VWF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1blood vessel maturation (GO:0001955)6.96746147
2surfactant homeostasis (GO:0043129)6.07129564
3regulation of endothelial cell differentiation (GO:0045601)5.65734966
4endothelial tube morphogenesis (GO:0061154)5.62423583
5morphogenesis of an endothelium (GO:0003159)5.62423583
6vascular endothelial growth factor signaling pathway (GO:0038084)5.50327332
7lymph vessel development (GO:0001945)5.47910482
8cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.78313162
9ovulation from ovarian follicle (GO:0001542)4.71172370
10chemical homeostasis within a tissue (GO:0048875)4.64137712
11positive regulation of vasculogenesis (GO:2001214)4.59734127
12endothelium development (GO:0003158)4.51122787
13definitive hemopoiesis (GO:0060216)4.49072963
14regulation of vasculogenesis (GO:2001212)4.40308314
15retina vasculature morphogenesis in camera-type eye (GO:0061299)4.38116963
16lymphangiogenesis (GO:0001946)4.19696675
17positive regulation of endothelial cell differentiation (GO:0045603)4.08298276
18endothelial cell morphogenesis (GO:0001886)3.83181912
19glomerular filtration (GO:0003094)3.78825943
20renal filtration (GO:0097205)3.63763693
21negative regulation of focal adhesion assembly (GO:0051895)3.63332289
22negative regulation of cell junction assembly (GO:1901889)3.63332289
23negative regulation of adherens junction organization (GO:1903392)3.63332289
24phagocytosis, recognition (GO:0006910)3.61700076
25venous blood vessel morphogenesis (GO:0048845)3.59265477
26positive regulation of receptor recycling (GO:0001921)3.48046449
27patterning of blood vessels (GO:0001569)3.45483760
28regulation of integrin activation (GO:0033623)3.43459023
29ganglion development (GO:0061548)3.41690973
30wound healing, spreading of epidermal cells (GO:0035313)3.39456239
31protein kinase C signaling (GO:0070528)3.38858418
32negative regulation of nitric-oxide synthase activity (GO:0051001)3.37472568
33endothelial cell differentiation (GO:0045446)3.35595582
34blood vessel remodeling (GO:0001974)3.35488722
35regulation of cellular extravasation (GO:0002691)3.31260744
36vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.28509060
37regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.26928935
38positive regulation of urine volume (GO:0035810)3.24003486
39negative regulation of stress fiber assembly (GO:0051497)3.23922430
40nephron epithelium development (GO:0072009)3.17152720
41neuron remodeling (GO:0016322)3.10158765
42angiogenesis involved in wound healing (GO:0060055)3.08762039
43positive regulation of glomerulus development (GO:0090193)3.07822526
44substrate-dependent cell migration (GO:0006929)3.06746141
45establishment of endothelial barrier (GO:0061028)3.06221590
46Notch signaling involved in heart development (GO:0061314)3.04771309
47regulation of blood vessel endothelial cell migration (GO:0043535)3.03214986
48negative regulation of platelet activation (GO:0010544)2.97706651
49megakaryocyte development (GO:0035855)2.96368385
50negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.95004399
51negative regulation of DNA biosynthetic process (GO:2000279)2.94973871
52negative regulation of blood vessel endothelial cell migration (GO:0043537)2.94426435
53negative regulation of actin filament bundle assembly (GO:0032232)2.93057567
54ovulation (GO:0030728)2.91716377
55cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.91687963
56negative regulation of endothelial cell apoptotic process (GO:2000352)2.91209848
57regulation of glomerular filtration (GO:0003093)2.88776162
58vasculogenesis (GO:0001570)2.88235818
59positive regulation of p38MAPK cascade (GO:1900745)2.87903930
60cAMP biosynthetic process (GO:0006171)2.84581813
61positive regulation of endothelial cell apoptotic process (GO:2000353)2.84438819
62endocrine hormone secretion (GO:0060986)2.84398805
63cellular response to epinephrine stimulus (GO:0071872)2.84328241
64positive regulation of macrophage cytokine production (GO:0060907)2.84033244
65negative regulation of endothelial cell proliferation (GO:0001937)2.83962165
66axon extension involved in axon guidance (GO:0048846)2.82881984
67neuron projection extension involved in neuron projection guidance (GO:1902284)2.82881984
68negative regulation of endothelial cell migration (GO:0010596)2.80776702
69sprouting angiogenesis (GO:0002040)2.80469073
70metanephric nephron epithelium development (GO:0072243)2.80056766
71regulation of p38MAPK cascade (GO:1900744)2.79830779
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78101935
73ventricular trabecula myocardium morphogenesis (GO:0003222)2.76594777
74positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.75056698
75fibroblast migration (GO:0010761)2.74837020
76peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.73220808
77basement membrane organization (GO:0071711)2.72562466
78apoptotic cell clearance (GO:0043277)2.71780157
79regulation of endothelial cell migration (GO:0010594)2.70766404
80cellular response to nitric oxide (GO:0071732)2.70158186
81cell volume homeostasis (GO:0006884)2.70008505
82response to muramyl dipeptide (GO:0032495)2.69687120
83positive regulation of blood vessel endothelial cell migration (GO:0043536)2.68766308
84cytoskeletal anchoring at plasma membrane (GO:0007016)2.67754251
85negative regulation of fatty acid transport (GO:2000192)2.66148118
86regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.66046436
87endothelial cell chemotaxis (GO:0035767)2.65602558
88heparin metabolic process (GO:0030202)2.65564414
89heparin biosynthetic process (GO:0030210)2.65564414
90response to fluid shear stress (GO:0034405)2.65465749
91actin-myosin filament sliding (GO:0033275)2.65222011
92muscle filament sliding (GO:0030049)2.65222011
93cardiac myofibril assembly (GO:0055003)2.64854755
94adhesion of symbiont to host (GO:0044406)2.64782149
95positive regulation by symbiont of host defense response (GO:0052509)2.64518926
96modulation by symbiont of host defense response (GO:0052031)2.64518926
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64518926
98modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64518926
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.64518926
100modulation by symbiont of host immune response (GO:0052553)2.64518926
101positive regulation of endothelial cell migration (GO:0010595)2.63718300
102extracellular fibril organization (GO:0043206)2.63520467
103heart trabecula formation (GO:0060347)2.62851428
104smooth muscle tissue development (GO:0048745)2.62188082
105positive regulation of gamma-delta T cell activation (GO:0046645)2.61919101
106cell migration involved in heart development (GO:0060973)2.61712997
107negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61368322
108trabecula morphogenesis (GO:0061383)2.60709495
109pinocytosis (GO:0006907)2.60557907
110myofibril assembly (GO:0030239)2.60355583
111secretory granule organization (GO:0033363)2.59902803
112mesodermal cell differentiation (GO:0048333)2.59588586
113cell-substrate junction assembly (GO:0007044)2.59471669
114negative regulation of epithelial cell migration (GO:0010633)2.58853952
115cell proliferation involved in metanephros development (GO:0072203)2.57505989
116wound healing, spreading of cells (GO:0044319)2.57206298
117positive regulation of digestive system process (GO:0060456)2.57036992
118sarcomere organization (GO:0045214)2.56110409
119cell migration involved in sprouting angiogenesis (GO:0002042)2.56017683
120semaphorin-plexin signaling pathway (GO:0071526)2.55695224
121metanephric epithelium development (GO:0072207)2.55027153
122barbed-end actin filament capping (GO:0051016)2.54807621
123regulation of platelet activation (GO:0010543)2.54719682
124blood circulation (GO:0008015)2.54691466
125regulation of establishment or maintenance of cell polarity (GO:0032878)2.54087354
126positive regulation of odontogenesis (GO:0042482)2.53519625
127artery development (GO:0060840)2.52954694
128atrioventricular valve morphogenesis (GO:0003181)2.52806474
129negative regulation of blood vessel morphogenesis (GO:2000181)2.52716161
130insulin-like growth factor receptor signaling pathway (GO:0048009)2.52078953
131angiogenesis (GO:0001525)2.49581981
132dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49283442
133negative regulation of angiogenesis (GO:0016525)2.48237611
134endothelial cell proliferation (GO:0001935)2.47546254
135regulation of urine volume (GO:0035809)2.47543691
136positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47397354
137regulation of gamma-delta T cell activation (GO:0046643)2.46884614
138coronary vasculature morphogenesis (GO:0060977)2.46623629
139response to interferon-alpha (GO:0035455)2.46563802
140embryonic placenta development (GO:0001892)2.45895453
141negative regulation of protein autophosphorylation (GO:0031953)2.45187446
142positive regulation of fibroblast migration (GO:0010763)2.44852293
143low-density lipoprotein particle clearance (GO:0034383)2.44790501
144positive regulation of adherens junction organization (GO:1903393)2.44713460
145daunorubicin metabolic process (GO:0044597)2.44468400
146polyketide metabolic process (GO:0030638)2.44468400
147doxorubicin metabolic process (GO:0044598)2.44468400
148cGMP-mediated signaling (GO:0019934)2.42419281
149regulation of macrophage chemotaxis (GO:0010758)2.41218454
150embryonic heart tube development (GO:0035050)2.41164271
151negative regulation of vasculature development (GO:1901343)2.40366782
152regulation of sarcomere organization (GO:0060297)2.40227439
153neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.40062834
154response to epinephrine (GO:0071871)2.39127135
155regulation of integrin-mediated signaling pathway (GO:2001044)2.39051138
156positive regulation of endothelial cell proliferation (GO:0001938)2.36280045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.21296009
2* GATA2_21666600_ChIP-Seq_HMVEC_Human4.15032540
3SCL_19346495_ChIP-Seq_HPC-7_Human3.25247086
4GATA1_22025678_ChIP-Seq_K562_Human3.03156373
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.77922126
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.77922126
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.77922126
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.66094841
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.60579883
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.53199837
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.48286837
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23473741
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.14457656
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13859177
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.10871731
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.05214376
17* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.03448888
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97257048
19SPI1_23127762_ChIP-Seq_K562_Human1.90837589
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90395012
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89972921
22* ESR2_21235772_ChIP-Seq_MCF-7_Human1.88752273
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.88275479
24GATA1_19941826_ChIP-Seq_K562_Human1.87903866
25* ESR1_21235772_ChIP-Seq_MCF-7_Human1.85984588
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.82333795
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81569926
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76558096
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68919491
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66463175
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63739036
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63579694
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62632708
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62229210
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62229210
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61419210
37RUNX_20019798_ChIP-Seq_JUKART_Human1.58595207
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53836174
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52747804
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52092739
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51806318
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48881867
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48859420
44NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46582499
45CLOCK_20551151_ChIP-Seq_293T_Human1.45684622
46TCF7_22412390_ChIP-Seq_EML_Mouse1.45106755
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44177666
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43860354
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41398455
50* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41176121
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.40951507
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39998894
53* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39577215
54DROSHA_22980978_ChIP-Seq_HELA_Human1.37404344
55* CDX2_20551321_ChIP-Seq_CACO-2_Human1.36258127
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33118600
57* TBX20_22080862_ChIP-Seq_HEART_Mouse1.32644907
58* TBX20_22328084_ChIP-Seq_HEART_Mouse1.32644907
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32618425
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31789821
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30572057
62* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29190891
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.29049966
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28482295
65* GATA1_19941827_ChIP-Seq_MEL_Mouse1.25732383
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25092516
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23873735
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23315691
69* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22889014
70GATA2_19941826_ChIP-Seq_K562_Human1.22828324
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20213429
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20161414
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19706571
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.19108840
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14613347
76* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14027141
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13715711
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12813279
79CJUN_26792858_Chip-Seq_BT549_Human1.12693370
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12253044
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10234698
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09713661
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08936234
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08784216
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.08442887
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.08219233
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08195850
88LXR_22292898_ChIP-Seq_THP-1_Human1.07839097
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06964208
90KDM2B_26808549_Chip-Seq_K562_Human1.06853194
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05840943
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04003995
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.03386793
94AHR_22903824_ChIP-Seq_MCF-7_Human1.02659596
95VDR_24787735_ChIP-Seq_THP-1_Human1.02537537
96FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02373842
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01537085
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.00557611
99TP53_23651856_ChIP-Seq_MEFs_Mouse1.00198252
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99648722
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98991057
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98950692
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98717404
104STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98509765
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98408951
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98048375
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95483252
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94803126
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94803126
110EGR1_19374776_ChIP-ChIP_THP-1_Human0.94749463
111NCOR1_26117541_ChIP-Seq_K562_Human0.94647174
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94328024
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93822865
114NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92494814
115KDM2B_26808549_Chip-Seq_DND41_Human0.92447290
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91926041
117SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91750661
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90793408
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90643276
120SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90252530
121EZH2_22144423_ChIP-Seq_EOC_Human0.90215467
122SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89823215
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89253874
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88849197
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88516225
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88374100
127P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87825604
128RXR_22158963_ChIP-Seq_LIVER_Mouse0.87580203
129SOX2_20726797_ChIP-Seq_SW620_Human0.87535943
130ISL1_27105846_Chip-Seq_CPCs_Mouse0.87366770
131MAF_26560356_Chip-Seq_TH1_Human0.87204797
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86553347
133VDR_24763502_ChIP-Seq_THP-1_Human0.86148486
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84184014
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83832610
136BRD4_25478319_ChIP-Seq_HGPS_Human0.83617010
137TCF4_18268006_ChIP-ChIP_LS174T_Human0.83339747
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83230564
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83230564
140BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81840580
141NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81811806
142TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81610578
143RACK7_27058665_Chip-Seq_MCF-7_Human0.81583468
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.80665720
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.79717296
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.79700313
147EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78664532
148EZH2_27304074_Chip-Seq_ESCs_Mouse0.78495527
149PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77993150
150SUZ12_27294783_Chip-Seq_ESCs_Mouse0.77958451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.73310002
2MP0001879_abnormal_lymphatic_vessel4.83415924
3* MP0005167_abnormal_blood-brain_barrier4.66060290
4MP0003724_increased_susceptibility_to3.73589092
5MP0003828_pulmonary_edema3.72895116
6MP0004272_abnormal_basement_membrane3.19523064
7MP0004084_abnormal_cardiac_muscle3.17507857
8MP0009278_abnormal_bone_marrow2.79940307
9MP0008438_abnormal_cutaneous_collagen2.64945384
10MP0001958_emphysema2.62883717
11MP0004510_myositis2.59789347
12MP0004782_abnormal_surfactant_physiolog2.57178459
13MP0000767_abnormal_smooth_muscle2.36050977
14MP0004145_abnormal_muscle_electrophysio2.20547259
15MP0005275_abnormal_skin_tensile2.14729745
16MP0003566_abnormal_cell_adhesion2.12418565
17MP0002138_abnormal_hepatobiliary_system2.09672069
18MP0000465_gastrointestinal_hemorrhage2.04009962
19MP0002332_abnormal_exercise_endurance1.89706185
20MP0005409_darkened_coat_color1.80363179
21MP0004036_abnormal_muscle_relaxation1.79605192
22MP0006138_congestive_heart_failure1.78512641
23MP0005397_hematopoietic_system_phenotyp1.72339770
24MP0001545_abnormal_hematopoietic_system1.72339770
25MP0009780_abnormal_chondrocyte_physiolo1.70607304
26MP0002933_joint_inflammation1.70489155
27MP0003279_aneurysm1.69903959
28MP0000013_abnormal_adipose_tissue1.68502293
29MP0008775_abnormal_heart_ventricle1.65051562
30* MP0000249_abnormal_blood_vessel1.63991234
31MP0005666_abnormal_adipose_tissue1.62114867
32MP0003303_peritoneal_inflammation1.59997739
33MP0003191_abnormal_cellular_cholesterol1.59504438
34* MP0000343_altered_response_to1.58873594
35MP0002108_abnormal_muscle_morphology1.52517092
36MP0000569_abnormal_digit_pigmentation1.49794689
37MP0005375_adipose_tissue_phenotype1.47724606
38MP0005620_abnormal_muscle_contractility1.44265545
39MP0001851_eye_inflammation1.42098882
40MP0005385_cardiovascular_system_phenoty1.39547137
41MP0001544_abnormal_cardiovascular_syste1.39547137
42MP0005165_increased_susceptibility_to1.38652962
43MP0001835_abnormal_antigen_presentation1.36580053
44MP0002925_abnormal_cardiovascular_devel1.36201616
45MP0004808_abnormal_hematopoietic_stem1.35179623
46MP0010030_abnormal_orbit_morphology1.33772055
47MP0005503_abnormal_tendon_morphology1.31477346
48MP0003448_altered_tumor_morphology1.28932069
49MP0004484_altered_response_of1.28205272
50MP0002127_abnormal_cardiovascular_syste1.28013329
51MP0003705_abnormal_hypodermis_morpholog1.27066617
52* MP0005464_abnormal_platelet_physiology1.25815232
53MP0000003_abnormal_adipose_tissue1.23429975
54MP0009697_abnormal_copulation1.22998451
55* MP0002128_abnormal_blood_circulation1.22969980
56MP0000759_abnormal_skeletal_muscle1.22324924
57MP0010630_abnormal_cardiac_muscle1.22229826
58MP0004233_abnormal_muscle_weight1.22214683
59MP0004883_abnormal_blood_vessel1.21863844
60MP0001614_abnormal_blood_vessel1.21641576
61MP0003091_abnormal_cell_migration1.20082410
62MP0005595_abnormal_vascular_smooth1.15343476
63MP0005330_cardiomyopathy1.15258970
64MP0002254_reproductive_system_inflammat1.15248742
65MP0005164_abnormal_response_to1.15128751
66MP0004147_increased_porphyrin_level1.12887108
67MP0002133_abnormal_respiratory_system1.12406014
68MP0005388_respiratory_system_phenotype1.12406014
69MP0009785_altered_susceptibility_to1.10806029
70MP0004215_abnormal_myocardial_fiber1.09980180
71MP0000751_myopathy1.09930370
72MP0005075_abnormal_melanosome_morpholog1.09021100
73MP0003950_abnormal_plasma_membrane1.08057013
74MP0005369_muscle_phenotype1.07784657
75MP0002971_abnormal_brown_adipose1.07101498
76MP0004085_abnormal_heartbeat1.06095464
77MP0002396_abnormal_hematopoietic_system1.05722932
78MP0003300_gastrointestinal_ulcer1.03724185
79MP0002419_abnormal_innate_immunity1.01461819
80MP0003045_fibrosis1.00515517
81* MP0005025_abnormal_response_to0.98153234
82MP0002972_abnormal_cardiac_muscle0.97546965
83MP0002277_abnormal_respiratory_mucosa0.96255483
84MP0010352_gastrointestinal_tract_polyps0.95310175
85MP0000747_muscle_weakness0.94559602
86MP0000750_abnormal_muscle_regeneration0.93242669
87MP0009115_abnormal_fat_cell0.91647833
88MP0009764_decreased_sensitivity_to0.91148650
89MP0002295_abnormal_pulmonary_circulatio0.88857220
90MP0000266_abnormal_heart_morphology0.88594165
91MP0005174_abnormal_tail_pigmentation0.88530637
92MP0005623_abnormal_meninges_morphology0.86976207
93MP0001175_abnormal_lung_morphology0.86909136
94MP0006054_spinal_hemorrhage0.86451503
95MP0003690_abnormal_glial_cell0.85938886
96MP0000749_muscle_degeneration0.85658319
97MP0001849_ear_inflammation0.85385964
98MP0010155_abnormal_intestine_physiology0.84696207
99MP0002132_abnormal_respiratory_system0.84333096
100MP0002896_abnormal_bone_mineralization0.83365495
101MP0002877_abnormal_melanocyte_morpholog0.83229522
102MP0004130_abnormal_muscle_cell0.83177783
103MP0002405_respiratory_system_inflammati0.80449803
104MP0002166_altered_tumor_susceptibility0.79930206
105MP0005387_immune_system_phenotype0.79128025
106MP0001790_abnormal_immune_system0.79128025
107MP0002148_abnormal_hypersensitivity_rea0.77550288
108MP0002998_abnormal_bone_remodeling0.77327309
109MP0001661_extended_life_span0.76705536
110MP0002452_abnormal_antigen_presenting0.76560029
111MP0000733_abnormal_muscle_development0.75313129
112MP0005670_abnormal_white_adipose0.73795371
113MP0008995_early_reproductive_senescence0.73436098
114MP0002168_other_aberrant_phenotype0.71909647
115MP0003948_abnormal_gas_homeostasis0.71078410
116MP0002723_abnormal_immune_serum0.70778714
117MP0003646_muscle_fatigue0.70670086
118MP0001915_intracranial_hemorrhage0.70046929
119MP0003941_abnormal_skin_development0.69975123
120MP0003943_abnormal_hepatobiliary_system0.68790862
121MP0008004_abnormal_stomach_pH0.68276965
122MP0005023_abnormal_wound_healing0.68142220
123MP0002269_muscular_atrophy0.68066207
124MP0001819_abnormal_immune_cell0.66976270
125MP0002106_abnormal_muscle_physiology0.66963082
126MP0001853_heart_inflammation0.66912173
127MP0003436_decreased_susceptibility_to0.66811477
128MP0005508_abnormal_skeleton_morphology0.66471006
129MP0001784_abnormal_fluid_regulation0.66236259
130MP0000685_abnormal_immune_system0.66019097
131MP0002420_abnormal_adaptive_immunity0.65772083
132MP0004087_abnormal_muscle_fiber0.64802139
133MP0005671_abnormal_response_to0.63796511
134MP0000230_abnormal_systemic_arterial0.62182398
135MP0003959_abnormal_lean_body0.58834525
136MP0003385_abnormal_body_wall0.58453815
137MP0004858_abnormal_nervous_system0.56657235
138MP0002932_abnormal_joint_morphology0.51789109

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)6.59823631
2Spontaneous hematomas (HP:0007420)6.50109767
3Polycythemia (HP:0001901)6.18616532
4Abnormality of the nasal mucosa (HP:0000433)5.42153790
5Protrusio acetabuli (HP:0003179)5.18891906
6Wrist flexion contracture (HP:0001239)4.52734192
7Esophageal varix (HP:0002040)4.47656587
8Pulmonary artery stenosis (HP:0004415)4.33132878
9Spinal rigidity (HP:0003306)4.03611648
10Conjunctival telangiectasia (HP:0000524)3.73867824
11Interstitial pulmonary disease (HP:0006530)3.64868433
12Portal hypertension (HP:0001409)3.62271444
13Increased connective tissue (HP:0009025)3.49571846
14Myotonia (HP:0002486)3.47916068
15Abnormality of the hepatic vasculature (HP:0006707)3.42914728
16Cerebral aneurysm (HP:0004944)3.30763081
17Abnormality of the vasculature of the conjunctiva (HP:0008054)3.25263973
18Hemangiomatosis (HP:0007461)3.13399674
19Visceral angiomatosis (HP:0100761)3.12955146
20Orchitis (HP:0100796)3.10786661
21Ventricular tachycardia (HP:0004756)3.08517156
22Arterial tortuosity (HP:0005116)3.05129505
23Overgrowth (HP:0001548)3.03284976
24Vascular tortuosity (HP:0004948)3.02936455
25Broad metatarsal (HP:0001783)3.02000134
26Type 1 muscle fiber predominance (HP:0003803)2.92612659
27Atrial fibrillation (HP:0005110)2.91620347
28* Prolonged bleeding time (HP:0003010)2.87966643
29Aortic aneurysm (HP:0004942)2.87414680
30Porencephaly (HP:0002132)2.80017176
31Myositis (HP:0100614)2.79970793
32Supraventricular arrhythmia (HP:0005115)2.77040293
33Difficulty climbing stairs (HP:0003551)2.74051281
34Distal lower limb amyotrophy (HP:0008944)2.73689090
35Aortic dissection (HP:0002647)2.73428113
36Microcytic anemia (HP:0001935)2.71806073
37Difficulty running (HP:0009046)2.70307925
38Pulmonary hypertension (HP:0002092)2.69462184
39Primary atrial arrhythmia (HP:0001692)2.67105570
40Elevated erythrocyte sedimentation rate (HP:0003565)2.65083006
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.62660908
42Bundle branch block (HP:0011710)2.62156419
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.59834653
44Hemoptysis (HP:0002105)2.59097268
45Cerebral hemorrhage (HP:0001342)2.58175325
46Muscle fiber inclusion bodies (HP:0100299)2.57939297
47Hip contracture (HP:0003273)2.56925422
48EMG: myopathic abnormalities (HP:0003458)2.55974858
49Adactyly (HP:0009776)2.54055466
50Eczematoid dermatitis (HP:0000976)2.53490102
51Supraventricular tachycardia (HP:0004755)2.52595585
52Exercise-induced myalgia (HP:0003738)2.52038414
53* Epistaxis (HP:0000421)2.51582306
54Hemorrhage of the eye (HP:0011885)2.49662114
55Aneurysm (HP:0002617)2.49100663
56Neonatal death (HP:0003811)2.48406972
57Premature rupture of membranes (HP:0001788)2.44070180
58Wormian bones (HP:0002645)2.43684785
59Nemaline bodies (HP:0003798)2.38675221
60Recurrent abscess formation (HP:0002722)2.37525451
61Neck muscle weakness (HP:0000467)2.35955367
62Abnormality of the calf musculature (HP:0001430)2.34415894
63Right ventricular cardiomyopathy (HP:0011663)2.33107648
64Ectopia lentis (HP:0001083)2.32376846
65Mildly elevated creatine phosphokinase (HP:0008180)2.31529827
66Venous insufficiency (HP:0005293)2.29264346
67Shallow orbits (HP:0000586)2.28724898
68Venous abnormality (HP:0002624)2.26861057
69Nonimmune hydrops fetalis (HP:0001790)2.23875688
70Lymphangioma (HP:0100764)2.23778292
71Gingival bleeding (HP:0000225)2.23294019
72Muscle fiber splitting (HP:0003555)2.22533904
73Striae distensae (HP:0001065)2.21915563
74Amyloidosis (HP:0011034)2.19081793
75Complement deficiency (HP:0004431)2.18695085
76Pulmonary embolism (HP:0002204)2.18625144
77Tetraparesis (HP:0002273)2.15912600
78Cervical subluxation (HP:0003308)2.15333611
79Distal lower limb muscle weakness (HP:0009053)2.15116175
80Limited hip movement (HP:0008800)2.15029368
81Acanthosis nigricans (HP:0000956)2.14927440
82Absent hand (HP:0004050)2.13377075
83Flexion contracture of toe (HP:0005830)2.11160206
84Joint contractures involving the joints of the feet (HP:0100492)2.11160206
85Dilatation of the ascending aorta (HP:0005111)2.09139258
86Oligomenorrhea (HP:0000876)2.08503266
87Facial diplegia (HP:0001349)2.07667964
88Gingivitis (HP:0000230)2.05174495
89Lower limb amyotrophy (HP:0007210)2.04316240
90Sudden death (HP:0001699)2.03640162
91Stroke (HP:0001297)2.03151099
92Abnormality of complement system (HP:0005339)2.02691042
93Pigmentary retinal degeneration (HP:0001146)2.02393388
94Abnormal platelet volume (HP:0011876)2.02003468
95Vertebral clefting (HP:0008428)1.99319319
96Scapular winging (HP:0003691)1.98942661
97Increased mean platelet volume (HP:0011877)1.97416618
98Mucosal telangiectasiae (HP:0100579)1.97176213
99Recurrent bacterial skin infections (HP:0005406)1.96956585
100Hypoplasia of the iris (HP:0007676)1.95318849
101Reduced subcutaneous adipose tissue (HP:0003758)1.95267914
102Short 4th metacarpal (HP:0010044)1.95116735
103Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95116735
104Atrioventricular block (HP:0001678)1.94203897
105Retrobulbar optic neuritis (HP:0100654)1.93928591
106Optic neuritis (HP:0100653)1.93928591
107Hyporeflexia of lower limbs (HP:0002600)1.93525053
108Recurrent gram-negative bacterial infections (HP:0005420)1.92870231
109Broad face (HP:0000283)1.91978039
110Round ear (HP:0100830)1.91526781
111Dilated cardiomyopathy (HP:0001644)1.90060816
112Abnormal vertebral ossification (HP:0100569)1.89960391
113Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89635743
114Myocardial infarction (HP:0001658)1.88986138
115Bulbar palsy (HP:0001283)1.88065124
116Prostate neoplasm (HP:0100787)1.87124210
117Systemic lupus erythematosus (HP:0002725)1.87053148
118Coxa vara (HP:0002812)1.86232883
119Long toe (HP:0010511)1.85585486
120Autoimmune thrombocytopenia (HP:0001973)1.85521099
121Cellulitis (HP:0100658)1.85067972
122Arterial thrombosis (HP:0004420)1.84798816
123Skull defect (HP:0001362)1.83945802
124Hypertriglyceridemia (HP:0002155)1.83531317
125Cerebral ischemia (HP:0002637)1.82915836
126Chest pain (HP:0100749)1.82106833
127Vertigo (HP:0002321)1.81946725
128Hyperactive renin-angiotensin system (HP:0000841)1.81434129
129Hyperkalemia (HP:0002153)1.81314281
130Abnormality of macrophages (HP:0004311)1.80107457
131Abnormality of liposaccharide metabolism (HP:0010968)1.77957298
132Abnormality of glycosphingolipid metabolism (HP:0004343)1.77957298
133Abnormality of glycolipid metabolism (HP:0010969)1.77957298
134Lipoatrophy (HP:0100578)1.77145269
135Purpura (HP:0000979)1.76825552
136Nasal polyposis (HP:0100582)1.73954784
137Hemiplegia (HP:0002301)1.73405389
138Increased cerebral lipofuscin (HP:0011813)1.73056646
139Testicular atrophy (HP:0000029)1.72710541
140Rectal prolapse (HP:0002035)1.72404390
141Annular pancreas (HP:0001734)1.71662123
142* Menorrhagia (HP:0000132)1.71418263
143Hypochromic microcytic anemia (HP:0004840)1.71028470
144Aplasia cutis congenita (HP:0001057)1.70189207
145Increased variability in muscle fiber diameter (HP:0003557)1.69731878
146Lymphedema (HP:0001004)1.69506486
147Abnormality of skeletal muscle fiber size (HP:0012084)1.68358949
148* Bruising susceptibility (HP:0000978)1.68240959
149Emphysema (HP:0002097)1.65675862
150Asymmetric septal hypertrophy (HP:0001670)1.65666893
151Growth hormone excess (HP:0000845)1.63154594
152Petechiae (HP:0000967)1.61645630
153Cavernous hemangioma (HP:0001048)1.61117958
154Pulmonary infiltrates (HP:0002113)1.60714386
155Abnormality of the pulmonary veins (HP:0011718)1.60152880
156Heart block (HP:0012722)1.58482541
157Abnormal atrioventricular conduction (HP:0005150)1.58230314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.59574107
2KDR3.46704415
3GRK12.89515134
4RIPK12.56199592
5TGFBR12.16740553
6TIE110.6306919
7CDK121.98359866
8ERN11.90951573
9PRKG21.80386983
10TTN1.58137928
11KIT1.54412468
12EEF2K1.44730257
13PTK2B1.23047361
14MAP3K141.21769746
15MATK1.21201518
16MAPKAPK31.17675909
17MYLK1.15118139
18MAPK71.14530475
19TRIB31.13955184
20GRK71.11820706
21NTRK11.11785168
22GRK51.10862234
23PTK61.10009056
24EPHB11.07307249
25DMPK1.03234141
26CSK1.02435900
27MAP2K31.02216683
28CAMK1D1.01730631
29IRAK30.99792709
30PAK40.97881100
31FGFR30.96587590
32IKBKE0.95428104
33STK240.94316215
34EPHB20.94258905
35JAK30.86556542
36TBK10.86253665
37TEC0.85737702
38LATS20.85245671
39CSF1R0.84463113
40CAMK1G0.83365716
41MUSK0.83077121
42RPS6KA20.82261907
43IKBKB0.81900585
44CDC42BPA0.79481596
45MAP4K10.79116777
46MAP3K30.78795655
47TYK20.77938256
48PKN20.76147080
49PRKD20.75448715
50DDR20.72620456
51PRKD10.71997870
52NLK0.69699107
53MAPK120.69672993
54CAMK40.68849357
55ROCK10.68492766
56HCK0.67948779
57ACVR1B0.67834582
58MET0.67348190
59INSRR0.66102704
60STK100.65185821
61EPHA30.63804526
62CHUK0.63173234
63FGFR40.62065037
64PRKCH0.61659153
65JAK10.61155942
66PRKAA20.59884819
67MARK20.58526784
68PTK20.58438736
69PDGFRA0.57906072
70SGK20.57716559
71FES0.57582152
72ADRBK20.57489487
73FER0.56403573
74HIPK20.56189004
75ZAP700.53719439
76ROCK20.53470729
77PHKG20.52398677
78PHKG10.52398677
79PRKD30.51482244
80ICK0.51312005
81TRPM70.50320711
82PDGFRB0.50093447
83IGF1R0.48547789
84MAP3K10.48008375
85MAPK40.47875338
86RET0.47498705
87MAP3K70.47160004
88JAK20.46776202
89PAK20.46560205
90SGK2230.46489768
91SGK4940.46489768
92LRRK20.45424942
93PDPK10.44982641
94EGFR0.44559241
95IRAK40.44385208
96TAOK30.43973276
97SIK20.42483103
98CAMK10.41419118
99PRKAA10.40767348
100MAP3K130.40387746
101PRPF4B0.40257686
102PIK3CA0.39985714
103BTK0.39093485
104DAPK30.38651349
105LATS10.37647101
106PINK10.36682492
107RPS6KL10.35561636
108RPS6KC10.35561636
109GSK3A0.34535449
110MAPK150.34083939
111LMTK20.33942456
112EPHA20.33751072
113LCK0.33681011
114STK30.33568964
115NEK90.32944597
116PDK10.31422223
117TESK10.31168228
118PAK60.30901600
119OBSCN0.29990200
120ABL20.29794764
121WNK10.29764628
122ITK0.29503811
123STK380.29430829
124SGK30.28208510
125SRC0.27894340
126MARK30.27124523
127MAP2K10.26993119
128INSR0.26741917
129PKN10.26334508
130MAP3K60.26032569
131ABL10.25715292
132PIM10.25385636
133CDK80.25272848
134SMG10.25222324
135RPS6KA60.25131134
136CAMK2D0.25068427
137EIF2AK20.23475065
138MTOR0.22964921
139GRK60.22593080
140MOS0.21973526

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051442.30417163
2AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.06651689
3* ECM-receptor interaction_Homo sapiens_hsa045122.00507925
4Leukocyte transendothelial migration_Homo sapiens_hsa046701.93987494
5Notch signaling pathway_Homo sapiens_hsa043301.91441663
6* Platelet activation_Homo sapiens_hsa046111.79625407
7Dorso-ventral axis formation_Homo sapiens_hsa043201.78940791
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78822472
9Dilated cardiomyopathy_Homo sapiens_hsa054141.78425478
10Caffeine metabolism_Homo sapiens_hsa002321.75192665
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68587300
12* Focal adhesion_Homo sapiens_hsa045101.68381640
13Osteoclast differentiation_Homo sapiens_hsa043801.65603589
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.65455414
15Leishmaniasis_Homo sapiens_hsa051401.63656164
16PPAR signaling pathway_Homo sapiens_hsa033201.61002153
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.60461381
18Small cell lung cancer_Homo sapiens_hsa052221.59755339
19Hematopoietic cell lineage_Homo sapiens_hsa046401.45893644
20African trypanosomiasis_Homo sapiens_hsa051431.45791590
21TNF signaling pathway_Homo sapiens_hsa046681.44882643
22Toxoplasmosis_Homo sapiens_hsa051451.42722540
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.34536748
24Staphylococcus aureus infection_Homo sapiens_hsa051501.32564418
25Rap1 signaling pathway_Homo sapiens_hsa040151.31017253
26Ovarian steroidogenesis_Homo sapiens_hsa049131.30111504
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29669451
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29173766
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27713880
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25016977
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24700695
32Measles_Homo sapiens_hsa051621.21223294
33Influenza A_Homo sapiens_hsa051641.20031152
34B cell receptor signaling pathway_Homo sapiens_hsa046621.19336777
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18703922
36Adherens junction_Homo sapiens_hsa045201.17346237
37Amoebiasis_Homo sapiens_hsa051461.16811255
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.16795116
39* Complement and coagulation cascades_Homo sapiens_hsa046101.16172555
40Pertussis_Homo sapiens_hsa051331.15243829
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14392842
42Phenylalanine metabolism_Homo sapiens_hsa003601.13455104
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13139672
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10286589
45Acute myeloid leukemia_Homo sapiens_hsa052211.09614056
46GnRH signaling pathway_Homo sapiens_hsa049121.08827116
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.08724553
48VEGF signaling pathway_Homo sapiens_hsa043701.07224725
49Gap junction_Homo sapiens_hsa045401.06800800
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.05608174
51Apoptosis_Homo sapiens_hsa042101.04817575
52Salmonella infection_Homo sapiens_hsa051321.04298400
53Hepatitis C_Homo sapiens_hsa051601.00989881
54MicroRNAs in cancer_Homo sapiens_hsa052061.00147281
55Other glycan degradation_Homo sapiens_hsa005110.99500805
56Oxytocin signaling pathway_Homo sapiens_hsa049210.98756236
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.98297256
58* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97490012
59Insulin resistance_Homo sapiens_hsa049310.97412172
60Proteoglycans in cancer_Homo sapiens_hsa052050.96785404
61Renin secretion_Homo sapiens_hsa049240.96003750
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95775272
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95408286
64Rheumatoid arthritis_Homo sapiens_hsa053230.94996661
65Viral myocarditis_Homo sapiens_hsa054160.92746919
66Prion diseases_Homo sapiens_hsa050200.92608237
67HIF-1 signaling pathway_Homo sapiens_hsa040660.92394635
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92132071
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89811396
70Pathways in cancer_Homo sapiens_hsa052000.89160463
71Axon guidance_Homo sapiens_hsa043600.88519905
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87649048
73AMPK signaling pathway_Homo sapiens_hsa041520.86433535
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86410189
75TGF-beta signaling pathway_Homo sapiens_hsa043500.86117513
76Arginine biosynthesis_Homo sapiens_hsa002200.85912813
77Gastric acid secretion_Homo sapiens_hsa049710.85888303
78Circadian rhythm_Homo sapiens_hsa047100.85640709
79Chemokine signaling pathway_Homo sapiens_hsa040620.85400003
80Insulin signaling pathway_Homo sapiens_hsa049100.82774265
81Pancreatic cancer_Homo sapiens_hsa052120.79601925
82Chronic myeloid leukemia_Homo sapiens_hsa052200.79015024
83Tuberculosis_Homo sapiens_hsa051520.78601001
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78493009
85Legionellosis_Homo sapiens_hsa051340.78118131
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76790694
87ABC transporters_Homo sapiens_hsa020100.76478295
88Estrogen signaling pathway_Homo sapiens_hsa049150.74471960
89Lysosome_Homo sapiens_hsa041420.74272455
90Histidine metabolism_Homo sapiens_hsa003400.74212951
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73688864
92Ras signaling pathway_Homo sapiens_hsa040140.73462102
93Prolactin signaling pathway_Homo sapiens_hsa049170.73298915
94Circadian entrainment_Homo sapiens_hsa047130.73094149
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.72480983
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71022208
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70531557
98Melanogenesis_Homo sapiens_hsa049160.70251837
99Protein digestion and absorption_Homo sapiens_hsa049740.70003624
100Long-term potentiation_Homo sapiens_hsa047200.69548754
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.69031640
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66210162
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65475388
104Bile secretion_Homo sapiens_hsa049760.65021493
105Herpes simplex infection_Homo sapiens_hsa051680.64375161
106Salivary secretion_Homo sapiens_hsa049700.63636738
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63402422
108Glioma_Homo sapiens_hsa052140.63396606
109Hepatitis B_Homo sapiens_hsa051610.62978867
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61712204
111Renal cell carcinoma_Homo sapiens_hsa052110.59443979
112Fatty acid degradation_Homo sapiens_hsa000710.59220442
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58690072
114Sphingolipid metabolism_Homo sapiens_hsa006000.58433541
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58113122
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56464030
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56322911
118Shigellosis_Homo sapiens_hsa051310.55920199
119MAPK signaling pathway_Homo sapiens_hsa040100.55867767
120HTLV-I infection_Homo sapiens_hsa051660.55778013
121cAMP signaling pathway_Homo sapiens_hsa040240.54656213
122Taste transduction_Homo sapiens_hsa047420.54260824
123Pancreatic secretion_Homo sapiens_hsa049720.54236488
124Choline metabolism in cancer_Homo sapiens_hsa052310.53998787
125Glycerolipid metabolism_Homo sapiens_hsa005610.53679804
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53480457
127Morphine addiction_Homo sapiens_hsa050320.52917568
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52483250
129Calcium signaling pathway_Homo sapiens_hsa040200.52359434
130Glutamatergic synapse_Homo sapiens_hsa047240.52027525
131Tyrosine metabolism_Homo sapiens_hsa003500.51959256
132Phagosome_Homo sapiens_hsa041450.51745994
133Glucagon signaling pathway_Homo sapiens_hsa049220.50961371
134Arachidonic acid metabolism_Homo sapiens_hsa005900.50489816
135Endocytosis_Homo sapiens_hsa041440.50402968
136Arginine and proline metabolism_Homo sapiens_hsa003300.49794810
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49679290
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49067754
139Tight junction_Homo sapiens_hsa045300.48904401
140Serotonergic synapse_Homo sapiens_hsa047260.48392728
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.47332059
142Bladder cancer_Homo sapiens_hsa052190.46346682
143Basal cell carcinoma_Homo sapiens_hsa052170.44364454
144Long-term depression_Homo sapiens_hsa047300.44279848
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.43132296

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