VSX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)9.67864118
2response to pheromone (GO:0019236)8.44505427
3retinal cone cell development (GO:0046549)8.38060401
4cell differentiation involved in metanephros development (GO:0072202)8.14650140
5photoreceptor cell development (GO:0042461)7.90590979
6glomerulus development (GO:0032835)7.82144048
7eye photoreceptor cell development (GO:0042462)7.73354394
8neuroblast proliferation (GO:0007405)7.25549530
9photoreceptor cell maintenance (GO:0045494)7.23272783
10nephron epithelium morphogenesis (GO:0072088)6.86506212
11nephron tubule morphogenesis (GO:0072078)6.86506212
12rhodopsin mediated signaling pathway (GO:0016056)6.51292391
13G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.38165426
14sodium ion export (GO:0071436)6.24839439
15regulation of rhodopsin mediated signaling pathway (GO:0022400)6.07316431
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.54261618
17relaxation of smooth muscle (GO:0044557)5.44383096
18potassium ion homeostasis (GO:0055075)5.40169775
19cellular potassium ion homeostasis (GO:0030007)5.26488214
20* visual perception (GO:0007601)5.10306868
21* sensory perception of light stimulus (GO:0050953)5.09718268
22renal tubule morphogenesis (GO:0061333)5.09247199
23synaptic vesicle endocytosis (GO:0048488)5.00660637
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.98632213
25innervation (GO:0060384)4.97195769
26positive regulation of synapse maturation (GO:0090129)4.89721922
27detection of light stimulus (GO:0009583)4.87406636
28synaptic vesicle exocytosis (GO:0016079)4.83740019
29detection of visible light (GO:0009584)4.79451531
30retina development in camera-type eye (GO:0060041)4.75185582
31regulation of short-term neuronal synaptic plasticity (GO:0048172)4.72804484
32axonal fasciculation (GO:0007413)4.68236740
33establishment of nucleus localization (GO:0040023)4.66296652
34retina layer formation (GO:0010842)4.65339051
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64152363
36central nervous system projection neuron axonogenesis (GO:0021952)4.50991920
37pancreas development (GO:0031016)4.48514600
38bone remodeling (GO:0046849)4.43569819
39gamma-aminobutyric acid signaling pathway (GO:0007214)4.41486305
40protein-chromophore linkage (GO:0018298)4.41293852
41male genitalia development (GO:0030539)4.40386613
42cell communication by electrical coupling (GO:0010644)4.37291271
43neuronal stem cell maintenance (GO:0097150)4.32838893
44peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.30744887
45cranial nerve morphogenesis (GO:0021602)4.25778105
46pyrimidine nucleobase catabolic process (GO:0006208)4.18916417
47calcium ion import (GO:0070509)4.14478035
48L-glutamate transport (GO:0015813)4.09079297
49regulation of synaptic vesicle exocytosis (GO:2000300)4.08695906
50phototransduction (GO:0007602)4.07581891
51GMP metabolic process (GO:0046037)4.06428264
52eye photoreceptor cell differentiation (GO:0001754)4.06123671
53photoreceptor cell differentiation (GO:0046530)4.06123671
54cell differentiation involved in kidney development (GO:0061005)4.04081018
55protein localization to synapse (GO:0035418)3.97648302
56membrane hyperpolarization (GO:0060081)3.94164258
57regulation of synapse maturation (GO:0090128)3.92825929
58striatum development (GO:0021756)3.90180280
59acidic amino acid transport (GO:0015800)3.89834223
60atrial cardiac muscle cell action potential (GO:0086014)3.88822507
61potassium ion export (GO:0071435)3.86976550
62cellular sodium ion homeostasis (GO:0006883)3.81848112
63phototransduction, visible light (GO:0007603)3.79944355
64positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.73852032
65synaptic vesicle maturation (GO:0016188)3.69472456
66reproductive system development (GO:0061458)3.68535632
67central nervous system neuron axonogenesis (GO:0021955)3.65105029
68layer formation in cerebral cortex (GO:0021819)3.63149153
69detection of external stimulus (GO:0009581)3.60197552
70regulation of voltage-gated calcium channel activity (GO:1901385)3.56270602
71detection of abiotic stimulus (GO:0009582)3.54925071
72hair cell differentiation (GO:0035315)3.54878978
73nucleus localization (GO:0051647)3.54639344
74cellular response to light stimulus (GO:0071482)3.51652291
75nonmotile primary cilium assembly (GO:0035058)3.50867973
76neuron recognition (GO:0008038)3.48053938
77retinal ganglion cell axon guidance (GO:0031290)3.47228127
78positive regulation of mesonephros development (GO:0061213)3.45937671
79positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.45411321
80dendritic spine morphogenesis (GO:0060997)3.45216729
81establishment of synaptic vesicle localization (GO:0097480)3.42745970
82synaptic vesicle transport (GO:0048489)3.42745970
83synaptic vesicle docking involved in exocytosis (GO:0016081)3.42459967
84regulation of synaptic vesicle transport (GO:1902803)3.40887397
85membrane depolarization during action potential (GO:0086010)3.38979862
86inner ear receptor cell differentiation (GO:0060113)3.35796955
87neurotransmitter-gated ion channel clustering (GO:0072578)3.34499443
88regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.31636955
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29365376
90positive regulation of dendritic spine morphogenesis (GO:0061003)3.28395483
91presynaptic membrane assembly (GO:0097105)3.28219965
92regulation of transforming growth factor beta2 production (GO:0032909)3.23117179
93neural precursor cell proliferation (GO:0061351)3.18771882
94pyrimidine dimer repair (GO:0006290)3.18116068
95negative regulation of osteoblast differentiation (GO:0045668)3.16890659
96nucleobase catabolic process (GO:0046113)3.12436800
97muscle cell cellular homeostasis (GO:0046716)3.09750986
98lactate metabolic process (GO:0006089)3.08740025
99mechanoreceptor differentiation (GO:0042490)3.05064952
100neuron fate determination (GO:0048664)3.04991937
101olfactory bulb development (GO:0021772)3.04331460
102intraciliary transport (GO:0042073)3.04051322
103artery development (GO:0060840)3.02348596
104regulation of bile acid biosynthetic process (GO:0070857)3.01238377
105glutamate receptor signaling pathway (GO:0007215)3.00000879
106synapse assembly (GO:0007416)2.99301595
107neuron development (GO:0048666)2.98518941
108positive regulation of cell cycle checkpoint (GO:1901978)2.97082932
109nitric oxide mediated signal transduction (GO:0007263)2.95561188
110homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.95324782
111neurotransmitter secretion (GO:0007269)2.94863064
112regulation of synapse structural plasticity (GO:0051823)2.94705049
113positive regulation of gastrulation (GO:2000543)2.92303439
114interkinetic nuclear migration (GO:0022027)2.91794179
115neuron projection extension involved in neuron projection guidance (GO:1902284)2.91293299
116axon extension involved in axon guidance (GO:0048846)2.91293299
117neurotransmitter transport (GO:0006836)2.91271809
118mating behavior (GO:0007617)2.91012832
119radial glial cell differentiation (GO:0060019)2.90371397
120regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.90102787
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.89213262
122cranial nerve development (GO:0021545)2.87608850
123cellular potassium ion transport (GO:0071804)2.86883558
124potassium ion transmembrane transport (GO:0071805)2.86883558
125ectoderm development (GO:0007398)2.85175774
126regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.84540375
127regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.84517959
128vocalization behavior (GO:0071625)2.84075846
129response to histamine (GO:0034776)2.83419965
130histone H3-K9 modification (GO:0061647)2.82820474
131iron coordination entity transport (GO:1901678)2.82072489
132urinary tract smooth muscle contraction (GO:0014848)2.81357342
133dentate gyrus development (GO:0021542)2.79612297
134glutamate secretion (GO:0014047)2.78481786
135regulation of chemokine-mediated signaling pathway (GO:0070099)2.78119668
136regulation of vesicle fusion (GO:0031338)2.77385716
137axon cargo transport (GO:0008088)2.76745287
138histone H3-K9 methylation (GO:0051567)2.74578443
139presynaptic membrane organization (GO:0097090)2.74206348
140glycolytic process (GO:0006096)2.74002058
141regulation of mesonephros development (GO:0061217)2.71809710
142cornea development in camera-type eye (GO:0061303)2.71097747
143regulation of neurotransmitter secretion (GO:0046928)2.70792694
144camera-type eye morphogenesis (GO:0048593)2.70712239
145apical protein localization (GO:0045176)2.69515670
146positive regulation of sodium ion transmembrane transport (GO:1902307)2.69487808
147embryonic body morphogenesis (GO:0010172)2.65967715
148negative regulation of dendrite development (GO:2000171)2.63750699
149steroid hormone mediated signaling pathway (GO:0043401)2.62039586
150homeostasis of number of cells within a tissue (GO:0048873)2.62034054
151limb development (GO:0060173)2.61519840
152appendage development (GO:0048736)2.61519840
153primitive streak formation (GO:0090009)2.59221157
154glial cell differentiation (GO:0010001)2.59140864
155asymmetric protein localization (GO:0008105)2.55657233
156axonogenesis (GO:0007409)2.55091654
157neuron migration (GO:0001764)2.52330783
158negative regulation of toll-like receptor signaling pathway (GO:0034122)2.48912081
159* neuron differentiation (GO:0030182)2.48322291
160histone H3-K9 demethylation (GO:0033169)2.43344909
161stem cell proliferation (GO:0072089)2.43331934
162inner ear receptor stereocilium organization (GO:0060122)2.41907836
163cerebral cortex radially oriented cell migration (GO:0021799)2.41381493
164genitalia development (GO:0048806)2.41171645
165response to auditory stimulus (GO:0010996)2.39251701
166regulation of timing of cell differentiation (GO:0048505)2.37137604
167regulation of circadian rhythm (GO:0042752)2.36848106
168regulation of growth hormone secretion (GO:0060123)2.36248135
169embryonic digestive tract development (GO:0048566)2.36143382
170coronary vasculature morphogenesis (GO:0060977)2.33294176
171dorsal/ventral axis specification (GO:0009950)2.33058111
172body morphogenesis (GO:0010171)2.32530024
173retinal rod cell development (GO:0046548)11.5164667
174detection of light stimulus involved in visual perception (GO:0050908)11.2220174
175detection of light stimulus involved in sensory perception (GO:0050962)11.2220174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.21609730
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.93411496
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.76559913
4EZH2_22144423_ChIP-Seq_EOC_Human3.72097466
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.98963828
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76982893
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65851918
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.58343512
9REST_21632747_ChIP-Seq_MESCs_Mouse2.53575685
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40752452
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.36278481
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.36024573
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.35216350
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34939843
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.34559634
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33387517
17DROSHA_22980978_ChIP-Seq_HELA_Human2.32357987
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26821109
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23128793
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21659870
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19896175
22POU5F1_16153702_ChIP-ChIP_HESCs_Human2.19286016
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17046537
24IGF1R_20145208_ChIP-Seq_DFB_Human2.14504257
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.11947714
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10350988
27P53_22127205_ChIP-Seq_FIBROBLAST_Human2.07758474
28AR_21572438_ChIP-Seq_LNCaP_Human2.03607724
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.02949201
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02269723
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99181338
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98091571
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.95527449
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94589316
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89415277
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89329921
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89329921
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88185036
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.87343514
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85894938
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.85291853
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85145536
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84626798
44* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81540387
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.80216841
46SMAD4_21799915_ChIP-Seq_A2780_Human1.77983945
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77859855
48TBL1_22424771_ChIP-Seq_293T_Human1.75559410
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71024304
50FUS_26573619_Chip-Seq_HEK293_Human1.70308844
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.67911657
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67837689
53CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.65489398
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.64695657
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.62125944
56RNF2_27304074_Chip-Seq_NSC_Mouse1.60806860
57P300_19829295_ChIP-Seq_ESCs_Human1.56774119
58* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55623950
59NFYB_21822215_ChIP-Seq_K562_Human1.54204248
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.50837994
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49866443
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49866443
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49866443
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49835114
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47534531
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45172737
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.44716151
68AR_19668381_ChIP-Seq_PC3_Human1.43328692
69CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.39710267
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38797624
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36877166
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36792306
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.36071262
74NFYA_21822215_ChIP-Seq_K562_Human1.35769932
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.35415559
76ETV1_20927104_ChIP-Seq_GIST48_Human1.35214270
77WDR5_24793694_ChIP-Seq_LNCAP_Human1.34549003
78STAT3_23295773_ChIP-Seq_U87_Human1.34177609
79CBX2_22325352_ChIP-Seq_293T-Rex_Human1.33910729
80VDR_22108803_ChIP-Seq_LS180_Human1.32965715
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32740902
82EWS_26573619_Chip-Seq_HEK293_Human1.31836416
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31432886
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.30094968
85P53_22387025_ChIP-Seq_ESCs_Mouse1.29654633
86* AR_25329375_ChIP-Seq_VCAP_Human1.29406849
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28977045
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.28041007
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27881354
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.27038593
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.26655425
92KDM2B_26808549_Chip-Seq_REH_Human1.26501520
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26264139
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24173608
95PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.24102931
96PHF8_20622853_ChIP-Seq_HELA_Human1.23147584
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.22589933
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22149476
99CBP_20019798_ChIP-Seq_JUKART_Human1.22149476
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.22026246
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21903758
102CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20613797
103E2F7_22180533_ChIP-Seq_HELA_Human1.20249160
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20171323
105RXR_22108803_ChIP-Seq_LS180_Human1.19958945
106AHR_22903824_ChIP-Seq_MCF-7_Human1.19903902
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19136918
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.18673873
109TCF4_23295773_ChIP-Seq_U87_Human1.18518504
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17833410
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.17801738
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16839263
113SOX2_16153702_ChIP-ChIP_HESCs_Human1.16455661
114SOX9_26525672_Chip-Seq_HEART_Mouse1.16006849
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15848642
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15674330
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15082872
118* ER_23166858_ChIP-Seq_MCF-7_Human1.14917226
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14486442
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14280951
121* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14073856
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13486237
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13354608
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13247456
125NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12975759
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12895030
127MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12832414
128RING1B_27294783_Chip-Seq_NPCs_Mouse1.12169580
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11211849
130SMAD4_21741376_ChIP-Seq_HESCs_Human1.09657512
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06535059
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05901828
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05789915
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.04424540
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03809303
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02972202
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00301036
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.99774424
139TAF15_26573619_Chip-Seq_HEK293_Human0.98535806
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98025113
141KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97677773
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.96891799
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96273761
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96273761
145SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95703894
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.93741791
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.92378274
148RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91747607
149CBP_21632823_ChIP-Seq_H3396_Human0.91724960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog8.35693649
2MP0006072_abnormal_retinal_apoptosis6.13697740
3MP0005253_abnormal_eye_physiology5.16589053
4MP0003011_delayed_dark_adaptation5.16424856
5MP0002090_abnormal_vision4.27654162
6MP0001502_abnormal_circadian_rhythm3.66155535
7MP0003950_abnormal_plasma_membrane3.46431085
8MP0001984_abnormal_olfaction3.45980084
9* MP0005195_abnormal_posterior_eye3.33578086
10MP0006292_abnormal_olfactory_placode3.28466285
11MP0005187_abnormal_penis_morphology2.95262874
12MP0004782_abnormal_surfactant_physiolog2.76412545
13MP0005377_hearing/vestibular/ear_phenot2.73890577
14MP0003878_abnormal_ear_physiology2.73890577
15MP0004233_abnormal_muscle_weight2.60323885
16MP0005391_vision/eye_phenotype2.47633284
17MP0002638_abnormal_pupillary_reflex2.30261818
18MP0002229_neurodegeneration2.13106256
19MP0000566_synostosis2.12554838
20* MP0001324_abnormal_eye_pigmentation1.92950498
21* MP0002752_abnormal_somatic_nervous1.84482851
22MP0001188_hyperpigmentation1.83010640
23MP0001919_abnormal_reproductive_system1.82359615
24MP0002160_abnormal_reproductive_system1.79890969
25MP0005647_abnormal_sex_gland1.78773126
26MP0001293_anophthalmia1.77592772
27MP0003315_abnormal_perineum_morphology1.74485281
28MP0001299_abnormal_eye_distance/1.71892693
29MP0001486_abnormal_startle_reflex1.71336335
30MP0002653_abnormal_ependyma_morphology1.69459770
31MP0005394_taste/olfaction_phenotype1.63686844
32MP0005499_abnormal_olfactory_system1.63686844
33MP0003880_abnormal_central_pattern1.61735845
34MP0004145_abnormal_muscle_electrophysio1.60472669
35MP0008789_abnormal_olfactory_epithelium1.58846318
36MP0004084_abnormal_cardiac_muscle1.57410414
37MP0004215_abnormal_myocardial_fiber1.56414343
38MP0000537_abnormal_urethra_morphology1.54993537
39MP0005423_abnormal_somatic_nervous1.54098925
40* MP0001286_abnormal_eye_development1.52671050
41MP0003635_abnormal_synaptic_transmissio1.50209079
42MP0000631_abnormal_neuroendocrine_gland1.46658121
43MP0002882_abnormal_neuron_morphology1.44704675
44MP0008775_abnormal_heart_ventricle1.41930187
45MP0002064_seizures1.39045923
46MP0002102_abnormal_ear_morphology1.38114391
47MP0002272_abnormal_nervous_system1.34890481
48MP0010030_abnormal_orbit_morphology1.34500866
49MP0010386_abnormal_urinary_bladder1.34353071
50MP0003136_yellow_coat_color1.32551011
51MP0002735_abnormal_chemical_nociception1.31910548
52MP0002184_abnormal_innervation1.29340284
53MP0000049_abnormal_middle_ear1.29171407
54MP0002332_abnormal_exercise_endurance1.27177952
55MP0002063_abnormal_learning/memory/cond1.26077372
56MP0009046_muscle_twitch1.25754147
57MP0002092_abnormal_eye_morphology1.25088230
58MP0002067_abnormal_sensory_capabilities1.24177704
59* MP0005248_abnormal_Harderian_gland1.23497688
60MP0001485_abnormal_pinna_reflex1.21628441
61MP0004036_abnormal_muscle_relaxation1.19426568
62MP0000428_abnormal_craniofacial_morphol1.16699928
63MP0002233_abnormal_nose_morphology1.16643403
64MP0003119_abnormal_digestive_system1.15362071
65MP0005389_reproductive_system_phenotype1.14562021
66MP0004859_abnormal_synaptic_plasticity1.13175451
67MP0002734_abnormal_mechanical_nocicepti1.12912820
68MP0009053_abnormal_anal_canal1.10679009
69MP0001851_eye_inflammation1.09129674
70MP0009745_abnormal_behavioral_response1.05120073
71MP0006276_abnormal_autonomic_nervous1.05016929
72MP0005670_abnormal_white_adipose1.04936499
73MP0005646_abnormal_pituitary_gland1.03860283
74MP0010368_abnormal_lymphatic_system1.03556751
75MP0001968_abnormal_touch/_nociception1.01980087
76MP0002127_abnormal_cardiovascular_syste0.98467280
77MP0000647_abnormal_sebaceous_gland0.96227206
78MP0002572_abnormal_emotion/affect_behav0.94363162
79MP0004885_abnormal_endolymph0.93519351
80MP0001440_abnormal_grooming_behavior0.91950990
81MP0005595_abnormal_vascular_smooth0.90624891
82MP0003634_abnormal_glial_cell0.90155630
83MP0002822_catalepsy0.85961903
84MP0005409_darkened_coat_color0.85605373
85MP0002938_white_spotting0.85203249
86MP0004742_abnormal_vestibular_system0.83729279
87MP0003453_abnormal_keratinocyte_physiol0.83408653
88MP0003137_abnormal_impulse_conducting0.82797019
89MP0005220_abnormal_exocrine_pancreas0.82616292
90MP0001501_abnormal_sleep_pattern0.81717189
91MP0003938_abnormal_ear_development0.80867575
92MP0003329_amyloid_beta_deposits0.80761503
93MP0003787_abnormal_imprinting0.80002753
94MP0002177_abnormal_outer_ear0.79295590
95MP0004858_abnormal_nervous_system0.75963205
96MP0000751_myopathy0.75234949
97MP0002736_abnormal_nociception_after0.74529395
98* MP0002081_perinatal_lethality0.74149911
99MP0002557_abnormal_social/conspecific_i0.73762121
100MP0004085_abnormal_heartbeat0.72058041
101MP0002009_preneoplasia0.71470271
102MP0000778_abnormal_nervous_system0.71232816
103MP0003122_maternal_imprinting0.71114421
104* MP0005193_abnormal_anterior_eye0.70683160
105MP0009697_abnormal_copulation0.69986120
106MP0003890_abnormal_embryonic-extraembry0.68475621
107MP0001529_abnormal_vocalization0.67823474
108MP0008569_lethality_at_weaning0.67343568
109MP0002234_abnormal_pharynx_morphology0.66530329
110MP0005386_behavior/neurological_phenoty0.66253927
111MP0004924_abnormal_behavior0.66253927
112MP0004142_abnormal_muscle_tone0.65903042
113MP0001963_abnormal_hearing_physiology0.65666815
114MP0002909_abnormal_adrenal_gland0.65289086
115MP0002152_abnormal_brain_morphology0.64729702
116MP0004811_abnormal_neuron_physiology0.64434317
117* MP0001340_abnormal_eyelid_morphology0.62397965
118MP0004197_abnormal_fetal_growth/weight/0.60204523
119MP0005620_abnormal_muscle_contractility0.58420812
120MP0004270_analgesia0.57846452
121MP0003879_abnormal_hair_cell0.55978113
122MP0001661_extended_life_span0.55420211
123MP0002066_abnormal_motor_capabilities/c0.54167569
124MP0001764_abnormal_homeostasis0.53706954
125MP0001177_atelectasis0.53452682
126MP0005197_abnormal_uvea_morphology0.52217104
127MP0008004_abnormal_stomach_pH0.52082663
128MP0000534_abnormal_ureter_morphology0.50870534
129* MP0000955_abnormal_spinal_cord0.50788575
130MP0002069_abnormal_eating/drinking_beha0.50549265
131* MP0002697_abnormal_eye_size0.46494719
132MP0002751_abnormal_autonomic_nervous0.46240910
133MP0000026_abnormal_inner_ear0.45954485
134MP0001986_abnormal_taste_sensitivity0.44582437
135MP0008007_abnormal_cellular_replicative0.43945374
136MP0001970_abnormal_pain_threshold0.42718851
137MP0002089_abnormal_postnatal_growth/wei0.42651069
138MP0003861_abnormal_nervous_system0.39614361
139MP0006035_abnormal_mitochondrial_morpho0.39008146
140* MP0003698_abnormal_male_reproductive0.37994234
141MP0003045_fibrosis0.33672220

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)9.18237933
2Central scotoma (HP:0000603)9.06666575
3Severe visual impairment (HP:0001141)8.54629101
4Abnormality of macular pigmentation (HP:0008002)8.07200577
5Absent rod-and cone-mediated responses on ERG (HP:0007688)7.72058215
6Pendular nystagmus (HP:0012043)7.23631721
7Decreased central vision (HP:0007663)7.10069260
8Bony spicule pigmentary retinopathy (HP:0007737)7.00244024
9Scotoma (HP:0000575)6.75742388
10Abolished electroretinogram (ERG) (HP:0000550)6.04678627
11Increased corneal curvature (HP:0100692)5.76199351
12Keratoconus (HP:0000563)5.76199351
13Chorioretinal atrophy (HP:0000533)5.60949714
14Attenuation of retinal blood vessels (HP:0007843)5.01638585
15Pigmentary retinal degeneration (HP:0001146)4.72124632
16Cone-rod dystrophy (HP:0000548)4.54064318
17Dyschromatopsia (HP:0007641)4.37947900
18Septo-optic dysplasia (HP:0100842)4.34460804
19Hypoplasia of the fovea (HP:0007750)4.09905757
20Aplasia/Hypoplasia of the fovea (HP:0008060)4.09905757
21Posterior subcapsular cataract (HP:0007787)3.78033536
22Photophobia (HP:0000613)3.71475894
23Macular degeneration (HP:0000608)3.68184715
24Type II diabetes mellitus (HP:0005978)3.61044578
25Epileptic encephalopathy (HP:0200134)3.50355960
26Abnormality of the fovea (HP:0000493)3.41475619
27Febrile seizures (HP:0002373)3.32683087
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.15528715
29Short 4th metacarpal (HP:0010044)3.15528715
30Oligodactyly (hands) (HP:0001180)3.13102615
31Aplasia/Hypoplasia of the macula (HP:0008059)3.12289686
32Chronic hepatic failure (HP:0100626)3.06838255
33Intestinal atresia (HP:0011100)3.06566281
34Constricted visual fields (HP:0001133)3.03582707
35Oligodactyly (HP:0012165)3.01376217
36Albinism (HP:0001022)2.98837216
37Congenital sensorineural hearing impairment (HP:0008527)2.89762268
38Vitreoretinal degeneration (HP:0000655)2.80760159
39Aplasia/Hypoplasia affecting the retina (HP:0008061)2.80529257
40Renovascular hypertension (HP:0100817)2.76865828
41Retinitis pigmentosa (HP:0000510)2.73915180
42Severe Myopia (HP:0011003)2.65615831
43Papillary thyroid carcinoma (HP:0002895)2.54535995
44True hermaphroditism (HP:0010459)2.50974585
45Subcapsular cataract (HP:0000523)2.50293124
46Abnormality of the 4th metacarpal (HP:0010012)2.44705116
47Tubulointerstitial nephritis (HP:0001970)2.44426806
48Chin dimple (HP:0010751)2.41686527
49Abnormality of the diencephalon (HP:0010662)2.38620790
50Optic nerve hypoplasia (HP:0000609)2.35007697
51Gait imbalance (HP:0002141)2.30906036
52Renal hypoplasia (HP:0000089)2.29839168
53Choroideremia (HP:0001139)2.25524841
54Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.24744319
55Congenital primary aphakia (HP:0007707)2.24077494
56Progressive visual loss (HP:0000529)2.22493211
57Alacrima (HP:0000522)2.19380061
58Absent septum pellucidum (HP:0001331)2.17524349
59Decreased lacrimation (HP:0000633)2.09605700
60Medial flaring of the eyebrow (HP:0010747)2.09314595
61Short chin (HP:0000331)2.07691909
62High anterior hairline (HP:0009890)2.07369882
63Absence seizures (HP:0002121)2.06966161
64Nephrogenic diabetes insipidus (HP:0009806)2.06266188
65Pancreatic fibrosis (HP:0100732)2.02844332
66Cholecystitis (HP:0001082)2.02575251
67Abnormal gallbladder physiology (HP:0012438)2.02575251
68Thyroiditis (HP:0100646)2.01650681
69Congenital stationary night blindness (HP:0007642)14.2302431
70Visual hallucinations (HP:0002367)1.95073217
71Abnormality of the septum pellucidum (HP:0007375)1.90924330
72Gastrointestinal atresia (HP:0002589)1.89891378
73Sclerocornea (HP:0000647)1.89425242
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.88629676
75Prolonged QT interval (HP:0001657)1.87471155
76Anophthalmia (HP:0000528)1.86365585
77Pancreatic cysts (HP:0001737)1.85670435
78Fetal akinesia sequence (HP:0001989)1.84622049
79Difficulty running (HP:0009046)1.84283092
80Poor coordination (HP:0002370)1.83770375
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82978819
82Impaired vibration sensation in the lower limbs (HP:0002166)1.80985611
83Esophageal atresia (HP:0002032)1.80175758
84Overriding aorta (HP:0002623)1.77653634
85Maternal diabetes (HP:0009800)1.77357711
86Increased nuchal translucency (HP:0010880)1.77125173
87Progressive cerebellar ataxia (HP:0002073)1.74211818
88Obsessive-compulsive behavior (HP:0000722)1.73746365
89Elfin facies (HP:0004428)1.73016963
90Abdominal situs inversus (HP:0003363)1.70719915
91Abnormality of abdominal situs (HP:0011620)1.70719915
92Dialeptic seizures (HP:0011146)1.70179188
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69141250
94Medulloblastoma (HP:0002885)1.67466121
95Neoplasm of the heart (HP:0100544)1.67321623
96Abnormality of the aortic arch (HP:0012303)1.65506450
97Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65393102
98Wide nasal bridge (HP:0000431)1.64118135
99Abnormal lung lobation (HP:0002101)1.62781162
100Volvulus (HP:0002580)1.61677104
101Aplasia/Hypoplasia of the lens (HP:0008063)1.59378488
102Growth hormone deficiency (HP:0000824)1.58886886
103Partial agenesis of the corpus callosum (HP:0001338)1.58640944
104Polyphagia (HP:0002591)1.58255600
105Flat cornea (HP:0007720)1.57385996
106Generalized hypopigmentation (HP:0007513)1.57105699
107Astigmatism (HP:0000483)1.56412294
108Bifid tongue (HP:0010297)1.55833714
109Hemiparesis (HP:0001269)1.54527988
110Scanning speech (HP:0002168)1.53408968
111Cutaneous finger syndactyly (HP:0010554)1.52957576
112Double outlet right ventricle (HP:0001719)1.51716445
113Congenital malformation of the right heart (HP:0011723)1.51716445
114Preaxial hand polydactyly (HP:0001177)1.50569740
115Hemivertebrae (HP:0002937)1.49795800
116Aqueductal stenosis (HP:0002410)1.49788880
117Genital tract atresia (HP:0001827)1.48591816
118Vaginal atresia (HP:0000148)1.48539095
119Megalocornea (HP:0000485)1.47666552
120Hyperacusis (HP:0010780)1.47086661
121Dysdiadochokinesis (HP:0002075)1.44719271
122Renal duplication (HP:0000075)1.44464509
123Esotropia (HP:0000565)1.44322499
124Thyroid carcinoma (HP:0002890)1.42923699
125Optic disc pallor (HP:0000543)1.41941992
126Cystic liver disease (HP:0006706)1.40803239
127Insomnia (HP:0100785)1.40459113
128Down-sloping shoulders (HP:0200021)1.39948539
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.38989253
130Ependymoma (HP:0002888)1.38761629
131Omphalocele (HP:0001539)1.37342334
132Limited hip movement (HP:0008800)1.36198494
133Abnormality of the labia minora (HP:0012880)1.34745948
134Median cleft lip (HP:0000161)1.34337860
135Focal motor seizures (HP:0011153)1.33550540
136Abnormality of dental color (HP:0011073)1.32293990
137Hepatoblastoma (HP:0002884)1.31992379
138Gonadotropin excess (HP:0000837)1.31422190
139Depression (HP:0000716)1.28914928
140Mutism (HP:0002300)1.28194958
141Abnormal pupillary function (HP:0007686)1.27397665
142Focal seizures (HP:0007359)1.27389437
143Optic atrophy (HP:0000648)1.27256716
144Abnormality of the astrocytes (HP:0100707)1.26604680
145Astrocytoma (HP:0009592)1.26604680
146Abnormality of the sella turcica (HP:0002679)1.24753892
147EEG with generalized epileptiform discharges (HP:0011198)1.24441823
148Epileptiform EEG discharges (HP:0011182)1.21428921
149Genetic anticipation (HP:0003743)1.20827792
150Glioma (HP:0009733)1.18312633
151Left ventricular hypertrophy (HP:0001712)1.17512668
152Hypoventilation (HP:0002791)1.16525998
153Abnormal EKG (HP:0003115)1.16021062
154Specific learning disability (HP:0001328)1.14078185
155Polar cataract (HP:0010696)1.13980152
156Atrial fibrillation (HP:0005110)1.13332904
157Abnormality of the lower motor neuron (HP:0002366)1.11870520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.67590449
2NEK14.09861368
3EPHA33.46877700
4PRPF4B3.31745572
5PAK63.20886924
6GRK13.12061712
7MKNK22.92932975
8TAOK22.89386827
9DYRK1A2.63088380
10CDK82.31067652
11BCR2.24355003
12TNK22.18429346
13MKNK12.17293575
14CLK11.98567930
15STK381.96220883
16TLK11.89750370
17INSRR1.86710340
18CASK1.83533959
19MAP3K41.83102933
20MAP3K71.80891665
21PINK11.79490324
22CDK191.78481888
23MARK11.75871769
24AKT31.75546911
25SGK4941.70761239
26SGK2231.70761239
27ZAK1.66707143
28PNCK1.65907133
29ICK1.60247189
30RIPK11.58147599
31MINK11.58079329
32TNIK1.50910648
33STK38L1.50854795
34CAMK1D1.50841982
35PLK41.46492417
36PHKG11.45269347
37PHKG21.45269347
38MAP2K71.43988428
39LATS11.40536393
40CAMK1G1.29776743
41NME11.27175296
42CSNK1G11.23971460
43NTRK31.23682899
44IRAK21.20955670
45SGK21.20494612
46CDK91.19658411
47CDK31.19271497
48MAP3K61.18563283
49TYRO31.13097644
50NTRK21.11900628
51ERBB31.11800868
52DYRK31.11792459
53ERBB21.05853272
54DYRK21.04744167
55KSR11.03338166
56CCNB11.02195432
57DYRK1B1.01875713
58MAP4K21.01597428
59PLK30.97588071
60PASK0.95358765
61HIPK20.93309955
62CDC70.92050158
63BRD40.91718367
64STK40.88196861
65PRKAA10.87345523
66CAMK2D0.87223994
67CAMKK10.85730893
68CSNK1G20.84326277
69PIK3CA0.84255656
70LATS20.81292366
71EPHA40.80948032
72FES0.80427330
73SRPK10.78595648
74CDK50.75858449
75STK390.75076386
76CDK150.74916981
77CDK140.73965676
78PKN10.73815721
79CDK180.73188628
80MAP2K40.72599887
81PDGFRB0.71758185
82PBK0.69500822
83RET0.68931761
84MAP3K100.68495214
85PRKCG0.68014411
86CSNK1G30.67865639
87CDC42BPA0.67747017
88STK110.67601674
89GSK3B0.66388143
90MAP3K130.66383472
91PRKG10.64555237
92MET0.64240651
93CDK11A0.63333840
94YES10.63196401
95CAMK2A0.63115399
96RPS6KA30.62081176
97MAPK100.61816908
98SGK30.61647990
99MAPK90.61419082
100PRKCE0.59931644
101PAK30.58113721
102CSNK1E0.57759547
103FGFR20.57540474
104PRKCZ0.57479562
105CAMK10.55214754
106DAPK20.55170122
107MTOR0.55162060
108KDR0.54665184
109PRKCB0.54656770
110TAF10.54638994
111MAPK140.54281143
112MAPK130.54240230
113RPS6KA50.53942369
114SGK10.53476560
115SIK20.53123523
116BTK0.52914212
117MAP3K90.52899865
118WNK10.52727374
119CDK10.52123393
120ROCK20.51273762
121WEE10.51095846
122PRKACA0.50120063
123BRAF0.49941289
124PRKCA0.48620840
125ATM0.48205086
126MAPK80.47743227
127VRK10.47176108
128SIK10.47114652
129FYN0.46789550
130PLK20.46637098
131NEK60.46207805
132RPS6KC10.45058209
133RPS6KL10.45058209
134CAMK40.44053792
135ATR0.42822321
136CHEK20.42523198
137ROCK10.42438016
138AURKA0.42069898
139RPS6KA60.42039621
140FER0.41948756
141PRKACB0.41303870
142NTRK10.40650635
143CAMKK20.40311183
144GRK50.39651057
145CSNK1A1L0.38232553
146RPS6KA20.37954841
147FRK0.37574859
148FGFR10.37321178
149CSNK1D0.36240882
150MARK20.35574559
151UHMK10.35104889
152MAPK10.34919004
153CDK20.34025195

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.05550958
2Nicotine addiction_Homo sapiens_hsa050334.11946292
3Synaptic vesicle cycle_Homo sapiens_hsa047213.82217871
4GABAergic synapse_Homo sapiens_hsa047273.76854254
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.98955907
6Circadian rhythm_Homo sapiens_hsa047102.97120941
7Morphine addiction_Homo sapiens_hsa050322.95368282
8Circadian entrainment_Homo sapiens_hsa047132.38885662
9Olfactory transduction_Homo sapiens_hsa047402.38112960
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.08439623
11Fructose and mannose metabolism_Homo sapiens_hsa000511.97814763
12Insulin secretion_Homo sapiens_hsa049111.96443968
13Basal cell carcinoma_Homo sapiens_hsa052171.91903369
14Hedgehog signaling pathway_Homo sapiens_hsa043401.90764692
15Non-small cell lung cancer_Homo sapiens_hsa052231.86656833
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83189451
17Cholinergic synapse_Homo sapiens_hsa047251.79118544
18Glutamatergic synapse_Homo sapiens_hsa047241.74190893
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71405211
20Non-homologous end-joining_Homo sapiens_hsa034501.64291465
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.62939472
22Renin secretion_Homo sapiens_hsa049241.62075648
23Notch signaling pathway_Homo sapiens_hsa043301.59092862
24Serotonergic synapse_Homo sapiens_hsa047261.56640442
25Oxytocin signaling pathway_Homo sapiens_hsa049211.48163619
26Salivary secretion_Homo sapiens_hsa049701.45809507
27Dilated cardiomyopathy_Homo sapiens_hsa054141.35989056
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35576857
29Thyroid cancer_Homo sapiens_hsa052161.35374490
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35297149
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33125970
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30875357
33Cardiac muscle contraction_Homo sapiens_hsa042601.28871152
34Collecting duct acid secretion_Homo sapiens_hsa049661.28055608
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23699646
36Dopaminergic synapse_Homo sapiens_hsa047281.23537000
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21640313
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.14803267
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14464801
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12543522
41Mineral absorption_Homo sapiens_hsa049781.05480779
42Biosynthesis of amino acids_Homo sapiens_hsa012301.03573141
43Calcium signaling pathway_Homo sapiens_hsa040201.03458057
44Prolactin signaling pathway_Homo sapiens_hsa049171.02781155
45Propanoate metabolism_Homo sapiens_hsa006401.02176312
46Dorso-ventral axis formation_Homo sapiens_hsa043201.01770683
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01740697
48Taste transduction_Homo sapiens_hsa047420.95394680
49Cell cycle_Homo sapiens_hsa041100.92136376
50Type II diabetes mellitus_Homo sapiens_hsa049300.92111284
51Galactose metabolism_Homo sapiens_hsa000520.89632217
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89556868
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88432544
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87811209
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.86011884
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84895634
57Prostate cancer_Homo sapiens_hsa052150.81818231
58MicroRNAs in cancer_Homo sapiens_hsa052060.81726632
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80854861
60Inositol phosphate metabolism_Homo sapiens_hsa005620.79832757
61Tight junction_Homo sapiens_hsa045300.79742229
62Pentose phosphate pathway_Homo sapiens_hsa000300.77602439
63mTOR signaling pathway_Homo sapiens_hsa041500.76173666
64Chronic myeloid leukemia_Homo sapiens_hsa052200.75388266
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75379031
66Alcoholism_Homo sapiens_hsa050340.74705566
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74581515
68Small cell lung cancer_Homo sapiens_hsa052220.73567535
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73534734
70cAMP signaling pathway_Homo sapiens_hsa040240.73296091
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.73165089
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72264816
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72058828
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69612045
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67983552
76mRNA surveillance pathway_Homo sapiens_hsa030150.66237583
77Butanoate metabolism_Homo sapiens_hsa006500.64867144
78Pathways in cancer_Homo sapiens_hsa052000.62146799
79Gap junction_Homo sapiens_hsa045400.61578164
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61556061
81Melanogenesis_Homo sapiens_hsa049160.60944338
82Vibrio cholerae infection_Homo sapiens_hsa051100.60012600
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58188539
84Pancreatic cancer_Homo sapiens_hsa052120.56313372
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55089238
86Long-term depression_Homo sapiens_hsa047300.55088566
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54869473
88HIF-1 signaling pathway_Homo sapiens_hsa040660.54523675
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53686356
90Estrogen signaling pathway_Homo sapiens_hsa049150.52303282
91p53 signaling pathway_Homo sapiens_hsa041150.50562363
92Basal transcription factors_Homo sapiens_hsa030220.50551306
93Viral carcinogenesis_Homo sapiens_hsa052030.50481225
94VEGF signaling pathway_Homo sapiens_hsa043700.49486605
95Oocyte meiosis_Homo sapiens_hsa041140.47648360
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46369482
97GnRH signaling pathway_Homo sapiens_hsa049120.46334870
98Rap1 signaling pathway_Homo sapiens_hsa040150.45449254
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45385558
100Endometrial cancer_Homo sapiens_hsa052130.45369813
101Nucleotide excision repair_Homo sapiens_hsa034200.44011341
102MAPK signaling pathway_Homo sapiens_hsa040100.43754605
103FoxO signaling pathway_Homo sapiens_hsa040680.43370937
104Axon guidance_Homo sapiens_hsa043600.42775850
105DNA replication_Homo sapiens_hsa030300.41652630
106ABC transporters_Homo sapiens_hsa020100.40734192
107Colorectal cancer_Homo sapiens_hsa052100.39797607
108Long-term potentiation_Homo sapiens_hsa047200.38614922
109Adherens junction_Homo sapiens_hsa045200.38313305
110Amphetamine addiction_Homo sapiens_hsa050310.37803629
111Rheumatoid arthritis_Homo sapiens_hsa053230.34286673
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32501542
113Choline metabolism in cancer_Homo sapiens_hsa052310.32358536
114Renal cell carcinoma_Homo sapiens_hsa052110.31093514
115Lysine degradation_Homo sapiens_hsa003100.31045678
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31003167
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30449413
118Gastric acid secretion_Homo sapiens_hsa049710.29767870
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.29143996
120ErbB signaling pathway_Homo sapiens_hsa040120.26299526
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25271285
122Pancreatic secretion_Homo sapiens_hsa049720.24630586
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24414616
124Retinol metabolism_Homo sapiens_hsa008300.24005933
125AMPK signaling pathway_Homo sapiens_hsa041520.23761369
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23267785
127Cocaine addiction_Homo sapiens_hsa050300.22688407
128Ras signaling pathway_Homo sapiens_hsa040140.20515873
129Carbon metabolism_Homo sapiens_hsa012000.20469833
130Fanconi anemia pathway_Homo sapiens_hsa034600.19978444
131RNA degradation_Homo sapiens_hsa030180.19172666
132Wnt signaling pathway_Homo sapiens_hsa043100.19078210
133Melanoma_Homo sapiens_hsa052180.18884078
134Purine metabolism_Homo sapiens_hsa002300.15794967
135Glucagon signaling pathway_Homo sapiens_hsa049220.14748885
136Systemic lupus erythematosus_Homo sapiens_hsa053220.14192935
137Glioma_Homo sapiens_hsa052140.13242340
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13057763
139Hippo signaling pathway_Homo sapiens_hsa043900.12567076
140Ovarian steroidogenesis_Homo sapiens_hsa049130.09409277
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.08839666
142Bile secretion_Homo sapiens_hsa049760.08637671
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.07449509

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