrosis0.58916375
126MP0000534_abnormal_ureter_morphology0.57747245
127MP0002082_postnatal_lethality0.54954260
128MP0010770_preweaning_lethality0.54954260
129MP0010769_abnormal_survival0.54738744

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.07069426
2Abnormal respiratory epithelium morphology (HP:0012253)7.45155669
3Abnormal respiratory motile cilium morphology (HP:0005938)7.45155669
4Dynein arm defect of respiratory motile cilia (HP:0012255)7.18360764
5Absent/shortened dynein arms (HP:0200106)7.18360764
6Abnormal respiratory motile cilium physiology (HP:0012261)7.16353441
7Abnormal ciliary motility (HP:0012262)7.05316472
8Rhinitis (HP:0012384)6.49871806
9Myokymia (HP:0002411)6.13449491
10Visual hallucinations (HP:0002367)5.35462720
11Focal motor seizures (HP:0011153)5.24190335
12Chronic bronchitis (HP:0004469)4.96504149
13Focal seizures (HP:0007359)4.35792825
14Bronchiectasis (HP:0002110)4.33288015
15Papilledema (HP:0001085)4.21667299
16Nasal polyposis (HP:0100582)4.18560458
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.17201217
18Supranuclear gaze palsy (HP:0000605)3.86990967
19Atonic seizures (HP:0010819)3.56162086
20Epileptic encephalopathy (HP:0200134)3.56100211
21Ankle clonus (HP:0011448)3.54960263
22Action tremor (HP:0002345)3.54790253
23Abnormality of the nasal mucosa (HP:0000433)3.36236434
24Depression (HP:0000716)3.32992097
25Absence seizures (HP:0002121)3.31788697
26Generalized tonic-clonic seizures (HP:0002069)3.11034480
27Anxiety (HP:0000739)2.98402685
28Febrile seizures (HP:0002373)2.95883417
29Progressive cerebellar ataxia (HP:0002073)2.94703948
30Dialeptic seizures (HP:0011146)2.93486866
31Infertility (HP:0000789)2.92638246
32Poor eye contact (HP:0000817)2.88320075
33Ventricular fibrillation (HP:0001663)2.88079981
34Hyperinsulinemic hypoglycemia (HP:0000825)2.86101888
35Postural instability (HP:0002172)2.81503927
36EEG with generalized epileptiform discharges (HP:0011198)2.80921141
37Hypsarrhythmia (HP:0002521)2.80086423
38Impaired vibration sensation in the lower limbs (HP:0002166)2.78839835
39Epileptiform EEG discharges (HP:0011182)2.78192842
40Mutism (HP:0002300)2.77140950
41Agitation (HP:0000713)2.74490481
42Abnormality of the lower motor neuron (HP:0002366)2.73325216
43Impaired social interactions (HP:0000735)2.72166336
44Abnormal social behavior (HP:0012433)2.72166336
45Insomnia (HP:0100785)2.71120443
46Urinary bladder sphincter dysfunction (HP:0002839)2.64400643
47Hypercortisolism (HP:0001578)2.64011625
48Torticollis (HP:0000473)2.63258030
49Neurofibrillary tangles (HP:0002185)2.62489419
50Cerebral inclusion bodies (HP:0100314)2.59988001
51Megalencephaly (HP:0001355)2.59898648
52Annular pancreas (HP:0001734)2.56490408
53Pheochromocytoma (HP:0002666)2.56207061
54Dysdiadochokinesis (HP:0002075)2.51532059
55Impaired smooth pursuit (HP:0007772)2.49088669
56Occipital encephalocele (HP:0002085)2.48649827
57Atelectasis (HP:0100750)2.48625772
58Dysmetria (HP:0001310)2.46653168
59Abnormality of calcium-phosphate metabolism (HP:0100530)2.44807917
60Sleep apnea (HP:0010535)2.42873639
61Large for gestational age (HP:0001520)2.42722358
62Truncal ataxia (HP:0002078)2.42107463
63Abnormal eating behavior (HP:0100738)2.41951702
64Spastic gait (HP:0002064)2.39572320
65Akinesia (HP:0002304)2.38803805
66Male infertility (HP:0003251)2.36982457
67Bundle branch block (HP:0011710)2.36294461
68Broad-based gait (HP:0002136)2.34169642
69Hypoglycemic seizures (HP:0002173)2.33484525
70Focal dystonia (HP:0004373)2.33226460
71Resting tremor (HP:0002322)2.32399719
72Intention tremor (HP:0002080)2.31862495
73Recurrent otitis media (HP:0000403)2.31810480
74Genetic anticipation (HP:0003743)2.31625337
75Bradykinesia (HP:0002067)2.30740656
76Amblyopia (HP:0000646)2.29586940
77Failure to thrive in infancy (HP:0001531)2.28084759
78Urinary urgency (HP:0000012)2.26331995
79Hemiparesis (HP:0001269)2.24841266
80Chronic sinusitis (HP:0011109)2.23470776
81Hemiplegia (HP:0002301)2.19054428
82Drooling (HP:0002307)2.18536032
83Excessive salivation (HP:0003781)2.18536032
84Ankyloglossia (HP:0010296)2.17164939
85Craniofacial dystonia (HP:0012179)2.15797399
86Clonus (HP:0002169)2.15128343
87Insidious onset (HP:0003587)2.14663010
88Termporal pattern (HP:0011008)2.14663010
89Pancreatic islet-cell hyperplasia (HP:0004510)2.14157773
90Limb dystonia (HP:0002451)2.14109268
91Gait imbalance (HP:0002141)2.12619211
92Obstructive sleep apnea (HP:0002870)2.12501202
93Polyphagia (HP:0002591)2.11680477
94Bronchitis (HP:0012387)2.11278181
95Menstrual irregularities (HP:0000858)2.10243797
96Hyperactive renin-angiotensin system (HP:0000841)2.09997354
97Turricephaly (HP:0000262)2.09936281
98Recurrent sinusitis (HP:0011108)2.08281495
99Neuroendocrine neoplasm (HP:0100634)2.04310639
100Hyperparathyroidism (HP:0000843)2.03821579
101Abnormality of endocrine pancreas physiology (HP:0012093)2.02645092
102Abnormality of the pancreatic islet cells (HP:0006476)2.02645092
103Fetal akinesia sequence (HP:0001989)2.02336225
104True hermaphroditism (HP:0010459)2.02059962
105Gaze-evoked nystagmus (HP:0000640)2.01995734
106Amyotrophic lateral sclerosis (HP:0007354)2.01664728
107Pointed chin (HP:0000307)2.01497863
108Lower limb muscle weakness (HP:0007340)2.01363427
109Symptomatic seizures (HP:0011145)2.01181454
110Macroorchidism (HP:0000053)2.00259472
111Urinary glycosaminoglycan excretion (HP:0003541)1.99335982
112Mucopolysacchariduria (HP:0008155)1.99335982
113Abnormality of ocular smooth pursuit (HP:0000617)1.99124418
114Neuronal loss in central nervous system (HP:0002529)1.98129892
115Abnormal EKG (HP:0003115)1.97411461
116Hand muscle atrophy (HP:0009130)1.94143388
117Stereotypic behavior (HP:0000733)1.92870514
118Postural tremor (HP:0002174)1.91851295
119Abnormality of binocular vision (HP:0011514)1.89893037
120Diplopia (HP:0000651)1.89893037
121Cystic liver disease (HP:0006706)1.89267245
122Progressive inability to walk (HP:0002505)1.88660980
123Aplasia involving bones of the upper limbs (HP:0009823)1.88246149
124Aplasia of the phalanges of the hand (HP:0009802)1.88246149
125Aplasia involving bones of the extremities (HP:0009825)1.88246149
126Abnormality of polysaccharide metabolism (HP:0011012)1.87603874
127Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87603874
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87603874
129Insulin-resistant diabetes mellitus (HP:0000831)1.86443166
130Pancreatic fibrosis (HP:0100732)1.86037349
131Abnormality of the corticospinal tract (HP:0002492)1.85913486
132Neoplasm of the peripheral nervous system (HP:0100007)1.83746605
133Increased circulating renin level (HP:0000848)1.83521307
134Apathy (HP:0000741)1.83361628
135Absent speech (HP:0001344)1.82143823
136Status epilepticus (HP:0002133)1.81074256
137Delusions (HP:0000746)1.80468645
138Renal salt wasting (HP:0000127)1.73734276
139Upper limb amyotrophy (HP:0009129)1.72891502
140Distal upper limb amyotrophy (HP:0007149)1.72891502
141Bronchomalacia (HP:0002780)1.72680016
142Nephronophthisis (HP:0000090)1.66078020
143Chronic otitis media (HP:0000389)1.60975290
144Molar tooth sign on MRI (HP:0002419)1.59013484
145Abnormality of midbrain morphology (HP:0002418)1.59013484
146Growth hormone excess (HP:0000845)1.57486399
147Hyperaldosteronism (HP:0000859)1.55056633
148Syncope (HP:0001279)1.48703122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.14439032
2MAP3K93.88396213
3EPHA43.71859911
4PRKD33.20938348
5MARK13.18913382
6MINK12.46015937
7KSR22.42522879
8NTRK12.40363465
9DAPK22.38574197
10MAP3K42.29973892
11PAK62.26025247
12CAMKK12.11195130
13EPHA22.10980813
14MAP3K22.10511972
15UHMK12.02346920
16NTRK21.97530653
17INSRR1.75661633
18CDK51.59433746
19MAP2K71.54783373
20TYRO31.52841852
21DAPK11.52516692
22TAOK11.47038261
23MAP3K11.45769327
24TESK11.43986463
25GRK51.36467311
26PRKCH1.34109715
27SCYL21.30801373
28ALK1.30218900
29MAP2K41.25277216
30CAMKK21.22953186
31PINK11.22443331
32KSR11.21290117
33ICK1.20277456
34PHKG21.19294204
35PHKG11.19294204
36STK381.16787361
37HIPK21.13699203
38SIK21.12769766
39LATS21.09798162
40PDGFRA1.09517529
41LIMK11.07244967
42CDC42BPA1.06687040
43MARK21.05070969
44RET1.03920883
45PRKCG1.02965287
46ARAF1.02574575
47TRIB31.01294780
48MAPK151.01138693
49STK110.97518082
50FES0.95423037
51RIPK40.94319674
52PRKD20.87712418
53MAPK130.86327522
54EPHB20.84926849
55DDR20.84864591
56CAMK2G0.84730081
57PASK0.82828813
58MAPK120.82651895
59PAK30.82380255
60NEK60.80444532
61CDK140.79434760
62PLK20.78290903
63CDK150.77027453
64CAMK2A0.75934928
65RIPK10.75693379
66CDK180.75140311
67PRPF4B0.74074627
68BRSK10.73618875
69CAMK10.70109537
70MAP3K60.69659744
71MAP3K110.69301267
72SGK2230.67995652
73SGK4940.67995652
74CAMK2B0.66478843
75DYRK20.66241870
76CDK11A0.65933438
77PKN10.65358061
78MAP3K120.64271039
79MAP3K130.62849909
80CSNK1G20.62676217
81TAOK30.61945476
82PDPK10.61818651
83SGK10.61809433
84ROCK20.61363806
85BRAF0.60856620
86LMTK20.59884158
87TNIK0.58994748
88PDK10.58081263
89SGK30.57534884
90BCR0.55857529
91RAF10.55712370
92PRKCI0.55082493
93PNCK0.54904672
94RPS6KA30.54892560
95CAMK40.53180388
96PRKCZ0.52378539
97CDK190.51847718
98MST1R0.49489398
99RPS6KA20.48302087
100MAPK100.48281018
101DYRK1A0.46611420
102NEK10.46539388
103ERBB20.45305423
104WNK10.43833678
105CAMK2D0.43459376
106PRKAA10.43369976
107ROCK10.42051355
108DAPK30.41371203
109FYN0.41022847
110WNK40.40885604
111PRKCE0.40507416
112MAP2K10.40232558
113SGK20.39755089
114CAMK1G0.39720870
115TNK20.39328063
116CASK0.39195106
117BMX0.39009855
118PTK2B0.36329248
119PRKACG0.35846393
120PTK20.35451592
121MAP2K60.34970894
122PRKCA0.34808288
123EPHB10.33136605
124CCNB10.30608107
125PRKACA0.29641875

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.04936159
2Insulin secretion_Homo sapiens_hsa049112.69168928
3Nicotine addiction_Homo sapiens_hsa050332.58489917
4Olfactory transduction_Homo sapiens_hsa047402.54962109
5GABAergic synapse_Homo sapiens_hsa047272.53069405
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.46932665
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.38320714
8Circadian entrainment_Homo sapiens_hsa047132.37652947
9Long-term potentiation_Homo sapiens_hsa047202.37466374
10Amphetamine addiction_Homo sapiens_hsa050312.34021701
11Morphine addiction_Homo sapiens_hsa050322.20700301
12Glutamatergic synapse_Homo sapiens_hsa047242.17112261
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11026107
14Dopaminergic synapse_Homo sapiens_hsa047282.07506673
15Cocaine addiction_Homo sapiens_hsa050301.99801836
16Type II diabetes mellitus_Homo sapiens_hsa049301.98209865
17Cholinergic synapse_Homo sapiens_hsa047251.94124278
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88209744
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80684357
20Salivary secretion_Homo sapiens_hsa049701.79673283
21Gastric acid secretion_Homo sapiens_hsa049711.70718928
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64896482
23Taste transduction_Homo sapiens_hsa047421.59334092
24Phenylalanine metabolism_Homo sapiens_hsa003601.53222300
25Renin secretion_Homo sapiens_hsa049241.52384262
26Gap junction_Homo sapiens_hsa045401.46323322
27Histidine metabolism_Homo sapiens_hsa003401.39956578
28Oxytocin signaling pathway_Homo sapiens_hsa049211.39421800
29Long-term depression_Homo sapiens_hsa047301.39418587
30Serotonergic synapse_Homo sapiens_hsa047261.39417110
31GnRH signaling pathway_Homo sapiens_hsa049121.38331305
32Type I diabetes mellitus_Homo sapiens_hsa049401.36646935
33Estrogen signaling pathway_Homo sapiens_hsa049151.30802737
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29530791
35Nitrogen metabolism_Homo sapiens_hsa009101.28453681
36Calcium signaling pathway_Homo sapiens_hsa040201.23522727
37Glioma_Homo sapiens_hsa052141.17599129
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17565646
39cAMP signaling pathway_Homo sapiens_hsa040241.17548229
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17128380
41Pancreatic secretion_Homo sapiens_hsa049721.10741823
42Dorso-ventral axis formation_Homo sapiens_hsa043201.07387673
43Melanogenesis_Homo sapiens_hsa049161.04852054
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04616717
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04125865
46Vibrio cholerae infection_Homo sapiens_hsa051101.04029423
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03985344
48Collecting duct acid secretion_Homo sapiens_hsa049661.02346416
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00123525
50Vitamin B6 metabolism_Homo sapiens_hsa007500.99229423
51ErbB signaling pathway_Homo sapiens_hsa040120.95836496
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94536833
53mTOR signaling pathway_Homo sapiens_hsa041500.94433493
54Tyrosine metabolism_Homo sapiens_hsa003500.92992280
55Thyroid hormone synthesis_Homo sapiens_hsa049180.91029139
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.90978503
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89293510
58beta-Alanine metabolism_Homo sapiens_hsa004100.88987975
59Oocyte meiosis_Homo sapiens_hsa041140.84458641
60Axon guidance_Homo sapiens_hsa043600.84075716
61Glucagon signaling pathway_Homo sapiens_hsa049220.79079669
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79063647
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.78291210
64Tight junction_Homo sapiens_hsa045300.77995617
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76836934
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.76266895
67VEGF signaling pathway_Homo sapiens_hsa043700.73412496
68Prion diseases_Homo sapiens_hsa050200.71732197
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71674367
70Endometrial cancer_Homo sapiens_hsa052130.71291999
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71283156
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71190407
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71107776
74Chemical carcinogenesis_Homo sapiens_hsa052040.67991037
75Insulin signaling pathway_Homo sapiens_hsa049100.67005173
76MAPK signaling pathway_Homo sapiens_hsa040100.65747425
77Alcoholism_Homo sapiens_hsa050340.63942154
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63611005
79Huntingtons disease_Homo sapiens_hsa050160.63120531
80Dilated cardiomyopathy_Homo sapiens_hsa054140.62926832
81Circadian rhythm_Homo sapiens_hsa047100.62057927
82Choline metabolism in cancer_Homo sapiens_hsa052310.61854595
83Hippo signaling pathway_Homo sapiens_hsa043900.61589523
84Cardiac muscle contraction_Homo sapiens_hsa042600.59546454
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59500380
86Endocytosis_Homo sapiens_hsa041440.58925708
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56749668
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56337860
89Prolactin signaling pathway_Homo sapiens_hsa049170.54984307
90Bile secretion_Homo sapiens_hsa049760.54484778
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54275372
92Ras signaling pathway_Homo sapiens_hsa040140.53148820
93Non-small cell lung cancer_Homo sapiens_hsa052230.52790752
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.50917799
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49562541
96Alzheimers disease_Homo sapiens_hsa050100.49439191
97Rap1 signaling pathway_Homo sapiens_hsa040150.48594223
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47734329
99Renal cell carcinoma_Homo sapiens_hsa052110.47641811
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45081837
101Inositol phosphate metabolism_Homo sapiens_hsa005620.44249165
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41743854
103Wnt signaling pathway_Homo sapiens_hsa043100.41480953
104Phototransduction_Homo sapiens_hsa047440.39349933
105N-Glycan biosynthesis_Homo sapiens_hsa005100.39261324
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38174832
107Hedgehog signaling pathway_Homo sapiens_hsa043400.37911910
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37850798
109Lysosome_Homo sapiens_hsa041420.37632617
110Chemokine signaling pathway_Homo sapiens_hsa040620.37218524
111Ovarian steroidogenesis_Homo sapiens_hsa049130.36471914
112Arginine and proline metabolism_Homo sapiens_hsa003300.35164574
113Arginine biosynthesis_Homo sapiens_hsa002200.35088293
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34460540
115Insulin resistance_Homo sapiens_hsa049310.33503561
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.33032586
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32668066
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32514874
119Fatty acid biosynthesis_Homo sapiens_hsa000610.30132481
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29748205
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29465015

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