VWC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)7.51806159
2regulation of odontogenesis of dentin-containing tooth (GO:0042487)7.46788088
3lipopolysaccharide biosynthetic process (GO:0009103)7.43245761
4protein-chromophore linkage (GO:0018298)7.34965979
5regulation of meiosis I (GO:0060631)6.88499438
6regulation of protein glycosylation (GO:0060049)6.77566479
7lipopolysaccharide metabolic process (GO:0008653)6.41196081
8regulation of pigment cell differentiation (GO:0050932)6.30472383
9negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.30346829
10negative regulation of glycoprotein biosynthetic process (GO:0010561)6.24334791
11sulfate transmembrane transport (GO:1902358)6.16040293
12positive regulation of developmental pigmentation (GO:0048087)6.07762107
13gamma-aminobutyric acid transport (GO:0015812)5.66304224
14negative regulation of synaptic transmission, GABAergic (GO:0032229)5.63202417
15neuron cell-cell adhesion (GO:0007158)5.62934986
16paraxial mesoderm development (GO:0048339)5.61509159
17regulation of short-term neuronal synaptic plasticity (GO:0048172)5.57529807
18vocalization behavior (GO:0071625)5.56063029
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51835395
20SMAD protein complex assembly (GO:0007183)5.43993104
21negative regulation of cell cycle G2/M phase transition (GO:1902750)5.43286847
22sulfate transport (GO:0008272)5.28561149
23synaptic vesicle exocytosis (GO:0016079)5.25828613
24regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.20334905
25neuronal action potential propagation (GO:0019227)5.04630654
26neurotransmitter secretion (GO:0007269)4.99716093
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.97331858
28L-phenylalanine catabolic process (GO:0006559)4.97331858
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.83426582
30glutamate secretion (GO:0014047)4.74316120
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.73042626
32neuromuscular process controlling posture (GO:0050884)4.72917177
33regulation of synaptic vesicle exocytosis (GO:2000300)4.69301755
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.69295375
35positive regulation of meiosis (GO:0045836)4.67396983
36negative regulation of glycoprotein metabolic process (GO:1903019)4.58063223
37gamma-aminobutyric acid signaling pathway (GO:0007214)4.56745059
38tyrosine metabolic process (GO:0006570)4.43392606
39regulation of glutamate receptor signaling pathway (GO:1900449)4.42917121
40serotonin receptor signaling pathway (GO:0007210)4.37017206
41protein localization to synapse (GO:0035418)4.36286231
42heme transport (GO:0015886)4.35017866
43startle response (GO:0001964)4.32472099
44positive regulation of meiotic cell cycle (GO:0051446)4.32458721
45notochord development (GO:0030903)4.32185252
46regulation of synaptic vesicle transport (GO:1902803)4.20421840
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.14300102
48synaptic vesicle maturation (GO:0016188)4.11732594
49L-phenylalanine metabolic process (GO:0006558)4.11195019
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.11195019
51proline transport (GO:0015824)4.07286919
52neurotransmitter transport (GO:0006836)4.03168883
53ionotropic glutamate receptor signaling pathway (GO:0035235)4.02061972
54glutamate receptor signaling pathway (GO:0007215)4.01479415
55regulation of transforming growth factor beta2 production (GO:0032909)4.00422251
56ribonucleoprotein complex disassembly (GO:0032988)4.00099416
57neuron recognition (GO:0008038)3.99173744
58response to pheromone (GO:0019236)3.99046115
59cerebellar Purkinje cell differentiation (GO:0021702)3.90488633
60regulation of rhodopsin mediated signaling pathway (GO:0022400)3.90331539
61locomotory exploration behavior (GO:0035641)3.87252977
62neuron-neuron synaptic transmission (GO:0007270)3.82317998
63layer formation in cerebral cortex (GO:0021819)3.81687801
64regulation of neurotransmitter levels (GO:0001505)3.80521558
65detection of calcium ion (GO:0005513)3.79959005
66response to epinephrine (GO:0071871)3.75722706
67transmission of nerve impulse (GO:0019226)3.75156481
68positive regulation of synapse assembly (GO:0051965)3.73648596
69succinate metabolic process (GO:0006105)3.68815693
70righting reflex (GO:0060013)3.68480965
71centriole replication (GO:0007099)3.66872798
72neurotransmitter-gated ion channel clustering (GO:0072578)3.64111053
73epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.63883306
74exploration behavior (GO:0035640)3.63514597
75synaptic vesicle docking involved in exocytosis (GO:0016081)3.63061297
76membrane hyperpolarization (GO:0060081)3.59915802
77regulation of protein kinase A signaling (GO:0010738)3.59837362
78rhodopsin mediated signaling pathway (GO:0016056)3.58420171
79synaptic transmission, glutamatergic (GO:0035249)3.58270513
80tachykinin receptor signaling pathway (GO:0007217)3.56534757
81heart valve formation (GO:0003188)3.52068790
82regulation of synaptic transmission, GABAergic (GO:0032228)3.51749108
83glycerol metabolic process (GO:0006071)3.48861844
84iron coordination entity transport (GO:1901678)3.48791552
85presynaptic membrane assembly (GO:0097105)3.48430141
86axonal fasciculation (GO:0007413)3.48286648
87regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48030155
88toxin metabolic process (GO:0009404)3.47129369
89meiotic chromosome segregation (GO:0045132)3.46054111
90response to histamine (GO:0034776)3.44269440
91vitamin transmembrane transport (GO:0035461)3.42450799
92regulation of postsynaptic membrane potential (GO:0060078)3.41249316
93regulation of neuronal synaptic plasticity (GO:0048168)3.41033378
94regulation of interleukin-5 production (GO:0032674)3.40391261
95sympathetic nervous system development (GO:0048485)3.39368152
96nodal signaling pathway (GO:0038092)3.38800807
97regulation of nuclear cell cycle DNA replication (GO:0033262)3.36106347
98negative regulation of stem cell proliferation (GO:2000647)3.34719715
99postsynaptic membrane organization (GO:0001941)3.32451041
100positive regulation of amino acid transport (GO:0051957)3.31358406
101regulation of synaptic transmission, glutamatergic (GO:0051966)3.30261702
102aromatic amino acid family catabolic process (GO:0009074)3.28608867
103somite rostral/caudal axis specification (GO:0032525)3.27534089
104aspartate family amino acid catabolic process (GO:0009068)3.24963341
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24868062
106cAMP-mediated signaling (GO:0019933)3.24785714
107regulation of excitatory postsynaptic membrane potential (GO:0060079)3.24107878
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.21075906
109regulation of odontogenesis (GO:0042481)3.20714390
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.19817900
111response to mercury ion (GO:0046689)3.19668666
112presynaptic membrane organization (GO:0097090)3.19126095
113positive regulation of membrane potential (GO:0045838)3.18934511
114germinal center formation (GO:0002467)3.18595508
115positive regulation of action potential (GO:0045760)3.18383581
116regulation of glutamate secretion (GO:0014048)3.18182469
117negative regulation of cytosolic calcium ion concentration (GO:0051481)3.15154691
118regulation of vesicle fusion (GO:0031338)3.12317566
119organelle disassembly (GO:1903008)3.11215677
120regulation of developmental pigmentation (GO:0048070)3.10772058
121pantothenate metabolic process (GO:0015939)3.08880264
122negative regulation of neural precursor cell proliferation (GO:2000178)3.08062499
123flavonoid metabolic process (GO:0009812)3.07101184
124dendritic spine morphogenesis (GO:0060997)3.06563738
125social behavior (GO:0035176)3.04171124
126intraspecies interaction between organisms (GO:0051703)3.04171124
127sulfur compound transport (GO:0072348)3.04087003
128synapse assembly (GO:0007416)3.03700455
129alditol metabolic process (GO:0019400)3.01074893
130protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)2.99719439
131synaptic vesicle endocytosis (GO:0048488)2.98751566
132positive regulation of SMAD protein import into nucleus (GO:0060391)2.98201108
133synaptic transmission (GO:0007268)2.97646544
134activation of protein kinase A activity (GO:0034199)2.97310538
135ATP hydrolysis coupled proton transport (GO:0015991)2.97014116
136energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.97014116
137chaperone-mediated protein transport (GO:0072321)2.96711070
138adult walking behavior (GO:0007628)2.95598367
139long-term memory (GO:0007616)2.95106329
140regulation of synapse assembly (GO:0051963)2.94232159
141positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93081130
142positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93015255
143regulation of neurotransmitter secretion (GO:0046928)2.92591612
144striatum development (GO:0021756)2.89532046
145piRNA metabolic process (GO:0034587)2.89287658
146mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89096504
147regulation of cAMP-dependent protein kinase activity (GO:2000479)2.88480344
148DNA damage induced protein phosphorylation (GO:0006975)2.88165116
149mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.87464832
150neurotransmitter metabolic process (GO:0042133)2.84880490
151calcium ion-dependent exocytosis (GO:0017156)2.84736868
152positive regulation of potassium ion transmembrane transport (GO:1901381)2.84460442
153regulation of dendritic spine morphogenesis (GO:0061001)2.83865869
154regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83615410
155serotonin metabolic process (GO:0042428)2.83091942
156regulation of respiratory system process (GO:0044065)2.82245092
157lysine catabolic process (GO:0006554)2.82195822
158lysine metabolic process (GO:0006553)2.82195822
159negative regulation of amino acid transport (GO:0051956)2.82040906
160establishment of synaptic vesicle localization (GO:0097480)2.81890541
161synaptic vesicle transport (GO:0048489)2.81890541
162neurotransmitter biosynthetic process (GO:0042136)2.80529075
163membrane depolarization (GO:0051899)2.80134634
164long-term synaptic potentiation (GO:0060291)2.80118440
165behavioral fear response (GO:0001662)2.79985054
166behavioral defense response (GO:0002209)2.79985054
167regulation of synapse structural plasticity (GO:0051823)2.79799398
168regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.78575844
169cellular response to gamma radiation (GO:0071480)2.76506163
170aromatic amino acid family metabolic process (GO:0009072)2.76028471
171organ induction (GO:0001759)2.71026242
172negative regulation of cell-matrix adhesion (GO:0001953)2.67779075
173behavioral response to ethanol (GO:0048149)2.67441458
174biotin metabolic process (GO:0006768)2.66608663
175detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.65864602
176regulation of keratinocyte proliferation (GO:0010837)2.64810685
177opioid receptor signaling pathway (GO:0038003)2.63866997
178inflammatory response to antigenic stimulus (GO:0002437)2.63294160
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61644694
180phasic smooth muscle contraction (GO:0014821)2.60788151
181cofactor transport (GO:0051181)2.59663064
182SMAD protein signal transduction (GO:0060395)2.58173488
183regulation of hair follicle development (GO:0051797)2.57912965
184primary amino compound metabolic process (GO:1901160)2.57856230
185sphingosine metabolic process (GO:0006670)14.1070778
186diol metabolic process (GO:0034311)12.8269770
187sphingoid metabolic process (GO:0046519)11.5473851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.42074120
2GBX2_23144817_ChIP-Seq_PC3_Human3.79403523
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03593515
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97628526
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85259559
6* EZH2_27304074_Chip-Seq_ESCs_Mouse2.56952865
7TAF15_26573619_Chip-Seq_HEK293_Human2.55082330
8REST_21632747_ChIP-Seq_MESCs_Mouse2.49718473
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47973025
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47973025
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47356809
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46033895
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41578015
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.41323109
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37940906
16* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35941243
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31285865
18AR_21572438_ChIP-Seq_LNCaP_Human2.31204986
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.28431450
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24857118
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.24807189
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24217972
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06090770
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03650857
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.00339282
26* EZH2_27294783_Chip-Seq_ESCs_Mouse1.99965780
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.97527356
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97099208
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93686227
30DROSHA_22980978_ChIP-Seq_HELA_Human1.91741986
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91683832
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90882288
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88366917
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85147515
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.85065792
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.81565543
37P300_19829295_ChIP-Seq_ESCs_Human1.81123325
38IGF1R_20145208_ChIP-Seq_DFB_Human1.76840340
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76387307
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74009035
41* RNF2_27304074_Chip-Seq_NSC_Mouse1.73590054
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.70423109
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68113937
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.66354559
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66286835
46ZNF274_21170338_ChIP-Seq_K562_Hela1.66221411
47NANOG_19829295_ChIP-Seq_ESCs_Human1.65612922
48SOX2_19829295_ChIP-Seq_ESCs_Human1.65612922
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65547627
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65437808
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63262538
52EGR1_19032775_ChIP-ChIP_M12_Human1.58431646
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56257094
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55523410
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52702276
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51467551
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51220182
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.50516122
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.49570619
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.47526066
61AR_25329375_ChIP-Seq_VCAP_Human1.46648096
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.44066905
63FUS_26573619_Chip-Seq_HEK293_Human1.42608907
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40448665
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35426530
66HOXB7_26014856_ChIP-Seq_BT474_Human1.34068840
67ER_23166858_ChIP-Seq_MCF-7_Human1.33596651
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.33245162
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31458913
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30998454
71STAT3_23295773_ChIP-Seq_U87_Human1.29068325
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.28600255
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28580638
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27407325
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.26104260
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.24938073
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23633854
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21643547
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20615335
80JUN_21703547_ChIP-Seq_K562_Human1.18786341
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.18694968
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17992771
83OCT4_20526341_ChIP-Seq_ESCs_Human1.17316633
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16540542
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16453244
86* RING1B_27294783_Chip-Seq_ESCs_Mouse1.15541078
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14699039
88* STAT3_18555785_ChIP-Seq_MESCs_Mouse1.14589306
89* TCF4_23295773_ChIP-Seq_U87_Human1.12703364
90* FLI1_21867929_ChIP-Seq_TH2_Mouse1.12005358
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10795910
92RUNX2_22187159_ChIP-Seq_PCA_Human1.10787938
93NCOR_22424771_ChIP-Seq_293T_Human1.09920507
94TCF4_22108803_ChIP-Seq_LS180_Human1.09867131
95FOXH1_21741376_ChIP-Seq_ESCs_Human1.09437116
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08538365
97TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08214810
98* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08084351
99SMAD3_21741376_ChIP-Seq_ESCs_Human1.08079211
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07898113
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.07573740
102SMAD4_21741376_ChIP-Seq_HESCs_Human1.07511577
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07041553
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06668114
105* AR_19668381_ChIP-Seq_PC3_Human1.06211044
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05975113
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.04822285
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04192531
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04114121
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03690664
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03286373
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02321985
113CBP_20019798_ChIP-Seq_JUKART_Human1.02283367
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02283367
115STAT1_20625510_ChIP-Seq_HELA_Human1.00785963
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00512768
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00512768
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00450710
119SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99907559
120FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99716273
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.99716273
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.98793226
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98393176
124KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98284242
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97935866
126* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97614884
127FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96967243
128VDR_22108803_ChIP-Seq_LS180_Human0.96799544
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96537286
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95661528
131* KDM2B_26808549_Chip-Seq_REH_Human0.95044433
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.93869620
133BCAT_22108803_ChIP-Seq_LS180_Human0.92590632
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.92261925
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91236434
136FLI1_27457419_Chip-Seq_LIVER_Mouse0.90464569
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90399664
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88740575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.07375081
2MP0004859_abnormal_synaptic_plasticity4.74645847
3MP0003880_abnormal_central_pattern4.49970823
4MP0003890_abnormal_embryonic-extraembry4.45642650
5MP0003045_fibrosis4.10802717
6MP0003635_abnormal_synaptic_transmissio3.88253638
7MP0009046_muscle_twitch3.81291808
8MP0000569_abnormal_digit_pigmentation3.42680030
9MP0009745_abnormal_behavioral_response3.34129582
10MP0002064_seizures3.22556678
11MP0002063_abnormal_learning/memory/cond2.96175139
12MP0001501_abnormal_sleep_pattern2.91015684
13MP0006276_abnormal_autonomic_nervous2.89484423
14MP0004270_analgesia2.81244606
15MP0002572_abnormal_emotion/affect_behav2.78192143
16MP0002272_abnormal_nervous_system2.78008534
17MP0001968_abnormal_touch/_nociception2.66115027
18MP0001486_abnormal_startle_reflex2.55476456
19MP0005670_abnormal_white_adipose2.54923890
20MP0002734_abnormal_mechanical_nocicepti2.51887410
21MP0002822_catalepsy2.49159587
22MP0004381_abnormal_hair_follicle2.48376762
23MP0003122_maternal_imprinting2.46414755
24MP0004147_increased_porphyrin_level2.41296289
25MP0005423_abnormal_somatic_nervous2.40161764
26MP0001529_abnormal_vocalization2.32604673
27MP0001440_abnormal_grooming_behavior2.19628175
28MP0002736_abnormal_nociception_after2.16603559
29MP0002735_abnormal_chemical_nociception2.16094004
30MP0004142_abnormal_muscle_tone2.10673462
31MP0003787_abnormal_imprinting1.99493884
32MP0005645_abnormal_hypothalamus_physiol1.99488229
33MP0002067_abnormal_sensory_capabilities1.96411530
34MP0002733_abnormal_thermal_nociception1.95542910
35MP0002184_abnormal_innervation1.93562209
36MP0005386_behavior/neurological_phenoty1.89409587
37MP0004924_abnormal_behavior1.89409587
38MP0002557_abnormal_social/conspecific_i1.87272879
39MP0005085_abnormal_gallbladder_physiolo1.84092404
40MP0000749_muscle_degeneration1.83901711
41MP0001970_abnormal_pain_threshold1.82592455
42MP0005646_abnormal_pituitary_gland1.77995034
43MP0002837_dystrophic_cardiac_calcinosis1.74370957
44MP0002138_abnormal_hepatobiliary_system1.73983159
45MP0001986_abnormal_taste_sensitivity1.73682198
46MP0000778_abnormal_nervous_system1.71687728
47MP0001984_abnormal_olfaction1.70894786
48MP0002168_other_aberrant_phenotype1.64675802
49MP0005075_abnormal_melanosome_morpholog1.59888539
50MP0002938_white_spotting1.49485532
51MP0003705_abnormal_hypodermis_morpholog1.48337160
52MP0003646_muscle_fatigue1.45830508
53MP0003195_calcinosis1.45191739
54MP0000955_abnormal_spinal_cord1.43384998
55MP0010386_abnormal_urinary_bladder1.42465709
56MP0008569_lethality_at_weaning1.42350003
57MP0002066_abnormal_motor_capabilities/c1.40376150
58MP0002876_abnormal_thyroid_physiology1.38664404
59MP0002882_abnormal_neuron_morphology1.34281556
60MP0004811_abnormal_neuron_physiology1.32296969
61MP0003121_genomic_imprinting1.31675276
62MP0008877_abnormal_DNA_methylation1.31121901
63MP0003329_amyloid_beta_deposits1.29847434
64MP0001905_abnormal_dopamine_level1.29149352
65MP0002160_abnormal_reproductive_system1.28353690
66MP0000751_myopathy1.26950922
67MP0005551_abnormal_eye_electrophysiolog1.26304410
68MP0010352_gastrointestinal_tract_polyps1.25696243
69MP0006072_abnormal_retinal_apoptosis1.23884521
70MP0003123_paternal_imprinting1.19980628
71MP0005365_abnormal_bile_salt1.14209011
72MP0002909_abnormal_adrenal_gland1.12556613
73MP0001502_abnormal_circadian_rhythm1.12259066
74MP0000013_abnormal_adipose_tissue1.10086625
75MP0002095_abnormal_skin_pigmentation1.07634593
76MP0002332_abnormal_exercise_endurance1.07291357
77MP0001188_hyperpigmentation1.06342509
78MP0002152_abnormal_brain_morphology1.05151182
79MP0003879_abnormal_hair_cell1.04814451
80MP0004145_abnormal_muscle_electrophysio1.03472674
81MP0004043_abnormal_pH_regulation1.02468536
82MP0000631_abnormal_neuroendocrine_gland1.01524336
83MP0004233_abnormal_muscle_weight0.94914938
84MP0009780_abnormal_chondrocyte_physiolo0.94367810
85MP0000427_abnormal_hair_cycle0.93414818
86MP0002075_abnormal_coat/hair_pigmentati0.92802756
87MP0002069_abnormal_eating/drinking_beha0.92349472
88MP0001963_abnormal_hearing_physiology0.90995169
89MP0002229_neurodegeneration0.90839088
90MP0005395_other_phenotype0.90532438
91MP0002102_abnormal_ear_morphology0.89414158
92MP0004885_abnormal_endolymph0.89309562
93MP0004858_abnormal_nervous_system0.89242927
94MP0005330_cardiomyopathy0.88764222
95MP0001177_atelectasis0.87904143
96MP0002752_abnormal_somatic_nervous0.87561573
97MP0004085_abnormal_heartbeat0.86536416
98MP0004742_abnormal_vestibular_system0.85211768
99MP0004215_abnormal_myocardial_fiber0.84648646
100MP0005174_abnormal_tail_pigmentation0.83978684
101MP0008872_abnormal_physiological_respon0.76191710
102MP0005535_abnormal_body_temperature0.75394168
103MP0003633_abnormal_nervous_system0.75205384
104MP0001299_abnormal_eye_distance/0.74573543
105MP0004484_altered_response_of0.74296284
106MP0002269_muscular_atrophy0.72487648
107MP0001943_abnormal_respiration0.71287393
108MP0003631_nervous_system_phenotype0.70976772
109MP0002638_abnormal_pupillary_reflex0.70581736
110MP0002163_abnormal_gland_morphology0.70038358
111MP0003137_abnormal_impulse_conducting0.69901311
112MP0008789_abnormal_olfactory_epithelium0.67092725
113MP0005187_abnormal_penis_morphology0.66753914
114MP0008874_decreased_physiological_sensi0.66737534
115MP0002090_abnormal_vision0.65294858
116MP0002653_abnormal_ependyma_morphology0.64631772
117MP0000026_abnormal_inner_ear0.64164840
118MP0004130_abnormal_muscle_cell0.63592347
119MP0005171_absent_coat_pigmentation0.62586077
120MP0001186_pigmentation_phenotype0.60526394
121MP0006035_abnormal_mitochondrial_morpho0.58267125
122MP0000639_abnormal_adrenal_gland0.57580373
123MP0003634_abnormal_glial_cell0.57249972
124MP0004036_abnormal_muscle_relaxation0.57015450
125MP0000604_amyloidosis0.56102182
126MP0005389_reproductive_system_phenotype0.55417233
127MP0000015_abnormal_ear_pigmentation0.55413252
128MP0005379_endocrine/exocrine_gland_phen0.55367267
129MP0005499_abnormal_olfactory_system0.55145891
130MP0005394_taste/olfaction_phenotype0.55145891
131MP0005253_abnormal_eye_physiology0.55091143
132MP0003632_abnormal_nervous_system0.52944803
133MP0008770_decreased_survivor_rate0.50315866
134MP0001324_abnormal_eye_pigmentation0.49433798
135MP0000534_abnormal_ureter_morphology0.48291166
136MP0003252_abnormal_bile_duct0.46441279
137MP0009764_decreased_sensitivity_to0.44020484
138MP0005377_hearing/vestibular/ear_phenot0.42222900
139MP0003878_abnormal_ear_physiology0.42222900
140MP0002751_abnormal_autonomic_nervous0.41739417
141MP0005410_abnormal_fertilization0.41346994

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.87811473
2Amelogenesis imperfecta (HP:0000705)8.51118955
3Atonic seizures (HP:0010819)6.75967876
4Acanthocytosis (HP:0001927)6.29160526
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.28145118
6Parakeratosis (HP:0001036)5.93055702
7Febrile seizures (HP:0002373)5.87458344
8Focal seizures (HP:0007359)5.86424878
9Myokymia (HP:0002411)5.27162410
10Absence seizures (HP:0002121)4.97398478
11Colon cancer (HP:0003003)4.76984570
12Dialeptic seizures (HP:0011146)4.59588669
13Epileptic encephalopathy (HP:0200134)4.54851688
14Aplastic anemia (HP:0001915)4.52329335
15Rectal prolapse (HP:0002035)4.39683377
16Generalized tonic-clonic seizures (HP:0002069)4.21233451
17Hematochezia (HP:0002573)4.18637835
18Proximal amyotrophy (HP:0007126)3.98301571
19Vertebral arch anomaly (HP:0008438)3.94247178
20Progressive inability to walk (HP:0002505)3.93327757
21Progressive cerebellar ataxia (HP:0002073)3.89340466
22Visual hallucinations (HP:0002367)3.85402470
23Spontaneous hematomas (HP:0007420)3.80619019
24Hyperventilation (HP:0002883)3.79307230
25Pendular nystagmus (HP:0012043)3.76581973
26Abnormality of aromatic amino acid family metabolism (HP:0004338)3.74491348
27Pancreatic cysts (HP:0001737)3.68487512
28Difficulty walking (HP:0002355)3.38329296
29Congenital ichthyosiform erythroderma (HP:0007431)3.36706994
30Aplasia/Hypoplasia of the uvula (HP:0010293)3.34143255
31Ulnar claw (HP:0001178)3.24256434
32Erythroderma (HP:0001019)3.12696354
33Scapular winging (HP:0003691)3.09844669
34Conjunctival telangiectasia (HP:0000524)3.06142113
35Acute necrotizing encephalopathy (HP:0006965)2.98515950
36Abnormal eating behavior (HP:0100738)2.97675277
37Broad-based gait (HP:0002136)2.96608687
38Polyphagia (HP:0002591)2.95664686
39Dysdiadochokinesis (HP:0002075)2.89783826
40Overlapping toe (HP:0001845)2.89695342
41Abnormal mitochondria in muscle tissue (HP:0008316)2.87915363
42Gaze-evoked nystagmus (HP:0000640)2.83136091
43Abnormality of the renal cortex (HP:0011035)2.82941717
44Poikilocytosis (HP:0004447)2.81149062
45Potter facies (HP:0002009)2.78685889
46Facial shape deformation (HP:0011334)2.78685889
47Broad ribs (HP:0000885)2.76815204
48Status epilepticus (HP:0002133)2.65398241
49Hypoplastic iliac wings (HP:0002866)2.65362973
50Progressive macrocephaly (HP:0004481)2.65228894
51Gait imbalance (HP:0002141)2.63951672
52Termporal pattern (HP:0011008)2.63391959
53Insidious onset (HP:0003587)2.63391959
54Neuroendocrine neoplasm (HP:0100634)2.60766263
55Truncal ataxia (HP:0002078)2.57772225
56Generalized myoclonic seizures (HP:0002123)2.57303639
57Limb dystonia (HP:0002451)2.55552151
58Supranuclear gaze palsy (HP:0000605)2.54830114
59Esophageal varix (HP:0002040)2.54485176
60Drooling (HP:0002307)2.53223914
61Excessive salivation (HP:0003781)2.53223914
62Fetal akinesia sequence (HP:0001989)2.52826900
63Decreased circulating renin level (HP:0003351)2.51631995
64Poor eye contact (HP:0000817)2.51023986
65Impaired social interactions (HP:0000735)2.50797159
66Abnormal social behavior (HP:0012433)2.50797159
67Pheochromocytoma (HP:0002666)2.47461850
68Mutism (HP:0002300)2.47321515
69Hypokalemia (HP:0002900)2.46628210
70Abnormality of binocular vision (HP:0011514)2.43815868
71Diplopia (HP:0000651)2.43815868
72Anxiety (HP:0000739)2.43230828
73Abnormality of the corticospinal tract (HP:0002492)2.41111504
74Inability to walk (HP:0002540)2.40094410
75Abnormality of the vasculature of the conjunctiva (HP:0008054)2.38675387
76Bilateral sensorineural hearing impairment (HP:0008619)2.36721210
77Cerebellar dysplasia (HP:0007033)2.36631687
78Peripheral hypomyelination (HP:0007182)2.35192306
79Epileptiform EEG discharges (HP:0011182)2.34826221
80Hyperthyroidism (HP:0000836)2.34320564
81Abnormality of the renal medulla (HP:0100957)2.34303390
82Dysmetria (HP:0001310)2.34289751
83Abnormality of the labia minora (HP:0012880)2.32183220
84EEG with generalized epileptiform discharges (HP:0011198)2.31946725
85Acute encephalopathy (HP:0006846)2.30344592
86Type II lissencephaly (HP:0007260)2.29223162
87Urinary bladder sphincter dysfunction (HP:0002839)2.28978622
88Radial bowing (HP:0002986)2.28440885
89Action tremor (HP:0002345)2.27835466
90Congenital primary aphakia (HP:0007707)2.27301520
91Portal hypertension (HP:0001409)2.26431639
92Ulnar bowing (HP:0003031)2.24821415
93Abnormal hair whorl (HP:0010721)2.24224527
94Enlarged kidneys (HP:0000105)2.22935348
95Hypsarrhythmia (HP:0002521)2.21792800
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.20464423
97Mitochondrial inheritance (HP:0001427)2.20159393
98Impaired vibration sensation in the lower limbs (HP:0002166)2.19538817
99Retinitis pigmentosa (HP:0000510)2.19235676
100Postural instability (HP:0002172)2.18971847
101Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18564148
102Hemiparesis (HP:0001269)2.18472196
103Medial flaring of the eyebrow (HP:0010747)2.16301837
104Depression (HP:0000716)2.14807694
105Genetic anticipation (HP:0003743)2.13185416
106Absent speech (HP:0001344)2.12692891
107Nephronophthisis (HP:0000090)2.12478553
108Truncus arteriosus (HP:0001660)2.11652141
109Degeneration of the lateral corticospinal tracts (HP:0002314)2.09267837
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09267837
111Abnormality of potassium homeostasis (HP:0011042)2.08978893
112Poor suck (HP:0002033)2.07523755
113Abolished electroretinogram (ERG) (HP:0000550)2.05257886
114Bradykinesia (HP:0002067)2.05209199
115Cystic liver disease (HP:0006706)2.04295320
116Ventricular fibrillation (HP:0001663)2.04280681
117Abnormality of the hepatic vasculature (HP:0006707)2.03278356
118Visceral angiomatosis (HP:0100761)2.03140749
119Syncope (HP:0001279)2.03087251
120Failure to thrive in infancy (HP:0001531)2.00667567
121Amblyopia (HP:0000646)1.99900729
122Torticollis (HP:0000473)1.99060808
123Specific learning disability (HP:0001328)1.98840652
124Narrow nasal bridge (HP:0000446)1.98529354
125Abnormal ciliary motility (HP:0012262)1.97867137
126Genital tract atresia (HP:0001827)1.97786089
127Focal dystonia (HP:0004373)1.97006808
128Nephrogenic diabetes insipidus (HP:0009806)1.96890146
129Abnormality of macular pigmentation (HP:0008002)1.96845779
130Abnormality of salivation (HP:0100755)1.96519915
131Neurofibrillary tangles (HP:0002185)1.95236535
132Synostosis of carpal bones (HP:0005048)1.93138357
133Abnormal albumin level (HP:0012116)1.93020490
134Hypoalbuminemia (HP:0003073)1.93020490
135Bony spicule pigmentary retinopathy (HP:0007737)1.92878077
1362-3 toe syndactyly (HP:0004691)1.92714109
137Increased corneal curvature (HP:0100692)1.91513547
138Keratoconus (HP:0000563)1.91513547
139Agitation (HP:0000713)1.91439540
140Tarsal synostosis (HP:0008368)1.90312606
141Spastic gait (HP:0002064)1.90110409
142Absent/shortened dynein arms (HP:0200106)1.90010044
143Dynein arm defect of respiratory motile cilia (HP:0012255)1.90010044
144Esotropia (HP:0000565)1.89509700
145Abnormality of the shoulder girdle musculature (HP:0001435)1.89181198
146Abnormal respiratory motile cilium physiology (HP:0012261)1.88597679
147Vaginal atresia (HP:0000148)1.88236129
148Hypoventilation (HP:0002791)1.87885632
149Congenital stationary night blindness (HP:0007642)1.87293983
150Increased CSF lactate (HP:0002490)1.87258890
151Hemangiomatosis (HP:0007461)1.87172661
152Abnormality of the vocal cords (HP:0008777)1.86322985
153Ankle clonus (HP:0011448)1.85828339
154Chronic hepatic failure (HP:0100626)1.81530716
155Tubulointerstitial fibrosis (HP:0005576)1.79110398
156Synostosis involving bones of the lower limbs (HP:0009138)1.78975177
157Synostosis involving bones of the feet (HP:0009140)1.78975177
158Tubular atrophy (HP:0000092)1.78840823
159Neuronal loss in central nervous system (HP:0002529)1.78393696
160Urinary urgency (HP:0000012)1.78346740
161Adactyly (HP:0009776)1.78311119
162Spastic tetraplegia (HP:0002510)1.77400611
163Abnormal protein glycosylation (HP:0012346)1.77230831
164Abnormal glycosylation (HP:0012345)1.77230831
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77230831
166Abnormal protein N-linked glycosylation (HP:0012347)1.77230831
167Neoplasm of the small intestine (HP:0100833)1.76861152
168Humeroradial synostosis (HP:0003041)1.75519314
169Synostosis involving the elbow (HP:0003938)1.75519314
170Sporadic (HP:0003745)1.75445425
171Hemiplegia (HP:0002301)1.74751302
172Psychosis (HP:0000709)1.74658944
173Severe visual impairment (HP:0001141)1.74510904
174Postural tremor (HP:0002174)1.74459843
175Chorioretinal atrophy (HP:0000533)1.74254926
176Lipoatrophy (HP:0100578)1.74236645
177Congenital hepatic fibrosis (HP:0002612)1.74146433
178Pancreatic fibrosis (HP:0100732)1.73096346
179Albinism (HP:0001022)1.71037271
180Gangrene (HP:0100758)1.70929227
181Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69496384
182Thickened calvaria (HP:0002684)1.68511558
183Vitreoretinal degeneration (HP:0000655)1.66877215
184Opisthotonus (HP:0002179)1.66602919
185Macular degeneration (HP:0000608)1.65197364
186Neoplasm of the adrenal cortex (HP:0100641)1.64926646
187Palmoplantar keratoderma (HP:0000982)1.63767640
188Dehydration (HP:0001944)1.63680293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L7.17468432
2NTRK34.44388122
3MAP3K43.76168982
4MAP3K93.69054152
5MARK13.68348519
6MAP3K123.63216226
7MAP2K73.45530741
8NLK2.66995120
9ZAK2.65346199
10FRK2.64570123
11CASK2.63512538
12MAP2K42.52445929
13ACVR1B2.51662470
14MINK12.47583774
15MAP2K22.17536384
16NTRK22.16302170
17KSR22.10765624
18LATS110.1868568
19MELK1.98277440
20PNCK1.97976482
21STK31.96756741
22ARAF1.95353424
23ERBB41.86160436
24TNIK1.83227578
25EPHA41.83143022
26NTRK11.73798592
27KSR11.71615416
28LATS21.65838490
29MAP3K61.55441044
30PAK61.52893540
31FES1.45591175
32MAPK131.44658527
33ADRBK21.41765472
34BMPR21.29503552
35PLK21.29484757
36CDK51.22718093
37ERBB31.22569441
38SIK21.20155681
39TAF11.18964748
40MUSK1.13552963
41GRK51.13173112
42CAMK2A1.13099690
43RAF11.11113816
44BCR1.04920434
45NME11.04917208
46MAP3K131.02875514
47PRPF4B0.99267402
48TYRO30.99267186
49PRKAA20.98261462
50PRKCG0.98149871
51CDK80.97685923
52PRKD30.96906950
53CSNK1A1L0.95770394
54CCNB10.95110487
55GRK70.94821793
56PDPK10.93322132
57BRAF0.92179228
58STK380.90115617
59PRKCE0.88620611
60UHMK10.88154294
61NEK20.87518153
62DAPK10.85831794
63DYRK20.84125139
64DAPK20.79394794
65TGFBR10.79308176
66CSNK1G20.78860936
67STK110.78705452
68TNK20.76209697
69PAK30.75928058
70CAMKK10.74329600
71MOS0.72612331
72ADRBK10.72501087
73RET0.72305097
74PHKG10.72212597
75PHKG20.72212597
76PIK3CG0.70824294
77MAP3K10.68946430
78FER0.65969836
79AKT30.63991521
80DYRK1A0.63109906
81SGK4940.61300301
82SGK2230.61300301
83OXSR10.61085748
84CDK140.61031230
85CDK180.60769708
86PRKD10.60257275
87MAP3K20.57010653
88CAMK2B0.56446624
89EIF2AK30.56220509
90PRKCH0.55980452
91SIK30.55816676
92CDK150.55500302
93WNK30.53637951
94PRKCZ0.53109362
95SGK20.51414358
96BMPR1B0.50629113
97VRK10.50009841
98CAMK2G0.48799260
99SGK10.48075007
100PINK10.48060692
101CSNK1G30.47612382
102LIMK10.46138798
103MAP2K10.46027026
104ROCK20.45683454
105PDK30.44991321
106PDK40.44991321
107RIPK40.44246625
108WNK40.43905264
109FGR0.43585796
110RPS6KA30.42684612
111PRKACA0.42324667
112CDK11A0.42219085
113STK390.41387516
114CDK30.40721885
115PDGFRA0.40716242
116TAOK10.39112500
117CAMK2D0.38943339
118CAMK10.38570856
119CSNK1E0.38489451
120IRAK30.37548668
121CDK190.37128432
122TSSK60.36436738
123PRKG10.36119300
124TGFBR20.33705654
125NUAK10.30431317
126CSNK1D0.28440564
127MAP3K70.23193423
128TAOK30.22545097
129NEK90.18320376
130GRK10.17158271
131MAPKAPK50.16408155
132MAP4K20.15957663
133TTK0.14920788
134PRKCI0.14736865
135PLK10.14372666
136PIM10.14157964
137CAMKK20.07653977
138ABL10.07573653
139TRIM280.07328686
140MAPK30.07120113
141CSNK1G10.07018255
142PRKACB0.06429964
143AKT20.06223137
144CHEK20.06156597
145CSNK1A10.02976359
146EIF2AK20.02487001
147MAPK80.02140226
148PDK10.01709782
149MAPK10.01472248
150INSRR0.01418871

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.23206782
2Synaptic vesicle cycle_Homo sapiens_hsa047213.62969630
3GABAergic synapse_Homo sapiens_hsa047273.23676640
4Sphingolipid metabolism_Homo sapiens_hsa006003.12488481
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.97558239
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92475473
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.90257569
8Oxidative phosphorylation_Homo sapiens_hsa001902.48341417
9Morphine addiction_Homo sapiens_hsa050322.45658609
10Collecting duct acid secretion_Homo sapiens_hsa049662.38300568
11Olfactory transduction_Homo sapiens_hsa047402.28740742
12Circadian entrainment_Homo sapiens_hsa047132.24271315
13Glutamatergic synapse_Homo sapiens_hsa047242.23411929
14Long-term potentiation_Homo sapiens_hsa047202.12111783
15Serotonergic synapse_Homo sapiens_hsa047262.00261638
16Taste transduction_Homo sapiens_hsa047421.98549015
17Dopaminergic synapse_Homo sapiens_hsa047281.88735463
18Amphetamine addiction_Homo sapiens_hsa050311.88132203
19Parkinsons disease_Homo sapiens_hsa050121.81773585
20Insulin secretion_Homo sapiens_hsa049111.75160145
21Phenylalanine metabolism_Homo sapiens_hsa003601.70601589
22Salivary secretion_Homo sapiens_hsa049701.68411017
23Alzheimers disease_Homo sapiens_hsa050101.62150419
24Cholinergic synapse_Homo sapiens_hsa047251.60502725
25Cardiac muscle contraction_Homo sapiens_hsa042601.58695061
26Long-term depression_Homo sapiens_hsa047301.56595542
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55780589
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55354880
29N-Glycan biosynthesis_Homo sapiens_hsa005101.54427763
30Cocaine addiction_Homo sapiens_hsa050301.53729010
31Renin secretion_Homo sapiens_hsa049241.44557042
32Vibrio cholerae infection_Homo sapiens_hsa051101.42253070
33Butanoate metabolism_Homo sapiens_hsa006501.38776687
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38575678
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36814152
36Gastric acid secretion_Homo sapiens_hsa049711.35983333
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34205680
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33692780
39Huntingtons disease_Homo sapiens_hsa050161.32652679
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28312872
41GnRH signaling pathway_Homo sapiens_hsa049121.28136385
42Type I diabetes mellitus_Homo sapiens_hsa049401.27655314
43Oxytocin signaling pathway_Homo sapiens_hsa049211.27200319
44Dorso-ventral axis formation_Homo sapiens_hsa043201.24342983
45Phototransduction_Homo sapiens_hsa047441.24245143
46Calcium signaling pathway_Homo sapiens_hsa040201.23551838
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21036860
48Histidine metabolism_Homo sapiens_hsa003401.16416428
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13591912
50One carbon pool by folate_Homo sapiens_hsa006701.13254590
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.07358484
52Tryptophan metabolism_Homo sapiens_hsa003801.06598684
53Nitrogen metabolism_Homo sapiens_hsa009101.05679371
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05455272
55Gap junction_Homo sapiens_hsa045401.04991679
56Axon guidance_Homo sapiens_hsa043601.04926606
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04791393
58Estrogen signaling pathway_Homo sapiens_hsa049150.99755361
59Folate biosynthesis_Homo sapiens_hsa007900.99164213
60cAMP signaling pathway_Homo sapiens_hsa040240.97702001
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95926682
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95662484
63Ovarian steroidogenesis_Homo sapiens_hsa049130.88832492
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85592187
65ErbB signaling pathway_Homo sapiens_hsa040120.84734092
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.81639357
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80714131
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80458595
69ABC transporters_Homo sapiens_hsa020100.79032959
70Melanogenesis_Homo sapiens_hsa049160.78355229
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.78237292
72Oocyte meiosis_Homo sapiens_hsa041140.76551988
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73605803
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.71869729
75Type II diabetes mellitus_Homo sapiens_hsa049300.70443702
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69364632
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.69098537
78Dilated cardiomyopathy_Homo sapiens_hsa054140.68337600
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68315713
80Tyrosine metabolism_Homo sapiens_hsa003500.68000238
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66484431
82Rheumatoid arthritis_Homo sapiens_hsa053230.66396718
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64774207
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64460770
85Ras signaling pathway_Homo sapiens_hsa040140.64214812
86VEGF signaling pathway_Homo sapiens_hsa043700.61984470
87MAPK signaling pathway_Homo sapiens_hsa040100.61590889
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58943299
89Glioma_Homo sapiens_hsa052140.57089419
90Thyroid hormone synthesis_Homo sapiens_hsa049180.56232922
91Basal transcription factors_Homo sapiens_hsa030220.55044637
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54310123
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.54226641
94Choline metabolism in cancer_Homo sapiens_hsa052310.53879162
95Glycerolipid metabolism_Homo sapiens_hsa005610.52357430
96Pyruvate metabolism_Homo sapiens_hsa006200.49118327
97Vitamin digestion and absorption_Homo sapiens_hsa049770.48455795
98Glucagon signaling pathway_Homo sapiens_hsa049220.47496170
99Hippo signaling pathway_Homo sapiens_hsa043900.47131373
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45743562
101Ether lipid metabolism_Homo sapiens_hsa005650.42998417
102Prion diseases_Homo sapiens_hsa050200.42988980
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41419911
104Linoleic acid metabolism_Homo sapiens_hsa005910.40936965
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40347824
106Melanoma_Homo sapiens_hsa052180.40238727
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39940044
108Pancreatic secretion_Homo sapiens_hsa049720.39079913
109Alcoholism_Homo sapiens_hsa050340.37516801
110Viral myocarditis_Homo sapiens_hsa054160.37458424
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36473081
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36236919
113Rap1 signaling pathway_Homo sapiens_hsa040150.35398745
114Bile secretion_Homo sapiens_hsa049760.33779089
115Circadian rhythm_Homo sapiens_hsa047100.32730258
116TGF-beta signaling pathway_Homo sapiens_hsa043500.31991417
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31847817
118Adherens junction_Homo sapiens_hsa045200.30902040
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30374384
120Renal cell carcinoma_Homo sapiens_hsa052110.30159679
121Wnt signaling pathway_Homo sapiens_hsa043100.29706618
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29464743
123Phagosome_Homo sapiens_hsa041450.29401164
124Chemical carcinogenesis_Homo sapiens_hsa052040.28888957
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28267219
126Colorectal cancer_Homo sapiens_hsa052100.27823957
127Arginine biosynthesis_Homo sapiens_hsa002200.27595245
128Retinol metabolism_Homo sapiens_hsa008300.27438137
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25968130
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24339030
131Inositol phosphate metabolism_Homo sapiens_hsa005620.24197001
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24063270
133Arginine and proline metabolism_Homo sapiens_hsa003300.22798829
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.22663308
135ECM-receptor interaction_Homo sapiens_hsa045120.18730665
136beta-Alanine metabolism_Homo sapiens_hsa004100.18571614
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18123286
138Vitamin B6 metabolism_Homo sapiens_hsa007500.17789860
139Lysine degradation_Homo sapiens_hsa003100.17685588
140Fatty acid degradation_Homo sapiens_hsa000710.14550627
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14371173

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