VWC2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.24112743
2vocalization behavior (GO:0071625)5.49207053
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.43370170
4pyrimidine nucleobase catabolic process (GO:0006208)5.33072999
5synaptic vesicle exocytosis (GO:0016079)5.30940488
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.95222697
7dopamine transport (GO:0015872)4.69204936
8neurotransmitter secretion (GO:0007269)4.60379381
9regulation of synaptic vesicle exocytosis (GO:2000300)4.57918905
10glutamate secretion (GO:0014047)4.52664055
11establishment of mitochondrion localization (GO:0051654)4.51601081
12response to histamine (GO:0034776)4.48368005
13startle response (GO:0001964)4.47618209
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.45402189
15regulation of glutamate receptor signaling pathway (GO:1900449)4.44348478
16neurotransmitter biosynthetic process (GO:0042136)4.36214805
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.34127472
18catecholamine transport (GO:0051937)4.33540118
19locomotory exploration behavior (GO:0035641)4.30833566
20nucleobase catabolic process (GO:0046113)4.30595599
21dopamine biosynthetic process (GO:0042416)4.15224074
22presynaptic membrane assembly (GO:0097105)4.14691057
23neurofilament cytoskeleton organization (GO:0060052)4.14687064
24regulation of respiratory system process (GO:0044065)4.13478170
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.05416945
26neuron-neuron synaptic transmission (GO:0007270)4.03404657
27neurotransmitter transport (GO:0006836)4.01211210
28regulation of synaptic vesicle transport (GO:1902803)3.97613826
29positive regulation of synapse assembly (GO:0051965)3.96384137
30proline transport (GO:0015824)3.96259115
31protein localization to synapse (GO:0035418)3.93545173
32protein localization to cilium (GO:0061512)3.90821640
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.86480295
34synaptic vesicle maturation (GO:0016188)3.84189125
35neuron recognition (GO:0008038)3.83352066
36regulation of neurotransmitter levels (GO:0001505)3.82540068
37mating behavior (GO:0007617)3.81638548
38exploration behavior (GO:0035640)3.80249485
39positive regulation of amino acid transport (GO:0051957)3.80127453
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78275070
41presynaptic membrane organization (GO:0097090)3.78055492
42cellular response to ammonium ion (GO:0071242)3.77968109
43neurotransmitter-gated ion channel clustering (GO:0072578)3.76804206
44postsynaptic membrane organization (GO:0001941)3.76143053
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.74489455
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.73579749
47C4-dicarboxylate transport (GO:0015740)3.72623496
48membrane depolarization during action potential (GO:0086010)3.69188436
49negative regulation of neurotransmitter transport (GO:0051589)3.61141655
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.59306561
51opioid receptor signaling pathway (GO:0038003)3.58085255
52energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.56530115
53ATP hydrolysis coupled proton transport (GO:0015991)3.56530115
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.56028881
55synaptic transmission, dopaminergic (GO:0001963)3.55530169
56synaptic transmission, glutamatergic (GO:0035249)3.55257475
57neuronal action potential propagation (GO:0019227)3.55151671
58glutamate receptor signaling pathway (GO:0007215)3.49713814
59response to cocaine (GO:0042220)3.48263311
60prepulse inhibition (GO:0060134)3.44682072
61adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.43824772
62regulation of glutamate secretion (GO:0014048)3.42466749
63neuronal action potential (GO:0019228)3.42409300
64neurotransmitter metabolic process (GO:0042133)3.42068817
65retinal cone cell development (GO:0046549)3.40972659
66gamma-aminobutyric acid transport (GO:0015812)3.38945556
67synapse assembly (GO:0007416)3.38497712
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36447826
69negative regulation of dendrite morphogenesis (GO:0050774)3.35935695
70regulation of vesicle fusion (GO:0031338)3.35723056
71sodium ion export (GO:0071436)3.29803472
72neurotransmitter catabolic process (GO:0042135)3.29531817
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28798657
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.28648453
75regulation of respiratory gaseous exchange (GO:0043576)3.25164953
76regulation of long-term neuronal synaptic plasticity (GO:0048169)3.23301697
77regulation of penile erection (GO:0060405)3.22735104
78adult walking behavior (GO:0007628)3.21716878
79synaptic vesicle endocytosis (GO:0048488)3.20465602
80glycosphingolipid biosynthetic process (GO:0006688)3.19848856
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19801757
82long-term synaptic potentiation (GO:0060291)3.19572731
83transferrin transport (GO:0033572)3.19519281
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.17609753
85activation of protein kinase A activity (GO:0034199)3.17213739
86regulation of synapse structural plasticity (GO:0051823)3.13696188
87behavioral response to cocaine (GO:0048148)3.12347627
88regulation of synapse assembly (GO:0051963)3.11945058
89L-amino acid import (GO:0043092)3.11144448
90membrane depolarization (GO:0051899)3.08882141
91regulation of cAMP-dependent protein kinase activity (GO:2000479)3.06336569
92regulation of neurotransmitter secretion (GO:0046928)3.05843612
93axonal fasciculation (GO:0007413)3.04964736
94establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.04056397
95mitochondrion transport along microtubule (GO:0047497)3.04056397
96regulation of excitatory postsynaptic membrane potential (GO:0060079)3.03976153
97regulation of neuronal synaptic plasticity (GO:0048168)3.02240571
98regulation of neurotransmitter transport (GO:0051588)3.00853541
99negative regulation of synaptic transmission (GO:0050805)3.00753472
100synaptic vesicle transport (GO:0048489)3.00144844
101establishment of synaptic vesicle localization (GO:0097480)3.00144844
102establishment of vesicle localization (GO:0051650)3.00032243
103regulation of postsynaptic membrane potential (GO:0060078)2.99858895
104dendrite development (GO:0016358)2.99217155
105cell migration in hindbrain (GO:0021535)2.99108407
106layer formation in cerebral cortex (GO:0021819)2.98829065
107trivalent inorganic cation transport (GO:0072512)2.98380950
108ferric iron transport (GO:0015682)2.98380950
109synaptic transmission (GO:0007268)2.98023767
110regulation of catecholamine metabolic process (GO:0042069)2.97954699
111regulation of dopamine metabolic process (GO:0042053)2.97954699
112sialylation (GO:0097503)2.97430472
113regulation of synaptic transmission, GABAergic (GO:0032228)2.97015896
114adult behavior (GO:0030534)2.96719957
115transmission of nerve impulse (GO:0019226)2.96501268
116cellular potassium ion homeostasis (GO:0030007)2.95800437
117response to insecticide (GO:0017085)2.95475067
118multi-organism reproductive behavior (GO:0044705)2.94670491
119negative regulation of dendrite development (GO:2000171)2.93852640
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93811866
121phenol-containing compound catabolic process (GO:0019336)2.93415656
122synapse organization (GO:0050808)2.93105902
123positive regulation of potassium ion transmembrane transport (GO:1901381)2.92983483
124dendritic spine morphogenesis (GO:0060997)2.92764984
125membrane hyperpolarization (GO:0060081)2.92012538
126positive regulation of neurotransmitter transport (GO:0051590)2.91625868
127positive regulation of synapse maturation (GO:0090129)2.90640825
128positive regulation of action potential (GO:0045760)2.90394498
129negative regulation of microtubule polymerization (GO:0031115)2.90066632
130regulation of action potential (GO:0098900)2.87465536
131dendrite morphogenesis (GO:0048813)2.84592719
132regulation of dopamine secretion (GO:0014059)2.84105342
133amino acid import (GO:0043090)2.82506105
134adult locomotory behavior (GO:0008344)2.82276612
135neuromuscular synaptic transmission (GO:0007274)2.79999318
136positive regulation of vesicle fusion (GO:0031340)2.77636868
137positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.77000784
138positive regulation of amine transport (GO:0051954)2.75617261
139regulation of dendritic spine morphogenesis (GO:0061001)2.72430939
140regulation of feeding behavior (GO:0060259)2.69983632
141neuronal ion channel clustering (GO:0045161)2.68881558
142cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.66136546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.69579059
2GBX2_23144817_ChIP-Seq_PC3_Human4.58538464
3TAF15_26573619_Chip-Seq_HEK293_Human3.46769869
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.20807955
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05702820
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00672205
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88831643
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57998128
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.57481161
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47328580
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44432164
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42958196
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39987868
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39987868
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.39242171
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.37968873
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35868048
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29841586
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.28524303
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.26813856
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24217815
22* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23765600
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21593949
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11445475
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08872862
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00946584
27P300_19829295_ChIP-Seq_ESCs_Human1.96261051
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.95128704
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.94981086
30IGF1R_20145208_ChIP-Seq_DFB_Human1.93186628
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88961285
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.87332718
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87029622
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82590394
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.81838894
36FUS_26573619_Chip-Seq_HEK293_Human1.73148854
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72913735
38DROSHA_22980978_ChIP-Seq_HELA_Human1.72320582
39AR_21572438_ChIP-Seq_LNCaP_Human1.70548696
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.65771480
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65537030
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.65227775
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63920046
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58609656
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.57576213
46RNF2_27304074_Chip-Seq_NSC_Mouse1.53588079
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51535110
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.49756302
49ER_23166858_ChIP-Seq_MCF-7_Human1.48265810
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48248003
51* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47325104
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.46488250
53ZNF274_21170338_ChIP-Seq_K562_Hela1.46091874
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45995679
55VDR_22108803_ChIP-Seq_LS180_Human1.43268143
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.42646368
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42511518
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42466392
59* AR_25329375_ChIP-Seq_VCAP_Human1.40465298
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35866668
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34373878
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32772361
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.31041632
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25347416
65CBP_20019798_ChIP-Seq_JUKART_Human1.25347416
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24120980
67* STAT3_23295773_ChIP-Seq_U87_Human1.23841704
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23098259
69JUN_21703547_ChIP-Seq_K562_Human1.22095282
70* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20329089
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.19626772
72TCF4_23295773_ChIP-Seq_U87_Human1.19282092
73RUNX2_22187159_ChIP-Seq_PCA_Human1.18208720
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.18136539
75BCAT_22108803_ChIP-Seq_LS180_Human1.17138771
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16653609
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.16274086
78* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14457915
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13994918
80* NANOG_18555785_Chip-Seq_ESCs_Mouse1.11912971
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.10757703
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.09121637
83* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08786441
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07234614
85* P53_22387025_ChIP-Seq_ESCs_Mouse1.07048364
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.06584981
87* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05980495
88* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05750096
89* E2F1_18555785_Chip-Seq_ESCs_Mouse1.05728420
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04875563
91SOX9_26525672_Chip-Seq_HEART_Mouse1.04649645
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04175322
93AR_19668381_ChIP-Seq_PC3_Human1.03688415
94AHR_22903824_ChIP-Seq_MCF-7_Human1.03121383
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02990828
96* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02502234
97* FLI1_27457419_Chip-Seq_LIVER_Mouse1.02457628
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02363106
99* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02141623
100* KDM2B_26808549_Chip-Seq_REH_Human1.01200707
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00613633
102EWS_26573619_Chip-Seq_HEK293_Human1.00568029
103TP53_18474530_ChIP-ChIP_U2OS_Human1.00459240
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99448042
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99284857
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96863635
107* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96329939
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95401912
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95401912
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94564767
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.91509156
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91359544
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91260400
114* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90959537
115* CMYC_18555785_Chip-Seq_ESCs_Mouse0.88989460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.96087934
2MP0004859_abnormal_synaptic_plasticity4.10018838
3MP0003635_abnormal_synaptic_transmissio3.62524945
4MP0009046_muscle_twitch3.40832941
5MP0009745_abnormal_behavioral_response3.37161234
6MP0002822_catalepsy3.17631484
7MP0002064_seizures3.12755550
8MP0006276_abnormal_autonomic_nervous3.11995401
9MP0001968_abnormal_touch/_nociception3.06936233
10MP0002063_abnormal_learning/memory/cond2.91509640
11MP0002572_abnormal_emotion/affect_behav2.84589538
12MP0001529_abnormal_vocalization2.70031714
13MP0004270_analgesia2.69757507
14MP0002735_abnormal_chemical_nociception2.60583550
15MP0002734_abnormal_mechanical_nocicepti2.57893725
16MP0005423_abnormal_somatic_nervous2.54809614
17MP0002272_abnormal_nervous_system2.53217404
18MP0003122_maternal_imprinting2.46263720
19MP0001486_abnormal_startle_reflex2.45531166
20MP0001905_abnormal_dopamine_level2.40735973
21MP0002736_abnormal_nociception_after2.32896304
22MP0001501_abnormal_sleep_pattern2.26019491
23MP0002733_abnormal_thermal_nociception2.19791229
24MP0001188_hyperpigmentation2.17661068
25MP0001440_abnormal_grooming_behavior2.17347124
26MP0002067_abnormal_sensory_capabilities2.10857900
27MP0005386_behavior/neurological_phenoty2.08937518
28MP0004924_abnormal_behavior2.08937518
29MP0001970_abnormal_pain_threshold1.97526344
30MP0002184_abnormal_innervation1.93851132
31MP0009780_abnormal_chondrocyte_physiolo1.83793014
32MP0002557_abnormal_social/conspecific_i1.76256726
33MP0002837_dystrophic_cardiac_calcinosis1.66776281
34MP0000778_abnormal_nervous_system1.66457281
35MP0005646_abnormal_pituitary_gland1.65685816
36MP0004142_abnormal_muscle_tone1.57076374
37MP0001986_abnormal_taste_sensitivity1.55892613
38MP0002909_abnormal_adrenal_gland1.52600802
39MP0005645_abnormal_hypothalamus_physiol1.48706510
40MP0004811_abnormal_neuron_physiology1.48058872
41MP0008872_abnormal_physiological_respon1.46439726
42MP0003879_abnormal_hair_cell1.45064560
43MP0002876_abnormal_thyroid_physiology1.43948817
44MP0002066_abnormal_motor_capabilities/c1.36011137
45MP0008569_lethality_at_weaning1.33374461
46MP0003329_amyloid_beta_deposits1.32347547
47MP0002882_abnormal_neuron_morphology1.31132838
48MP0003183_abnormal_peptide_metabolism1.29587217
49MP0002102_abnormal_ear_morphology1.29515375
50MP0003787_abnormal_imprinting1.29502223
51MP0010386_abnormal_urinary_bladder1.29028896
52MP0001984_abnormal_olfaction1.28786585
53MP0000955_abnormal_spinal_cord1.28051824
54MP0008877_abnormal_DNA_methylation1.23277694
55MP0001502_abnormal_circadian_rhythm1.20218576
56MP0000751_myopathy1.17641352
57MP0005248_abnormal_Harderian_gland1.15309506
58MP0005551_abnormal_eye_electrophysiolog1.13109143
59MP0001485_abnormal_pinna_reflex1.13009597
60MP0002638_abnormal_pupillary_reflex1.09933755
61MP0004858_abnormal_nervous_system1.09530051
62MP0005535_abnormal_body_temperature1.04375542
63MP0004147_increased_porphyrin_level1.03631580
64MP0001664_abnormal_digestion1.03475121
65MP0002751_abnormal_autonomic_nervous0.95845263
66MP0004085_abnormal_heartbeat0.95004773
67MP0005409_darkened_coat_color0.94869517
68MP0008789_abnormal_olfactory_epithelium0.94514161
69MP0008995_early_reproductive_senescence0.94453095
70MP0002069_abnormal_eating/drinking_beha0.92983862
71MP0002152_abnormal_brain_morphology0.92400739
72MP0002229_neurodegeneration0.91961087
73MP0003631_nervous_system_phenotype0.91594002
74MP0003633_abnormal_nervous_system0.90984558
75MP0005187_abnormal_penis_morphology0.90223063
76MP0001963_abnormal_hearing_physiology0.90017494
77MP0000631_abnormal_neuroendocrine_gland0.89796022
78MP0002332_abnormal_exercise_endurance0.88133874
79MP0000013_abnormal_adipose_tissue0.88112843
80MP0008874_decreased_physiological_sensi0.86450966
81MP0000427_abnormal_hair_cycle0.86325776
82MP0000569_abnormal_digit_pigmentation0.85444983
83MP0002752_abnormal_somatic_nervous0.83645243
84MP0003121_genomic_imprinting0.83419701
85MP0004742_abnormal_vestibular_system0.81592278
86MP0003632_abnormal_nervous_system0.80195024
87MP0003646_muscle_fatigue0.80040637
88MP0001177_atelectasis0.79752433
89MP0005499_abnormal_olfactory_system0.79440894
90MP0005394_taste/olfaction_phenotype0.79440894
91MP0002234_abnormal_pharynx_morphology0.79338097
92MP0004885_abnormal_endolymph0.79123538
93MP0003638_abnormal_response/metabolism_0.78884669
94MP0003690_abnormal_glial_cell0.73934690
95MP0002090_abnormal_vision0.72408654
96MP0004233_abnormal_muscle_weight0.71382962
97MP0004215_abnormal_myocardial_fiber0.70991665
98MP0004484_altered_response_of0.70398172
99MP0000920_abnormal_myelination0.69934131
100MP0006072_abnormal_retinal_apoptosis0.69647082
101MP0002160_abnormal_reproductive_system0.68378797
102MP0001943_abnormal_respiration0.66834574
103MP0003698_abnormal_male_reproductive0.65385610
104MP0001299_abnormal_eye_distance/0.64711308
105MP0004043_abnormal_pH_regulation0.64353734
106MP0003634_abnormal_glial_cell0.63011359
107MP0005195_abnormal_posterior_eye0.61847661
108MP0000026_abnormal_inner_ear0.61436253
109MP0000538_abnormal_urinary_bladder0.61132960
110MP0003119_abnormal_digestive_system0.60529965
111MP0003861_abnormal_nervous_system0.59077280
112MP0003283_abnormal_digestive_organ0.58642183
113MP0001270_distended_abdomen0.57938607
114MP0005253_abnormal_eye_physiology0.56512024
115MP0005084_abnormal_gallbladder_morpholo0.55569454
116MP0002082_postnatal_lethality0.55171289
117MP0010770_preweaning_lethality0.55171289
118MP0003123_paternal_imprinting0.54958149
119MP0010769_abnormal_survival0.54680374
120MP0010768_mortality/aging0.53875580
121MP0000604_amyloidosis0.53649525
122MP0005448_abnormal_energy_balance0.52145952

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.69999188
2Limb dystonia (HP:0002451)6.09218265
3Atonic seizures (HP:0010819)5.61432457
4Focal seizures (HP:0007359)5.23918937
5Febrile seizures (HP:0002373)5.16853516
6Epileptic encephalopathy (HP:0200134)4.84487410
7Myokymia (HP:0002411)4.79717322
8Ulnar claw (HP:0001178)4.79673971
9Absence seizures (HP:0002121)4.44355102
10Visual hallucinations (HP:0002367)4.43683836
11Generalized tonic-clonic seizures (HP:0002069)4.17686230
12Hyperventilation (HP:0002883)4.13601966
13Pheochromocytoma (HP:0002666)3.89504458
14Dialeptic seizures (HP:0011146)3.89263318
15Progressive cerebellar ataxia (HP:0002073)3.80764814
16Failure to thrive in infancy (HP:0001531)3.75823119
17Neuroendocrine neoplasm (HP:0100634)3.62589758
18Hypothermia (HP:0002045)3.61735864
19Polyphagia (HP:0002591)3.52809596
20Broad-based gait (HP:0002136)3.48540722
21Truncal ataxia (HP:0002078)3.20604409
22Progressive inability to walk (HP:0002505)3.20593297
23Acute necrotizing encephalopathy (HP:0006965)3.05441990
24Poor suck (HP:0002033)3.03482332
25Hemiparesis (HP:0001269)3.01318714
26Lissencephaly (HP:0001339)2.96781914
27Abnormal eating behavior (HP:0100738)2.91020301
28Abnormal hair whorl (HP:0010721)2.87971827
29Abnormal mitochondria in muscle tissue (HP:0008316)2.87677089
30Progressive macrocephaly (HP:0004481)2.84639414
31Hypoventilation (HP:0002791)2.84475464
32Drooling (HP:0002307)2.78723355
33Excessive salivation (HP:0003781)2.78723355
34Anxiety (HP:0000739)2.76207638
35Gaze-evoked nystagmus (HP:0000640)2.71430651
36Peripheral hypomyelination (HP:0007182)2.67178780
37Fetal akinesia sequence (HP:0001989)2.64872277
38Akinesia (HP:0002304)2.64002688
39Amblyopia (HP:0000646)2.61833719
40Supranuclear gaze palsy (HP:0000605)2.60472141
41Status epilepticus (HP:0002133)2.58300333
42Mutism (HP:0002300)2.57015616
43Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.56732083
44Epileptiform EEG discharges (HP:0011182)2.54916332
45Pachygyria (HP:0001302)2.54836085
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.52072479
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.52072479
48Nephrogenic diabetes insipidus (HP:0009806)2.52035733
49Hypoplasia of the brainstem (HP:0002365)2.50448721
50Aplasia/Hypoplasia of the brainstem (HP:0007362)2.50448721
51Lower limb muscle weakness (HP:0007340)2.50171452
52Depression (HP:0000716)2.50118227
53Oligomenorrhea (HP:0000876)2.49674978
54Agitation (HP:0000713)2.47363207
55Bradykinesia (HP:0002067)2.47104862
56Esotropia (HP:0000565)2.43927529
57Termporal pattern (HP:0011008)2.43194863
58Insidious onset (HP:0003587)2.43194863
59Blue irides (HP:0000635)2.42071683
60Gait imbalance (HP:0002141)2.41607602
61Abnormality of the labia minora (HP:0012880)2.39889472
62EEG with generalized epileptiform discharges (HP:0011198)2.39787130
63Spastic tetraplegia (HP:0002510)2.38592491
64Inability to walk (HP:0002540)2.34553735
65Intestinal atresia (HP:0011100)2.33685922
66Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.33048794
67Dysdiadochokinesis (HP:0002075)2.30254242
68Optic nerve hypoplasia (HP:0000609)2.30091979
69Cerebral inclusion bodies (HP:0100314)2.28956047
70Poor eye contact (HP:0000817)2.26576144
71Retinal dysplasia (HP:0007973)2.26326944
72Impaired vibration sensation in the lower limbs (HP:0002166)2.24805165
73Mitochondrial inheritance (HP:0001427)2.24484308
74Acute encephalopathy (HP:0006846)2.22235534
75Delayed gross motor development (HP:0002194)2.21849603
76Hypsarrhythmia (HP:0002521)2.19722627
77Cortical dysplasia (HP:0002539)2.18537950
78Absent speech (HP:0001344)2.17774305
79Protruding tongue (HP:0010808)2.17722989
80Hyperthyroidism (HP:0000836)2.15648377
81Intention tremor (HP:0002080)2.14987904
82Ankle clonus (HP:0011448)2.14781859
83Resting tremor (HP:0002322)2.14573969
84Abnormal social behavior (HP:0012433)2.14277734
85Impaired social interactions (HP:0000735)2.14277734
86Dyskinesia (HP:0100660)2.13904398
87Papilledema (HP:0001085)2.13760492
88Neoplasm of the peripheral nervous system (HP:0100007)2.13084666
89Narrow nasal bridge (HP:0000446)2.10544707
90Steppage gait (HP:0003376)2.09188936
91Hammertoe (HP:0001765)2.09084930
92Sleep apnea (HP:0010535)2.08880484
93Diplopia (HP:0000651)2.08499423
94Abnormality of binocular vision (HP:0011514)2.08499423
95Dysmetria (HP:0001310)2.06612914
96Generalized myoclonic seizures (HP:0002123)2.05502280
97Impaired pain sensation (HP:0007328)2.05066165
98Abnormality of pain sensation (HP:0010832)2.05066165
99Paraplegia (HP:0010550)2.03652232
100Decreased muscle mass (HP:0003199)2.03581000
101Action tremor (HP:0002345)2.03548552
102Gait ataxia (HP:0002066)2.02943297
103Amyotrophic lateral sclerosis (HP:0007354)2.02694196
104Poor coordination (HP:0002370)2.02494187
105Exotropia (HP:0000577)2.01464350
106Abnormality of the lower motor neuron (HP:0002366)2.01250529
107Urinary urgency (HP:0000012)2.01067580
108Optic disc pallor (HP:0000543)1.99332339
109Torticollis (HP:0000473)1.96860860
110Abnormality of the corticospinal tract (HP:0002492)1.96380373
111Congenital primary aphakia (HP:0007707)1.96073954
112Medial flaring of the eyebrow (HP:0010747)1.96001082
113Abnormality of the vocal cords (HP:0008777)1.95874507
114Urinary bladder sphincter dysfunction (HP:0002839)1.94770664
115Postural instability (HP:0002172)1.94505892
116Spastic gait (HP:0002064)1.94354667
117Postural tremor (HP:0002174)1.93624466
118Rigidity (HP:0002063)1.93398559
119Psychosis (HP:0000709)1.93103109
120Clonus (HP:0002169)1.92884316
121Muscular hypotonia of the trunk (HP:0008936)1.91666395
122Hemiplegia (HP:0002301)1.91617042
123Specific learning disability (HP:0001328)1.91607724
124Diminished movement (HP:0002374)1.91115602
125Genetic anticipation (HP:0003743)1.90517708
126Abnormal ciliary motility (HP:0012262)1.90240000
127Abnormality of salivation (HP:0100755)1.90194806
128Hypoplasia of the corpus callosum (HP:0002079)1.89254428
129Genital tract atresia (HP:0001827)1.88048914
130Vaginal atresia (HP:0000148)1.85621541
131Cerebral hemorrhage (HP:0001342)1.85115667
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84893961
133Gastroesophageal reflux (HP:0002020)1.84715231
134Morphological abnormality of the pyramidal tract (HP:0002062)1.84595631
135Neurofibrillary tangles (HP:0002185)1.84159332
136Spastic paraplegia (HP:0001258)1.83931029
137Abnormal pupillary function (HP:0007686)1.83352015
138Type II lissencephaly (HP:0007260)1.81974080
139Volvulus (HP:0002580)1.73370465
140Pancreatic fibrosis (HP:0100732)1.72703182
141True hermaphroditism (HP:0010459)1.70644988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.59656325
2MAP3K123.84821242
3MAP3K43.26656661
4NTRK33.20922972
5MAP2K73.17883639
6MARK13.17025365
7MAP3K92.81146329
8MINK12.50270840
9ERBB32.39829661
10MAP2K42.26737598
11AKT32.24779973
12EPHA42.20877159
13PLK22.17498882
14GRK52.14211338
15TRIM282.09038866
16NTRK21.88413608
17MAPK131.69545350
18MAP4K21.68231909
19PNCK1.68128725
20MUSK1.62535834
21CSNK1G21.58625802
22PINK11.55824797
23CSNK1G31.53501560
24FRK1.53259799
25TSSK61.46978685
26CDK191.44328686
27ARAF1.41229074
28DAPK21.36002559
29CAMK2A1.35639865
30NTRK11.34824320
31TNIK1.29478555
32DAPK11.29238306
33MAPKAPK51.26685230
34GRK71.24276016
35CDK51.22171103
36PRKCG1.22139795
37ADRBK21.22107352
38LATS21.21625221
39ERBB41.10512208
40RIPK41.10307670
41NME11.09260045
42PDK41.08276645
43PDK31.08276645
44UHMK11.05774390
45PHKG21.03334528
46PHKG11.03334528
47BRAF1.03303091
48KSR11.02140833
49CSNK1G11.01685555
50ADRBK11.00774827
51OXSR11.00084703
52PAK61.00035665
53CAMK2B0.99497727
54EPHA30.97399071
55STK380.94822269
56SGK20.88795957
57PRKCE0.88579945
58SGK2230.88260143
59SGK4940.88260143
60CDK180.88182078
61CDK140.85480196
62CDK150.82777899
63SIK30.81058938
64SIK20.79965192
65CAMK40.79939174
66PRPF4B0.79659311
67BCR0.79216751
68TAOK10.76649151
69PRKCZ0.76376050
70KSR20.75601258
71DYRK1A0.75408121
72LIMK10.73811362
73FES0.73448035
74PAK30.72744971
75MAP3K60.72032704
76CAMK2D0.71503276
77CDK11A0.70535045
78BMPR20.70255735
79TESK10.70015957
80FGR0.68632609
81MYLK0.67847639
82CAMK2G0.67039477
83CCNB10.65837090
84PKN10.64033166
85RET0.61348194
86CAMK10.60382306
87GRK60.60206017
88PDK20.57238491
89WNK30.56572682
90MAPK120.55680661
91CAMKK20.54560348
92PTK2B0.54467860
93SCYL20.53564403
94ICK0.52617140
95CAMK1G0.52018797
96BMPR1B0.49746552
97CAMKK10.49720088
98CSNK1D0.48564940
99PRKD30.47770869
100FER0.46286850
101STK110.45816750
102MAP2K10.44456010
103PRKACA0.44236892
104SGK30.43731862
105CSNK1A10.43711509
106STK390.43582858
107PRKCB0.42541313
108DYRK30.42237097
109CSNK1A1L0.41541342
110ROCK20.40734290
111SGK10.39929820
112INSRR0.39593084
113RPS6KA30.38955818
114TNK20.38859482
115CSNK1E0.38475967
116WNK40.38193638
117PRKACB0.37574352
118PRKCH0.37328595
119CDK30.37322803
120DYRK20.37218988
121PLK40.36398064
122LMTK20.35950156
123ACVR1B0.35648933
124PRKG10.34817329
125MAPK90.34794101
126MKNK20.33580460
127PRKAA10.33555424
128PRKACG0.32292863
129MAPK100.31039999
130OBSCN0.29777315
131NEK60.29011085
132PRKCA0.28989099
133BRD40.28514768
134ROCK10.27754719

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.12254392
2Nicotine addiction_Homo sapiens_hsa050334.08520596
3Collecting duct acid secretion_Homo sapiens_hsa049663.12970768
4GABAergic synapse_Homo sapiens_hsa047272.77252189
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65462596
6Amphetamine addiction_Homo sapiens_hsa050312.42976916
7Oxidative phosphorylation_Homo sapiens_hsa001902.39411945
8Morphine addiction_Homo sapiens_hsa050322.35251474
9Olfactory transduction_Homo sapiens_hsa047402.22982667
10Circadian entrainment_Homo sapiens_hsa047132.22953349
11Dopaminergic synapse_Homo sapiens_hsa047282.21729119
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21281138
13Serotonergic synapse_Homo sapiens_hsa047262.15110667
14Cocaine addiction_Homo sapiens_hsa050302.13150860
15Long-term potentiation_Homo sapiens_hsa047202.07767865
16Glutamatergic synapse_Homo sapiens_hsa047242.04025296
17Long-term depression_Homo sapiens_hsa047301.97585600
18Vibrio cholerae infection_Homo sapiens_hsa051101.97156063
19Parkinsons disease_Homo sapiens_hsa050121.95144554
20Taste transduction_Homo sapiens_hsa047421.73994444
21Cholinergic synapse_Homo sapiens_hsa047251.71924447
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71616793
23Salivary secretion_Homo sapiens_hsa049701.71483451
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68753783
25Insulin secretion_Homo sapiens_hsa049111.57420858
26Alzheimers disease_Homo sapiens_hsa050101.55554519
27Renin secretion_Homo sapiens_hsa049241.51271552
28Cardiac muscle contraction_Homo sapiens_hsa042601.50849929
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48251960
30Calcium signaling pathway_Homo sapiens_hsa040201.45781067
31Gastric acid secretion_Homo sapiens_hsa049711.37804798
32Circadian rhythm_Homo sapiens_hsa047101.36858992
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36398604
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26522834
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25852280
36Type I diabetes mellitus_Homo sapiens_hsa049401.25426171
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23932208
38Oxytocin signaling pathway_Homo sapiens_hsa049211.21456780
39Phototransduction_Homo sapiens_hsa047441.19707638
40Gap junction_Homo sapiens_hsa045401.19398932
41Huntingtons disease_Homo sapiens_hsa050161.08039421
42Butanoate metabolism_Homo sapiens_hsa006501.02394705
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00490538
44Rheumatoid arthritis_Homo sapiens_hsa053230.99201133
45GnRH signaling pathway_Homo sapiens_hsa049120.93986261
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90633786
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86769792
48Axon guidance_Homo sapiens_hsa043600.86585498
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85928390
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85225687
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84410121
52Phagosome_Homo sapiens_hsa041450.82937606
53cAMP signaling pathway_Homo sapiens_hsa040240.81877019
54Estrogen signaling pathway_Homo sapiens_hsa049150.80132779
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77841956
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77628736
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74454952
58ErbB signaling pathway_Homo sapiens_hsa040120.72747508
59Dilated cardiomyopathy_Homo sapiens_hsa054140.72714690
60Melanogenesis_Homo sapiens_hsa049160.69178966
61Ether lipid metabolism_Homo sapiens_hsa005650.68571695
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67853734
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67578112
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.67375546
65Glioma_Homo sapiens_hsa052140.65546469
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64963304
67Alcoholism_Homo sapiens_hsa050340.64251171
68Steroid biosynthesis_Homo sapiens_hsa001000.63648404
69Fatty acid biosynthesis_Homo sapiens_hsa000610.60839214
70Oocyte meiosis_Homo sapiens_hsa041140.59466122
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58624638
72Type II diabetes mellitus_Homo sapiens_hsa049300.57111724
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56353184
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54595841
75Thyroid hormone synthesis_Homo sapiens_hsa049180.52612193
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51524017
77Bile secretion_Homo sapiens_hsa049760.51142515
78MAPK signaling pathway_Homo sapiens_hsa040100.51014996
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49368126
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48426260
81Pyruvate metabolism_Homo sapiens_hsa006200.47619593
82Phenylalanine metabolism_Homo sapiens_hsa003600.46415659
83Ovarian steroidogenesis_Homo sapiens_hsa049130.46172954
84Pancreatic secretion_Homo sapiens_hsa049720.45406418
85Glucagon signaling pathway_Homo sapiens_hsa049220.45343626
86Dorso-ventral axis formation_Homo sapiens_hsa043200.45241545
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45033881
88African trypanosomiasis_Homo sapiens_hsa051430.43375491
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43138977
90beta-Alanine metabolism_Homo sapiens_hsa004100.42539030
91Ras signaling pathway_Homo sapiens_hsa040140.41718819
92AMPK signaling pathway_Homo sapiens_hsa041520.41647989
93Tyrosine metabolism_Homo sapiens_hsa003500.41560300
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.40295931
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40188070
96Protein export_Homo sapiens_hsa030600.39550699
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37061945
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36621445
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36053447
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36048524
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34667987
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34667453
103Melanoma_Homo sapiens_hsa052180.34389896
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34100400
105Linoleic acid metabolism_Homo sapiens_hsa005910.32340367
106Prion diseases_Homo sapiens_hsa050200.32239290
107Rap1 signaling pathway_Homo sapiens_hsa040150.31425656
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31362433
109Selenocompound metabolism_Homo sapiens_hsa004500.27821278
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27648736
111Fatty acid elongation_Homo sapiens_hsa000620.26775502
112Peroxisome_Homo sapiens_hsa041460.26423451
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24436460
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23684538
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.23228405
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23091356
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.22011315
118Choline metabolism in cancer_Homo sapiens_hsa052310.20382097
119Regulation of autophagy_Homo sapiens_hsa041400.18072807
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18049138
121Insulin signaling pathway_Homo sapiens_hsa049100.18013966
122Inositol phosphate metabolism_Homo sapiens_hsa005620.16975889

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