VTI1BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)7.29228780
2ribosomal small subunit assembly (GO:0000028)6.54499428
3viral transcription (GO:0019083)6.47002905
4translational termination (GO:0006415)6.34296840
5ribosomal small subunit biogenesis (GO:0042274)5.71770960
6autophagic vacuole fusion (GO:0000046)5.63736423
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.56192581
8ATP synthesis coupled proton transport (GO:0015986)5.56192581
9nonmotile primary cilium assembly (GO:0035058)5.53881074
10rRNA modification (GO:0000154)5.35531555
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.32977052
12behavioral response to nicotine (GO:0035095)5.27744800
13rRNA methylation (GO:0031167)5.19028516
14translational elongation (GO:0006414)5.18477986
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.17080443
16cotranslational protein targeting to membrane (GO:0006613)5.03904409
17protein targeting to ER (GO:0045047)5.02494091
18cellular protein complex disassembly (GO:0043624)4.81121626
19viral life cycle (GO:0019058)4.80982410
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.80844822
21protein localization to endoplasmic reticulum (GO:0070972)4.78221058
22GDP-mannose metabolic process (GO:0019673)4.76670971
23purine deoxyribonucleotide catabolic process (GO:0009155)4.73061352
24chaperone-mediated protein transport (GO:0072321)4.63843982
25peptidyl-arginine omega-N-methylation (GO:0035247)4.62511021
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.61700142
27substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.59118417
28substrate-independent telencephalic tangential migration (GO:0021826)4.59118417
29translational initiation (GO:0006413)4.31912513
30peptidyl-arginine methylation (GO:0018216)4.27491446
31peptidyl-arginine N-methylation (GO:0035246)4.27491446
32protein complex disassembly (GO:0043241)4.08742799
33organelle membrane fusion (GO:0090174)4.02915656
34macromolecular complex disassembly (GO:0032984)4.02021055
35sequestering of actin monomers (GO:0042989)4.01338177
36ribosomal large subunit biogenesis (GO:0042273)3.86307081
37dendritic spine morphogenesis (GO:0060997)3.71917084
38protein kinase C signaling (GO:0070528)3.71679750
39somite development (GO:0061053)3.69545812
40histone arginine methylation (GO:0034969)3.69410313
41regulation of cilium movement (GO:0003352)3.67939033
42regulation of telomerase activity (GO:0051972)3.62242394
43protein neddylation (GO:0045116)3.62128799
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.61629361
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.61629361
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58266328
47positive regulation of T cell apoptotic process (GO:0070234)3.57387373
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.57198868
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.56997510
50respiratory electron transport chain (GO:0022904)3.55742805
51ubiquinone biosynthetic process (GO:0006744)3.55456532
52electron transport chain (GO:0022900)3.54727893
53ventricular system development (GO:0021591)3.48014821
54preassembly of GPI anchor in ER membrane (GO:0016254)3.47953204
55regulation of microtubule-based movement (GO:0060632)3.45254591
56protein targeting to membrane (GO:0006612)3.44503506
57translation (GO:0006412)3.41624845
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.40194491
59auditory behavior (GO:0031223)3.36111072
60organelle disassembly (GO:1903008)3.34686970
61iron-sulfur cluster assembly (GO:0016226)3.33807902
62metallo-sulfur cluster assembly (GO:0031163)3.33807902
63hematopoietic stem cell differentiation (GO:0060218)3.33539079
64positive regulation of defense response to virus by host (GO:0002230)3.29477115
65ATP biosynthetic process (GO:0006754)3.28914455
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.25226166
67DNA deamination (GO:0045006)3.24759841
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24695203
69ribonucleoprotein complex biogenesis (GO:0022613)3.22046943
70mRNA catabolic process (GO:0006402)3.18664667
71ribonucleoprotein complex disassembly (GO:0032988)3.13966207
72GTP biosynthetic process (GO:0006183)3.13546585
73purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10531869
74left/right axis specification (GO:0070986)3.10440765
75positive regulation of respiratory burst (GO:0060267)3.09647807
76water-soluble vitamin biosynthetic process (GO:0042364)3.06392056
77inner mitochondrial membrane organization (GO:0007007)3.05142660
78negative regulation of telomerase activity (GO:0051974)3.04174757
79mannose metabolic process (GO:0006013)2.99977703
80ubiquinone metabolic process (GO:0006743)2.98905142
81C-terminal protein lipidation (GO:0006501)2.94475261
82synaptic transmission, cholinergic (GO:0007271)2.93905743
83ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89770753
84deoxyribonucleotide catabolic process (GO:0009264)2.86008502
85cellular component biogenesis (GO:0044085)2.85968613
86positive regulation of heat generation (GO:0031652)2.85105071
87G-protein coupled receptor internalization (GO:0002031)2.80518677
88RNA catabolic process (GO:0006401)2.76526701
89rRNA processing (GO:0006364)2.76090933
90quinone biosynthetic process (GO:1901663)2.75529734
91NADH dehydrogenase complex assembly (GO:0010257)2.75051121
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75051121
93mitochondrial respiratory chain complex I assembly (GO:0032981)2.75051121
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74491026
95regulation of mitotic spindle checkpoint (GO:1903504)2.74491026
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.74184579
97termination of RNA polymerase III transcription (GO:0006386)2.74184579
98positive regulation of lymphocyte apoptotic process (GO:0070230)2.73865238
99hydrogen ion transmembrane transport (GO:1902600)2.73419867
100DNA damage response, detection of DNA damage (GO:0042769)2.73168112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.45493821
2EZH2_22144423_ChIP-Seq_EOC_Human4.87449610
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.85886624
4ETS1_20019798_ChIP-Seq_JURKAT_Human3.39025572
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.29083069
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.23160915
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22232725
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20667537
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98593400
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.87772107
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86856838
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59999169
13CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.29571631
14ZNF274_21170338_ChIP-Seq_K562_Hela2.24931735
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.20658384
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.20355907
17IGF1R_20145208_ChIP-Seq_DFB_Human2.08409970
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07983451
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07461957
20TTF2_22483619_ChIP-Seq_HELA_Human2.02739908
21XRN2_22483619_ChIP-Seq_HELA_Human2.01487430
22VDR_23849224_ChIP-Seq_CD4+_Human1.97627694
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95106327
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85658856
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84946270
26ELK1_19687146_ChIP-ChIP_HELA_Human1.79894648
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79604604
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.75847872
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74601719
30ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73501404
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65856989
32FOXP3_21729870_ChIP-Seq_TREG_Human1.64092955
33TP53_22573176_ChIP-Seq_HFKS_Human1.60048837
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58100000
35CIITA_25753668_ChIP-Seq_RAJI_Human1.57216872
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55844541
37GABP_19822575_ChIP-Seq_HepG2_Human1.54234935
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53950793
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51836056
40CTCF_18555785_ChIP-Seq_MESCs_Mouse1.45804940
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43309732
42MYC_18940864_ChIP-ChIP_HL60_Human1.41008523
43PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40609190
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32576114
45ERA_21632823_ChIP-Seq_H3396_Human1.28745673
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24940725
47DCP1A_22483619_ChIP-Seq_HELA_Human1.23650095
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23327137
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20898770
50NCOR_22424771_ChIP-Seq_293T_Human1.20564712
51TP53_22127205_ChIP-Seq_IMR90_Human1.20479339
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20380074
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.17820297
54FOXP1_21924763_ChIP-Seq_HESCs_Human1.17047570
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16526238
56BCL6_27268052_Chip-Seq_Bcells_Human1.16109458
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.15038701
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14792302
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14080084
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13921438
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13790893
62ERG_20517297_ChIP-Seq_VCAP_Human1.09730672
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08404704
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06575185
65TAF2_19829295_ChIP-Seq_ESCs_Human1.04065737
66RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03637758
67CTCF_20526341_ChIP-Seq_ESCs_Human1.03186228
68P68_20966046_ChIP-Seq_HELA_Human1.03022944
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02785678
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02417482
71GATA3_21867929_ChIP-Seq_TH1_Mouse1.02073760
72EWS_26573619_Chip-Seq_HEK293_Human1.01748286
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00814523
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00321490
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.00010891
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99675456
77E2F1_20622854_ChIP-Seq_HELA_Human0.99346426
78IRF1_19129219_ChIP-ChIP_H3396_Human0.99076871
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97853726
80SA1_27219007_Chip-Seq_Bcells_Human0.97557304
81TP63_19390658_ChIP-ChIP_HaCaT_Human0.95880059
82ELF5_23300383_ChIP-Seq_T47D_Human0.95163909
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94736994
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93531211
85SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91948164
86NANOG_20526341_ChIP-Seq_ESCs_Human0.91915340
87BCOR_27268052_Chip-Seq_Bcells_Human0.90514352
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89692867
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89075398
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88806491
91KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88538854
92MYC_19829295_ChIP-Seq_ESCs_Human0.88273953
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87396695
94RARB_24833708_ChIP-Seq_LIVER_Mouse0.85776099
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.85582658
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85228345
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83594341
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.83224358
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82700401
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82318719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.20472364
2MP0005083_abnormal_biliary_tract6.29774740
3MP0005084_abnormal_gallbladder_morpholo3.18298108
4MP0005167_abnormal_blood-brain_barrier2.66531323
5MP0001529_abnormal_vocalization2.61149881
6MP0001905_abnormal_dopamine_level2.47527381
7MP0005174_abnormal_tail_pigmentation2.28259452
8MP0003718_maternal_effect2.21095614
9MP0001986_abnormal_taste_sensitivity2.20793807
10MP0010386_abnormal_urinary_bladder2.19011333
11MP0003186_abnormal_redox_activity2.18215913
12MP0002138_abnormal_hepatobiliary_system2.00309502
13MP0003136_yellow_coat_color1.97217700
14MP0010030_abnormal_orbit_morphology1.89517075
15MP0006292_abnormal_olfactory_placode1.84216309
16MP0008789_abnormal_olfactory_epithelium1.74013044
17MP0002139_abnormal_hepatobiliary_system1.69341991
18MP0005058_abnormal_lysosome_morphology1.64690602
19MP0005499_abnormal_olfactory_system1.61704290
20MP0005394_taste/olfaction_phenotype1.61704290
21MP0001293_anophthalmia1.59106266
22MP0005423_abnormal_somatic_nervous1.54522419
23MP0001968_abnormal_touch/_nociception1.51174017
24MP0001970_abnormal_pain_threshold1.48442361
25MP0006276_abnormal_autonomic_nervous1.48107870
26MP0002736_abnormal_nociception_after1.44785993
27MP0004142_abnormal_muscle_tone1.39199498
28MP0002102_abnormal_ear_morphology1.38825944
29MP0004133_heterotaxia1.37500383
30MP0005645_abnormal_hypothalamus_physiol1.36211156
31MP0010368_abnormal_lymphatic_system1.30686732
32MP0006035_abnormal_mitochondrial_morpho1.30562666
33MP0004859_abnormal_synaptic_plasticity1.28757299
34MP0003172_abnormal_lysosome_physiology1.28621274
35MP0001919_abnormal_reproductive_system1.28026086
36MP0002735_abnormal_chemical_nociception1.26580921
37MP0000538_abnormal_urinary_bladder1.25361097
38MP0006082_CNS_inflammation1.23237496
39MP0004019_abnormal_vitamin_homeostasis1.22002016
40MP0003567_abnormal_fetal_cardiomyocyte1.20488633
41MP0002234_abnormal_pharynx_morphology1.16514275
42MP0004742_abnormal_vestibular_system1.16276718
43MP0005389_reproductive_system_phenotype1.15019218
44MP0003011_delayed_dark_adaptation1.14885504
45MP0002909_abnormal_adrenal_gland1.12918816
46MP0005551_abnormal_eye_electrophysiolog1.10921845
47MP0002733_abnormal_thermal_nociception1.09747069
48MP0009840_abnormal_foam_cell1.09078746
49MP0002653_abnormal_ependyma_morphology1.08783797
50MP0003638_abnormal_response/metabolism_1.07557237
51MP0002734_abnormal_mechanical_nocicepti1.06957922
52MP0002638_abnormal_pupillary_reflex1.06941504
53MP0006036_abnormal_mitochondrial_physio1.06927452
54MP0003315_abnormal_perineum_morphology1.05426977
55MP0005253_abnormal_eye_physiology1.00410319
56MP0008875_abnormal_xenobiotic_pharmacok1.00410307
57MP0002572_abnormal_emotion/affect_behav0.99380654
58MP0002095_abnormal_skin_pigmentation0.98780662
59MP0001502_abnormal_circadian_rhythm0.98664071
60MP0005636_abnormal_mineral_homeostasis0.97344776
61MP0002837_dystrophic_cardiac_calcinosis0.96445213
62MP0009764_decreased_sensitivity_to0.95722948
63MP0001324_abnormal_eye_pigmentation0.94352022
64MP0005195_abnormal_posterior_eye0.90862853
65MP0008872_abnormal_physiological_respon0.89991148
66MP0002160_abnormal_reproductive_system0.89523669
67MP0003880_abnormal_central_pattern0.88224936
68MP0002332_abnormal_exercise_endurance0.87164720
69MP0002063_abnormal_learning/memory/cond0.86757041
70MP0008058_abnormal_DNA_repair0.83744362
71MP0000778_abnormal_nervous_system0.83150992
72MP0005448_abnormal_energy_balance0.82200758
73MP0003137_abnormal_impulse_conducting0.79782019
74MP0001764_abnormal_homeostasis0.79520325
75MP0002928_abnormal_bile_duct0.79209157
76MP0000015_abnormal_ear_pigmentation0.78554828
77MP0000343_altered_response_to0.76609121
78MP0003635_abnormal_synaptic_transmissio0.75557706
79MP0008775_abnormal_heart_ventricle0.74131823
80MP0001663_abnormal_digestive_system0.72054481
81MP0002938_white_spotting0.71145719
82MP0002067_abnormal_sensory_capabilities0.70932669
83MP0003724_increased_susceptibility_to0.70772198
84MP0003646_muscle_fatigue0.70081357
85MP0002272_abnormal_nervous_system0.68346678
86MP0003075_altered_response_to0.67143499
87MP0002177_abnormal_outer_ear0.65937729
88MP0000049_abnormal_middle_ear0.64811405
89MP0004215_abnormal_myocardial_fiber0.64379479
90MP0001756_abnormal_urination0.64188703
91MP0004885_abnormal_endolymph0.63913561
92MP0003329_amyloid_beta_deposits0.63619817
93MP0001501_abnormal_sleep_pattern0.61596639
94MP0000026_abnormal_inner_ear0.59985952
95MP0005391_vision/eye_phenotype0.59330248
96MP0003878_abnormal_ear_physiology0.58587163
97MP0005377_hearing/vestibular/ear_phenot0.58587163
98MP0002064_seizures0.57597384
99MP0004145_abnormal_muscle_electrophysio0.57385128
100MP0008995_early_reproductive_senescence0.56806065

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)6.64200449
2Abnormality of midbrain morphology (HP:0002418)6.64200449
3Partial duplication of thumb phalanx (HP:0009944)5.74339213
4Partial duplication of the phalanx of hand (HP:0009999)4.98161820
5Reticulocytopenia (HP:0001896)4.85193338
6Thrombocytosis (HP:0001894)4.27473249
7Abnormal number of erythroid precursors (HP:0012131)4.01206427
8Abnormality of cells of the erythroid lineage (HP:0012130)3.87670218
9Reduced antithrombin III activity (HP:0001976)3.64219363
10Increased hepatocellular lipid droplets (HP:0006565)3.63773297
11Type I transferrin isoform profile (HP:0003642)3.57875224
12Rectal fistula (HP:0100590)3.51359687
13Rectovaginal fistula (HP:0000143)3.51359687
14Aplasia/Hypoplasia of the sacrum (HP:0008517)3.39567892
15Lipid accumulation in hepatocytes (HP:0006561)3.33283685
16Prolonged partial thromboplastin time (HP:0003645)3.25318339
17Proximal tubulopathy (HP:0000114)3.22299094
18Duplication of thumb phalanx (HP:0009942)3.09719211
19Acute necrotizing encephalopathy (HP:0006965)3.08405052
20Intrahepatic cholestasis (HP:0001406)3.06999362
21Macrocytic anemia (HP:0001972)3.05944458
22Hypoplasia of the pons (HP:0012110)3.05249486
23Vaginal fistula (HP:0004320)3.04488095
24Abnormality of the pons (HP:0007361)2.97299852
25Intestinal fistula (HP:0100819)2.88800395
26Renal Fanconi syndrome (HP:0001994)2.83680348
27Mitochondrial inheritance (HP:0001427)2.81936808
28Anencephaly (HP:0002323)2.79392549
29Abnormality of the intrinsic pathway (HP:0010989)2.77645612
30Acute encephalopathy (HP:0006846)2.75893164
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.72724485
32Abnormal protein N-linked glycosylation (HP:0012347)2.72724485
33Abnormal protein glycosylation (HP:0012346)2.72724485
34Abnormal glycosylation (HP:0012345)2.72724485
35Severe visual impairment (HP:0001141)2.63819860
363-Methylglutaconic aciduria (HP:0003535)2.63007445
37Colon cancer (HP:0003003)2.61039808
38Increased CSF lactate (HP:0002490)2.57585113
39Bifid tongue (HP:0010297)2.55666940
40Epileptic encephalopathy (HP:0200134)2.53909585
41Vacuolated lymphocytes (HP:0001922)2.53276399
42Abnormality of the phalanges of the hallux (HP:0010057)2.51076502
43Abnormal mitochondria in muscle tissue (HP:0008316)2.48424938
44Mesangial abnormality (HP:0001966)2.45520760
45Hyperinsulinemic hypoglycemia (HP:0000825)2.43017435
46Testicular atrophy (HP:0000029)2.42514258
47Attenuation of retinal blood vessels (HP:0007843)2.40898573
48Progressive macrocephaly (HP:0004481)2.38945484
49Microretrognathia (HP:0000308)2.38626503
50Rib fusion (HP:0000902)2.37861037
51Squamous cell carcinoma (HP:0002860)2.37713453
52Bony spicule pigmentary retinopathy (HP:0007737)2.37033464
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.36391659
54Nephronophthisis (HP:0000090)2.35775168
55Absent thumb (HP:0009777)2.34173860
56Increased intramyocellular lipid droplets (HP:0012240)2.34100299
57Pancreatic cysts (HP:0001737)2.33460606
58Abnormal rod and cone electroretinograms (HP:0008323)2.31838695
59Abolished electroretinogram (ERG) (HP:0000550)2.26864940
60Pancreatic fibrosis (HP:0100732)2.26201078
6111 pairs of ribs (HP:0000878)2.22416286
62Fused cervical vertebrae (HP:0002949)2.20696569
63Hepatic necrosis (HP:0002605)2.20637278
64Pendular nystagmus (HP:0012043)2.20125840
65Hepatocellular necrosis (HP:0001404)2.18387877
66Cerebral edema (HP:0002181)2.17235124
67Multiple enchondromatosis (HP:0005701)2.12677067
68Increased serum lactate (HP:0002151)2.10999314
69Abnormality of reticulocytes (HP:0004312)2.10888661
70Oculomotor apraxia (HP:0000657)2.10617608
71Confusion (HP:0001289)2.07471258
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05664093
73Chronic hepatic failure (HP:0100626)2.04503428
74Missing ribs (HP:0000921)2.04291545
75Exertional dyspnea (HP:0002875)2.03718663
76Abnormal biliary tract physiology (HP:0012439)1.97492021
77Bile duct proliferation (HP:0001408)1.97492021
78True hermaphroditism (HP:0010459)1.96546685
79Retinal dysplasia (HP:0007973)1.96299218
80Congenital stationary night blindness (HP:0007642)1.91665809
81Pallor (HP:0000980)1.90909432
82Increased muscle lipid content (HP:0009058)1.89671004
83Abnormality of homocysteine metabolism (HP:0010919)1.89541850
84Homocystinuria (HP:0002156)1.89541850
85Abnormality of the renal medulla (HP:0100957)1.87197303
86Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85939064
87Triphalangeal thumb (HP:0001199)1.84106127
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82963379
89Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81819535
90Vertebral hypoplasia (HP:0008417)1.81819535
91Lactic acidosis (HP:0003128)1.78944295
92Abnormality of renal resorption (HP:0011038)1.76105328
93Generalized aminoaciduria (HP:0002909)1.74966694
94Abnormality of polysaccharide metabolism (HP:0011012)1.74337380
95Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74337380
96Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74337380
97Optic disc pallor (HP:0000543)1.74135608
98Hypoalbuminemia (HP:0003073)1.71003376
99Abnormal albumin level (HP:0012116)1.71003376
100Congenital, generalized hypertrichosis (HP:0004540)1.68394306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.70166241
2EPHB24.77228692
3NME22.87021055
4BCKDK2.55162551
5GRK12.40198250
6MAP2K72.31891034
7CASK2.17491312
8VRK22.08460639
9KSR12.03179325
10TEC1.92324749
11PIM21.70077790
12TESK21.68606659
13TLK11.65366538
14STK161.64737676
15NEK11.64139499
16TGFBR21.60877199
17LIMK11.59896106
18MAP2K61.28986310
19GRK71.21385294
20WNK41.21178389
21TBK11.15756373
22NUAK11.14240464
23DAPK21.13872235
24MAPK151.13334046
25MARK21.11893685
26CCNB11.10718407
27ADRBK21.09908208
28SRPK11.05542084
29MAP3K111.00595468
30TGFBR10.99613779
31PINK10.98574168
32AURKA0.97532489
33CHEK20.96457369
34ARAF0.95455004
35BMPR1B0.94098608
36ALK0.93902163
37PASK0.93539257
38DAPK30.84985563
39PHKG20.84977680
40PHKG10.84977680
41MST40.83617937
42CAMK10.81043927
43MARK10.78226752
44TESK10.76516279
45CAMKK20.75092670
46ZAK0.70980029
47CSNK1G30.69691547
48PKN10.67792580
49WNK30.67511803
50CSNK1G10.66973896
51DYRK20.64204772
52EPHA40.62196015
53CSNK1A1L0.58029811
54DYRK1B0.57571635
55IKBKE0.56646575
56PRKCI0.55687229
57WNK10.55308402
58CSNK1G20.55303236
59PRKCG0.54494729
60CAMKK10.53113414
61CDC70.52715512
62TSSK60.47254304
63RPS6KA20.45629256
64MARK30.44269463
65PRKACA0.42431061
66CSNK2A20.42130301
67RPS6KA50.42004824
68ACVR1B0.41497337
69NTRK20.40891351
70CDK80.39948604
71RPS6KA60.39706340
72PLK10.39422278
73ADRBK10.38643389
74CSNK2A10.36646058
75VRK10.35776671
76INSRR0.35458125
77AURKB0.34392419
78MAPKAPK50.33545761
79CAMK2A0.33538022
80MAPK70.31714181
81RPS6KL10.30770662
82RPS6KC10.30770662
83MATK0.30638879
84TAOK10.29705795
85ERBB20.29408976
86CSNK1A10.28533412
87CSK0.27708930
88CAMK2G0.27305748
89TAOK20.26275732
90MAP4K20.25950563
91ABL20.25430687
92EIF2AK20.25076896
93NEK20.24146111
94PRKCA0.23047467
95TAOK30.21873126
96PRKCZ0.21664929
97IKBKB0.21356759
98RPS6KB10.20876940
99PRKACB0.19880553
100KIT0.18745135

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.79514193
2Oxidative phosphorylation_Homo sapiens_hsa001904.38647013
3Parkinsons disease_Homo sapiens_hsa050123.59184277
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.32988497
5Sulfur relay system_Homo sapiens_hsa041223.08669022
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.96143968
7Huntingtons disease_Homo sapiens_hsa050162.84605083
8Alzheimers disease_Homo sapiens_hsa050102.71693058
9Cardiac muscle contraction_Homo sapiens_hsa042602.35053297
10Proteasome_Homo sapiens_hsa030502.34146419
11RNA polymerase_Homo sapiens_hsa030202.28481676
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10152011
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.85644555
14Fructose and mannose metabolism_Homo sapiens_hsa000511.78175405
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.75062057
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.69373546
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68535117
18Nicotine addiction_Homo sapiens_hsa050331.49645846
19Pyruvate metabolism_Homo sapiens_hsa006201.44484221
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34773712
21Lysosome_Homo sapiens_hsa041421.32247479
22Base excision repair_Homo sapiens_hsa034101.31170226
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25495126
24Fanconi anemia pathway_Homo sapiens_hsa034601.19935921
25Tryptophan metabolism_Homo sapiens_hsa003801.18375568
26RNA degradation_Homo sapiens_hsa030181.18275979
27Homologous recombination_Homo sapiens_hsa034401.18092557
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16361425
29beta-Alanine metabolism_Homo sapiens_hsa004101.15285708
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15192651
31Collecting duct acid secretion_Homo sapiens_hsa049661.07831237
32Propanoate metabolism_Homo sapiens_hsa006401.07157722
33Pyrimidine metabolism_Homo sapiens_hsa002401.06361787
34One carbon pool by folate_Homo sapiens_hsa006701.05722814
35Rheumatoid arthritis_Homo sapiens_hsa053230.99643112
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98264692
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96783335
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96661189
39Galactose metabolism_Homo sapiens_hsa000520.96008798
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92505002
41Peroxisome_Homo sapiens_hsa041460.88601777
42Linoleic acid metabolism_Homo sapiens_hsa005910.88262170
43Folate biosynthesis_Homo sapiens_hsa007900.86583067
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85101930
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84090199
46Taste transduction_Homo sapiens_hsa047420.82389986
47Mineral absorption_Homo sapiens_hsa049780.81976247
48Metabolic pathways_Homo sapiens_hsa011000.81726548
49Other glycan degradation_Homo sapiens_hsa005110.81715436
50Fatty acid elongation_Homo sapiens_hsa000620.80289835
51Nitrogen metabolism_Homo sapiens_hsa009100.78482852
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75807681
53Olfactory transduction_Homo sapiens_hsa047400.75704356
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75297771
55Basal transcription factors_Homo sapiens_hsa030220.74156157
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72872713
57Hedgehog signaling pathway_Homo sapiens_hsa043400.69672322
58Spliceosome_Homo sapiens_hsa030400.68896969
59Nucleotide excision repair_Homo sapiens_hsa034200.67535407
60Purine metabolism_Homo sapiens_hsa002300.65218137
61Mismatch repair_Homo sapiens_hsa034300.62542694
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57659302
63Glutathione metabolism_Homo sapiens_hsa004800.57369746
64Synaptic vesicle cycle_Homo sapiens_hsa047210.56628934
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56074679
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55902531
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54354050
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53649083
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53537498
70Histidine metabolism_Homo sapiens_hsa003400.52731808
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.52693107
72Chemical carcinogenesis_Homo sapiens_hsa052040.51455629
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50760847
74Protein export_Homo sapiens_hsa030600.50209202
75Carbon metabolism_Homo sapiens_hsa012000.47827839
76Phototransduction_Homo sapiens_hsa047440.44792232
77Steroid biosynthesis_Homo sapiens_hsa001000.44475975
78Butanoate metabolism_Homo sapiens_hsa006500.43514944
79Retinol metabolism_Homo sapiens_hsa008300.41750724
80Insulin secretion_Homo sapiens_hsa049110.41734086
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41503346
82Biosynthesis of amino acids_Homo sapiens_hsa012300.40475731
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40285696
84Morphine addiction_Homo sapiens_hsa050320.39301163
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38594238
86Asthma_Homo sapiens_hsa053100.37825946
87Serotonergic synapse_Homo sapiens_hsa047260.34002569
88Arginine and proline metabolism_Homo sapiens_hsa003300.33481267
89Ether lipid metabolism_Homo sapiens_hsa005650.30460231
90Fat digestion and absorption_Homo sapiens_hsa049750.29982819
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29218708
92Basal cell carcinoma_Homo sapiens_hsa052170.28434192
93Tyrosine metabolism_Homo sapiens_hsa003500.27698632
94Ovarian steroidogenesis_Homo sapiens_hsa049130.26717888
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21589521
96Pertussis_Homo sapiens_hsa051330.21380320
97Amphetamine addiction_Homo sapiens_hsa050310.20273585
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18442085
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.18344419
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.18174233

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