VWDE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003579.06334959
2L-alpha-amino acid transmembrane transport (GO:1902475)7.65425351
3negative regulation of execution phase of apoptosis (GO:1900118)7.49874286
4negative regulation of digestive system process (GO:0060457)7.37988108
5Golgi transport vesicle coating (GO:0048200)7.27251926
6COPI coating of Golgi vesicle (GO:0048205)7.27251926
7nuclear pore complex assembly (GO:0051292)7.10545908
8peptide hormone processing (GO:0016486)6.85906784
9nuclear pore organization (GO:0006999)6.36553612
10positive regulation of insulin secretion (GO:0032024)5.92120871
11positive regulation of vesicle fusion (GO:0031340)5.89196516
12positive regulation of peptidyl-threonine phosphorylation (GO:0010800)5.81398605
13response to dietary excess (GO:0002021)5.46982774
14positive regulation of amino acid transport (GO:0051957)5.44014782
15negative regulation of JUN kinase activity (GO:0043508)5.41665187
16positive regulation of calcium ion import (GO:0090280)5.35512608
17pore complex assembly (GO:0046931)5.30669696
18DNA replication checkpoint (GO:0000076)5.26704149
19glandular epithelial cell differentiation (GO:0002067)5.12754648
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11986545
21COPII vesicle coating (GO:0048208)5.10846626
22toxin metabolic process (GO:0009404)5.06768973
23positive regulation of uterine smooth muscle contraction (GO:0070474)5.05917445
24positive regulation of gluconeogenesis (GO:0045722)4.99085198
25regulation of translational fidelity (GO:0006450)4.96873380
26cellular response to vitamin D (GO:0071305)4.90214647
27positive regulation of peptide hormone secretion (GO:0090277)4.78990504
28positive regulation of synaptic transmission, GABAergic (GO:0032230)4.75631609
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.75125672
30epithelial cell fate commitment (GO:0072148)4.72536835
31positive regulation of histone H3-K4 methylation (GO:0051571)4.68797947
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.63377286
33positive regulation of peptide secretion (GO:0002793)4.61230646
34protein autoprocessing (GO:0016540)4.60678109
35endocrine pancreas development (GO:0031018)4.56667874
36regulation of uterine smooth muscle contraction (GO:0070472)4.55823947
37regulation of RNA export from nucleus (GO:0046831)4.54474231
38production of molecular mediator involved in inflammatory response (GO:0002532)4.49142970
39regulation of histone H3-K4 methylation (GO:0051569)4.44944354
40regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)4.41711373
41regulation of penile erection (GO:0060405)4.39242139
42glandular epithelial cell development (GO:0002068)4.36899502
43DNA unwinding involved in DNA replication (GO:0006268)4.29940800
44purine nucleobase biosynthetic process (GO:0009113)4.23512329
45synapsis (GO:0007129)4.19297268
46type B pancreatic cell development (GO:0003323)4.18827265
47artery smooth muscle contraction (GO:0014824)4.11222478
48mitotic nuclear envelope disassembly (GO:0007077)4.08726089
49sequestering of metal ion (GO:0051238)4.04738834
50protein retention in ER lumen (GO:0006621)4.02881081
51DNA topological change (GO:0006265)4.00943796
52positive regulation of catecholamine secretion (GO:0033605)4.00474393
53cellular response to hepatocyte growth factor stimulus (GO:0035729)3.98173873
54response to hepatocyte growth factor (GO:0035728)3.98173873
55insulin secretion (GO:0030073)3.98063698
56detection of calcium ion (GO:0005513)3.97125328
57growth hormone secretion (GO:0030252)3.87258830
58formation of translation preinitiation complex (GO:0001731)3.84914680
59nucleobase biosynthetic process (GO:0046112)3.82801053
60regulation of insulin secretion (GO:0050796)3.82525845
61folic acid-containing compound biosynthetic process (GO:0009396)3.79484819
62positive regulation of amine transport (GO:0051954)3.78277658
63sister chromatid segregation (GO:0000819)3.77038542
64negative regulation of catenin import into nucleus (GO:0035414)3.76083086
65nuclear envelope disassembly (GO:0051081)3.74402565
66membrane disassembly (GO:0030397)3.74402565
67tRNA aminoacylation for protein translation (GO:0006418)3.74320681
68regulation of centriole replication (GO:0046599)3.73377516
69DNA replication initiation (GO:0006270)3.71684988
70negative regulation of hormone biosynthetic process (GO:0032353)3.71119304
71cellular response to glucagon stimulus (GO:0071377)3.68356835
72resolution of meiotic recombination intermediates (GO:0000712)3.66540209
73amino acid activation (GO:0043038)3.66005923
74tRNA aminoacylation (GO:0043039)3.66005923
75positive regulation of hormone secretion (GO:0046887)3.63160106
76regulation of histone H3-K27 methylation (GO:0061085)3.62482095
77mitotic sister chromatid segregation (GO:0000070)3.61099096
78maternal behavior (GO:0042711)3.58005952
79IMP biosynthetic process (GO:0006188)3.57853500
80cellular zinc ion homeostasis (GO:0006882)3.56729384
81regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.55705847
82ER to Golgi vesicle-mediated transport (GO:0006888)3.54324231
83response to pheromone (GO:0019236)3.51512567
84tonic smooth muscle contraction (GO:0014820)3.51247003
85columnar/cuboidal epithelial cell development (GO:0002066)3.51122228
86protoporphyrinogen IX metabolic process (GO:0046501)3.49512233
87vesicle coating (GO:0006901)3.49261508
88regulation of glucocorticoid secretion (GO:2000849)3.47905984
89DNA strand elongation involved in DNA replication (GO:0006271)3.46945456
90mitotic chromosome condensation (GO:0007076)3.46623047
91regulation of peptide hormone secretion (GO:0090276)3.45495030
92regulation of nucleobase-containing compound transport (GO:0032239)3.44658175
93meiotic chromosome segregation (GO:0045132)3.41756212
94definitive hemopoiesis (GO:0060216)3.38333661
95regulation of peptide secretion (GO:0002791)3.38236772
96tooth mineralization (GO:0034505)3.37451603
97nephron epithelium morphogenesis (GO:0072088)3.35403232
98nephron tubule morphogenesis (GO:0072078)3.35403232
99regulation of calcium ion-dependent exocytosis (GO:0017158)3.35376847
100suckling behavior (GO:0001967)3.34916210
101regulation of histone H3-K9 methylation (GO:0051570)3.32104838
102cellular response to vitamin (GO:0071295)3.32096250
103regulation of norepinephrine secretion (GO:0014061)3.31407943
104DNA strand elongation (GO:0022616)3.31225425
105peptide hormone secretion (GO:0030072)3.30995286
106intra-S DNA damage checkpoint (GO:0031573)3.27436059
107regulation of peptidyl-threonine phosphorylation (GO:0010799)3.26953160
108parental behavior (GO:0060746)3.26688022
109peptide secretion (GO:0002790)3.23430698
110peptide catabolic process (GO:0043171)3.23301698
111homocysteine metabolic process (GO:0050667)3.21581717
112activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.18693486
113response to lipoprotein particle (GO:0055094)3.16894328
114eating behavior (GO:0042755)3.16326931
115diterpenoid biosynthetic process (GO:0016102)3.16125745
116positive regulation of histone methylation (GO:0031062)3.15382550
117sensory perception of smell (GO:0007608)3.14771691
118regulation of histone methylation (GO:0031060)3.14757074
119regulation of centrosome cycle (GO:0046605)3.14463147
120regulation of translational elongation (GO:0006448)3.14392008
121sleep (GO:0030431)3.14178224
122regulation of systemic arterial blood pressure by hormone (GO:0001990)3.12738789
123regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.12738789
124endocrine process (GO:0050886)3.12738789
125regulation of hormone secretion (GO:0046883)3.12515151
126IMP metabolic process (GO:0046040)3.11455839
127negative regulation of hormone metabolic process (GO:0032351)3.11320548
128oxidative phosphorylation (GO:0006119)3.10599336
129regulation of vesicle fusion (GO:0031338)3.10204301
130membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.10174632
131positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.10053314
132protein localization to kinetochore (GO:0034501)3.07503847
133ER overload response (GO:0006983)3.07313777
134gland morphogenesis (GO:0022612)3.07094568
135tetrahydrofolate metabolic process (GO:0046653)3.07003535
136mitotic G2/M transition checkpoint (GO:0044818)3.06847725
137nitric oxide biosynthetic process (GO:0006809)3.06512678
138chemosensory behavior (GO:0007635)3.06410964
139astrocyte differentiation (GO:0048708)3.05593723
140regulation of calcium ion import (GO:0090279)3.05260346
141kinetochore organization (GO:0051383)3.04497650
142telomere maintenance via semi-conservative replication (GO:0032201)3.03908974
143prenylation (GO:0097354)3.03444206
144protein prenylation (GO:0018342)3.03444206
145pteridine-containing compound biosynthetic process (GO:0042559)3.02255912
146negative regulation of histone methylation (GO:0031061)3.01937303
147telomere maintenance via telomerase (GO:0007004)3.01898880
148regulation of corticosteroid hormone secretion (GO:2000846)2.99564649
149regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98702945
150positive regulation of nuclease activity (GO:0032075)2.98108154
151response to glucagon (GO:0033762)2.96178281
152protoporphyrinogen IX biosynthetic process (GO:0006782)2.95541230
153terpenoid biosynthetic process (GO:0016114)2.94979817
154pre-miRNA processing (GO:0031054)2.93440299
155ribosome assembly (GO:0042255)2.91892664
156mitotic recombination (GO:0006312)2.91076168
157viral mRNA export from host cell nucleus (GO:0046784)2.90359511
158peptide metabolic process (GO:0006518)2.90306833
159negative regulation of mitotic sister chromatid separation (GO:2000816)2.88578695
160negative regulation of sister chromatid segregation (GO:0033046)2.88578695
161negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88578695
162negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88578695
163negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88578695
164DNA synthesis involved in DNA repair (GO:0000731)2.88446134
165negative regulation of homotypic cell-cell adhesion (GO:0034111)2.88000639
166negative regulation of chromosome segregation (GO:0051985)2.87474359
167regulation of glucocorticoid metabolic process (GO:0031943)2.84676193
168erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.84629460
169L-phenylalanine catabolic process (GO:0006559)2.84629460
170DNA duplex unwinding (GO:0032508)2.83655593
171erythrocyte maturation (GO:0043249)2.82120318
172detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.82073461
173regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81929227
174DNA geometric change (GO:0032392)2.81872649
175mitotic sister chromatid cohesion (GO:0007064)2.81060917
176mitotic spindle checkpoint (GO:0071174)2.79790324
177telomere maintenance via recombination (GO:0000722)2.79327984
178intra-Golgi vesicle-mediated transport (GO:0006891)2.77573360
179somatic hypermutation of immunoglobulin genes (GO:0016446)2.76317926
180somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76317926
181chromosome segregation (GO:0007059)2.76222604
182regulation of mitotic spindle organization (GO:0060236)2.75634095
183mitotic spindle assembly checkpoint (GO:0007094)2.75561718
184cellular response to hexose stimulus (GO:0071331)2.75541376
185regulation of peptide transport (GO:0090087)2.75519845
186vitamin A metabolic process (GO:0006776)2.75225528
187centriole assembly (GO:0098534)2.75218781
188regulation of chromosome segregation (GO:0051983)2.74865526
189centriole replication (GO:0007099)2.73724592
190regulation of centrosome duplication (GO:0010824)2.73181836
191DNA conformation change (GO:0071103)2.73143872
192spindle assembly checkpoint (GO:0071173)2.70861148
193regulation of sister chromatid segregation (GO:0033045)2.69141506
194regulation of mitotic sister chromatid separation (GO:0010965)2.69141506
195regulation of mitotic sister chromatid segregation (GO:0033047)2.69141506
196negative regulation of translational initiation (GO:0045947)2.68239212
197positive regulation of DNA-dependent DNA replication (GO:2000105)2.67802938
198protein export from nucleus (GO:0006611)2.66793656
199protein localization to chromosome, centromeric region (GO:0071459)2.64923972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.03267564
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01386888
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69921407
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.55596170
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.06897853
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.82005826
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.79905045
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.78681336
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76092548
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.68866831
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68055254
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59905501
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43265310
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.40382158
15ELK1_19687146_ChIP-ChIP_HELA_Human2.38646530
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33357849
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.32110239
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30498551
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.29389564
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26739102
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25922552
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24287600
23YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17822886
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14476869
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13663320
26GATA1_22025678_ChIP-Seq_K562_Human2.10081562
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08527830
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05861264
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02701176
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.8920737
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99975203
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99290286
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.96604735
34IGF1R_20145208_ChIP-Seq_DFB_Human1.93885454
35TTF2_22483619_ChIP-Seq_HELA_Human1.91499611
36XRN2_22483619_ChIP-Seq_HELA_Human1.90650007
37VDR_23849224_ChIP-Seq_CD4+_Human1.88832472
38NCOR1_26117541_ChIP-Seq_K562_Human1.88468101
39DCP1A_22483619_ChIP-Seq_HELA_Human1.84343525
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.80895990
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.80668920
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80584213
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78952903
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.77830740
45FOXP3_21729870_ChIP-Seq_TREG_Human1.77802820
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77794243
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77745478
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.76821876
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75693544
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75671832
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74194769
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74088827
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73774192
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.72310175
55GATA1_19941826_ChIP-Seq_K562_Human1.71723887
56KDM5A_27292631_Chip-Seq_BREAST_Human1.71527829
57VDR_22108803_ChIP-Seq_LS180_Human1.70293652
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67383967
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65880131
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65427525
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63202783
62AR_21909140_ChIP-Seq_LNCAP_Human1.60583171
63REST_19997604_ChIP-ChIP_NEURONS_Mouse1.60503725
64GBX2_23144817_ChIP-Seq_PC3_Human1.54739387
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50379456
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45695371
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43667879
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42511412
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40547333
70EWS_26573619_Chip-Seq_HEK293_Human1.40530448
71REST_21632747_ChIP-Seq_MESCs_Mouse1.40390226
72GATA2_19941826_ChIP-Seq_K562_Human1.39315986
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36728870
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36509352
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.35983404
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35304536
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35288641
78* STAT3_23295773_ChIP-Seq_U87_Human1.33905639
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33470696
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33423401
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30822297
82TP53_22573176_ChIP-Seq_HFKS_Human1.29929975
83* SMAD4_21799915_ChIP-Seq_A2780_Human1.29369247
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27291105
85FOXA1_25552417_ChIP-Seq_VCAP_Human1.26662213
86GABP_19822575_ChIP-Seq_HepG2_Human1.24991161
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23674385
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22771149
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21323775
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20784515
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20752283
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20278029
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20050937
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.19107392
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.18897051
96MYC_18940864_ChIP-ChIP_HL60_Human1.18321561
97TFEB_21752829_ChIP-Seq_HELA_Human1.16982735
98NMYC_18555785_Chip-Seq_ESCs_Mouse1.16294985
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16287453
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.15982310
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14982533
102RNF2_27304074_Chip-Seq_NSC_Mouse1.14519011
103PHF8_20622853_ChIP-Seq_HELA_Human1.14293213
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13842372
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12531273
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12527721
107ERG_20517297_ChIP-Seq_VCAP_Human1.12077846
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12045256
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11518166
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11252390
111BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10713805
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10407692
113FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07805811
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05861857
115SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05449115
116RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04559174
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04500099
118ZNF263_19887448_ChIP-Seq_K562_Human1.04037890
119EZH2_27304074_Chip-Seq_ESCs_Mouse1.03936071
120EP300_21415370_ChIP-Seq_HL-1_Mouse1.03856645
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03847806
122KLF4_18555785_Chip-Seq_ESCs_Mouse1.03830608
123DROSHA_22980978_ChIP-Seq_HELA_Human1.03814678
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03437877
125TCF4_23295773_ChIP-Seq_U87_Human1.02811364
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01401756
127CIITA_25753668_ChIP-Seq_RAJI_Human1.01209279
128SOX2_16153702_ChIP-ChIP_HESCs_Human1.01151326
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01059612
130EZH2_27294783_Chip-Seq_ESCs_Mouse1.01034034
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99370553
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99333217
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99302920
134ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99058404
135AR_19668381_ChIP-Seq_PC3_Human0.98911853
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98518830
137PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98514789
138TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97892097
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97606086
140NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97498299
141CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97431965
142NFYB_21822215_ChIP-Seq_K562_Human0.97088275
143ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95897153
144CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95403446
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95288703
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94949278
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94686400
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94554454
149CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94459904
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94177743
151CHD1_26751641_Chip-Seq_LNCaP_Human0.93877244
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.93487577
153HNFA_21074721_ChIP-Seq_CACO-2_Human0.93481884
154RBPJ_21746931_ChIP-Seq_IB4_Human0.93001388
155ETV1_20927104_ChIP-Seq_GIST48_Human0.91792527
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91360870
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91206517
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91071247
159ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90953028
160PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.90929202
161P53_22387025_ChIP-Seq_ESCs_Mouse0.90679383
162FOXA2_19822575_ChIP-Seq_HepG2_Human0.90557507
163GATA6_21074721_ChIP-Seq_CACO-2_Human0.90512618
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.90335507
165STAT3_18555785_Chip-Seq_ESCs_Mouse0.90321148
166ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90192855
167ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89100433
168SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88931093
169SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88264488
170SMAD4_21741376_ChIP-Seq_HESCs_Human0.88023207
171DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87887342
172NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87037188
173LXR_22158963_ChIP-Seq_LIVER_Mouse0.86897485
174PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86881799
175NANOG_16153702_ChIP-ChIP_HESCs_Human0.86796014
176HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86646786
177RARB_27405468_Chip-Seq_BRAIN_Mouse0.86592646
178SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86106559
179SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85759084
180ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85410980
181GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84454048
182KDM2B_26808549_Chip-Seq_REH_Human0.84128322
183CBX2_22325352_ChIP-Seq_293T-Rex_Human0.83868598
184FUS_26573619_Chip-Seq_HEK293_Human0.83613795
185SMAD1_18555785_Chip-Seq_ESCs_Mouse0.83352851
186FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.83278432
187CTCF_18555785_Chip-Seq_ESCs_Mouse0.82698719
188NFYA_21822215_ChIP-Seq_K562_Human0.82064425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue6.66475546
2MP0003195_calcinosis5.77993356
3MP0005379_endocrine/exocrine_gland_phen4.81417802
4MP0003183_abnormal_peptide_metabolism4.58318234
5MP0002837_dystrophic_cardiac_calcinosis4.39098851
6MP0008057_abnormal_DNA_replication4.13153847
7MP0004147_increased_porphyrin_level3.90907320
8MP0005645_abnormal_hypothalamus_physiol3.49592538
9MP0008058_abnormal_DNA_repair3.46524831
10MP0000003_abnormal_adipose_tissue3.43630602
11MP0002909_abnormal_adrenal_gland3.42985088
12MP0010094_abnormal_chromosome_stability3.37618805
13MP0004957_abnormal_blastocyst_morpholog3.31393446
14MP0008995_early_reproductive_senescence3.14357668
15MP0001944_abnormal_pancreas_morphology3.00787779
16MP0003111_abnormal_nucleus_morphology2.96256370
17MP0000678_abnormal_parathyroid_gland2.92751466
18MP0003693_abnormal_embryo_hatching2.73715334
19MP0002638_abnormal_pupillary_reflex2.69482157
20MP0005084_abnormal_gallbladder_morpholo2.67309360
21MP0002163_abnormal_gland_morphology2.63797661
22MP0004270_analgesia2.63735980
23MP0002877_abnormal_melanocyte_morpholog2.60474235
24MP0010386_abnormal_urinary_bladder2.45171965
25MP0002138_abnormal_hepatobiliary_system2.43032221
26MP0003941_abnormal_skin_development2.35578648
27MP0008007_abnormal_cellular_replicative2.32212014
28MP0002693_abnormal_pancreas_physiology2.28821924
29MP0004043_abnormal_pH_regulation2.26250125
30MP0003786_premature_aging2.20321948
31MP0003077_abnormal_cell_cycle2.12127297
32MP0002102_abnormal_ear_morphology2.11326085
33MP0008932_abnormal_embryonic_tissue2.11140666
34MP0003656_abnormal_erythrocyte_physiolo2.10707386
35MP0002234_abnormal_pharynx_morphology2.05516964
36MP0001765_abnormal_ion_homeostasis2.01265768
37MP0005365_abnormal_bile_salt1.98302428
38MP0008775_abnormal_heart_ventricle1.91808889
39MP0001529_abnormal_vocalization1.88010044
40MP0010307_abnormal_tumor_latency1.87287601
41MP0001661_extended_life_span1.85814243
42MP0003122_maternal_imprinting1.79041913
43MP0003718_maternal_effect1.78375818
44MP0001986_abnormal_taste_sensitivity1.77629987
45MP0006072_abnormal_retinal_apoptosis1.75779937
46MP0001756_abnormal_urination1.75454968
47MP0005220_abnormal_exocrine_pancreas1.73060758
48MP0003787_abnormal_imprinting1.69728505
49MP0003890_abnormal_embryonic-extraembry1.67735446
50MP0002734_abnormal_mechanical_nocicepti1.62533139
51MP0006035_abnormal_mitochondrial_morpho1.62472297
52MP0001730_embryonic_growth_arrest1.61514299
53MP0003984_embryonic_growth_retardation1.60891714
54MP0005375_adipose_tissue_phenotype1.60750537
55MP0002078_abnormal_glucose_homeostasis1.60568586
56MP0001697_abnormal_embryo_size1.60022153
57MP0005083_abnormal_biliary_tract1.58451513
58MP0001672_abnormal_embryogenesis/_devel1.57943835
59MP0005380_embryogenesis_phenotype1.57943835
60MP0002088_abnormal_embryonic_growth/wei1.57137734
61MP0005257_abnormal_intraocular_pressure1.55178252
62MP0002139_abnormal_hepatobiliary_system1.49150851
63MP0004019_abnormal_vitamin_homeostasis1.47186073
64MP0003937_abnormal_limbs/digits/tail_de1.47045002
65MP0004215_abnormal_myocardial_fiber1.45751242
66MP0009780_abnormal_chondrocyte_physiolo1.43714677
67MP0002396_abnormal_hematopoietic_system1.43137105
68MP0006036_abnormal_mitochondrial_physio1.40140886
69MP0005397_hematopoietic_system_phenotyp1.39108570
70MP0001545_abnormal_hematopoietic_system1.39108570
71MP0010352_gastrointestinal_tract_polyps1.38130472
72MP0005451_abnormal_body_composition1.36850742
73MP0002084_abnormal_developmental_patter1.35074092
74MP0005670_abnormal_white_adipose1.33982334
75MP0004264_abnormal_extraembryonic_tissu1.33799250
76MP0002751_abnormal_autonomic_nervous1.33211543
77MP0000350_abnormal_cell_proliferation1.31458572
78MP0003567_abnormal_fetal_cardiomyocyte1.29828096
79MP0009672_abnormal_birth_weight1.28066078
80MP0002080_prenatal_lethality1.26631806
81MP0003959_abnormal_lean_body1.26601628
82MP0005636_abnormal_mineral_homeostasis1.23469423
83MP0002086_abnormal_extraembryonic_tissu1.22803826
84MP0001929_abnormal_gametogenesis1.21813170
85MP0001502_abnormal_circadian_rhythm1.21506260
86MP0008961_abnormal_basal_metabolism1.20142010
87MP0003121_genomic_imprinting1.18966807
88MP0006292_abnormal_olfactory_placode1.18727229
89MP0003300_gastrointestinal_ulcer1.18447467
90MP0002009_preneoplasia1.16006414
91MP0002132_abnormal_respiratory_system1.15187479
92MP0000313_abnormal_cell_death1.15138138
93MP0002896_abnormal_bone_mineralization1.14938326
94MP0002210_abnormal_sex_determination1.12837861
95MP0000613_abnormal_salivary_gland1.12307212
96MP0003385_abnormal_body_wall1.08768993
97MP0003950_abnormal_plasma_membrane1.07134930
98MP0002085_abnormal_embryonic_tissue1.06768143
99MP0009703_decreased_birth_body1.06758654
100MP0002168_other_aberrant_phenotype1.06452323
101MP0000639_abnormal_adrenal_gland1.05299076
102MP0002733_abnormal_thermal_nociception1.04542829
103MP0004197_abnormal_fetal_growth/weight/1.04248950
104MP0005408_hypopigmentation1.01751500
105MP0001145_abnormal_male_reproductive0.99231411
106MP0000631_abnormal_neuroendocrine_gland0.99079061
107MP0004145_abnormal_muscle_electrophysio0.99062110
108MP0003953_abnormal_hormone_level0.98958705
109MP0000230_abnormal_systemic_arterial0.97932673
110MP0002938_white_spotting0.95588926
111MP0005058_abnormal_lysosome_morphology0.94580879
112MP0000653_abnormal_sex_gland0.91185454
113MP0003806_abnormal_nucleotide_metabolis0.91069255
114MP0000358_abnormal_cell_content/0.90273345
115MP0004808_abnormal_hematopoietic_stem0.89474954
116MP0003172_abnormal_lysosome_physiology0.89450112
117MP0003252_abnormal_bile_duct0.88455158
118MP0002928_abnormal_bile_duct0.86485195
119MP0009643_abnormal_urine_homeostasis0.85002374
120MP0001970_abnormal_pain_threshold0.84314963
121MP0003698_abnormal_male_reproductive0.84242248
122MP0002184_abnormal_innervation0.79095001
123MP0003283_abnormal_digestive_organ0.78727029
124MP0001905_abnormal_dopamine_level0.78681209
125MP0001727_abnormal_embryo_implantation0.77334214
126MP0010630_abnormal_cardiac_muscle0.76795692
127MP0002735_abnormal_chemical_nociception0.76524433
128MP0001270_distended_abdomen0.74979178
129MP0003868_abnormal_feces_composition0.74795058
130MP0005330_cardiomyopathy0.74126555
131MP0000462_abnormal_digestive_system0.73938043
132MP0008770_decreased_survivor_rate0.73704656
133MP0003186_abnormal_redox_activity0.73596783
134MP0002249_abnormal_larynx_morphology0.71880831
135MP0002160_abnormal_reproductive_system0.71159463
136MP0005535_abnormal_body_temperature0.70875104
137MP0003123_paternal_imprinting0.68638267
138MP0000266_abnormal_heart_morphology0.67617542
139MP0001293_anophthalmia0.67577645
140MP0010234_abnormal_vibrissa_follicle0.67178611
141MP0003137_abnormal_impulse_conducting0.66673293
142MP0003045_fibrosis0.65408667
143MP0005410_abnormal_fertilization0.64515451
144MP0002019_abnormal_tumor_incidence0.64456847
145MP0004134_abnormal_chest_morphology0.64215369
146MP0002177_abnormal_outer_ear0.64167225
147MP0003699_abnormal_female_reproductive0.63869679
148MP0001666_abnormal_nutrient_absorption0.63755421
149MP0002269_muscular_atrophy0.62971681
150MP0004510_myositis0.61481199
151MP0005395_other_phenotype0.61216309
152MP0003879_abnormal_hair_cell0.61139726
153MP0002572_abnormal_emotion/affect_behav0.60556052
154MP0005253_abnormal_eye_physiology0.57591407
155MP0001299_abnormal_eye_distance/0.57582529
156MP0003633_abnormal_nervous_system0.57393224
157MP0005448_abnormal_energy_balance0.56437478
158MP0005332_abnormal_amino_acid0.54694719
159MP0009697_abnormal_copulation0.53856694
160MP0000538_abnormal_urinary_bladder0.53643705
161MP0004085_abnormal_heartbeat0.51237146
162MP0000516_abnormal_urinary_system0.50359681
163MP0005367_renal/urinary_system_phenotyp0.50359681
164MP0002127_abnormal_cardiovascular_syste0.50158353
165MP0002557_abnormal_social/conspecific_i0.49991354
166MP0008877_abnormal_DNA_methylation0.49884497
167MP0003119_abnormal_digestive_system0.48366378
168MP0004036_abnormal_muscle_relaxation0.47242145
169MP0004084_abnormal_cardiac_muscle0.46658943
170MP0002069_abnormal_eating/drinking_beha0.46639897
171MP0005075_abnormal_melanosome_morpholog0.45889681
172MP0005452_abnormal_adipose_tissue0.43137233
173MP0000955_abnormal_spinal_cord0.41333250
174MP0004924_abnormal_behavior0.41182846

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)8.70085929
2Hyperinsulinemic hypoglycemia (HP:0000825)6.89644958
3Hyperglycemia (HP:0003074)6.58576193
4Abnormality of calcium-phosphate metabolism (HP:0100530)6.44516324
5Hypoglycemic seizures (HP:0002173)5.73929703
6Pancreatic islet-cell hyperplasia (HP:0004510)5.42976091
7Abnormality of the pancreatic islet cells (HP:0006476)5.21730491
8Abnormality of endocrine pancreas physiology (HP:0012093)5.21730491
9Truncus arteriosus (HP:0001660)5.06442360
10Late onset (HP:0003584)5.03710527
11Symptomatic seizures (HP:0011145)4.90871970
12Orthostatic hypotension (HP:0001278)4.82909673
13Hypoglycemic coma (HP:0001325)4.78309724
14Large for gestational age (HP:0001520)4.67163379
15Hyperthyroidism (HP:0000836)4.48559908
16Ketoacidosis (HP:0001993)4.33094643
17Dysautonomia (HP:0002459)4.32703080
18Chromsome breakage (HP:0040012)4.30191779
19Abnormal gallbladder physiology (HP:0012438)4.20491762
20Cholecystitis (HP:0001082)4.20491762
21Insulin-resistant diabetes mellitus (HP:0000831)4.06370604
22Chromosomal breakage induced by crosslinking agents (HP:0003221)4.03460018
23Birth length less than 3rd percentile (HP:0003561)3.90864563
24Hyperphosphatemia (HP:0002905)3.84537804
25Agitation (HP:0000713)3.84290796
26Papilledema (HP:0001085)3.73929441
27Abnormality of homocysteine metabolism (HP:0010919)3.64213243
28Homocystinuria (HP:0002156)3.64213243
29Hyperparathyroidism (HP:0000843)3.59758882
30Increased circulating renin level (HP:0000848)3.50732846
31Ankyloglossia (HP:0010296)3.46276700
32Hemiparesis (HP:0001269)3.45745140
33Reticulocytosis (HP:0001923)3.38002428
34Hypotension (HP:0002615)3.30741552
35Hyperkalemia (HP:0002153)3.19909143
36Acute myeloid leukemia (HP:0004808)3.18769076
37Prominent metopic ridge (HP:0005487)3.17655423
38Abnormality of reticulocytes (HP:0004312)3.16498679
39Acanthocytosis (HP:0001927)3.14238836
40Increased CSF protein (HP:0002922)3.11003742
41Dysostosis multiplex (HP:0000943)3.08735991
42Retinal atrophy (HP:0001105)3.02049132
43Decreased circulating renin level (HP:0003351)2.99328360
44Abnormality of renin-angiotensin system (HP:0000847)2.91402980
45Poikilocytosis (HP:0004447)2.87085932
46Abnormality of potassium homeostasis (HP:0011042)2.83668185
47Abnormality of the metopic suture (HP:0005556)2.80072215
48Abnormality of chromosome stability (HP:0003220)2.78049914
49Small intestinal stenosis (HP:0012848)2.77368986
50Duodenal stenosis (HP:0100867)2.77368986
51Hypokalemia (HP:0002900)2.76676710
52Unilateral renal agenesis (HP:0000122)2.76655981
53Bowel incontinence (HP:0002607)2.73801365
54Abnormality of cochlea (HP:0000375)2.72566049
55Reticulocytopenia (HP:0001896)2.71101876
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.70731468
57Abnormality of the preputium (HP:0100587)2.69406473
58Abnormal pancreas size (HP:0012094)2.68476926
59Insulin resistance (HP:0000855)2.65742250
60Menstrual irregularities (HP:0000858)2.65381809
61Abnormality of the heme biosynthetic pathway (HP:0010472)2.63239464
62Intestinal atresia (HP:0011100)2.61949911
63Palpitations (HP:0001962)2.61514887
64Abnormal large intestine physiology (HP:0012700)2.59757338
65Abnormality of vitamin B metabolism (HP:0004340)2.59345543
66Cortical dysplasia (HP:0002539)2.56808143
67Abnormality of the intrinsic pathway (HP:0010989)2.51842378
68Duplicated collecting system (HP:0000081)2.51189123
69Right ventricular cardiomyopathy (HP:0011663)2.46270033
70EEG with generalized epileptiform discharges (HP:0011198)2.42682680
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.40134351
72Abnormality of chloride homeostasis (HP:0011422)2.38516217
73Conjugated hyperbilirubinemia (HP:0002908)2.38091973
74Restlessness (HP:0000711)2.37918262
75Hypsarrhythmia (HP:0002521)2.36451314
76Ileus (HP:0002595)2.35910636
77Papillary thyroid carcinoma (HP:0002895)2.35225404
78Abnormal autonomic nervous system physiology (HP:0012332)2.34400197
79Epileptiform EEG discharges (HP:0011182)2.32299173
80Gout (HP:0001997)2.32250641
81Myelodysplasia (HP:0002863)2.32211571
82Abnormality of the duodenum (HP:0002246)2.31954919
83Abnormality of methionine metabolism (HP:0010901)2.31803166
84Aplasia/Hypoplasia of the earlobes (HP:0009906)2.31243434
85Hypoparathyroidism (HP:0000829)2.29399948
86Abnormality of glycolysis (HP:0004366)2.29386229
87Polycythemia (HP:0001901)2.29373310
88Abnormality of oral frenula (HP:0000190)2.28967450
89Long toe (HP:0010511)2.28335537
90Abnormality of vitamin metabolism (HP:0100508)2.27952119
91Abnormality of the renal collecting system (HP:0004742)2.27895451
92Tetany (HP:0001281)2.27699253
93Abnormal gallbladder morphology (HP:0012437)2.25970949
94Type II lissencephaly (HP:0007260)2.22999947
95Pallor (HP:0000980)2.19936954
96Abnormality of sulfur amino acid metabolism (HP:0004339)2.19918171
97Growth hormone excess (HP:0000845)2.19829275
98Hypophosphatemia (HP:0002148)2.18512300
99Generalized hyperpigmentation (HP:0007440)2.17660316
100Hyperbilirubinemia (HP:0002904)2.17197833
101Thyroid carcinoma (HP:0002890)2.16342528
102Hyperphosphaturia (HP:0003109)2.16298372
103Blue irides (HP:0000635)2.16144818
104Hypercortisolism (HP:0001578)2.15769706
105Seborrheic dermatitis (HP:0001051)2.15677715
106Abnormality of the fovea (HP:0000493)2.13668996
107Increased serum pyruvate (HP:0003542)2.11499849
108Hypoplasia of the fovea (HP:0007750)2.11311647
109Aplasia/Hypoplasia of the fovea (HP:0008060)2.11311647
110Neoplasm of the small intestine (HP:0100833)2.10409614
111Hypertensive crisis (HP:0100735)2.07287038
112Abnormality of the vitreous humor (HP:0004327)2.06960574
113Anteriorly placed anus (HP:0001545)2.06481306
114Pheochromocytoma (HP:0002666)2.05498661
115Sandal gap (HP:0001852)2.04902729
116Abnormality of DNA repair (HP:0003254)2.02661940
117Meckel diverticulum (HP:0002245)2.01183557
118Short middle phalanx of the 5th finger (HP:0004220)2.00666682
119Ketosis (HP:0001946)2.00319074
120Abnormality of the labia minora (HP:0012880)2.00161186
121Rhabdomyosarcoma (HP:0002859)1.99926808
122Increased nuchal translucency (HP:0010880)1.99524448
123Overlapping toe (HP:0001845)1.98172409
124Embryonal renal neoplasm (HP:0011794)1.97758165
125Abnormal hemoglobin (HP:0011902)1.97639507
126Striae distensae (HP:0001065)1.97170126
127Acute encephalopathy (HP:0006846)1.96228565
128Abnormality of the tricuspid valve (HP:0001702)1.95476128
129Mucopolysacchariduria (HP:0008155)1.94555402
130Urinary glycosaminoglycan excretion (HP:0003541)1.94555402
131Sloping forehead (HP:0000340)1.94360605
132Nephroblastoma (Wilms tumor) (HP:0002667)1.94096830
133Exocrine pancreatic insufficiency (HP:0001738)1.92872210
134Abnormal lung lobation (HP:0002101)1.92834710
135Hypothermia (HP:0002045)1.92750419
136Abnormality of renal resorption (HP:0011038)1.92690494
137Cholelithiasis (HP:0001081)1.92620308
138Angiofibromas (HP:0010615)1.90116941
139Adenoma sebaceum (HP:0009720)1.90116941
140Abnormality of the right ventricle (HP:0001707)1.90020813
141Abnormality of the ileum (HP:0001549)1.89597662
142Macroorchidism (HP:0000053)1.88953728
143Turricephaly (HP:0000262)1.88771427
144Septate vagina (HP:0001153)1.87907328
145Aplasia/hypoplasia of the uterus (HP:0008684)1.86241802
146Progressive neurologic deterioration (HP:0002344)1.85149738
147Upper limb muscle weakness (HP:0003484)1.84930763
148Microvesicular hepatic steatosis (HP:0001414)1.83937360
149Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83886009
150Abnormality of polysaccharide metabolism (HP:0011012)1.83886009
151Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83886009
152Acute necrotizing encephalopathy (HP:0006965)1.82817240
153Horseshoe kidney (HP:0000085)1.82621781
154Hypomagnesemia (HP:0002917)1.80453611
155Neoplasm of the heart (HP:0100544)1.80360779
156Abnormally folded helix (HP:0008544)1.80197933
157Abnormal drinking behavior (HP:0030082)1.79899218
158Polydipsia (HP:0001959)1.79899218
159Progressive macrocephaly (HP:0004481)1.78265331
160Limb hypertonia (HP:0002509)1.78096334
161Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77748147
162Erectile abnormalities (HP:0100639)1.77159253
163Morphological abnormality of the inner ear (HP:0011390)1.76059888
164Abnormal mitochondria in muscle tissue (HP:0008316)1.75994797
165Cerebral edema (HP:0002181)1.75641816
166Tachypnea (HP:0002789)1.75163551
167Increased hepatocellular lipid droplets (HP:0006565)1.74417730
168Cafe-au-lait spot (HP:0000957)1.72635133
169Posterior subcapsular cataract (HP:0007787)1.71723199
170Abnormality of the gallbladder (HP:0005264)1.71289699
171Congenital glaucoma (HP:0001087)1.71184115
172Neuroendocrine neoplasm (HP:0100634)1.71001316
173Abnormality of magnesium homeostasis (HP:0004921)1.70566646
174Skin nodule (HP:0200036)1.69028462
175Acute lymphatic leukemia (HP:0006721)1.68920546
176Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68781454
177Hypoplasia of the uterus (HP:0000013)1.67666995
178Osteomalacia (HP:0002749)1.66021050
179Protruding tongue (HP:0010808)1.65611122
180Lipid accumulation in hepatocytes (HP:0006561)1.65419501
181Metaphyseal irregularity (HP:0003025)1.64820434
182Macrocytic anemia (HP:0001972)1.64721678
183Ependymoma (HP:0002888)1.64521241
184Hypoplastic labia majora (HP:0000059)1.63906016
185Atelectasis (HP:0100750)1.63891791
186Abnormality of glycolipid metabolism (HP:0010969)1.63711759
187Abnormality of glycosphingolipid metabolism (HP:0004343)1.63711759

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK37.86290807
2PIK3CG6.02919196
3MAPK156.01383819
4WNK45.01792821
5TTK3.73273605
6UHMK13.44967009
7EIF2AK13.39288967
8TAOK33.33278591
9PRKD33.16885210
10PKN23.04700957
11INSRR2.89771418
12OBSCN2.81096196
13CDC72.68139644
14FRK2.65771458
15RIPK42.55508271
16MAP3K22.39661134
17FLT32.23004330
18WNK12.08973231
19TSSK62.07673971
20PBK1.95498464
21TNIK1.87627578
22MST41.86521507
23CLK11.75728249
24BUB11.73059411
25WEE11.70616518
26KSR21.68618187
27PLK31.65580517
28STK31.65173845
29HIPK21.62100099
30SRPK11.56460013
31EEF2K1.54379056
32CCNB11.52465474
33NEK11.50527846
34ZAK1.48227488
35PRKD21.48108534
36NEK21.31410654
37CAMKK21.31297272
38MKNK11.31055545
39NUAK11.27226282
40MAP3K11.26366521
41PAK31.24044249
42ATR1.23177463
43NME11.23046163
44CHEK21.21242672
45SCYL21.19035670
46PRKG21.14649474
47BRAF1.12499341
48ATM1.12292034
49RPS6KB21.09536384
50BRD41.08141552
51PLK11.02482602
52PDK21.01472089
53DYRK1B1.01156013
54TRPM70.99076558
55STK40.97045504
56BMX0.96968416
57EIF2AK30.96699304
58BRSK20.93552633
59CHEK10.93459598
60ALK0.92899432
61DMPK0.90533368
62MKNK20.89629602
63STK160.89215174
64BCKDK0.87706132
65TEC0.86620944
66MAP3K90.85373735
67YES10.85287283
68ERN10.83009757
69ERBB40.82368806
70PRKCH0.79545651
71MAP3K80.78716742
72NTRK30.78477602
73PAK60.76399608
74MAPKAPK30.75010654
75CDK10.73973271
76FGFR10.73276962
77FGFR20.71549237
78LATS10.70240558
79ARAF0.69333150
80NLK0.67511338
81GRK70.67123789
82CDK20.64322473
83EPHA30.62004823
84PRKAA10.60405851
85RIPK10.58971505
86CSNK1E0.58579257
87EPHA20.55114938
88AURKB0.54527514
89FGFR30.54458451
90ACVR1B0.53011220
91CSNK2A20.52521820
92KSR10.52237393
93AKT30.50865823
94RPS6KA40.50392250
95NTRK10.49569763
96ITK0.48716943
97EIF2AK20.47239934
98CAMK1D0.47063365
99PLK40.44747296
100CAMK2D0.44098727
101MAP4K20.43667939
102MARK20.43575188
103CDK120.42433980
104SGK2230.41652028
105SGK4940.41652028
106PTK20.41290579
107PRKD10.40439147
108RAF10.40054321
109PDPK10.39634575
110JAK20.39065922
111PTK60.38576535
112MAPK130.38079661
113GSK3B0.37766655
114MAP3K130.37099776
115DYRK1A0.37071777
116CAMK1G0.36066133
117PRKAA20.35630670
118CDC42BPA0.34957750
119IRAK30.34799847
120CSNK1A1L0.34524303
121SGK10.34129391
122DAPK20.33370782
123MAPK140.33314756
124RET0.33044835
125STK38L0.32829081
126PLK20.32491031
127VRK10.32099042
128PIM10.31259669
129BMPR1B0.31060299
130CSNK2A10.30683864
131DAPK10.30383910
132MAPKAPK50.29997603
133DYRK20.29425246
134PAK10.29418817
135CSK0.29248592
136MTOR0.27648598
137MAP3K40.27600673
138PASK0.27367102
139DYRK30.26284422
140SGK20.26270989
141CDK50.25273958
142CAMK2B0.25146511
143MAPK100.24913881
144RPS6KA30.24763345
145ILK0.24342315
146FER0.24167142
147PRKDC0.21283053
148PDK10.20889307
149MAP2K10.20387526
150TAOK10.20376227
151PRKG10.18023115
152IRAK10.17968762
153PRKCG0.17916848
154CSNK1A10.17761087
155BCR0.17301340
156BRSK10.17212709
157PRKACA0.17154519
158PRKCA0.17024437
159CAMK2A0.16567979
160MOS0.16444062
161PRKCI0.15396740
162PRKCE0.14997419
163JAK10.14589882
164BMPR20.14393949
165RPS6KA10.14116937
166PRKACG0.13649331
167ADRBK10.13366709
168RPS6KA50.13112021
169SGK30.12702917

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.95682246
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.16993764
3Insulin secretion_Homo sapiens_hsa049113.95900581
4Protein export_Homo sapiens_hsa030603.95634215
5One carbon pool by folate_Homo sapiens_hsa006703.22233999
6Homologous recombination_Homo sapiens_hsa034403.21867190
7Mismatch repair_Homo sapiens_hsa034303.19848483
8Type I diabetes mellitus_Homo sapiens_hsa049403.07284729
9DNA replication_Homo sapiens_hsa030302.83699026
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.70843345
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63825113
12Circadian rhythm_Homo sapiens_hsa047102.56950682
13RNA transport_Homo sapiens_hsa030132.56650739
14Fanconi anemia pathway_Homo sapiens_hsa034602.37902084
15Non-homologous end-joining_Homo sapiens_hsa034502.31699346
16Type II diabetes mellitus_Homo sapiens_hsa049302.06883995
17Cell cycle_Homo sapiens_hsa041101.98992862
18Nucleotide excision repair_Homo sapiens_hsa034201.86566030
19Spliceosome_Homo sapiens_hsa030401.86024132
20Propanoate metabolism_Homo sapiens_hsa006401.82815333
21Basal transcription factors_Homo sapiens_hsa030221.82040183
22Prion diseases_Homo sapiens_hsa050201.81123928
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78970067
24Glucagon signaling pathway_Homo sapiens_hsa049221.69489112
25Pyruvate metabolism_Homo sapiens_hsa006201.67237373
26Vibrio cholerae infection_Homo sapiens_hsa051101.64717536
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.64434994
28Selenocompound metabolism_Homo sapiens_hsa004501.63565622
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62561493
30Steroid biosynthesis_Homo sapiens_hsa001001.62397040
31Amphetamine addiction_Homo sapiens_hsa050311.59190123
32Cocaine addiction_Homo sapiens_hsa050301.57235264
33Sulfur metabolism_Homo sapiens_hsa009201.56654168
34Ribosome_Homo sapiens_hsa030101.56095774
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52785942
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49996590
37RNA polymerase_Homo sapiens_hsa030201.48367397
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45751989
39mRNA surveillance pathway_Homo sapiens_hsa030151.45450148
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.43290312
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42268240
42Thyroid hormone synthesis_Homo sapiens_hsa049181.40831783
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40777897
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37017660
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36278728
46Circadian entrainment_Homo sapiens_hsa047131.29661383
47Dopaminergic synapse_Homo sapiens_hsa047281.29381443
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28542306
49Linoleic acid metabolism_Homo sapiens_hsa005911.25856935
50Dorso-ventral axis formation_Homo sapiens_hsa043201.24961354
51Estrogen signaling pathway_Homo sapiens_hsa049151.21932306
52Carbon metabolism_Homo sapiens_hsa012001.20954882
53Regulation of autophagy_Homo sapiens_hsa041401.19300559
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.17810563
55Base excision repair_Homo sapiens_hsa034101.16738215
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13311602
57Lysosome_Homo sapiens_hsa041421.12933857
58GABAergic synapse_Homo sapiens_hsa047271.12079846
59Oxidative phosphorylation_Homo sapiens_hsa001901.11582472
60Oocyte meiosis_Homo sapiens_hsa041141.09145351
61Serotonergic synapse_Homo sapiens_hsa047261.09138582
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08930817
63Purine metabolism_Homo sapiens_hsa002301.08592785
64Biosynthesis of amino acids_Homo sapiens_hsa012301.07584893
65Renin secretion_Homo sapiens_hsa049241.07187695
66Pancreatic secretion_Homo sapiens_hsa049721.05674717
67ABC transporters_Homo sapiens_hsa020101.02926033
68N-Glycan biosynthesis_Homo sapiens_hsa005101.01149980
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00342962
70Cholinergic synapse_Homo sapiens_hsa047250.99485718
71Folate biosynthesis_Homo sapiens_hsa007900.99034958
72Vitamin B6 metabolism_Homo sapiens_hsa007500.98418772
73Long-term potentiation_Homo sapiens_hsa047200.94612853
74Pyrimidine metabolism_Homo sapiens_hsa002400.93383171
75Fructose and mannose metabolism_Homo sapiens_hsa000510.92601294
76Parkinsons disease_Homo sapiens_hsa050120.92028837
77Fatty acid metabolism_Homo sapiens_hsa012120.91044159
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90278610
79Ovarian steroidogenesis_Homo sapiens_hsa049130.89463162
80Other glycan degradation_Homo sapiens_hsa005110.89110197
81Ether lipid metabolism_Homo sapiens_hsa005650.87971661
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86780208
83Long-term depression_Homo sapiens_hsa047300.86453266
84GnRH signaling pathway_Homo sapiens_hsa049120.86339055
85Synaptic vesicle cycle_Homo sapiens_hsa047210.83252317
86Fatty acid elongation_Homo sapiens_hsa000620.82832298
87Taste transduction_Homo sapiens_hsa047420.80709824
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78035956
89Glutamatergic synapse_Homo sapiens_hsa047240.77115220
90Proteasome_Homo sapiens_hsa030500.75777644
91cAMP signaling pathway_Homo sapiens_hsa040240.75643545
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75372264
93Huntingtons disease_Homo sapiens_hsa050160.73265705
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71527820
95Oxytocin signaling pathway_Homo sapiens_hsa049210.70204728
96Protein digestion and absorption_Homo sapiens_hsa049740.68873492
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66988944
98Arginine biosynthesis_Homo sapiens_hsa002200.65092346
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64962955
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64797481
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64603602
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62275936
103Lysine degradation_Homo sapiens_hsa003100.62139157
104RNA degradation_Homo sapiens_hsa030180.61697108
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.60378310
106mTOR signaling pathway_Homo sapiens_hsa041500.59439725
107Renal cell carcinoma_Homo sapiens_hsa052110.58607783
108Bladder cancer_Homo sapiens_hsa052190.58118757
109Butanoate metabolism_Homo sapiens_hsa006500.57324545
110Cardiac muscle contraction_Homo sapiens_hsa042600.56087332
111Prolactin signaling pathway_Homo sapiens_hsa049170.55931170
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55834890
113Metabolic pathways_Homo sapiens_hsa011000.55391861
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54074621
115Morphine addiction_Homo sapiens_hsa050320.53920638
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53637400
117Renin-angiotensin system_Homo sapiens_hsa046140.53344876
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51778883
119Insulin signaling pathway_Homo sapiens_hsa049100.51118131
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50769794
121Inositol phosphate metabolism_Homo sapiens_hsa005620.50739789
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48684955
123Thyroid cancer_Homo sapiens_hsa052160.48421737
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47073506
125Gastric acid secretion_Homo sapiens_hsa049710.45579505
126Gap junction_Homo sapiens_hsa045400.45473327
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44350310
128Fat digestion and absorption_Homo sapiens_hsa049750.42282568
129Alzheimers disease_Homo sapiens_hsa050100.42166574
130Alcoholism_Homo sapiens_hsa050340.42041443
131HIF-1 signaling pathway_Homo sapiens_hsa040660.41720177
132Collecting duct acid secretion_Homo sapiens_hsa049660.41250223
133Melanogenesis_Homo sapiens_hsa049160.40986288
134Pentose phosphate pathway_Homo sapiens_hsa000300.40612047
135Sphingolipid metabolism_Homo sapiens_hsa006000.40549994
136TGF-beta signaling pathway_Homo sapiens_hsa043500.39031263
137Acute myeloid leukemia_Homo sapiens_hsa052210.38398461
138Salivary secretion_Homo sapiens_hsa049700.37576909
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34399518
140Glutathione metabolism_Homo sapiens_hsa004800.33681958
141Olfactory transduction_Homo sapiens_hsa047400.32714837
142Arachidonic acid metabolism_Homo sapiens_hsa005900.32500959
143Insulin resistance_Homo sapiens_hsa049310.32256313
144Dilated cardiomyopathy_Homo sapiens_hsa054140.31699046
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30235646
146ErbB signaling pathway_Homo sapiens_hsa040120.29335646
147MicroRNAs in cancer_Homo sapiens_hsa052060.27273578
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26735269
149Chronic myeloid leukemia_Homo sapiens_hsa052200.26483782
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26240593
151Wnt signaling pathway_Homo sapiens_hsa043100.25889425
152Ras signaling pathway_Homo sapiens_hsa040140.25227464
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25112447
154p53 signaling pathway_Homo sapiens_hsa041150.24583635
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24513825
156Viral carcinogenesis_Homo sapiens_hsa052030.24301980
157Calcium signaling pathway_Homo sapiens_hsa040200.24141991
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.22139824
159Endometrial cancer_Homo sapiens_hsa052130.20624062
160Choline metabolism in cancer_Homo sapiens_hsa052310.20113313
161Nitrogen metabolism_Homo sapiens_hsa009100.19931631
162Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18569933
163Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18356148
164Tryptophan metabolism_Homo sapiens_hsa003800.17481623
165Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16168521
166Adherens junction_Homo sapiens_hsa045200.15748205
167Arginine and proline metabolism_Homo sapiens_hsa003300.15694799
168Fatty acid biosynthesis_Homo sapiens_hsa000610.15501275
169Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13894846
170Mineral absorption_Homo sapiens_hsa049780.13013614

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