ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	heart valve formation (GO:0003188)	9.04722048
2	sphingosine metabolic process (GO:0006670)	7.24505821
3	diol metabolic process (GO:0034311)	7.01868875
4	sphingoid metabolic process (GO:0046519)	6.60120047
5	Notch signaling involved in heart development (GO:0061314)	5.72994693
6	negative regulation of mast cell activation (GO:0033004)	5.44072505
7	alanine transport (GO:0032328)	5.36484594
8	regulation of vasculogenesis (GO:2001212)	5.29655891
9	behavioral response to nicotine (GO:0035095)	5.28898682
10	regulation of penile erection (GO:0060405)	5.23152958
11	prepulse inhibition (GO:0060134)	5.22217968
12	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	5.22062566
13	lipopolysaccharide biosynthetic process (GO:0009103)	5.14106875
14	DNA methylation involved in gamete generation (GO:0043046)	5.04624874
15	negative regulation of transcription regulatory region DNA binding (GO:2000678)	4.96674614
16	endocardial cushion morphogenesis (GO:0003203)	4.96043030
17	glycerol metabolic process (GO:0006071)	4.90989802
18	neuronal action potential propagation (GO:0019227)	4.87247890
19	mesenchyme morphogenesis (GO:0072132)	4.80251127
20	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.70489620
21	L-serine transport (GO:0015825)	4.67030051
22	regulation of fever generation (GO:0031620)	4.66157590
23	piRNA metabolic process (GO:0034587)	4.63345730
24	ventricular trabecula myocardium morphogenesis (GO:0003222)	4.59969428
25	regulation of protein glycosylation (GO:0060049)	4.52473828
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.42476061
27	lipopolysaccharide metabolic process (GO:0008653)	4.41372814
28	response to gravity (GO:0009629)	4.33040899
29	negative regulation of glycoprotein biosynthetic process (GO:0010561)	4.30571508
30	cell proliferation in forebrain (GO:0021846)	4.27185245
31	regulation of meiosis I (GO:0060631)	4.23535696
32	alditol metabolic process (GO:0019400)	4.20759806
33	protein-chromophore linkage (GO:0018298)	4.19578354
34	serine transport (GO:0032329)	4.16161732
35	heart trabecula morphogenesis (GO:0061384)	4.08369419
36	negative regulation of multicellular organism growth (GO:0040015)	4.06675923
37	response to nitrosative stress (GO:0051409)	4.05559927
38	cell proliferation involved in metanephros development (GO:0072203)	3.97506039
39	regulation of heat generation (GO:0031650)	3.86705083
40	sulfation (GO:0051923)	3.83504730
41	cell proliferation involved in kidney development (GO:0072111)	3.82783002
42	cellular response to sterol (GO:0036315)	3.70699665
43	neuronal stem cell maintenance (GO:0097150)	3.67538461
44	somite development (GO:0061053)	3.61519227
45	notochord development (GO:0030903)	3.59797406
46	dendritic spine morphogenesis (GO:0060997)	3.56299138
47	tachykinin receptor signaling pathway (GO:0007217)	3.53139726
48	labyrinthine layer blood vessel development (GO:0060716)	3.47176527
49	cell-cell signaling involved in cell fate commitment (GO:0045168)	3.43216888
50	neuromuscular process controlling posture (GO:0050884)	3.41385453
51	male meiosis I (GO:0007141)	3.37705984
52	tyrosine phosphorylation of STAT protein (GO:0007260)	3.35299674
53	regulation of cilium movement (GO:0003352)	3.34358628
54	DNA deamination (GO:0045006)	3.34280610
55	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.32306251
56	sleep (GO:0030431)	3.31134143
57	somite rostral/caudal axis specification (GO:0032525)	3.25811348
58	negative regulation of telomere maintenance (GO:0032205)	3.24802841
59	trabecula morphogenesis (GO:0061383)	3.22305329
60	heme transport (GO:0015886)	3.20186804
61	regulation of translational termination (GO:0006449)	3.18029515
62	positive regulation of meiosis (GO:0045836)	3.11507934
63	sulfate transmembrane transport (GO:1902358)	3.10407792
64	negative regulation of glycoprotein metabolic process (GO:1903019)	3.06567516
65	meiosis I (GO:0007127)	3.03286239
66	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.02943699
67	aorta morphogenesis (GO:0035909)	3.01246074
68	viral protein processing (GO:0019082)	3.01223618
69	protein refolding (GO:0042026)	3.00403269
70	regulation of transcription regulatory region DNA binding (GO:2000677)	2.99415405
71	paraxial mesoderm development (GO:0048339)	2.98411329
72	developmental induction (GO:0031128)	2.97681379
73	negative regulation of inclusion body assembly (GO:0090084)	2.97487562
74	negative regulation of adenylate cyclase activity (GO:0007194)	2.96263657
75	phasic smooth muscle contraction (GO:0014821)	2.95556332
76	negative regulation of Notch signaling pathway (GO:0045746)	2.95438793
77	pharyngeal system development (GO:0060037)	2.94685374
78	cellular response to cholesterol (GO:0071397)	2.93997891
79	heart trabecula formation (GO:0060347)	2.90062445
80	positive regulation of T cell apoptotic process (GO:0070234)	2.89721354
81	serotonin metabolic process (GO:0042428)	2.87519692
82	positive regulation of meiotic cell cycle (GO:0051446)	2.86305823
83	renal system development (GO:0072001)	2.85330699
84	negative regulation of cyclase activity (GO:0031280)	2.79068246
85	adaptation of signaling pathway (GO:0023058)	2.78934838
86	regulation of synapse structural plasticity (GO:0051823)	2.78237127
87	negative regulation of lyase activity (GO:0051350)	2.77121628
88	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.77090865
89	response to sterol (GO:0036314)	2.76811279
90	postsynaptic membrane organization (GO:0001941)	2.76509356
91	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.75367056
92	sulfate transport (GO:0008272)	2.74651936
93	cytidine deamination (GO:0009972)	2.72422147
94	cytidine metabolic process (GO:0046087)	2.72422147
95	cytidine catabolic process (GO:0006216)	2.72422147
96	negative regulation by host of viral transcription (GO:0043922)	2.72350318
97	negative regulation of stem cell proliferation (GO:2000647)	2.66659864
98	positive regulation of T cell cytokine production (GO:0002726)	2.64793024
99	primary amino compound metabolic process (GO:1901160)	2.64549553
100	embryonic axis specification (GO:0000578)	2.64035658

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.38666687
2	VDR_22108803_ChIP-Seq_LS180_Human	3.86960759
3	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.75494778
4	AR_21572438_ChIP-Seq_LNCaP_Human	3.29991374
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.86948559
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.72793614
7	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.69540045
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.67827941
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.47146251
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.43942749
11	P300_19829295_ChIP-Seq_ESCs_Human	2.32432059
12	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.32056505
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.28495288
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.27507412
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.15876800
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13189379
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.12999218
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09932207
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.08940178
20	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.89831083
21	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.86871195
22	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.75404370
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.75334541
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69835029
25	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.67984569
26	NANOG_19829295_ChIP-Seq_ESCs_Human	1.65215976
27	SOX2_19829295_ChIP-Seq_ESCs_Human	1.65215976
28	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.64866299
29	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.60392441
30	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.58031337
31	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.56250848
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.56157807
33	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.54722287
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.53971893
35	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.53072196
36	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.48800586
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45410943
38	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.44938921
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.44763573
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44763573
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.44510474
42	TP53_16413492_ChIP-PET_HCT116_Human	1.44458698
43	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.43986694
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40614750
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40036895
46	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38362125
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37972406
48	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.36661995
49	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.36011480
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35876944
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35876944
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34036649
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34036649
54	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.33669870
55	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.33669870
56	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.31150129
57	EGR1_19032775_ChIP-ChIP_M12_Human	1.26813646
58	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.22368121
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22159182
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21587692
61	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20215851
62	AR_25329375_ChIP-Seq_VCAP_Human	1.19123939
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.19088117
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17507970
65	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17135952
66	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.16225353
67	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13568547
68	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.12437928
69	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.12432344
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.11730244
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.11512592
72	RXR_22108803_ChIP-Seq_LS180_Human	1.10676324
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.10201377
74	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.09270315
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09225591
76	FUS_26573619_Chip-Seq_HEK293_Human	1.08601695
77	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.07557906
78	SMAD4_21799915_ChIP-Seq_A2780_Human	1.06487955
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04187466
80	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.04156745
81	TP53_18474530_ChIP-ChIP_U2OS_Human	1.03332998
82	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.01815645
83	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.01390495
84	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.01369739
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01028143
86	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.00589133
87	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.00478835
88	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00228456
89	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.99082816
90	NCOR_22424771_ChIP-Seq_293T_Human	0.98125338
91	STAT3_23295773_ChIP-Seq_U87_Human	0.95412475
92	BCAT_22108803_ChIP-Seq_LS180_Human	0.94792240
93	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93829663
94	AR_20517297_ChIP-Seq_VCAP_Human	0.91135877
95	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.90891517
96	TAF15_26573619_Chip-Seq_HEK293_Human	0.90635189
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.89964861
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.89067432
99	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.86705582
100	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.86674173

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	6.03721761
2	MP0002837_dystrophic_cardiac_calcinosis	5.95373318
3	MP0002653_abnormal_ependyma_morphology	4.85717245
4	MP0000569_abnormal_digit_pigmentation	4.69831349
5	MP0003890_abnormal_embryonic-extraembry	2.83529525
6	MP0003646_muscle_fatigue	2.69077918
7	MP0002938_white_spotting	2.35871788
8	MP0005174_abnormal_tail_pigmentation	2.32783066
9	MP0003045_fibrosis	2.02240733
10	MP0003136_yellow_coat_color	11.3804490
11	MP0004147_increased_porphyrin_level	1.85394012
12	MP0003880_abnormal_central_pattern	1.83560672
13	MP0009384_cardiac_valve_regurgitation	1.68488746
14	MP0002928_abnormal_bile_duct	1.67891211
15	MP0010307_abnormal_tumor_latency	1.65339552
16	MP0005187_abnormal_penis_morphology	1.59802377
17	MP0002095_abnormal_skin_pigmentation	1.47841122
18	MP0003879_abnormal_hair_cell	1.45299097
19	MP0002822_catalepsy	1.43185003
20	MP0004134_abnormal_chest_morphology	1.40188133
21	MP0005410_abnormal_fertilization	1.37807445
22	MP0002735_abnormal_chemical_nociception	1.35138735
23	MP0004142_abnormal_muscle_tone	1.34677875
24	MP0005503_abnormal_tendon_morphology	1.33838351
25	MP0004145_abnormal_muscle_electrophysio	1.28312807
26	MP0002138_abnormal_hepatobiliary_system	1.24350383
27	MP0002277_abnormal_respiratory_mucosa	1.20344885
28	MP0003950_abnormal_plasma_membrane	1.20295770
29	MP0005670_abnormal_white_adipose	1.15422303
30	MP0005083_abnormal_biliary_tract	1.14115713
31	MP0002160_abnormal_reproductive_system	1.13508822
32	MP0005084_abnormal_gallbladder_morpholo	1.07371538
33	MP0005646_abnormal_pituitary_gland	1.07190753
34	MP0004043_abnormal_pH_regulation	1.06951446
35	MP0000647_abnormal_sebaceous_gland	1.02568438
36	MP0004381_abnormal_hair_follicle	1.01819967
37	MP0005085_abnormal_gallbladder_physiolo	0.99039134
38	MP0001970_abnormal_pain_threshold	0.96578228
39	MP0005330_cardiomyopathy	0.96072367
40	MP0002272_abnormal_nervous_system	0.95579621
41	MP0003195_calcinosis	0.86179513
42	MP0009745_abnormal_behavioral_response	0.84096632
43	MP0000778_abnormal_nervous_system	0.83322676
44	MP0005257_abnormal_intraocular_pressure	0.83008731
45	MP0009046_muscle_twitch	0.82192336
46	MP0002102_abnormal_ear_morphology	0.81738034
47	MP0000749_muscle_degeneration	0.81668473
48	MP0006276_abnormal_autonomic_nervous	0.80188341
49	MP0003011_delayed_dark_adaptation	0.80014347
50	MP0005075_abnormal_melanosome_morpholog	0.79858924
51	MP0001968_abnormal_touch/_nociception	0.77790067
52	MP0001529_abnormal_vocalization	0.76762973
53	MP0005389_reproductive_system_phenotype	0.76360966
54	MP0003137_abnormal_impulse_conducting	0.74681632
55	MP0002168_other_aberrant_phenotype	0.72600202
56	MP0002733_abnormal_thermal_nociception	0.72090605
57	MP0002075_abnormal_coat/hair_pigmentati	0.70998879
58	MP0001485_abnormal_pinna_reflex	0.70429936
59	MP0003718_maternal_effect	0.68815663
60	MP0002572_abnormal_emotion/affect_behav	0.68526724
61	MP0005395_other_phenotype	0.68376809
62	MP0000372_irregular_coat_pigmentation	0.67012091
63	MP0002067_abnormal_sensory_capabilities	0.66978116
64	MP0000955_abnormal_spinal_cord	0.65963396
65	MP0002064_seizures	0.63892937
66	MP0001929_abnormal_gametogenesis	0.63181271
67	MP0002736_abnormal_nociception_after	0.62840820
68	MP0003638_abnormal_response/metabolism_	0.62757439
69	MP0002876_abnormal_thyroid_physiology	0.62726182
70	MP0000026_abnormal_inner_ear	0.61504128
71	MP0003635_abnormal_synaptic_transmissio	0.61374425
72	MP0001501_abnormal_sleep_pattern	0.61222199
73	MP0005671_abnormal_response_to	0.60804139
74	MP0001299_abnormal_eye_distance/	0.59760036
75	MP0002269_muscular_atrophy	0.56941567
76	MP0003698_abnormal_male_reproductive	0.55280027
77	MP0001905_abnormal_dopamine_level	0.54962937
78	MP0001879_abnormal_lymphatic_vessel	0.54916595
79	MP0004742_abnormal_vestibular_system	0.54487076
80	MP0002282_abnormal_trachea_morphology	0.51879569
81	MP0002734_abnormal_mechanical_nocicepti	0.51666895
82	MP0002163_abnormal_gland_morphology	0.51542797
83	MP0000631_abnormal_neuroendocrine_gland	0.51193735
84	MP0001963_abnormal_hearing_physiology	0.50731311
85	MP0003252_abnormal_bile_duct	0.50626116
86	MP0000427_abnormal_hair_cycle	0.50617899
87	MP0003763_abnormal_thymus_physiology	0.48258415
88	MP0002132_abnormal_respiratory_system	0.48117076
89	MP0001186_pigmentation_phenotype	0.47961580
90	MP0006072_abnormal_retinal_apoptosis	0.47546055
91	MP0002063_abnormal_learning/memory/cond	0.47167736
92	MP0002210_abnormal_sex_determination	0.46821122
93	MP0005386_behavior/neurological_phenoty	0.46178313
94	MP0004924_abnormal_behavior	0.46178313
95	MP0000230_abnormal_systemic_arterial	0.44778849
96	MP0003633_abnormal_nervous_system	0.43712074
97	MP0005167_abnormal_blood-brain_barrier	0.43615506
98	MP0001984_abnormal_olfaction	0.43505155
99	MP0008770_decreased_survivor_rate	0.41873583
100	MP0001986_abnormal_taste_sensitivity	0.41457376

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	8.06100477
2	Large for gestational age (HP:0001520)	5.82335881
3	Atonic seizures (HP:0010819)	4.98957671
4	Neoplasm of the heart (HP:0100544)	4.80406653
5	Short 4th metacarpal (HP:0010044)	4.32649825
6	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	4.32649825
7	Hemiplegia (HP:0002301)	4.03763522
8	Amelogenesis imperfecta (HP:0000705)	4.01391213
9	Parakeratosis (HP:0001036)	3.90160424
10	Aplastic anemia (HP:0001915)	3.85281405
11	Supernumerary ribs (HP:0005815)	3.84773696
12	Cortical visual impairment (HP:0100704)	3.82852135
13	Dialeptic seizures (HP:0011146)	3.80569406
14	Supernumerary bones of the axial skeleton (HP:0009144)	3.78574154
15	Abnormality of the diencephalon (HP:0010662)	3.68684097
16	Broad face (HP:0000283)	3.53529257
17	Median cleft lip (HP:0000161)	3.53172203
18	Hyperkalemia (HP:0002153)	3.51722801
19	Abnormality of the nasal septum (HP:0000419)	3.49356059
20	Hemiparesis (HP:0001269)	3.47668080
21	Abnormality of the pons (HP:0007361)	3.47055308
22	Retinal dysplasia (HP:0007973)	3.30918500
23	Deformed sella turcica (HP:0002681)	3.24374117
24	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.24256227
25	Cerebellar dysplasia (HP:0007033)	3.22680711
26	Meningioma (HP:0002858)	3.21104330
27	Down-sloping shoulders (HP:0200021)	3.20635087
28	Bilateral microphthalmos (HP:0007633)	3.13261808
29	Abnormality of the 4th metacarpal (HP:0010012)	3.12318873
30	Depressed nasal tip (HP:0000437)	3.11074586
31	Gastrointestinal atresia (HP:0002589)	3.05558740
32	Abnormality of the sella turcica (HP:0002679)	3.05032743
33	Short phalanx of the thumb (HP:0009660)	3.03789287
34	Focal seizures (HP:0007359)	2.96765391
35	Abnormality of the parietal bone (HP:0002696)	2.92063178
36	Medulloblastoma (HP:0002885)	2.88970000
37	Febrile seizures (HP:0002373)	2.87163055
38	Abnormal number of incisors (HP:0011064)	2.84003527
39	Esophageal atresia (HP:0002032)	2.78811758
40	Glioma (HP:0009733)	2.78617765
41	Midline defect of the nose (HP:0004122)	2.78475651
42	Type II lissencephaly (HP:0007260)	2.74286359
43	Absence seizures (HP:0002121)	2.70335158
44	Hemivertebrae (HP:0002937)	2.57436141
45	Retinal atrophy (HP:0001105)	2.52944683
46	Bone cyst (HP:0012062)	2.51724539
47	Large earlobe (HP:0009748)	2.51003866
48	Spastic paraparesis (HP:0002313)	2.50097869
49	Acanthocytosis (HP:0001927)	2.47974366
50	Hypoplasia of the pons (HP:0012110)	2.44747297
51	Rib fusion (HP:0000902)	2.42448610
52	Albinism (HP:0001022)	2.41132967
53	Septo-optic dysplasia (HP:0100842)	2.38148849
54	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.37685535
55	3-Methylglutaconic aciduria (HP:0003535)	2.36922437
56	Milia (HP:0001056)	2.31020454
57	Neoplasm of striated muscle (HP:0009728)	2.29555685
58	Vertebral fusion (HP:0002948)	2.28121481
59	Neoplasm of the oral cavity (HP:0100649)	2.21703059
60	Absent septum pellucidum (HP:0001331)	2.21316014
61	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.19214418
62	Patchy hypopigmentation of hair (HP:0011365)	2.11607964
63	Basal cell carcinoma (HP:0002671)	2.11414725
64	Benign neoplasm of the central nervous system (HP:0100835)	2.09589721
65	Status epilepticus (HP:0002133)	2.08356338
66	Anterior segment dysgenesis (HP:0007700)	2.08198729
67	Optic nerve coloboma (HP:0000588)	2.04681723
68	Short tibia (HP:0005736)	2.04446834
69	Hypoplastic iliac wings (HP:0002866)	2.01910327
70	IgG deficiency (HP:0004315)	1.98297807
71	Hamartoma (HP:0010566)	1.94181002
72	Pancreatic cysts (HP:0001737)	1.93285293
73	Type 2 muscle fiber atrophy (HP:0003554)	1.91521288
74	Cutaneous melanoma (HP:0012056)	1.89741735
75	White forelock (HP:0002211)	1.89273243
76	Metaphyseal dysplasia (HP:0100255)	1.87988485
77	Abnormality of potassium homeostasis (HP:0011042)	1.84571267
78	Abnormality of midbrain morphology (HP:0002418)	1.82550447
79	Molar tooth sign on MRI (HP:0002419)	1.82550447
80	Non-midline cleft lip (HP:0100335)	1.80983499
81	Difficulty walking (HP:0002355)	1.80926938
82	Intestinal atresia (HP:0011100)	1.80629353
83	Pachygyria (HP:0001302)	1.80023103
84	Neuroendocrine neoplasm (HP:0100634)	1.79952378
85	Pancytopenia (HP:0001876)	1.79749404
86	Clumsiness (HP:0002312)	1.79551651
87	Postnatal microcephaly (HP:0005484)	1.77736025
88	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	1.77637157
89	Vertebral hypoplasia (HP:0008417)	1.77637157
90	Abnormality of the vocal cords (HP:0008777)	1.76359095
91	Colon cancer (HP:0003003)	1.76182626
92	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.75475089
93	Chronic diarrhea (HP:0002028)	1.74616449
94	Abnormality of the renal collecting system (HP:0004742)	1.74527640
95	Missing ribs (HP:0000921)	1.74495060
96	Congenital ichthyosiform erythroderma (HP:0007431)	1.73863646
97	Stomatitis (HP:0010280)	1.73517319
98	Intestinal polyp (HP:0005266)	1.72686236
99	IgM deficiency (HP:0002850)	1.71752947
100	Hyperglycinemia (HP:0002154)	1.71744237

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	6.50307297
2	TSSK6	4.45933164
3	CAMK1D	4.25324439
4	PNCK	4.06617928
5	MAPK15	4.04916261
6	CAMKK2	3.95679636
7	STK38L	3.73484165
8	LATS2	3.23399407
9	CAMK1G	2.94026475
10	EPHA4	2.84688799
11	ZAK	2.63584608
12	MAP2K2	2.39812479
13	EPHA3	2.21888484
14	FRK	1.92264624
15	CAMKK1	1.65133388
16	WEE1	1.59833861
17	TXK	1.53092439
18	PRKD3	1.47526584
19	WNK4	1.44784979
20	VRK1	1.44242932
21	MUSK	1.43655154
22	FER	1.29680983
23	EPHB1	1.28040139
24	BCKDK	1.21063971
25	TLK1	1.20858408
26	PIK3CA	1.20591201
27	MAP3K7	1.17988378
28	ADRBK2	1.13485616
29	MAP3K12	1.12776567
30	TAOK3	1.03674965
31	EPHB2	1.02409632
32	NEK2	1.02177373
33	TIE1	1.00233151
34	NLK	0.99297791
35	STK38	0.90022334
36	STK3	0.89822872
37	LIMK1	0.77996567
38	CDK3	0.77827721
39	NME1	0.74193699
40	ACVR1B	0.72635197
41	CAMK4	0.71718940
42	ITK	0.71060890
43	PHKG1	0.70687654
44	PHKG2	0.70687654
45	DYRK2	0.70449922
46	BMPR1B	0.68064960
47	MAPKAPK5	0.67815563
48	IKBKB	0.67469856
49	GRK7	0.65115025
50	CAMK1	0.64630208
51	PKN2	0.63472045
52	NUAK1	0.60679620
53	MAP4K2	0.59973198
54	CSNK1A1L	0.55940010
55	PTK2B	0.54575893
56	PRKD1	0.54552844
57	TESK2	0.53823742
58	PIK3CG	0.52384168
59	WNK1	0.50623748
60	NEK1	0.49648753
61	WNK3	0.49216077
62	PINK1	0.47217145
63	TYRO3	0.44511791
64	TESK1	0.44246138
65	MST4	0.40286379
66	PRKAA2	0.40112892
67	MELK	0.38780824
68	FES	0.37672097
69	OBSCN	0.37273428
70	DAPK2	0.35547893
71	TNIK	0.32619798
72	FLT3	0.31930216
73	ERBB2	0.31380561
74	MAP3K11	0.30955779
75	TEC	0.30600226
76	PLK3	0.28838710
77	MAP4K1	0.26569061
78	GRK1	0.26529397
79	OXSR1	0.25553612
80	MAPK7	0.24035013
81	KDR	0.23769467
82	PRKACA	0.23313013
83	ADRBK1	0.23265742
84	PRKCG	0.20016812
85	AKT2	0.19228584
86	CHUK	0.18738341
87	CHEK2	0.18705787
88	ABL1	0.17432398
89	MAP3K2	0.17191596
90	GRK5	0.16040571
91	HIPK2	0.15795353
92	AURKA	0.15468795
93	IKBKE	0.15033767
94	INSRR	0.14386516
95	NTRK2	0.13532127
96	RPS6KA5	0.13500663
97	MAPK3	0.13417215
98	PIM1	0.12458570
99	NTRK3	0.11078776
100	MET	0.10506093

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	6.76317554
2	Phototransduction_Homo sapiens_hsa04744	3.59972326
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.03952582
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.91170073
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.81158366
6	Sphingolipid metabolism_Homo sapiens_hsa00600	2.31615560
7	Antigen processing and presentation_Homo sapiens_hsa04612	2.18538435
8	Nicotine addiction_Homo sapiens_hsa05033	2.12555908
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.06100535
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.02793913
11	Primary immunodeficiency_Homo sapiens_hsa05340	1.75600397
12	Morphine addiction_Homo sapiens_hsa05032	1.58636590
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.48281612
14	Taste transduction_Homo sapiens_hsa04742	1.41725385
15	Calcium signaling pathway_Homo sapiens_hsa04020	1.39632347
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.34570749
17	Estrogen signaling pathway_Homo sapiens_hsa04915	1.32253753
18	cAMP signaling pathway_Homo sapiens_hsa04024	1.30252192
19	Sulfur metabolism_Homo sapiens_hsa00920	1.24821872
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.23402132
21	GABAergic synapse_Homo sapiens_hsa04727	1.17285728
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16334370
23	Insulin secretion_Homo sapiens_hsa04911	1.10090409
24	Sulfur relay system_Homo sapiens_hsa04122	1.08277445
25	Butanoate metabolism_Homo sapiens_hsa00650	1.05995968
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.02932491
27	Phenylalanine metabolism_Homo sapiens_hsa00360	1.01660687
28	Steroid biosynthesis_Homo sapiens_hsa00100	0.99984630
29	Basal cell carcinoma_Homo sapiens_hsa05217	0.99537393
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.98424491
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97600273
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96903367
33	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96094904
34	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.94409464
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.90018783
36	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88725064
37	Graft-versus-host disease_Homo sapiens_hsa05332	0.86021323
38	Salivary secretion_Homo sapiens_hsa04970	0.84108416
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83227002
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82842711
41	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82836651
42	Notch signaling pathway_Homo sapiens_hsa04330	0.80378646
43	One carbon pool by folate_Homo sapiens_hsa00670	0.79129677
44	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.76825588
45	Legionellosis_Homo sapiens_hsa05134	0.74952172
46	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.74821558
47	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.74116434
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.74099102
49	Olfactory transduction_Homo sapiens_hsa04740	0.73525975
50	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.71747989
51	Axon guidance_Homo sapiens_hsa04360	0.71260248
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71088790
53	Prion diseases_Homo sapiens_hsa05020	0.71076972
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.70044305
55	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.68158403
56	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.68086102
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67581156
58	Asthma_Homo sapiens_hsa05310	0.67279677
59	Proteasome_Homo sapiens_hsa03050	0.67118517
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.67092883
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67052506
62	Linoleic acid metabolism_Homo sapiens_hsa00591	0.65354679
63	Oxidative phosphorylation_Homo sapiens_hsa00190	0.65199305
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64746196
65	PPAR signaling pathway_Homo sapiens_hsa03320	0.63852884
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63368349
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.63324160
68	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.62897248
69	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.62629573
70	Viral myocarditis_Homo sapiens_hsa05416	0.61800682
71	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61478906
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.59725839
73	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.58018907
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57385884
75	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.56474913
76	Retinol metabolism_Homo sapiens_hsa00830	0.56043435
77	Parkinsons disease_Homo sapiens_hsa05012	0.54874703
78	Basal transcription factors_Homo sapiens_hsa03022	0.52108866
79	Regulation of autophagy_Homo sapiens_hsa04140	0.50019362
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49716106
81	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.48044907
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46825660
83	Cardiac muscle contraction_Homo sapiens_hsa04260	0.46461379
84	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.46418819
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.44832584
86	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.44146108
87	Homologous recombination_Homo sapiens_hsa03440	0.43310787
88	Allograft rejection_Homo sapiens_hsa05330	0.40416269
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.40240144
90	Melanogenesis_Homo sapiens_hsa04916	0.39690678
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38843524
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.37323125
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36730849
94	Serotonergic synapse_Homo sapiens_hsa04726	0.35536291
95	Circadian entrainment_Homo sapiens_hsa04713	0.35460707
96	Bile secretion_Homo sapiens_hsa04976	0.34883763
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.34724068
98	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34487487
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.34059910
100	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.30835115

VTI1BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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