VTI1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fucose catabolic process (GO:0019317)6.36447099
2L-fucose metabolic process (GO:0042354)6.36447099
3L-fucose catabolic process (GO:0042355)6.36447099
4protein prenylation (GO:0018342)6.23686620
5prenylation (GO:0097354)6.23686620
6synaptic vesicle maturation (GO:0016188)5.81869269
7negative regulation of T cell receptor signaling pathway (GO:0050860)4.94734542
8positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.84962139
9positive regulation of mitotic sister chromatid separation (GO:1901970)4.84962139
10positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.84962139
11locomotory exploration behavior (GO:0035641)4.73051779
12negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.55673900
13protein K11-linked deubiquitination (GO:0035871)4.52532552
14sodium ion export (GO:0071436)4.49152799
15autophagic vacuole fusion (GO:0000046)4.40225038
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.37532283
17synaptic vesicle exocytosis (GO:0016079)4.31536265
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.24182314
19regulation of T cell receptor signaling pathway (GO:0050856)4.19972484
20glutamate secretion (GO:0014047)4.19294983
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14672427
22eosinophil chemotaxis (GO:0048245)4.12333963
23organelle membrane fusion (GO:0090174)4.11456458
24activated T cell proliferation (GO:0050798)3.97592317
25cellular potassium ion homeostasis (GO:0030007)3.95381056
26regulation of synaptic vesicle exocytosis (GO:2000300)3.92696805
27negative regulation of Ras GTPase activity (GO:0034261)3.89761309
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.84991328
29indolalkylamine metabolic process (GO:0006586)3.81673061
30activation of protein kinase A activity (GO:0034199)3.77812875
31regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.76122393
32eosinophil migration (GO:0072677)3.74716823
33proline transport (GO:0015824)3.70890922
34negative regulation of cell killing (GO:0031342)3.67672432
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67672432
36regulation of synapse structural plasticity (GO:0051823)3.61579023
37serotonin metabolic process (GO:0042428)3.56541214
38DNA deamination (GO:0045006)3.52192313
39regulation of synaptic vesicle transport (GO:1902803)3.50802083
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46929222
41preassembly of GPI anchor in ER membrane (GO:0016254)3.46306981
42primary amino compound metabolic process (GO:1901160)3.42602510
43regulation of sister chromatid cohesion (GO:0007063)3.42170830
44oxidative demethylation (GO:0070989)3.41832216
45regulation of ARF protein signal transduction (GO:0032012)3.38007822
46regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.36025026
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35663443
48positive regulation of interleukin-1 beta secretion (GO:0050718)3.32755992
49glycine transport (GO:0015816)3.32144371
50neurotransmitter secretion (GO:0007269)3.29751312
51protein import into peroxisome matrix (GO:0016558)3.22836968
52exploration behavior (GO:0035640)3.21447886
53tryptophan catabolic process (GO:0006569)3.16563919
54indole-containing compound catabolic process (GO:0042436)3.16563919
55indolalkylamine catabolic process (GO:0046218)3.16563919
56positive regulation by symbiont of host defense response (GO:0052509)3.14897523
57modulation by symbiont of host defense response (GO:0052031)3.14897523
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14897523
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14897523
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.14897523
61modulation by symbiont of host immune response (GO:0052553)3.14897523
62regulation of glutamate receptor signaling pathway (GO:1900449)3.12263689
63DNA demethylation (GO:0080111)3.11084440
64interferon-gamma production (GO:0032609)3.10685615
65positive regulation of interleukin-1 secretion (GO:0050716)3.10222544
66seminiferous tubule development (GO:0072520)3.08413740
67indole-containing compound metabolic process (GO:0042430)3.07984073
68vocalization behavior (GO:0071625)3.07168210
69fucosylation (GO:0036065)3.06516561
70histone H3-K9 methylation (GO:0051567)3.06433982
71positive regulation of vesicle fusion (GO:0031340)3.06381498
72regulation of interleukin-1 beta secretion (GO:0050706)3.04816768
73clathrin coat assembly (GO:0048268)3.03455888
74alanine transport (GO:0032328)3.02888910
75lactate metabolic process (GO:0006089)3.01482372
76regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.00322388
77detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.99982417
78regulation of neuronal synaptic plasticity (GO:0048168)2.99944802
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99080752
80behavioral response to nicotine (GO:0035095)2.96480750
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95999234
82cellular response to interleukin-15 (GO:0071350)2.94711306
83neural tube formation (GO:0001841)2.94573978
84regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93747635
85regulation of clathrin-mediated endocytosis (GO:2000369)2.92053164
86regulation of mononuclear cell migration (GO:0071675)2.91499785
87positive regulation of developmental pigmentation (GO:0048087)2.90819403
88layer formation in cerebral cortex (GO:0021819)2.89699028
89kynurenine metabolic process (GO:0070189)2.88577636
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.88565736
91detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.86967723
92fucose metabolic process (GO:0006004)2.86365099
93cell communication by electrical coupling (GO:0010644)2.85768303
94hepatocyte apoptotic process (GO:0097284)2.84667579
95positive regulation of calcium ion import (GO:0090280)2.81967095
96tryptophan metabolic process (GO:0006568)2.81355438
97tolerance induction (GO:0002507)2.80405073
98macrophage activation involved in immune response (GO:0002281)2.78834519
99regulation of interleukin-6 biosynthetic process (GO:0045408)2.77474034
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77142621
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.74411919
102response to host immune response (GO:0052572)2.74411919
103potassium ion import (GO:0010107)2.74094869
104negative regulation of T-helper cell differentiation (GO:0045623)2.73447880
105negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.73447880
106positive regulation of defense response to virus by host (GO:0002230)2.72975509
107vesicle transport along microtubule (GO:0047496)2.72534473
108regulation of interferon-beta biosynthetic process (GO:0045357)2.72446142
109regulation of ARF GTPase activity (GO:0032312)2.71354068
110positive regulation of lamellipodium assembly (GO:0010592)2.69888002
111nerve growth factor signaling pathway (GO:0038180)2.68715355
112detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.68451241
113positive regulation of granulocyte differentiation (GO:0030854)2.67064064
114detection of chemical stimulus involved in sensory perception (GO:0050907)2.66794009
115negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.63758882
116regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.62850150
117antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.61946473
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61946473
119response to host (GO:0075136)2.60355717
120response to host defenses (GO:0052200)2.60355717
121response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60355717
122neuromuscular process controlling balance (GO:0050885)2.58827669
123regulation of vesicle fusion (GO:0031338)2.57677626
124regulation of interleukin-1 secretion (GO:0050704)2.54218921
125positive regulation of interleukin-1 beta production (GO:0032731)2.54151697
126positive regulation of neurotransmitter secretion (GO:0001956)2.54087244
127positive regulation of lamellipodium organization (GO:1902745)2.53772458
128cAMP catabolic process (GO:0006198)2.53503720
129cytokine biosynthetic process (GO:0042089)2.53487715
130cellular sodium ion homeostasis (GO:0006883)2.53176316
131histone H3-K9 modification (GO:0061647)2.53044223
132positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.51590778
133positive regulation of T-helper 1 type immune response (GO:0002827)2.50807253
134regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.50390109
135regulation of B cell receptor signaling pathway (GO:0050855)2.50005924
136protein targeting to lysosome (GO:0006622)2.49838073
137establishment of protein localization to vacuole (GO:0072666)2.49838073
138protein targeting to vacuole (GO:0006623)2.49838073
139peptidyl-lysine trimethylation (GO:0018023)2.48958939
140cAMP biosynthetic process (GO:0006171)2.48727008
141establishment of nucleus localization (GO:0040023)2.47634197
142rRNA catabolic process (GO:0016075)2.47595692
143protein sumoylation (GO:0016925)2.47528347
144purinergic nucleotide receptor signaling pathway (GO:0035590)2.47511689
145positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47386760
146response to pheromone (GO:0019236)2.46548429
147neurotransmitter-gated ion channel clustering (GO:0072578)2.43928430
148regulation of synaptic plasticity (GO:0048167)2.43806172
149positive regulation of neurotransmitter transport (GO:0051590)2.43782786
150membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42703290
151detection of light stimulus involved in visual perception (GO:0050908)2.42683928
152detection of light stimulus involved in sensory perception (GO:0050962)2.42683928
153response to interleukin-15 (GO:0070672)2.42373318
154synaptic vesicle endocytosis (GO:0048488)2.41649748
155positive regulation of gamma-delta T cell activation (GO:0046645)2.41458844
156cytoskeletal anchoring at plasma membrane (GO:0007016)2.40847801
157protein localization to synapse (GO:0035418)2.40819366
158DNA dealkylation (GO:0035510)2.40124598
159negative regulation of mast cell activation (GO:0033004)2.39321447
160pantothenate metabolic process (GO:0015939)2.38601523
161long-term memory (GO:0007616)2.38547468
162regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.38284889
163intracellular pH reduction (GO:0051452)2.37799385
164neuronal action potential propagation (GO:0019227)2.37231926
165actin filament capping (GO:0051693)2.35660627
166replicative senescence (GO:0090399)2.35208700
167platelet dense granule organization (GO:0060155)2.33216499
168antigen processing and presentation of endogenous antigen (GO:0019883)2.33106330
169positive regulation of interferon-alpha production (GO:0032727)2.32487223
170protein localization to endosome (GO:0036010)2.32182948
171regulation of T-helper 1 type immune response (GO:0002825)2.31563911
172ionotropic glutamate receptor signaling pathway (GO:0035235)2.31246285
173cyclic nucleotide catabolic process (GO:0009214)2.30959263
174positive regulation of interleukin-1 production (GO:0032732)2.30325366
175double-strand break repair via homologous recombination (GO:0000724)2.29107487
176neurotransmitter transport (GO:0006836)2.29075287
177acrosome assembly (GO:0001675)2.27973293
178positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.27854861
179recombinational repair (GO:0000725)2.27837623
180axon cargo transport (GO:0008088)2.27718620
181potassium ion homeostasis (GO:0055075)2.27281805
182positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.27088167
183mitochondrial RNA metabolic process (GO:0000959)2.26392112
184cytokine metabolic process (GO:0042107)2.25167380
185phosphatidylserine acyl-chain remodeling (GO:0036150)2.25001322
186regulation of neurotransmitter secretion (GO:0046928)2.24726826
187positive regulation of Rap GTPase activity (GO:0032854)2.24110919
188positive regulation of membrane potential (GO:0045838)2.22904720
189membrane repolarization (GO:0086009)2.21986500
190signal complex assembly (GO:0007172)2.21763851
191interferon-gamma-mediated signaling pathway (GO:0060333)2.20937591
192gamma-aminobutyric acid transport (GO:0015812)2.20704682
193cerebellar Purkinje cell layer development (GO:0021680)2.20615472
194regulation of neurotransmitter levels (GO:0001505)2.20072619
195regulation of early endosome to late endosome transport (GO:2000641)2.20066503
196barbed-end actin filament capping (GO:0051016)2.20065172
197positive regulation of fibroblast migration (GO:0010763)2.19416202
198regulation of sodium ion transmembrane transporter activity (GO:2000649)2.16555174
199regulation of interferon-alpha production (GO:0032647)2.16431701

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.95033309
2NOTCH1_21737748_ChIP-Seq_TLL_Human3.56683645
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19135126
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.17918022
5ZNF274_21170338_ChIP-Seq_K562_Hela2.99742780
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.90039767
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87775955
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.79701487
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.74124607
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62183153
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39766466
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.38847151
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38704740
14GBX2_23144817_ChIP-Seq_PC3_Human2.36800073
15IGF1R_20145208_ChIP-Seq_DFB_Human2.22607921
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.14892212
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.13207744
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09732742
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08846100
20DROSHA_22980978_ChIP-Seq_HELA_Human2.05045888
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.01347072
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01318315
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.98610781
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98265500
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94489074
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94199878
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93828958
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.86691926
29TAF15_26573619_Chip-Seq_HEK293_Human1.86113841
30SPI1_23127762_ChIP-Seq_K562_Human1.82001650
31FUS_26573619_Chip-Seq_HEK293_Human1.78403780
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77060599
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76633065
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76042280
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75090251
36ER_23166858_ChIP-Seq_MCF-7_Human1.71876463
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.71100616
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70951933
39EZH2_22144423_ChIP-Seq_EOC_Human1.69800734
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68524121
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64130523
42VDR_23849224_ChIP-Seq_CD4+_Human1.63557135
43LXR_22292898_ChIP-Seq_THP-1_Human1.63160528
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62897591
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62616049
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62032691
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59960568
48* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58882627
49AR_21572438_ChIP-Seq_LNCaP_Human1.58520220
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57885019
51KDM2B_26808549_Chip-Seq_DND41_Human1.57775597
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57521829
53IRF1_19129219_ChIP-ChIP_H3396_Human1.56930130
54TCF7_22412390_ChIP-Seq_EML_Mouse1.56100711
55* GABP_17652178_ChIP-ChIP_JURKAT_Human1.55525278
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53464780
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53155104
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52314791
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50662166
60GATA3_26560356_Chip-Seq_TH2_Human1.49296734
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48761880
62* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48660179
63RUNX_20019798_ChIP-Seq_JUKART_Human1.47020062
64REST_21632747_ChIP-Seq_MESCs_Mouse1.45526964
65KDM2B_26808549_Chip-Seq_K562_Human1.44955320
66P300_19829295_ChIP-Seq_ESCs_Human1.44231253
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44113535
68ELK1_19687146_ChIP-ChIP_HELA_Human1.43563859
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42395128
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41340569
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41030974
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.40814176
73CBP_20019798_ChIP-Seq_JUKART_Human1.40112742
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40112742
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.39843665
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39784682
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39498471
78ZNF263_19887448_ChIP-Seq_K562_Human1.38605123
79* BCAT_22108803_ChIP-Seq_LS180_Human1.37449564
80EWS_26573619_Chip-Seq_HEK293_Human1.37439030
81RXR_22108803_ChIP-Seq_LS180_Human1.35612565
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34394705
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.34379878
84* REST_18959480_ChIP-ChIP_MESCs_Mouse1.33130573
85TP53_22573176_ChIP-Seq_HFKS_Human1.30991214
86STAT3_23295773_ChIP-Seq_U87_Human1.30856337
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30797672
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29840323
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.29674908
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28685435
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28406025
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27912805
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26999016
94* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26719632
95* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26719632
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24381197
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23979848
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23809344
99SCL_19346495_ChIP-Seq_HPC-7_Human1.23502438
100* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23066145
101VDR_21846776_ChIP-Seq_THP-1_Human1.22317603
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.21643615
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21587928
104FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21270934
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.21270934
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20230707
107MAF_26560356_Chip-Seq_TH1_Human1.19196840
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.18618279
109GATA1_22025678_ChIP-Seq_K562_Human1.18055764
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18045209
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17584779
112RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17584779
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17170901
114STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14752564
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14683938
116ELK3_25401928_ChIP-Seq_HUVEC_Human1.13252285
117VDR_24763502_ChIP-Seq_THP-1_Human1.12687506
118ESR1_20079471_ChIP-ChIP_T-47D_Human1.12656373
119GATA1_19941826_ChIP-Seq_K562_Human1.12482936
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11804103
121JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11798556
122JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10253084
123MYC_22102868_ChIP-Seq_BL_Human1.10186642
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09888770
125HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09872372
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.09806587
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09696519
128BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09301793
129SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09031129
130GATA2_19941826_ChIP-Seq_K562_Human1.08402525
131GATA3_26560356_Chip-Seq_TH1_Human1.08187556
132* TCF4_23295773_ChIP-Seq_U87_Human1.07910622
133SRF_21415370_ChIP-Seq_HL-1_Mouse1.06769910
134SOX2_19829295_ChIP-Seq_ESCs_Human1.06608396
135NANOG_19829295_ChIP-Seq_ESCs_Human1.06608396
136* TCF4_22108803_ChIP-Seq_LS180_Human1.06309588
137GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05756384
138SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05306868
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04894063
140FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04624112
141FLI1_21867929_ChIP-Seq_TH2_Mouse1.04538449
142ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04479102
143CDX2_22108803_ChIP-Seq_LS180_Human1.04027121
144AR_25329375_ChIP-Seq_VCAP_Human1.03950028
145P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03379599
146VDR_24787735_ChIP-Seq_THP-1_Human1.03334030
147FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03272013
148CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02303504
149RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01740665
150* TP53_16413492_ChIP-PET_HCT116_Human1.00527869
151SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00469336
152KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00008459
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99018123
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98788754
155GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98602081
156ERG_21242973_ChIP-ChIP_JURKAT_Human0.96811464
157STAT3_18555785_Chip-Seq_ESCs_Mouse0.96294836
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96084758
159EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95707618
160* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95521021
161EST1_17652178_ChIP-ChIP_JURKAT_Human0.95404839
162SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95219762
163EZH2_27294783_Chip-Seq_ESCs_Mouse0.94976607
164* SMAD4_21799915_ChIP-Seq_A2780_Human0.94849517
165* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94849366
166SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94643296
167MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94569545
168GATA3_27048872_Chip-Seq_THYMUS_Human0.94534340
169MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93459710
170P53_22387025_ChIP-Seq_ESCs_Mouse0.93339739
171LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92627658
172PIAS1_25552417_ChIP-Seq_VCAP_Human0.92445137
173TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91835443
174IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91642365
175* GATA2_21666600_ChIP-Seq_HMVEC_Human0.91459026
176* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91084404
177OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90955889
178E2F1_18555785_Chip-Seq_ESCs_Mouse0.90827117
179NANOG_18555785_Chip-Seq_ESCs_Mouse0.90490761
180TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89733281
181MYB_26560356_Chip-Seq_TH2_Human0.89090386
182UTX_26944678_Chip-Seq_JUKART_Human0.88112949
183RNF2_27304074_Chip-Seq_ESCs_Mouse0.87313907
184SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87041685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.85353305
2MP0006082_CNS_inflammation3.11110842
3MP0003635_abnormal_synaptic_transmissio2.84744998
4MP0003195_calcinosis2.60825217
5MP0004858_abnormal_nervous_system2.56015295
6MP0003763_abnormal_thymus_physiology2.50595509
7MP0000569_abnormal_digit_pigmentation2.37272600
8MP0004270_analgesia2.36045789
9MP0002876_abnormal_thyroid_physiology2.34001881
10MP0003300_gastrointestinal_ulcer2.30691540
11MP0003646_muscle_fatigue2.29338750
12MP0000566_synostosis2.23145077
13MP0001919_abnormal_reproductive_system2.20894303
14MP0003075_altered_response_to2.18758222
15MP0009046_muscle_twitch2.18423419
16MP0002063_abnormal_learning/memory/cond2.17108692
17MP0001968_abnormal_touch/_nociception2.16174947
18MP0010234_abnormal_vibrissa_follicle2.15205032
19MP0005058_abnormal_lysosome_morphology2.13243074
20MP0003172_abnormal_lysosome_physiology2.12580418
21MP0003183_abnormal_peptide_metabolism2.11926651
22MP0003303_peritoneal_inflammation2.06910348
23MP0002064_seizures2.06058198
24MP0009780_abnormal_chondrocyte_physiolo2.03200249
25MP0005084_abnormal_gallbladder_morpholo2.02012823
26MP0009745_abnormal_behavioral_response2.01711770
27MP0000383_abnormal_hair_follicle2.01329398
28MP0008877_abnormal_DNA_methylation1.99162553
29MP0002909_abnormal_adrenal_gland1.94422146
30MP0000604_amyloidosis1.91655764
31MP0003329_amyloid_beta_deposits1.85815946
32MP0002822_catalepsy1.83060163
33MP0004947_skin_inflammation1.79192008
34MP0001835_abnormal_antigen_presentation1.79124522
35MP0005389_reproductive_system_phenotype1.77053666
36MP0003880_abnormal_central_pattern1.74863710
37MP0001663_abnormal_digestive_system1.74283001
38MP0001986_abnormal_taste_sensitivity1.71309397
39MP0003787_abnormal_imprinting1.68291187
40MP0002138_abnormal_hepatobiliary_system1.58328760
41MP0000685_abnormal_immune_system1.57807647
42MP0003436_decreased_susceptibility_to1.57141619
43MP0002166_altered_tumor_susceptibility1.54848375
44MP0008569_lethality_at_weaning1.54563559
45MP0002735_abnormal_chemical_nociception1.54120470
46MP0002736_abnormal_nociception_after1.52133136
47MP0004510_myositis1.48926798
48MP0000372_irregular_coat_pigmentation1.48845448
49MP0001501_abnormal_sleep_pattern1.48251441
50MP0002006_tumorigenesis1.47500627
51MP0004130_abnormal_muscle_cell1.47204519
52MP0003633_abnormal_nervous_system1.46030256
53MP0002572_abnormal_emotion/affect_behav1.45913988
54MP0005253_abnormal_eye_physiology1.45552665
55MP0006072_abnormal_retinal_apoptosis1.45018391
56MP0004811_abnormal_neuron_physiology1.43726719
57MP0008875_abnormal_xenobiotic_pharmacok1.42552768
58MP0002751_abnormal_autonomic_nervous1.42422476
59MP0002734_abnormal_mechanical_nocicepti1.42045047
60MP0005075_abnormal_melanosome_morpholog1.40137291
61MP0002405_respiratory_system_inflammati1.39793092
62MP0001764_abnormal_homeostasis1.38697587
63MP0002733_abnormal_thermal_nociception1.38596690
64MP0008961_abnormal_basal_metabolism1.38220061
65MP0008057_abnormal_DNA_replication1.36965084
66MP0000427_abnormal_hair_cycle1.36742557
67MP0005310_abnormal_salivary_gland1.35099142
68MP0003705_abnormal_hypodermis_morpholog1.34896005
69MP0000689_abnormal_spleen_morphology1.33789721
70MP0001970_abnormal_pain_threshold1.32434899
71MP0005167_abnormal_blood-brain_barrier1.31594981
72MP0001664_abnormal_digestion1.29894597
73MP0005174_abnormal_tail_pigmentation1.29116602
74MP0005551_abnormal_eye_electrophysiolog1.28034911
75MP0003656_abnormal_erythrocyte_physiolo1.27995870
76MP0002419_abnormal_innate_immunity1.26764789
77MP0010352_gastrointestinal_tract_polyps1.26720363
78MP0005166_decreased_susceptibility_to1.25769924
79MP0005645_abnormal_hypothalamus_physiol1.24612657
80MP0003045_fibrosis1.24305517
81MP0000013_abnormal_adipose_tissue1.23249702
82MP0005000_abnormal_immune_tolerance1.22332520
83MP0002102_abnormal_ear_morphology1.22059438
84MP0000716_abnormal_immune_system1.20513534
85MP0010678_abnormal_skin_adnexa1.19932257
86MP0000015_abnormal_ear_pigmentation1.19613304
87MP0005464_abnormal_platelet_physiology1.19586821
88MP0002837_dystrophic_cardiac_calcinosis1.19289828
89MP0005387_immune_system_phenotype1.18642332
90MP0001790_abnormal_immune_system1.18642332
91MP0010155_abnormal_intestine_physiology1.14634381
92MP0003252_abnormal_bile_duct1.13049386
93MP0004043_abnormal_pH_regulation1.10135373
94MP0010386_abnormal_urinary_bladder1.08805126
95MP0004142_abnormal_muscle_tone1.08628999
96MP0003690_abnormal_glial_cell1.07329118
97MP0002693_abnormal_pancreas_physiology1.04230614
98MP0002452_abnormal_antigen_presenting1.04217599
99MP0001958_emphysema1.03861233
100MP0008058_abnormal_DNA_repair1.03121096
101MP0001819_abnormal_immune_cell1.01708151
102MP0002723_abnormal_immune_serum1.01595833
103MP0005381_digestive/alimentary_phenotyp1.01508301
104MP0005025_abnormal_response_to1.01464110
105MP0003879_abnormal_hair_cell1.01267877
106MP0002420_abnormal_adaptive_immunity1.00974489
107MP0009785_altered_susceptibility_to0.99825635
108MP0002928_abnormal_bile_duct0.99683461
109MP0003631_nervous_system_phenotype0.99247203
110MP0008995_early_reproductive_senescence0.98613658
111MP0004924_abnormal_behavior0.98444090
112MP0005386_behavior/neurological_phenoty0.98444090
113MP0001533_abnormal_skeleton_physiology0.98051275
114MP0001800_abnormal_humoral_immune0.98033880
115MP0008874_decreased_physiological_sensi0.97484539
116MP0001545_abnormal_hematopoietic_system0.97480902
117MP0005397_hematopoietic_system_phenotyp0.97480902
118MP0002722_abnormal_immune_system0.96916651
119MP0002272_abnormal_nervous_system0.96270392
120MP0005671_abnormal_response_to0.96031966
121MP0001873_stomach_inflammation0.95592968
122MP0002067_abnormal_sensory_capabilities0.94840354
123MP0005646_abnormal_pituitary_gland0.93996515
124MP0003866_abnormal_defecation0.93238290
125MP0002277_abnormal_respiratory_mucosa0.92341036
126MP0001486_abnormal_startle_reflex0.91015510
127MP0002009_preneoplasia0.90399433
128MP0005584_abnormal_enzyme/coenzyme_acti0.89780486
129MP0009764_decreased_sensitivity_to0.89060464
130MP0002933_joint_inflammation0.88863761
131MP0002429_abnormal_blood_cell0.88431483
132MP0002090_abnormal_vision0.87729487
133MP0002148_abnormal_hypersensitivity_rea0.87339902
134MP0003191_abnormal_cellular_cholesterol0.87309483
135MP0000470_abnormal_stomach_morphology0.85936916
136MP0004381_abnormal_hair_follicle0.85473652
137MP0008469_abnormal_protein_level0.85221494
138MP0005647_abnormal_sex_gland0.85166633
139MP0001440_abnormal_grooming_behavior0.84817771
140MP0000703_abnormal_thymus_morphology0.84661323
141MP0002254_reproductive_system_inflammat0.84231432
142MP0005423_abnormal_somatic_nervous0.84202836
143MP0001853_heart_inflammation0.82724349
144MP0005076_abnormal_cell_differentiation0.81950059
145MP0003566_abnormal_cell_adhesion0.81913789
146MP0005535_abnormal_body_temperature0.81619516
147MP0002998_abnormal_bone_remodeling0.80953909
148MP0001765_abnormal_ion_homeostasis0.80194857
149MP0008872_abnormal_physiological_respon0.80022758
150MP0002095_abnormal_skin_pigmentation0.79099136
151MP0002638_abnormal_pupillary_reflex0.78781288
152MP0001845_abnormal_inflammatory_respons0.78550868
153MP0003091_abnormal_cell_migration0.76740826
154MP0000371_diluted_coat_color0.75732813
155MP0003724_increased_susceptibility_to0.75675621
156MP0003786_premature_aging0.75563473
157MP0003943_abnormal_hepatobiliary_system0.74573438
158MP0005379_endocrine/exocrine_gland_phen0.74461275
159MP0002136_abnormal_kidney_physiology0.72933841
160MP0002557_abnormal_social/conspecific_i0.72604648
161MP0003011_delayed_dark_adaptation0.72542515
162MP0000465_gastrointestinal_hemorrhage0.71882538
163MP0002398_abnormal_bone_marrow0.71878910
164MP0002019_abnormal_tumor_incidence0.71071871
165MP0001348_abnormal_lacrimal_gland0.68863975
166MP0002066_abnormal_motor_capabilities/c0.68637060
167MP0003448_altered_tumor_morphology0.68585066
168MP0009333_abnormal_splenocyte_physiolog0.66096609
169MP0002163_abnormal_gland_morphology0.65388914

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.22250953
2Papilledema (HP:0001085)4.16177792
3Duplicated collecting system (HP:0000081)4.12530281
4Abnormality of the renal collecting system (HP:0004742)3.90296513
5Focal motor seizures (HP:0011153)3.80727819
6Stomatitis (HP:0010280)3.60003488
7Large for gestational age (HP:0001520)3.57915366
8Congenital stationary night blindness (HP:0007642)3.51492107
9Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.51024097
10Visual hallucinations (HP:0002367)3.39035192
11Chronic mucocutaneous candidiasis (HP:0002728)3.34068507
12Recurrent cutaneous fungal infections (HP:0011370)3.34068507
13Pancreatic cysts (HP:0001737)3.25289711
14Action tremor (HP:0002345)3.22817472
15Increased cerebral lipofuscin (HP:0011813)3.21139396
16Molar tooth sign on MRI (HP:0002419)3.15648341
17Abnormality of midbrain morphology (HP:0002418)3.15648341
18IgG deficiency (HP:0004315)3.14260611
19Supranuclear gaze palsy (HP:0000605)3.09646619
20Focal seizures (HP:0007359)2.96816604
21Mutism (HP:0002300)2.96565072
22Attenuation of retinal blood vessels (HP:0007843)2.95649220
23Eczematoid dermatitis (HP:0000976)2.94922351
24Abnormality of the renal cortex (HP:0011035)2.93813499
25Type II lissencephaly (HP:0007260)2.91428351
26Impaired vibration sensation in the lower limbs (HP:0002166)2.84846600
27Epileptic encephalopathy (HP:0200134)2.79745471
28Autoimmune thrombocytopenia (HP:0001973)2.73932705
29Abnormality of T cell number (HP:0011839)2.72061817
30Widely spaced teeth (HP:0000687)2.71989983
31Disinhibition (HP:0000734)2.71576746
32Recurrent fungal infections (HP:0002841)2.71271542
33Adactyly (HP:0009776)2.68751906
34Recurrent abscess formation (HP:0002722)2.68679632
35Acute lymphatic leukemia (HP:0006721)2.67862546
36Diminished motivation (HP:0000745)2.66427337
37Depression (HP:0000716)2.65102948
38Dysostosis multiplex (HP:0000943)2.64748221
39Apathy (HP:0000741)2.64463928
40T lymphocytopenia (HP:0005403)2.58156719
41Recurrent gram-negative bacterial infections (HP:0005420)2.55054887
42Urinary urgency (HP:0000012)2.54960574
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.52922121
44Renal cortical cysts (HP:0000803)2.52486466
45Ankle clonus (HP:0011448)2.47407970
46Anhidrosis (HP:0000970)2.46429556
47Urinary bladder sphincter dysfunction (HP:0002839)2.45826024
48Recurrent bacterial skin infections (HP:0005406)2.45784479
49Absence seizures (HP:0002121)2.45564900
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.44847245
51Thyroiditis (HP:0100646)2.44157445
52Poor eye contact (HP:0000817)2.43728117
53Long toe (HP:0010511)2.43572323
54Truncal ataxia (HP:0002078)2.43559490
55Hypoplastic iliac wings (HP:0002866)2.39751409
56Clubbing of toes (HP:0100760)2.39730232
57Inappropriate behavior (HP:0000719)2.39556668
58Abnormality of the pons (HP:0007361)2.39179679
59Abnormality of T cells (HP:0002843)2.35537668
60Abnormality of macrophages (HP:0004311)2.35289037
61Hemiplegia (HP:0002301)2.33647501
62Loss of speech (HP:0002371)2.33396529
63Impaired social interactions (HP:0000735)2.32706317
64Abnormal social behavior (HP:0012433)2.32706317
65Neuroendocrine neoplasm (HP:0100634)2.32149352
66Pheochromocytoma (HP:0002666)2.31439062
67Generalized tonic-clonic seizures (HP:0002069)2.29754143
68True hermaphroditism (HP:0010459)2.28204396
69Pancreatic fibrosis (HP:0100732)2.27652666
70Inability to walk (HP:0002540)2.27168864
71Polydipsia (HP:0001959)2.26832189
72Abnormal drinking behavior (HP:0030082)2.26832189
73Progressive cerebellar ataxia (HP:0002073)2.24976835
74Stomach cancer (HP:0012126)2.24652181
75Termporal pattern (HP:0011008)2.24078589
76Insidious onset (HP:0003587)2.24078589
77Abolished electroretinogram (ERG) (HP:0000550)2.23975711
78Postural instability (HP:0002172)2.23807683
79Chronic otitis media (HP:0000389)2.23546687
80Nephronophthisis (HP:0000090)2.22925604
81Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22211121
82Dysmetric saccades (HP:0000641)2.21329777
83Volvulus (HP:0002580)2.20935350
84Polygenic inheritance (HP:0010982)2.20021285
85Ankyloglossia (HP:0010296)2.19928299
86Tetraparesis (HP:0002273)2.19818381
87Neuronal loss in central nervous system (HP:0002529)2.19164152
88Neoplasm of the peripheral nervous system (HP:0100007)2.18096929
89Elevated erythrocyte sedimentation rate (HP:0003565)2.16294787
90Global brain atrophy (HP:0002283)2.16158619
91Abnormality of T cell physiology (HP:0011840)2.16102948
92Hypoplasia of the pons (HP:0012110)2.15889754
93Long foot (HP:0001833)2.15524904
94Abnormality of B cell number (HP:0010975)2.15258846
95Polyuria (HP:0000103)2.13397222
96Abnormal eating behavior (HP:0100738)2.13325286
97Brushfield spots (HP:0001088)2.12689571
98Dry hair (HP:0011359)2.11433089
99Achilles tendon contracture (HP:0001771)2.11003767
100Optic neuritis (HP:0100653)2.10669175
101Retrobulbar optic neuritis (HP:0100654)2.10669175
102Hyperventilation (HP:0002883)2.10469942
103Anxiety (HP:0000739)2.08663734
104Urinary glycosaminoglycan excretion (HP:0003541)2.07815748
105Mucopolysacchariduria (HP:0008155)2.07815748
106Megalencephaly (HP:0001355)2.07768425
107Abnormality of the renal medulla (HP:0100957)2.07159735
108Genetic anticipation (HP:0003743)2.05068939
109Hypercortisolism (HP:0001578)2.04188758
110Abnormality of oral frenula (HP:0000190)2.03540479
111Atonic seizures (HP:0010819)2.03093922
112Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01841194
113Clumsiness (HP:0002312)2.00950616
114Insomnia (HP:0100785)2.00517878
115Pustule (HP:0200039)2.00032323
116Diplopia (HP:0000651)1.99911923
117Abnormality of binocular vision (HP:0011514)1.99911923
118Panhypogammaglobulinemia (HP:0003139)1.98952260
119Autoimmune hemolytic anemia (HP:0001890)1.98576898
120Rapidly progressive (HP:0003678)1.96709618
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.96594500
122Absent/shortened dynein arms (HP:0200106)1.96594500
123Medial flaring of the eyebrow (HP:0010747)1.96385003
124Stereotypic behavior (HP:0000733)1.95711407
125Mediastinal lymphadenopathy (HP:0100721)1.95517562
126Ureteral obstruction (HP:0006000)1.94819959
127Abnormality of polysaccharide metabolism (HP:0011012)1.94728265
128Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94728265
129Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94728265
130Ureteral stenosis (HP:0000071)1.94091763
131Tetany (HP:0001281)1.93721823
132Impaired smooth pursuit (HP:0007772)1.93314955
133Constricted visual fields (HP:0001133)1.93038528
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93013144
135Abnormality of alanine metabolism (HP:0010916)1.93013144
136Hyperalaninemia (HP:0003348)1.93013144
137Abnormality of the Achilles tendon (HP:0005109)1.92871597
138Increased number of teeth (HP:0011069)1.92294356
139Frequent falls (HP:0002359)1.91985456
140Dialeptic seizures (HP:0011146)1.91653558
141Cerebral inclusion bodies (HP:0100314)1.91406155
142Rigidity (HP:0002063)1.91399202
143Broad-based gait (HP:0002136)1.91213942
144Pointed chin (HP:0000307)1.91017011
145Status epilepticus (HP:0002133)1.90631377
146Abnormality of macular pigmentation (HP:0008002)1.90540929
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90265917
148Congenital, generalized hypertrichosis (HP:0004540)1.90262291
149Gaze-evoked nystagmus (HP:0000640)1.90124350
150Upper limb amyotrophy (HP:0009129)1.89972581
151Distal upper limb amyotrophy (HP:0007149)1.89972581
152Abnormal rod and cone electroretinograms (HP:0008323)1.89165908
153Abnormality of eosinophils (HP:0001879)1.88974904
154Cerebellar dysplasia (HP:0007033)1.87448161
155Torticollis (HP:0000473)1.86631281
156Abnormality of the prostate (HP:0008775)1.86284710
157Hemoptysis (HP:0002105)1.86002794
158Interstitial pulmonary disease (HP:0006530)1.85596487
159Ureteral duplication (HP:0000073)1.85294274
160Eosinophilia (HP:0001880)1.84969067
161Hand muscle atrophy (HP:0009130)1.84739908
162Prostate neoplasm (HP:0100787)1.84656064
163Ventricular fibrillation (HP:0001663)1.83472746
164Striae distensae (HP:0001065)1.83062457
165Decreased circulating renin level (HP:0003351)1.83047918
166Albinism (HP:0001022)1.82761322
167Tubular atrophy (HP:0000092)1.82721060
168Dementia (HP:0000726)1.82367283
169Resting tremor (HP:0002322)1.81517617
170Abnormality of ocular smooth pursuit (HP:0000617)1.81219882
171B lymphocytopenia (HP:0010976)1.81159881
172Recurrent skin infections (HP:0001581)1.80854165
173Keratoconjunctivitis (HP:0001096)1.80841348
174Axonal loss (HP:0003447)1.80128376
175Intention tremor (HP:0002080)1.80041842
176Hematochezia (HP:0002573)1.79795977
177Keratoconus (HP:0000563)1.79027857
178Increased corneal curvature (HP:0100692)1.79027857
179Recurrent bronchitis (HP:0002837)1.78907335
180Chorioretinal atrophy (HP:0000533)1.78742767
181Neurofibrillary tangles (HP:0002185)1.78631059
182Increased CSF protein (HP:0002922)1.78348890
183Polyneuropathy (HP:0001271)1.78143704
184Chronic hepatic failure (HP:0100626)1.76974487
185Exercise-induced myalgia (HP:0003738)1.76963439
186Ketosis (HP:0001946)1.76319056
187Protruding tongue (HP:0010808)1.76250575
188Agitation (HP:0000713)1.75998566
189Hypoplastic nipples (HP:0002557)1.75695939
190Myositis (HP:0100614)1.75577447
191Fair hair (HP:0002286)1.75240250
192Pulmonary infiltrates (HP:0002113)1.75160525
193Lower limb amyotrophy (HP:0007210)1.75158510
194Dysmetria (HP:0001310)1.74905452
195Leukocytosis (HP:0001974)1.74518441
196Bradykinesia (HP:0002067)1.74201556
197Encephalitis (HP:0002383)1.74038951
198Progressive inability to walk (HP:0002505)1.73940322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK27.03656214
2MKNK13.95243051
3MAP3K93.44258946
4ACVR1B3.43427309
5TRIB32.86801191
6KSR22.71676641
7RIPK42.55974753
8TAOK22.53060249
9MAP2K32.45400952
10TXK2.42048845
11NTRK32.41061234
12MAP3K42.35255492
13DAPK22.34519046
14MST42.34166711
15CAMKK12.29576446
16EPHA42.26514564
17RIPK12.25294734
18MINK12.15830912
19ADRBK22.15341820
20MAP3K32.14509594
21INSRR2.13190553
22MAP3K132.01441974
23NTRK11.90044592
24NUAK11.86608584
25DAPK11.85125080
26PKN21.79629785
27TLK11.77779007
28TAOK11.74281346
29MAPKAPK31.73650534
30ZAK1.73550744
31PAK61.72869628
32TEC1.72068227
33JAK11.67411009
34STK391.66100032
35SCYL21.65400481
36CAMKK21.63885983
37WNK41.61898611
38MAP4K21.61666126
39TYK21.51467850
40MAP2K41.49209985
41RET1.47868231
42SIK21.46919792
43ERN11.43013983
44MAP2K71.39656753
45LRRK21.38955680
46MAP3K121.36560144
47PRKD31.35976038
48NEK11.33034977
49TNK21.32530601
50TBK11.32392483
51GRK11.29288847
52OXSR11.28947279
53CDK51.26571151
54EEF2K1.26160378
55LMTK21.24544494
56FES1.22400852
57RAF11.17916196
58PRKCH1.17804432
59KIT1.17398215
60MAP3K11.16344185
61DMPK1.13651753
62PDK11.12959286
63BMPR1B1.12749853
64MAP3K21.10062211
65JAK21.08888024
66PINK11.08312261
67PRKCQ1.07850686
68MAP4K11.04184778
69IKBKB1.03180247
70DYRK1A0.98540562
71MARK10.98369868
72NLK0.97131519
73ARAF0.95662192
74PTK60.95580091
75BMPR20.94794897
76EIF2AK30.94143998
77WNK30.93168332
78MARK30.92997863
79CDK190.90600068
80BLK0.89476227
81KSR10.87904908
82SGK30.87517413
83NTRK20.87351265
84MAP3K140.86566239
85ABL20.86252092
86PDPK10.86251803
87MAPK130.85976718
88ITK0.85781114
89ALK0.85646557
90SYK0.80226877
91MAP3K70.79029618
92PRKCG0.78701804
93PIK3CG0.76311997
94ERBB30.74737208
95MAPK120.72661374
96SRPK10.72524164
97ADRBK10.71515097
98FGFR30.71030074
99FER0.69476271
100BMX0.68727706
101CAMK1D0.67722299
102DAPK30.66368760
103PIK3CA0.66256309
104TRPM70.66060553
105IRAK10.65765900
106HCK0.64856698
107BTK0.63817009
108GRK50.63453271
109IKBKE0.62547495
110STK110.62516807
111CHEK20.61998231
112MAP2K10.61908947
113PHKG10.61763114
114PHKG20.61763114
115JAK30.61044644
116ZAP700.58956351
117PDGFRA0.58570290
118TESK10.57825863
119LCK0.55983401
120CASK0.55824827
121FYN0.55576955
122STK380.54795650
123PAK30.53336258
124GRK60.53259451
125CDK140.52507483
126MAP2K60.51965195
127TAOK30.51753976
128AKT30.51041436
129LYN0.50292653
130CDK150.50023984
131MAP3K50.49881848
132TTN0.49850771
133ABL10.49686732
134PTK2B0.49394334
135SGK10.49073677
136CDK180.47784180
137FLT30.47667076
138CAMK1G0.47223705
139RPS6KA20.46482692
140GRK70.46104241
141SIK10.45850936
142RPS6KA50.44759316
143MAP3K110.44330002
144CAMK10.44287365
145CSF1R0.43774403
146PLK20.43543360
147PRKCE0.42991581
148EPHA30.42893683
149CHUK0.41584275
150FGFR40.40941790
151CDK11A0.40733867
152CCNB10.40509790
153SRC0.40498627
154PIM10.39937127
155STK30.39851483
156MAP2K20.38732712
157IGF1R0.38309639
158OBSCN0.37775372
159FRK0.37651605
160FGR0.37008875
161BRSK20.35930034
162EGFR0.35253065
163BRD40.30984655
164PRKCI0.30616505
165HIPK20.25626141
166CSK0.24798623
167TNIK0.24259148
168IRAK40.23293049
169MUSK0.21380883
170STK160.19862845
171VRK10.19538312
172CSNK1A10.19475102
173SGK20.19400005
174TRIM280.15190931

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.77027590
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.67524621
3Primary immunodeficiency_Homo sapiens_hsa053402.66284972
4Synaptic vesicle cycle_Homo sapiens_hsa047212.53732268
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45737252
6RNA polymerase_Homo sapiens_hsa030202.41086891
7Allograft rejection_Homo sapiens_hsa053302.34286980
8Graft-versus-host disease_Homo sapiens_hsa053322.32020967
9Asthma_Homo sapiens_hsa053102.28976382
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24341734
11Autoimmune thyroid disease_Homo sapiens_hsa053202.19643001
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13897711
13* SNARE interactions in vesicular transport_Homo sapiens_hsa041302.12128635
14Olfactory transduction_Homo sapiens_hsa047401.99711703
15Long-term potentiation_Homo sapiens_hsa047201.97838095
16Tryptophan metabolism_Homo sapiens_hsa003801.93478758
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.79226363
18Linoleic acid metabolism_Homo sapiens_hsa005911.78661158
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78610339
20Circadian entrainment_Homo sapiens_hsa047131.77663993
21Homologous recombination_Homo sapiens_hsa034401.67824363
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67236347
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66692802
24Phototransduction_Homo sapiens_hsa047441.66336003
25Selenocompound metabolism_Homo sapiens_hsa004501.66219566
26Gastric acid secretion_Homo sapiens_hsa049711.66014366
27Salivary secretion_Homo sapiens_hsa049701.56823647
28GABAergic synapse_Homo sapiens_hsa047271.52768068
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52341514
30Taste transduction_Homo sapiens_hsa047421.48556056
31Nitrogen metabolism_Homo sapiens_hsa009101.48287365
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45342405
33Butanoate metabolism_Homo sapiens_hsa006501.45172666
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44690298
35Cholinergic synapse_Homo sapiens_hsa047251.43348298
36Morphine addiction_Homo sapiens_hsa050321.41057941
37Glutamatergic synapse_Homo sapiens_hsa047241.40234553
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39667570
39Rheumatoid arthritis_Homo sapiens_hsa053231.38554486
40Hematopoietic cell lineage_Homo sapiens_hsa046401.38458389
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.37456660
42Caffeine metabolism_Homo sapiens_hsa002321.36094459
43Insulin secretion_Homo sapiens_hsa049111.36085023
44Dopaminergic synapse_Homo sapiens_hsa047281.36007854
45Amphetamine addiction_Homo sapiens_hsa050311.34570200
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34535730
47GnRH signaling pathway_Homo sapiens_hsa049121.33789483
48Glioma_Homo sapiens_hsa052141.33726399
49Type II diabetes mellitus_Homo sapiens_hsa049301.33518758
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31785493
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30170569
52Antigen processing and presentation_Homo sapiens_hsa046121.29277614
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28630231
54Renin secretion_Homo sapiens_hsa049241.27782940
55Ether lipid metabolism_Homo sapiens_hsa005651.27456901
56Oxytocin signaling pathway_Homo sapiens_hsa049211.27329773
57Nicotine addiction_Homo sapiens_hsa050331.27260499
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.26139485
59Non-homologous end-joining_Homo sapiens_hsa034501.25743524
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.24010854
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23010713
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22865179
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22490520
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.20089722
65Osteoclast differentiation_Homo sapiens_hsa043801.18627249
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18406638
67RNA degradation_Homo sapiens_hsa030181.18341464
68Basal transcription factors_Homo sapiens_hsa030221.18175599
69Tuberculosis_Homo sapiens_hsa051521.14390305
70VEGF signaling pathway_Homo sapiens_hsa043701.12194175
71Fanconi anemia pathway_Homo sapiens_hsa034601.11427610
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10665571
73mTOR signaling pathway_Homo sapiens_hsa041501.06873133
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06043116
75Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05642848
76Estrogen signaling pathway_Homo sapiens_hsa049151.04962559
77Staphylococcus aureus infection_Homo sapiens_hsa051501.04729339
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04283565
79One carbon pool by folate_Homo sapiens_hsa006701.04083127
80Regulation of autophagy_Homo sapiens_hsa041401.02742381
81Nucleotide excision repair_Homo sapiens_hsa034201.02166988
82Proteasome_Homo sapiens_hsa030501.01200150
83Leishmaniasis_Homo sapiens_hsa051400.99804327
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99508104
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99453400
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99228864
87Systemic lupus erythematosus_Homo sapiens_hsa053220.97786365
88cAMP signaling pathway_Homo sapiens_hsa040240.97163197
89Glycerolipid metabolism_Homo sapiens_hsa005610.96775248
90Gap junction_Homo sapiens_hsa045400.96153772
91B cell receptor signaling pathway_Homo sapiens_hsa046620.96076231
92Chemokine signaling pathway_Homo sapiens_hsa040620.96055796
93Propanoate metabolism_Homo sapiens_hsa006400.95905357
94Calcium signaling pathway_Homo sapiens_hsa040200.95556761
95Lysosome_Homo sapiens_hsa041420.94126404
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93551939
97Salmonella infection_Homo sapiens_hsa051320.93167680
98Measles_Homo sapiens_hsa051620.90714572
99Pancreatic secretion_Homo sapiens_hsa049720.90563995
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90074916
101Endocytosis_Homo sapiens_hsa041440.89024573
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88591626
103Shigellosis_Homo sapiens_hsa051310.88056360
104Long-term depression_Homo sapiens_hsa047300.87638613
105Platelet activation_Homo sapiens_hsa046110.86677013
106Non-small cell lung cancer_Homo sapiens_hsa052230.86322853
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84088021
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.83756310
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83611572
110Cocaine addiction_Homo sapiens_hsa050300.81999061
111Viral myocarditis_Homo sapiens_hsa054160.80976596
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.80327056
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80145591
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79380730
115Dorso-ventral axis formation_Homo sapiens_hsa043200.78543552
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.78126591
117Toxoplasmosis_Homo sapiens_hsa051450.77582113
118TNF signaling pathway_Homo sapiens_hsa046680.77505507
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76872043
120Arachidonic acid metabolism_Homo sapiens_hsa005900.76769481
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.75220950
122Chemical carcinogenesis_Homo sapiens_hsa052040.74789608
123ErbB signaling pathway_Homo sapiens_hsa040120.74779569
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74015568
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.73808108
126Peroxisome_Homo sapiens_hsa041460.72245420
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71393588
128Sulfur metabolism_Homo sapiens_hsa009200.71147993
129Insulin signaling pathway_Homo sapiens_hsa049100.70940531
130Pancreatic cancer_Homo sapiens_hsa052120.69479981
131Protein export_Homo sapiens_hsa030600.69159508
132Pertussis_Homo sapiens_hsa051330.69038622
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68845201
134Prolactin signaling pathway_Homo sapiens_hsa049170.68831259
135ABC transporters_Homo sapiens_hsa020100.67457837
136Collecting duct acid secretion_Homo sapiens_hsa049660.66011135
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.65797859
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64903489
139Chronic myeloid leukemia_Homo sapiens_hsa052200.64639748
140Purine metabolism_Homo sapiens_hsa002300.64244835
141Insulin resistance_Homo sapiens_hsa049310.64111853
142Serotonergic synapse_Homo sapiens_hsa047260.64029502
143Thyroid hormone synthesis_Homo sapiens_hsa049180.61003389
144Type I diabetes mellitus_Homo sapiens_hsa049400.60422841
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60301017
146African trypanosomiasis_Homo sapiens_hsa051430.60046137
147Dilated cardiomyopathy_Homo sapiens_hsa054140.58748317
148T cell receptor signaling pathway_Homo sapiens_hsa046600.58661086
149Apoptosis_Homo sapiens_hsa042100.57713459
150Hepatitis B_Homo sapiens_hsa051610.57647104
151Choline metabolism in cancer_Homo sapiens_hsa052310.57364396
152Influenza A_Homo sapiens_hsa051640.57065469
153Phagosome_Homo sapiens_hsa041450.56925755
154MAPK signaling pathway_Homo sapiens_hsa040100.56896087
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56559151
156Bile secretion_Homo sapiens_hsa049760.56318362
157Amoebiasis_Homo sapiens_hsa051460.56225623
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.55748153
159Ovarian steroidogenesis_Homo sapiens_hsa049130.55659292
160Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55452481
161Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55300046
162Fatty acid elongation_Homo sapiens_hsa000620.55024162
163NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54590515
164Herpes simplex infection_Homo sapiens_hsa051680.54396881
165Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54313205
166Legionellosis_Homo sapiens_hsa051340.54031925
167Lysine degradation_Homo sapiens_hsa003100.52332393
168Malaria_Homo sapiens_hsa051440.51798265
169Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51121078
170Pyrimidine metabolism_Homo sapiens_hsa002400.49166477
171Epstein-Barr virus infection_Homo sapiens_hsa051690.48383070
172Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48352130
173beta-Alanine metabolism_Homo sapiens_hsa004100.45353388
174Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43517412
175Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40940517
176Circadian rhythm_Homo sapiens_hsa047100.39401716
177Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38944254

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