VWCE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.53286373
2L-phenylalanine catabolic process (GO:0006559)7.53286373
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.21977502
4L-phenylalanine metabolic process (GO:0006558)7.21977502
5aromatic amino acid family catabolic process (GO:0009074)6.75935077
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.47985373
7tryptophan catabolic process (GO:0006569)6.10705802
8indole-containing compound catabolic process (GO:0042436)6.10705802
9indolalkylamine catabolic process (GO:0046218)6.10705802
10kynurenine metabolic process (GO:0070189)6.00412790
11glyoxylate metabolic process (GO:0046487)5.81095471
12bile acid biosynthetic process (GO:0006699)5.80771133
13tryptophan metabolic process (GO:0006568)5.74646450
14high-density lipoprotein particle remodeling (GO:0034375)5.63821088
15negative regulation of fibrinolysis (GO:0051918)5.60139351
16urea cycle (GO:0000050)5.59452881
17urea metabolic process (GO:0019627)5.59452881
18alpha-linolenic acid metabolic process (GO:0036109)5.56139333
19cysteine metabolic process (GO:0006534)5.41473724
20regulation of fibrinolysis (GO:0051917)5.37322355
21sulfur amino acid catabolic process (GO:0000098)5.31874261
22peptidyl-glutamic acid carboxylation (GO:0017187)5.28430911
23protein carboxylation (GO:0018214)5.28430911
24regulation of protein activation cascade (GO:2000257)5.20368199
25serine family amino acid catabolic process (GO:0009071)5.17182639
26nitrogen cycle metabolic process (GO:0071941)5.13907975
27regulation of plasminogen activation (GO:0010755)5.12383939
28protein-lipid complex subunit organization (GO:0071825)5.11551638
29complement activation, alternative pathway (GO:0006957)5.04941301
30bile acid metabolic process (GO:0008206)4.99204672
31reverse cholesterol transport (GO:0043691)4.97877570
32regulation of cholesterol esterification (GO:0010872)4.95933221
33aromatic amino acid family metabolic process (GO:0009072)4.91506067
34regulation of complement activation (GO:0030449)4.85978733
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85411905
36regulation of triglyceride catabolic process (GO:0010896)4.84836427
37macromolecular complex remodeling (GO:0034367)4.82380004
38plasma lipoprotein particle remodeling (GO:0034369)4.82380004
39protein-lipid complex remodeling (GO:0034368)4.82380004
40regulation of apoptotic cell clearance (GO:2000425)4.79874739
41homocysteine metabolic process (GO:0050667)4.76531471
42lysine catabolic process (GO:0006554)4.73837042
43lysine metabolic process (GO:0006553)4.73837042
44negative regulation of sterol transport (GO:0032372)4.71731295
45negative regulation of cholesterol transport (GO:0032375)4.71731295
46tyrosine metabolic process (GO:0006570)4.71316459
47phospholipid efflux (GO:0033700)4.69414800
48acylglycerol homeostasis (GO:0055090)4.66623631
49triglyceride homeostasis (GO:0070328)4.66623631
50amino-acid betaine metabolic process (GO:0006577)4.64054364
51alpha-amino acid catabolic process (GO:1901606)4.63039094
52cellular ketone body metabolic process (GO:0046950)4.48069904
53glycine metabolic process (GO:0006544)4.44371425
54plasma lipoprotein particle clearance (GO:0034381)4.43792269
55bile acid and bile salt transport (GO:0015721)4.38353127
56intestinal absorption (GO:0050892)4.38140573
57nephron epithelium morphogenesis (GO:0072088)4.35527927
58nephron tubule morphogenesis (GO:0072078)4.35527927
59imidazole-containing compound metabolic process (GO:0052803)4.33759612
60cholesterol efflux (GO:0033344)4.32653679
61indolalkylamine metabolic process (GO:0006586)4.31487188
62glutamate metabolic process (GO:0006536)4.31041850
63cellular amino acid catabolic process (GO:0009063)4.27116628
64coenzyme catabolic process (GO:0009109)4.25706210
65cellular glucuronidation (GO:0052695)4.25647088
66serine family amino acid metabolic process (GO:0009069)4.25277376
67amine catabolic process (GO:0009310)4.22677672
68cellular biogenic amine catabolic process (GO:0042402)4.22677672
69drug catabolic process (GO:0042737)4.15083805
70plasma lipoprotein particle assembly (GO:0034377)4.14694658
71cellular modified amino acid catabolic process (GO:0042219)4.14293006
72serine family amino acid biosynthetic process (GO:0009070)4.12109890
73benzene-containing compound metabolic process (GO:0042537)4.11177737
74lung epithelium development (GO:0060428)4.07097799
75dicarboxylic acid biosynthetic process (GO:0043650)4.02748332
76ethanol oxidation (GO:0006069)4.02648398
77fibrinolysis (GO:0042730)4.01942933
78regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.99528208
79arginine metabolic process (GO:0006525)3.99215337
80aldehyde catabolic process (GO:0046185)3.95774168
81proline metabolic process (GO:0006560)3.94102162
82low-density lipoprotein particle remodeling (GO:0034374)3.93153755
83positive regulation of lipoprotein lipase activity (GO:0051006)3.92268943
84positive regulation of triglyceride lipase activity (GO:0061365)3.92268943
85peptidyl-glutamic acid modification (GO:0018200)3.91944852
86sterol transport (GO:0015918)3.87893526
87cholesterol transport (GO:0030301)3.87893526
88ketone body metabolic process (GO:1902224)3.87190506
89regulation of bile acid biosynthetic process (GO:0070857)3.84220053
90cholesterol homeostasis (GO:0042632)3.82738195
91blood coagulation, intrinsic pathway (GO:0007597)3.82581726
92very-low-density lipoprotein particle assembly (GO:0034379)3.80543053
93uronic acid metabolic process (GO:0006063)3.80000893
94glucuronate metabolic process (GO:0019585)3.80000893
95regulation of cholesterol homeostasis (GO:2000188)3.78874723
96C4-dicarboxylate transport (GO:0015740)3.78746369
97negative regulation of protein activation cascade (GO:2000258)3.78261949
98sterol homeostasis (GO:0055092)3.76837821
99phospholipid homeostasis (GO:0055091)3.76384884
100regulation of non-canonical Wnt signaling pathway (GO:2000050)3.74961947
101positive regulation of lipid catabolic process (GO:0050996)3.73803701
102organic acid catabolic process (GO:0016054)3.72971644
103carboxylic acid catabolic process (GO:0046395)3.72971644
104short-chain fatty acid metabolic process (GO:0046459)3.72604013
105protein-lipid complex assembly (GO:0065005)3.72312029
106cofactor catabolic process (GO:0051187)3.71222977
107plasma lipoprotein particle organization (GO:0071827)3.70414504
108transepithelial transport (GO:0070633)3.69960992
109negative regulation of lipase activity (GO:0060192)3.69666784
110acetyl-CoA metabolic process (GO:0006084)3.65311249
111complement activation, classical pathway (GO:0006958)3.62652602
112protein activation cascade (GO:0072376)3.60351881
113complement activation (GO:0006956)3.58195253
114positive regulation of fatty acid biosynthetic process (GO:0045723)3.56997419
115intestinal cholesterol absorption (GO:0030299)3.56569233
116NAD biosynthetic process (GO:0009435)3.56243454
117lipoprotein metabolic process (GO:0042157)3.55099929
118regulation of cholesterol biosynthetic process (GO:0045540)3.50569908
119positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.49056352
120negative regulation of digestive system process (GO:0060457)3.40119021
121positive regulation of blood coagulation (GO:0030194)3.38839717
122positive regulation of hemostasis (GO:1900048)3.38839717
123neurotransmitter-gated ion channel clustering (GO:0072578)3.31411167
124diacylglycerol metabolic process (GO:0046339)3.31405271
125trivalent inorganic anion homeostasis (GO:0072506)3.31214550
126phosphate ion homeostasis (GO:0055062)3.31214550
127regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.28049299
128L-ascorbic acid metabolic process (GO:0019852)3.22287245
129urate metabolic process (GO:0046415)3.20861966
130lipid homeostasis (GO:0055088)3.20438708
131negative regulation of blood coagulation (GO:0030195)3.19779940
132negative regulation of hemostasis (GO:1900047)3.19779940
133modified amino acid transport (GO:0072337)3.16494629
134positive regulation of steroid metabolic process (GO:0045940)3.16280238
135cellular anion homeostasis (GO:0030002)3.12241555
136low-density lipoprotein particle clearance (GO:0034383)3.06909336
137positive regulation of hormone metabolic process (GO:0032352)3.06556670
138positive regulation of coagulation (GO:0050820)3.04249981
139negative regulation of astrocyte differentiation (GO:0048712)2.99652091
140regulation of humoral immune response (GO:0002920)2.95966766
141cholesterol biosynthetic process (GO:0006695)2.94581278
142negative regulation of complement activation (GO:0045916)2.93672349
143renal tubule morphogenesis (GO:0061333)2.91884825
144vitamin transmembrane transport (GO:0035461)2.90722977
145negative regulation of coagulation (GO:0050819)2.89256206
146negative regulation of sodium ion transport (GO:0010766)2.88983890
147acute-phase response (GO:0006953)2.88709287
148drug transmembrane transport (GO:0006855)2.82582504
149regulation of norepinephrine secretion (GO:0014061)2.79764699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.46091191
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.27001865
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.91525139
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.54251069
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23642230
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.09617090
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89508573
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02909735
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.99901062
10ZNF274_21170338_ChIP-Seq_K562_Hela3.90429142
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.68978805
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.67829841
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.22707926
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13979216
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07827928
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0308208
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99281199
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86038332
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79544664
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78897104
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77120871
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71949724
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67378221
24CLOCK_20551151_ChIP-Seq_293T_Human1.62946169
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.61103513
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61083857
27IRF1_19129219_ChIP-ChIP_H3396_Human1.54790573
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54488924
29GATA1_22025678_ChIP-Seq_K562_Human1.48865731
30GABP_19822575_ChIP-Seq_HepG2_Human1.48756146
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48714158
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.48169909
33* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45740700
34HTT_18923047_ChIP-ChIP_STHdh_Human1.44062884
35ETV2_25802403_ChIP-Seq_MESCs_Mouse1.42510296
36RAC3_21632823_ChIP-Seq_H3396_Human1.41604140
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.40661925
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.36907489
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33205125
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.31426376
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29857769
42IGF1R_20145208_ChIP-Seq_DFB_Human1.26719384
43ERA_21632823_ChIP-Seq_H3396_Human1.26206522
44* OCT4_20526341_ChIP-Seq_ESCs_Human1.25443502
45FOXP3_21729870_ChIP-Seq_TREG_Human1.22909775
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.22730109
47* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20742302
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19295246
49MYC_19829295_ChIP-Seq_ESCs_Human1.18993395
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18853586
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.17467503
52E2F1_20622854_ChIP-Seq_HELA_Human1.17392838
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15647577
54FOXP1_21924763_ChIP-Seq_HESCs_Human1.13209294
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11516215
56EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.11496136
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10100695
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09228507
59NANOG_20526341_ChIP-Seq_ESCs_Human1.08076044
60FOXH1_21741376_ChIP-Seq_ESCs_Human1.07025257
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04572677
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02105029
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01393297
64TP53_22127205_ChIP-Seq_IMR90_Human1.00923448
65* P68_20966046_ChIP-Seq_HELA_Human1.00544925
66* ELF1_20517297_ChIP-Seq_JURKAT_Human1.00514669
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.00384898
68PHF8_20622854_ChIP-Seq_HELA_Human0.99449521
69YY1_22570637_ChIP-Seq_MALME-3M_Human0.99215560
70REST_18959480_ChIP-ChIP_MESCs_Mouse0.96295624
71RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96022266
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95751711
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95156240
74MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95084182
75* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94585790
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93305604
77VDR_22108803_ChIP-Seq_LS180_Human0.91995898
78TP53_22573176_ChIP-Seq_HFKS_Human0.91922675
79GATA4_25053715_ChIP-Seq_YYC3_Human0.90489261
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89206569
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88555204
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.86688667
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84522453
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83254951
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82958623
86E2F1_17053090_ChIP-ChIP_MCF-7_Human0.82728319
87* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.82034437
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81346486
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81053701
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80039855
91ZNF263_19887448_ChIP-Seq_K562_Human0.78390504
92BCL6_27268052_Chip-Seq_Bcells_Human0.78134711
93* RARA_24833708_ChIP-Seq_LIVER_Mouse0.77645644
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.77363479
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77362530
96* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76983688
97NANOG_19829295_ChIP-Seq_ESCs_Human0.75321514
98SOX2_19829295_ChIP-Seq_ESCs_Human0.75321514
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75031257
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74744281
101VDR_23849224_ChIP-Seq_CD4+_Human0.74628303
102REST_21632747_ChIP-Seq_MESCs_Mouse0.74564722
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74451440
104AR_21572438_ChIP-Seq_LNCaP_Human0.73572281
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73488212
106ESR2_21235772_ChIP-Seq_MCF-7_Human0.72592772
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72507578
108IRF8_22096565_ChIP-ChIP_GC-B_Human0.72280437
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71210059
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70491553
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67826513
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66908110
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66170558
114* RARB_24833708_ChIP-Seq_LIVER_Mouse0.65370598
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65244786
116RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63740935
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63587887
118* LXR_22292898_ChIP-Seq_THP-1_Human0.63285639
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.62403431
120CEBPB_22108803_ChIP-Seq_LS180_Human0.58436270
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54419594
122MYC_19915707_ChIP-ChIP_AK7_Human0.53933594
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.53485713
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.53485713
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.52625980
126CDX2_20551321_ChIP-Seq_CACO-2_Human0.52594475
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.51689584
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.51428553
129EGR1_19032775_ChIP-ChIP_M12_Human0.50687907
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.50084808
131AR_20517297_ChIP-Seq_VCAP_Human0.49965047
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49594861
133* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49004651
134ESET_19884257_ChIP-Seq_ESCs_Mouse0.47740501
135* GATA6_25053715_ChIP-Seq_YYC3_Human0.47703920
136P53_21459846_ChIP-Seq_SAOS-2_Human0.46763258
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.45744525
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45255820
139* STAT1_17558387_ChIP-Seq_HELA_Human0.45221849
140PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44827079
141PPAR_26484153_Chip-Seq_NCI-H1993_Human0.44534647
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44508184
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.44210416
144* GATA1_19941826_ChIP-Seq_K562_Human0.43778783
145* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43657885
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43494280
147* CBP_21632823_ChIP-Seq_H3396_Human0.43151500
148* GATA2_19941826_ChIP-Seq_K562_Human0.41244936
149* TAF2_19829295_ChIP-Seq_ESCs_Human0.40802045
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.38432955
151STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38084169
152CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37799390
153SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.37669765
154BCOR_27268052_Chip-Seq_Bcells_Human0.36635492
155GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.36199275
156* MYC_27129775_Chip-Seq_CORNEA_Mouse0.35494796
157LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35258580
158SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.35162120
159SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34820265
160P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.34773280
161* RACK7_27058665_Chip-Seq_MCF-7_Human0.34648237
162ESR1_20079471_ChIP-ChIP_T-47D_Human0.34575434
163CSB_26484114_Chip-Seq_FIBROBLAST_Human0.34547660
164* SPI1_26923725_Chip-Seq_HPCs_Mouse0.34542081
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.34525724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.30736725
2MP0005360_urolithiasis7.75703007
3MP0005085_abnormal_gallbladder_physiolo6.35092667
4MP0005365_abnormal_bile_salt6.07671795
5MP0003122_maternal_imprinting5.56674853
6MP0008875_abnormal_xenobiotic_pharmacok5.14431542
7MP0003806_abnormal_nucleotide_metabolis4.13910663
8MP0003252_abnormal_bile_duct3.94814265
9MP0010329_abnormal_lipoprotein_level3.60186272
10MP0009840_abnormal_foam_cell3.37165535
11MP0005083_abnormal_biliary_tract3.03578268
12MP0000566_synostosis2.96559555
13MP0005332_abnormal_amino_acid2.84097410
14MP0003195_calcinosis2.83831031
15MP0001666_abnormal_nutrient_absorption2.70010810
16MP0003172_abnormal_lysosome_physiology2.54910844
17MP0003878_abnormal_ear_physiology2.33298218
18MP0005377_hearing/vestibular/ear_phenot2.33298218
19MP0003123_paternal_imprinting2.33046744
20MP0003191_abnormal_cellular_cholesterol2.31009677
21MP0006292_abnormal_olfactory_placode2.29489790
22MP0003121_genomic_imprinting2.29355201
23MP0004019_abnormal_vitamin_homeostasis2.28021321
24MP0000609_abnormal_liver_physiology2.16054393
25MP0002118_abnormal_lipid_homeostasis2.08518153
26MP0002138_abnormal_hepatobiliary_system1.98641396
27MP0002089_abnormal_postnatal_growth/wei1.88149071
28MP0005319_abnormal_enzyme/_coenzyme1.81626637
29MP0003868_abnormal_feces_composition1.80915409
30MP0001293_anophthalmia1.76549964
31MP0001764_abnormal_homeostasis1.67611626
32MP0003567_abnormal_fetal_cardiomyocyte1.65490639
33MP0005584_abnormal_enzyme/coenzyme_acti1.55262924
34MP0009697_abnormal_copulation1.54575687
35MP0003136_yellow_coat_color1.48286644
36MP0005451_abnormal_body_composition1.47826910
37MP0005167_abnormal_blood-brain_barrier1.47256395
38MP0002938_white_spotting1.46626264
39MP0005551_abnormal_eye_electrophysiolog1.44930239
40MP0003656_abnormal_erythrocyte_physiolo1.40070393
41MP0009643_abnormal_urine_homeostasis1.33869610
42MP0003011_delayed_dark_adaptation1.33263120
43MP0004133_heterotaxia1.28854625
44MP0003186_abnormal_redox_activity1.22408719
45MP0006054_spinal_hemorrhage1.21508533
46MP0001915_intracranial_hemorrhage1.19454168
47MP0003705_abnormal_hypodermis_morpholog1.18813202
48MP0000598_abnormal_liver_morphology1.18539960
49MP0002254_reproductive_system_inflammat1.14932203
50MP0002638_abnormal_pupillary_reflex1.14291068
51MP0000604_amyloidosis1.10707103
52MP0005379_endocrine/exocrine_gland_phen1.07432578
53MP0005647_abnormal_sex_gland1.07388513
54MP0005636_abnormal_mineral_homeostasis1.04764473
55MP0005646_abnormal_pituitary_gland1.03332843
56MP0009764_decreased_sensitivity_to1.02546478
57MP0001529_abnormal_vocalization1.02000567
58MP0009763_increased_sensitivity_to0.97183372
59MP0010368_abnormal_lymphatic_system0.93469473
60MP0001324_abnormal_eye_pigmentation0.93310930
61MP0001270_distended_abdomen0.92731752
62MP0000372_irregular_coat_pigmentation0.92058580
63MP0009642_abnormal_blood_homeostasis0.87702657
64MP0005410_abnormal_fertilization0.87277540
65MP0008469_abnormal_protein_level0.86542365
66MP0005084_abnormal_gallbladder_morpholo0.85350976
67MP0008877_abnormal_DNA_methylation0.84793298
68MP0005408_hypopigmentation0.84615244
69MP0001984_abnormal_olfaction0.83196534
70MP0005195_abnormal_posterior_eye0.83012235
71MP0006036_abnormal_mitochondrial_physio0.82977189
72MP0001286_abnormal_eye_development0.82200553
73MP0001986_abnormal_taste_sensitivity0.81487199
74MP0005376_homeostasis/metabolism_phenot0.80260166
75MP0005394_taste/olfaction_phenotype0.77698616
76MP0005499_abnormal_olfactory_system0.77698616
77MP0003787_abnormal_imprinting0.77029858
78MP0002876_abnormal_thyroid_physiology0.76852868
79MP0002078_abnormal_glucose_homeostasis0.76058453
80MP0009765_abnormal_xenobiotic_induced0.75658584
81MP0003943_abnormal_hepatobiliary_system0.75566638
82MP0009046_muscle_twitch0.73815160
83MP0002160_abnormal_reproductive_system0.73478155
84MP0002092_abnormal_eye_morphology0.73268788
85MP0005670_abnormal_white_adipose0.73211179
86MP0009053_abnormal_anal_canal0.72931263
87MP0005220_abnormal_exocrine_pancreas0.71520895
88MP0001756_abnormal_urination0.70446059
89MP0001661_extended_life_span0.70267579
90MP0002557_abnormal_social/conspecific_i0.69231593
91MP0003119_abnormal_digestive_system0.68680661
92MP0002971_abnormal_brown_adipose0.68650193
93MP0005334_abnormal_fat_pad0.66627864
94MP0002697_abnormal_eye_size0.65658914
95MP0003329_amyloid_beta_deposits0.65474537
96MP0002233_abnormal_nose_morphology0.64458295
97MP0004142_abnormal_muscle_tone0.63653422
98MP0003942_abnormal_urinary_system0.63130649
99MP0005391_vision/eye_phenotype0.62991662
100MP0005266_abnormal_metabolism0.62932127
101MP0002163_abnormal_gland_morphology0.62698260
102MP0005535_abnormal_body_temperature0.60901841
103MP0002282_abnormal_trachea_morphology0.60271625
104MP0003890_abnormal_embryonic-extraembry0.60218500
105MP0003879_abnormal_hair_cell0.60056165
106MP0004130_abnormal_muscle_cell0.58785412
107MP0000639_abnormal_adrenal_gland0.57236753
108MP0004147_increased_porphyrin_level0.56820729
109MP0005448_abnormal_energy_balance0.56361548
110MP0003690_abnormal_glial_cell0.55550416
111MP0006035_abnormal_mitochondrial_morpho0.55321141
112MP0002136_abnormal_kidney_physiology0.54616571
113MP0003698_abnormal_male_reproductive0.54402970
114MP0002909_abnormal_adrenal_gland0.53631317
115MP0008789_abnormal_olfactory_epithelium0.53588636
116MP0005389_reproductive_system_phenotype0.53140916
117MP0003718_maternal_effect0.52898393
118MP0005395_other_phenotype0.51601079
119MP0005464_abnormal_platelet_physiology0.50573905
120MP0004885_abnormal_endolymph0.50524760
121MP0003638_abnormal_response/metabolism_0.46939721
122MP0002822_catalepsy0.45823197
123MP0002928_abnormal_bile_duct0.44356946
124MP0008873_increased_physiological_sensi0.42919307
125MP0008874_decreased_physiological_sensi0.40611189
126MP0003953_abnormal_hormone_level0.40586244
127MP0003436_decreased_susceptibility_to0.40029914
128MP0009672_abnormal_birth_weight0.39330128
129MP0008872_abnormal_physiological_respon0.38240629
130MP0004782_abnormal_surfactant_physiolog0.37520375
131MP0005166_decreased_susceptibility_to0.36802324
132MP0002796_impaired_skin_barrier0.35396369
133MP0004883_abnormal_blood_vessel0.35365243
134MP0005248_abnormal_Harderian_gland0.35037433
135MP0002837_dystrophic_cardiac_calcinosis0.34963472
136MP0005666_abnormal_adipose_tissue0.34949990
137MP0003075_altered_response_to0.34456725
138MP0001243_abnormal_dermal_layer0.33860424
139MP0000230_abnormal_systemic_arterial0.32926351
140MP0009115_abnormal_fat_cell0.32693807
141MP0000249_abnormal_blood_vessel0.32637446
142MP0002168_other_aberrant_phenotype0.32415566
143MP0003724_increased_susceptibility_to0.32367453
144MP0004264_abnormal_extraembryonic_tissu0.30006950
145MP0002970_abnormal_white_adipose0.29514325
146MP0004381_abnormal_hair_follicle0.28672440
147MP0006082_CNS_inflammation0.28139582
148MP0001881_abnormal_mammary_gland0.27805582
149MP0000579_abnormal_nail_morphology0.27461573
150MP0009384_cardiac_valve_regurgitation0.27311910
151MP0004043_abnormal_pH_regulation0.27077467
152MP0001845_abnormal_inflammatory_respons0.26714711
153MP0005058_abnormal_lysosome_morphology0.26700637
154MP0002132_abnormal_respiratory_system0.26448213
155MP0001765_abnormal_ion_homeostasis0.26295907

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.35716716
2Deep venous thrombosis (HP:0002625)7.32641364
3Intrahepatic cholestasis (HP:0001406)7.12022029
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.58138841
5Hypobetalipoproteinemia (HP:0003563)6.44864075
6Prolonged partial thromboplastin time (HP:0003645)6.35906985
7Xanthomatosis (HP:0000991)6.27033393
8Hyperlipoproteinemia (HP:0010980)5.39781505
9Complement deficiency (HP:0004431)5.01464111
10Hypolipoproteinemia (HP:0010981)4.82049388
11Joint hemorrhage (HP:0005261)4.71688902
12Hyperammonemia (HP:0001987)4.61249704
13Hyperglycinemia (HP:0002154)4.48658690
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.39160460
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.35821544
16Epidermoid cyst (HP:0200040)4.32539632
17Abnormality of the common coagulation pathway (HP:0010990)4.32527589
18Ketosis (HP:0001946)4.28839133
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.26968665
20Hypoalphalipoproteinemia (HP:0003233)4.18544264
21Abnormality of methionine metabolism (HP:0010901)4.15216538
22Hyperglycinuria (HP:0003108)4.13543505
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12268975
24Abnormality of glycine metabolism (HP:0010895)4.08111267
25Abnormality of serine family amino acid metabolism (HP:0010894)4.08111267
26Fat malabsorption (HP:0002630)4.04442733
27Hypoglycemic coma (HP:0001325)3.83604017
28Abnormality of pyrimidine metabolism (HP:0004353)3.82217537
29Conjugated hyperbilirubinemia (HP:0002908)3.77693266
30Abnormality of complement system (HP:0005339)3.65480684
31Abnormality of the intrinsic pathway (HP:0010989)3.62546447
32Broad alveolar ridges (HP:0000187)3.62009670
33Hypercholesterolemia (HP:0003124)3.61846581
34Pancreatic islet-cell hyperplasia (HP:0004510)3.52049201
35Hyperbilirubinemia (HP:0002904)3.46082911
36Abnormality of fatty-acid metabolism (HP:0004359)3.36174418
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.31380487
38Abnormality of nucleobase metabolism (HP:0010932)3.19769091
39Vaginal fistula (HP:0004320)3.14630362
40Delayed CNS myelination (HP:0002188)3.12028779
41Irregular epiphyses (HP:0010582)3.09144286
42Small epiphyses (HP:0010585)3.05707317
43Abnormality of serum amino acid levels (HP:0003112)3.04902499
44Hepatocellular carcinoma (HP:0001402)3.03689354
45Ketoacidosis (HP:0001993)3.03241622
46Supernumerary spleens (HP:0009799)2.99995037
47Hypochromic microcytic anemia (HP:0004840)2.98292085
48Arthropathy (HP:0003040)2.95106333
49Steatorrhea (HP:0002570)2.94786917
50Myocardial infarction (HP:0001658)2.93898179
51Spontaneous abortion (HP:0005268)2.92374854
52Abnormality of purine metabolism (HP:0004352)2.88544868
53Metabolic acidosis (HP:0001942)2.85976998
54Hepatoblastoma (HP:0002884)2.83534906
55Acanthocytosis (HP:0001927)2.76698921
56Skin nodule (HP:0200036)2.70215500
57Gout (HP:0001997)2.69888247
58Systemic lupus erythematosus (HP:0002725)2.66818126
59Vascular calcification (HP:0004934)2.64923989
60Dicarboxylic aciduria (HP:0003215)2.62382830
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62382830
62Lethargy (HP:0001254)2.60594107
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.59111802
64Malnutrition (HP:0004395)2.56042126
65Abnormal gallbladder morphology (HP:0012437)2.52509991
66Epiphyseal dysplasia (HP:0002656)2.49777929
67Spastic diplegia (HP:0001264)2.49490093
68Cholelithiasis (HP:0001081)2.48451496
69Cholecystitis (HP:0001082)2.46673981
70Abnormal gallbladder physiology (HP:0012438)2.46673981
71Hypoglycemic seizures (HP:0002173)2.41976587
72Diastasis recti (HP:0001540)2.39833219
73Alacrima (HP:0000522)2.37519281
74Mitral stenosis (HP:0001718)2.36933054
75Glomerulonephritis (HP:0000099)2.36469290
76Irritability (HP:0000737)2.35987207
77Absent epiphyses (HP:0010577)2.35412487
78Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.35412487
79Cardiovascular calcification (HP:0011915)2.34845286
80Cerebral edema (HP:0002181)2.34376853
81Neonatal onset (HP:0003623)2.30656563
82Facial shape deformation (HP:0011334)2.29453526
83Potter facies (HP:0002009)2.29453526
84Poikilocytosis (HP:0004447)2.28360663
85Abnormality of the vitreous humor (HP:0004327)2.23891161
86Abnormality of the lumbar spine (HP:0100712)2.20970637
87Hypochromic anemia (HP:0001931)2.19916131
88Esophageal varix (HP:0002040)2.19810559
89Enlarged kidneys (HP:0000105)2.18974413
90Amyloidosis (HP:0011034)2.18458370
91Broad palm (HP:0001169)2.17272695
92Pigmentary retinal degeneration (HP:0001146)2.16710492
93Pancreatitis (HP:0001733)2.15897163
94Purpura (HP:0000979)2.15888930
95Late onset (HP:0003584)2.15003677
96Abnormality of proline metabolism (HP:0010907)2.14582529
97Hydroxyprolinuria (HP:0003080)2.14582529
98Menorrhagia (HP:0000132)2.14482693
99Widely patent fontanelles and sutures (HP:0004492)2.14441028
100Generalized aminoaciduria (HP:0002909)2.14004299
101Vomiting (HP:0002013)2.13822530
102Gingival bleeding (HP:0000225)2.12867626
103Abnormality of the wing of the ilium (HP:0011867)2.12297803
104Brushfield spots (HP:0001088)2.12063053
105Sensorimotor neuropathy (HP:0007141)2.12005244
106Increased serum pyruvate (HP:0003542)2.08958566
107Abnormality of the pancreatic islet cells (HP:0006476)2.08360697
108Abnormality of endocrine pancreas physiology (HP:0012093)2.08360697
109Rectovaginal fistula (HP:0000143)2.08180327
110Rectal fistula (HP:0100590)2.08180327
111Neoplasm of the liver (HP:0002896)2.08170418
112Vitreoretinal degeneration (HP:0000655)2.07413792
113Recurrent corneal erosions (HP:0000495)2.05920285
114Abnormality of the gallbladder (HP:0005264)2.05798600
115Recurrent gram-negative bacterial infections (HP:0005420)2.05433579
116Opisthotonus (HP:0002179)2.05238135
117Asymmetry of the thorax (HP:0001555)2.04504828
118Rickets (HP:0002748)2.02951319
119Hemorrhage of the eye (HP:0011885)2.02667203
120Thrombophlebitis (HP:0004418)2.02410971
121Abnormality of the nasal septum (HP:0000419)2.02103712
122Abnormal cartilage morphology (HP:0002763)1.97848709
123Pendular nystagmus (HP:0012043)1.95699070
124Alkalosis (HP:0001948)1.95650621
125Flared iliac wings (HP:0002869)1.95280297
126Abnormality of transition element cation homeostasis (HP:0011030)1.94985509
127Hyperinsulinemic hypoglycemia (HP:0000825)1.94551909
128Abnormality of iron homeostasis (HP:0011031)1.94096796
129Reticulocytosis (HP:0001923)1.93756477
130Anophthalmia (HP:0000528)1.93660001
131Hypophosphatemic rickets (HP:0004912)1.91422245
132Hypothermia (HP:0002045)1.90946551
133Proximal tubulopathy (HP:0000114)1.89309163
134Hyperuricemia (HP:0002149)1.88623054
135Increased purine levels (HP:0004368)1.88623054
136Abnormality of glycolysis (HP:0004366)1.87003903
137Abnormal enzyme/coenzyme activity (HP:0012379)1.84312479
138Renal cortical cysts (HP:0000803)1.82581381
139Decreased lacrimation (HP:0000633)1.81822239
140Glycosuria (HP:0003076)1.79756512
141Intestinal fistula (HP:0100819)1.78786056
142Status epilepticus (HP:0002133)1.73635834
143Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73057308
144Abnormal urine output (HP:0012590)1.72771476
145Osteomalacia (HP:0002749)1.71522876
146Abnormality of carpal bone ossification (HP:0006257)1.70755477
147Retinal atrophy (HP:0001105)1.70261159
148Abnormal biliary tract physiology (HP:0012439)1.69120067
149Bile duct proliferation (HP:0001408)1.69120067
150Pulmonary embolism (HP:0002204)1.61817669
151Abnormal tarsal ossification (HP:0008369)1.60908389
152Metaphyseal irregularity (HP:0003025)1.60733255
153Lissencephaly (HP:0001339)1.60052549
154Humeroradial synostosis (HP:0003041)1.58845328
155Synostosis involving the elbow (HP:0003938)1.58845328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15219092
2WNK45.71016512
3FGFR44.71741137
4SIK14.59455376
5ERN14.42691062
6TAOK33.10870719
7INSRR2.82854781
8TYRO32.69010840
9ERBB42.51892010
10MST1R2.43829157
11PKN22.35359691
12MAP2K42.18026172
13PIK3CA1.94497851
14TRIB31.90499975
15MAPK111.88181464
16FLT31.87437411
17SIK21.84579412
18PIK3CG1.84254344
19DYRK21.84165396
20LATS11.67513870
21TYK21.64738731
22AKT31.63046980
23PTK61.61918093
24WNK11.58289126
25FRK1.54593703
26MAP4K21.49855279
27CDK121.49643360
28TLK11.48981142
29STK391.45583612
30ABL21.44763676
31BRSK21.43118821
32DAPK21.41010194
33GRK61.36841472
34MAP3K101.35826034
35WNK31.35100557
36ZAK1.35017193
37KDR1.33723901
38NEK91.29090912
39NTRK21.27225887
40STK161.26587870
41PLK41.24109016
42MAP3K71.22728316
43MAP2K31.22340264
44NEK21.21740282
45ADRBK21.19885001
46FGFR21.18413325
47JAK21.14291043
48STK38L1.13528343
49PLK31.13517179
50PRKAA21.13511697
51MET1.05499755
52MAP3K31.04116176
53NME11.04009629
54ERBB21.01128936
55PINK10.98159424
56FGR0.97401598
57MAP3K110.97354385
58TBK10.95938735
59EIF2AK10.95205085
60MAPK40.93249742
61PRKCZ0.92686218
62DDR20.90559914
63MAPKAPK50.90333543
64EEF2K0.87875389
65MAPK150.87172124
66CDK60.86008193
67DYRK1B0.85598921
68JAK10.85590282
69BRSK10.84742910
70MAPK120.83692296
71MAP3K140.81525478
72MATK0.80122186
73EPHB10.79319523
74TGFBR20.76341331
75CDK70.75719277
76ITK0.75298584
77PRKACG0.75179841
78PTK20.73909402
79SRPK10.73195584
80NUAK10.72604882
81MAP2K60.72478483
82GSK3A0.72134149
83CSK0.72129510
84DYRK30.71944147
85TIE10.71333020
86VRK20.70802968
87BCR0.70422544
88PRKAA10.66520315
89MAP3K40.63034676
90DYRK1A0.61400172
91MAPK130.61332903
92SGK30.61249832
93RIPK10.60011549
94CAMK2G0.59492233
95TAOK20.58662715
96BMPR1B0.57909052
97MAPK70.56781726
98CAMK1D0.56586148
99VRK10.56497008
100IRAK30.55434969
101CSNK1D0.55194667
102EPHA30.54659375
103PDPK10.54279033
104CSNK1E0.54168260
105PLK20.50835166
106CDK40.50538304
107ICK0.49346763
108BRD40.48727067
109CSNK2A20.47630637
110MTOR0.46990901
111CSNK2A10.46493924
112CSF1R0.45106143
113CASK0.43667102
114CSNK1G10.43008124
115PRKCQ0.42746205
116SGK10.41370747
117IKBKE0.40998909
118ATM0.40768583
119MAP3K50.40733292
120TAF10.40647498
121MAP2K10.39599653
122MAP2K20.39244887
123GRK10.38924493
124SGK20.38362793
125CSNK1A10.37409092
126FGFR30.37195815
127IGF1R0.36766325
128RET0.35694486
129PKN10.35493675
130MAP3K10.34614437
131PRKACA0.34561878
132EPHA40.33779670
133PLK10.33748950
134MAP3K60.33297898
135STK110.33225626
136MAPKAPK30.33056232
137PRKCG0.32544218
138SGK2230.31461502
139SGK4940.31461502
140NTRK30.31398832
141MARK20.30948415
142PDK10.30902887
143ATR0.30667607
144RPS6KB10.30127759
145PRKG10.29084908
146PDGFRA0.29057330
147CSNK1A1L0.28512459
148BMX0.28500082
149EGFR0.27101994
150MAP3K130.26272471
151PBK0.26097714
152CAMK40.25701488
153STK30.25015770
154PRKCA0.24679102
155PDK40.24461946
156PDK30.24461946
157EPHB20.23890617
158FGFR10.21079582
159LATS20.20642844
160PAK30.19112291
161CSNK1G20.18213325
162MAPK30.17345847
163CSNK1G30.17224158

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.36383989
2Nitrogen metabolism_Homo sapiens_hsa009103.49448569
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.42138428
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32094176
5Arginine biosynthesis_Homo sapiens_hsa002203.02877594
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68755627
7Tryptophan metabolism_Homo sapiens_hsa003802.68483225
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68145279
9Complement and coagulation cascades_Homo sapiens_hsa046102.67800637
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56157780
11Fatty acid degradation_Homo sapiens_hsa000712.49345768
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39269010
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31763628
14Butanoate metabolism_Homo sapiens_hsa006502.18407008
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11976203
16Peroxisome_Homo sapiens_hsa041462.04921592
17Histidine metabolism_Homo sapiens_hsa003401.94460199
18Propanoate metabolism_Homo sapiens_hsa006401.91755266
19Chemical carcinogenesis_Homo sapiens_hsa052041.91700826
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89737831
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.88886463
22PPAR signaling pathway_Homo sapiens_hsa033201.86075959
23Fatty acid metabolism_Homo sapiens_hsa012121.80151160
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.76819012
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76655893
26beta-Alanine metabolism_Homo sapiens_hsa004101.73081709
27Other glycan degradation_Homo sapiens_hsa005111.71284481
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71064303
29Caffeine metabolism_Homo sapiens_hsa002321.68657116
30Retinol metabolism_Homo sapiens_hsa008301.67905409
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67858991
32Staphylococcus aureus infection_Homo sapiens_hsa051501.66724218
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65958544
34Selenocompound metabolism_Homo sapiens_hsa004501.58821140
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58358439
36Phenylalanine metabolism_Homo sapiens_hsa003601.52685404
37Bile secretion_Homo sapiens_hsa049761.52116747
38Pyruvate metabolism_Homo sapiens_hsa006201.42912800
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42176773
40Tyrosine metabolism_Homo sapiens_hsa003501.39522866
41Sulfur metabolism_Homo sapiens_hsa009201.34654726
42Starch and sucrose metabolism_Homo sapiens_hsa005001.31508504
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.30982201
44Fatty acid elongation_Homo sapiens_hsa000621.29654670
45Folate biosynthesis_Homo sapiens_hsa007901.29082700
46Fat digestion and absorption_Homo sapiens_hsa049751.28250307
47Biosynthesis of amino acids_Homo sapiens_hsa012301.22991918
48Steroid biosynthesis_Homo sapiens_hsa001001.21053161
49ABC transporters_Homo sapiens_hsa020101.20549525
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.18554489
51Carbon metabolism_Homo sapiens_hsa012001.16266050
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.04547398
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04275924
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03887953
55Arginine and proline metabolism_Homo sapiens_hsa003301.03488344
56Vitamin B6 metabolism_Homo sapiens_hsa007501.02831040
57Sulfur relay system_Homo sapiens_hsa041220.98555111
58Vitamin digestion and absorption_Homo sapiens_hsa049770.97768104
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92173436
60Protein export_Homo sapiens_hsa030600.88316030
61Lysine degradation_Homo sapiens_hsa003100.87571688
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86812193
63One carbon pool by folate_Homo sapiens_hsa006700.80873488
64N-Glycan biosynthesis_Homo sapiens_hsa005100.79937511
65Ether lipid metabolism_Homo sapiens_hsa005650.79109295
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74898192
67Glutathione metabolism_Homo sapiens_hsa004800.74329503
68Glycerolipid metabolism_Homo sapiens_hsa005610.71716246
69Pentose phosphate pathway_Homo sapiens_hsa000300.61739950
70RNA polymerase_Homo sapiens_hsa030200.58874747
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52935232
72Fatty acid biosynthesis_Homo sapiens_hsa000610.47891952
73Metabolic pathways_Homo sapiens_hsa011000.47287362
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46721255
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45195199
76Sphingolipid metabolism_Homo sapiens_hsa006000.44226704
77Basal transcription factors_Homo sapiens_hsa030220.38681655
78Oxidative phosphorylation_Homo sapiens_hsa001900.35276199
79Galactose metabolism_Homo sapiens_hsa000520.34705237
80Phototransduction_Homo sapiens_hsa047440.33362762
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32808447
82Fructose and mannose metabolism_Homo sapiens_hsa000510.30287118
83Fanconi anemia pathway_Homo sapiens_hsa034600.29368171
84Prion diseases_Homo sapiens_hsa050200.27529172
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27040688
86Homologous recombination_Homo sapiens_hsa034400.21551477
87Insulin resistance_Homo sapiens_hsa049310.21324202
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21211550
89Linoleic acid metabolism_Homo sapiens_hsa005910.21093239
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19826754
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.19196519
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18836422
93Purine metabolism_Homo sapiens_hsa002300.18459451
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.16616261
95Parkinsons disease_Homo sapiens_hsa050120.15393163
96Glucagon signaling pathway_Homo sapiens_hsa049220.08303536
97AMPK signaling pathway_Homo sapiens_hsa041520.01094527
98Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2511664
99Bladder cancer_Homo sapiens_hsa05219-0.2284176
100Protein digestion and absorption_Homo sapiens_hsa04974-0.2237031
101Mineral absorption_Homo sapiens_hsa04978-0.2120025
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2041374
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1995154
104Hepatitis C_Homo sapiens_hsa05160-0.1870869
105African trypanosomiasis_Homo sapiens_hsa05143-0.1733789
106Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1708082
107Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1681987
108Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1673506
109Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1642446
110Regulation of autophagy_Homo sapiens_hsa04140-0.1542466
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1211624
112Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1149280
113Insulin signaling pathway_Homo sapiens_hsa04910-0.1118388
114Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1002235
115Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0953661
116Renin-angiotensin system_Homo sapiens_hsa04614-0.0823318
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0546621
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0152954

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