VWA5B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)6.19336383
2cilium or flagellum-dependent cell motility (GO:0001539)6.16455636
3axonemal dynein complex assembly (GO:0070286)5.63748980
4epithelial cilium movement (GO:0003351)5.62274352
5behavioral response to nicotine (GO:0035095)5.57501043
6acrosome reaction (GO:0007340)5.54332420
7fucose catabolic process (GO:0019317)4.96534593
8L-fucose metabolic process (GO:0042354)4.96534593
9L-fucose catabolic process (GO:0042355)4.96534593
10motile cilium assembly (GO:0044458)4.71725306
11ventricular system development (GO:0021591)4.67837584
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.64843250
13sperm motility (GO:0030317)4.47095428
14neuron cell-cell adhesion (GO:0007158)4.45078502
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.08266576
16startle response (GO:0001964)4.06273338
17platelet dense granule organization (GO:0060155)3.99807238
18vocalization behavior (GO:0071625)3.89711105
19regulation of cilium movement (GO:0003352)3.88945069
20calcium ion-dependent exocytosis (GO:0017156)3.87733618
21DNA deamination (GO:0045006)3.87004661
22tryptophan catabolic process (GO:0006569)3.82642084
23indole-containing compound catabolic process (GO:0042436)3.82642084
24indolalkylamine catabolic process (GO:0046218)3.82642084
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.74050680
26axoneme assembly (GO:0035082)3.71383989
27regulation of synaptic vesicle exocytosis (GO:2000300)3.67042012
28righting reflex (GO:0060013)3.66004109
29presynaptic membrane assembly (GO:0097105)3.65455681
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.64850042
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.62749071
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.62027393
33kynurenine metabolic process (GO:0070189)3.60136884
34protein polyglutamylation (GO:0018095)3.51833977
35cellular ketone body metabolic process (GO:0046950)3.50081599
36indolalkylamine metabolic process (GO:0006586)3.44607035
37postsynaptic membrane organization (GO:0001941)3.42952798
38regulation of glutamate receptor signaling pathway (GO:1900449)3.42518530
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.39569623
40response to auditory stimulus (GO:0010996)3.38253490
41protein localization to synapse (GO:0035418)3.34378637
42regulation of synaptic vesicle transport (GO:1902803)3.31768096
43glutamate receptor signaling pathway (GO:0007215)3.30625641
44protein localization to cilium (GO:0061512)3.30613836
45acrosome assembly (GO:0001675)3.28648876
46intraciliary transport (GO:0042073)3.28640136
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28544676
48presynaptic membrane organization (GO:0097090)3.28164054
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.28090620
50gamma-aminobutyric acid transport (GO:0015812)3.26874710
51multicellular organism reproduction (GO:0032504)3.26790764
52fusion of sperm to egg plasma membrane (GO:0007342)3.26204326
53left/right axis specification (GO:0070986)3.23054297
54water-soluble vitamin biosynthetic process (GO:0042364)3.21702104
55negative regulation of telomere maintenance (GO:0032205)3.21564565
56detection of light stimulus involved in sensory perception (GO:0050962)3.21389890
57detection of light stimulus involved in visual perception (GO:0050908)3.21389890
58tryptophan metabolic process (GO:0006568)3.20562242
59neuromuscular process controlling posture (GO:0050884)3.20310778
60transmission of nerve impulse (GO:0019226)3.19815552
61cilium assembly (GO:0042384)3.18141234
62cilium organization (GO:0044782)3.17720353
63positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.17580123
64retinal cone cell development (GO:0046549)3.16927210
65ketone body metabolic process (GO:1902224)3.15142844
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11115762
67auditory behavior (GO:0031223)3.10877652
68synaptic vesicle exocytosis (GO:0016079)3.10536880
69synaptic transmission, glutamatergic (GO:0035249)3.10396200
70negative regulation of mast cell activation (GO:0033004)3.09673338
71piRNA metabolic process (GO:0034587)3.09293891
72reciprocal meiotic recombination (GO:0007131)3.09026072
73reciprocal DNA recombination (GO:0035825)3.09026072
74nephron epithelium morphogenesis (GO:0072088)3.07908079
75nephron tubule morphogenesis (GO:0072078)3.07908079
76neuronal action potential propagation (GO:0019227)3.06617775
77cell wall macromolecule catabolic process (GO:0016998)3.03734599
78cell wall macromolecule metabolic process (GO:0044036)3.03734599
79neurotransmitter uptake (GO:0001504)3.03673227
80neurotransmitter transport (GO:0006836)3.03063540
81nonmotile primary cilium assembly (GO:0035058)3.01897431
82protein complex biogenesis (GO:0070271)3.01215066
83proline transport (GO:0015824)3.01101975
84neural tube formation (GO:0001841)3.01086881
85neuronal action potential (GO:0019228)2.99838773
86neuron recognition (GO:0008038)2.98629127
87neurotransmitter secretion (GO:0007269)2.97758610
88neuron-neuron synaptic transmission (GO:0007270)2.97703994
89behavioral response to ethanol (GO:0048149)2.97622308
90spermatid development (GO:0007286)2.96666406
91protein K11-linked deubiquitination (GO:0035871)2.96317896
92photoreceptor cell maintenance (GO:0045494)2.95296682
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94952864
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.94952864
95NADH dehydrogenase complex assembly (GO:0010257)2.94952864
96locomotory exploration behavior (GO:0035641)2.93113466
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90789141
98regulation of action potential (GO:0098900)2.90731135
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89927323
100regulation of microtubule-based movement (GO:0060632)2.88184717
101calcium ion import (GO:0070509)2.87023498
102photoreceptor cell development (GO:0042461)2.85750087
103protein-cofactor linkage (GO:0018065)2.85669478
104regulation of glucokinase activity (GO:0033131)2.82054217
105regulation of hexokinase activity (GO:1903299)2.82054217
106plasma membrane fusion (GO:0045026)2.81878274
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81459499
108synaptic vesicle maturation (GO:0016188)2.80117700
109cerebellar Purkinje cell differentiation (GO:0021702)2.79406834
110cellular biogenic amine catabolic process (GO:0042402)2.78986562
111amine catabolic process (GO:0009310)2.78986562
112response to pheromone (GO:0019236)2.77539419
113membrane depolarization during action potential (GO:0086010)2.76942767
114negative regulation of neurotransmitter transport (GO:0051589)2.76203737
115mitochondrial respiratory chain complex assembly (GO:0033108)2.74352719
116pyrimidine nucleobase catabolic process (GO:0006208)2.73662757
117glutamate secretion (GO:0014047)2.73290718
118sperm capacitation (GO:0048240)2.73029011
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72147965
120left/right pattern formation (GO:0060972)2.71518996
121long-term memory (GO:0007616)2.71341645
122preassembly of GPI anchor in ER membrane (GO:0016254)2.71314257
123axonal fasciculation (GO:0007413)2.70484825
124regulation of respiratory gaseous exchange (GO:0043576)2.70216923
125regulation of respiratory system process (GO:0044065)2.69273795
126glycine transport (GO:0015816)2.68725258
127indole-containing compound metabolic process (GO:0042430)2.67759130
128synaptic transmission, cholinergic (GO:0007271)2.67310096
129cornea development in camera-type eye (GO:0061303)2.67290251
130neurotransmitter catabolic process (GO:0042135)2.66806666
131reflex (GO:0060004)2.65896120
132long-chain fatty acid biosynthetic process (GO:0042759)2.65648493
133mechanosensory behavior (GO:0007638)2.64979779
134protein K6-linked ubiquitination (GO:0085020)2.64891197
135cilium morphogenesis (GO:0060271)2.64830070
136negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64820687
137L-amino acid import (GO:0043092)2.63728170
138eye photoreceptor cell development (GO:0042462)2.63289339
139regulation of neurotransmitter secretion (GO:0046928)2.62947050
140positive regulation of synapse assembly (GO:0051965)2.60935730
141glycerophospholipid catabolic process (GO:0046475)2.60837935
142nucleoside diphosphate phosphorylation (GO:0006165)2.60477166
143reproduction (GO:0000003)2.60420985
144serotonin receptor signaling pathway (GO:0007210)2.59814838
145synaptic vesicle endocytosis (GO:0048488)2.58989333
146regulation of synaptic transmission, GABAergic (GO:0032228)2.57571690
147regulation of telomere maintenance (GO:0032204)2.57486967
148exploration behavior (GO:0035640)2.57464095
149cellular component assembly involved in morphogenesis (GO:0010927)2.57237926
150mating behavior (GO:0007617)2.57179145
151positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.57098371
152positive regulation of meiosis (GO:0045836)2.56768656
153regulation of synaptic transmission, glutamatergic (GO:0051966)2.56142691
154retina layer formation (GO:0010842)2.54577206
155S-adenosylmethionine metabolic process (GO:0046500)2.53884493
156sperm-egg recognition (GO:0035036)2.53819850
157regulation of neuronal synaptic plasticity (GO:0048168)2.53496343
158rhodopsin mediated signaling pathway (GO:0016056)2.53121846
159kidney morphogenesis (GO:0060993)2.53053012
160regulation of neurotransmitter uptake (GO:0051580)2.52072616
161opioid receptor signaling pathway (GO:0038003)2.51702943
162fucosylation (GO:0036065)2.51411486
163centriole replication (GO:0007099)2.51163268
164DNA methylation involved in gamete generation (GO:0043046)2.50081318
165regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49657293
166somite development (GO:0061053)2.49271082
167aromatic amino acid family catabolic process (GO:0009074)2.49211310
168regulation of meiosis I (GO:0060631)2.48959372
169negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48828079
170alanine transport (GO:0032328)2.48315942
171sulfation (GO:0051923)2.47817670
172male meiosis I (GO:0007141)2.47707687
173detection of mechanical stimulus involved in sensory perception (GO:0050974)2.46703268
174respiratory chain complex IV assembly (GO:0008535)2.45721356
175mannosylation (GO:0097502)2.45386068
176L-methionine salvage (GO:0071267)2.44850067
177L-methionine biosynthetic process (GO:0071265)2.44850067
178amino acid salvage (GO:0043102)2.44850067
179exogenous drug catabolic process (GO:0042738)2.44010951
180auditory receptor cell stereocilium organization (GO:0060088)2.43786356
181inositol phosphate catabolic process (GO:0071545)2.42650894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39353600
2GBX2_23144817_ChIP-Seq_PC3_Human3.45020939
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65293744
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38097073
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35121151
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32279964
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27777200
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.18132355
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.16750262
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14914092
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13157391
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.11767822
13TAF15_26573619_Chip-Seq_HEK293_Human2.07167940
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06500973
15EWS_26573619_Chip-Seq_HEK293_Human2.01912207
16* CBX2_27304074_Chip-Seq_ESCs_Mouse2.00783487
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99768292
18VDR_22108803_ChIP-Seq_LS180_Human1.98852656
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97200586
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96939587
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96684964
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95304933
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93731814
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93731814
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90593257
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89253170
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88453519
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86135327
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.85443337
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79728446
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75759047
32SMAD4_21799915_ChIP-Seq_A2780_Human1.75303195
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.74777425
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.74206005
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73589135
36IGF1R_20145208_ChIP-Seq_DFB_Human1.72864490
37RNF2_27304074_Chip-Seq_NSC_Mouse1.72142494
38P300_19829295_ChIP-Seq_ESCs_Human1.70812688
39DROSHA_22980978_ChIP-Seq_HELA_Human1.65604110
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65043902
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64222476
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.63757867
43IRF1_19129219_ChIP-ChIP_H3396_Human1.63032377
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.61122882
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60987273
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57517787
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57098797
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56522622
49TP53_22573176_ChIP-Seq_HFKS_Human1.56478702
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.56031861
51BCAT_22108803_ChIP-Seq_LS180_Human1.54425676
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54157190
53CBP_20019798_ChIP-Seq_JUKART_Human1.54157190
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54048886
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53937615
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.51722906
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46921774
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42281633
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42147759
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41774156
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40972666
62ER_23166858_ChIP-Seq_MCF-7_Human1.40819436
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40225610
64FUS_26573619_Chip-Seq_HEK293_Human1.39874856
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.39756203
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.39198931
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.39072291
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38750030
69P53_22387025_ChIP-Seq_ESCs_Mouse1.37528030
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36654833
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36224467
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.36027979
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36027979
74* SMAD3_21741376_ChIP-Seq_EPCs_Human1.34853701
75SOX2_19829295_ChIP-Seq_ESCs_Human1.33865690
76NANOG_19829295_ChIP-Seq_ESCs_Human1.33865690
77AR_21572438_ChIP-Seq_LNCaP_Human1.32813107
78ZNF274_21170338_ChIP-Seq_K562_Hela1.32361554
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.31966644
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31813595
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.30401658
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.30221642
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29782195
84* TCF4_22108803_ChIP-Seq_LS180_Human1.29080238
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28044967
86* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27645166
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27322759
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26872528
89STAT3_23295773_ChIP-Seq_U87_Human1.26530890
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25915538
91AR_25329375_ChIP-Seq_VCAP_Human1.25501875
92MYC_18940864_ChIP-ChIP_HL60_Human1.25292627
93P300_18555785_Chip-Seq_ESCs_Mouse1.24132386
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23289559
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23157986
96NCOR_22424771_ChIP-Seq_293T_Human1.23028771
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.21327461
98* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21281692
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.19680914
100* TCF4_23295773_ChIP-Seq_U87_Human1.18685132
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18580309
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18455354
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.18263508
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18070880
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18043290
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.17952524
107AR_20517297_ChIP-Seq_VCAP_Human1.17919476
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17868980
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17868980
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17328063
111GABP_17652178_ChIP-ChIP_JURKAT_Human1.16876452
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16659768
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.16529531
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16365469
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14141764
116RUNX2_22187159_ChIP-Seq_PCA_Human1.13597699
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.13381536
118* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13250233
119RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13226583
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12109536
121* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11734748
122HOXB7_26014856_ChIP-Seq_BT474_Human1.10720008
123KLF4_18555785_Chip-Seq_ESCs_Mouse1.09752252
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09648701
125PU1_27457419_Chip-Seq_LIVER_Mouse1.09098804
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09080406
127ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08757402
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08298793
129KDM2B_26808549_Chip-Seq_REH_Human1.07018230
130ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06237864
131ZFX_18555785_Chip-Seq_ESCs_Mouse1.06159829
132EST1_17652178_ChIP-ChIP_JURKAT_Human1.06046756
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05522955
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.05094900
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.05086460
136PRDM14_20953172_ChIP-Seq_ESCs_Human1.03922059
137MYC_19829295_ChIP-Seq_ESCs_Human1.03085055
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02528691
139AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01407898
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99747779
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97372759
142CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95363124
143KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93867266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.89837086
2MP0005410_abnormal_fertilization3.54490419
3MP0005646_abnormal_pituitary_gland3.15559796
4MP0005645_abnormal_hypothalamus_physiol3.12173430
5MP0003787_abnormal_imprinting3.02901156
6MP0009046_muscle_twitch3.01345177
7MP0004859_abnormal_synaptic_plasticity2.96769960
8MP0003195_calcinosis2.81590377
9MP0003122_maternal_imprinting2.70677010
10MP0005423_abnormal_somatic_nervous2.70651783
11MP0003635_abnormal_synaptic_transmissio2.64549864
12MP0006276_abnormal_autonomic_nervous2.57739334
13MP0009745_abnormal_behavioral_response2.57711378
14MP0001968_abnormal_touch/_nociception2.52330979
15MP0001501_abnormal_sleep_pattern2.52027534
16MP0002837_dystrophic_cardiac_calcinosis2.47600475
17MP0002064_seizures2.42924292
18MP0001486_abnormal_startle_reflex2.37152096
19MP0002572_abnormal_emotion/affect_behav2.26241011
20MP0001188_hyperpigmentation2.22765943
21MP0003011_delayed_dark_adaptation2.20874171
22MP0002063_abnormal_learning/memory/cond2.13460354
23MP0002272_abnormal_nervous_system2.13306477
24MP0002102_abnormal_ear_morphology2.11269811
25MP0003136_yellow_coat_color2.09852984
26MP0002736_abnormal_nociception_after2.05792433
27MP0002638_abnormal_pupillary_reflex2.00724222
28MP0002876_abnormal_thyroid_physiology1.96338589
29MP0008877_abnormal_DNA_methylation1.95759731
30MP0000372_irregular_coat_pigmentation1.92179119
31MP0002734_abnormal_mechanical_nocicepti1.82781093
32MP0002557_abnormal_social/conspecific_i1.81327894
33MP0006292_abnormal_olfactory_placode1.80746324
34MP0001502_abnormal_circadian_rhythm1.80097774
35MP0001440_abnormal_grooming_behavior1.78333952
36MP0008872_abnormal_physiological_respon1.77530894
37MP0002067_abnormal_sensory_capabilities1.77138507
38MP0005084_abnormal_gallbladder_morpholo1.76021576
39MP0003646_muscle_fatigue1.75876853
40MP0001984_abnormal_olfaction1.74514831
41MP0000427_abnormal_hair_cycle1.68887207
42MP0002735_abnormal_chemical_nociception1.67561579
43MP0003121_genomic_imprinting1.67196942
44MP0008875_abnormal_xenobiotic_pharmacok1.66073834
45MP0004043_abnormal_pH_regulation1.65021425
46MP0005379_endocrine/exocrine_gland_phen1.61296878
47MP0004742_abnormal_vestibular_system1.59934608
48MP0002938_white_spotting1.59683412
49MP0004270_analgesia1.58846554
50MP0004142_abnormal_muscle_tone1.57799730
51MP0004147_increased_porphyrin_level1.57424889
52MP0003698_abnormal_male_reproductive1.55535898
53MP0002733_abnormal_thermal_nociception1.51428550
54MP0005171_absent_coat_pigmentation1.49147441
55MP0005551_abnormal_eye_electrophysiolog1.47661637
56MP0002163_abnormal_gland_morphology1.42463277
57MP0000631_abnormal_neuroendocrine_gland1.40944934
58MP0002184_abnormal_innervation1.39563053
59MP0001970_abnormal_pain_threshold1.39406160
60MP0000778_abnormal_nervous_system1.36495140
61MP0001905_abnormal_dopamine_level1.32504909
62MP0005409_darkened_coat_color1.31443736
63MP0005389_reproductive_system_phenotype1.24875364
64MP0005174_abnormal_tail_pigmentation1.24250612
65MP0002138_abnormal_hepatobiliary_system1.21583153
66MP0005253_abnormal_eye_physiology1.21488582
67MP0005386_behavior/neurological_phenoty1.20864485
68MP0004924_abnormal_behavior1.20864485
69MP0001963_abnormal_hearing_physiology1.20315869
70MP0005195_abnormal_posterior_eye1.19782279
71MP0002160_abnormal_reproductive_system1.19350432
72MP0001986_abnormal_taste_sensitivity1.19204987
73MP0000026_abnormal_inner_ear1.17031931
74MP0003123_paternal_imprinting1.16321837
75MP0002234_abnormal_pharynx_morphology1.15965996
76MP0002653_abnormal_ependyma_morphology1.14891153
77MP0010386_abnormal_urinary_bladder1.11755146
78MP0002928_abnormal_bile_duct1.11668596
79MP0001529_abnormal_vocalization1.10224565
80MP0003690_abnormal_glial_cell1.09582216
81MP0000015_abnormal_ear_pigmentation1.08308198
82MP0001919_abnormal_reproductive_system1.07879581
83MP0003879_abnormal_hair_cell1.07289511
84MP0002882_abnormal_neuron_morphology1.06924237
85MP0008004_abnormal_stomach_pH1.06214028
86MP0003283_abnormal_digestive_organ1.05889007
87MP0006072_abnormal_retinal_apoptosis1.05245121
88MP0002066_abnormal_motor_capabilities/c1.04149973
89MP0003718_maternal_effect1.02816892
90MP0001929_abnormal_gametogenesis1.02713458
91MP0005167_abnormal_blood-brain_barrier1.01665431
92MP0002095_abnormal_skin_pigmentation1.01301277
93MP0008569_lethality_at_weaning1.00446542
94MP0005075_abnormal_melanosome_morpholog0.95492605
95MP0008775_abnormal_heart_ventricle0.93169934
96MP0000955_abnormal_spinal_cord0.93071405
97MP0000230_abnormal_systemic_arterial0.92706285
98MP0003878_abnormal_ear_physiology0.90451422
99MP0005377_hearing/vestibular/ear_phenot0.90451422
100MP0003633_abnormal_nervous_system0.90391526
101MP0004811_abnormal_neuron_physiology0.89385970
102MP0002229_neurodegeneration0.88456804
103MP0001324_abnormal_eye_pigmentation0.85739763
104MP0002751_abnormal_autonomic_nervous0.84984403
105MP0002752_abnormal_somatic_nervous0.84866795
106MP0002277_abnormal_respiratory_mucosa0.84540670
107MP0001485_abnormal_pinna_reflex0.83878902
108MP0005085_abnormal_gallbladder_physiolo0.83108070
109MP0009780_abnormal_chondrocyte_physiolo0.82230892
110MP0002152_abnormal_brain_morphology0.81615477
111MP0003252_abnormal_bile_duct0.78825932
112MP0002282_abnormal_trachea_morphology0.77443833
113MP0001764_abnormal_homeostasis0.75640320
114MP0002161_abnormal_fertility/fecundity0.74712565
115MP0003631_nervous_system_phenotype0.74688179
116MP0005535_abnormal_body_temperature0.74592849
117MP0004885_abnormal_endolymph0.74226531
118MP0003938_abnormal_ear_development0.73596234
119MP0000383_abnormal_hair_follicle0.73118700
120MP0005623_abnormal_meninges_morphology0.71774200
121MP0001664_abnormal_digestion0.69983218
122MP0001346_abnormal_lacrimal_gland0.67885656
123MP0002069_abnormal_eating/drinking_beha0.67260934
124MP0000569_abnormal_digit_pigmentation0.67023635
125MP0004133_heterotaxia0.66491143
126MP0002909_abnormal_adrenal_gland0.66092487
127MP0002210_abnormal_sex_determination0.65676300
128MP0000681_abnormal_thyroid_gland0.64004218
129MP0003634_abnormal_glial_cell0.62601490
130MP0005670_abnormal_white_adipose0.62586510
131MP0005394_taste/olfaction_phenotype0.60914873
132MP0005499_abnormal_olfactory_system0.60914873
133MP0000920_abnormal_myelination0.58715627
134MP0004145_abnormal_muscle_electrophysio0.58159235
135MP0003183_abnormal_peptide_metabolism0.57160038

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.01655381
2Absent/shortened dynein arms (HP:0200106)7.42036412
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.42036412
4Abnormal respiratory motile cilium physiology (HP:0012261)6.91616270
5Abnormal ciliary motility (HP:0012262)6.85042392
6Abnormal respiratory epithelium morphology (HP:0012253)6.24164149
7Abnormal respiratory motile cilium morphology (HP:0005938)6.24164149
8Rhinitis (HP:0012384)5.33254897
9Focal motor seizures (HP:0011153)4.58980232
10Congenital stationary night blindness (HP:0007642)4.11351931
11Type II lissencephaly (HP:0007260)3.87256882
12Nephronophthisis (HP:0000090)3.56662154
13Febrile seizures (HP:0002373)3.36785629
14Abnormality of the renal cortex (HP:0011035)3.34604855
15Abolished electroretinogram (ERG) (HP:0000550)3.25021669
16Cerebellar dysplasia (HP:0007033)3.24631718
17Chronic bronchitis (HP:0004469)3.19151628
18Attenuation of retinal blood vessels (HP:0007843)3.13187486
19Tubular atrophy (HP:0000092)3.11997324
20Medial flaring of the eyebrow (HP:0010747)3.09263086
21Epileptic encephalopathy (HP:0200134)3.05987606
22Molar tooth sign on MRI (HP:0002419)3.03558405
23Abnormality of midbrain morphology (HP:0002418)3.03558405
24Cystic liver disease (HP:0006706)2.96411214
25Decreased electroretinogram (ERG) amplitude (HP:0000654)2.94603940
26Chronic hepatic failure (HP:0100626)2.94367215
27Focal seizures (HP:0007359)2.90870564
28Gait imbalance (HP:0002141)2.84430304
29Abnormal rod and cone electroretinograms (HP:0008323)2.80676806
30Abnormality of the renal medulla (HP:0100957)2.77482578
31Congenital primary aphakia (HP:0007707)2.73569459
32Tubulointerstitial nephritis (HP:0001970)2.72598141
33Pancreatic fibrosis (HP:0100732)2.71063226
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70574005
35Abnormality of alanine metabolism (HP:0010916)2.70574005
36Hyperalaninemia (HP:0003348)2.70574005
37Bronchiectasis (HP:0002110)2.70225797
38Progressive cerebellar ataxia (HP:0002073)2.68085033
39Infertility (HP:0000789)2.63591161
40Abnormal hair whorl (HP:0010721)2.63353362
41True hermaphroditism (HP:0010459)2.61088708
42Abnormality of the pons (HP:0007361)2.60506826
43Sclerocornea (HP:0000647)2.60194116
44Lissencephaly (HP:0001339)2.58143326
45Nephrogenic diabetes insipidus (HP:0009806)2.56374252
46Hypoplasia of the pons (HP:0012110)2.55560070
47Pendular nystagmus (HP:0012043)2.47190190
48Increased corneal curvature (HP:0100692)2.47189234
49Keratoconus (HP:0000563)2.47189234
50Visual hallucinations (HP:0002367)2.47140802
51Abnormality of molar (HP:0011077)2.37598251
52Abnormality of molar morphology (HP:0011070)2.37598251
53Abnormality of the dental root (HP:0006486)2.36716893
54Taurodontia (HP:0000679)2.36716893
55Abnormality of permanent molar morphology (HP:0011071)2.36716893
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34657997
57Anencephaly (HP:0002323)2.33137076
58Atonic seizures (HP:0010819)2.32472793
59Polyuria (HP:0000103)2.31131436
60Abnormality of the dental pulp (HP:0006479)2.28708475
61Renal cortical cysts (HP:0000803)2.28239348
62Hemiparesis (HP:0001269)2.25905209
63Aplasia/Hypoplasia of the lens (HP:0008063)2.25819566
64Decreased central vision (HP:0007663)2.24374008
65Genital tract atresia (HP:0001827)2.21580259
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.20521122
67Generalized tonic-clonic seizures (HP:0002069)2.20171426
68Median cleft lip (HP:0000161)2.19649586
69Congenital, generalized hypertrichosis (HP:0004540)2.19280431
70Furrowed tongue (HP:0000221)2.18384770
71Severe muscular hypotonia (HP:0006829)2.17689173
72Pachygyria (HP:0001302)2.15208538
73Vaginal atresia (HP:0000148)2.14257931
74Polyphagia (HP:0002591)2.14238722
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13760593
76Bony spicule pigmentary retinopathy (HP:0007737)2.10486961
77Abnormal biliary tract physiology (HP:0012439)2.07884432
78Bile duct proliferation (HP:0001408)2.07884432
79Hyperventilation (HP:0002883)2.07350420
80Absence seizures (HP:0002121)2.05120019
81Hyperphosphatemia (HP:0002905)2.05040050
82Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04648978
83Abnormal drinking behavior (HP:0030082)2.03950903
84Polydipsia (HP:0001959)2.03950903
85Dialeptic seizures (HP:0011146)2.02674835
863-Methylglutaconic aciduria (HP:0003535)2.02492693
87Poor coordination (HP:0002370)2.02096793
88Large for gestational age (HP:0001520)2.01726719
89Abnormality of incisor morphology (HP:0011063)1.96627787
90Acute necrotizing encephalopathy (HP:0006965)1.95919552
91Menstrual irregularities (HP:0000858)1.95756442
92Optic disc pallor (HP:0000543)1.95653057
93Broad-based gait (HP:0002136)1.94110184
94Fetal akinesia sequence (HP:0001989)1.92781752
95Concave nail (HP:0001598)1.91111144
96Postaxial foot polydactyly (HP:0001830)1.90861345
97Congenital sensorineural hearing impairment (HP:0008527)1.90767285
98Bilateral microphthalmos (HP:0007633)1.89871841
99Septo-optic dysplasia (HP:0100842)1.89749796
100Occipital encephalocele (HP:0002085)1.88087579
101Aplasia/Hypoplasia of the tibia (HP:0005772)1.87007160
102Atelectasis (HP:0100750)1.86498708
103Abnormality of calcium-phosphate metabolism (HP:0100530)1.86199633
104Congenital hepatic fibrosis (HP:0002612)1.85965048
105Progressive macrocephaly (HP:0004481)1.83003757
106Abnormal urine output (HP:0012590)1.82771014
107Decreased circulating renin level (HP:0003351)1.81531966
108Acute encephalopathy (HP:0006846)1.80819034
109Mitochondrial inheritance (HP:0001427)1.80675553
110Pancreatic cysts (HP:0001737)1.79511905
111Increased CSF lactate (HP:0002490)1.79316707
112Methylmalonic acidemia (HP:0002912)1.77830167
113Absent speech (HP:0001344)1.77302605
114Recurrent sinusitis (HP:0011108)1.77014318
115Retinal dysplasia (HP:0007973)1.76360777
116Abnormality of the labia minora (HP:0012880)1.75550346
117Tubulointerstitial fibrosis (HP:0005576)1.75411124
118Optic nerve hypoplasia (HP:0000609)1.75051090
119Blue irides (HP:0000635)1.75015790
120Abnormality of renal resorption (HP:0011038)1.74856485
121Hypothermia (HP:0002045)1.74826004
122Hyperglycinuria (HP:0003108)1.74154212
123Agitation (HP:0000713)1.73901268
124Gaze-evoked nystagmus (HP:0000640)1.73540137
125Tachypnea (HP:0002789)1.72737727
126Retinitis pigmentosa (HP:0000510)1.72420334
127Specific learning disability (HP:0001328)1.70728392
128Widely spaced teeth (HP:0000687)1.70024046
129Preaxial hand polydactyly (HP:0001177)1.69991595
130Stage 5 chronic kidney disease (HP:0003774)1.69671666
131Protruding tongue (HP:0010808)1.69352776
132Abnormal eating behavior (HP:0100738)1.68583797
133Aplasia involving bones of the extremities (HP:0009825)1.68183948
134Aplasia involving bones of the upper limbs (HP:0009823)1.68183948
135Aplasia of the phalanges of the hand (HP:0009802)1.68183948
136Postaxial hand polydactyly (HP:0001162)1.66883733
137Abnormality of the fovea (HP:0000493)1.64018741
138Generalized hypopigmentation of hair (HP:0011358)1.63352120
139Progressive inability to walk (HP:0002505)1.63089848
140Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62512156
141Fair hair (HP:0002286)1.62475514
142Failure to thrive in infancy (HP:0001531)1.57011723
143Aganglionic megacolon (HP:0002251)1.56270744
144White forelock (HP:0002211)1.56193307
145Abnormality of renal excretion (HP:0011036)1.54149612
146Supranuclear gaze palsy (HP:0000605)1.53441268
147Chronic sinusitis (HP:0011109)1.51954266
148Myokymia (HP:0002411)1.51284616
149Nephropathy (HP:0000112)1.50942652
150Tubulointerstitial abnormality (HP:0001969)1.50655856
151Absent septum pellucidum (HP:0001331)1.50375417
152Peripheral hypomyelination (HP:0007182)1.49777859
153Inability to walk (HP:0002540)1.49359850
154Male pseudohermaphroditism (HP:0000037)1.49107055
155Aplasia/Hypoplasia of the fovea (HP:0008060)1.49031370
156Hypoplasia of the fovea (HP:0007750)1.49031370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.05466088
2NTRK34.48425743
3CASK3.80743181
4MAP2K73.23680238
5MAP4K23.08552656
6PNCK2.72044656
7TNIK2.70772571
8NTRK22.66542501
9MAP3K42.50507015
10NUAK12.30181877
11ACVR1B2.20938033
12MAPK152.15814410
13PRKD32.05643458
14TLK12.01146408
15MARK11.98579829
16EPHA41.88291139
17INSRR1.76157442
18MAP3K121.75012174
19TAOK31.62556267
20RIPK41.61218864
21MAPK131.56953130
22SIK31.55806764
23ADRBK21.53036593
24MUSK1.49490050
25NEK61.48316716
26GRK71.41457697
27PRPF4B1.41110101
28TNK21.39579753
29TIE11.37153506
30TRIM281.36555625
31MINK11.33181338
32DYRK21.30533488
33BMPR21.26666704
34PAK61.21786216
35MAP2K41.19699134
36STK391.15922637
37PLK21.14861548
38CDK31.13763871
39MKNK21.12474691
40UHMK11.11006337
41GRK11.09921262
42BLK1.08609524
43PRKCG1.07947969
44SGK21.06966837
45FES1.06687473
46STK381.06302200
47CAMK2A1.05904711
48BCKDK1.05704405
49PDK31.05594234
50PDK41.05594234
51PKN11.05208211
52AKT31.04556266
53GRK51.03655560
54YES11.02707124
55SIK21.02217205
56BCR1.02164485
57MARK31.00267783
58PIK3CA0.99995965
59CCNB10.99929300
60MAP3K90.99719118
61MAPKAPK30.99624576
62PINK10.92741689
63SGK2230.91467516
64SGK4940.91467516
65PTK2B0.90792462
66CAMK1G0.89540663
67OXSR10.88584798
68IRAK20.86642385
69TESK10.86368575
70PDK20.85911848
71WNK30.85458296
72CAMKK20.84583378
73PLK40.84316563
74ICK0.82544095
75PRKCE0.81613517
76WNK40.79842454
77TGFBR10.79561403
78STK38L0.77838483
79CDK50.76408587
80BMPR1B0.75850380
81TXK0.73218560
82STK160.72555618
83CAMK10.70551047
84IRAK10.70453603
85CSNK1G20.70224470
86PHKG20.69887422
87PHKG10.69887422
88FGFR20.69578428
89CDC42BPA0.68935431
90WNK10.67036646
91DAPK20.64748223
92PRKCH0.64026746
93MAP3K130.60547229
94PRKG10.60261334
95NME10.58877158
96BRSK20.58598401
97PRKCI0.58351548
98CSNK1G30.57392253
99CSNK1G10.57353240
100IKBKB0.56233157
101DYRK1A0.55776833
102EPHA30.55157310
103RPS6KA50.54660499
104SGK10.54305123
105ZAK0.53197627
106MST40.52854068
107SGK30.52717774
108NTRK10.52674370
109WEE10.52602735
110PLK30.51786782
111STK30.51330568
112CAMKK10.50891912
113EIF2AK20.49675533
114ERBB30.49386091
115TEC0.49065976
116KIT0.48618199
117CAMK2B0.48304520
118PRKACA0.47809597
119NLK0.47339237
120MAPKAPK50.47090010
121CAMK2D0.46711147
122IRAK40.46074383
123VRK20.46044285
124MAP2K60.45900804
125IRAK30.45452957
126RPS6KB10.45262635
127STK110.45198757
128PRKCZ0.44449234
129MAP3K140.44330141
130CAMK2G0.44169575
131TAF10.42147489
132VRK10.42025277
133CDK190.41608721
134FER0.41493821
135PAK30.40467529
136PDK10.40376998
137EIF2AK30.36923191
138PRKCA0.36310625
139CSNK1A10.36214700
140NEK20.35688270
141PRKAA20.34096673
142PIK3CG0.33985515
143ADRBK10.33908834
144BRAF0.33493865
145PRKCQ0.33193687
146PRKAA10.32685110
147CSNK1A1L0.31779539
148CSNK1D0.30216439
149IGF1R0.30190699
150DYRK30.29554345
151CHUK0.29508143

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.37467037
2Synaptic vesicle cycle_Homo sapiens_hsa047212.98430025
3GABAergic synapse_Homo sapiens_hsa047272.87588616
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76112153
5Morphine addiction_Homo sapiens_hsa050322.65180192
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57140067
7Taste transduction_Homo sapiens_hsa047422.46720206
8Butanoate metabolism_Homo sapiens_hsa006502.39348767
9Nitrogen metabolism_Homo sapiens_hsa009102.37030589
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.34415911
11Circadian entrainment_Homo sapiens_hsa047132.33112410
12Serotonergic synapse_Homo sapiens_hsa047262.31366892
13Selenocompound metabolism_Homo sapiens_hsa004502.29664608
14Insulin secretion_Homo sapiens_hsa049112.20250250
15Glutamatergic synapse_Homo sapiens_hsa047242.17616032
16Amphetamine addiction_Homo sapiens_hsa050312.16416427
17Collecting duct acid secretion_Homo sapiens_hsa049662.08233979
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07256550
19Olfactory transduction_Homo sapiens_hsa047402.05808170
20Caffeine metabolism_Homo sapiens_hsa002322.01859590
21Protein export_Homo sapiens_hsa030601.86111466
22Cocaine addiction_Homo sapiens_hsa050301.86082673
23Tryptophan metabolism_Homo sapiens_hsa003801.83423497
24Salivary secretion_Homo sapiens_hsa049701.76952365
25Homologous recombination_Homo sapiens_hsa034401.76563781
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61174715
27Parkinsons disease_Homo sapiens_hsa050121.59949458
28Propanoate metabolism_Homo sapiens_hsa006401.57824133
29Dopaminergic synapse_Homo sapiens_hsa047281.53895263
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53529420
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52541937
32Basal transcription factors_Homo sapiens_hsa030221.51190423
33Calcium signaling pathway_Homo sapiens_hsa040201.50263900
34Type I diabetes mellitus_Homo sapiens_hsa049401.49941068
35Phototransduction_Homo sapiens_hsa047441.49417952
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48135594
37RNA polymerase_Homo sapiens_hsa030201.42709847
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39202561
39Long-term potentiation_Homo sapiens_hsa047201.38178244
40Renin secretion_Homo sapiens_hsa049241.34698471
41Gastric acid secretion_Homo sapiens_hsa049711.29944054
42Long-term depression_Homo sapiens_hsa047301.28265613
43Cholinergic synapse_Homo sapiens_hsa047251.26045214
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.24036076
45Peroxisome_Homo sapiens_hsa041461.23552575
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23022468
47Rheumatoid arthritis_Homo sapiens_hsa053231.21303570
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20546466
49Vibrio cholerae infection_Homo sapiens_hsa051101.19225480
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18048477
51RNA degradation_Homo sapiens_hsa030181.17019640
52Autoimmune thyroid disease_Homo sapiens_hsa053201.15961991
53cAMP signaling pathway_Homo sapiens_hsa040241.14715344
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13915088
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12091516
56Type II diabetes mellitus_Homo sapiens_hsa049301.08331127
57Ovarian steroidogenesis_Homo sapiens_hsa049131.08323177
58Chemical carcinogenesis_Homo sapiens_hsa052041.07675620
59Ether lipid metabolism_Homo sapiens_hsa005651.07367517
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.06894586
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.05769038
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04978780
63ABC transporters_Homo sapiens_hsa020101.04007513
64Retinol metabolism_Homo sapiens_hsa008301.00758391
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00261860
66Oxytocin signaling pathway_Homo sapiens_hsa049210.95231416
67Axon guidance_Homo sapiens_hsa043600.94811941
68One carbon pool by folate_Homo sapiens_hsa006700.94520637
69Fatty acid biosynthesis_Homo sapiens_hsa000610.92406295
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88861285
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87748120
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87019377
73Mineral absorption_Homo sapiens_hsa049780.86855119
74GnRH signaling pathway_Homo sapiens_hsa049120.86807854
75Cardiac muscle contraction_Homo sapiens_hsa042600.86274639
76Graft-versus-host disease_Homo sapiens_hsa053320.86185661
77Dorso-ventral axis formation_Homo sapiens_hsa043200.86075660
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83161195
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82970026
80Estrogen signaling pathway_Homo sapiens_hsa049150.81252328
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80605029
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80076067
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79834946
84Melanogenesis_Homo sapiens_hsa049160.77810851
85Primary immunodeficiency_Homo sapiens_hsa053400.76024405
86Glycerolipid metabolism_Homo sapiens_hsa005610.75670390
87Oxidative phosphorylation_Homo sapiens_hsa001900.75020713
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.74961748
89Sphingolipid metabolism_Homo sapiens_hsa006000.74890985
90Histidine metabolism_Homo sapiens_hsa003400.74017096
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73675419
92Vitamin B6 metabolism_Homo sapiens_hsa007500.73355231
93Huntingtons disease_Homo sapiens_hsa050160.72253588
94beta-Alanine metabolism_Homo sapiens_hsa004100.72069338
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71458103
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70435099
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69822843
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69069828
99Hedgehog signaling pathway_Homo sapiens_hsa043400.67876071
100Thyroid hormone synthesis_Homo sapiens_hsa049180.66500748
101Linoleic acid metabolism_Homo sapiens_hsa005910.66274425
102Pancreatic secretion_Homo sapiens_hsa049720.66111985
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65551115
104Fat digestion and absorption_Homo sapiens_hsa049750.65104317
105MAPK signaling pathway_Homo sapiens_hsa040100.64931618
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62996264
107Allograft rejection_Homo sapiens_hsa053300.62673285
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62365986
109Arachidonic acid metabolism_Homo sapiens_hsa005900.61627509
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60990203
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.60901181
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.59979671
113Metabolic pathways_Homo sapiens_hsa011000.59803872
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59530601
115Asthma_Homo sapiens_hsa053100.59376559
116Fatty acid degradation_Homo sapiens_hsa000710.59176991
117Gap junction_Homo sapiens_hsa045400.57554167
118Wnt signaling pathway_Homo sapiens_hsa043100.56578623
119Circadian rhythm_Homo sapiens_hsa047100.56538341
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56515962
121Inositol phosphate metabolism_Homo sapiens_hsa005620.55999077
122Phagosome_Homo sapiens_hsa041450.55729713
123Steroid biosynthesis_Homo sapiens_hsa001000.55589150
124Ras signaling pathway_Homo sapiens_hsa040140.53264081
125Sulfur metabolism_Homo sapiens_hsa009200.52831877
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.51438257
127African trypanosomiasis_Homo sapiens_hsa051430.51237383
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51106694
129Non-homologous end-joining_Homo sapiens_hsa034500.49192638
130Fanconi anemia pathway_Homo sapiens_hsa034600.49033984
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48469212
132Regulation of autophagy_Homo sapiens_hsa041400.46675151
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46008828
134Glucagon signaling pathway_Homo sapiens_hsa049220.45135777
135Proteasome_Homo sapiens_hsa030500.45071528
136ErbB signaling pathway_Homo sapiens_hsa040120.44006085
137Fatty acid metabolism_Homo sapiens_hsa012120.43949180
138Fatty acid elongation_Homo sapiens_hsa000620.43560881
139Alzheimers disease_Homo sapiens_hsa050100.42242090
140Dilated cardiomyopathy_Homo sapiens_hsa054140.41985002
141Prion diseases_Homo sapiens_hsa050200.41838773
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39668541
143Alcoholism_Homo sapiens_hsa050340.38746161
144Sulfur relay system_Homo sapiens_hsa041220.37576938
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36678476
146Choline metabolism in cancer_Homo sapiens_hsa052310.36423370
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.35457770
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34728767
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30182020
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28507286
151Purine metabolism_Homo sapiens_hsa002300.26979679
152Maturity onset diabetes of the young_Homo sapiens_hsa049500.26045337

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