VWA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.48587234
2neurofilament cytoskeleton organization (GO:0060052)9.22322458
3cilium or flagellum-dependent cell motility (GO:0001539)8.72961663
4cilium movement (GO:0003341)7.89088031
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.87648192
6epithelial cilium movement (GO:0003351)7.54778204
7axoneme assembly (GO:0035082)6.70864184
8motile cilium assembly (GO:0044458)6.53776225
9negative regulation of dendrite morphogenesis (GO:0050774)6.49061920
10peripheral nervous system neuron development (GO:0048935)6.45794063
11detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.77678532
12detection of temperature stimulus involved in sensory perception (GO:0050961)5.77678532
13detection of temperature stimulus (GO:0016048)5.77336417
14regulation of relaxation of muscle (GO:1901077)5.39480178
15negative regulation of calcium ion transport into cytosol (GO:0010523)5.30167944
16neuronal action potential propagation (GO:0019227)5.22161516
17negative regulation of homotypic cell-cell adhesion (GO:0034111)4.76046562
18regulation of cilium movement (GO:0003352)4.75451143
19protein localization to cilium (GO:0061512)4.67866916
20regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.55756474
21cell migration in hindbrain (GO:0021535)4.54026589
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.53869105
23intermediate filament organization (GO:0045109)4.53277887
24calcium-mediated signaling using intracellular calcium source (GO:0035584)4.52160255
25regulation of cell communication by electrical coupling (GO:0010649)4.44261058
26regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.43329733
27regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.41144102
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.38011810
29plasma membrane repair (GO:0001778)4.30331476
30cilium organization (GO:0044782)4.26615885
31left/right axis specification (GO:0070986)4.22205033
32negative regulation of dendrite development (GO:2000171)4.20560546
33cilium assembly (GO:0042384)4.13515707
34intraciliary transport (GO:0042073)4.11544746
35negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.11387971
36cellular ketone body metabolic process (GO:0046950)4.07336704
37membrane depolarization during action potential (GO:0086010)4.06571149
38sarcoplasmic reticulum calcium ion transport (GO:0070296)4.05759943
39neuronal action potential (GO:0019228)4.01427019
40regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.00465380
41regulation of platelet aggregation (GO:0090330)3.92923488
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87345825
43ketone body metabolic process (GO:1902224)3.75926565
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.73560570
45cell communication involved in cardiac conduction (GO:0086065)3.73494912
46regulation of glucokinase activity (GO:0033131)3.71366429
47regulation of hexokinase activity (GO:1903299)3.71366429
48microtubule bundle formation (GO:0001578)3.69545978
49regulation of membrane repolarization (GO:0060306)3.67454828
50cilium morphogenesis (GO:0060271)3.64682605
51left/right pattern formation (GO:0060972)3.58287510
52primary alcohol catabolic process (GO:0034310)3.46406462
53cellular component assembly involved in morphogenesis (GO:0010927)3.41187805
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.39612197
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37057841
56neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.35296743
57L-fucose metabolic process (GO:0042354)3.35037246
58L-fucose catabolic process (GO:0042355)3.35037246
59fucose catabolic process (GO:0019317)3.35037246
60mitochondrion transport along microtubule (GO:0047497)3.32514330
61establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.32514330
62negative regulation of striated muscle cell apoptotic process (GO:0010664)3.29288647
63pyrimidine ribonucleoside catabolic process (GO:0046133)3.26364766
64ventricular system development (GO:0021591)3.23942297
65positive regulation of potassium ion transmembrane transport (GO:1901381)3.20740263
66establishment of mitochondrion localization (GO:0051654)3.19887861
67negative regulation of cardiac muscle hypertrophy (GO:0010614)3.19246773
68cornea development in camera-type eye (GO:0061303)3.18240443
69regulation of actin filament-based movement (GO:1903115)3.18190819
70negative regulation of cAMP-mediated signaling (GO:0043951)3.16844065
71one-carbon compound transport (GO:0019755)3.14101526
72regulation of calcium ion transmembrane transporter activity (GO:1901019)3.13129421
73regulation of calcium ion transmembrane transport (GO:1903169)3.13129421
74photoreceptor cell maintenance (GO:0045494)3.12260007
75inositol phosphate catabolic process (GO:0071545)3.11163131
76negative regulation of muscle hypertrophy (GO:0014741)3.10779907
77sarcomere organization (GO:0045214)3.10272691
78axon development (GO:0061564)3.09872790
79negative regulation of potassium ion transmembrane transport (GO:1901380)3.09299735
80vitamin transmembrane transport (GO:0035461)3.09191883
81serotonin receptor signaling pathway (GO:0007210)3.09075926
82retinal cone cell development (GO:0046549)3.06238232
83positive regulation of cAMP-mediated signaling (GO:0043950)3.04291765
84regulation of cardiac muscle contraction (GO:0055117)3.04282844
85detection of light stimulus involved in sensory perception (GO:0050962)3.03645910
86detection of light stimulus involved in visual perception (GO:0050908)3.03645910
87terpenoid biosynthetic process (GO:0016114)3.02652234
88response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.02185575
89behavioral response to pain (GO:0048266)3.02160487
90ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.01567017
91cell communication by electrical coupling (GO:0010644)2.99410291
92heart contraction (GO:0060047)2.98479724
93heart process (GO:0003015)2.98479724
94intermediate filament-based process (GO:0045103)2.98359737
95cardiac muscle contraction (GO:0060048)2.97965551
96action potential (GO:0001508)2.97790232
97nucleoside diphosphate phosphorylation (GO:0006165)2.96542989
98response to acidic pH (GO:0010447)2.96424705
99aldehyde catabolic process (GO:0046185)2.96360246
100regulation of striated muscle contraction (GO:0006942)2.95978183
101neuron fate specification (GO:0048665)2.94851924
102detection of mechanical stimulus involved in sensory perception (GO:0050974)2.94552672
103regulation of microtubule-based movement (GO:0060632)2.94283146
104respiratory chain complex IV assembly (GO:0008535)2.92497019
105intermediate filament cytoskeleton organization (GO:0045104)2.91942147
106regulation of heart rate by cardiac conduction (GO:0086091)2.90404568
107water-soluble vitamin biosynthetic process (GO:0042364)2.89499709
108response to xenobiotic stimulus (GO:0009410)2.89498037
109ethanol metabolic process (GO:0006067)2.88295765
110cerebellar Purkinje cell differentiation (GO:0021702)2.88201465
111ventricular trabecula myocardium morphogenesis (GO:0003222)2.85704661
112diterpenoid biosynthetic process (GO:0016102)2.85280563
113lung epithelium development (GO:0060428)2.85207321
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83153581
115bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83144763
116myofibril assembly (GO:0030239)2.83002278
117response to pheromone (GO:0019236)2.81391656
118nucleotide transmembrane transport (GO:1901679)2.81324356
119cellular response to nicotine (GO:0071316)2.81019134
120neural tube formation (GO:0001841)2.79376498
121pyrimidine-containing compound transmembrane transport (GO:0072531)2.79336853
122organic cation transport (GO:0015695)2.79174770
123phosphorylated carbohydrate dephosphorylation (GO:0046838)2.78783515
124inositol phosphate dephosphorylation (GO:0046855)2.78783515
125exogenous drug catabolic process (GO:0042738)2.78076615
126cranial nerve development (GO:0021545)2.77189886
127cardiac conduction (GO:0061337)2.75246677
128cytidine metabolic process (GO:0046087)2.74920355
129cytidine catabolic process (GO:0006216)2.74920355
130cytidine deamination (GO:0009972)2.74920355
131striated muscle contraction (GO:0006941)2.74436507
132cardiac muscle tissue morphogenesis (GO:0055008)2.74039724
133regulation of cardiac muscle cell contraction (GO:0086004)2.73791919
134cell projection assembly (GO:0030031)2.73445159
135negative regulation of platelet activation (GO:0010544)2.70996357
136glutathione derivative metabolic process (GO:1901685)2.70418511
137glutathione derivative biosynthetic process (GO:1901687)2.70418511
138regulation of protein heterodimerization activity (GO:0043497)2.69673669
139nonmotile primary cilium assembly (GO:0035058)2.67445583
140cardiac muscle cell action potential involved in contraction (GO:0086002)2.67313317
141retinoic acid metabolic process (GO:0042573)2.67140332
142L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67117921
143mechanoreceptor differentiation (GO:0042490)2.66873315
144negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66519626
145phosphatidylethanolamine biosynthetic process (GO:0006646)2.65655617
146phosphatidylethanolamine metabolic process (GO:0046337)2.65407723
147positive regulation of macrophage differentiation (GO:0045651)2.65376656
148isoprenoid biosynthetic process (GO:0008299)2.65011939
149neuromuscular process controlling posture (GO:0050884)2.63885643
150negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.63539206
151S-adenosylmethionine metabolic process (GO:0046500)2.63186852
152mannosylation (GO:0097502)2.63140921
153positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.61841657
154sperm motility (GO:0030317)2.61538343
155regulation of NFAT protein import into nucleus (GO:0051532)2.61356631
156positive regulation of potassium ion transport (GO:0043268)2.60847869
157membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.60576815
158ubiquinone biosynthetic process (GO:0006744)2.60443114
159cardiac muscle cell action potential (GO:0086001)2.58734236
160negative regulation of T cell differentiation in thymus (GO:0033085)2.58465155
161negative regulation of cation channel activity (GO:2001258)2.58463749
162regulation of neuron projection regeneration (GO:0070570)2.58414489
163regulation of axon regeneration (GO:0048679)2.58414489
164regulation of cation channel activity (GO:2001257)2.57543070
165regulation of cell maturation (GO:1903429)2.56926560
166centriole assembly (GO:0098534)2.56847377
167polyol catabolic process (GO:0046174)2.56111225
168positive regulation of sodium ion transport (GO:0010765)2.55789514
169preassembly of GPI anchor in ER membrane (GO:0016254)2.54580491
170auditory receptor cell stereocilium organization (GO:0060088)2.53651133
171platelet dense granule organization (GO:0060155)2.53624171
172negative regulation of B cell mediated immunity (GO:0002713)2.52860010
173negative regulation of immunoglobulin mediated immune response (GO:0002890)2.52860010
174behavioral response to nicotine (GO:0035095)2.50807389
175proline transport (GO:0015824)2.49821578
176sialylation (GO:0097503)2.49654415
177glycosphingolipid biosynthetic process (GO:0006688)2.49607853
178ubiquinone metabolic process (GO:0006743)2.47894147
179microtubule-based movement (GO:0007018)2.47154282
180intra-S DNA damage checkpoint (GO:0031573)2.46039091
181peptidyl-histidine modification (GO:0018202)2.42094930
182regulation of collateral sprouting (GO:0048670)2.40649982
183GPI anchor metabolic process (GO:0006505)2.40464659
184cytochrome complex assembly (GO:0017004)2.40208034
185negative regulation of humoral immune response (GO:0002921)2.39536375
186response to nitrosative stress (GO:0051409)2.37891356
187L-methionine biosynthetic process (GO:0071265)2.37820860
188amino acid salvage (GO:0043102)2.37820860
189L-methionine salvage (GO:0071267)2.37820860
190negative regulation of protein oligomerization (GO:0032460)2.37747270
191coenzyme catabolic process (GO:0009109)2.35974036
192ethanol oxidation (GO:0006069)2.35542643
193negative regulation of neurological system process (GO:0031645)2.34910142
194quinone biosynthetic process (GO:1901663)2.33432761
195drug catabolic process (GO:0042737)2.33095085
196regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.32503331
197neurotransmitter metabolic process (GO:0042133)2.31619255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.30840155
2GBX2_23144817_ChIP-Seq_PC3_Human3.43651613
3ZNF274_21170338_ChIP-Seq_K562_Hela3.40643339
4EZH2_22144423_ChIP-Seq_EOC_Human3.20008810
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.93807102
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69552679
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66144999
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63913435
9TAF15_26573619_Chip-Seq_HEK293_Human2.54872375
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.51172179
11IGF1R_20145208_ChIP-Seq_DFB_Human2.45763706
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27241885
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27241885
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26545974
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21369358
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20025042
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15458064
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.05678115
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.02753555
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01742627
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98553841
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98355025
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97206358
24FUS_26573619_Chip-Seq_HEK293_Human1.96700624
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96473648
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92332336
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89243793
28ER_23166858_ChIP-Seq_MCF-7_Human1.86430420
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85956633
30EWS_26573619_Chip-Seq_HEK293_Human1.85356501
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.85159900
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.84017805
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.83029060
34VDR_22108803_ChIP-Seq_LS180_Human1.82321919
35SMAD4_21799915_ChIP-Seq_A2780_Human1.80050614
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.79940558
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78819350
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78407214
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.75888981
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74370931
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72858774
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70323866
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68404644
44REST_21632747_ChIP-Seq_MESCs_Mouse1.61688732
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.61356016
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61230472
47CBP_20019798_ChIP-Seq_JUKART_Human1.61230472
48P300_19829295_ChIP-Seq_ESCs_Human1.60780250
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60578493
50TP53_22573176_ChIP-Seq_HFKS_Human1.57537032
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55977231
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54879019
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52832737
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52011900
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50274033
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49283127
57AR_21572438_ChIP-Seq_LNCaP_Human1.48724692
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48110099
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47707631
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47474439
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45955977
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.45330369
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44461080
64AR_20517297_ChIP-Seq_VCAP_Human1.43775823
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42579493
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.42579493
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39676395
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39413456
69TCF4_22108803_ChIP-Seq_LS180_Human1.35844126
70RNF2_27304074_Chip-Seq_NSC_Mouse1.35560273
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34747694
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33778662
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33110060
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.32697208
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32017990
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30702530
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.29795966
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28321384
79NCOR_22424771_ChIP-Seq_293T_Human1.25656152
80MYC_19829295_ChIP-Seq_ESCs_Human1.24334070
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.23323166
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21785723
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.21683746
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21468048
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21061775
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21041163
87AR_25329375_ChIP-Seq_VCAP_Human1.20431683
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20402147
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19883695
90HOXB7_26014856_ChIP-Seq_BT474_Human1.19523073
91STAT3_23295773_ChIP-Seq_U87_Human1.18942366
92P53_22387025_ChIP-Seq_ESCs_Mouse1.18614116
93KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18351736
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17873565
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16896106
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.16740793
97SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16622408
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16401658
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.15937077
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15126866
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.14634320
102CDX2_22108803_ChIP-Seq_LS180_Human1.14124061
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13893847
104PHF8_20622853_ChIP-Seq_HELA_Human1.13791210
105AHR_22903824_ChIP-Seq_MCF-7_Human1.13771594
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13693023
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13367734
108ETV1_20927104_ChIP-Seq_GIST48_Human1.12357858
109RUNX2_22187159_ChIP-Seq_PCA_Human1.12110521
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12026828
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.11613116
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.11185465
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.10864795
114OCT4_20526341_ChIP-Seq_ESCs_Human1.10810305
115DROSHA_22980978_ChIP-Seq_HELA_Human1.10651630
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09593879
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.09010776
118BCAT_22108803_ChIP-Seq_LS180_Human1.08996376
119GABP_17652178_ChIP-ChIP_JURKAT_Human1.08949199
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07897024
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07441709
122HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06307366
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05480827
124TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05126398
125EGR1_19032775_ChIP-ChIP_M12_Human1.04690979
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04294937
127IRF8_22096565_ChIP-ChIP_GC-B_Human1.04091382
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03968169
129RBPJ_21746931_ChIP-Seq_IB4_Human1.03494620
130NANOG_20526341_ChIP-Seq_ESCs_Human1.03467214
131P300_18555785_Chip-Seq_ESCs_Mouse1.03267735
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.02931504
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02377205
134NMYC_18555785_Chip-Seq_ESCs_Mouse1.02288895
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01327934
136NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00214537
137CMYC_18555785_Chip-Seq_ESCs_Mouse0.99580950
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99236483
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98913408
140ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98616756
141CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97348842
142CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97224088
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96126069
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96126069
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96074127
146RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95889440
147EZH2_27294783_Chip-Seq_NPCs_Mouse0.95166532
148IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94890059
149NFE2_27457419_Chip-Seq_LIVER_Mouse0.94850307
150PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94432892
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94060369
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.93689069
153SOX2_18555785_Chip-Seq_ESCs_Mouse0.92702418
154RUNX_20019798_ChIP-Seq_JUKART_Human0.91924742
155FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91896500
156RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91832912
157TCF4_23295773_ChIP-Seq_U87_Human0.90431735
158KDM2B_26808549_Chip-Seq_REH_Human0.90234687
159PU1_27457419_Chip-Seq_LIVER_Mouse0.90005601
160SOX2_19829295_ChIP-Seq_ESCs_Human0.89529611
161NANOG_19829295_ChIP-Seq_ESCs_Human0.89529611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception5.86535394
2MP0004147_increased_porphyrin_level4.48944740
3MP0008875_abnormal_xenobiotic_pharmacok4.37984976
4MP0001986_abnormal_taste_sensitivity4.24756730
5MP0003646_muscle_fatigue3.90560812
6MP0006276_abnormal_autonomic_nervous3.30592284
7MP0003195_calcinosis3.17047103
8MP0002837_dystrophic_cardiac_calcinosis3.15615686
9MP0004270_analgesia3.13303464
10MP0002736_abnormal_nociception_after2.82645467
11MP0001348_abnormal_lacrimal_gland2.78171986
12MP0009046_muscle_twitch2.77203032
13MP0004858_abnormal_nervous_system2.74172876
14MP0004043_abnormal_pH_regulation2.66761504
15MP0002102_abnormal_ear_morphology2.65991048
16MP0001968_abnormal_touch/_nociception2.65952316
17MP0002653_abnormal_ependyma_morphology2.65802738
18MP0000372_irregular_coat_pigmentation2.63709021
19MP0000751_myopathy2.53695510
20MP0001188_hyperpigmentation2.46358131
21MP0000749_muscle_degeneration2.38931888
22MP0002734_abnormal_mechanical_nocicepti2.32443551
23MP0002733_abnormal_thermal_nociception2.19816675
24MP0004145_abnormal_muscle_electrophysio2.15874973
25MP0005551_abnormal_eye_electrophysiolog2.11135238
26MP0004036_abnormal_muscle_relaxation2.03786620
27MP0004084_abnormal_cardiac_muscle2.02709503
28MP0004215_abnormal_myocardial_fiber2.01028296
29MP0001970_abnormal_pain_threshold1.97707646
30MP0005646_abnormal_pituitary_gland1.96912258
31MP0005253_abnormal_eye_physiology1.89276545
32MP0004133_heterotaxia1.87010864
33MP0000015_abnormal_ear_pigmentation1.86316631
34MP0005171_absent_coat_pigmentation1.85974767
35MP0002272_abnormal_nervous_system1.85530747
36MP0009780_abnormal_chondrocyte_physiolo1.83317486
37MP0002067_abnormal_sensory_capabilities1.79325367
38MP0008877_abnormal_DNA_methylation1.78966553
39MP0002751_abnormal_autonomic_nervous1.77536088
40MP0002972_abnormal_cardiac_muscle1.75188904
41MP0006072_abnormal_retinal_apoptosis1.74263393
42MP0008569_lethality_at_weaning1.73029561
43MP0002184_abnormal_innervation1.67820246
44MP0001529_abnormal_vocalization1.66627678
45MP0005645_abnormal_hypothalamus_physiol1.62870580
46MP0008872_abnormal_physiological_respon1.61458741
47MP0003828_pulmonary_edema1.59194680
48MP0002822_catalepsy1.57674999
49MP0008789_abnormal_olfactory_epithelium1.57398545
50MP0009379_abnormal_foot_pigmentation1.46676523
51MP0005423_abnormal_somatic_nervous1.46073471
52MP0004484_altered_response_of1.44310293
53MP0004885_abnormal_endolymph1.43703566
54MP0003137_abnormal_impulse_conducting1.42305277
55MP0003880_abnormal_central_pattern1.37533859
56MP0002132_abnormal_respiratory_system1.34855455
57MP0008775_abnormal_heart_ventricle1.33544538
58MP0004085_abnormal_heartbeat1.32091485
59MP0002106_abnormal_muscle_physiology1.30577541
60MP0000566_synostosis1.30089012
61MP0001544_abnormal_cardiovascular_syste1.27757876
62MP0005385_cardiovascular_system_phenoty1.27757876
63MP0005620_abnormal_muscle_contractility1.26701939
64MP0005365_abnormal_bile_salt1.26033137
65MP0003879_abnormal_hair_cell1.25563125
66MP0005330_cardiomyopathy1.23384075
67MP0008260_abnormal_autophagy1.23169862
68MP0000569_abnormal_digit_pigmentation1.22745114
69MP0001764_abnormal_homeostasis1.22435196
70MP0002148_abnormal_hypersensitivity_rea1.21894589
71MP0004142_abnormal_muscle_tone1.19933729
72MP0001765_abnormal_ion_homeostasis1.17544547
73MP0000383_abnormal_hair_follicle1.16844747
74MP0005409_darkened_coat_color1.16263166
75MP0004087_abnormal_muscle_fiber1.14752203
76MP0005332_abnormal_amino_acid1.13166878
77MP0005369_muscle_phenotype1.12337417
78MP0010678_abnormal_skin_adnexa1.11121269
79MP0005085_abnormal_gallbladder_physiolo1.10815069
80MP0005636_abnormal_mineral_homeostasis1.10700618
81MP0001502_abnormal_circadian_rhythm1.10438586
82MP0000759_abnormal_skeletal_muscle1.10125168
83MP0009745_abnormal_behavioral_response1.09809533
84MP0000427_abnormal_hair_cycle1.08696823
85MP0003635_abnormal_synaptic_transmissio1.08313723
86MP0004019_abnormal_vitamin_homeostasis1.08121712
87MP0002168_other_aberrant_phenotype1.07018870
88MP0000631_abnormal_neuroendocrine_gland1.06952240
89MP0005174_abnormal_tail_pigmentation1.06720119
90MP0002693_abnormal_pancreas_physiology1.06540289
91MP0004510_myositis1.06384639
92MP0001486_abnormal_startle_reflex1.06207214
93MP0001944_abnormal_pancreas_morphology1.04919626
94MP0002234_abnormal_pharynx_morphology1.04164152
95MP0003122_maternal_imprinting1.04032211
96MP0003136_yellow_coat_color1.03692654
97MP0000955_abnormal_spinal_cord1.03356862
98MP0005389_reproductive_system_phenotype1.02957382
99MP0001501_abnormal_sleep_pattern1.01818088
100MP0004859_abnormal_synaptic_plasticity1.01380182
101MP0002277_abnormal_respiratory_mucosa0.99304653
102MP0000516_abnormal_urinary_system0.98346010
103MP0005367_renal/urinary_system_phenotyp0.98346010
104MP0002928_abnormal_bile_duct0.98308158
105MP0002064_seizures0.97899256
106MP0003252_abnormal_bile_duct0.93840191
107MP0010329_abnormal_lipoprotein_level0.93626495
108MP0001756_abnormal_urination0.93602440
109MP0003698_abnormal_male_reproductive0.93574158
110MP0002876_abnormal_thyroid_physiology0.93246253
111MP0001905_abnormal_dopamine_level0.91799044
112MP0002229_neurodegeneration0.91325433
113MP0005220_abnormal_exocrine_pancreas0.91119623
114MP0005499_abnormal_olfactory_system0.90015706
115MP0005394_taste/olfaction_phenotype0.90015706
116MP0003806_abnormal_nucleotide_metabolis0.89299661
117MP0001929_abnormal_gametogenesis0.89197595
118MP0002078_abnormal_glucose_homeostasis0.86487650
119MP0002269_muscular_atrophy0.86218759
120MP0010234_abnormal_vibrissa_follicle0.85932161
121MP0005395_other_phenotype0.85488764
122MP0001963_abnormal_hearing_physiology0.84633557
123MP0001919_abnormal_reproductive_system0.82967815
124MP0004811_abnormal_neuron_physiology0.82670785
125MP0002572_abnormal_emotion/affect_behav0.82228313
126MP0005083_abnormal_biliary_tract0.81538037
127MP0008995_early_reproductive_senescence0.80640450
128MP0003718_maternal_effect0.79056110
129MP0003283_abnormal_digestive_organ0.78539202
130MP0006138_congestive_heart_failure0.76993773
131MP0002139_abnormal_hepatobiliary_system0.76849725
132MP0001835_abnormal_antigen_presentation0.76701688
133MP0000747_muscle_weakness0.74498782
134MP0005386_behavior/neurological_phenoty0.73487384
135MP0004924_abnormal_behavior0.73487384
136MP0005671_abnormal_response_to0.72594325
137MP0002909_abnormal_adrenal_gland0.70980971
138MP0001270_distended_abdomen0.70352649
139MP0002332_abnormal_exercise_endurance0.70194613
140MP0002063_abnormal_learning/memory/cond0.69214678
141MP0002095_abnormal_skin_pigmentation0.69213642
142MP0002752_abnormal_somatic_nervous0.68796614
143MP0002066_abnormal_motor_capabilities/c0.68094355
144MP0002882_abnormal_neuron_morphology0.66508104
145MP0005075_abnormal_melanosome_morpholog0.66089488
146MP0000343_altered_response_to0.65891285
147MP0003183_abnormal_peptide_metabolism0.65482158
148MP0004883_abnormal_blood_vessel0.64679660
149MP0004381_abnormal_hair_follicle0.64638807
150MP0001485_abnormal_pinna_reflex0.63695474
151MP0002160_abnormal_reproductive_system0.62065675
152MP0003787_abnormal_imprinting0.61775961
153MP0010630_abnormal_cardiac_muscle0.61037366
154MP0001984_abnormal_olfaction0.60943331
155MP0002638_abnormal_pupillary_reflex0.60296657
156MP0004742_abnormal_vestibular_system0.60257842
157MP0003329_amyloid_beta_deposits0.59928150
158MP0002557_abnormal_social/conspecific_i0.58717685
159MP0009764_decreased_sensitivity_to0.58450279
160MP0001542_abnormal_bone_strength0.58352547
161MP0006036_abnormal_mitochondrial_physio0.58237419
162MP0009697_abnormal_copulation0.57137420
163MP0000750_abnormal_muscle_regeneration0.55774094
164MP0000026_abnormal_inner_ear0.55542820

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.30864054
2Absent/shortened dynein arms (HP:0200106)7.30864054
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.23176651
4Abnormal respiratory motile cilium morphology (HP:0005938)7.17781899
5Abnormal respiratory epithelium morphology (HP:0012253)7.17781899
6Abnormal ciliary motility (HP:0012262)6.76529298
7Ulnar claw (HP:0001178)6.74167668
8Abnormal respiratory motile cilium physiology (HP:0012261)6.63310370
9Rhinitis (HP:0012384)6.03484154
10Febrile seizures (HP:0002373)5.37383705
11Hypothermia (HP:0002045)4.63935150
12Chronic bronchitis (HP:0004469)4.56826438
13Distal lower limb muscle weakness (HP:0009053)4.38335081
14Bronchiectasis (HP:0002110)4.37725383
15Myokymia (HP:0002411)4.29964505
16Focal motor seizures (HP:0011153)4.19245838
17Action tremor (HP:0002345)4.18236309
18Areflexia of lower limbs (HP:0002522)4.17243587
19True hermaphroditism (HP:0010459)4.07408619
20Pancreatic fibrosis (HP:0100732)4.07160616
21Pancreatic cysts (HP:0001737)4.02145488
22Calf muscle hypertrophy (HP:0008981)3.97691821
23Sudden death (HP:0001699)3.94265704
24Atrial fibrillation (HP:0005110)3.84074074
25Muscle hypertrophy of the lower extremities (HP:0008968)3.80455333
26Molar tooth sign on MRI (HP:0002419)3.78894916
27Abnormality of midbrain morphology (HP:0002418)3.78894916
28Nephronophthisis (HP:0000090)3.69381462
29Myotonia (HP:0002486)3.60769019
30Foot dorsiflexor weakness (HP:0009027)3.60708451
31Hyporeflexia of lower limbs (HP:0002600)3.57291366
32Primary atrial arrhythmia (HP:0001692)3.54503065
33Segmental peripheral demyelination/remyelination (HP:0003481)3.51956803
34Steppage gait (HP:0003376)3.51462767
35Supraventricular tachycardia (HP:0004755)3.41321576
36Ventricular fibrillation (HP:0001663)3.41110043
37Bradycardia (HP:0001662)3.40660511
38Chronic hepatic failure (HP:0100626)3.33800897
39Ventricular tachycardia (HP:0004756)3.31969724
40Nasal polyposis (HP:0100582)3.27915061
41Prolonged QT interval (HP:0001657)3.27406261
42Supraventricular arrhythmia (HP:0005115)3.27341036
43Atonic seizures (HP:0010819)3.26172685
44Abnormality of the foot musculature (HP:0001436)3.26086656
45Fetal akinesia sequence (HP:0001989)3.20064705
46Pheochromocytoma (HP:0002666)3.16097229
47Abnormality of the renal medulla (HP:0100957)3.15954565
48Cystic liver disease (HP:0006706)3.12824006
49Neuroendocrine neoplasm (HP:0100634)3.09466094
50Palpitations (HP:0001962)3.02607991
51Occipital encephalocele (HP:0002085)2.97914306
52Medial flaring of the eyebrow (HP:0010747)2.96821064
53Abnormality of the calf musculature (HP:0001430)2.95914731
54Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.93305808
55Bundle branch block (HP:0011710)2.91600928
56Submucous cleft hard palate (HP:0000176)2.81917748
57Exercise-induced myalgia (HP:0003738)2.80098412
58Muscle fiber splitting (HP:0003555)2.75334174
59Heart block (HP:0012722)2.70780033
60Syncope (HP:0001279)2.69169516
61EMG: myopathic abnormalities (HP:0003458)2.67734377
62Chronic sinusitis (HP:0011109)2.64694188
63Lipoatrophy (HP:0100578)2.62860352
64Subaortic stenosis (HP:0001682)2.61861858
65Abnormality of the left ventricular outflow tract (HP:0011103)2.61861858
66Exercise-induced muscle cramps (HP:0003710)2.60873101
67Abnormal atrioventricular conduction (HP:0005150)2.60825073
68Muscle stiffness (HP:0003552)2.60596161
69Tubular atrophy (HP:0000092)2.60550144
70Progressive cerebellar ataxia (HP:0002073)2.58711844
71Abnormal EKG (HP:0003115)2.57275776
72Ketoacidosis (HP:0001993)2.49430842
73Acute necrotizing encephalopathy (HP:0006965)2.44609288
74Attenuation of retinal blood vessels (HP:0007843)2.44038835
75Infertility (HP:0000789)2.42178535
76Recurrent sinusitis (HP:0011108)2.40834871
77Abnormality of the renal cortex (HP:0011035)2.40368391
78Congenital stationary night blindness (HP:0007642)2.40360956
79Postaxial foot polydactyly (HP:0001830)2.40262656
80Abnormality of the nasal mucosa (HP:0000433)2.39807924
81Abnormal drinking behavior (HP:0030082)2.37219914
82Polydipsia (HP:0001959)2.37219914
83Hepatocellular necrosis (HP:0001404)2.37012700
84Distal arthrogryposis (HP:0005684)2.35170751
85Mitochondrial inheritance (HP:0001427)2.32393208
86Congenital primary aphakia (HP:0007707)2.31724403
87Gait imbalance (HP:0002141)2.31499303
88Aplasia/Hypoplasia of the tongue (HP:0010295)2.30505287
89Congenital hepatic fibrosis (HP:0002612)2.28928765
90Abnormality of alanine metabolism (HP:0010916)2.28854201
91Hyperalaninemia (HP:0003348)2.28854201
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28854201
93Abnormal mitochondria in muscle tissue (HP:0008316)2.28333242
94Male pseudohermaphroditism (HP:0000037)2.26347943
95Left ventricular hypertrophy (HP:0001712)2.25701766
96Focal seizures (HP:0007359)2.24808149
97Impaired pain sensation (HP:0007328)2.24229150
98Abnormality of pain sensation (HP:0010832)2.24229150
99Bronchitis (HP:0012387)2.23869144
100Gaze-evoked nystagmus (HP:0000640)2.22441904
101Hepatic necrosis (HP:0002605)2.21856228
102Decreased central vision (HP:0007663)2.19844773
103Decreased motor nerve conduction velocity (HP:0003431)2.19390347
104Abnormal rod and cone electroretinograms (HP:0008323)2.18653804
105Decreased circulating renin level (HP:0003351)2.18262144
106Atrioventricular block (HP:0001678)2.17639265
107Hyperactive renin-angiotensin system (HP:0000841)2.16209538
108Nephrogenic diabetes insipidus (HP:0009806)2.14387348
109Type II lissencephaly (HP:0007260)2.13804096
110Furrowed tongue (HP:0000221)2.13198524
111Dilated cardiomyopathy (HP:0001644)2.12164861
112Tubulointerstitial nephritis (HP:0001970)2.12055382
113Sclerocornea (HP:0000647)2.11826734
114Absent speech (HP:0001344)2.09461625
115Hyperinsulinemic hypoglycemia (HP:0000825)2.08554356
116Increased CSF lactate (HP:0002490)2.06997888
117Generalized tonic-clonic seizures (HP:0002069)2.06398749
118Autoamputation (HP:0001218)2.03524053
119Progressive macrocephaly (HP:0004481)2.03186525
120Abnormal hair whorl (HP:0010721)2.02674014
121Hyperkalemia (HP:0002153)2.02264279
122Postaxial hand polydactyly (HP:0001162)2.01716665
123Polyuria (HP:0000103)2.01706617
124Hypokalemic alkalosis (HP:0001949)2.00137578
125Anencephaly (HP:0002323)1.99193641
126Muscle fiber inclusion bodies (HP:0100299)1.98860097
127Ventricular arrhythmia (HP:0004308)1.97736655
128Absence seizures (HP:0002121)1.97213381
129Epileptic encephalopathy (HP:0200134)1.95806485
130Tinnitus (HP:0000360)1.95549939
131Methylmalonic acidemia (HP:0002912)1.95418867
132Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.94886979
133Right ventricular cardiomyopathy (HP:0011663)1.94293233
134Large for gestational age (HP:0001520)1.93254356
135Abolished electroretinogram (ERG) (HP:0000550)1.93131741
136Abnormality of renin-angiotensin system (HP:0000847)1.91719577
137Impaired proprioception (HP:0010831)1.89861205
138Bony spicule pigmentary retinopathy (HP:0007737)1.89545712
139Ketosis (HP:0001946)1.88472801
140Prostate neoplasm (HP:0100787)1.88138466
141Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87954613
142Onion bulb formation (HP:0003383)1.87486747
143Renal salt wasting (HP:0000127)1.84900677
144Slow saccadic eye movements (HP:0000514)1.84100176
145Abnormal biliary tract physiology (HP:0012439)1.83741317
146Bile duct proliferation (HP:0001408)1.83741317
147Abnormality of the vocal cords (HP:0008777)1.83450953
148Distal sensory impairment (HP:0002936)1.83255018
149Distal lower limb amyotrophy (HP:0008944)1.83026991
150Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82977212
151Hammertoe (HP:0001765)1.82108332
152Mask-like facies (HP:0000298)1.81636855
153Hypercortisolism (HP:0001578)1.80984052
154Aplasia/Hypoplasia of the spleen (HP:0010451)1.80954092
155Nemaline bodies (HP:0003798)1.80286037
156Recurrent abscess formation (HP:0002722)1.79986200
157Lactic acidosis (HP:0003128)1.79744493
158Failure to thrive in infancy (HP:0001531)1.79053119
159Supranuclear gaze palsy (HP:0000605)1.79043300
160Asymmetric septal hypertrophy (HP:0001670)1.78174436
161Optic nerve hypoplasia (HP:0000609)1.77135206
162Chronic otitis media (HP:0000389)1.75752375
163Thyroid carcinoma (HP:0002890)1.74827870
164Hypomagnesemia (HP:0002917)1.74793054
165Myoglobinuria (HP:0002913)1.74323581
166Male infertility (HP:0003251)1.73104131
167Hyperaldosteronism (HP:0000859)1.72909762
168Ankle clonus (HP:0011448)1.72804335
169Dialeptic seizures (HP:0011146)1.72653493
170EMG: neuropathic changes (HP:0003445)1.72160449
171Abnormality of chloride homeostasis (HP:0011422)1.71287954
172Asplenia (HP:0001746)1.69610008
173Recurrent otitis media (HP:0000403)1.68107929
174Oculomotor apraxia (HP:0000657)1.66000262
175Methylmalonic aciduria (HP:0012120)1.63457891
176Abnormal urine output (HP:0012590)1.63444865
177Genital tract atresia (HP:0001827)1.62958989
178Abnormality of macular pigmentation (HP:0008002)1.57887552
179Retinitis pigmentosa (HP:0000510)1.57529669
180Abnormality of endocrine pancreas physiology (HP:0012093)1.57061216
181Abnormality of the pancreatic islet cells (HP:0006476)1.57061216
182Vaginal atresia (HP:0000148)1.57004097
183Abnormality of renal excretion (HP:0011036)1.56396780
184Hemiparesis (HP:0001269)1.55096219
185Hyperglycemia (HP:0003074)1.54831067
186Decreased electroretinogram (ERG) amplitude (HP:0000654)1.54159585
187Retinal dysplasia (HP:0007973)1.53222600
188Tubulointerstitial abnormality (HP:0001969)1.50808050
189Constricted visual fields (HP:0001133)1.50626431
190Dyschromatopsia (HP:0007641)1.48267780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.51188688
2LMTK24.05350146
3CASK4.00750092
4MAPK153.85315370
5MAP4K23.34618335
6NTRK33.17779361
7MAPKAPK32.94921060
8TRIM282.80394707
9NEK92.71247115
10MINK12.65527389
11PHKG22.63203488
12PHKG12.63203488
13SIK32.44535364
14PINK12.32434885
15GRK72.26616190
16MAP2K72.24936619
17WNK32.22374422
18BCR2.15749230
19SGK21.97551434
20MAP3K121.97253293
21STK241.95626766
22MAP3K141.93145414
23MUSK1.92809748
24MATK1.88561899
25GRK11.87876491
26ZAK1.80680443
27WNK11.73644952
28EPHA31.67908537
29OXSR11.66682643
30EPHA41.64277153
31EIF2AK31.61370731
32MAPK131.60425840
33YES11.53913415
34NTRK11.51751368
35NUAK11.47663348
36OBSCN1.47381416
37SGK2231.30511002
38SGK4941.30511002
39TLK11.30138008
40SGK31.30030174
41IRAK41.28214939
42NME11.24675856
43CAMKK21.23873266
44FGFR21.23042895
45PLK21.22278859
46STK391.21913521
47PAK31.20935451
48MAP3K111.20556181
49IRAK31.20544293
50TXK1.18136132
51PRPF4B1.17482617
52CSNK1G31.12151391
53RPS6KA21.10931122
54TTN1.05620822
55TNK21.05475502
56BLK1.05132365
57DAPK21.04561677
58ACVR1B1.04422941
59CSNK1A1L1.04087310
60ADRBK21.03871419
61CSNK1G21.03120198
62BMPR21.01214302
63CSNK1G11.00255039
64TIE11.00163505
65MAP2K40.99725245
66TRPM70.99711288
67DYRK20.99699931
68EIF2AK10.99434503
69MAP3K70.97794415
70MYLK0.95552503
71RPS6KL10.91407855
72RPS6KC10.91407855
73EPHA20.86915119
74AKT30.86078506
75PIM20.83369608
76TEC0.82859222
77PTK2B0.82121449
78BRSK20.81900966
79RPS6KA60.80962597
80CCNB10.80102852
81BCKDK0.79791474
82PRKCI0.79642906
83TNIK0.79232036
84NLK0.77459010
85BMPR1B0.75210866
86LATS20.73610727
87MARK10.73358022
88PRKAA20.70662208
89MAP3K40.70419317
90PRKCE0.70404745
91ADRBK10.68626566
92CAMK2G0.68474834
93FER0.68313835
94PLK30.67589817
95STK38L0.67070622
96ARAF0.67001212
97MST40.66883735
98INSRR0.66579687
99IRAK10.62363903
100MAP4K10.62171393
101MAP2K60.60235920
102MAP3K10.59868608
103JAK10.59078149
104PRKCG0.59033771
105PRKAA10.56798637
106CAMK2D0.56026129
107BRAF0.55026768
108SYK0.54942880
109NEK10.54607390
110VRK10.54079288
111LATS10.53848220
112ERBB30.53766185
113SCYL20.53529652
114EPHB10.51757743
115CAMK2A0.50826639
116IRAK20.50513833
117LIMK10.49768417
118CDK190.49388980
119PKN10.48185012
120EIF2AK20.48114229
121STK110.47705417
122WNK40.47304923
123CSNK1A10.46008438
124HIPK20.45376736
125DMPK0.44613448
126TAOK30.44440140
127CAMK10.43787868
128PRKACA0.43421349
129MAP2K10.42581833
130MAP2K30.41541185
131PLK10.41399951
132PRKACB0.41300925
133MARK30.39841420
134MAP3K20.39215534
135CDC42BPA0.38421912
136IKBKE0.38080344
137CSNK1D0.37397898
138STK30.37182645
139RPS6KB10.36570975
140FGFR30.35298335
141MKNK20.35181813
142RIPK40.34696833
143ROCK20.34410957
144PRKG10.34338440
145PIK3CA0.34206539
146PRKCH0.33954165
147PDK30.33124451
148PDK40.33124451
149GRK50.31375317
150ROCK10.30223168
151STK380.29809087
152PRKCQ0.29410998
153PRKCA0.28869562
154MAPKAPK50.28645547
155WEE10.24469623
156TTK0.23164924
157NEK60.21103166
158CDK50.20774151

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.33458745
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.99263366
3Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.97189275
4Butanoate metabolism_Homo sapiens_hsa006502.55876858
5Cardiac muscle contraction_Homo sapiens_hsa042602.50798185
6Oxidative phosphorylation_Homo sapiens_hsa001902.49560722
7Synaptic vesicle cycle_Homo sapiens_hsa047212.36370637
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34710260
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26334765
10Parkinsons disease_Homo sapiens_hsa050122.24984699
11Taste transduction_Homo sapiens_hsa047422.20634604
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.17780153
13Olfactory transduction_Homo sapiens_hsa047402.12473932
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.12062879
15Chemical carcinogenesis_Homo sapiens_hsa052042.10830268
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08334392
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.06897165
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05612530
19Phototransduction_Homo sapiens_hsa047442.04122163
20Protein export_Homo sapiens_hsa030602.00424159
21Histidine metabolism_Homo sapiens_hsa003402.00244809
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99048457
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.91264318
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90645396
25Alzheimers disease_Homo sapiens_hsa050101.90604158
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85895260
27Dilated cardiomyopathy_Homo sapiens_hsa054141.85653036
28beta-Alanine metabolism_Homo sapiens_hsa004101.84955779
29Propanoate metabolism_Homo sapiens_hsa006401.83132785
30Peroxisome_Homo sapiens_hsa041461.78178734
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70681151
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70498295
33Linoleic acid metabolism_Homo sapiens_hsa005911.69243241
34Nitrogen metabolism_Homo sapiens_hsa009101.67018147
35Nicotine addiction_Homo sapiens_hsa050331.59422163
36Caffeine metabolism_Homo sapiens_hsa002321.54939458
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.54088415
38Salmonella infection_Homo sapiens_hsa051321.49855235
39Huntingtons disease_Homo sapiens_hsa050161.49395098
40Calcium signaling pathway_Homo sapiens_hsa040201.48586640
41Phenylalanine metabolism_Homo sapiens_hsa003601.45624901
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45508985
43Tryptophan metabolism_Homo sapiens_hsa003801.45475855
44Fatty acid degradation_Homo sapiens_hsa000711.44799040
45Serotonergic synapse_Homo sapiens_hsa047261.41665176
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38466496
47Circadian entrainment_Homo sapiens_hsa047131.38449433
48ABC transporters_Homo sapiens_hsa020101.38128506
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36682714
50Circadian rhythm_Homo sapiens_hsa047101.34784965
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34151526
52Tyrosine metabolism_Homo sapiens_hsa003501.31739234
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31528692
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.26892807
55Cholinergic synapse_Homo sapiens_hsa047251.26123764
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24934732
57Retinol metabolism_Homo sapiens_hsa008301.24486272
58Regulation of autophagy_Homo sapiens_hsa041401.24067780
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24037541
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23141955
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17797230
62Insulin secretion_Homo sapiens_hsa049111.13127379
63Glutamatergic synapse_Homo sapiens_hsa047241.12316815
64Phagosome_Homo sapiens_hsa041451.11191977
65Steroid biosynthesis_Homo sapiens_hsa001001.07870682
66Glutathione metabolism_Homo sapiens_hsa004801.07637044
67Proteasome_Homo sapiens_hsa030501.05353734
68Steroid hormone biosynthesis_Homo sapiens_hsa001401.05060424
69Type I diabetes mellitus_Homo sapiens_hsa049401.04360044
70Neurotrophin signaling pathway_Homo sapiens_hsa047221.03052376
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00329897
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97533520
73Oxytocin signaling pathway_Homo sapiens_hsa049210.96676427
74Long-term potentiation_Homo sapiens_hsa047200.96113141
75Morphine addiction_Homo sapiens_hsa050320.94331712
76Fatty acid elongation_Homo sapiens_hsa000620.93688885
77Leishmaniasis_Homo sapiens_hsa051400.93234236
78Gastric acid secretion_Homo sapiens_hsa049710.92479147
79Rheumatoid arthritis_Homo sapiens_hsa053230.91939699
80Fatty acid metabolism_Homo sapiens_hsa012120.90669555
81Dopaminergic synapse_Homo sapiens_hsa047280.90445942
82Viral myocarditis_Homo sapiens_hsa054160.90193272
83Basal transcription factors_Homo sapiens_hsa030220.89715969
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88207027
85Fanconi anemia pathway_Homo sapiens_hsa034600.86977040
86Allograft rejection_Homo sapiens_hsa053300.85831895
87Melanoma_Homo sapiens_hsa052180.85815872
88Salivary secretion_Homo sapiens_hsa049700.85272561
89Tuberculosis_Homo sapiens_hsa051520.85198110
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84315729
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83969679
92Arginine and proline metabolism_Homo sapiens_hsa003300.81896027
93Arachidonic acid metabolism_Homo sapiens_hsa005900.80974295
94cAMP signaling pathway_Homo sapiens_hsa040240.80476456
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76722250
96Renin secretion_Homo sapiens_hsa049240.76383077
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75041501
98Collecting duct acid secretion_Homo sapiens_hsa049660.75019154
99GnRH signaling pathway_Homo sapiens_hsa049120.73748718
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.73271602
101Metabolic pathways_Homo sapiens_hsa011000.72290372
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70081578
103MAPK signaling pathway_Homo sapiens_hsa040100.69618243
104Measles_Homo sapiens_hsa051620.69199641
105Pyruvate metabolism_Homo sapiens_hsa006200.68927689
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68490379
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67683051
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65188970
109Selenocompound metabolism_Homo sapiens_hsa004500.64632197
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.63720378
111Long-term depression_Homo sapiens_hsa047300.63382866
112Insulin signaling pathway_Homo sapiens_hsa049100.63228097
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62871175
114Fat digestion and absorption_Homo sapiens_hsa049750.62429190
115Sulfur metabolism_Homo sapiens_hsa009200.62363946
116Thyroid cancer_Homo sapiens_hsa052160.61802632
117Graft-versus-host disease_Homo sapiens_hsa053320.60894910
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59192357
119Chemokine signaling pathway_Homo sapiens_hsa040620.58632935
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58518271
121Non-homologous end-joining_Homo sapiens_hsa034500.57800537
122Asthma_Homo sapiens_hsa053100.57344107
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56979843
124GABAergic synapse_Homo sapiens_hsa047270.56876726
125Inositol phosphate metabolism_Homo sapiens_hsa005620.56628404
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56249911
127Sphingolipid metabolism_Homo sapiens_hsa006000.55549476
128Ras signaling pathway_Homo sapiens_hsa040140.54416598
129Prolactin signaling pathway_Homo sapiens_hsa049170.54070622
130Platelet activation_Homo sapiens_hsa046110.52998229
131RNA degradation_Homo sapiens_hsa030180.52182681
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51945321
133Epstein-Barr virus infection_Homo sapiens_hsa051690.51227639
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50489031
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.49997273
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.49893130
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49665627
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49654019
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49587998
140Apoptosis_Homo sapiens_hsa042100.49237226
141Amphetamine addiction_Homo sapiens_hsa050310.49132257
142ErbB signaling pathway_Homo sapiens_hsa040120.49061283
143Homologous recombination_Homo sapiens_hsa034400.48945691
144Type II diabetes mellitus_Homo sapiens_hsa049300.48586275
145Pertussis_Homo sapiens_hsa051330.48362296
146Osteoclast differentiation_Homo sapiens_hsa043800.46832172
147Toxoplasmosis_Homo sapiens_hsa051450.46760647
148Primary immunodeficiency_Homo sapiens_hsa053400.46462540
149Ovarian steroidogenesis_Homo sapiens_hsa049130.46222291
150Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45991627
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45790628
152Glycerolipid metabolism_Homo sapiens_hsa005610.44260600
153Starch and sucrose metabolism_Homo sapiens_hsa005000.43322803
154Ether lipid metabolism_Homo sapiens_hsa005650.43271409
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43181036
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42832619
157Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42831913
158Vitamin digestion and absorption_Homo sapiens_hsa049770.42696209
159Glucagon signaling pathway_Homo sapiens_hsa049220.42209819
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.42148953
161Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41983603
162Influenza A_Homo sapiens_hsa051640.41622069
163Purine metabolism_Homo sapiens_hsa002300.40372372
164Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39692602
165Cocaine addiction_Homo sapiens_hsa050300.37377420
166One carbon pool by folate_Homo sapiens_hsa006700.36432134

Most similar genes based on co-expression Upload to Enrichr

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