VTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54653611
2L-phenylalanine catabolic process (GO:0006559)7.54653611
3exogenous drug catabolic process (GO:0042738)7.23860731
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.19880274
5L-phenylalanine metabolic process (GO:0006558)7.19880274
6aromatic amino acid family catabolic process (GO:0009074)6.76295936
7epoxygenase P450 pathway (GO:0019373)6.68350812
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.40867024
9omega-hydroxylase P450 pathway (GO:0097267)6.27028699
10indole-containing compound catabolic process (GO:0042436)6.08589910
11indolalkylamine catabolic process (GO:0046218)6.08589910
12tryptophan catabolic process (GO:0006569)6.08589910
13kynurenine metabolic process (GO:0070189)5.99521631
14bile acid biosynthetic process (GO:0006699)5.94697653
15negative regulation of fibrinolysis (GO:0051918)5.82792127
16glyoxylate metabolic process (GO:0046487)5.75473218
17tryptophan metabolic process (GO:0006568)5.73841990
18high-density lipoprotein particle remodeling (GO:0034375)5.69092622
19urea cycle (GO:0000050)5.68828443
20urea metabolic process (GO:0019627)5.68828443
21regulation of fibrinolysis (GO:0051917)5.66386824
22alpha-linolenic acid metabolic process (GO:0036109)5.53893782
23regulation of plasminogen activation (GO:0010755)5.52224168
24protein carboxylation (GO:0018214)5.45179221
25peptidyl-glutamic acid carboxylation (GO:0017187)5.45179221
26complement activation, alternative pathway (GO:0006957)5.44021095
27* regulation of protein activation cascade (GO:2000257)5.35483036
28cysteine metabolic process (GO:0006534)5.33618928
29sulfur amino acid catabolic process (GO:0000098)5.25817161
30nitrogen cycle metabolic process (GO:0071941)5.23612574
31drug metabolic process (GO:0017144)5.17222093
32bile acid metabolic process (GO:0008206)5.06631086
33serine family amino acid catabolic process (GO:0009071)5.03399416
34oxidative demethylation (GO:0070989)5.02612731
35reverse cholesterol transport (GO:0043691)5.00684634
36regulation of cholesterol esterification (GO:0010872)4.97627815
37phenylpropanoid metabolic process (GO:0009698)4.96804769
38* regulation of complement activation (GO:0030449)4.94007296
39positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.93579370
40aromatic amino acid family metabolic process (GO:0009072)4.89929724
41protein-lipid complex remodeling (GO:0034368)4.89277084
42macromolecular complex remodeling (GO:0034367)4.89277084
43plasma lipoprotein particle remodeling (GO:0034369)4.89277084
44regulation of triglyceride catabolic process (GO:0010896)4.88362152
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84781787
46tyrosine metabolic process (GO:0006570)4.78183486
47homocysteine metabolic process (GO:0050667)4.77081804
48acylglycerol homeostasis (GO:0055090)4.66476550
49triglyceride homeostasis (GO:0070328)4.66476550
50phospholipid efflux (GO:0033700)4.66465536
51negative regulation of cholesterol transport (GO:0032375)4.64567086
52negative regulation of sterol transport (GO:0032372)4.64567086
53* negative regulation of hemostasis (GO:1900047)4.63244885
54* negative regulation of blood coagulation (GO:0030195)4.63244885
55alpha-amino acid catabolic process (GO:1901606)4.60170902
56lysine metabolic process (GO:0006553)4.51404003
57lysine catabolic process (GO:0006554)4.51404003
58amino-acid betaine metabolic process (GO:0006577)4.49619565
59plasma lipoprotein particle clearance (GO:0034381)4.46994064
60cellular ketone body metabolic process (GO:0046950)4.35269054
61bile acid and bile salt transport (GO:0015721)4.34355080
62cholesterol efflux (GO:0033344)4.32942371
63glycine metabolic process (GO:0006544)4.30730391
64indolalkylamine metabolic process (GO:0006586)4.30498546
65coenzyme catabolic process (GO:0009109)4.30163975
66glutamate metabolic process (GO:0006536)4.27360931
67imidazole-containing compound metabolic process (GO:0052803)4.24833159
68* negative regulation of coagulation (GO:0050819)4.23428565
69amine catabolic process (GO:0009310)4.23086401
70cellular biogenic amine catabolic process (GO:0042402)4.23086401
71cellular amino acid catabolic process (GO:0009063)4.23026126
72positive regulation of blood coagulation (GO:0030194)4.22749695
73positive regulation of hemostasis (GO:1900048)4.22749695
74intestinal cholesterol absorption (GO:0030299)4.21718326
75* negative regulation of wound healing (GO:0061045)4.17974337
76fibrinolysis (GO:0042730)4.17861601
77ethanol metabolic process (GO:0006067)4.17423905
78regulation of lipoprotein particle clearance (GO:0010984)4.13393016
79cellular glucuronidation (GO:0052695)4.11319061
80serine family amino acid metabolic process (GO:0009069)4.10422824
81cellular modified amino acid catabolic process (GO:0042219)4.10042291
82plasma lipoprotein particle assembly (GO:0034377)4.09862544
83arginine metabolic process (GO:0006525)4.08195713
84dicarboxylic acid biosynthetic process (GO:0043650)4.06806869
85protein-lipid complex subunit organization (GO:0071825)4.06644949
86low-density lipoprotein particle remodeling (GO:0034374)4.05679267
87benzene-containing compound metabolic process (GO:0042537)4.05085889
88* regulation of humoral immune response (GO:0002920)4.02834121
89blood coagulation, intrinsic pathway (GO:0007597)3.99785759
90serine family amino acid biosynthetic process (GO:0009070)3.96223670
91ethanol oxidation (GO:0006069)3.94536194
92alkaloid metabolic process (GO:0009820)3.92000857
93aldehyde catabolic process (GO:0046185)3.91037701
94positive regulation of coagulation (GO:0050820)3.90512201
95drug catabolic process (GO:0042737)3.88580771
96negative regulation of lipase activity (GO:0060192)3.83948365
97positive regulation of lipoprotein lipase activity (GO:0051006)3.81356196
98positive regulation of triglyceride lipase activity (GO:0061365)3.81356196
99phospholipid homeostasis (GO:0055091)3.79185783
100protein activation cascade (GO:0072376)3.79039648
101complement activation, classical pathway (GO:0006958)3.78995117
102positive regulation of lipid catabolic process (GO:0050996)3.77413470
103very-low-density lipoprotein particle assembly (GO:0034379)3.76894165
104cofactor catabolic process (GO:0051187)3.76884646
105ketone body metabolic process (GO:1902224)3.76312469
106cholesterol homeostasis (GO:0042632)3.76289845
107complement activation (GO:0006956)3.75918534
108S-adenosylmethionine metabolic process (GO:0046500)3.72400026
109cytolysis (GO:0019835)3.71454976
110plasma lipoprotein particle organization (GO:0071827)3.70587033
111heme transport (GO:0015886)3.70381624
112sterol homeostasis (GO:0055092)3.69541904
113carboxylic acid catabolic process (GO:0046395)3.68740056
114organic acid catabolic process (GO:0016054)3.68740056
115positive regulation of fatty acid biosynthetic process (GO:0045723)3.67313981
116regulation of bile acid biosynthetic process (GO:0070857)3.66190493
117protein-lipid complex assembly (GO:0065005)3.65743207
118glucuronate metabolic process (GO:0019585)3.64116567
119uronic acid metabolic process (GO:0006063)3.64116567
120short-chain fatty acid metabolic process (GO:0046459)3.63521640
121hormone catabolic process (GO:0042447)3.62211147
122regulation of cholesterol homeostasis (GO:2000188)3.60125413
123negative regulation of protein activation cascade (GO:2000258)3.60070008
124acute-phase response (GO:0006953)3.58930927
125negative regulation of fatty acid biosynthetic process (GO:0045717)3.56417475
126acute inflammatory response (GO:0002526)3.47120118
127lipoprotein metabolic process (GO:0042157)3.44473358
128negative regulation of lipid transport (GO:0032369)3.42527143
129flavonoid metabolic process (GO:0009812)3.42287720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.27895366
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.05677337
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.91416290
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.42928896
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.26984510
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.03880079
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.68307687
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02219674
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.78747354
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03816080
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9029666
12* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88599049
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85652264
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.66276724
15CLOCK_20551151_ChIP-Seq_293T_Human1.57860229
16HTT_18923047_ChIP-ChIP_STHdh_Human1.57190746
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40796928
18HNF4A_19822575_ChIP-Seq_HepG2_Human1.38946360
19GATA1_22025678_ChIP-Seq_K562_Human1.31698366
20RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17098215
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12060797
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09322517
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00756926
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00554981
25GATA6_25053715_ChIP-Seq_YYC3_Human0.99347096
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97800544
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96631087
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95107105
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93499203
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89652593
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88421040
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86547674
33SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86428614
34RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85670885
35AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81525315
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75604210
37* GATA4_25053715_ChIP-Seq_YYC3_Human0.75096690
38SOX2_20726797_ChIP-Seq_SW620_Human0.74427503
39SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72643437
40RARA_24833708_ChIP-Seq_LIVER_Mouse0.71883625
41NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71816200
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71816200
43ESR2_21235772_ChIP-Seq_MCF-7_Human0.71627256
44SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71009311
45KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70858231
46AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70585735
47ZNF263_19887448_ChIP-Seq_K562_Human0.70525990
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.68904863
49SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68824948
50SOX2_21211035_ChIP-Seq_LN229_Human0.68056762
51SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67937355
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67311314
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66696884
54BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66297769
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64966660
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.64722836
57EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.64217567
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64093840
59TCF4_18268006_ChIP-ChIP_LS174T_Human0.63828910
60NFE2_27457419_Chip-Seq_LIVER_Mouse0.63341389
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.62185830
62IRF8_22096565_ChIP-ChIP_GC-B_Human0.61962962
63RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60690063
64RARB_24833708_ChIP-Seq_LIVER_Mouse0.58699333
65EGR1_19032775_ChIP-ChIP_M12_Human0.58635891
66HNFA_21074721_ChIP-Seq_CACO-2_Human0.58564725
67* RAC3_21632823_ChIP-Seq_H3396_Human0.58276518
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57651674
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57460873
70CEBPB_22108803_ChIP-Seq_LS180_Human0.57158489
71CTCF_27219007_Chip-Seq_Bcells_Human0.56327091
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55701364
73ERG_21242973_ChIP-ChIP_JURKAT_Human0.55144131
74LXR_22292898_ChIP-Seq_THP-1_Human0.54439393
75FOXA1_25552417_ChIP-Seq_VCAP_Human0.54438860
76JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.54241663
77AR_20517297_ChIP-Seq_VCAP_Human0.54180541
78ELF1_20517297_ChIP-Seq_JURKAT_Human0.53967050
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.53547605
80TP53_18474530_ChIP-ChIP_U2OS_Human0.53454536
81POU5F1_16518401_ChIP-PET_MESCs_Mouse0.53224652
82TAF15_26573619_Chip-Seq_HEK293_Human0.52968522
83CBP_21632823_ChIP-Seq_H3396_Human0.52295423
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.52193849
85PHF8_20622853_ChIP-Seq_HELA_Human0.51234027
86MYC_19915707_ChIP-ChIP_AK7_Human0.50448221
87GATA1_19941826_ChIP-Seq_K562_Human0.50200808
88FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49875449
89BCAT_22108803_ChIP-Seq_LS180_Human0.49575707
90ESET_19884257_ChIP-Seq_ESCs_Mouse0.49350358
91SMC4_20622854_ChIP-Seq_HELA_Human0.48759621
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.48701013
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.48420074
94CDX2_19796622_ChIP-Seq_MESCs_Mouse0.48123343
95STAT1_17558387_ChIP-Seq_HELA_Human0.47958041
96SPI1_20517297_ChIP-Seq_HL60_Human0.47817422
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.47812976
98FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47463018
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.47250616
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.46944881
101GATA3_24758297_ChIP-Seq_MCF-7_Human0.46859637
102P53_21459846_ChIP-Seq_SAOS-2_Human0.46600982
103SMAD1_18555785_Chip-Seq_ESCs_Mouse0.46410986
104GATA3_21867929_ChIP-Seq_CD8_Mouse0.46346497
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.45938319
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.45818163
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.45778167
108CDX2_20551321_ChIP-Seq_CACO-2_Human0.45508882
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.44759067
110MYC_27129775_Chip-Seq_CORNEA_Mouse0.44088742
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.44023165
112TAF2_19829295_ChIP-Seq_ESCs_Human0.43381251
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.43351796
114GATA2_19941826_ChIP-Seq_K562_Human0.42882244
115PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42830129
116* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42506569
117* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41339125
118STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40748980
119TRIM28_21343339_ChIP-Seq_HEK293_Human0.40690522
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.40456580
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39322041
122LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.37501680
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.37451052
124NCOR_22424771_ChIP-Seq_293T_Human0.36711927
125FOXH1_21741376_ChIP-Seq_EPCs_Human0.35650568
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.35073058
127CDX2_22108803_ChIP-Seq_LS180_Human0.34272003
128CSB_26484114_Chip-Seq_FIBROBLAST_Human0.34079226
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34047157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.20486739
2MP0005360_urolithiasis7.47279336
3MP0005085_abnormal_gallbladder_physiolo6.51668226
4MP0005365_abnormal_bile_salt6.26440614
5MP0008875_abnormal_xenobiotic_pharmacok5.02676696
6MP0003806_abnormal_nucleotide_metabolis4.16163892
7MP0003252_abnormal_bile_duct3.89308665
8MP0010329_abnormal_lipoprotein_level3.63871383
9MP0009840_abnormal_foam_cell3.28554170
10MP0005083_abnormal_biliary_tract3.20893606
11MP0003195_calcinosis2.77994520
12MP0005332_abnormal_amino_acid2.74960879
13MP0001666_abnormal_nutrient_absorption2.67048669
14MP0003191_abnormal_cellular_cholesterol2.31711262
15MP0004019_abnormal_vitamin_homeostasis2.16605392
16MP0000609_abnormal_liver_physiology2.12513326
17MP0002118_abnormal_lipid_homeostasis2.09129776
18MP0003868_abnormal_feces_composition1.99179627
19MP0003011_delayed_dark_adaptation1.96127288
20MP0002138_abnormal_hepatobiliary_system1.95980385
21MP0005319_abnormal_enzyme/_coenzyme1.77702933
22MP0001764_abnormal_homeostasis1.77248082
23MP0009697_abnormal_copulation1.66777209
24MP0005584_abnormal_enzyme/coenzyme_acti1.52573978
25MP0005451_abnormal_body_composition1.30643657
26MP0010368_abnormal_lymphatic_system1.24780398
27MP0003656_abnormal_erythrocyte_physiolo1.19342213
28MP0003186_abnormal_redox_activity1.19118009
29MP0009643_abnormal_urine_homeostasis1.18096237
30MP0000598_abnormal_liver_morphology1.15555833
31MP0005647_abnormal_sex_gland1.08563975
32MP0003705_abnormal_hypodermis_morpholog1.08381889
33MP0000604_amyloidosis1.05734662
34MP0009764_decreased_sensitivity_to1.04588231
35MP0002254_reproductive_system_inflammat1.02104210
36MP0009763_increased_sensitivity_to1.01087445
37MP0001915_intracranial_hemorrhage0.98533380
38MP0005084_abnormal_gallbladder_morpholo0.97805592
39MP0002132_abnormal_respiratory_system0.96080390
40MP0005058_abnormal_lysosome_morphology0.95885386
41MP0000566_synostosis0.94690012
42MP0005636_abnormal_mineral_homeostasis0.89604824
43MP0005408_hypopigmentation0.88954221
44* MP0009642_abnormal_blood_homeostasis0.84407166
45MP0008469_abnormal_protein_level0.84004522
46MP0003879_abnormal_hair_cell0.79333910
47* MP0005376_homeostasis/metabolism_phenot0.78086230
48MP0005220_abnormal_exocrine_pancreas0.77935035
49MP0009765_abnormal_xenobiotic_induced0.75656945
50MP0002078_abnormal_glucose_homeostasis0.75653349
51MP0009053_abnormal_anal_canal0.74559383
52MP0005670_abnormal_white_adipose0.72065421
53MP0004130_abnormal_muscle_cell0.71753383
54MP0006036_abnormal_mitochondrial_physio0.71603968
55MP0002089_abnormal_postnatal_growth/wei0.69879412
56MP0003690_abnormal_glial_cell0.69645293
57MP0002876_abnormal_thyroid_physiology0.69082132
58MP0005187_abnormal_penis_morphology0.68666540
59MP0001661_extended_life_span0.68398093
60MP0002971_abnormal_brown_adipose0.67929284
61MP0005535_abnormal_body_temperature0.64818060
62MP0005266_abnormal_metabolism0.62836450
63MP0005334_abnormal_fat_pad0.61803752
64MP0000639_abnormal_adrenal_gland0.60119138
65MP0003329_amyloid_beta_deposits0.59275003
66MP0004272_abnormal_basement_membrane0.58809596
67MP0002822_catalepsy0.57113265
68MP0005023_abnormal_wound_healing0.54404476
69MP0009384_cardiac_valve_regurgitation0.54304091
70MP0005448_abnormal_energy_balance0.53916483
71MP0002928_abnormal_bile_duct0.53731329
72MP0001756_abnormal_urination0.53033121
73MP0002282_abnormal_trachea_morphology0.52397890
74MP0003638_abnormal_response/metabolism_0.50574464
75MP0005551_abnormal_eye_electrophysiolog0.49208847
76MP0006035_abnormal_mitochondrial_morpho0.47712864
77MP0001986_abnormal_taste_sensitivity0.46760549
78MP0005167_abnormal_blood-brain_barrier0.45800185
79MP0005395_other_phenotype0.45754961
80MP0003122_maternal_imprinting0.45468159
81MP0008874_decreased_physiological_sensi0.43639012
82MP0008873_increased_physiological_sensi0.42910294
83MP0003075_altered_response_to0.42888571
84MP0003718_maternal_effect0.40102743
85MP0003724_increased_susceptibility_to0.39926052
86MP0004782_abnormal_surfactant_physiolog0.39925704
87MP0002090_abnormal_vision0.39908995
88MP0002136_abnormal_kidney_physiology0.39677172
89MP0002837_dystrophic_cardiac_calcinosis0.38647965
90MP0003953_abnormal_hormone_level0.38405313
91MP0004883_abnormal_blood_vessel0.38252632
92MP0005166_decreased_susceptibility_to0.37286513
93MP0002249_abnormal_larynx_morphology0.37071618
94MP0008872_abnormal_physiological_respon0.36524845
95MP0001324_abnormal_eye_pigmentation0.35831599
96MP0000230_abnormal_systemic_arterial0.35570586
97MP0004381_abnormal_hair_follicle0.35308826
98MP0010386_abnormal_urinary_bladder0.34866449
99* MP0005464_abnormal_platelet_physiology0.34592879
100MP0000249_abnormal_blood_vessel0.34496680
101MP0000579_abnormal_nail_morphology0.33797602
102MP0005248_abnormal_Harderian_gland0.33440452
103MP0001243_abnormal_dermal_layer0.32650179
104MP0003941_abnormal_skin_development0.32346737
105MP0005666_abnormal_adipose_tissue0.32259729
106MP0000920_abnormal_myelination0.30459943
107MP0003632_abnormal_nervous_system0.29815003
108MP0005595_abnormal_vascular_smooth0.29717337
109MP0009672_abnormal_birth_weight0.28700811
110MP0002168_other_aberrant_phenotype0.28620135
111MP0003436_decreased_susceptibility_to0.28088314
112MP0009115_abnormal_fat_cell0.27409958
113MP0002796_impaired_skin_barrier0.26255435
114MP0004147_increased_porphyrin_level0.24505820
115MP0003878_abnormal_ear_physiology0.24113005
116MP0005377_hearing/vestibular/ear_phenot0.24113005
117MP0002970_abnormal_white_adipose0.24109080
118MP0001881_abnormal_mammary_gland0.23628551
119MP0001853_heart_inflammation0.23476275
120MP0002909_abnormal_adrenal_gland0.23030742
121MP0005409_darkened_coat_color0.22304510
122MP0000467_abnormal_esophagus_morphology0.22024297
123* MP0005164_abnormal_response_to0.21165783
124MP0009785_altered_susceptibility_to0.20864024
125MP0001944_abnormal_pancreas_morphology0.20753614
126MP0002128_abnormal_blood_circulation0.20345824

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.59435473
2Intrahepatic cholestasis (HP:0001406)7.34142627
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.31340196
4Prolonged partial thromboplastin time (HP:0003645)6.76215609
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.63622055
6Hypobetalipoproteinemia (HP:0003563)6.38658647
7Xanthomatosis (HP:0000991)6.30804154
8Hyperlipoproteinemia (HP:0010980)5.66853382
9Complement deficiency (HP:0004431)5.51793357
10Joint hemorrhage (HP:0005261)4.88573915
11Hypolipoproteinemia (HP:0010981)4.86443008
12Abnormality of the common coagulation pathway (HP:0010990)4.67702546
13Hyperammonemia (HP:0001987)4.55562229
14Epidermoid cyst (HP:0200040)4.47353871
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.45720563
16Hyperglycinemia (HP:0002154)4.36807475
17Hypoalphalipoproteinemia (HP:0003233)4.32310575
18Abnormality of methionine metabolism (HP:0010901)4.24441700
19Ketosis (HP:0001946)4.21052501
20Fat malabsorption (HP:0002630)4.19232424
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.18292391
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08350661
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.03333368
24Abnormality of complement system (HP:0005339)3.98678836
25Hypoglycemic coma (HP:0001325)3.92681960
26Abnormality of the intrinsic pathway (HP:0010989)3.85511342
27Abnormality of glycine metabolism (HP:0010895)3.84472701
28Abnormality of serine family amino acid metabolism (HP:0010894)3.84472701
29Hyperglycinuria (HP:0003108)3.83355858
30Conjugated hyperbilirubinemia (HP:0002908)3.79615820
31Abnormality of pyrimidine metabolism (HP:0004353)3.71127329
32Hypercholesterolemia (HP:0003124)3.62069724
33Hyperbilirubinemia (HP:0002904)3.35568887
34Spontaneous abortion (HP:0005268)3.26565789
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22492158
36Abnormality of fatty-acid metabolism (HP:0004359)3.21368103
37Steatorrhea (HP:0002570)3.14654227
38Delayed CNS myelination (HP:0002188)3.05681076
39Hypochromic microcytic anemia (HP:0004840)3.02516630
40Abnormality of serum amino acid levels (HP:0003112)3.01589176
41Hepatocellular carcinoma (HP:0001402)3.01331236
42Ketoacidosis (HP:0001993)2.96478164
43Abnormality of nucleobase metabolism (HP:0010932)2.94693414
44Myocardial infarction (HP:0001658)2.92317805
45Osteomalacia (HP:0002749)2.84498981
46Skin nodule (HP:0200036)2.78669394
47Systemic lupus erythematosus (HP:0002725)2.71731462
48Metabolic acidosis (HP:0001942)2.71573772
49Hypoglycemic seizures (HP:0002173)2.59810495
50Purpura (HP:0000979)2.58760650
51Abnormality of purine metabolism (HP:0004352)2.56476456
52Lethargy (HP:0001254)2.56189167
53Acanthocytosis (HP:0001927)2.56094760
54Glomerulonephritis (HP:0000099)2.54289651
55Vascular calcification (HP:0004934)2.50822222
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48434807
57Dicarboxylic aciduria (HP:0003215)2.48434807
58Abnormal gallbladder morphology (HP:0012437)2.47095111
59Abnormal gallbladder physiology (HP:0012438)2.45611781
60Cholecystitis (HP:0001082)2.45611781
61Cholelithiasis (HP:0001081)2.42387961
62Amyloidosis (HP:0011034)2.41374158
63Gout (HP:0001997)2.40448372
64Cerebral edema (HP:0002181)2.39835141
65Spastic diplegia (HP:0001264)2.38777674
66Abnormality of the Achilles tendon (HP:0005109)2.37739973
67Mitral stenosis (HP:0001718)2.37411241
68Neonatal onset (HP:0003623)2.34367516
69Recurrent gram-negative bacterial infections (HP:0005420)2.33080100
70Esophageal varix (HP:0002040)2.31911865
71Reduced antithrombin III activity (HP:0001976)2.30733871
72Arthropathy (HP:0003040)2.28777792
73Irritability (HP:0000737)2.28707958
74Gingival bleeding (HP:0000225)2.25761393
75Cardiovascular calcification (HP:0011915)2.21402370
76Retinal atrophy (HP:0001105)2.19164412
77Malnutrition (HP:0004395)2.18089321
78Joint swelling (HP:0001386)2.17879172
79Sensorimotor neuropathy (HP:0007141)2.16939392
80Pulmonary embolism (HP:0002204)2.16896607
81Menorrhagia (HP:0000132)2.13781757
82Thrombophlebitis (HP:0004418)2.12713392
83Pancreatitis (HP:0001733)2.11810433
84Glycosuria (HP:0003076)2.11228499
85Abnormality of urine glucose concentration (HP:0011016)2.11228499
86Enlarged kidneys (HP:0000105)2.10791527
87Hyperinsulinemic hypoglycemia (HP:0000825)2.09533163
88Poikilocytosis (HP:0004447)2.05130896
89Hyperphosphaturia (HP:0003109)2.03986793
90Vomiting (HP:0002013)2.03473099
91Late onset (HP:0003584)2.02626680
92Abnormality of the gallbladder (HP:0005264)2.00880761
93Hemorrhage of the eye (HP:0011885)2.00478201
94Fair hair (HP:0002286)2.00188439
95Brushfield spots (HP:0001088)1.99207384
96Abnormal delivery (HP:0001787)1.99040920
97Abnormality of iron homeostasis (HP:0011031)1.98444372
98Generalized aminoaciduria (HP:0002909)1.95006859
99Abnormality of transition element cation homeostasis (HP:0011030)1.94362698
100Rickets (HP:0002748)1.93132730
101Increased serum ferritin (HP:0003281)1.92814295
102Opisthotonus (HP:0002179)1.90392022
103Epistaxis (HP:0000421)1.90300206
104Elevated alkaline phosphatase (HP:0003155)1.89019925
105Hypophosphatemic rickets (HP:0004912)1.88770724
106Status epilepticus (HP:0002133)1.87333128
107Nephritis (HP:0000123)1.85299853
108Pigmentary retinal degeneration (HP:0001146)1.84744942
109Bifid scrotum (HP:0000048)1.81478876
110Elevated hepatic transaminases (HP:0002910)1.80058819
111Abnormal cartilage morphology (HP:0002763)1.79440607
112Abnormality of alkaline phosphatase activity (HP:0004379)1.78865715
113Alkalosis (HP:0001948)1.77835868
114Abnormal enzyme/coenzyme activity (HP:0012379)1.72952466
115Renal cortical cysts (HP:0000803)1.72344215
116Abnormality of vitamin metabolism (HP:0100508)1.71680356
117Reticulocytosis (HP:0001923)1.71274866
118Hydroxyprolinuria (HP:0003080)1.69571595
119Abnormal urine phosphate concentration (HP:0012599)1.65891789
120Gangrene (HP:0100758)1.64922275
121Increased serum pyruvate (HP:0003542)1.64759503
122Abnormality of proline metabolism (HP:0010907)1.63456764
123Proximal tubulopathy (HP:0000114)1.61286676
124Potter facies (HP:0002009)1.55205080
125Facial shape deformation (HP:0011334)1.55205080
126Back pain (HP:0003418)1.53847085
127Abnormal tarsal ossification (HP:0008369)1.52142418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.04418976
2FGFR44.44383099
3SIK14.35686949
4ERN14.27761399
5PDK24.02047845
6INSRR3.09069778
7TAOK32.95636522
8ERBB42.87940855
9MAP2K42.37609157
10NTRK32.06527028
11MST1R1.96528399
12PKN21.89455613
13MAPK111.89390137
14MUSK1.84110889
15DAPK21.75561594
16MAP3K121.72923387
17PIK3CG1.69452508
18FGFR21.60519742
19LATS11.60330141
20KDR1.57824712
21TYK21.57247890
22FLT31.56177160
23ABL21.53677193
24FRK1.51764221
25TESK21.51756894
26GRK11.48663226
27TRIB31.45336321
28PTK61.44687668
29TIE11.37600954
30LMTK21.31542164
31PRKAA21.29334295
32NEK91.27719382
33MAP3K21.27148003
34PINK11.23486608
35ERBB21.22958006
36JAK21.16453730
37MAP3K71.10424214
38EPHA21.09178048
39PRPF4B1.06739533
40PRKCZ1.01398609
41GRK61.00334269
42FGFR11.00043246
43MAP2K30.99766676
44MAPK120.99606786
45MAPK150.98493259
46MAPK40.95084941
47JAK10.90902857
48MAP3K100.90563562
49CAMK1D0.90003064
50MAP3K110.89629398
51TBK10.89446113
52PBK0.84318515
53MET0.82572266
54EPHA40.82312012
55MAPK70.79838755
56CAMK2G0.79453102
57EPHB20.78776208
58PRKG10.76400032
59IRAK30.76203041
60DYRK1B0.74336249
61* PRKACG0.72410731
62MAP3K30.72030956
63PRKAA10.69291088
64GSK3A0.68881785
65NLK0.68566346
66MAP3K140.68173333
67TGFBR20.67214090
68CDK60.64999455
69CDK120.64353788
70FER0.63432365
71ACVR1B0.62821233
72CAMK1G0.62567182
73EPHB10.62221330
74SGK30.61436867
75NUAK10.59051337
76RIPK10.57861540
77CSK0.57424259
78MAP2K10.56283062
79MAP2K60.56237535
80WNK30.55657487
81PTK20.55532096
82STK38L0.54689368
83PKN10.54556862
84PRKCQ0.54068166
85PAK30.53977392
86PDPK10.53334439
87* PRKACA0.53187267
88EPHA30.52868673
89CSNK1E0.52715322
90FGFR30.51500058
91MYLK0.50625319
92SCYL20.49976938
93RET0.48918894
94STK160.48380418
95SGK20.47236738
96SGK10.46462303
97IRAK20.46360108
98IGF1R0.46127956
99SRC0.45742174
100EIF2AK10.44738268
101CAMK40.43162084
102IKBKE0.43122914
103SGK2230.41962041
104SGK4940.41962041
105AKT30.40887497
106PDGFRA0.40848254
107CSNK1G10.40772777
108MAPKAPK30.40340575
109ZAP700.38886984
110AKT20.38671657
111CSF1R0.37563896
112ICK0.37338377
113STK380.36324859
114* PRKCB0.36171401
115MAP2K20.35126094
116WNK40.34546062
117EGFR0.34210022
118MTOR0.32892350
119MAP3K50.30647458
120MAP3K10.30054654
121CSNK1G20.29858935
122CSNK1A10.29465255
123RPS6KB10.29352622
124KSR20.29234740
125* CSNK2A10.29223515
126CDK90.29140615
127* PRKCA0.28880712
128CASK0.28237585
129KIT0.28183364
130* RPS6KA30.27165265
131PRKACB0.26956222
132CDK40.26774598
133MAP3K60.25675551
134PIK3CA0.25125863
135TAOK20.25054808
136PDK10.24245770
137IRAK10.24216847

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.57606556
2Nitrogen metabolism_Homo sapiens_hsa009103.83830497
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46364767
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28347051
5Arginine biosynthesis_Homo sapiens_hsa002203.18327672
6* Complement and coagulation cascades_Homo sapiens_hsa046102.84385791
7Tryptophan metabolism_Homo sapiens_hsa003802.67480111
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65067409
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61506723
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57631101
11Fatty acid degradation_Homo sapiens_hsa000712.45669655
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34349265
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15598716
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11150390
15Butanoate metabolism_Homo sapiens_hsa006502.09402725
16Peroxisome_Homo sapiens_hsa041462.02892775
17Chemical carcinogenesis_Homo sapiens_hsa052041.92596675
18Propanoate metabolism_Homo sapiens_hsa006401.90397658
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.89254523
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88804725
21Histidine metabolism_Homo sapiens_hsa003401.87335203
22PPAR signaling pathway_Homo sapiens_hsa033201.85715772
23Staphylococcus aureus infection_Homo sapiens_hsa051501.78552313
24Fatty acid metabolism_Homo sapiens_hsa012121.78218728
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74960327
26Caffeine metabolism_Homo sapiens_hsa002321.72201959
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.70159341
28Retinol metabolism_Homo sapiens_hsa008301.69657389
29beta-Alanine metabolism_Homo sapiens_hsa004101.64883544
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59595178
31Phenylalanine metabolism_Homo sapiens_hsa003601.56821841
32Bile secretion_Homo sapiens_hsa049761.54879245
33Selenocompound metabolism_Homo sapiens_hsa004501.53980167
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53472206
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49971019
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48193110
37Tyrosine metabolism_Homo sapiens_hsa003501.42680811
38Pyruvate metabolism_Homo sapiens_hsa006201.32615363
39Fatty acid elongation_Homo sapiens_hsa000621.31661575
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.29059573
41Sulfur metabolism_Homo sapiens_hsa009201.28310545
42ABC transporters_Homo sapiens_hsa020101.26938995
43Starch and sucrose metabolism_Homo sapiens_hsa005001.26745560
44Fat digestion and absorption_Homo sapiens_hsa049751.24450109
45Biosynthesis of amino acids_Homo sapiens_hsa012301.19358566
46Steroid biosynthesis_Homo sapiens_hsa001001.17067688
47Folate biosynthesis_Homo sapiens_hsa007901.16617250
48Carbon metabolism_Homo sapiens_hsa012001.08723324
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08429731
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.07650685
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.03540279
52Arginine and proline metabolism_Homo sapiens_hsa003300.98477569
53Vitamin B6 metabolism_Homo sapiens_hsa007500.96019628
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95548568
55Sulfur relay system_Homo sapiens_hsa041220.94199998
56Vitamin digestion and absorption_Homo sapiens_hsa049770.93065853
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91116987
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85086452
59Lysine degradation_Homo sapiens_hsa003100.79335943
60Glycerolipid metabolism_Homo sapiens_hsa005610.69488730
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68018240
62One carbon pool by folate_Homo sapiens_hsa006700.65944757
63Glutathione metabolism_Homo sapiens_hsa004800.62651453
64Fatty acid biosynthesis_Homo sapiens_hsa000610.51888828
65Pentose phosphate pathway_Homo sapiens_hsa000300.51398127
66Other glycan degradation_Homo sapiens_hsa005110.45001321
67Metabolic pathways_Homo sapiens_hsa011000.44087959
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40227001
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39804691
70Prion diseases_Homo sapiens_hsa050200.37789352
71Pertussis_Homo sapiens_hsa051330.28186019
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25220672
73Galactose metabolism_Homo sapiens_hsa000520.22494847
74Fructose and mannose metabolism_Homo sapiens_hsa000510.22296169
75Insulin resistance_Homo sapiens_hsa049310.22238363
76Linoleic acid metabolism_Homo sapiens_hsa005910.21706962
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.20461274
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.17370413
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16224640
80Glucagon signaling pathway_Homo sapiens_hsa049220.10846925
81Sphingolipid metabolism_Homo sapiens_hsa006000.07624872
82Mineral absorption_Homo sapiens_hsa049780.04849933
83AMPK signaling pathway_Homo sapiens_hsa041520.00798140
84Phototransduction_Homo sapiens_hsa047440.00642327
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2370633
86Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2295118
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2282273
88Amoebiasis_Homo sapiens_hsa05146-0.2251986
89Lysosome_Homo sapiens_hsa04142-0.2149969
90Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2085512
91Hepatitis C_Homo sapiens_hsa05160-0.2064474
92Renin-angiotensin system_Homo sapiens_hsa04614-0.2017143
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1942030
94Regulation of autophagy_Homo sapiens_hsa04140-0.1881012
95Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1849694
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1684064
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1586575
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1494093
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1493692
100Ether lipid metabolism_Homo sapiens_hsa00565-0.1470829
101Serotonergic synapse_Homo sapiens_hsa04726-0.1286474
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1200306
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1153437
104African trypanosomiasis_Homo sapiens_hsa05143-0.1023908
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0524740
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0378793
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0361068
108N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0301486

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