VTCN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte development (GO:0003334)6.90164370
2terpenoid biosynthetic process (GO:0016114)5.61565075
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.42931465
4nephron tubule formation (GO:0072079)5.41031338
5ear development (GO:0043583)5.40422793
6glomerular visceral epithelial cell development (GO:0072015)5.25218668
7negative regulation of keratinocyte proliferation (GO:0010839)5.21261585
8hemidesmosome assembly (GO:0031581)5.12136250
9lung lobe morphogenesis (GO:0060463)4.98980472
10glomerular epithelial cell development (GO:0072310)4.84639343
11regulation of cardioblast differentiation (GO:0051890)4.78790032
12cornea development in camera-type eye (GO:0061303)4.77707223
13keratinocyte proliferation (GO:0043616)4.71708650
14glomerular basement membrane development (GO:0032836)4.39564019
15artery smooth muscle contraction (GO:0014824)4.36417074
16wound healing, spreading of epidermal cells (GO:0035313)4.29820845
17intestinal epithelial cell development (GO:0060576)4.28200546
18macrophage chemotaxis (GO:0048246)4.24657331
19regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.19203207
20lung vasculature development (GO:0060426)4.13432406
21lung-associated mesenchyme development (GO:0060484)3.99131144
22negative regulation of kidney development (GO:0090185)3.97327543
23primary alcohol catabolic process (GO:0034310)3.96689117
24folic acid transport (GO:0015884)3.96449635
25tonic smooth muscle contraction (GO:0014820)3.93884348
26cysteine metabolic process (GO:0006534)3.91683807
27regulation of apoptotic process involved in morphogenesis (GO:1902337)3.90694650
28desmosome organization (GO:0002934)3.89772915
29skin morphogenesis (GO:0043589)3.88542676
30regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.87701624
31regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.85868040
32transepithelial transport (GO:0070633)3.83894835
33regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.81564545
34regulation of water loss via skin (GO:0033561)3.80398210
35negative regulation of T cell differentiation in thymus (GO:0033085)3.76494502
36transcytosis (GO:0045056)3.75964483
37axonemal dynein complex assembly (GO:0070286)3.75797286
38epithelial cell differentiation involved in prostate gland development (GO:0060742)3.75285103
39negative regulation of metanephros development (GO:0072217)3.71494271
40lung epithelium development (GO:0060428)3.67768881
41diterpenoid biosynthetic process (GO:0016102)3.67142850
42sulfur amino acid catabolic process (GO:0000098)3.66142381
43galactose catabolic process (GO:0019388)3.66090054
44regulation of cell proliferation involved in kidney development (GO:1901722)3.61837775
45positive regulation of osteoblast proliferation (GO:0033690)3.61815914
46regulation of complement activation (GO:0030449)3.59086273
47regulation of protein activation cascade (GO:2000257)3.57659093
48inositol phosphate-mediated signaling (GO:0048016)3.57594871
49regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.53189599
50endocrine process (GO:0050886)3.53189599
51regulation of systemic arterial blood pressure by hormone (GO:0001990)3.53189599
52epithelial cell-cell adhesion (GO:0090136)3.51573424
53energy homeostasis (GO:0097009)3.49477694
54positive regulation of odontogenesis (GO:0042482)3.47212085
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.46831548
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.46432216
57pattern specification involved in kidney development (GO:0061004)3.44800903
58galactose metabolic process (GO:0006012)3.42989251
59negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.40815557
60wound healing, spreading of cells (GO:0044319)3.40775429
61branching involved in labyrinthine layer morphogenesis (GO:0060670)3.39547040
62keratan sulfate catabolic process (GO:0042340)3.39002415
63negative regulation of cell fate specification (GO:0009996)3.36423404
64regulation of keratinocyte proliferation (GO:0010837)3.35814653
65prostaglandin biosynthetic process (GO:0001516)3.34348890
66prostanoid biosynthetic process (GO:0046457)3.34348890
67gap junction assembly (GO:0016264)3.31951689
68complement activation, alternative pathway (GO:0006957)3.31818795
69branching involved in salivary gland morphogenesis (GO:0060445)3.31540427
70cell adhesion mediated by integrin (GO:0033627)3.30753961
71tight junction assembly (GO:0070830)3.29193824
72regulation of neuron projection regeneration (GO:0070570)3.28771413
73regulation of axon regeneration (GO:0048679)3.28771413
74L-ascorbic acid metabolic process (GO:0019852)3.27755201
75regulation of transforming growth factor beta1 production (GO:0032908)3.27501354
76mesodermal cell differentiation (GO:0048333)3.24834747
77positive regulation of pseudopodium assembly (GO:0031274)3.24694927
78mesonephros development (GO:0001823)3.23726872
79retinoic acid metabolic process (GO:0042573)3.22006245
80* interferon-gamma secretion (GO:0072643)3.21100900
81lateral sprouting from an epithelium (GO:0060601)3.16325963
82citrulline biosynthetic process (GO:0019240)3.14176259
83dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.14001711
84negative regulation of neurological system process (GO:0031645)3.13155055
85asymmetric protein localization (GO:0008105)3.13017030
86amino-acid betaine metabolic process (GO:0006577)3.12956052
87oocyte development (GO:0048599)3.12091229
88establishment of planar polarity (GO:0001736)3.11818139
89establishment of tissue polarity (GO:0007164)3.11818139
90embryonic heart tube development (GO:0035050)3.11817336
91ethanol oxidation (GO:0006069)3.11149423
92apical protein localization (GO:0045176)3.10605379
93nonribosomal peptide biosynthetic process (GO:0019184)3.10317240
944-hydroxyproline metabolic process (GO:0019471)3.07837592
95COPI coating of Golgi vesicle (GO:0048205)3.07230568
96Golgi transport vesicle coating (GO:0048200)3.07230568
97norepinephrine metabolic process (GO:0042415)3.06376671
98cilium movement (GO:0003341)3.06255918
99cilium or flagellum-dependent cell motility (GO:0001539)3.05798714
100establishment of skin barrier (GO:0061436)3.04485186
101glutathione biosynthetic process (GO:0006750)3.04292463
102branching involved in mammary gland duct morphogenesis (GO:0060444)3.04193859
103hepatocyte apoptotic process (GO:0097284)3.04164863
104calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.03301059
105cell-cell junction assembly (GO:0007043)3.03166940
106negative regulation of transcription by competitive promoter binding (GO:0010944)3.03143355
107ruffle organization (GO:0031529)3.02507751
108face development (GO:0060324)3.01313190
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.00794843
110L-phenylalanine metabolic process (GO:0006558)3.00794843
111folic acid metabolic process (GO:0046655)2.99822239
112glutathione derivative biosynthetic process (GO:1901687)2.97430342
113glutathione derivative metabolic process (GO:1901685)2.97430342
114embryonic cranial skeleton morphogenesis (GO:0048701)2.96155766
115erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.94777764
116L-phenylalanine catabolic process (GO:0006559)2.94777764
117hepatocyte differentiation (GO:0070365)2.94388456
118kynurenine metabolic process (GO:0070189)2.93469312
119positive regulation of heart rate (GO:0010460)2.92692748
120morphogenesis of embryonic epithelium (GO:0016331)2.92404382
121regulation of transforming growth factor beta2 production (GO:0032909)2.91916150
122regulation of glomerulus development (GO:0090192)2.90529052
123xenobiotic catabolic process (GO:0042178)2.89106872
124epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88718601
125epithelial cilium movement (GO:0003351)2.87725041
126vitamin transmembrane transport (GO:0035461)2.87455581
127establishment of apical/basal cell polarity (GO:0035089)2.85466626
128regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.85348705
129vascular smooth muscle contraction (GO:0014829)2.85299631
130retinal metabolic process (GO:0042574)2.84195241
131pyrimidine-containing compound transmembrane transport (GO:0072531)2.83636416
132hypotonic response (GO:0006971)2.82939610
133regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.82795790
134lens fiber cell development (GO:0070307)2.81925410
135ethanol metabolic process (GO:0006067)2.81835553
136regulation of glomerular filtration (GO:0003093)2.81742470
137positive regulation of actin filament depolymerization (GO:0030836)2.80682627
138regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.80140513
139labyrinthine layer development (GO:0060711)2.79738025
140response to interferon-beta (GO:0035456)2.79517844
141regulation of pseudopodium assembly (GO:0031272)2.79324094
142modified amino acid transport (GO:0072337)2.76638504
143multicellular organismal water homeostasis (GO:0050891)2.76270562
144aromatic amino acid family catabolic process (GO:0009074)2.75912288
145embryonic camera-type eye development (GO:0031076)2.75858136
146regulation of cell fate specification (GO:0042659)2.75765565
147regulation of integrin-mediated signaling pathway (GO:2001044)2.75475536
148type B pancreatic cell proliferation (GO:0044342)2.74680868
149hormone catabolic process (GO:0042447)2.74530148
150apoptotic cell clearance (GO:0043277)2.73746070
151mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.72877539
152positive regulation of glomerulus development (GO:0090193)2.72347508
153urea cycle (GO:0000050)2.72046465
154urea metabolic process (GO:0019627)2.72046465
155water homeostasis (GO:0030104)2.71474330
156positive regulation of catenin import into nucleus (GO:0035413)2.70916232
157establishment or maintenance of apical/basal cell polarity (GO:0035088)2.70484611
158regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.68773247
159tryptophan catabolic process (GO:0006569)2.68453671
160indole-containing compound catabolic process (GO:0042436)2.68453671
161indolalkylamine catabolic process (GO:0046218)2.68453671
162hippo signaling (GO:0035329)2.68352092
163surfactant homeostasis (GO:0043129)2.68342162
164negative regulation of protein activation cascade (GO:2000258)2.68215963
165positive regulation of p38MAPK cascade (GO:1900745)2.67986882
166serine family amino acid catabolic process (GO:0009071)2.62641163
167growth hormone receptor signaling pathway (GO:0060396)2.62161907
168heme transport (GO:0015886)2.62019820
169fibrinolysis (GO:0042730)2.60453618
170regulation of cholesterol homeostasis (GO:2000188)2.60436084
171protein carboxylation (GO:0018214)2.59397241
172peptidyl-glutamic acid carboxylation (GO:0017187)2.59397241
173regulation of alkaline phosphatase activity (GO:0010692)2.59325977
174regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.57948070
175iron coordination entity transport (GO:1901678)2.57453507
176negative regulation of complement activation (GO:0045916)2.55973409
177alpha-linolenic acid metabolic process (GO:0036109)2.55603903
178atrioventricular valve morphogenesis (GO:0003181)2.55228216
179regulation of hippo signaling (GO:0035330)2.55210893
180vitamin transport (GO:0051180)2.53929950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.56934664
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.54518120
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.74901955
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.94141139
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.78132188
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.60732060
7* ESR2_21235772_ChIP-Seq_MCF-7_Human3.42743329
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.31991794
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.25557592
10* ESR1_21235772_ChIP-Seq_MCF-7_Human3.19812088
11ZNF263_19887448_ChIP-Seq_K562_Human3.13996475
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.10127039
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06080498
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.90806044
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.86704054
16CLOCK_20551151_ChIP-Seq_293T_Human2.71031387
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.69895468
18SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.50114712
19SOX2_27498859_Chip-Seq_STOMACH_Mouse2.33546825
20* FOXM1_26456572_ChIP-Seq_MCF-7_Human2.31850180
21PPAR_26484153_Chip-Seq_NCI-H1993_Human2.30080356
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28328927
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27610402
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.23256360
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.16195729
26FOXO3_23340844_ChIP-Seq_DLD1_Human2.15673533
27GATA4_25053715_ChIP-Seq_YYC3_Human2.12944491
28ARNT_22903824_ChIP-Seq_MCF-7_Human2.12817015
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.12484744
30EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11383613
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.09287247
32CDX2_20551321_ChIP-Seq_CACO-2_Human2.08556626
33AR_21909140_ChIP-Seq_LNCAP_Human2.02976023
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.00838622
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.95884194
36SOX2_20726797_ChIP-Seq_SW620_Human1.91228180
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90170618
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.90133752
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.90133752
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89388764
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.88520797
42* ELF5_23300383_ChIP-Seq_T47D_Human1.84448099
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80822620
44GATA6_25053715_ChIP-Seq_YYC3_Human1.72516119
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71083263
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68120502
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67681775
48ATF3_27146783_Chip-Seq_COLON_Human1.63082944
49EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.60744679
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58961157
51RACK7_27058665_Chip-Seq_MCF-7_Human1.56108826
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55225334
53* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54630445
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50470254
55* GATA3_24758297_ChIP-Seq_MCF-7_Human1.49606110
56* RUNX1_27514584_Chip-Seq_MCF-7_Human1.47158720
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46962342
58* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46494842
59TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45779475
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43725803
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42754060
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42059487
63* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33067478
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.32482687
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32038032
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30511376
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27677488
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.26041399
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.21141457
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19030517
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16692729
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15442694
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15289424
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13769417
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.12776209
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12304450
77AHR_22903824_ChIP-Seq_MCF-7_Human1.10171575
78TP63_23658742_ChIP-Seq_EP156T_Human1.09748653
79FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06623418
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05423876
81KLF5_25053715_ChIP-Seq_YYC3_Human1.04821692
82FOXA1_25552417_ChIP-Seq_VCAP_Human1.04350163
83CJUN_26792858_Chip-Seq_BT549_Human1.01373997
84NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99965751
85* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99305955
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97523662
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95758133
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95752727
89GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95633720
90UBF1/2_26484160_Chip-Seq_HMECs_Human0.95619235
91OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94638802
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.94518793
93SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92275450
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91770389
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91635103
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.90852666
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.89093081
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88902553
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88800291
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87716094
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87582991
102CHD1_26751641_Chip-Seq_LNCaP_Human0.86566451
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84777360
104HNF4A_19822575_ChIP-Seq_HepG2_Human0.84340337
105ERG_21242973_ChIP-ChIP_JURKAT_Human0.82813312
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81748615
107P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81084054
108FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80610431
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79928943
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79811297
111TP53_18474530_ChIP-ChIP_U2OS_Human0.79279379
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77019377
113CREB1_26743006_Chip-Seq_LNCaP_Human0.76124466
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75631140
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75631140
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.75410119
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.72606743
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.72606743
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.72606743
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.72460459
121TDRD3_21172665_ChIP-Seq_MCF-7_Human0.69379291
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.69054799
123HOXB7_26014856_ChIP-Seq_BT474_Human0.67707403
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.66845284
125EOMES_21245162_ChIP-Seq_HESCs_Human0.66446406
126PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.66053252
127TP63_22573176_ChIP-Seq_HFKS_Human0.65626225
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65415058
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64818920
130P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.61462218
131* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.59029788
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.58795956
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.58618462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.73233290
2MP0002254_reproductive_system_inflammat4.53932517
3MP0002139_abnormal_hepatobiliary_system3.60818857
4MP0010386_abnormal_urinary_bladder3.21303883
5MP0009780_abnormal_chondrocyte_physiolo3.20908359
6MP0005377_hearing/vestibular/ear_phenot2.81306424
7MP0003878_abnormal_ear_physiology2.81306424
8MP0004264_abnormal_extraembryonic_tissu2.72251242
9MP0005085_abnormal_gallbladder_physiolo2.63574884
10MP0008875_abnormal_xenobiotic_pharmacok2.44591709
11MP0005365_abnormal_bile_salt2.43822166
12MP0004019_abnormal_vitamin_homeostasis2.40362972
13MP0010678_abnormal_skin_adnexa2.36426373
14MP0000537_abnormal_urethra_morphology2.35458040
15MP0003566_abnormal_cell_adhesion2.34008857
16MP0004272_abnormal_basement_membrane2.25083139
17MP0009840_abnormal_foam_cell2.20308977
18MP0002138_abnormal_hepatobiliary_system2.16303704
19MP0001881_abnormal_mammary_gland2.14501132
20MP0003183_abnormal_peptide_metabolism2.14326285
21MP0005360_urolithiasis2.14157479
22MP0001666_abnormal_nutrient_absorption2.07757982
23MP0005083_abnormal_biliary_tract2.06766653
24MP0002796_impaired_skin_barrier2.04379916
25MP0003705_abnormal_hypodermis_morpholog2.01270168
26MP0005248_abnormal_Harderian_gland1.98331362
27MP0010352_gastrointestinal_tract_polyps1.84223775
28MP0003806_abnormal_nucleotide_metabolis1.79686338
29MP0002098_abnormal_vibrissa_morphology1.76216262
30MP0000383_abnormal_hair_follicle1.73557969
31MP0003300_gastrointestinal_ulcer1.68875789
32MP0000566_synostosis1.67313249
33MP0010329_abnormal_lipoprotein_level1.66516725
34MP0003950_abnormal_plasma_membrane1.66380861
35MP0001346_abnormal_lacrimal_gland1.64833495
36MP0005332_abnormal_amino_acid1.63876635
37MP0003938_abnormal_ear_development1.61225336
38MP0004133_heterotaxia1.60045732
39MP0003252_abnormal_bile_duct1.57038683
40MP0000627_abnormal_mammary_gland1.56330191
41MP0004381_abnormal_hair_follicle1.54990712
42MP0009643_abnormal_urine_homeostasis1.52938693
43MP0006054_spinal_hemorrhage1.42436714
44MP0001661_extended_life_span1.41943682
45MP0003453_abnormal_keratinocyte_physiol1.41923827
46MP0003879_abnormal_hair_cell1.39763055
47MP0009384_cardiac_valve_regurgitation1.38508497
48MP0005023_abnormal_wound_healing1.35985225
49MP0001216_abnormal_epidermal_layer1.34102645
50MP0002132_abnormal_respiratory_system1.33321811
51MP0009053_abnormal_anal_canal1.33125662
52MP0001849_ear_inflammation1.32542117
53MP0001756_abnormal_urination1.28578319
54MP0000377_abnormal_hair_follicle1.26430539
55MP0000579_abnormal_nail_morphology1.25700739
56MP0005275_abnormal_skin_tensile1.24780870
57MP0005501_abnormal_skin_physiology1.23291290
58MP0002060_abnormal_skin_morphology1.22617899
59MP0005646_abnormal_pituitary_gland1.22399549
60MP0002876_abnormal_thyroid_physiology1.19829568
61MP0002653_abnormal_ependyma_morphology1.15359432
62MP0002136_abnormal_kidney_physiology1.14400868
63MP0010368_abnormal_lymphatic_system1.12565362
64MP0003693_abnormal_embryo_hatching1.11140053
65MP0000762_abnormal_tongue_morphology1.10769163
66MP0000609_abnormal_liver_physiology1.08676720
67MP0002168_other_aberrant_phenotype1.07087613
68MP0003195_calcinosis1.03435791
69MP0002277_abnormal_respiratory_mucosa1.02853921
70MP0005319_abnormal_enzyme/_coenzyme1.01937515
71MP0004782_abnormal_surfactant_physiolog1.01401488
72MP0002295_abnormal_pulmonary_circulatio0.99511732
73MP0005503_abnormal_tendon_morphology0.99162185
74MP0004883_abnormal_blood_vessel0.98327568
75MP0003638_abnormal_response/metabolism_0.97953081
76MP0003941_abnormal_skin_development0.97256527
77MP0001958_emphysema0.96987377
78MP0002118_abnormal_lipid_homeostasis0.96851680
79MP0005395_other_phenotype0.95694123
80MP0000462_abnormal_digestive_system0.95279156
81MP0000647_abnormal_sebaceous_gland0.93939793
82MP0005451_abnormal_body_composition0.92647446
83MP0003045_fibrosis0.91775481
84MP0002896_abnormal_bone_mineralization0.91687399
85MP0003936_abnormal_reproductive_system0.91537504
86MP0000681_abnormal_thyroid_gland0.91476650
87MP0001485_abnormal_pinna_reflex0.91269144
88MP0003119_abnormal_digestive_system0.91235784
89MP0005058_abnormal_lysosome_morphology0.91134111
90MP0003186_abnormal_redox_activity0.89483065
91MP0003191_abnormal_cellular_cholesterol0.87310442
92MP0002233_abnormal_nose_morphology0.86214931
93MP0002089_abnormal_postnatal_growth/wei0.86029291
94MP0002108_abnormal_muscle_morphology0.85883733
95MP0002282_abnormal_trachea_morphology0.84558716
96MP0005164_abnormal_response_to0.83046263
97MP0000467_abnormal_esophagus_morphology0.82725558
98MP0002135_abnormal_kidney_morphology0.82458322
99MP0010030_abnormal_orbit_morphology0.81936885
100MP0001765_abnormal_ion_homeostasis0.79979104
101MP0000427_abnormal_hair_cycle0.79888305
102MP0003115_abnormal_respiratory_system0.79560897
103MP0000639_abnormal_adrenal_gland0.79461711
104MP0005636_abnormal_mineral_homeostasis0.78104228
105MP0004084_abnormal_cardiac_muscle0.77113730
106MP0004185_abnormal_adipocyte_glucose0.76381665
107MP0005257_abnormal_intraocular_pressure0.74518611
108MP0005166_decreased_susceptibility_to0.74361224
109MP0000604_amyloidosis0.73729167
110MP0005408_hypopigmentation0.73164136
111MP0005623_abnormal_meninges_morphology0.72943825
112MP0010771_integument_phenotype0.71823974
113MP0000477_abnormal_intestine_morphology0.71782391
114MP0004957_abnormal_blastocyst_morpholog0.70998357
115MP0000367_abnormal_coat/_hair0.70081682
116MP0002086_abnormal_extraembryonic_tissu0.69916089
117MP0004947_skin_inflammation0.69549470
118MP0001542_abnormal_bone_strength0.69479991
119MP0005187_abnormal_penis_morphology0.69180354
120MP0003329_amyloid_beta_deposits0.69087421
121MP0003718_maternal_effect0.68262008
122MP0008789_abnormal_olfactory_epithelium0.67447588
123MP0005076_abnormal_cell_differentiation0.66567225
124MP0000858_altered_metastatic_potential0.65797045
125MP0000598_abnormal_liver_morphology0.64077328
126MP0009931_abnormal_skin_appearance0.61988156
127MP0005075_abnormal_melanosome_morpholog0.61834470
128MP0003136_yellow_coat_color0.61449142
129MP0002928_abnormal_bile_duct0.60621727
130MP0004043_abnormal_pH_regulation0.58672872
131MP0005220_abnormal_exocrine_pancreas0.57973435
132MP0001340_abnormal_eyelid_morphology0.57431835
133MP0000613_abnormal_salivary_gland0.57428419
134MP0008872_abnormal_physiological_respon0.57361482
135MP0003943_abnormal_hepatobiliary_system0.56725369
136MP0002116_abnormal_craniofacial_bone0.56493299
137MP0002160_abnormal_reproductive_system0.55737204
138MP0001177_atelectasis0.52681327

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.20937819
2Focal segmental glomerulosclerosis (HP:0000097)5.12043208
3Lip pit (HP:0100267)4.78745929
4Glomerulosclerosis (HP:0000096)4.59572251
5Onycholysis (HP:0001806)4.53709259
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.19460178
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.06096251
8Gout (HP:0001997)4.05609480
9Deep venous thrombosis (HP:0002625)3.89650073
10Fragile nails (HP:0001808)3.82847062
11Morphological abnormality of the middle ear (HP:0008609)3.74270798
12Cervical subluxation (HP:0003308)3.69617403
13Vacuolated lymphocytes (HP:0001922)3.68221973
14Pili torti (HP:0003777)3.62044397
15Intrahepatic cholestasis (HP:0001406)3.60749691
16Alopecia of scalp (HP:0002293)3.56155682
17Esophageal varix (HP:0002040)3.55047686
18Concave nail (HP:0001598)3.52276001
19Mesangial abnormality (HP:0001966)3.41551990
20Xanthomatosis (HP:0000991)3.33226910
21Atrophic scars (HP:0001075)3.30378582
22Milia (HP:0001056)3.25839217
23Chronic bronchitis (HP:0004469)3.24093162
24Rhinitis (HP:0012384)3.23303134
25Abnormal respiratory motile cilium physiology (HP:0012261)3.12602865
26Nephritis (HP:0000123)3.11439422
27Hyperlipoproteinemia (HP:0010980)3.03395589
28Bicornuate uterus (HP:0000813)3.00645460
29Bell-shaped thorax (HP:0001591)2.98873783
30Vascular calcification (HP:0004934)2.97203284
31Abnormality of the distal phalanges of the toes (HP:0010182)2.95312497
32Hypoalbuminemia (HP:0003073)2.95168508
33Abnormal albumin level (HP:0012116)2.95168508
34Hypoalphalipoproteinemia (HP:0003233)2.85474063
35Abnormal ciliary motility (HP:0012262)2.82333668
36Abnormal respiratory motile cilium morphology (HP:0005938)2.82309134
37Abnormal respiratory epithelium morphology (HP:0012253)2.82309134
38Abnormal pancreas size (HP:0012094)2.80098763
39Severe Myopia (HP:0011003)2.79075384
40Cardiovascular calcification (HP:0011915)2.78862072
41Taurodontia (HP:0000679)2.78543635
42Abnormality of permanent molar morphology (HP:0011071)2.78543635
43Abnormality of the dental root (HP:0006486)2.78543635
44Micronodular cirrhosis (HP:0001413)2.77844389
45Proximal tubulopathy (HP:0000114)2.77372328
46Ileus (HP:0002595)2.76189591
47Glomerulonephritis (HP:0000099)2.74185700
48Short nail (HP:0001799)2.73603535
49Abnormality of the proximal phalanges of the hand (HP:0009834)2.68667244
50Polycythemia (HP:0001901)2.65978337
51Ventricular tachycardia (HP:0004756)2.65733694
52Premature rupture of membranes (HP:0001788)2.61261920
53Abnormality of molar morphology (HP:0011070)2.60636536
54Abnormality of molar (HP:0011077)2.60636536
55Absent eyebrow (HP:0002223)2.59881749
56Flat acetabular roof (HP:0003180)2.57540442
57Plantar hyperkeratosis (HP:0007556)2.57147134
58Absent/shortened dynein arms (HP:0200106)2.56786015
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.56786015
60Hypolipoproteinemia (HP:0010981)2.56522033
61Abnormality of the dental pulp (HP:0006479)2.56471482
62Complement deficiency (HP:0004431)2.55598292
63Pustule (HP:0200039)2.55154821
64Male infertility (HP:0003251)2.53262363
65Bronchomalacia (HP:0002780)2.51384126
66Abnormality of aromatic amino acid family metabolism (HP:0004338)2.51141159
67Abnormality of the nasal septum (HP:0000419)2.50539641
68Bronchiectasis (HP:0002110)2.49941265
69Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.48069876
70Abnormality of dental color (HP:0011073)2.46185068
71Hyperactive renin-angiotensin system (HP:0000841)2.45038983
72Rectal prolapse (HP:0002035)2.44773430
73Amelogenesis imperfecta (HP:0000705)2.43768437
74Myocardial infarction (HP:0001658)2.42948884
75Thyroid-stimulating hormone excess (HP:0002925)2.42306969
76Abnormality of the lacrimal duct (HP:0011481)2.42193772
77Renal tubular acidosis (HP:0001947)2.41379041
78Tubulointerstitial fibrosis (HP:0005576)2.40051134
79Interstitial pulmonary disease (HP:0006530)2.39788400
80Hypobetalipoproteinemia (HP:0003563)2.39569487
81Abnormal hemoglobin (HP:0011902)2.38323303
82Absent eyelashes (HP:0000561)2.38102854
83Osteolytic defects of the hand bones (HP:0009699)2.35179471
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.35179471
85Hypotrichosis (HP:0001006)2.34576050
86Abdominal distention (HP:0003270)2.32995579
87Nail dystrophy (HP:0008404)2.31352352
88Curly hair (HP:0002212)2.30441289
89Abnormality of the labia majora (HP:0012881)2.29242213
90Glucose intolerance (HP:0000833)2.28242712
91Abnormality of purine metabolism (HP:0004352)2.27801881
92Biliary tract neoplasm (HP:0100574)2.27435819
93Increased purine levels (HP:0004368)2.27258923
94Hyperuricemia (HP:0002149)2.27258923
95Pterygium (HP:0001059)2.26960177
96Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.24956511
97Hyperammonemia (HP:0001987)2.24889083
98Disproportionate short-trunk short stature (HP:0003521)2.23885263
99Cone-rod dystrophy (HP:0000548)2.20883087
100Fat malabsorption (HP:0002630)2.20617004
101Abnormal hair laboratory examination (HP:0003328)2.18813322
102Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.18255518
103Vertebral hypoplasia (HP:0008417)2.18255518
104Hyperglycinuria (HP:0003108)2.18050379
105Spastic diplegia (HP:0001264)2.17053574
106Popliteal pterygium (HP:0009756)2.13290571
107Hypoplasia of the uterus (HP:0000013)2.13115418
108Aplasia cutis congenita (HP:0001057)2.12751534
109Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12583985
110Renal salt wasting (HP:0000127)2.12148754
111Sparse lateral eyebrow (HP:0005338)2.10498580
112Hyperglycinemia (HP:0002154)2.09397366
113Sparse eyelashes (HP:0000653)2.08224603
114Microglossia (HP:0000171)2.07262458
115Humeroradial synostosis (HP:0003041)2.06604299
116Synostosis involving the elbow (HP:0003938)2.06604299
117Woolly hair (HP:0002224)2.05836655
118Abnormality of the nasolacrimal system (HP:0000614)2.04954332
119Malnutrition (HP:0004395)2.04088036
120Hyperglycemia (HP:0003074)2.03073791
121Hypoplasia of the iris (HP:0007676)2.02809721
122Abnormality of glycine metabolism (HP:0010895)2.01334538
123Abnormality of serine family amino acid metabolism (HP:0010894)2.01334538
124Infertility (HP:0000789)2.01265445
125Tongue fasciculations (HP:0001308)2.00129070
126Hypoplasia of the odontoid process (HP:0003311)1.97146041
127Ulnar bowing (HP:0003031)1.96624179
128Stridor (HP:0010307)1.94845647
129Advanced eruption of teeth (HP:0006288)1.94672952
130Abnormal blistering of the skin (HP:0008066)1.94581104
131Beaking of vertebral bodies (HP:0004568)1.94382610
132Choanal stenosis (HP:0000452)1.93020390
133Steatorrhea (HP:0002570)1.92807270
134Corneal erosion (HP:0200020)1.92078640
135Hypoplastic labia majora (HP:0000059)1.91563826
136Hemorrhage of the eye (HP:0011885)1.90513575
137Hypoplasia of dental enamel (HP:0006297)1.90280448
138Abnormality of the middle phalanges of the toes (HP:0010183)1.88336739
139Broad nasal tip (HP:0000455)1.87205962
140Aplasia/hypoplasia of the uterus (HP:0008684)1.87097353
141Stenosis of the external auditory canal (HP:0000402)1.86395114
142Wide intermamillary distance (HP:0006610)1.85980015
143Abnormality of fatty-acid metabolism (HP:0004359)1.85708376
144Abnormal tarsal ossification (HP:0008369)1.85348924
145Germ cell neoplasia (HP:0100728)1.84888046
146Ankle contracture (HP:0006466)1.84344613
147Tubulointerstitial nephritis (HP:0001970)1.84001213
148Abnormality of nucleobase metabolism (HP:0010932)1.83932483
149Abnormality of the common coagulation pathway (HP:0010990)1.83209870
150Ulnar deviation of the wrist (HP:0003049)1.83193026
151Nasolacrimal duct obstruction (HP:0000579)1.82898912
152Flattened epiphyses (HP:0003071)1.82423162
153Back pain (HP:0003418)1.82296252
154Tubular atrophy (HP:0000092)1.82222455
155Abnormality of nail color (HP:0100643)1.82115546
156Stomach cancer (HP:0012126)1.81360159
157Bifid tongue (HP:0010297)1.81316984
158Congenital ichthyosiform erythroderma (HP:0007431)1.81231775
159Cutaneous finger syndactyly (HP:0010554)1.81053013
160Abnormality of complement system (HP:0005339)1.80846652
161Abnormality of sulfur amino acid metabolism (HP:0004339)1.80623936
162Trismus (HP:0000211)1.79160273
163Abnormal biliary tract morphology (HP:0012440)1.77936128
164Abnormality of macular pigmentation (HP:0008002)1.77594513
165Ureteral duplication (HP:0000073)1.77432893
166Congenital, generalized hypertrichosis (HP:0004540)1.77359889
167Flat capital femoral epiphysis (HP:0003370)1.76872081
168Shallow orbits (HP:0000586)1.76674253
169Abnormalities of placenta or umbilical cord (HP:0001194)1.76589233
170Acanthosis nigricans (HP:0000956)1.76166728
171Abnormality of the pubic bones (HP:0003172)1.74869953
172Natal tooth (HP:0000695)1.74534960
173Abnormality of chloride homeostasis (HP:0011422)1.73838811
174Renal tubular dysfunction (HP:0000124)1.73428584
175Abnormality of the umbilical cord (HP:0010881)1.71725625
176Median cleft lip (HP:0000161)1.71463931
177Posterior subcapsular cataract (HP:0007787)1.71295685
178Severe short stature (HP:0003510)1.70572093
179Fibular aplasia (HP:0002990)1.69951465
180Abnormal cartilage morphology (HP:0002763)1.68824455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST42.57204124
2OXSR12.50868562
3FER2.40556546
4MST1R2.35458461
5LATS12.34653855
6SIK32.29963012
7MAP3K32.25224725
8TRIM282.17338986
9EPHB22.15228037
10EPHB12.12825100
11PAK42.05190985
12SIK12.04334544
13TRIB32.01991483
14EPHA210.3277745
15RPS6KB21.96096863
16FGFR41.88881196
17NEK91.73925025
18EPHA31.65023155
19MAP3K21.62970930
20PTK21.61512082
21FRK1.51107587
22CDK121.49853198
23PDK31.49253060
24PDK41.49253060
25PDK21.46306679
26PTK61.46147988
27MET1.39037021
28STK38L1.37858689
29MAP2K21.36798737
30TESK11.17402641
31NLK1.17073240
32PNCK1.11132549
33LIMK11.09946373
34NEK61.06161297
35ERN11.05494116
36BCKDK1.04977625
37MUSK1.04120170
38MYLK1.01758385
39GRK11.01307132
40STK391.01022628
41WEE10.96677077
42LRRK20.93695431
43RIPK10.92955435
44STK30.89165603
45ERBB20.88286999
46NME10.88061156
47FGFR20.86884938
48LMTK20.86729343
49TNIK0.86501069
50BMPR1B0.86420961
51MAP2K10.85748028
52TGFBR20.80235867
53PRKCI0.79165632
54CDK60.78918534
55DMPK0.78637712
56WNK40.77045709
57MAP2K60.76717681
58PIK3CA0.76150189
59PLK40.74384422
60AKT30.71975570
61BRSK20.71521740
62EIF2AK10.66219927
63PKN20.65441391
64TRPM70.64833659
65CHUK0.62892129
66ZAP700.62799676
67STK240.62729959
68MAPKAPK30.61709467
69PRKG20.61434134
70PRKD10.60865462
71CSNK1G10.60298941
72NME20.60267779
73FGFR10.58021186
74TAOK10.57992072
75STK100.57250415
76LATS20.54629099
77PAK30.52759542
78BMX0.52338229
79PRKCE0.51647437
80STK380.50716158
81GSK3A0.50017409
82ERBB30.49764774
83MAP3K110.49534244
84BUB10.48659468
85MAP3K120.46972626
86NUAK10.46569294
87MTOR0.45277295
88TBK10.44005232
89NEK10.43590881
90MAP2K30.42994253
91MAPK150.41615183
92ROCK10.41343110
93TLK10.39600376
94MAP3K10.38655330
95JAK10.38526488
96ROCK20.38169001
97TGFBR10.38094159
98DAPK20.37650467
99FGFR30.37196762
100BCR0.35217538
101RPS6KA40.34879362
102ILK0.34670340
103MAP3K80.34628148
104CDK70.34585077
105PAK20.33923939
106PAK10.33811257
107KDR0.33464828
108ACVR1B0.32797445
109CSNK1A10.31173700
110DDR20.31155007
111MAP3K60.30808702
112PDGFRB0.29313055
113TTN0.29269052
114PDGFRA0.29103156
115EIF2AK30.28842485
116PDPK10.28638311
117ABL20.27582559
118PIM20.27248659
119ERBB40.26974765
120IGF1R0.26775676
121MATK0.26628983
122IRAK10.26143527
123SGK30.25731451
124MELK0.25202736
125MAP3K70.25195234
126MINK10.25017746
127SCYL20.24664904
128CSNK1E0.24240287
129RET0.24011828
130CSNK1A1L0.23977968
131AURKB0.23766709
132PRKCD0.22723166
133CAMK2G0.22698250
134DYRK1B0.22310259
135EGFR0.22257985
136STK160.20674328
137ABL10.20240704
138MAPKAPK20.20169254
139IKBKB0.19556365
140PRKD20.19030312
141MAPKAPK50.18382717
142NTRK10.18186079

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.07484608
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.89374392
3Other glycan degradation_Homo sapiens_hsa005112.87754400
4Nitrogen metabolism_Homo sapiens_hsa009102.63339230
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.56571240
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.55673723
7Histidine metabolism_Homo sapiens_hsa003402.53525423
8Sphingolipid metabolism_Homo sapiens_hsa006002.50761211
9Chemical carcinogenesis_Homo sapiens_hsa052042.44389567
10Caffeine metabolism_Homo sapiens_hsa002322.39775338
11beta-Alanine metabolism_Homo sapiens_hsa004102.14553540
12Complement and coagulation cascades_Homo sapiens_hsa046102.09450226
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06301866
14Vibrio cholerae infection_Homo sapiens_hsa051102.00995289
15Arginine biosynthesis_Homo sapiens_hsa002201.95423125
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93061888
17Glutathione metabolism_Homo sapiens_hsa004801.89058731
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87258397
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83627235
20ECM-receptor interaction_Homo sapiens_hsa045121.81340974
21Fatty acid degradation_Homo sapiens_hsa000711.73878131
22Phenylalanine metabolism_Homo sapiens_hsa003601.73554224
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72708911
24Fatty acid elongation_Homo sapiens_hsa000621.70449680
25Tight junction_Homo sapiens_hsa045301.62571991
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62001071
27Ovarian steroidogenesis_Homo sapiens_hsa049131.60990543
28Retinol metabolism_Homo sapiens_hsa008301.60724191
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58833710
30Vitamin B6 metabolism_Homo sapiens_hsa007501.55798987
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52027777
32Adherens junction_Homo sapiens_hsa045201.48128106
33Fat digestion and absorption_Homo sapiens_hsa049751.44172568
34Tryptophan metabolism_Homo sapiens_hsa003801.40567409
35PPAR signaling pathway_Homo sapiens_hsa033201.38728342
36Collecting duct acid secretion_Homo sapiens_hsa049661.38594087
37Vitamin digestion and absorption_Homo sapiens_hsa049771.35241942
38Hippo signaling pathway_Homo sapiens_hsa043901.30885559
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26653101
40N-Glycan biosynthesis_Homo sapiens_hsa005101.25539685
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23460023
42Small cell lung cancer_Homo sapiens_hsa052221.22864475
43Tyrosine metabolism_Homo sapiens_hsa003501.22452199
44Sulfur metabolism_Homo sapiens_hsa009201.20609234
45Proteasome_Homo sapiens_hsa030501.19898054
46Peroxisome_Homo sapiens_hsa041461.18888613
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18442411
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18132434
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17750110
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17420024
51Propanoate metabolism_Homo sapiens_hsa006401.17344180
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15439805
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.10656330
54Pentose phosphate pathway_Homo sapiens_hsa000301.09045864
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08859974
56Mineral absorption_Homo sapiens_hsa049781.08812482
57Selenocompound metabolism_Homo sapiens_hsa004501.08631669
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.08366395
59Bladder cancer_Homo sapiens_hsa052191.07269237
60Proteoglycans in cancer_Homo sapiens_hsa052051.03730470
61Amoebiasis_Homo sapiens_hsa051461.02898967
62Renin-angiotensin system_Homo sapiens_hsa046141.01054232
63Bile secretion_Homo sapiens_hsa049761.00844122
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.99328846
65Fatty acid metabolism_Homo sapiens_hsa012120.98522544
66Folate biosynthesis_Homo sapiens_hsa007900.97930753
67Sulfur relay system_Homo sapiens_hsa041220.97719960
68Focal adhesion_Homo sapiens_hsa045100.94402293
69Steroid biosynthesis_Homo sapiens_hsa001000.92754796
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91761685
71Carbon metabolism_Homo sapiens_hsa012000.90723429
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.90720508
73Circadian rhythm_Homo sapiens_hsa047100.87779525
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84223749
75Butanoate metabolism_Homo sapiens_hsa006500.84169890
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83780636
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83126299
78Staphylococcus aureus infection_Homo sapiens_hsa051500.81048272
79Endometrial cancer_Homo sapiens_hsa052130.78795155
80Pancreatic secretion_Homo sapiens_hsa049720.78496322
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75999946
82Biosynthesis of amino acids_Homo sapiens_hsa012300.74969920
83ABC transporters_Homo sapiens_hsa020100.74670857
84Glycerolipid metabolism_Homo sapiens_hsa005610.73263969
85Arginine and proline metabolism_Homo sapiens_hsa003300.71437355
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70023320
87Fructose and mannose metabolism_Homo sapiens_hsa000510.69999449
88Arachidonic acid metabolism_Homo sapiens_hsa005900.68015291
89Starch and sucrose metabolism_Homo sapiens_hsa005000.65453890
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65269096
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65255748
92Basal cell carcinoma_Homo sapiens_hsa052170.61811233
93Phototransduction_Homo sapiens_hsa047440.61437535
94Endocytosis_Homo sapiens_hsa041440.60730485
95Thyroid cancer_Homo sapiens_hsa052160.60612170
96Pyruvate metabolism_Homo sapiens_hsa006200.59072276
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58969339
98Linoleic acid metabolism_Homo sapiens_hsa005910.57422032
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56938862
100Galactose metabolism_Homo sapiens_hsa000520.56678463
101Prostate cancer_Homo sapiens_hsa052150.56157167
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56007850
103Regulation of autophagy_Homo sapiens_hsa041400.54526147
104Protein digestion and absorption_Homo sapiens_hsa049740.53501137
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53374015
106Hedgehog signaling pathway_Homo sapiens_hsa043400.52860874
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.52702993
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51420195
109Lysosome_Homo sapiens_hsa041420.50884027
110p53 signaling pathway_Homo sapiens_hsa041150.50875119
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50700363
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50318254
113Insulin resistance_Homo sapiens_hsa049310.50067590
114* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46264891
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.45920538
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45160463
117Thyroid hormone synthesis_Homo sapiens_hsa049180.42766960
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41863723
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41271410
120Metabolic pathways_Homo sapiens_hsa011000.41053236
121Axon guidance_Homo sapiens_hsa043600.40289868
122Renal cell carcinoma_Homo sapiens_hsa052110.39684201
123Hepatitis C_Homo sapiens_hsa051600.38933454
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36885212
125Toxoplasmosis_Homo sapiens_hsa051450.35651436
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.35602482
127Fatty acid biosynthesis_Homo sapiens_hsa000610.34061450
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.33864366
129Wnt signaling pathway_Homo sapiens_hsa043100.32689698
130TGF-beta signaling pathway_Homo sapiens_hsa043500.31453279
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.31449649
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31021822
133Melanogenesis_Homo sapiens_hsa049160.24233652
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21719623
135Prolactin signaling pathway_Homo sapiens_hsa049170.16798437
136Nicotine addiction_Homo sapiens_hsa050330.14388665
137Huntingtons disease_Homo sapiens_hsa050160.13427179

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