VTA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.00236250
2cullin deneddylation (GO:0010388)5.25675734
3protein deneddylation (GO:0000338)5.25104830
4NADH dehydrogenase complex assembly (GO:0010257)4.98552187
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.98552187
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.98552187
7chaperone-mediated protein transport (GO:0072321)4.91572773
8protein complex biogenesis (GO:0070271)4.72464624
9proteasome assembly (GO:0043248)4.53514261
10L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.52663771
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.35189981
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27737934
13ATP synthesis coupled proton transport (GO:0015986)4.27737934
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.23336591
15mitochondrial respiratory chain complex assembly (GO:0033108)4.11191286
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.89172069
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88770500
18chromatin remodeling at centromere (GO:0031055)3.86505045
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.85676319
20negative regulation of ligase activity (GO:0051352)3.85676319
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.81941400
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81604545
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.74999926
24central nervous system myelination (GO:0022010)3.67971588
25axon ensheathment in central nervous system (GO:0032291)3.67971588
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.66062843
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.66062843
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.62402467
29signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.62402467
30signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.62402467
31regulation of cellular amino acid metabolic process (GO:0006521)3.58390420
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.53412276
33DNA ligation (GO:0006266)3.52297002
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.49774924
35termination of RNA polymerase III transcription (GO:0006386)3.49774924
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.47880896
377-methylguanosine mRNA capping (GO:0006370)3.44674139
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.43673647
39signal transduction involved in DNA damage checkpoint (GO:0072422)3.43673647
40RNA capping (GO:0036260)3.41543316
417-methylguanosine RNA capping (GO:0009452)3.41543316
42histone exchange (GO:0043486)3.39991087
43positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35229576
44double-strand break repair via nonhomologous end joining (GO:0006303)3.34495798
45non-recombinational repair (GO:0000726)3.34495798
46respiratory electron transport chain (GO:0022904)3.34167445
47ribosome assembly (GO:0042255)3.34130109
48positive regulation of mitochondrial fission (GO:0090141)3.34007856
49antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.31361020
50positive regulation of ligase activity (GO:0051351)3.29572054
51electron transport chain (GO:0022900)3.26458247
52purine nucleobase biosynthetic process (GO:0009113)3.25706593
53signal peptide processing (GO:0006465)3.25643851
54maturation of 5.8S rRNA (GO:0000460)3.16012921
55mitotic metaphase plate congression (GO:0007080)3.12682406
56metaphase plate congression (GO:0051310)3.07709570
57amino acid salvage (GO:0043102)3.06689116
58L-methionine salvage (GO:0071267)3.06689116
59L-methionine biosynthetic process (GO:0071265)3.06689116
60regulation of mitochondrial translation (GO:0070129)3.02489718
61protein-cofactor linkage (GO:0018065)3.02105968
62respiratory chain complex IV assembly (GO:0008535)3.01959543
63protein targeting to mitochondrion (GO:0006626)3.01952682
64regulation of mitotic spindle checkpoint (GO:1903504)3.01329037
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01329037
66IMP biosynthetic process (GO:0006188)3.00711718
67replication fork processing (GO:0031297)3.00282460
68histone mRNA metabolic process (GO:0008334)2.99679882
69DNA catabolic process, exonucleolytic (GO:0000738)2.99512141
70DNA replication-independent nucleosome organization (GO:0034724)2.99317485
71DNA replication-independent nucleosome assembly (GO:0006336)2.99317485
72histone H2A acetylation (GO:0043968)2.96247713
73regulation of ubiquitin-protein transferase activity (GO:0051438)2.94122541
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93834498
75DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.93562674
76spliceosomal snRNP assembly (GO:0000387)2.93192003
77regulation of ligase activity (GO:0051340)2.91257996
78DNA replication-dependent nucleosome assembly (GO:0006335)2.90850492
79DNA replication-dependent nucleosome organization (GO:0034723)2.90850492
80postreplication repair (GO:0006301)2.90591537
81tRNA aminoacylation (GO:0043039)2.89385003
82amino acid activation (GO:0043038)2.89385003
83tRNA aminoacylation for protein translation (GO:0006418)2.86728460
84resolution of meiotic recombination intermediates (GO:0000712)2.86408118
85cytochrome complex assembly (GO:0017004)2.86375525
86spindle checkpoint (GO:0031577)2.85647875
87establishment of protein localization to mitochondrion (GO:0072655)2.85502354
88viral protein processing (GO:0019082)2.83942108
89nucleobase biosynthetic process (GO:0046112)2.83239836
90water-soluble vitamin biosynthetic process (GO:0042364)2.83178155
91DNA deamination (GO:0045006)2.81357571
92GTP biosynthetic process (GO:0006183)2.81296774
93mitotic spindle checkpoint (GO:0071174)2.80604033
94establishment of viral latency (GO:0019043)2.80593366
95viral mRNA export from host cell nucleus (GO:0046784)2.80238554
96mannosylation (GO:0097502)2.79750940
97transcription elongation from RNA polymerase II promoter (GO:0006368)2.78604578
98antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.77244063
99de novo posttranslational protein folding (GO:0051084)2.76441137
100positive regulation of cell cycle arrest (GO:0071158)2.74594201
101negative regulation of DNA-dependent DNA replication (GO:2000104)2.74504675
102regulation of cellular amine metabolic process (GO:0033238)2.74289592
103mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.73292756
104de novo protein folding (GO:0006458)2.70937770
105deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70602554
106sequestering of actin monomers (GO:0042989)2.70034024
107establishment of protein localization to mitochondrial membrane (GO:0090151)2.69733952
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68444054
109nucleotide-excision repair, DNA gap filling (GO:0006297)2.68416634
110regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68294019
111negative regulation of DNA recombination (GO:0045910)2.66992226
112DNA replication checkpoint (GO:0000076)2.66889559
113protein localization to mitochondrion (GO:0070585)2.66277043
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.66088168
115negative regulation of sister chromatid segregation (GO:0033046)2.66088168
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.66088168
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.66088168
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.66088168
119transcription-coupled nucleotide-excision repair (GO:0006283)2.64587143
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64474652
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64474652
122protein localization to kinetochore (GO:0034501)2.63791836
123telomere maintenance via semi-conservative replication (GO:0032201)2.62665289
124peptidyl-histidine modification (GO:0018202)2.61690630
125pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.60247807
126somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.59777884
127isotype switching (GO:0045190)2.59777884
128somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.59777884
129negative regulation of protein ubiquitination (GO:0031397)2.59519653
130platelet dense granule organization (GO:0060155)2.58747864
131establishment of integrated proviral latency (GO:0075713)2.57754434
132DNA double-strand break processing (GO:0000729)2.56483667
133protein K11-linked ubiquitination (GO:0070979)2.55786979
134CENP-A containing nucleosome assembly (GO:0034080)2.53878690
135rRNA modification (GO:0000154)2.48302556
136negative regulation of cell cycle G1/S phase transition (GO:1902807)2.46698217
137negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.46698217
138positive regulation of protein homodimerization activity (GO:0090073)2.46209029
139attachment of spindle microtubules to kinetochore (GO:0008608)2.44884915
140DNA damage response, detection of DNA damage (GO:0042769)2.44152338
141DNA-templated transcription, elongation (GO:0006354)2.43227476
142metallo-sulfur cluster assembly (GO:0031163)2.42230916
143iron-sulfur cluster assembly (GO:0016226)2.42230916
144GPI anchor biosynthetic process (GO:0006506)2.41868169
145positive regulation of protein ubiquitination (GO:0031398)2.41769413
146signal transduction in response to DNA damage (GO:0042770)2.40939766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.81977712
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.29666409
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.14310977
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.78803396
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.70097798
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08907479
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.04167080
8* ETS1_20019798_ChIP-Seq_JURKAT_Human2.99320343
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94431523
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82402281
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78940460
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.63518190
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.59613708
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.58378235
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52123472
16* VDR_23849224_ChIP-Seq_CD4+_Human2.37953794
17ZNF274_21170338_ChIP-Seq_K562_Hela2.36781877
18ELK1_19687146_ChIP-ChIP_HELA_Human2.30054555
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27061787
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19152773
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16949468
22DCP1A_22483619_ChIP-Seq_HELA_Human2.10486776
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.10219832
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06531774
25* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03402981
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00358052
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98774744
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96806418
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93433878
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80987299
31* GABP_19822575_ChIP-Seq_HepG2_Human1.74019553
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73990022
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73785441
34FOXP3_21729870_ChIP-Seq_TREG_Human1.71740020
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69767747
36VDR_22108803_ChIP-Seq_LS180_Human1.66076326
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.62569383
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60122945
39XRN2_22483619_ChIP-Seq_HELA_Human1.58562718
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.57984527
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50892013
42* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49402481
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48640105
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48604728
45* TTF2_22483619_ChIP-Seq_HELA_Human1.46568613
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45653812
47FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.44520385
48FUS_26573619_Chip-Seq_HEK293_Human1.41776717
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41357038
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41225737
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.41165343
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40520287
53AR_21909140_ChIP-Seq_LNCAP_Human1.40486943
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39731695
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38199256
56GBX2_23144817_ChIP-Seq_PC3_Human1.36398935
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34085466
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33186490
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32399697
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29819388
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.29726254
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27417384
63MYC_18940864_ChIP-ChIP_HL60_Human1.24858301
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24524691
65IRF1_19129219_ChIP-ChIP_H3396_Human1.23435085
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23012821
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22917824
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22743220
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21738420
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.21213603
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20538930
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20391642
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19814370
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19390525
75* EZH2_27294783_Chip-Seq_NPCs_Mouse1.16202714
76TAF15_26573619_Chip-Seq_HEK293_Human1.15119535
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14851719
78EWS_26573619_Chip-Seq_HEK293_Human1.14592175
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.12448486
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.12122628
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11136827
82* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11081141
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06751193
84IGF1R_20145208_ChIP-Seq_DFB_Human1.06513698
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.04709591
86CBP_20019798_ChIP-Seq_JUKART_Human1.04269934
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04269934
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.04208276
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03886745
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03777391
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03458098
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03004558
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02434064
94NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00840012
95RNF2_27304074_Chip-Seq_NSC_Mouse0.99294660
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98613411
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97677134
98* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94578149
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93752338
100TP53_22573176_ChIP-Seq_HFKS_Human0.93699288
101BP1_19119308_ChIP-ChIP_Hs578T_Human0.93219762
102CBX2_27304074_Chip-Seq_ESCs_Mouse0.92256695
103TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91990391
104* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91986047
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.91977991
106MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91969815
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91955107
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89955418
109ER_23166858_ChIP-Seq_MCF-7_Human0.88677958
110SOX2_16153702_ChIP-ChIP_HESCs_Human0.88061970
111SALL4_22934838_ChIP-ChIP_CD34+_Human0.87477459
112P300_19829295_ChIP-Seq_ESCs_Human0.86669803
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85218909
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84953724
115E2F7_22180533_ChIP-Seq_HELA_Human0.84765485
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.84723415
117TAL1_26923725_Chip-Seq_HPCs_Mouse0.82346006
118JUN_21703547_ChIP-Seq_K562_Human0.82038590
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81141081
120CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80874932
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79198744
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78734664
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77040854
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76897087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.91269608
2MP0001905_abnormal_dopamine_level2.88945654
3MP0006292_abnormal_olfactory_placode2.74262952
4MP0003880_abnormal_central_pattern2.74021538
5MP0003718_maternal_effect2.48156483
6MP0005171_absent_coat_pigmentation2.23538116
7MP0001984_abnormal_olfaction2.12897026
8MP0003136_yellow_coat_color2.12406587
9MP0008058_abnormal_DNA_repair1.86873912
10MP0005646_abnormal_pituitary_gland1.83849827
11MP0002736_abnormal_nociception_after1.81894723
12MP0008789_abnormal_olfactory_epithelium1.81726478
13MP0006276_abnormal_autonomic_nervous1.81316246
14MP0008932_abnormal_embryonic_tissue1.78967235
15MP0003186_abnormal_redox_activity1.77381961
16MP0008260_abnormal_autophagy1.73303101
17MP0003941_abnormal_skin_development1.72454850
18MP0002653_abnormal_ependyma_morphology1.70801100
19MP0002102_abnormal_ear_morphology1.70615813
20MP0006036_abnormal_mitochondrial_physio1.66906746
21MP0002163_abnormal_gland_morphology1.63469089
22MP0001986_abnormal_taste_sensitivity1.63451781
23MP0005645_abnormal_hypothalamus_physiol1.60665927
24MP0005253_abnormal_eye_physiology1.58848183
25MP0003693_abnormal_embryo_hatching1.58785708
26MP0006035_abnormal_mitochondrial_morpho1.53063405
27MP0002822_catalepsy1.50343305
28MP0003195_calcinosis1.49352541
29MP0002277_abnormal_respiratory_mucosa1.48296612
30MP0001293_anophthalmia1.47730495
31MP0002751_abnormal_autonomic_nervous1.47006103
32MP0000372_irregular_coat_pigmentation1.46968135
33MP0009697_abnormal_copulation1.46050672
34MP0010094_abnormal_chromosome_stability1.45974657
35MP0001188_hyperpigmentation1.43907827
36MP0005671_abnormal_response_to1.43905046
37MP0000516_abnormal_urinary_system1.43676082
38MP0005367_renal/urinary_system_phenotyp1.43676082
39MP0002132_abnormal_respiratory_system1.42529451
40MP0008007_abnormal_cellular_replicative1.41925192
41MP0004142_abnormal_muscle_tone1.40588793
42MP0005499_abnormal_olfactory_system1.39233941
43MP0005394_taste/olfaction_phenotype1.39233941
44MP0004957_abnormal_blastocyst_morpholog1.38561766
45MP0003077_abnormal_cell_cycle1.38260038
46MP0001968_abnormal_touch/_nociception1.37405757
47MP0005075_abnormal_melanosome_morpholog1.37373047
48MP0005084_abnormal_gallbladder_morpholo1.36631954
49MP0004215_abnormal_myocardial_fiber1.34949931
50MP0002837_dystrophic_cardiac_calcinosis1.34661789
51MP0002938_white_spotting1.32188914
52MP0000778_abnormal_nervous_system1.31588816
53MP0001764_abnormal_homeostasis1.31454907
54MP0002734_abnormal_mechanical_nocicepti1.30906525
55MP0005187_abnormal_penis_morphology1.30455911
56MP0005551_abnormal_eye_electrophysiolog1.30326579
57MP0000920_abnormal_myelination1.29903637
58MP0002234_abnormal_pharynx_morphology1.29772873
59MP0002090_abnormal_vision1.28843512
60MP0005408_hypopigmentation1.28288083
61MP0004742_abnormal_vestibular_system1.28183935
62MP0003567_abnormal_fetal_cardiomyocyte1.27236455
63MP0000566_synostosis1.26184574
64MP0002148_abnormal_hypersensitivity_rea1.25837806
65MP0001485_abnormal_pinna_reflex1.23247545
66MP0000647_abnormal_sebaceous_gland1.22847204
67MP0002638_abnormal_pupillary_reflex1.20294992
68MP0010386_abnormal_urinary_bladder1.19650071
69MP0009785_altered_susceptibility_to1.19240262
70MP0004147_increased_porphyrin_level1.18541664
71MP0003121_genomic_imprinting1.16273263
72MP0001970_abnormal_pain_threshold1.14906209
73MP0003724_increased_susceptibility_to1.12621168
74MP0003937_abnormal_limbs/digits/tail_de1.11825883
75MP0004270_analgesia1.11012989
76MP0009379_abnormal_foot_pigmentation1.08637892
77MP0005451_abnormal_body_composition1.07754927
78MP0002272_abnormal_nervous_system1.05730719
79MP0003806_abnormal_nucleotide_metabolis1.04626320
80MP0001835_abnormal_antigen_presentation1.04264275
81MP0009333_abnormal_splenocyte_physiolog1.04141599
82MP0004924_abnormal_behavior1.03054157
83MP0005386_behavior/neurological_phenoty1.03054157
84MP0000015_abnormal_ear_pigmentation1.02822654
85MP0001929_abnormal_gametogenesis1.02587640
86MP0003122_maternal_imprinting1.02511352
87MP0000026_abnormal_inner_ear1.01025404
88MP0005423_abnormal_somatic_nervous1.00740380
89MP0002233_abnormal_nose_morphology1.00655480
90MP0002064_seizures1.00144467
91MP0002735_abnormal_chemical_nociception0.99527289
92MP0001486_abnormal_startle_reflex0.98405951
93MP0003787_abnormal_imprinting0.97884045
94MP0000631_abnormal_neuroendocrine_gland0.97358840
95MP0003890_abnormal_embryonic-extraembry0.95639944
96MP0002184_abnormal_innervation0.95597731
97MP0005379_endocrine/exocrine_gland_phen0.94945260
98MP0002733_abnormal_thermal_nociception0.93348177
99MP0001346_abnormal_lacrimal_gland0.93060719
100MP0000358_abnormal_cell_content/0.92765734
101MP0003011_delayed_dark_adaptation0.92432383
102MP0002160_abnormal_reproductive_system0.91885318
103MP0002210_abnormal_sex_determination0.91730402
104MP0002067_abnormal_sensory_capabilities0.91389727
105MP0008877_abnormal_DNA_methylation0.89979916
106MP0002572_abnormal_emotion/affect_behav0.89836757
107MP0003221_abnormal_cardiomyocyte_apopto0.89640968
108MP0003315_abnormal_perineum_morphology0.88824337
109MP0009745_abnormal_behavioral_response0.88820366
110MP0005248_abnormal_Harderian_gland0.87225570
111MP0000653_abnormal_sex_gland0.86656378
112MP0001963_abnormal_hearing_physiology0.86141810
113MP0000569_abnormal_digit_pigmentation0.86036785
114MP0000049_abnormal_middle_ear0.86005811
115MP0005000_abnormal_immune_tolerance0.85409955
116MP0002557_abnormal_social/conspecific_i0.85375290
117MP0001177_atelectasis0.84142288
118MP0002282_abnormal_trachea_morphology0.82892860
119MP0000427_abnormal_hair_cycle0.82213998
120MP0001145_abnormal_male_reproductive0.82067561
121MP0003119_abnormal_digestive_system0.81230866
122MP0002063_abnormal_learning/memory/cond0.80524579
123MP0003938_abnormal_ear_development0.79856690
124MP0001324_abnormal_eye_pigmentation0.78825189
125MP0005389_reproductive_system_phenotype0.77958959
126MP0003634_abnormal_glial_cell0.77304180
127MP0002095_abnormal_skin_pigmentation0.77112502
128MP0003755_abnormal_palate_morphology0.76416690
129MP0005391_vision/eye_phenotype0.75954140
130MP0006072_abnormal_retinal_apoptosis0.75312540
131MP0009046_muscle_twitch0.75007881
132MP0003698_abnormal_male_reproductive0.74683302
133MP0003656_abnormal_erythrocyte_physiolo0.74601811
134MP0005395_other_phenotype0.74302531
135MP0001286_abnormal_eye_development0.74205887
136MP0003635_abnormal_synaptic_transmissio0.74127340
137MP0003950_abnormal_plasma_membrane0.73917732
138MP0006082_CNS_inflammation0.72989311
139MP0002752_abnormal_somatic_nervous0.72139782
140MP0004134_abnormal_chest_morphology0.71056674
141MP0002882_abnormal_neuron_morphology0.70730717
142MP0003786_premature_aging0.70201426
143MP0004133_heterotaxia0.69607106
144MP0003646_muscle_fatigue0.69300486
145MP0001119_abnormal_female_reproductive0.67835889
146MP0003111_abnormal_nucleus_morphology0.66977597
147MP0008057_abnormal_DNA_replication0.66952796

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.66063427
2Abnormal mitochondria in muscle tissue (HP:0008316)5.10606677
3Mitochondrial inheritance (HP:0001427)4.76223800
4Progressive macrocephaly (HP:0004481)4.54240681
5Acute encephalopathy (HP:0006846)4.23949342
6Hepatocellular necrosis (HP:0001404)4.20978396
7Increased CSF lactate (HP:0002490)4.08263227
8Increased serum pyruvate (HP:0003542)4.06825413
9Abnormality of glycolysis (HP:0004366)4.06825413
10Methylmalonic acidemia (HP:0002912)3.77783356
11Cerebral hypomyelination (HP:0006808)3.29537448
12Hepatic necrosis (HP:0002605)3.24411012
13Renal Fanconi syndrome (HP:0001994)3.21238402
14Increased hepatocellular lipid droplets (HP:0006565)3.17867440
153-Methylglutaconic aciduria (HP:0003535)3.15337829
16Leukodystrophy (HP:0002415)3.15130955
17Hyperglycinemia (HP:0002154)2.95750922
18Medial flaring of the eyebrow (HP:0010747)2.91402155
19Respiratory failure (HP:0002878)2.89231761
20Nephrogenic diabetes insipidus (HP:0009806)2.87567010
21Birth length less than 3rd percentile (HP:0003561)2.86053635
22Methylmalonic aciduria (HP:0012120)2.84893873
23Abnormal hair whorl (HP:0010721)2.80197028
24Increased serum lactate (HP:0002151)2.77725455
25Gait imbalance (HP:0002141)2.77330834
26Congenital primary aphakia (HP:0007707)2.74853004
27Optic disc pallor (HP:0000543)2.73142622
28Exercise intolerance (HP:0003546)2.71850913
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71339846
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71178461
31Type I transferrin isoform profile (HP:0003642)2.70470843
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63203735
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63203735
34Volvulus (HP:0002580)2.62926303
35Neuroendocrine neoplasm (HP:0100634)2.57186482
36Pancreatic fibrosis (HP:0100732)2.57124686
37True hermaphroditism (HP:0010459)2.56784306
38Exertional dyspnea (HP:0002875)2.53032104
39Lipid accumulation in hepatocytes (HP:0006561)2.51651990
40Abnormality of methionine metabolism (HP:0010901)2.49712892
41Lactic acidosis (HP:0003128)2.46270338
42Abnormality of serum amino acid levels (HP:0003112)2.45831027
43Type 2 muscle fiber atrophy (HP:0003554)2.45602047
44Colon cancer (HP:0003003)2.44559797
45Parakeratosis (HP:0001036)2.38308333
46Renal cortical cysts (HP:0000803)2.38045205
47Abnormality of the vitamin B12 metabolism (HP:0004341)2.37511871
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.35569363
49Pancreatic cysts (HP:0001737)2.32627196
50Abnormality of renal resorption (HP:0011038)2.31882703
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.30747999
52Abnormality of vitamin B metabolism (HP:0004340)2.29748529
53Meckel diverticulum (HP:0002245)2.26827383
54Short tibia (HP:0005736)2.24553702
55Atrophy/Degeneration involving motor neurons (HP:0007373)2.24332113
56Abnormality of placental membranes (HP:0011409)2.23847128
57Amniotic constriction ring (HP:0009775)2.23847128
58Respiratory difficulties (HP:0002880)2.22297093
59Abnormality of chromosome stability (HP:0003220)2.21950294
60Genital tract atresia (HP:0001827)2.21730877
61Pheochromocytoma (HP:0002666)2.20768777
62Vaginal atresia (HP:0000148)2.20598003
63Abnormality of the ileum (HP:0001549)2.16271008
64Abnormal lung lobation (HP:0002101)2.16135594
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.14325868
66Hypothermia (HP:0002045)2.12497247
67Muscle fiber atrophy (HP:0100295)2.12037878
68Megaloblastic anemia (HP:0001889)2.08574134
69Cerebral edema (HP:0002181)2.06090854
70Abnormality of glycine metabolism (HP:0010895)2.05845614
71Abnormality of serine family amino acid metabolism (HP:0010894)2.05845614
72Hypoplastic pelvis (HP:0008839)2.04735859
73Increased intramyocellular lipid droplets (HP:0012240)2.04245148
74Adrenal hypoplasia (HP:0000835)2.04005634
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03589776
76CNS hypomyelination (HP:0003429)2.02274262
77Molar tooth sign on MRI (HP:0002419)2.01600303
78Abnormality of midbrain morphology (HP:0002418)2.01600303
79Breast hypoplasia (HP:0003187)1.99178857
80Poor coordination (HP:0002370)1.97824228
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95959757
82Abnormal protein N-linked glycosylation (HP:0012347)1.95959757
83Abnormal protein glycosylation (HP:0012346)1.95959757
84Abnormal glycosylation (HP:0012345)1.95959757
85Poor head control (HP:0002421)1.95164335
86Retinal dysplasia (HP:0007973)1.95068974
87Degeneration of the lateral corticospinal tracts (HP:0002314)1.95055652
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95055652
89Lissencephaly (HP:0001339)1.94100959
90CNS demyelination (HP:0007305)1.93433305
91Nephronophthisis (HP:0000090)1.92756966
92Aplasia/Hypoplasia of the lens (HP:0008063)1.90068527
93X-linked dominant inheritance (HP:0001423)1.89683759
94Broad foot (HP:0001769)1.88939312
95Lethargy (HP:0001254)1.88862496
96Aplastic anemia (HP:0001915)1.88357832
97Chromsome breakage (HP:0040012)1.86727854
98Absent septum pellucidum (HP:0001331)1.85245165
99Gonadotropin excess (HP:0000837)1.84839626
100Postnatal microcephaly (HP:0005484)1.84787552
101Neoplasm of the adrenal gland (HP:0100631)1.84523600
102Abnormality of alanine metabolism (HP:0010916)1.84011117
103Hyperalaninemia (HP:0003348)1.84011117
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84011117
105Tubulointerstitial nephritis (HP:0001970)1.83998784
106Esotropia (HP:0000565)1.81692584
107Ependymoma (HP:0002888)1.80087426
108Split foot (HP:0001839)1.80028874
109Duodenal stenosis (HP:0100867)1.79604622
110Small intestinal stenosis (HP:0012848)1.79604622
111Sloping forehead (HP:0000340)1.78593849
112Emotional lability (HP:0000712)1.78366085
113Abnormality of the septum pellucidum (HP:0007375)1.78255768
114Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74907479
115Patellar aplasia (HP:0006443)1.74434272
116Amyotrophic lateral sclerosis (HP:0007354)1.73693657
117Abnormality of the preputium (HP:0100587)1.73679629
118Sclerocornea (HP:0000647)1.73038351
119Aplasia/hypoplasia of the uterus (HP:0008684)1.73027257
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.72925049
121Cortical dysplasia (HP:0002539)1.72535665
122Poor suck (HP:0002033)1.71444046
123Hypoplasia of the fovea (HP:0007750)1.71427947
124Aplasia/Hypoplasia of the fovea (HP:0008060)1.71427947
125Abnormality of the labia minora (HP:0012880)1.70452408
126Progressive inability to walk (HP:0002505)1.70436220
127Irregular epiphyses (HP:0010582)1.70011868
128Anencephaly (HP:0002323)1.68935557
129Bifid tongue (HP:0010297)1.68887766
130Aplasia/Hypoplasia of the sternum (HP:0006714)1.68195634
131Morphological abnormality of the inner ear (HP:0011390)1.67573312
132Hypoplastic left heart (HP:0004383)1.67077728
133Decreased testicular size (HP:0008734)1.66422792
134Glioma (HP:0009733)1.66128804
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.65869812
136Astrocytoma (HP:0009592)1.65281946
137Abnormality of the astrocytes (HP:0100707)1.65281946
138Posterior subcapsular cataract (HP:0007787)1.65183761
139Microvesicular hepatic steatosis (HP:0001414)1.61989563
140Patchy hypopigmentation of hair (HP:0011365)1.61306882
141Abnormality of the anterior horn cell (HP:0006802)1.60522706
142Degeneration of anterior horn cells (HP:0002398)1.60522706
143Preaxial hand polydactyly (HP:0001177)1.59337981
144Autoamputation (HP:0001218)1.58417437
145Limb dystonia (HP:0002451)1.57287618
146Hypoplastic heart (HP:0001961)1.57087751
147Increased IgM level (HP:0003496)1.56599061
148Aplasia/Hypoplasia of the patella (HP:0006498)1.55543620
149Aganglionic megacolon (HP:0002251)1.52544088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.63043627
2CASK3.56970208
3TRIM283.14019443
4MAP3K123.09924140
5PBK2.70791435
6MAP4K22.69479505
7STK162.48710249
8LIMK12.41083732
9BMPR1B2.38665134
10TESK22.35311890
11MUSK2.19533727
12CDK192.16095533
13MAP2K72.13510957
14DYRK22.11227627
15MST42.08992971
16EIF2AK12.08140974
17ACVR1B2.07279954
18CCNB11.87915373
19VRK11.84414039
20BMPR21.78248000
21PLK41.75128697
22VRK21.72919984
23BRAF1.71302441
24NME11.67899812
25BCR1.64025521
26SIK31.58217552
27ARAF1.57650037
28EIF2AK31.54693343
29CSNK1G21.50480650
30ADRBK21.48175937
31TESK11.45604645
32CSNK1A1L1.37122789
33SRPK11.34798522
34MAPK131.29686242
35PLK21.27294908
36CDK81.26335156
37MAPKAPK51.24928345
38PIM21.19423561
39FRK1.16080582
40YES11.15074986
41MARK11.13759060
42NME21.11568586
43MOS1.08863160
44MKNK11.06162138
45OXSR11.05783883
46TXK1.03749011
47PNCK1.00023194
48AKT30.99513807
49MINK10.98465479
50PINK10.97969252
51GRK70.96355007
52TSSK60.94776145
53BCKDK0.91000367
54MYLK0.90558461
55ERBB40.89897970
56IRAK40.88367641
57STK390.86914969
58INSRR0.85531284
59PLK30.85311648
60TNIK0.84919664
61PRPF4B0.81859957
62TLK10.81706389
63EPHA40.79452510
64AURKA0.78732683
65GRK10.78405787
66CLK10.77351838
67KDR0.75177665
68ATR0.75167516
69STK38L0.73725894
70PDK20.73610240
71CDC70.72855693
72MAP3K60.71442168
73WNK30.71197398
74CSNK1G30.70538642
75RPS6KA40.70270100
76SGK4940.67023214
77SGK2230.67023214
78ADRBK10.66277315
79MAP3K40.65962713
80CAMK2B0.64380697
81PAK30.61648566
82PRKCG0.60894365
83ATM0.60332343
84ERBB30.59218555
85PLK10.59010445
86DYRK30.55776221
87NEK10.55311976
88WEE10.53456666
89ZAK0.52273112
90ROCK20.51321304
91RPS6KA50.50189900
92CDK180.50037938
93UHMK10.49633059
94CHEK20.48930436
95TAF10.48900522
96GRK50.47200411
97EIF2AK20.46188319
98CAMK2A0.46091251
99BLK0.45607304
100OBSCN0.45302874
101MKNK20.44107084
102TGFBR10.43804476
103NEK60.43208530
104CDK140.43134207
105DAPK10.42228825
106PAK10.41646643
107FER0.41359857
108CDK11A0.40130937
109CSNK1G10.40021364
110CDK150.39646160
111PRKCE0.39351682
112CSNK2A10.39323556
113CDK30.39068596
114CSNK2A20.38517206
115FGFR10.38232868
116PASK0.37951133
117ILK0.37823338
118MAP3K50.37563369
119STK30.36968343
120CAMK2D0.36630405
121NTRK20.36371580
122BRSK10.36347643
123NUAK10.35672192
124PRKCI0.35140821
125RAF10.34725776
126FGR0.34446406
127BRSK20.33521363
128CSNK1E0.32623240
129CSNK1A10.32167171
130PKN10.31891314
131CSNK1D0.31475265
132CHEK10.31461930
133AURKB0.30994959
134PHKG10.30987133
135PHKG20.30987133
136TTK0.30829451
137NEK20.29438800

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.53945191
2Oxidative phosphorylation_Homo sapiens_hsa001903.86883144
3Protein export_Homo sapiens_hsa030603.26997197
4Parkinsons disease_Homo sapiens_hsa050123.24057158
5RNA polymerase_Homo sapiens_hsa030203.02968910
6Ribosome_Homo sapiens_hsa030102.48415019
7Huntingtons disease_Homo sapiens_hsa050162.38609071
8Propanoate metabolism_Homo sapiens_hsa006402.35581098
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.32245709
10Alzheimers disease_Homo sapiens_hsa050102.30508235
11Mismatch repair_Homo sapiens_hsa034302.21594569
12DNA replication_Homo sapiens_hsa030302.06601761
13Basal transcription factors_Homo sapiens_hsa030221.95206173
14Homologous recombination_Homo sapiens_hsa034401.85370947
15Nucleotide excision repair_Homo sapiens_hsa034201.81790385
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78100970
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73094898
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70376003
19Collecting duct acid secretion_Homo sapiens_hsa049661.69162796
20Pyrimidine metabolism_Homo sapiens_hsa002401.68469254
21Spliceosome_Homo sapiens_hsa030401.67276137
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66400050
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65291767
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63825337
25Base excision repair_Homo sapiens_hsa034101.62898959
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59762764
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53852965
28Butanoate metabolism_Homo sapiens_hsa006501.46542443
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43564674
30Vibrio cholerae infection_Homo sapiens_hsa051101.41558762
31Pyruvate metabolism_Homo sapiens_hsa006201.40406750
32Cell cycle_Homo sapiens_hsa041101.39709427
33RNA degradation_Homo sapiens_hsa030181.39377801
34Rheumatoid arthritis_Homo sapiens_hsa053231.38828912
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37972436
36Graft-versus-host disease_Homo sapiens_hsa053321.29209553
37RNA transport_Homo sapiens_hsa030131.26651567
38Ether lipid metabolism_Homo sapiens_hsa005651.23075155
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20819209
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20660691
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17949099
42Allograft rejection_Homo sapiens_hsa053301.14075113
43Steroid biosynthesis_Homo sapiens_hsa001001.12130275
44Non-homologous end-joining_Homo sapiens_hsa034501.11524357
45Selenocompound metabolism_Homo sapiens_hsa004501.08075416
46Purine metabolism_Homo sapiens_hsa002301.03914882
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99960163
48Fanconi anemia pathway_Homo sapiens_hsa034600.98809249
49Peroxisome_Homo sapiens_hsa041460.97262799
50Phagosome_Homo sapiens_hsa041450.97199659
51Type I diabetes mellitus_Homo sapiens_hsa049400.95767673
52Carbon metabolism_Homo sapiens_hsa012000.94412552
53Sphingolipid metabolism_Homo sapiens_hsa006000.87680269
54Fatty acid elongation_Homo sapiens_hsa000620.87237915
55Autoimmune thyroid disease_Homo sapiens_hsa053200.85714433
56Cardiac muscle contraction_Homo sapiens_hsa042600.83969519
57Epstein-Barr virus infection_Homo sapiens_hsa051690.83897153
58Sulfur metabolism_Homo sapiens_hsa009200.80724380
59Serotonergic synapse_Homo sapiens_hsa047260.80266552
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80058753
61Asthma_Homo sapiens_hsa053100.78626097
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78609603
63Fatty acid metabolism_Homo sapiens_hsa012120.77422111
64Synaptic vesicle cycle_Homo sapiens_hsa047210.77086324
65Biosynthesis of amino acids_Homo sapiens_hsa012300.73268991
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73039951
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71784247
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71569875
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68486148
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67895740
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.66651430
72Caffeine metabolism_Homo sapiens_hsa002320.66376383
73Shigellosis_Homo sapiens_hsa051310.59781193
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.59697929
75Arachidonic acid metabolism_Homo sapiens_hsa005900.59551863
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58098460
77Nitrogen metabolism_Homo sapiens_hsa009100.57929006
78Other glycan degradation_Homo sapiens_hsa005110.57823549
79Regulation of autophagy_Homo sapiens_hsa041400.57711367
80beta-Alanine metabolism_Homo sapiens_hsa004100.57373593
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56379103
82Nicotine addiction_Homo sapiens_hsa050330.55536868
83Glutathione metabolism_Homo sapiens_hsa004800.55039288
84Legionellosis_Homo sapiens_hsa051340.54776822
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54616286
86Tryptophan metabolism_Homo sapiens_hsa003800.53977914
87Oocyte meiosis_Homo sapiens_hsa041140.52500526
88Arginine and proline metabolism_Homo sapiens_hsa003300.51265482
89Vitamin digestion and absorption_Homo sapiens_hsa049770.50252119
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49089075
91Malaria_Homo sapiens_hsa051440.48282776
92Primary immunodeficiency_Homo sapiens_hsa053400.46256100
93p53 signaling pathway_Homo sapiens_hsa041150.45849231
94Fatty acid degradation_Homo sapiens_hsa000710.45714691
95Metabolic pathways_Homo sapiens_hsa011000.45652673
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43919143
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43838118
98Alcoholism_Homo sapiens_hsa050340.43556390
99Hematopoietic cell lineage_Homo sapiens_hsa046400.42029953
100Linoleic acid metabolism_Homo sapiens_hsa005910.41391977
101Vitamin B6 metabolism_Homo sapiens_hsa007500.40551684
102mRNA surveillance pathway_Homo sapiens_hsa030150.40415049
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39523999
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37990478
105Pertussis_Homo sapiens_hsa051330.36920493
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35924771
107Folate biosynthesis_Homo sapiens_hsa007900.35588687
108Chemical carcinogenesis_Homo sapiens_hsa052040.34909224
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34763167
110Phototransduction_Homo sapiens_hsa047440.34479312
111Herpes simplex infection_Homo sapiens_hsa051680.33620472
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32636452
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.30133653
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29613792
115Retinol metabolism_Homo sapiens_hsa008300.29546099
116Measles_Homo sapiens_hsa051620.29210415
117Colorectal cancer_Homo sapiens_hsa052100.29000462
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.28988510
119African trypanosomiasis_Homo sapiens_hsa051430.28732668
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28192455
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28114507
122Salmonella infection_Homo sapiens_hsa051320.27325988
123GABAergic synapse_Homo sapiens_hsa047270.25469385
124Morphine addiction_Homo sapiens_hsa050320.24913712
125Olfactory transduction_Homo sapiens_hsa047400.23663681
126Fat digestion and absorption_Homo sapiens_hsa049750.23528668
127N-Glycan biosynthesis_Homo sapiens_hsa005100.23488826
128Sulfur relay system_Homo sapiens_hsa041220.23176820
129Taste transduction_Homo sapiens_hsa047420.22784235
130TGF-beta signaling pathway_Homo sapiens_hsa043500.22544047
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21788766
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21207443
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.20832929
134Dopaminergic synapse_Homo sapiens_hsa047280.20571507
135One carbon pool by folate_Homo sapiens_hsa006700.20541669
136Circadian rhythm_Homo sapiens_hsa047100.20228247
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.20158757
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18563614
139Antigen processing and presentation_Homo sapiens_hsa046120.17968703

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