VWA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: VWA1 belongs to the von Willebrand factor (VWF; MIM 613160) A (VWFA) domain superfamily of extracellular matrix proteins and appears to play a role in cartilage structure and function (Fitzgerald et al., 2002 [PubMed 12062410]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.54362057
2peptidyl-tyrosine autophosphorylation (GO:0038083)5.23715528
3desmosome organization (GO:0002934)4.97785737
4endothelium development (GO:0003158)4.73798295
5regulation of cholesterol biosynthetic process (GO:0045540)4.25068966
6semaphorin-plexin signaling pathway (GO:0071526)3.81679361
7retina vasculature morphogenesis in camera-type eye (GO:0061299)3.80328722
8vascular endothelial growth factor signaling pathway (GO:0038084)3.78993108
9cytoskeletal anchoring at plasma membrane (GO:0007016)3.73136569
10regulation of vasculogenesis (GO:2001212)3.50400840
11protein retention in ER lumen (GO:0006621)3.48126820
12positive regulation of vasculogenesis (GO:2001214)3.48066998
13cell-cell junction maintenance (GO:0045217)3.41644955
14potassium ion import (GO:0010107)3.40286290
15basement membrane organization (GO:0071711)3.36869035
16epithelial cell-cell adhesion (GO:0090136)3.35696636
17central nervous system myelination (GO:0022010)3.32777128
18axon ensheathment in central nervous system (GO:0032291)3.32777128
19regulation of cholesterol homeostasis (GO:2000188)3.30781096
20regulation of cholesterol metabolic process (GO:0090181)3.30307367
21lung epithelium development (GO:0060428)3.28941435
22sodium-independent organic anion transport (GO:0043252)3.25582644
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.23584773
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23433973
25surfactant homeostasis (GO:0043129)3.22457036
26cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.19465311
27vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.18373551
28endothelial cell differentiation (GO:0045446)3.12469872
29bundle of His cell to Purkinje myocyte communication (GO:0086069)3.08395267
30regulation of apoptotic cell clearance (GO:2000425)3.06318564
31negative regulation of protein localization to cell surface (GO:2000009)3.06092552
32regulation of glucose import in response to insulin stimulus (GO:2001273)3.05699523
33layer formation in cerebral cortex (GO:0021819)3.05227470
34COPI coating of Golgi vesicle (GO:0048205)3.03448760
35Golgi transport vesicle coating (GO:0048200)3.03448760
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02405167
37L-phenylalanine metabolic process (GO:0006558)3.00844500
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.00844500
39lymphangiogenesis (GO:0001946)2.97418148
40regulation of extracellular matrix disassembly (GO:0010715)2.96192792
41negative regulation of catenin import into nucleus (GO:0035414)2.93992886
42proline metabolic process (GO:0006560)2.93094518
43activation of Rac GTPase activity (GO:0032863)2.88774453
44myelination in peripheral nervous system (GO:0022011)2.88534160
45peripheral nervous system axon ensheathment (GO:0032292)2.88534160
46protein carboxylation (GO:0018214)2.88109482
47peptidyl-glutamic acid carboxylation (GO:0017187)2.88109482
48hemidesmosome assembly (GO:0031581)2.86514339
49atrioventricular valve morphogenesis (GO:0003181)2.85338831
50adherens junction assembly (GO:0034333)2.81842468
51positive regulation of cellular amine metabolic process (GO:0033240)2.81734307
52proline biosynthetic process (GO:0006561)2.81676913
53cellular potassium ion homeostasis (GO:0030007)2.78852267
54chemical homeostasis within a tissue (GO:0048875)2.78137295
55cell junction maintenance (GO:0034331)2.76378106
56regulation of complement activation (GO:0030449)2.74587852
57regulation of protein activation cascade (GO:2000257)2.74216610
58cell volume homeostasis (GO:0006884)2.70117441
59establishment of apical/basal cell polarity (GO:0035089)2.70088235
60regulation of cardiac muscle cell contraction (GO:0086004)2.68803288
61regulation of cholesterol esterification (GO:0010872)2.67924671
62complement activation, classical pathway (GO:0006958)2.67901655
63branching involved in salivary gland morphogenesis (GO:0060445)2.67431868
64regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67142555
65amino acid import (GO:0043090)2.67089967
66regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.65721310
67multicellular organismal water homeostasis (GO:0050891)2.64972148
68apoptotic process involved in morphogenesis (GO:0060561)2.64686765
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62291804
70axon ensheathment (GO:0008366)2.62075119
71ensheathment of neurons (GO:0007272)2.62075119
72gamma-aminobutyric acid transport (GO:0015812)2.61424267
73retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59950673
74myelination (GO:0042552)2.58750615
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.58287804
76L-phenylalanine catabolic process (GO:0006559)2.58287804
77negative regulation of fatty acid transport (GO:2000192)2.56236822
78regulation of somitogenesis (GO:0014807)2.55344473
79neuronal action potential propagation (GO:0019227)2.55050701
80branching involved in mammary gland duct morphogenesis (GO:0060444)2.54611335
81negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.53357909
82cell-substrate adherens junction assembly (GO:0007045)2.53130702
83focal adhesion assembly (GO:0048041)2.53130702
84regulation of water loss via skin (GO:0033561)2.52167700
85gap junction assembly (GO:0016264)2.52090655
86calcium-mediated signaling using intracellular calcium source (GO:0035584)2.52004561
87photoreceptor cell differentiation (GO:0046530)2.51688650
88eye photoreceptor cell differentiation (GO:0001754)2.51688650
89endothelial cell morphogenesis (GO:0001886)2.51347925
90negative regulation of cell size (GO:0045792)2.50659793
91transcytosis (GO:0045056)2.50545365
92calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.49989568
93Notch signaling involved in heart development (GO:0061314)2.49971921
94neuronal ion channel clustering (GO:0045161)2.49178411
95L-amino acid import (GO:0043092)2.48110608
96embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48094268
97positive regulation of steroid metabolic process (GO:0045940)2.46962182
98positive regulation of synapse maturation (GO:0090129)2.46910900
99regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.45533941
100cell-substrate junction assembly (GO:0007044)2.44506690
101regulation of actin filament-based movement (GO:1903115)2.44054334
102peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.42236058
103negative regulation of Rho protein signal transduction (GO:0035024)2.41978160
104potassium ion homeostasis (GO:0055075)2.41731216
105heart trabecula formation (GO:0060347)2.40781237
106glomerular filtration (GO:0003094)2.40638007
107regulation of endothelial cell differentiation (GO:0045601)2.40305638
108adhesion of symbiont to host cell (GO:0044650)2.39532081
109virion attachment to host cell (GO:0019062)2.39532081
110positive regulation of steroid biosynthetic process (GO:0010893)2.38980333
111proline transport (GO:0015824)2.37897337
112regulation of extracellular matrix organization (GO:1903053)2.37550889
113regulation of dendritic spine morphogenesis (GO:0061001)2.35338567
114ventricular trabecula myocardium morphogenesis (GO:0003222)2.33643799
115sodium ion export (GO:0071436)2.33497769
116synaptic vesicle docking involved in exocytosis (GO:0016081)2.31497888
117complement activation, alternative pathway (GO:0006957)2.30887278
118positive regulation of triglyceride lipase activity (GO:0061365)2.30771974
119positive regulation of lipoprotein lipase activity (GO:0051006)2.30771974
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.30145080
121glutamine family amino acid biosynthetic process (GO:0009084)2.29839726
122renal filtration (GO:0097205)2.28984502
123triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.28671801
124maternal placenta development (GO:0001893)2.27922049
125cerebral cortex radially oriented cell migration (GO:0021799)2.26736368
126glutathione biosynthetic process (GO:0006750)2.25294884
127regulation of bile acid biosynthetic process (GO:0070857)2.23546384
128protein autoprocessing (GO:0016540)2.23003348
129biotin metabolic process (GO:0006768)2.22081391
130synaptic vesicle maturation (GO:0016188)2.22064885
131cell-cell junction assembly (GO:0007043)2.20991424
132renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.20716636
133negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.20522850
134embryonic heart tube development (GO:0035050)2.20048821
135positive regulation of dendritic spine morphogenesis (GO:0061003)2.19070214
136positive regulation of dendritic spine development (GO:0060999)2.18036783
137glycine transport (GO:0015816)2.17832833
138complement activation (GO:0006956)2.17753725
139ethanol metabolic process (GO:0006067)2.17197682
140retinal ganglion cell axon guidance (GO:0031290)2.16064464
141water homeostasis (GO:0030104)2.15534776
142regulation of fatty acid beta-oxidation (GO:0031998)2.14270925
143blood vessel maturation (GO:0001955)2.13866471
144bone morphogenesis (GO:0060349)2.13707020
145urea cycle (GO:0000050)2.12963366
146ethanol oxidation (GO:0006069)2.12839304
147regulation of dendritic spine development (GO:0060998)2.12764613
148regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.12182481
149patterning of blood vessels (GO:0001569)2.11766791
150establishment of monopolar cell polarity (GO:0061162)2.11472833
151establishment or maintenance of monopolar cell polarity (GO:0061339)2.11472833
152Rho protein signal transduction (GO:0007266)2.11462692
153positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.11413741
154adhesion of symbiont to host (GO:0044406)2.09483030
155membrane assembly (GO:0071709)2.09057056
156protein targeting to plasma membrane (GO:0072661)2.08318105
157regulation of axon extension involved in axon guidance (GO:0048841)2.08213739
158positive regulation of smooth muscle cell migration (GO:0014911)2.07217053
159alanine transport (GO:0032328)2.06687304
160L-serine transport (GO:0015825)2.06584261
161regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.04420083
162positive regulation of astrocyte differentiation (GO:0048711)2.03897648
163endothelial cell chemotaxis (GO:0035767)2.03876810
164endocardial cushion morphogenesis (GO:0003203)2.03794940
165establishment of planar polarity (GO:0001736)2.03779432
166establishment of tissue polarity (GO:0007164)2.03779432
167heart valve formation (GO:0003188)2.01908651
168positive regulation of potassium ion transport (GO:0043268)2.01199083
169regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.00181505
170regulation of membrane repolarization (GO:0060306)1.99360468
171import into cell (GO:0098657)1.98722418
172heart trabecula morphogenesis (GO:0061384)1.97536642
173glomerulus development (GO:0032835)1.97185134
174glomerular basement membrane development (GO:0032836)1.96811464
175positive regulation of potassium ion transmembrane transport (GO:1901381)1.96495512
176regulation of cell migration involved in sprouting angiogenesis (GO:0090049)1.95548387
177regulation of voltage-gated calcium channel activity (GO:1901385)1.94729755
178regulation of steroid hormone biosynthetic process (GO:0090030)1.94600891
179regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)1.94155048
180myelin maintenance (GO:0043217)1.93560568
181relaxation of cardiac muscle (GO:0055119)1.92348924
182cardiac muscle cell proliferation (GO:0060038)1.91758168
183cell communication by electrical coupling involved in cardiac conduction (GO:0086064)1.91499778
184sprouting angiogenesis (GO:0002040)1.91161551
185neuromuscular junction development (GO:0007528)1.91059489
186one-carbon compound transport (GO:0019755)1.90649151
187regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.89654290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.91683570
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.06540294
3LXR_22292898_ChIP-Seq_THP-1_Human2.84387509
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.66782518
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64469952
6* RACK7_27058665_Chip-Seq_MCF-7_Human2.58557153
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.57524400
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.51819608
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.50268732
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50176575
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48164519
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48164519
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46722158
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45946212
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43202632
16EZH2_22144423_ChIP-Seq_EOC_Human2.34277627
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.33017569
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23526371
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20382949
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15971015
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15281447
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.13346891
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.11533604
24GBX2_23144817_ChIP-Seq_PC3_Human2.05464337
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.96838922
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96637249
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95743675
28* RXR_22158963_ChIP-Seq_LIVER_Mouse1.91310196
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90663892
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.88993494
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88803836
32AR_21572438_ChIP-Seq_LNCaP_Human1.84868308
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.84198172
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83971277
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.83180403
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83009282
37* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.80565605
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79560104
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71869781
40CLOCK_20551151_ChIP-Seq_293T_Human1.66728637
41* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66522477
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65612295
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64343019
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.63676690
45* CTCF_27219007_Chip-Seq_Bcells_Human1.62937618
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62732941
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62045121
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61309978
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.61155100
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57791931
51SMC4_20622854_ChIP-Seq_HELA_Human1.57715025
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55092515
53* RUNX1_27514584_Chip-Seq_MCF-7_Human1.54746152
54* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54643747
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53853104
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.53390836
57DROSHA_22980978_ChIP-Seq_HELA_Human1.51772636
58CDX2_20551321_ChIP-Seq_CACO-2_Human1.51566037
59* CREB1_26743006_Chip-Seq_LNCaP_Human1.51378650
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.50904810
61P68_20966046_ChIP-Seq_HELA_Human1.50751944
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.50211727
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48516373
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48008436
65* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47920882
66* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46672317
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46617263
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.41047605
69TAF15_26573619_Chip-Seq_HEK293_Human1.39527423
70KDM2B_26808549_Chip-Seq_DND41_Human1.39511455
71AHR_22903824_ChIP-Seq_MCF-7_Human1.38021697
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37671470
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37655755
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37033728
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36734934
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.36122084
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35610556
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34409777
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.33899134
80* TCF7_22412390_ChIP-Seq_EML_Mouse1.32974684
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32511268
82* SA1_27219007_Chip-Seq_ERYTHROID_Human1.31780521
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30804084
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30171649
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29690594
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28828848
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28604259
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28264550
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27937790
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.26353489
91TET1_21490601_ChIP-Seq_MESCs_Mouse1.24861780
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24649682
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.24168010
94LXR_22158963_ChIP-Seq_LIVER_Mouse1.23832198
95* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22748701
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22445280
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.22358697
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22353011
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21547848
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20847100
101* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19543195
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19311757
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19311757
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.18464127
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18266696
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16938017
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16410274
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15790570
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15280105
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15105809
111HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14879107
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14085140
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13609737
114* TP63_22573176_ChIP-Seq_HFKS_Human1.12693411
115ATF3_27146783_Chip-Seq_COLON_Human1.12654416
116TP53_18474530_ChIP-ChIP_U2OS_Human1.12216267
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.12108032
118CJUN_26792858_Chip-Seq_BT549_Human1.11247056
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10628613
120SMAD3_21741376_ChIP-Seq_HESCs_Human1.10116411
121NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07562391
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06978627
123VDR_21846776_ChIP-Seq_THP-1_Human1.06620890
124SMAD4_21799915_ChIP-Seq_A2780_Human1.06408206
125SMAD4_21741376_ChIP-Seq_HESCs_Human1.06344548
126ESR1_21235772_ChIP-Seq_MCF-7_Human1.06310598
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06179849
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05939786
129* FOXA2_19822575_ChIP-Seq_HepG2_Human1.05895020
130RXR_22108803_ChIP-Seq_LS180_Human1.05806836
131STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05004834
132P300_19829295_ChIP-Seq_ESCs_Human1.04743246
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03265786
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03118836
135SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02730369
136KLF5_25053715_ChIP-Seq_YYC3_Human1.02202780
137TP53_16413492_ChIP-PET_HCT116_Human1.01973665
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01843955
139ZNF263_19887448_ChIP-Seq_K562_Human1.01225521
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01159345
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00250920
142TCF4_18268006_ChIP-ChIP_LS174T_Human0.99510380
143* RARB_24833708_ChIP-Seq_LIVER_Mouse0.98819044
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97663006
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96929189
146GATA6_25053715_ChIP-Seq_YYC3_Human0.96643101
147TP53_22127205_ChIP-Seq_IMR90_Human0.96566861
148RARB_27405468_Chip-Seq_BRAIN_Mouse0.95913958
149WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95489729
150JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95001835
151BCOR_27268052_Chip-Seq_Bcells_Human0.94955980
152TP53_20018659_ChIP-ChIP_R1E_Mouse0.94941930
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.94860287
154* SA1_27219007_Chip-Seq_Bcells_Human0.94809581
155NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94195596
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93619124
157PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93445990
158* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93234827
159CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92374881
160* SOX2_20726797_ChIP-Seq_SW620_Human0.91889816
161BCAT_22108803_ChIP-Seq_LS180_Human0.90444981
162VDR_22108803_ChIP-Seq_LS180_Human0.90080437
163* KDM2B_26808549_Chip-Seq_K562_Human0.89854856
164SMAD4_21741376_ChIP-Seq_EPCs_Human0.89222911
165RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88794958
166AR_25329375_ChIP-Seq_VCAP_Human0.88533189
167GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88371980
168ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88129266
169TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87306513
170UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87046453
171STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85716544
172SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85682571
173IGF1R_20145208_ChIP-Seq_DFB_Human0.84692111
174SOX2_21211035_ChIP-Seq_LN229_Gbm0.82002660
175MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81181050
176YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81115834
177TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80543460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.19658500
2MP0000566_synostosis4.09278145
3MP0001879_abnormal_lymphatic_vessel3.98439843
4MP0004272_abnormal_basement_membrane3.93733101
5MP0005167_abnormal_blood-brain_barrier3.47813421
6MP0003705_abnormal_hypodermis_morpholog2.95598774
7MP0005623_abnormal_meninges_morphology2.91572620
8MP0004147_increased_porphyrin_level2.74327449
9MP0005171_absent_coat_pigmentation2.60991379
10MP0010368_abnormal_lymphatic_system2.42846145
11MP0004264_abnormal_extraembryonic_tissu2.36727873
12MP0002796_impaired_skin_barrier2.33362084
13MP0003123_paternal_imprinting2.23944385
14MP0004215_abnormal_myocardial_fiber2.16513540
15MP0005670_abnormal_white_adipose2.12004570
16MP0004270_analgesia2.09787887
17MP0005058_abnormal_lysosome_morphology2.07176349
18MP0000751_myopathy2.01330336
19MP0005360_urolithiasis2.01053148
20MP0002139_abnormal_hepatobiliary_system1.99547330
21MP0004782_abnormal_surfactant_physiolog1.92233120
22MP0009379_abnormal_foot_pigmentation1.89678474
23MP0004859_abnormal_synaptic_plasticity1.88322197
24MP0000920_abnormal_myelination1.88253014
25MP0000537_abnormal_urethra_morphology1.85420846
26MP0004484_altered_response_of1.83246813
27MP0003566_abnormal_cell_adhesion1.82594072
28MP0003453_abnormal_keratinocyte_physiol1.81806606
29MP0006138_congestive_heart_failure1.80272842
30MP0003880_abnormal_central_pattern1.78573060
31MP0005076_abnormal_cell_differentiation1.77504725
32MP0005409_darkened_coat_color1.74794281
33MP0004858_abnormal_nervous_system1.74564628
34MP0009840_abnormal_foam_cell1.74480312
35MP0001968_abnormal_touch/_nociception1.73092325
36MP0001849_ear_inflammation1.72614370
37MP0003879_abnormal_hair_cell1.72563084
38MP0002089_abnormal_postnatal_growth/wei1.72389370
39MP0000678_abnormal_parathyroid_gland1.72001057
40MP0005365_abnormal_bile_salt1.68317703
41MP0003690_abnormal_glial_cell1.65255170
42MP0010030_abnormal_orbit_morphology1.64447543
43MP0003329_amyloid_beta_deposits1.64046375
44MP0002734_abnormal_mechanical_nocicepti1.57273773
45MP0001346_abnormal_lacrimal_gland1.54832834
46MP0001486_abnormal_startle_reflex1.53405461
47MP0009780_abnormal_chondrocyte_physiolo1.51094131
48MP0004084_abnormal_cardiac_muscle1.50616057
49MP0003635_abnormal_synaptic_transmissio1.50415038
50MP0000462_abnormal_digestive_system1.49567240
51MP0005666_abnormal_adipose_tissue1.46920616
52MP0001666_abnormal_nutrient_absorption1.45626022
53MP0005165_increased_susceptibility_to1.44609577
54MP0002254_reproductive_system_inflammat1.43898793
55MP0004036_abnormal_muscle_relaxation1.40576521
56MP0004019_abnormal_vitamin_homeostasis1.40509199
57MP0002736_abnormal_nociception_after1.38112474
58MP0003279_aneurysm1.37940474
59MP0003724_increased_susceptibility_to1.37808525
60MP0005375_adipose_tissue_phenotype1.37053678
61MP0008569_lethality_at_weaning1.36626408
62MP0005023_abnormal_wound_healing1.36145931
63MP0004185_abnormal_adipocyte_glucose1.35441829
64MP0005451_abnormal_body_composition1.35245496
65MP0003828_pulmonary_edema1.33310362
66MP0002127_abnormal_cardiovascular_syste1.31613921
67MP0002972_abnormal_cardiac_muscle1.31262590
68MP0010329_abnormal_lipoprotein_level1.29115273
69MP0000762_abnormal_tongue_morphology1.28981522
70MP0005595_abnormal_vascular_smooth1.28661718
71MP0002108_abnormal_muscle_morphology1.28595044
72MP0002272_abnormal_nervous_system1.27495958
73MP0005423_abnormal_somatic_nervous1.26740327
74MP0005620_abnormal_muscle_contractility1.26700993
75MP0005275_abnormal_skin_tensile1.26503736
76MP0005501_abnormal_skin_physiology1.26425647
77MP0004885_abnormal_endolymph1.25803967
78MP0005330_cardiomyopathy1.24806624
79MP0000467_abnormal_esophagus_morphology1.24053910
80MP0000013_abnormal_adipose_tissue1.23198048
81MP0003283_abnormal_digestive_organ1.23059353
82MP0000579_abnormal_nail_morphology1.22732541
83MP0003633_abnormal_nervous_system1.22028460
84MP0001958_emphysema1.20567214
85MP0001270_distended_abdomen1.20154211
86MP0002909_abnormal_adrenal_gland1.18245923
87MP0001188_hyperpigmentation1.17911585
88MP0002064_seizures1.17718543
89MP0003950_abnormal_plasma_membrane1.17707417
90MP0002295_abnormal_pulmonary_circulatio1.16804102
91MP0005084_abnormal_gallbladder_morpholo1.16739988
92MP0005257_abnormal_intraocular_pressure1.16452861
93MP0000778_abnormal_nervous_system1.14274384
94MP0004145_abnormal_muscle_electrophysio1.13813803
95MP0003045_fibrosis1.13246226
96MP0002735_abnormal_chemical_nociception1.12264246
97MP0003634_abnormal_glial_cell1.11532886
98MP0003136_yellow_coat_color1.10816496
99MP0002060_abnormal_skin_morphology1.09748837
100MP0002249_abnormal_larynx_morphology1.09101248
101MP0004085_abnormal_heartbeat1.08093459
102MP0010678_abnormal_skin_adnexa1.07563686
103MP0009745_abnormal_behavioral_response1.07287170
104MP0009046_muscle_twitch1.06327342
105MP0000749_muscle_degeneration1.03521464
106MP0002733_abnormal_thermal_nociception1.02982190
107MP0002332_abnormal_exercise_endurance0.98574185
108MP0002938_white_spotting0.98040993
109MP0001970_abnormal_pain_threshold0.97985580
110MP0001664_abnormal_digestion0.97676517
111MP0002067_abnormal_sensory_capabilities0.97133588
112MP0003191_abnormal_cellular_cholesterol0.97030154
113MP0003878_abnormal_ear_physiology0.95454221
114MP0005377_hearing/vestibular/ear_phenot0.95454221
115MP0002098_abnormal_vibrissa_morphology0.94613227
116MP0000377_abnormal_hair_follicle0.94472881
117MP0008438_abnormal_cutaneous_collagen0.93720442
118MP0002896_abnormal_bone_mineralization0.93509629
119MP0008875_abnormal_xenobiotic_pharmacok0.92498117
120MP0000383_abnormal_hair_follicle0.92063060
121MP0003631_nervous_system_phenotype0.91576328
122MP0000767_abnormal_smooth_muscle0.91098265
123MP0002063_abnormal_learning/memory/cond0.91088702
124MP0002118_abnormal_lipid_homeostasis0.90361981
125MP0005083_abnormal_biliary_tract0.89868205
126MP0000003_abnormal_adipose_tissue0.89574938
127MP0001502_abnormal_circadian_rhythm0.87271537
128MP0003075_altered_response_to0.86831348
129MP0010630_abnormal_cardiac_muscle0.86038658
130MP0000534_abnormal_ureter_morphology0.84966495
131MP0001216_abnormal_epidermal_layer0.84817119
132MP0000230_abnormal_systemic_arterial0.83728557
133MP0003942_abnormal_urinary_system0.83696415
134MP0008260_abnormal_autophagy0.83386190
135MP0005085_abnormal_gallbladder_physiolo0.81531468
136MP0006054_spinal_hemorrhage0.81340275
137MP0002837_dystrophic_cardiac_calcinosis0.80578372
138MP0010771_integument_phenotype0.80007061
139MP0002572_abnormal_emotion/affect_behav0.79954150
140MP0009384_cardiac_valve_regurgitation0.79815633
141MP0001881_abnormal_mammary_gland0.79331168
142MP0003385_abnormal_body_wall0.78959694
143MP0003172_abnormal_lysosome_physiology0.78893406
144MP0002822_catalepsy0.78612524
145MP0005385_cardiovascular_system_phenoty0.78316721
146MP0001544_abnormal_cardiovascular_syste0.78316721
147MP0001756_abnormal_urination0.77799497
148MP0002876_abnormal_thyroid_physiology0.77772028
149MP0001348_abnormal_lacrimal_gland0.77531563
150MP0001501_abnormal_sleep_pattern0.77472772
151MP0000681_abnormal_thyroid_gland0.77145539
152MP0004043_abnormal_pH_regulation0.77100646
153MP0002009_preneoplasia0.76658953
154MP0005508_abnormal_skeleton_morphology0.76032077
155MP0001905_abnormal_dopamine_level0.75366967
156MP0003115_abnormal_respiratory_system0.74788847
157MP0000627_abnormal_mammary_gland0.74575631
158MP0001440_abnormal_grooming_behavior0.74481275
159MP0003137_abnormal_impulse_conducting0.73909419
160MP0000955_abnormal_spinal_cord0.73714107
161MP0001765_abnormal_ion_homeostasis0.72241354
162MP0009250_abnormal_appendicular_skeleto0.71870163
163MP0003122_maternal_imprinting0.70865057
164MP0003300_gastrointestinal_ulcer0.70800560
165MP0010352_gastrointestinal_tract_polyps0.70722524
166MP0008775_abnormal_heart_ventricle0.70659546
167MP0009643_abnormal_urine_homeostasis0.70641221
168MP0005164_abnormal_response_to0.70619069
169MP0005503_abnormal_tendon_morphology0.70112661
170MP0009672_abnormal_birth_weight0.69085826

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)4.65061312
2Hypoplasia of the iris (HP:0007676)4.06520824
3Deep venous thrombosis (HP:0002625)3.92046714
4Segmental peripheral demyelination/remyelination (HP:0003481)3.84031987
5Onycholysis (HP:0001806)3.49281089
6Peripheral hypomyelination (HP:0007182)3.48091637
7Complement deficiency (HP:0004431)3.35155818
8Right ventricular cardiomyopathy (HP:0011663)3.30687947
9Exercise-induced muscle cramps (HP:0003710)3.13261266
10Cerebral aneurysm (HP:0004944)3.10344904
11Aplasia involving bones of the extremities (HP:0009825)3.09489065
12Aplasia involving bones of the upper limbs (HP:0009823)3.09489065
13Aplasia of the phalanges of the hand (HP:0009802)3.09489065
14Abnormality of complement system (HP:0005339)3.08389963
15Stridor (HP:0010307)3.07585731
16Lymphangioma (HP:0100764)3.06300830
17Onion bulb formation (HP:0003383)3.00232732
18Hemorrhage of the eye (HP:0011885)3.00158173
19Muscle fiber splitting (HP:0003555)2.99303333
20Broad metatarsal (HP:0001783)2.97412693
21Aplasia cutis congenita (HP:0001057)2.95518714
22Systemic lupus erythematosus (HP:0002725)2.93683009
23Hypomagnesemia (HP:0002917)2.90576285
24Short hallux (HP:0010109)2.88434919
25Shallow orbits (HP:0000586)2.87441248
26Bronchomalacia (HP:0002780)2.84819142
27Metabolic alkalosis (HP:0200114)2.83501590
28Absent hand (HP:0004050)2.80545416
29Abnormality of the axillary hair (HP:0100134)2.79573468
30Abnormality of secondary sexual hair (HP:0009888)2.79573468
31Distal upper limb amyotrophy (HP:0007149)2.76728526
32Upper limb amyotrophy (HP:0009129)2.76728526
33Hemiparesis (HP:0001269)2.75633137
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.70615496
35Hyperacusis (HP:0010780)2.70220843
36Increased circulating renin level (HP:0000848)2.64454220
37Atrophic scars (HP:0001075)2.59742350
38Myokymia (HP:0002411)2.57597425
39Action tremor (HP:0002345)2.57313258
40Hyporeflexia of lower limbs (HP:0002600)2.55980604
41Aplasia/Hypoplasia of the hallux (HP:0008362)2.55191919
42Glomerulonephritis (HP:0000099)2.51914773
43Steppage gait (HP:0003376)2.51434534
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.50514801
45Distal lower limb amyotrophy (HP:0008944)2.50310478
46Axonal loss (HP:0003447)2.49761503
47Cerebral inclusion bodies (HP:0100314)2.49453153
48Advanced eruption of teeth (HP:0006288)2.49447061
49Broad face (HP:0000283)2.49136260
50Insidious onset (HP:0003587)2.48253634
51Termporal pattern (HP:0011008)2.48253634
52Sudden death (HP:0001699)2.47256968
53Abnormality of the Achilles tendon (HP:0005109)2.46453712
54Protrusio acetabuli (HP:0003179)2.45291227
55Acanthosis nigricans (HP:0000956)2.43920120
56Flat acetabular roof (HP:0003180)2.42608303
57Xanthomatosis (HP:0000991)2.38155229
58Abnormality of binocular vision (HP:0011514)2.38032150
59Diplopia (HP:0000651)2.38032150
60Premature rupture of membranes (HP:0001788)2.37688429
61Milia (HP:0001056)2.37409569
62Cervical subluxation (HP:0003308)2.37139098
63J-shaped sella turcica (HP:0002680)2.36751744
64Muscle stiffness (HP:0003552)2.35806824
65Prolonged QT interval (HP:0001657)2.34151636
66Polydipsia (HP:0001959)2.33392059
67Abnormal drinking behavior (HP:0030082)2.33392059
68Adactyly (HP:0009776)2.32708052
69Turricephaly (HP:0000262)2.32238140
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.31177550
71Calf muscle hypertrophy (HP:0008981)2.30868275
72Hemiplegia (HP:0002301)2.30275880
73Abnormality of magnesium homeostasis (HP:0004921)2.29258314
74Abnormality of the calf musculature (HP:0001430)2.28671756
75Megalencephaly (HP:0001355)2.28551998
76Achilles tendon contracture (HP:0001771)2.27505917
77Atrial fibrillation (HP:0005110)2.26022044
78Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.24132550
79Muscle hypertrophy of the lower extremities (HP:0008968)2.22454231
80Foot dorsiflexor weakness (HP:0009027)2.21127803
81Exercise-induced myalgia (HP:0003738)2.21014831
82Confusion (HP:0001289)2.17229278
83Hypokalemic alkalosis (HP:0001949)2.16795903
84Distal lower limb muscle weakness (HP:0009053)2.15417398
85Potter facies (HP:0002009)2.15114078
86Facial shape deformation (HP:0011334)2.15114078
87Ulnar bowing (HP:0003031)2.13730932
88Humeroradial synostosis (HP:0003041)2.13172800
89Synostosis involving the elbow (HP:0003938)2.13172800
90Mildly elevated creatine phosphokinase (HP:0008180)2.11846409
91Fragile nails (HP:0001808)2.10525592
92Ventricular tachycardia (HP:0004756)2.10094627
93Focal segmental glomerulosclerosis (HP:0000097)2.07219199
94Increased CSF protein (HP:0002922)2.06887085
95Neurofibrillary tangles (HP:0002185)2.05704183
96Supraventricular arrhythmia (HP:0005115)2.05615816
97Thin bony cortex (HP:0002753)2.05482656
98Primary atrial arrhythmia (HP:0001692)2.04572522
99Growth hormone excess (HP:0000845)2.03852632
100Pili torti (HP:0003777)2.03609046
101Follicular hyperkeratosis (HP:0007502)2.02483904
102Abnormal urine output (HP:0012590)2.00464279
103Polyuria (HP:0000103)1.99465218
104Hyperventilation (HP:0002883)1.99324470
105Vascular calcification (HP:0004934)1.99101144
106Vascular tortuosity (HP:0004948)1.98677898
107Arterial tortuosity (HP:0005116)1.98338646
108Focal motor seizures (HP:0011153)1.97347699
109Difficulty running (HP:0009046)1.97337028
110Exotropia (HP:0000577)1.96871593
111Absent eyebrow (HP:0002223)1.96581330
112Amelogenesis imperfecta (HP:0000705)1.96514585
113Abnormality of the foot musculature (HP:0001436)1.95800088
114Visceral angiomatosis (HP:0100761)1.95729237
115Nephritis (HP:0000123)1.95548043
116Atonic seizures (HP:0010819)1.95081074
117Overgrowth (HP:0001548)1.94965220
118Lower limb amyotrophy (HP:0007210)1.94659463
119Abnormality of the middle phalanges of the toes (HP:0010183)1.94348284
120Nuclear cataract (HP:0100018)1.93106587
121Germ cell neoplasia (HP:0100728)1.92515906
122Gout (HP:0001997)1.92267698
123Abnormality of renal excretion (HP:0011036)1.90765843
124White forelock (HP:0002211)1.89135404
125Hammertoe (HP:0001765)1.88732436
126Glomerulosclerosis (HP:0000096)1.88650108
127Pancreatic islet-cell hyperplasia (HP:0004510)1.88639117
128Neonatal death (HP:0003811)1.88565199
129Increased variability in muscle fiber diameter (HP:0003557)1.88341625
130Ankle clonus (HP:0011448)1.88234728
131Interstitial pulmonary disease (HP:0006530)1.87962909
132Asymmetry of the thorax (HP:0001555)1.87781000
133Supraventricular tachycardia (HP:0004755)1.87035989
134Thickened helices (HP:0000391)1.86747377
135Abnormality of the distal phalanges of the toes (HP:0010182)1.85660758
136Joint hemorrhage (HP:0005261)1.85000948
137Ventricular fibrillation (HP:0001663)1.84210869
138Bulbar palsy (HP:0001283)1.84031832
139Abnormality of carpal bone ossification (HP:0006257)1.83910471
140Impaired proprioception (HP:0010831)1.83382457
141Hemangiomatosis (HP:0007461)1.82972514
142Abnormality of calcium-phosphate metabolism (HP:0100530)1.82845125
143Hyperinsulinemic hypoglycemia (HP:0000825)1.82685780
144Increased connective tissue (HP:0009025)1.81488865
145Syncope (HP:0001279)1.81058094
146Late onset (HP:0003584)1.80293358
147Hand muscle atrophy (HP:0009130)1.80158479
148Polar cataract (HP:0010696)1.79550879
149Hypoglycemic seizures (HP:0002173)1.79013529
150Buphthalmos (HP:0000557)1.78820593
151Prolonged partial thromboplastin time (HP:0003645)1.78577562
152Partial duplication of thumb phalanx (HP:0009944)1.78296430
153Amblyopia (HP:0000646)1.78291605
154Choanal stenosis (HP:0000452)1.77318540
155Supranuclear gaze palsy (HP:0000605)1.77167105
156Fragile skin (HP:0001030)1.76726221
157Hyperthyroidism (HP:0000836)1.75197773
158Obstructive sleep apnea (HP:0002870)1.74818467
159Myotonia (HP:0002486)1.74789105
160Esophageal atresia (HP:0002032)1.74391069
161Aneurysm (HP:0002617)1.73921042
162Bifid scrotum (HP:0000048)1.73884903
163Hypotrichosis (HP:0001006)1.73097168
164Pulmonary artery stenosis (HP:0004415)1.72683932
165Paraparesis (HP:0002385)1.72678019
166Pterygium (HP:0001059)1.72559315
167Abnormality of permanent molar morphology (HP:0011071)1.71572538
168Abnormality of the dental root (HP:0006486)1.71572538
169Taurodontia (HP:0000679)1.71572538
170Cardiovascular calcification (HP:0011915)1.71144435
171Hypercholesterolemia (HP:0003124)1.70682553
172Hyperparathyroidism (HP:0000843)1.69759665
173Akinesia (HP:0002304)1.69259470
174Abnormality of molar morphology (HP:0011070)1.69209392
175Abnormality of molar (HP:0011077)1.69209392
176Alacrima (HP:0000522)1.68441059
177Abnormal hair laboratory examination (HP:0003328)1.67913293
178Spinal cord compression (HP:0002176)1.67287416
179Abdominal distention (HP:0003270)1.63741595
180Congenital glaucoma (HP:0001087)1.63402988
181Malnutrition (HP:0004395)1.62786081
182Blue sclerae (HP:0000592)1.60614377
183Short nail (HP:0001799)1.59262154
184Alopecia of scalp (HP:0002293)1.58739153
185Abnormal ossification of hand bones (HP:0005921)1.57883893
186Intrahepatic cholestasis (HP:0001406)1.56959862
187Mucopolysacchariduria (HP:0008155)1.55946146
188Urinary glycosaminoglycan excretion (HP:0003541)1.55946146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.35245926
2TRIB35.20143995
3KDR4.77174856
4TIE14.41403597
5SIK14.34297263
6MST1R3.43454163
7STK392.61750988
8FGFR42.56975919
9EPHB22.51503635
10ERN12.51091317
11SMG12.32533174
12ICK2.18143272
13OXSR12.17093504
14WNK41.90330491
15CAMK1G1.89021683
16PTK2B1.84460564
17PKN21.84407963
18IRAK31.78229181
19NUAK11.76467265
20EEF2K1.75887602
21DMPK1.74853288
22PNCK1.72986227
23LMTK21.71121010
24MYLK1.67711590
25TESK11.67524885
26PHKG11.67490635
27PHKG21.67490635
28FGFR21.65839308
29LATS21.62841183
30GRK11.58666487
31EPHA41.57579005
32EPHB11.56177086
33PDGFRA1.54251317
34INSRR1.51465498
35WNK11.50024724
36PDK21.45130514
37MAPK151.41912515
38AKT31.37575142
39FER1.30733312
40PAK41.30221860
41NTRK21.27952640
42CASK1.26866893
43BCR1.26216157
44TGFBR21.22352725
45DDR21.19054588
46MAP3K21.18712509
47MAP2K21.14850715
48BMPR1B1.14676888
49TNIK1.11702929
50SGK2231.10508830
51SGK4941.10508830
52RIPK11.07025115
53NTRK31.06485610
54MARK21.06278666
55PRKCE1.05382677
56NEK61.03683709
57BMX1.01987627
58PAK31.01874381
59ROCK10.99125195
60MAPKAPK30.98180687
61TAOK10.95650093
62MTOR0.94952303
63MAPK120.94827367
64MAP3K60.94088343
65PRKG20.92962908
66NTRK10.92285403
67ILK0.91847203
68PTK60.91353592
69PRKD30.91108193
70DAPK20.90530024
71PRKD10.90037400
72PAK60.89557525
73PRKD20.89527157
74ROCK20.88438610
75PRPF4B0.86465088
76FRK0.84362643
77MUSK0.83513024
78TYRO30.82844127
79LATS10.81360383
80GRK50.81205637
81MAP3K110.80990416
82PRKCI0.80863112
83RPS6KA20.80035213
84PRKAA20.79836244
85MAP3K90.79064332
86NME10.76829395
87MAP2K10.76595674
88CDK120.76430663
89MINK10.75470663
90TNK20.74693486
91PDPK10.74387739
92ARAF0.73498306
93WNK30.73361535
94CDK50.73142019
95FGFR30.72421024
96STK380.72387123
97CAMK2A0.71419764
98NLK0.70590353
99PINK10.70257682
100MAP3K30.69870981
101CAMK1D0.69129925
102MAP2K60.69096443
103IRAK20.67711510
104MAPKAPK50.65269543
105TTN0.64603698
106MAPK70.64419422
107PRKCH0.63926730
108ERBB20.62594135
109PKN10.61602856
110CAMK2D0.60868158
111HIPK20.60027849
112PIK3CA0.60011665
113CAMK10.59587599
114PTK20.58905237
115KSR20.58746727
116NME20.57818983
117CAMK2B0.57818965
118STK110.56412842
119UHMK10.56125418
120RPS6KB20.54706289
121MATK0.52892245
122RET0.52827862
123CAMK2G0.52393697
124SGK20.52075160
125FGR0.51678758
126PDGFRB0.51210559
127GSK3A0.50582828
128DAPK30.49108507
129EPHA30.48973015
130MET0.48878131
131FES0.48724531
132OBSCN0.47741397
133CDC42BPA0.47452663
134MAP3K70.47085906
135MAPK130.47044018
136PLK20.44904157
137CAMK40.44634702
138LIMK10.44516605
139IGF1R0.43443935
140SRC0.43426374
141MARK10.43369328
142INSR0.43322562
143PAK20.42688525
144MAP3K10.41462602
145MAP3K40.38527437
146CAMKK10.36892582
147LRRK20.35364202
148FGFR10.33762518
149RPS6KC10.33613023
150RPS6KL10.33613023
151ABL20.32055432
152PRKCZ0.29817111

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.17374415
2Histidine metabolism_Homo sapiens_hsa003402.79515055
3Arginine biosynthesis_Homo sapiens_hsa002202.25100391
4Phenylalanine metabolism_Homo sapiens_hsa003602.08226367
5Complement and coagulation cascades_Homo sapiens_hsa046102.04269623
6Arginine and proline metabolism_Homo sapiens_hsa003301.68911326
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67611502
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67213723
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.63473757
10Dilated cardiomyopathy_Homo sapiens_hsa054141.62469150
11ECM-receptor interaction_Homo sapiens_hsa045121.62127253
12Other glycan degradation_Homo sapiens_hsa005111.59729024
13Glutamatergic synapse_Homo sapiens_hsa047241.58212816
14GABAergic synapse_Homo sapiens_hsa047271.57968801
15Gastric acid secretion_Homo sapiens_hsa049711.56963498
16Salivary secretion_Homo sapiens_hsa049701.51344263
17Axon guidance_Homo sapiens_hsa043601.51342194
18Circadian entrainment_Homo sapiens_hsa047131.50477154
19Prion diseases_Homo sapiens_hsa050201.48064763
20Vitamin B6 metabolism_Homo sapiens_hsa007501.45346934
21Fructose and mannose metabolism_Homo sapiens_hsa000511.45298506
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45167837
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43868253
24Mineral absorption_Homo sapiens_hsa049781.43796709
25Protein digestion and absorption_Homo sapiens_hsa049741.43495893
26Dorso-ventral axis formation_Homo sapiens_hsa043201.42001852
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.38205750
28Focal adhesion_Homo sapiens_hsa045101.37575056
29Cardiac muscle contraction_Homo sapiens_hsa042601.37416749
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36118109
31Tight junction_Homo sapiens_hsa045301.35871203
32PPAR signaling pathway_Homo sapiens_hsa033201.34328230
33Adherens junction_Homo sapiens_hsa045201.33831769
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33045191
35Morphine addiction_Homo sapiens_hsa050321.32235285
36Cholinergic synapse_Homo sapiens_hsa047251.27570686
37Insulin secretion_Homo sapiens_hsa049111.27475777
38Bile secretion_Homo sapiens_hsa049761.24721590
39Tyrosine metabolism_Homo sapiens_hsa003501.24496059
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24463482
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23807957
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23428858
43Sulfur relay system_Homo sapiens_hsa041221.22786693
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22386091
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20699681
46Rap1 signaling pathway_Homo sapiens_hsa040151.20575761
47beta-Alanine metabolism_Homo sapiens_hsa004101.19615503
48Nitrogen metabolism_Homo sapiens_hsa009101.16931538
49Serotonergic synapse_Homo sapiens_hsa047261.16004430
50Galactose metabolism_Homo sapiens_hsa000521.15784479
51Melanogenesis_Homo sapiens_hsa049161.13977941
52Renin secretion_Homo sapiens_hsa049241.13912355
53Nicotine addiction_Homo sapiens_hsa050331.10766662
54Long-term depression_Homo sapiens_hsa047301.10712953
55Vibrio cholerae infection_Homo sapiens_hsa051101.10597849
56cAMP signaling pathway_Homo sapiens_hsa040241.10031437
57Fat digestion and absorption_Homo sapiens_hsa049751.08360804
58Ras signaling pathway_Homo sapiens_hsa040141.07684549
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.07164739
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06349321
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05935095
62Gap junction_Homo sapiens_hsa045401.05646416
63Oxytocin signaling pathway_Homo sapiens_hsa049211.05156151
64AMPK signaling pathway_Homo sapiens_hsa041521.03624961
65Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02061062
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01081231
67ABC transporters_Homo sapiens_hsa020101.01019809
68Taste transduction_Homo sapiens_hsa047420.99989861
69Dopaminergic synapse_Homo sapiens_hsa047280.99053022
70Insulin signaling pathway_Homo sapiens_hsa049100.99020908
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.97750872
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97610108
73Amphetamine addiction_Homo sapiens_hsa050310.97071549
74Calcium signaling pathway_Homo sapiens_hsa040200.96482795
75Long-term potentiation_Homo sapiens_hsa047200.94209509
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92638353
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.92417810
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92108081
79Olfactory transduction_Homo sapiens_hsa047400.92023005
80Fatty acid metabolism_Homo sapiens_hsa012120.91700478
81Hedgehog signaling pathway_Homo sapiens_hsa043400.91241307
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.89610706
83Renal cell carcinoma_Homo sapiens_hsa052110.89598108
84Pancreatic secretion_Homo sapiens_hsa049720.89071531
85Fatty acid degradation_Homo sapiens_hsa000710.88922816
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88915793
87Biosynthesis of amino acids_Homo sapiens_hsa012300.88889778
88Cocaine addiction_Homo sapiens_hsa050300.85835238
89African trypanosomiasis_Homo sapiens_hsa051430.83827180
90Ovarian steroidogenesis_Homo sapiens_hsa049130.83761562
91Glucagon signaling pathway_Homo sapiens_hsa049220.83461975
92Sphingolipid metabolism_Homo sapiens_hsa006000.83447966
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83083553
94GnRH signaling pathway_Homo sapiens_hsa049120.82247526
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81692788
96Insulin resistance_Homo sapiens_hsa049310.81122116
97Synaptic vesicle cycle_Homo sapiens_hsa047210.81078914
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.80169674
99Basal cell carcinoma_Homo sapiens_hsa052170.77783333
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77717039
101Hippo signaling pathway_Homo sapiens_hsa043900.77379718
102Estrogen signaling pathway_Homo sapiens_hsa049150.77356833
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75458286
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75214915
105Folate biosynthesis_Homo sapiens_hsa007900.74629010
106Amoebiasis_Homo sapiens_hsa051460.73732704
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73588874
108Fatty acid elongation_Homo sapiens_hsa000620.73329374
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73211579
110Vitamin digestion and absorption_Homo sapiens_hsa049770.73071206
111Choline metabolism in cancer_Homo sapiens_hsa052310.72017815
112Proteoglycans in cancer_Homo sapiens_hsa052050.71627143
113Starch and sucrose metabolism_Homo sapiens_hsa005000.69831802
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69481797
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68866574
116Rheumatoid arthritis_Homo sapiens_hsa053230.67525034
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.66785415
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66143426
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.66093915
120Retinol metabolism_Homo sapiens_hsa008300.65715672
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65568702
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65273617
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64967749
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63392606
125Wnt signaling pathway_Homo sapiens_hsa043100.62241016
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.61892835
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.61795944
128Notch signaling pathway_Homo sapiens_hsa043300.61778060
129Alzheimers disease_Homo sapiens_hsa050100.61635948
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61585907
131Ether lipid metabolism_Homo sapiens_hsa005650.61516940
132Pentose phosphate pathway_Homo sapiens_hsa000300.60449150
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59900353
134VEGF signaling pathway_Homo sapiens_hsa043700.59601302
135Thyroid hormone synthesis_Homo sapiens_hsa049180.59577702
136Pathways in cancer_Homo sapiens_hsa052000.59567529
137Glioma_Homo sapiens_hsa052140.59295475
138Renin-angiotensin system_Homo sapiens_hsa046140.59280086
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.56345942
140Endocytosis_Homo sapiens_hsa041440.56282978
141TGF-beta signaling pathway_Homo sapiens_hsa043500.56109314
142Fatty acid biosynthesis_Homo sapiens_hsa000610.55483956
143N-Glycan biosynthesis_Homo sapiens_hsa005100.55386717
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55163868
145Collecting duct acid secretion_Homo sapiens_hsa049660.54738726
146MAPK signaling pathway_Homo sapiens_hsa040100.54710051
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54016895
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54015804
149Arachidonic acid metabolism_Homo sapiens_hsa005900.53554683
150Chemical carcinogenesis_Homo sapiens_hsa052040.53435335
151ErbB signaling pathway_Homo sapiens_hsa040120.53166994
152Melanoma_Homo sapiens_hsa052180.53120005
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53059136
154Lysine degradation_Homo sapiens_hsa003100.52801509
155Bladder cancer_Homo sapiens_hsa052190.52685283
156Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52120721
157Lysosome_Homo sapiens_hsa041420.50548629
158Endometrial cancer_Homo sapiens_hsa052130.47296665

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »