VTI1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1barbed-end actin filament capping (GO:0051016)5.01248630
2NADH metabolic process (GO:0006734)4.65602439
3synaptic vesicle exocytosis (GO:0016079)4.56024225
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.54583246
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.49716382
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30146333
7synaptic vesicle maturation (GO:0016188)4.27636587
8protein maturation by protein folding (GO:0022417)4.21219967
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.16939101
10ATP synthesis coupled proton transport (GO:0015986)4.16939101
11fibril organization (GO:0097435)4.12628684
12COPI coating of Golgi vesicle (GO:0048205)4.10939017
13Golgi transport vesicle coating (GO:0048200)4.10939017
14protein localization to endosome (GO:0036010)4.04612463
15vocalization behavior (GO:0071625)3.98773290
16neuronal action potential propagation (GO:0019227)3.98741781
17positive regulation of receptor recycling (GO:0001921)3.92457871
18extracellular fibril organization (GO:0043206)3.92340873
19glutamate secretion (GO:0014047)3.90451191
20respiratory electron transport chain (GO:0022904)3.82084493
21electron transport chain (GO:0022900)3.74012805
22regulation of synaptic vesicle exocytosis (GO:2000300)3.71438823
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68961280
24stress fiber assembly (GO:0043149)3.66046666
25protein retention in ER lumen (GO:0006621)3.64197943
26negative regulation of protein localization to plasma membrane (GO:1903077)3.64017251
27protein localization to synapse (GO:0035418)3.63891854
28regulation of integrin-mediated signaling pathway (GO:2001044)3.60046952
29neuron cell-cell adhesion (GO:0007158)3.52768113
30glycosphingolipid catabolic process (GO:0046479)3.50492173
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.49464262
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.46830650
33locomotory exploration behavior (GO:0035641)3.40614765
34neurotransmitter secretion (GO:0007269)3.39744770
35positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.39711214
36energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.38903123
37ATP hydrolysis coupled proton transport (GO:0015991)3.38903123
38regulation of synapse structural plasticity (GO:0051823)3.35519070
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32199563
40glycolipid catabolic process (GO:0019377)3.30257601
41retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30235657
42regulation of synaptic vesicle transport (GO:1902803)3.30111160
43protoporphyrinogen IX metabolic process (GO:0046501)3.27934171
44negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.27362936
45regulation of glutamate receptor signaling pathway (GO:1900449)3.26226563
46regulation of glutamate secretion (GO:0014048)3.24292962
47positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.24258055
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22432403
49alpha-linolenic acid metabolic process (GO:0036109)3.20272459
50regulation of early endosome to late endosome transport (GO:2000641)3.18247421
51proline transport (GO:0015824)3.16694806
52adenosine receptor signaling pathway (GO:0001973)3.14757612
53cellular response to thyroid hormone stimulus (GO:0097067)3.13902840
54protein hydroxylation (GO:0018126)3.13279796
55peptidyl-proline hydroxylation (GO:0019511)3.11343165
56synaptic vesicle docking involved in exocytosis (GO:0016081)3.08989350
57nucleobase-containing small molecule interconversion (GO:0015949)3.07835311
58regulation of neuronal synaptic plasticity (GO:0048168)3.07518631
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07257393
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.07226285
61type B pancreatic cell proliferation (GO:0044342)3.07131015
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05774204
63cellular potassium ion homeostasis (GO:0030007)3.04562096
64regulation of vesicle fusion (GO:0031338)3.04102404
65nucleoside diphosphate biosynthetic process (GO:0009133)3.02422748
66negative regulation of cation channel activity (GO:2001258)3.02290829
67ionotropic glutamate receptor signaling pathway (GO:0035235)3.01421635
68neuron-neuron synaptic transmission (GO:0007270)3.00681362
69beta-amyloid metabolic process (GO:0050435)2.96518940
70regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.96474661
71calcium-mediated signaling using intracellular calcium source (GO:0035584)2.94901021
72negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.94861765
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93994273
74synaptic transmission, glutamatergic (GO:0035249)2.93042637
75pentose-phosphate shunt (GO:0006098)2.87998738
76pinocytosis (GO:0006907)2.87627309
77synaptic transmission, dopaminergic (GO:0001963)2.86857123
78negative regulation of adherens junction organization (GO:1903392)2.86222041
79negative regulation of focal adhesion assembly (GO:0051895)2.86222041
80negative regulation of cell junction assembly (GO:1901889)2.86222041
81layer formation in cerebral cortex (GO:0021819)2.85654519
82triglyceride catabolic process (GO:0019433)2.85029081
83low-density lipoprotein particle clearance (GO:0034383)2.82690765
84neurotransmitter transport (GO:0006836)2.81142367
85transferrin transport (GO:0033572)2.80429264
86hydrogen ion transmembrane transport (GO:1902600)2.80215430
87exploration behavior (GO:0035640)2.79633712
88regulation of protein kinase A signaling (GO:0010738)2.78822630
89activation of protein kinase A activity (GO:0034199)2.78059198
90regulation of receptor recycling (GO:0001919)2.76892811
91negative regulation of amino acid transport (GO:0051956)2.75752090
92mating behavior (GO:0007617)2.75556913
93regulation of voltage-gated calcium channel activity (GO:1901385)2.75442631
94gamma-aminobutyric acid transport (GO:0015812)2.73439428
95glutamate receptor signaling pathway (GO:0007215)2.71996676
96response to thyroid hormone (GO:0097066)2.70668190
97negative regulation of smooth muscle cell migration (GO:0014912)2.70423272
98gamma-aminobutyric acid signaling pathway (GO:0007214)2.70374655
99neurotransmitter-gated ion channel clustering (GO:0072578)2.69608349
100behavioral response to cocaine (GO:0048148)2.69157455
101negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.68072816
102skin morphogenesis (GO:0043589)2.67663375
103tricarboxylic acid cycle (GO:0006099)2.67378268
104regulation of neurotransmitter levels (GO:0001505)2.66763645
105chaperone-mediated protein transport (GO:0072321)2.66328511
1062-deoxyribonucleotide biosynthetic process (GO:0009265)2.66075954
107deoxyribose phosphate biosynthetic process (GO:0046385)2.66075954
108neuromuscular process controlling posture (GO:0050884)2.65729620
109NADPH regeneration (GO:0006740)2.64391949
110positive regulation of membrane potential (GO:0045838)2.64175746
111negative regulation of dendrite morphogenesis (GO:0050774)2.64006958
112acylglycerol catabolic process (GO:0046464)2.63922916
113neutral lipid catabolic process (GO:0046461)2.63922916
114regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.63818651
115long-term memory (GO:0007616)2.63078171
116tricarboxylic acid metabolic process (GO:0072350)2.62156901
117trivalent inorganic cation transport (GO:0072512)2.62142809
118ferric iron transport (GO:0015682)2.62142809
119ATP biosynthetic process (GO:0006754)2.61944533
120negative regulation of calcium ion transmembrane transport (GO:1903170)2.61579939
121negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.61579939
122cyclooxygenase pathway (GO:0019371)2.59600858
123nitrogen cycle metabolic process (GO:0071941)2.59119291
124positive regulation of Rho protein signal transduction (GO:0035025)2.59064150
125endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.58980466
126neuron recognition (GO:0008038)2.58924175
127negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.58100794
128GDP-mannose metabolic process (GO:0019673)2.57747695
129regulation of excitatory postsynaptic membrane potential (GO:0060079)2.57094884
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56508724
131negative regulation of necroptotic process (GO:0060546)2.56436424
132protein neddylation (GO:0045116)2.55723128
133detection of calcium ion (GO:0005513)2.54768098
134platelet aggregation (GO:0070527)2.54184979
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54031982
136proton transport (GO:0015992)2.53885051
137positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.53744527
138positive regulation of lamellipodium assembly (GO:0010592)2.53263151
139ceramide catabolic process (GO:0046514)2.53121813
140regulation of necrotic cell death (GO:0010939)2.52936762
141regulation of protein localization to plasma membrane (GO:1903076)2.51959842
142transmission of nerve impulse (GO:0019226)2.51441852
143hydrogen transport (GO:0006818)2.51305789
144regulation of dendritic spine morphogenesis (GO:0061001)2.50905106
145cellular response to epinephrine stimulus (GO:0071872)2.49700349
146urea cycle (GO:0000050)2.49626497
147platelet degranulation (GO:0002576)2.49590366
148deoxyribonucleotide biosynthetic process (GO:0009263)2.48908183
149positive regulation of neurotransmitter transport (GO:0051590)2.48386009
150fibroblast migration (GO:0010761)2.48298061
151regulation of necroptotic process (GO:0060544)2.47916935
152oxaloacetate metabolic process (GO:0006107)2.47794674
153positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.47738670
154deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.47502404
155positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.47413545
156dendritic spine morphogenesis (GO:0060997)2.47371255
157positive regulation of endothelial cell apoptotic process (GO:2000353)2.47325405
158detection of temperature stimulus involved in sensory perception (GO:0050961)2.47202877
159detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.47202877
160long-term synaptic potentiation (GO:0060291)2.46279601
161regulation of postsynaptic membrane potential (GO:0060078)2.45781444
162positive regulation of cellular response to insulin stimulus (GO:1900078)2.45659976
163positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.45161606
164regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.45161606
165glucose catabolic process (GO:0006007)2.44434483
166substantia nigra development (GO:0021762)2.44250573
167protoporphyrinogen IX biosynthetic process (GO:0006782)2.44239177
168regulation of cell communication by electrical coupling (GO:0010649)2.44048503
169positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43614675
170regulation of synaptic plasticity (GO:0048167)2.41858235
171muscle cell migration (GO:0014812)2.41320232
172response to histamine (GO:0034776)2.40895412
173calcium ion-dependent exocytosis (GO:0017156)2.40684925
174localization within membrane (GO:0051668)2.40638766
175apoptotic cell clearance (GO:0043277)2.40485490
176mitochondrial calcium ion homeostasis (GO:0051560)2.40413441
177regulation of dopamine metabolic process (GO:0042053)2.40228286
178regulation of catecholamine metabolic process (GO:0042069)2.40228286
179cortical actin cytoskeleton organization (GO:0030866)2.39727302
180protein targeting to plasma membrane (GO:0072661)2.39007954
181regulation of neurotransmitter secretion (GO:0046928)2.38871330
182regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.37452353
183response to amphetamine (GO:0001975)2.37136213
184negative regulation of microtubule polymerization (GO:0031115)2.37030417
185cellular copper ion homeostasis (GO:0006878)2.36901073
186vesicle coating (GO:0006901)2.36714223
187positive regulation of neurotransmitter secretion (GO:0001956)2.36399564
188prepulse inhibition (GO:0060134)2.36033249
189UV protection (GO:0009650)2.33142774
190negative regulation of cell size (GO:0045792)2.32181165
191epithelial cell-cell adhesion (GO:0090136)2.30834717
192mitochondrial fusion (GO:0008053)2.30185047
193cytoskeletal anchoring at plasma membrane (GO:0007016)2.29362362
194positive regulation of lamellipodium organization (GO:1902745)2.29191528
195positive regulation of insulin receptor signaling pathway (GO:0046628)2.28616145
196clathrin coat assembly (GO:0048268)2.28367825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68202969
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.85588848
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.51805615
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12758988
5CLOCK_20551151_ChIP-Seq_293T_Human3.12615273
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11927525
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09917441
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.96305798
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91789166
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73470672
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66451343
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63589013
13TAF15_26573619_Chip-Seq_HEK293_Human2.62994041
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60509780
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58292333
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56807401
17GBX2_23144817_ChIP-Seq_PC3_Human2.51240152
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51115455
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49515180
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44313365
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44313365
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40832740
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38705040
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37907217
25REST_21632747_ChIP-Seq_MESCs_Mouse2.37508526
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.33103742
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27825397
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24817067
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.17681954
30ESR2_21235772_ChIP-Seq_MCF-7_Human2.10682526
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.10382412
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.05133437
33REST_18959480_ChIP-ChIP_MESCs_Mouse2.00221327
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.89968241
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.87923048
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84451723
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.83862468
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82342960
39AR_21572438_ChIP-Seq_LNCaP_Human1.79519622
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.78190571
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.77120942
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72879950
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71939533
44DROSHA_22980978_ChIP-Seq_HELA_Human1.69743890
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69545419
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.68496063
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68259296
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66764450
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.63899106
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63364959
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62993725
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62747532
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.62716420
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62427565
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58056768
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57915803
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57656967
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56564421
59RACK7_27058665_Chip-Seq_MCF-7_Human1.51840538
60* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51796955
61* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50975995
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.50904657
63* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48685704
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48638770
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48399104
66ZNF274_21170338_ChIP-Seq_K562_Hela1.48355182
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47933051
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.47578841
69P300_19829295_ChIP-Seq_ESCs_Human1.47470552
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47048997
71* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46253712
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45860597
73TFEB_21752829_ChIP-Seq_HELA_Human1.43515491
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.42628632
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41182532
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39261112
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38801066
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37896993
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.37002876
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35507701
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35295944
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33648451
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32478689
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32155160
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31219096
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.31218695
87TRIM28_21343339_ChIP-Seq_HEK293_Human1.30305342
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30274732
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.29061472
90TBX5_21415370_ChIP-Seq_HL-1_Mouse1.28203607
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27153974
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.24653249
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23715426
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23715426
95SMAD4_21799915_ChIP-Seq_A2780_Human1.23616340
96LXR_22292898_ChIP-Seq_THP-1_Human1.23184395
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23096544
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22634886
99VDR_22108803_ChIP-Seq_LS180_Human1.20974757
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20971491
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20799831
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18156158
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17493033
104* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.17444480
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17152457
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16785814
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16430478
108ESR1_21235772_ChIP-Seq_MCF-7_Human1.16184566
109ZNF263_19887448_ChIP-Seq_K562_Human1.16151653
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15191520
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14705646
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13219343
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12120261
114AR_25329375_ChIP-Seq_VCAP_Human1.11694383
115EOMES_21245162_ChIP-Seq_HESCs_Human1.11347144
116ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11292966
117BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11172945
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.10955915
119TBX20_22080862_ChIP-Seq_HEART_Mouse1.10955915
120RUNX1_22412390_ChIP-Seq_EML_Mouse1.09873406
121CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09659251
122ER_23166858_ChIP-Seq_MCF-7_Human1.09531506
123ATF3_27146783_Chip-Seq_COLON_Human1.09319283
124NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08454464
125TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.06474471
126OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06260357
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.05959861
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05774388
129* TET1_21490601_ChIP-Seq_MESCs_Mouse1.05660956
130SMAD3_21741376_ChIP-Seq_EPCs_Human1.04827691
131TET1_21451524_ChIP-Seq_MESCs_Mouse1.04770338
132ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04245301
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04226769
134* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04060035
135* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02685554
136TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02563302
137DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02524142
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02434294
139AR_21909140_ChIP-Seq_LNCAP_Human1.02011118
140* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01666329
141JUN_21703547_ChIP-Seq_K562_Human1.00978331
142MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00125383
143EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98929526
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.97487854
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97142717
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.96193903
147PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95248119
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95181456
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94711842
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94671814
151RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94485062
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.94183477
153KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94055484
154GATA1_19941826_ChIP-Seq_K562_Human0.93670024
155SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93597182
156MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93244146
157MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93128361
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93037692
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92994722
160WT1_19549856_ChIP-ChIP_CCG9911_Human0.92682399
161LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92039817
162EP300_21415370_ChIP-Seq_HL-1_Mouse0.91643650
163CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91275469
164PRDM14_20953172_ChIP-Seq_ESCs_Human0.91197270
165FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90687709
166P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90350868
167TP53_18474530_ChIP-ChIP_U2OS_Human0.89357154
168BCAT_22108803_ChIP-Seq_LS180_Human0.88175400
169FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87649578
170MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86901034
171MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85926406
172RNF2_27304074_Chip-Seq_NSC_Mouse0.83489385
173POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82522227
174CTCF_27219007_Chip-Seq_Bcells_Human0.80477354
175SMAD_19615063_ChIP-ChIP_OVARY_Human0.79079387
176* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77024248
177BP1_19119308_ChIP-ChIP_Hs578T_Human0.74425843
178TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.74228255
179FLI1_21867929_ChIP-Seq_TH2_Mouse0.74157155
180NR3C1_21868756_ChIP-Seq_MCF10A_Human0.73745667
181* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73506055
182CBP_20019798_ChIP-Seq_JUKART_Human0.72864188
183IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.72864188
184RUNX2_22187159_ChIP-Seq_PCA_Human0.71282074
185ZNF217_24962896_ChIP-Seq_MCF-7_Human0.70839619
186CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70839384
187SMAD4_21741376_ChIP-Seq_EPCs_Human0.70553270
188NANOG_19829295_ChIP-Seq_ESCs_Human0.69621536
189SOX2_19829295_ChIP-Seq_ESCs_Human0.69621536
190SOX2_20726797_ChIP-Seq_SW620_Human0.68231865
191FUS_26573619_Chip-Seq_HEK293_Human0.67878426
192TP53_20018659_ChIP-ChIP_R1E_Mouse0.66850583

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.51830147
2MP0003880_abnormal_central_pattern4.38624862
3MP0004270_analgesia3.83032846
4MP0003705_abnormal_hypodermis_morpholog3.58185837
5MP0002822_catalepsy3.33929664
6MP0003635_abnormal_synaptic_transmissio3.28561797
7MP0001968_abnormal_touch/_nociception3.27799172
8MP0009745_abnormal_behavioral_response2.97376774
9MP0002064_seizures2.86095678
10MP0002736_abnormal_nociception_after2.85359453
11MP0002734_abnormal_mechanical_nocicepti2.83330105
12MP0003191_abnormal_cellular_cholesterol2.74396964
13MP0002877_abnormal_melanocyte_morpholog2.68733721
14MP0005464_abnormal_platelet_physiology2.64229380
15MP0002063_abnormal_learning/memory/cond2.63770848
16MP0004185_abnormal_adipocyte_glucose2.63449624
17MP0002735_abnormal_chemical_nociception2.61448986
18MP0005423_abnormal_somatic_nervous2.60812853
19MP0005451_abnormal_body_composition2.59802728
20MP0009046_muscle_twitch2.59621763
21MP0000343_altered_response_to2.50787219
22MP0005670_abnormal_white_adipose2.50235995
23MP0003566_abnormal_cell_adhesion2.47448477
24MP0008260_abnormal_autophagy2.44376729
25MP0005666_abnormal_adipose_tissue2.41420233
26MP0006276_abnormal_autonomic_nervous2.40914753
27MP0002572_abnormal_emotion/affect_behav2.37220896
28MP0003186_abnormal_redox_activity2.35085086
29MP0001440_abnormal_grooming_behavior2.34557112
30MP0001905_abnormal_dopamine_level2.31038782
31MP0002272_abnormal_nervous_system2.29547885
32MP0009840_abnormal_foam_cell2.26271596
33MP0002733_abnormal_thermal_nociception2.20861894
34MP0008438_abnormal_cutaneous_collagen2.19385528
35MP0001970_abnormal_pain_threshold2.16777199
36MP0001529_abnormal_vocalization2.16217075
37MP0004233_abnormal_muscle_weight1.99917117
38MP0003329_amyloid_beta_deposits1.97227048
39MP0001849_ear_inflammation1.95093958
40MP0009379_abnormal_foot_pigmentation1.94189713
41MP0001501_abnormal_sleep_pattern1.91205187
42MP0001486_abnormal_startle_reflex1.85500838
43MP0002837_dystrophic_cardiac_calcinosis1.85101157
44MP0000749_muscle_degeneration1.83590641
45MP0004130_abnormal_muscle_cell1.83017284
46MP0005375_adipose_tissue_phenotype1.79560943
47MP0002909_abnormal_adrenal_gland1.75799072
48MP0002971_abnormal_brown_adipose1.75749283
49MP0002067_abnormal_sensory_capabilities1.73338130
50MP0001958_emphysema1.71369991
51MP0010386_abnormal_urinary_bladder1.67603830
52MP0000747_muscle_weakness1.67031792
53MP0004924_abnormal_behavior1.65699671
54MP0005386_behavior/neurological_phenoty1.65699671
55MP0000013_abnormal_adipose_tissue1.57883657
56MP0010352_gastrointestinal_tract_polyps1.50752688
57MP0005257_abnormal_intraocular_pressure1.49335906
58MP0003806_abnormal_nucleotide_metabolis1.48204260
59MP0003828_pulmonary_edema1.45236951
60MP0003221_abnormal_cardiomyocyte_apopto1.40521317
61MP0004858_abnormal_nervous_system1.40116129
62MP0002557_abnormal_social/conspecific_i1.39864329
63MP0004142_abnormal_muscle_tone1.37310018
64MP0001984_abnormal_olfaction1.36917255
65MP0005501_abnormal_skin_physiology1.35871651
66MP0002184_abnormal_innervation1.34086366
67MP0000751_myopathy1.32809085
68MP0003879_abnormal_hair_cell1.32785589
69MP0009780_abnormal_chondrocyte_physiolo1.32576621
70MP0002796_impaired_skin_barrier1.32470525
71MP0003279_aneurysm1.32021225
72MP0003453_abnormal_keratinocyte_physiol1.31899033
73MP0003091_abnormal_cell_migration1.28335350
74MP0004811_abnormal_neuron_physiology1.27791347
75MP0001542_abnormal_bone_strength1.26426531
76MP0000858_altered_metastatic_potential1.26344647
77MP0000604_amyloidosis1.25719329
78MP0003633_abnormal_nervous_system1.23622513
79MP0004087_abnormal_muscle_fiber1.23621956
80MP0005535_abnormal_body_temperature1.23163184
81MP0002066_abnormal_motor_capabilities/c1.20830915
82MP0005167_abnormal_blood-brain_barrier1.19886515
83MP0008569_lethality_at_weaning1.18848077
84MP0003656_abnormal_erythrocyte_physiolo1.18188654
85MP0004084_abnormal_cardiac_muscle1.17057333
86MP0003868_abnormal_feces_composition1.16800330
87MP0001727_abnormal_embryo_implantation1.16752688
88MP0000920_abnormal_myelination1.15192306
89MP0000003_abnormal_adipose_tissue1.14686702
90MP0004147_increased_porphyrin_level1.10172224
91MP0005584_abnormal_enzyme/coenzyme_acti1.09605650
92MP0000759_abnormal_skeletal_muscle1.09074718
93MP0005275_abnormal_skin_tensile1.08179465
94MP0000778_abnormal_nervous_system1.06641273
95MP0003122_maternal_imprinting1.06274889
96MP0006138_congestive_heart_failure1.05788139
97MP0009115_abnormal_fat_cell1.05220910
98MP0004272_abnormal_basement_membrane1.03980642
99MP0002876_abnormal_thyroid_physiology1.03025945
100MP0008872_abnormal_physiological_respon1.02487722
101MP0002882_abnormal_neuron_morphology1.02285150
102MP0005023_abnormal_wound_healing0.98495282
103MP0001243_abnormal_dermal_layer0.98021174
104MP0004885_abnormal_endolymph0.98016203
105MP0002896_abnormal_bone_mineralization0.97843786
106MP0008874_decreased_physiological_sensi0.97600229
107MP0005330_cardiomyopathy0.97491321
108MP0000955_abnormal_spinal_cord0.97384880
109MP0003075_altered_response_to0.97033533
110MP0002970_abnormal_white_adipose0.96477892
111MP0003631_nervous_system_phenotype0.96371321
112MP0005646_abnormal_pituitary_gland0.95659976
113MP0004215_abnormal_myocardial_fiber0.94972586
114MP0002269_muscular_atrophy0.93220275
115MP0005645_abnormal_hypothalamus_physiol0.92830880
116MP0001661_extended_life_span0.91936010
117MP0008004_abnormal_stomach_pH0.91659154
118MP0003303_peritoneal_inflammation0.90883769
119MP0004043_abnormal_pH_regulation0.88604006
120MP0004484_altered_response_of0.87721790
121MP0000230_abnormal_systemic_arterial0.87656022
122MP0004085_abnormal_heartbeat0.87406724
123MP0003690_abnormal_glial_cell0.86444826
124MP0003638_abnormal_response/metabolism_0.85199373
125MP0001664_abnormal_digestion0.84749262
126MP0002998_abnormal_bone_remodeling0.84617208
127MP0005623_abnormal_meninges_morphology0.84395770
128MP0006054_spinal_hemorrhage0.83625161
129MP0002229_neurodegeneration0.83190467
130MP0002295_abnormal_pulmonary_circulatio0.82846442
131* MP0005084_abnormal_gallbladder_morpholo0.81829678
132MP0002069_abnormal_eating/drinking_beha0.80968106
133MP0003634_abnormal_glial_cell0.80930681
134MP0003195_calcinosis0.79694292
135MP0010630_abnormal_cardiac_muscle0.79612047
136MP0005621_abnormal_cell_physiology0.79034500
137MP0004742_abnormal_vestibular_system0.78351817
138MP0002332_abnormal_exercise_endurance0.77179796
139MP0001544_abnormal_cardiovascular_syste0.76949122
140MP0005385_cardiovascular_system_phenoty0.76949122
141MP0003448_altered_tumor_morphology0.75477054
142MP0000358_abnormal_cell_content/0.75373261
143MP0003300_gastrointestinal_ulcer0.74692642
144MP0002090_abnormal_vision0.74342323
145MP0003724_increased_susceptibility_to0.73444239
146MP0005620_abnormal_muscle_contractility0.73220244
147MP0005164_abnormal_response_to0.72797018
148MP0004947_skin_inflammation0.72145542
149MP0002118_abnormal_lipid_homeostasis0.71874884
150MP0002972_abnormal_cardiac_muscle0.71459898
151MP0010234_abnormal_vibrissa_follicle0.71070352
152MP0004036_abnormal_muscle_relaxation0.70229240
153MP0000249_abnormal_blood_vessel0.70113586
154MP0006035_abnormal_mitochondrial_morpho0.69510822
155MP0005384_cellular_phenotype0.69324533
156MP0004510_myositis0.68799674
157MP0000750_abnormal_muscle_regeneration0.68357994
158MP0005595_abnormal_vascular_smooth0.67849741
159MP0005448_abnormal_energy_balance0.67748220
160MP0005409_darkened_coat_color0.67575217
161MP0005165_increased_susceptibility_to0.67480067
162MP0004883_abnormal_blood_vessel0.67340794
163MP0001502_abnormal_circadian_rhythm0.67186116
164MP0006036_abnormal_mitochondrial_physio0.63615044
165MP0004145_abnormal_muscle_electrophysio0.61772478
166MP0001986_abnormal_taste_sensitivity0.59802057
167MP0001188_hyperpigmentation0.59417772
168MP0001765_abnormal_ion_homeostasis0.58357837
169MP0005166_decreased_susceptibility_to0.58147606
170MP0005058_abnormal_lysosome_morphology0.57224852
171MP0002152_abnormal_brain_morphology0.56583425
172MP0005171_absent_coat_pigmentation0.55395382
173MP0003137_abnormal_impulse_conducting0.55107284

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.56482239
2Focal motor seizures (HP:0011153)5.29994796
3Acute necrotizing encephalopathy (HP:0006965)4.07639102
4Atonic seizures (HP:0010819)3.95772453
5Vertebral compression fractures (HP:0002953)3.85295564
6Abnormal mitochondria in muscle tissue (HP:0008316)3.73506781
7Focal seizures (HP:0007359)3.66522599
8Mitochondrial inheritance (HP:0001427)3.63945113
9Progressive macrocephaly (HP:0004481)3.53618822
10Acute encephalopathy (HP:0006846)3.40876913
11Epileptic encephalopathy (HP:0200134)3.38385896
12Abnormality of liposaccharide metabolism (HP:0010968)3.37101345
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.37101345
14Abnormality of glycolipid metabolism (HP:0010969)3.37101345
15Visual hallucinations (HP:0002367)3.31448506
16Absence seizures (HP:0002121)3.24367486
17Axonal loss (HP:0003447)3.18319392
18Hepatocellular necrosis (HP:0001404)3.14682405
19Pheochromocytoma (HP:0002666)3.12688108
20Distal lower limb muscle weakness (HP:0009053)3.01628814
21Generalized tonic-clonic seizures (HP:0002069)3.01292204
22Increased mean platelet volume (HP:0011877)2.99626801
23Neuroendocrine neoplasm (HP:0100634)2.98452429
24Retinal dysplasia (HP:0007973)2.97653710
25Anxiety (HP:0000739)2.97643560
26Purpura (HP:0000979)2.96088358
27Distal lower limb amyotrophy (HP:0008944)2.95459132
28Increased CSF lactate (HP:0002490)2.92383230
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.88337964
30Osteolytic defects of the hand bones (HP:0009699)2.88337964
31Neurofibrillary tangles (HP:0002185)2.85372701
32Dialeptic seizures (HP:0011146)2.85300620
33Increased connective tissue (HP:0009025)2.81512768
34Increased hepatocellular lipid droplets (HP:0006565)2.79622072
35Loss of speech (HP:0002371)2.75739592
36Polycythemia (HP:0001901)2.72471713
37Supranuclear gaze palsy (HP:0000605)2.72361460
38Abnormality of skeletal muscle fiber size (HP:0012084)2.72278770
39Abnormal platelet volume (HP:0011876)2.72019622
40Protrusio acetabuli (HP:0003179)2.70581950
41Limb dystonia (HP:0002451)2.66005727
42Abnormal eating behavior (HP:0100738)2.64715282
43Hepatic necrosis (HP:0002605)2.58013448
44Abnormality of binocular vision (HP:0011514)2.57453418
45Diplopia (HP:0000651)2.57453418
46Lipid accumulation in hepatocytes (HP:0006561)2.54689495
47Petechiae (HP:0000967)2.53799726
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.50893240
49Increased variability in muscle fiber diameter (HP:0003557)2.49513637
50Febrile seizures (HP:0002373)2.49229656
51Nemaline bodies (HP:0003798)2.48599740
52Polyphagia (HP:0002591)2.45854923
53Menorrhagia (HP:0000132)2.45401268
54Renal Fanconi syndrome (HP:0001994)2.45070950
55Progressive cerebellar ataxia (HP:0002073)2.43991745
56Dysostosis multiplex (HP:0000943)2.43347396
57Parakeratosis (HP:0001036)2.39779376
58Progressive inability to walk (HP:0002505)2.39681731
59Increased intramyocellular lipid droplets (HP:0012240)2.39650403
60Centrally nucleated skeletal muscle fibers (HP:0003687)2.37486818
61Torticollis (HP:0000473)2.36811365
62Broad-based gait (HP:0002136)2.35699722
63Cerebral hemorrhage (HP:0001342)2.33019208
64Rhabdomyolysis (HP:0003201)2.32150694
65Myotonia (HP:0002486)2.31591851
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.31086029
67Insomnia (HP:0100785)2.30820822
68Mutism (HP:0002300)2.29146071
69Cerebral edema (HP:0002181)2.29049140
70Papilledema (HP:0001085)2.29008813
71Amblyopia (HP:0000646)2.28415291
72Ankle clonus (HP:0011448)2.27606985
73Spinal rigidity (HP:0003306)2.27163293
74Diminished motivation (HP:0000745)2.26658046
75Cerebral inclusion bodies (HP:0100314)2.26545396
76Lower limb amyotrophy (HP:0007210)2.26513800
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26482626
78Apathy (HP:0000741)2.26300913
79Focal dystonia (HP:0004373)2.25201934
80Prolonged bleeding time (HP:0003010)2.24679492
81Muscle fiber inclusion bodies (HP:0100299)2.22512536
82Action tremor (HP:0002345)2.22502860
83Dysmetria (HP:0001310)2.21543013
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21282383
85Multiple enchondromatosis (HP:0005701)2.18956480
86Delusions (HP:0000746)2.18670296
87Craniofacial dystonia (HP:0012179)2.18398545
88Optic disc pallor (HP:0000543)2.17350781
89Depression (HP:0000716)2.15073490
90Type 1 muscle fiber predominance (HP:0003803)2.14807601
91Abnormal pupillary function (HP:0007686)2.14711688
92Poor suck (HP:0002033)2.13343865
93Respiratory failure (HP:0002878)2.11546290
94Premature rupture of membranes (HP:0001788)2.11393043
95Upper limb amyotrophy (HP:0009129)2.10787919
96Distal upper limb amyotrophy (HP:0007149)2.10787919
97Neck muscle weakness (HP:0000467)2.10088671
98Abnormality of the axillary hair (HP:0100134)2.09107841
99Abnormality of secondary sexual hair (HP:0009888)2.09107841
100Poor eye contact (HP:0000817)2.08600714
101Increased muscle lipid content (HP:0009058)2.08178734
102Back pain (HP:0003418)2.06916440
103Type II lissencephaly (HP:0007260)2.06634710
104Hyperparathyroidism (HP:0000843)2.05534982
105Truncal ataxia (HP:0002078)2.05048203
106Leukodystrophy (HP:0002415)2.04440132
107Myoglobinuria (HP:0002913)2.03923218
108Abnormal gallbladder physiology (HP:0012438)2.03892204
109Cholecystitis (HP:0001082)2.03892204
110Hyperventilation (HP:0002883)2.03017719
111Systemic lupus erythematosus (HP:0002725)2.02788353
112Lactic acidosis (HP:0003128)2.01561427
113Vascular tortuosity (HP:0004948)2.01352133
114Myocardial infarction (HP:0001658)2.01041784
115Growth hormone excess (HP:0000845)2.00332626
116Hemiparesis (HP:0001269)2.00330759
117Exercise intolerance (HP:0003546)1.99673328
118Ankle contracture (HP:0006466)1.99051910
119Hyperacusis (HP:0010780)1.99017223
120Abnormal hemoglobin (HP:0011902)1.98057335
121Hypothermia (HP:0002045)1.97648758
122Upper limb muscle weakness (HP:0003484)1.96588143
123Progressive neurologic deterioration (HP:0002344)1.96497159
124Hepatosplenomegaly (HP:0001433)1.94959039
125Ventricular fibrillation (HP:0001663)1.94806157
126Psychosis (HP:0000709)1.94803039
127Increased cerebral lipofuscin (HP:0011813)1.94353704
128Mitral stenosis (HP:0001718)1.92952885
129Neuronal loss in central nervous system (HP:0002529)1.92811704
130Abnormality of the Achilles tendon (HP:0005109)1.92577907
131Subcapsular cataract (HP:0000523)1.91140546
132Hypertriglyceridemia (HP:0002155)1.90915166
133Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90127438
134Muscle hypertrophy of the lower extremities (HP:0008968)1.89954874
135Achilles tendon contracture (HP:0001771)1.88608582
136X-linked dominant inheritance (HP:0001423)1.88587702
137Papillary thyroid carcinoma (HP:0002895)1.88164246
138Agitation (HP:0000713)1.87179260
139Foot dorsiflexor weakness (HP:0009027)1.86596162
140Arterial tortuosity (HP:0005116)1.86516814
141Delayed gross motor development (HP:0002194)1.85377214
142Cholelithiasis (HP:0001081)1.83960418
143Failure to thrive in infancy (HP:0001531)1.82408657
144Hyperphosphaturia (HP:0003109)1.82332905
145Oligomenorrhea (HP:0000876)1.81705415
146Sensory axonal neuropathy (HP:0003390)1.81147712
147Exercise-induced myalgia (HP:0003738)1.81092763
148Increased serum pyruvate (HP:0003542)1.79053426
149Acanthosis nigricans (HP:0000956)1.78908100
1503-Methylglutaconic aciduria (HP:0003535)1.78688854
151Amyloidosis (HP:0011034)1.78484508
152Hyporeflexia of lower limbs (HP:0002600)1.77775828
153Abnormal social behavior (HP:0012433)1.77510739
154Impaired social interactions (HP:0000735)1.77510739
155Mucopolysacchariduria (HP:0008155)1.76797193
156Urinary glycosaminoglycan excretion (HP:0003541)1.76797193
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76369262
158Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76369262
159Abnormality of polysaccharide metabolism (HP:0011012)1.76369262
160Bundle branch block (HP:0011710)1.75158283
161Rapidly progressive (HP:0003678)1.74969724
162Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74484511
163Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74484511
164Neoplasm of the peripheral nervous system (HP:0100007)1.74337041
165Bulbar palsy (HP:0001283)1.74316732
166Congenital ichthyosiform erythroderma (HP:0007431)1.73193674
167Ventricular tachycardia (HP:0004756)1.73098954
168Abnormal cartilage morphology (HP:0002763)1.72992730
169Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70708879
170Tetraparesis (HP:0002273)1.70484390
171Fasciculations (HP:0002380)1.70367675
172Hand muscle atrophy (HP:0009130)1.70101026
173Muscle fiber splitting (HP:0003555)1.69884142
174Calf muscle hypertrophy (HP:0008981)1.69666981
175Cervical subluxation (HP:0003308)1.69385159
176Frequent falls (HP:0002359)1.68873675
177Intention tremor (HP:0002080)1.68240341
178Disinhibition (HP:0000734)1.68179154
179Personality changes (HP:0000751)1.67901578
180Inability to walk (HP:0002540)1.67750767
181Resting tremor (HP:0002322)1.67365424
182Emotional lability (HP:0000712)1.66448941
183Incomplete penetrance (HP:0003829)1.66323503
184Autoamputation (HP:0001218)1.65781501
185Difficulty climbing stairs (HP:0003551)1.65649952
186Generalized myoclonic seizures (HP:0002123)1.64213596
187Sudden death (HP:0001699)1.64120724
188Insidious onset (HP:0003587)1.64088648
189Termporal pattern (HP:0011008)1.64088648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.42368124
2EPHA43.21134933
3NTRK33.05814901
4MAP3K92.92318978
5EIF2AK12.85014535
6ARAF2.63105260
7MARK12.41632489
8CASK2.41632441
9MINK12.40597707
10TESK22.39630908
11TRIB32.32428656
12IRAK32.23193085
13DAPK22.18199751
14NME12.13888044
15MAP2K72.11587620
16RIPK42.07120416
17PBK2.06986022
18KSR22.00406707
19NTRK11.97714709
20DMPK1.96001088
21MAP3K41.95569226
22RIPK11.92896168
23BCR1.81956895
24MAP2K41.80252512
25TTN1.66612851
26GRK51.64435815
27LIMK11.61503260
28ABL21.54524966
29MAP3K61.54107013
30PAK41.51636329
31PAK61.50195490
32ILK1.49194195
33CDK191.48943736
34PDGFRA1.48058279
35OXSR11.46281858
36PRPF4B1.44490154
37CDK51.33906241
38PLK21.30913526
39KDR1.30315631
40BMX1.28699522
41CAMKK21.24879918
42TAOK21.24465008
43DAPK11.23158634
44KSR11.22548353
45SIK31.22390283
46MAP2K31.21528275
47STK391.21503808
48TGFBR21.21104992
49PTK21.17684935
50MAPK131.17163425
51MAP3K21.16758458
52NTRK21.15442839
53DAPK31.14033070
54PHKG11.09689896
55PHKG21.09689896
56MAP3K131.09363233
57FES1.08980369
58CAMK2A1.08779018
59EPHB11.07621266
60UHMK11.03634369
61DDR21.03562912
62NEK91.03090501
63PRKCG1.02954800
64CAMK2B1.01636931
65TESK10.99694506
66MAP3K30.99665884
67MYLK0.97357633
68GRK70.96744653
69CDK140.96313160
70MAP2K10.95096759
71LRRK20.95003589
72PAK30.92632465
73PTK2B0.90877834
74EPHA20.89668092
75MST1R0.87626079
76PAK20.85524058
77SIK10.85131942
78CDK180.84110358
79MAPKAPK50.83295415
80CAMKK10.82822437
81BMPR20.82647164
82TNIK0.81581510
83NME20.81226784
84WNK40.81062521
85PRKCE0.81032945
86PRKD30.80266772
87CDK150.77809290
88LMTK20.75823855
89ADRBK10.75719856
90CAMK2D0.75015416
91CSNK1G20.74332329
92TIE10.73672209
93PAK10.73283854
94CAMK2G0.72348462
95MOS0.70913034
96MAP3K110.70133559
97AKT30.69762534
98PNCK0.69463783
99MAP3K10.68664487
100PKN20.68447406
101CSNK1G30.67449863
102CDK11A0.66548635
103SIK20.65826525
104SGK2230.62957343
105SGK4940.62957343
106RAF10.62224698
107BMPR1B0.62115471
108TYK20.61413839
109ERN10.60982101
110MAPK120.60345767
111STK160.60151956
112MAP3K50.60037646
113BRAF0.59921612
114MAPKAPK30.59737418
115RET0.57194396
116BCKDK0.57124670
117ZAP700.56640545
118ROCK20.54978922
119ICK0.54756409
120FGR0.53409454
121ADRBK20.53269843
122CAMK10.51539280
123TAOK10.50941601
124TBK10.50616860
125AKT20.50482763
126DYRK20.50070346
127TYRO30.49564769
128NEK10.49561623
129EPHB20.47389538
130LATS20.46893422
131ERBB40.43581567
132RPS6KA20.43256612
133MST40.43145609
134PRKD10.42942243
135FER0.42363705
136PDPK10.42116710
137FGFR40.41664818
138ROCK10.40144424
139PRKACA0.40137868
140MAP2K60.39720185
141PRKCZ0.38742796
142SCYL20.38526818
143FYN0.37965566
144PIM20.37558847
145PDK20.35914761
146PDK40.35813013
147PDK30.35813013
148ALK0.30254948
149OBSCN0.29784482
150PTK60.29743941
151JAK10.29648109

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.87285571
2Parkinsons disease_Homo sapiens_hsa050123.28904130
3Synaptic vesicle cycle_Homo sapiens_hsa047213.21277058
4Alzheimers disease_Homo sapiens_hsa050102.71631144
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.66516092
6Collecting duct acid secretion_Homo sapiens_hsa049662.64696151
7Nicotine addiction_Homo sapiens_hsa050332.59949874
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.45678345
9GABAergic synapse_Homo sapiens_hsa047272.28774636
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.23359776
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.18218271
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.18118960
13Cardiac muscle contraction_Homo sapiens_hsa042602.16077547
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12915474
15Vibrio cholerae infection_Homo sapiens_hsa051102.10376973
16Huntingtons disease_Homo sapiens_hsa050162.03486726
17Morphine addiction_Homo sapiens_hsa050321.90595743
18Circadian entrainment_Homo sapiens_hsa047131.89038482
19Olfactory transduction_Homo sapiens_hsa047401.88342157
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83612738
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83225352
22Glutamatergic synapse_Homo sapiens_hsa047241.79582580
23Amphetamine addiction_Homo sapiens_hsa050311.74683818
24Long-term potentiation_Homo sapiens_hsa047201.74664145
25Dopaminergic synapse_Homo sapiens_hsa047281.74166229
26Protein export_Homo sapiens_hsa030601.72369245
27PPAR signaling pathway_Homo sapiens_hsa033201.71503281
28Other glycan degradation_Homo sapiens_hsa005111.70102124
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68146690
30Serotonergic synapse_Homo sapiens_hsa047261.62296506
31Carbon metabolism_Homo sapiens_hsa012001.60299510
32Gastric acid secretion_Homo sapiens_hsa049711.60023996
33Phenylalanine metabolism_Homo sapiens_hsa003601.55662278
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.53860649
35Shigellosis_Homo sapiens_hsa051311.52737886
36Salivary secretion_Homo sapiens_hsa049701.50897782
37Insulin secretion_Homo sapiens_hsa049111.48259101
38Cholinergic synapse_Homo sapiens_hsa047251.46623459
39Cocaine addiction_Homo sapiens_hsa050301.41309334
40Pentose phosphate pathway_Homo sapiens_hsa000301.40021611
41Ribosome_Homo sapiens_hsa030101.38179201
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36522661
43Renin secretion_Homo sapiens_hsa049241.35914793
44Long-term depression_Homo sapiens_hsa047301.32805186
45* SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31924655
46Galactose metabolism_Homo sapiens_hsa000521.30721608
47Taste transduction_Homo sapiens_hsa047421.27352915
48Biosynthesis of amino acids_Homo sapiens_hsa012301.22533218
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20181632
50Rheumatoid arthritis_Homo sapiens_hsa053231.18668520
51AMPK signaling pathway_Homo sapiens_hsa041521.17729295
52Insulin signaling pathway_Homo sapiens_hsa049101.14419163
53Glutathione metabolism_Homo sapiens_hsa004801.13935397
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12510495
55Oxytocin signaling pathway_Homo sapiens_hsa049211.12372486
56Platelet activation_Homo sapiens_hsa046111.09081706
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.07833201
58Focal adhesion_Homo sapiens_hsa045101.06073814
59Fatty acid metabolism_Homo sapiens_hsa012121.06025718
60beta-Alanine metabolism_Homo sapiens_hsa004101.03644599
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03614280
62Fructose and mannose metabolism_Homo sapiens_hsa000511.02919054
63Gap junction_Homo sapiens_hsa045401.01541530
64Thyroid cancer_Homo sapiens_hsa052161.01509027
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00748849
66GnRH signaling pathway_Homo sapiens_hsa049121.00163102
67Pancreatic cancer_Homo sapiens_hsa052120.99642938
68Calcium signaling pathway_Homo sapiens_hsa040200.99075398
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98921562
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98762500
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91181215
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91127043
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91053477
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90636300
75Tyrosine metabolism_Homo sapiens_hsa003500.87468465
76Adherens junction_Homo sapiens_hsa045200.87390512
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.86832902
78Phagosome_Homo sapiens_hsa041450.86830676
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85650800
80Proteoglycans in cancer_Homo sapiens_hsa052050.84543303
81Proteasome_Homo sapiens_hsa030500.82992609
82Sulfur relay system_Homo sapiens_hsa041220.79099291
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78632717
84Pancreatic secretion_Homo sapiens_hsa049720.76759150
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76103242
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.74368065
87Folate biosynthesis_Homo sapiens_hsa007900.73218602
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73212960
89Fatty acid degradation_Homo sapiens_hsa000710.73084783
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72358257
91Tight junction_Homo sapiens_hsa045300.72211032
92Arginine and proline metabolism_Homo sapiens_hsa003300.72004034
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.71042448
94Endometrial cancer_Homo sapiens_hsa052130.70999679
95Thyroid hormone synthesis_Homo sapiens_hsa049180.69047890
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69031454
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.67704108
98Estrogen signaling pathway_Homo sapiens_hsa049150.65919044
99Dilated cardiomyopathy_Homo sapiens_hsa054140.65775825
100cAMP signaling pathway_Homo sapiens_hsa040240.65635192
101Arginine biosynthesis_Homo sapiens_hsa002200.64726559
102Choline metabolism in cancer_Homo sapiens_hsa052310.64563212
103Amoebiasis_Homo sapiens_hsa051460.64475773
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63500950
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62004489
106mTOR signaling pathway_Homo sapiens_hsa041500.61520719
107Melanogenesis_Homo sapiens_hsa049160.59596353
108Type I diabetes mellitus_Homo sapiens_hsa049400.58970984
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58853218
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58717426
111Butanoate metabolism_Homo sapiens_hsa006500.58031729
112Pyruvate metabolism_Homo sapiens_hsa006200.57304556
113Sulfur metabolism_Homo sapiens_hsa009200.56554976
114Renin-angiotensin system_Homo sapiens_hsa046140.56293405
115Sphingolipid metabolism_Homo sapiens_hsa006000.55634089
116Chronic myeloid leukemia_Homo sapiens_hsa052200.55364961
117Prion diseases_Homo sapiens_hsa050200.54131146
118Hepatitis C_Homo sapiens_hsa051600.53181469
119Axon guidance_Homo sapiens_hsa043600.52800386
120HIF-1 signaling pathway_Homo sapiens_hsa040660.52170804
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51464384
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50319737
123Phototransduction_Homo sapiens_hsa047440.48527241
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47772039
125Ras signaling pathway_Homo sapiens_hsa040140.47202591
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.46896309
127VEGF signaling pathway_Homo sapiens_hsa043700.46812152
128Acute myeloid leukemia_Homo sapiens_hsa052210.46082441
129Osteoclast differentiation_Homo sapiens_hsa043800.45813183
130ECM-receptor interaction_Homo sapiens_hsa045120.45758137
131Malaria_Homo sapiens_hsa051440.45000417
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44335309
133Peroxisome_Homo sapiens_hsa041460.44060618
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43419681
135Pertussis_Homo sapiens_hsa051330.42827631
136Nitrogen metabolism_Homo sapiens_hsa009100.42731371
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42689397
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42638104
139African trypanosomiasis_Homo sapiens_hsa051430.42143808
140Non-small cell lung cancer_Homo sapiens_hsa052230.41286071
141Endocytosis_Homo sapiens_hsa041440.41209510
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41188137
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41005397
144Glioma_Homo sapiens_hsa052140.40130598
145Regulation of autophagy_Homo sapiens_hsa041400.39381521
146Bile secretion_Homo sapiens_hsa049760.38048192
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37372085
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35632124
149Fatty acid elongation_Homo sapiens_hsa000620.35539992
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.34759480
151Rap1 signaling pathway_Homo sapiens_hsa040150.34476183
152ErbB signaling pathway_Homo sapiens_hsa040120.34198871
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33380589
154Mineral absorption_Homo sapiens_hsa049780.32852008
155Type II diabetes mellitus_Homo sapiens_hsa049300.32799535
156Salmonella infection_Homo sapiens_hsa051320.32644593
157Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30766693
158Lysosome_Homo sapiens_hsa041420.30642757
159Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26815227
160Alcoholism_Homo sapiens_hsa050340.26429457
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24783523
162Renal cell carcinoma_Homo sapiens_hsa052110.23938988
163Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22766850
164Ether lipid metabolism_Homo sapiens_hsa005650.21931207
165Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21536048
166Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21437787
167Propanoate metabolism_Homo sapiens_hsa006400.20435584
168MAPK signaling pathway_Homo sapiens_hsa040100.20176917

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