WAC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.89413289
2histone H3-K36 demethylation (GO:0070544)4.64783180
3neuron cell-cell adhesion (GO:0007158)4.33500772
4histone H3-K9 demethylation (GO:0033169)4.29200058
5monoubiquitinated protein deubiquitination (GO:0035520)4.26718256
6nuclear pore organization (GO:0006999)4.26398473
7presynaptic membrane assembly (GO:0097105)4.12373266
8negative regulation of histone methylation (GO:0031061)3.85214616
9dendritic spine morphogenesis (GO:0060997)3.68842813
10histone lysine demethylation (GO:0070076)3.62724861
11presynaptic membrane organization (GO:0097090)3.57950563
12histone H3-K9 modification (GO:0061647)3.57492493
13central nervous system myelination (GO:0022010)3.54107805
14axon ensheathment in central nervous system (GO:0032291)3.54107805
15limb bud formation (GO:0060174)3.49720426
16histone demethylation (GO:0016577)3.49338823
17histone H3-K4 methylation (GO:0051568)3.42930662
18peptidyl-lysine trimethylation (GO:0018023)3.42136325
19positive regulation of gamma-delta T cell activation (GO:0046645)3.38365271
20regulation of histone H3-K9 methylation (GO:0051570)3.34090316
21phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.33677774
22neuron recognition (GO:0008038)3.33601732
23pore complex assembly (GO:0046931)3.32785278
24histone H4-K16 acetylation (GO:0043984)3.30658397
25regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29122878
26histone H3-K9 methylation (GO:0051567)3.27591796
27sister chromatid cohesion (GO:0007062)3.23889647
28poly(A)+ mRNA export from nucleus (GO:0016973)3.23627529
29positive regulation of granulocyte differentiation (GO:0030854)3.21657227
30regulation of DNA endoreduplication (GO:0032875)3.19576908
31negative regulation of erythrocyte differentiation (GO:0045647)3.19468942
32negative regulation of neurotransmitter secretion (GO:0046929)3.16473009
33peptidyl-threonine phosphorylation (GO:0018107)3.15228280
34regulation of histone H3-K27 methylation (GO:0061085)3.14042724
35negative regulation of neurotransmitter transport (GO:0051589)3.12835692
36N-terminal protein amino acid acetylation (GO:0006474)3.12523364
37positive regulation of Rap GTPase activity (GO:0032854)3.10704862
38negative regulation of DNA repair (GO:0045738)3.05124286
39axonal fasciculation (GO:0007413)3.04899661
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.03173910
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.02364423
42cerebral cortex radially oriented cell migration (GO:0021799)3.02146859
43regulation of histone methylation (GO:0031060)3.00761678
44regulation of NFAT protein import into nucleus (GO:0051532)3.00027557
45pre-miRNA processing (GO:0031054)2.95134494
46regulation of Rap GTPase activity (GO:0032317)2.93676172
47glutamate receptor signaling pathway (GO:0007215)2.92228889
48protein dealkylation (GO:0008214)2.91590552
49protein demethylation (GO:0006482)2.91590552
50peptidyl-threonine modification (GO:0018210)2.90339852
51layer formation in cerebral cortex (GO:0021819)2.89372252
52chondrocyte development (GO:0002063)2.88770936
53regulation of ARF protein signal transduction (GO:0032012)2.86646184
54mRNA splice site selection (GO:0006376)2.85326080
55histone lysine methylation (GO:0034968)2.85275629
56DNA synthesis involved in DNA repair (GO:0000731)2.84548577
57vocalization behavior (GO:0071625)2.84266035
58interkinetic nuclear migration (GO:0022027)2.84042039
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.83873812
60negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81051741
61negative regulation of cell killing (GO:0031342)2.81051741
62positive regulation of synapse assembly (GO:0051965)2.80989854
63regulation of histone H3-K4 methylation (GO:0051569)2.80976007
64cytoplasmic mRNA processing body assembly (GO:0033962)2.79014657
65positive regulation of gene expression, epigenetic (GO:0045815)2.78903683
66negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.78593632
67mitotic chromosome condensation (GO:0007076)2.74723079
68definitive hemopoiesis (GO:0060216)2.74490777
69regulation of dendritic spine morphogenesis (GO:0061001)2.73720262
70transmission of nerve impulse (GO:0019226)2.72639045
71glucocorticoid receptor signaling pathway (GO:0042921)2.72304067
72positive regulation by host of viral transcription (GO:0043923)2.71443888
73regulation of B cell receptor signaling pathway (GO:0050855)2.71427702
74dosage compensation (GO:0007549)2.69365001
75regulation of DNA methylation (GO:0044030)2.68589450
76peptidyl-lysine methylation (GO:0018022)2.67566041
77neuron remodeling (GO:0016322)2.67239311
78asymmetric protein localization (GO:0008105)2.67202282
79regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.64104884
80cerebellar granule cell differentiation (GO:0021707)2.64031089
81activated T cell proliferation (GO:0050798)2.63699901
82histone H3-K4 trimethylation (GO:0080182)2.62070213
83negative regulation of histone modification (GO:0031057)2.59882871
84lateral sprouting from an epithelium (GO:0060601)2.58518290
85protein localization to synapse (GO:0035418)2.57833777
86regulation of RNA export from nucleus (GO:0046831)2.57660338
87central nervous system projection neuron axonogenesis (GO:0021952)2.57506569
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.56070437
89alternative mRNA splicing, via spliceosome (GO:0000380)2.55615156
90embryonic camera-type eye morphogenesis (GO:0048596)2.54025167
91positive T cell selection (GO:0043368)2.50479933
92B cell receptor signaling pathway (GO:0050853)2.49083553
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.48164258
94negative thymic T cell selection (GO:0045060)2.47117535
95regulation of gamma-delta T cell differentiation (GO:0045586)2.45555781
96negative T cell selection (GO:0043383)2.44714144
97negative regulation of chromatin modification (GO:1903309)2.43018019
98regulation of gamma-delta T cell activation (GO:0046643)2.42905185
99nucleus organization (GO:0006997)2.42381982
100positive regulation of meiosis (GO:0045836)2.42169847
101dendrite morphogenesis (GO:0048813)2.41721807
102corticosteroid receptor signaling pathway (GO:0031958)2.41514628
103regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.40664712
104positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.40664712
105regulation of chromatin silencing (GO:0031935)2.40621674
106mating behavior (GO:0007617)2.40560935
107negative regulation of smooth muscle cell differentiation (GO:0051151)2.40304613
108positive regulation of meiotic cell cycle (GO:0051446)2.39987466
109positive regulation of dendritic spine morphogenesis (GO:0061003)2.39473793
110nerve growth factor signaling pathway (GO:0038180)2.39361345
111regulation of glutamate receptor signaling pathway (GO:1900449)2.38445169
112stress granule assembly (GO:0034063)2.38349166
113negative regulation of dendrite morphogenesis (GO:0050774)2.37684360
114L-amino acid import (GO:0043092)2.37620976
115retina layer formation (GO:0010842)2.37582583
116regulation of nucleobase-containing compound transport (GO:0032239)2.37033271
117synapse assembly (GO:0007416)2.36017206
118regulation of mRNA 3-end processing (GO:0031440)2.33959528
119apical protein localization (GO:0045176)2.33320055
120regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.32399470
121positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.32399470
122phosphatidylinositol phosphorylation (GO:0046854)2.32355872
123regulation of dendritic spine development (GO:0060998)2.31502328
124response to muramyl dipeptide (GO:0032495)2.31432741
125regulation of respiratory system process (GO:0044065)2.31019428
126macrophage activation involved in immune response (GO:0002281)2.30825220
127appendage development (GO:0048736)2.30022078
128limb development (GO:0060173)2.30022078
129mitotic sister chromatid cohesion (GO:0007064)2.29234378
130regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.29137374
131dendrite development (GO:0016358)2.29098984
132positive regulation of neurological system process (GO:0031646)2.28282551
133regulation of synapse assembly (GO:0051963)2.28207895
134cerebellar Purkinje cell differentiation (GO:0021702)2.27354265
135positive regulation of cellular response to oxidative stress (GO:1900409)2.27240318
136positive regulation of response to oxidative stress (GO:1902884)2.27240318
137negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.26865234
138negative regulation of translation, ncRNA-mediated (GO:0040033)2.26865234
139regulation of translation, ncRNA-mediated (GO:0045974)2.26865234
140response to interleukin-15 (GO:0070672)2.26693317
141forebrain neuron differentiation (GO:0021879)2.26562780
142regulation of mRNA splicing, via spliceosome (GO:0048024)2.26194031
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.25495066
144postsynaptic membrane organization (GO:0001941)2.25410651
145cell differentiation in hindbrain (GO:0021533)2.24946416
146parental behavior (GO:0060746)2.24831876
147positive regulation of histone H3-K4 methylation (GO:0051571)2.24312659
148histone deubiquitination (GO:0016578)2.23872545
149histone H4 acetylation (GO:0043967)2.23515074
150regulation of chromatin binding (GO:0035561)2.23171643
151positive regulation of histone methylation (GO:0031062)2.21817089
152central nervous system neuron axonogenesis (GO:0021955)2.21319742
153antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.21257045
154positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.20431411
155cochlea development (GO:0090102)2.20086375
156regulation of mRNA processing (GO:0050684)2.19328637
157regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.19204930
158regulation of respiratory gaseous exchange (GO:0043576)2.19204179
159exploration behavior (GO:0035640)2.18348168
160keratinocyte development (GO:0003334)2.18212718
161mRNA stabilization (GO:0048255)2.17912528
162RNA stabilization (GO:0043489)2.17912528
163SMAD protein complex assembly (GO:0007183)2.17651205
164negative regulation of axon extension (GO:0030517)2.17176165
165histone methylation (GO:0016571)2.17057539
166synaptic vesicle exocytosis (GO:0016079)2.16933865
167maternal behavior (GO:0042711)2.16607771
168positive regulation of mRNA processing (GO:0050685)2.16545906
169startle response (GO:0001964)2.16495230
170G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.16444212
171spermatid nucleus differentiation (GO:0007289)2.15766987
172regulation of meiosis I (GO:0060631)2.15628247
173long-term synaptic potentiation (GO:0060291)2.15549869
174regulation of granulocyte differentiation (GO:0030852)2.15448401
175energy homeostasis (GO:0097009)2.15314992
176negative regulation of inclusion body assembly (GO:0090084)2.15181483
177eye photoreceptor cell differentiation (GO:0001754)2.14267984
178photoreceptor cell differentiation (GO:0046530)2.14267984
179synaptic transmission, glutamatergic (GO:0035249)2.13397677
180myelination (GO:0042552)2.13138460
181positive regulation of action potential (GO:0045760)2.12887105
182positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.12724419
183negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.11549275
184neuron maturation (GO:0042551)2.10860958
185locomotory exploration behavior (GO:0035641)2.09400865
186axon ensheathment (GO:0008366)2.09249862
187ensheathment of neurons (GO:0007272)2.09249862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.71595037
2EZH2_22144423_ChIP-Seq_EOC_Human3.22515081
3E2F7_22180533_ChIP-Seq_HELA_Human3.18141961
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.09798332
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.94717904
6GBX2_23144817_ChIP-Seq_PC3_Human2.83995841
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72715375
8TAF15_26573619_Chip-Seq_HEK293_Human2.64018247
9* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.57448441
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51661228
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49173940
12MYC_22102868_ChIP-Seq_BL_Human2.45545696
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.42246813
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38717013
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37806730
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.34994825
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24322548
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.23915638
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23727782
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.23572539
21FUS_26573619_Chip-Seq_HEK293_Human2.21187065
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15969696
23RUNX_20019798_ChIP-Seq_JUKART_Human2.07819032
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03291155
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03291155
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99995487
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98515650
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98246693
29TCF7_22412390_ChIP-Seq_EML_Mouse1.98192821
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.98056138
31DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.97701943
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94891359
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93071542
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93071542
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93071542
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.92342224
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90672152
38P300_19829295_ChIP-Seq_ESCs_Human1.90578681
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88890685
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87804802
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85376266
42AR_21572438_ChIP-Seq_LNCaP_Human1.83834199
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81670084
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81331708
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.79971680
46EWS_26573619_Chip-Seq_HEK293_Human1.79838421
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.79338273
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78389008
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78089705
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77389761
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76801893
52RNF2_27304074_Chip-Seq_NSC_Mouse1.76669521
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.76540478
54VDR_22108803_ChIP-Seq_LS180_Human1.75934130
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74858884
56SCL_19346495_ChIP-Seq_HPC-7_Human1.71749020
57* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71511975
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.70527725
59MYB_26560356_Chip-Seq_TH2_Human1.70002644
60SMAD4_21799915_ChIP-Seq_A2780_Human1.68763581
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68601572
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.67345366
63* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65549269
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62790922
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62600414
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60721654
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.58632580
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57735537
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54058884
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51989637
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51613318
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50540464
73TP53_16413492_ChIP-PET_HCT116_Human1.49026649
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47505463
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47468447
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47234335
77MYB_26560356_Chip-Seq_TH1_Human1.46979473
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46395293
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45675858
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44845842
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43089554
82ER_23166858_ChIP-Seq_MCF-7_Human1.43061825
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41200911
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41166719
85* KDM2B_26808549_Chip-Seq_DND41_Human1.39810741
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.39056391
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.37229458
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.36977859
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36439974
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36439974
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36249915
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34556800
93TP53_18474530_ChIP-ChIP_U2OS_Human1.34031264
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33961681
95E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32639929
96EZH2_27294783_Chip-Seq_ESCs_Mouse1.32466626
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32192128
98BCAT_22108803_ChIP-Seq_LS180_Human1.32175617
99AHR_22903824_ChIP-Seq_MCF-7_Human1.30848205
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30560141
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30331915
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29596308
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.28996375
104* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28744603
105RARB_27405468_Chip-Seq_BRAIN_Mouse1.26567561
106IRF8_27001747_Chip-Seq_BMDM_Mouse1.24881315
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24713861
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24489770
109STAT3_23295773_ChIP-Seq_U87_Human1.23765495
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23436723
111AR_25329375_ChIP-Seq_VCAP_Human1.23184024
112ZNF274_21170338_ChIP-Seq_K562_Hela1.21720387
113RUNX2_22187159_ChIP-Seq_PCA_Human1.21696038
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21236544
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19538062
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18775775
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17844464
118* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17721037
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.17716426
120TP63_19390658_ChIP-ChIP_HaCaT_Human1.17193507
121REST_21632747_ChIP-Seq_MESCs_Mouse1.16900452
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16203903
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16133861
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16033865
125TCF4_23295773_ChIP-Seq_U87_Human1.15294070
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14675935
127KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13631878
128* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13513972
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.10419925
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09738023
131* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09455830
132NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09328979
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08903664
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06792685
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06370551
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05949593
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05172674
138YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04605466
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04394272
140SOX9_26525672_Chip-Seq_HEART_Mouse1.04087382
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03904941
142GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03768513
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03344270
144VDR_24763502_ChIP-Seq_THP-1_Human1.02621064
145RING1B_27294783_Chip-Seq_ESCs_Mouse1.02603700
146* CHD1_26751641_Chip-Seq_LNCaP_Human1.02242327
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01823921
148MAF_26560356_Chip-Seq_TH1_Human1.01254887
149VDR_24787735_ChIP-Seq_THP-1_Human0.99220951
150* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98480809
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98217658
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94638353
153CIITA_25753668_ChIP-Seq_RAJI_Human0.94507907
154TCF4_18268006_ChIP-ChIP_LS174T_Human0.94468542
155PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93585369
156E2F1_21310950_ChIP-Seq_MCF-7_Human0.92383947
157GATA3_27048872_Chip-Seq_THYMUS_Human0.92192090
158RUNX1_22412390_ChIP-Seq_EML_Mouse0.91478630
159* KDM2B_26808549_Chip-Seq_K562_Human0.90754357
160FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90197501
161SPI1_23127762_ChIP-Seq_K562_Human0.88852043
162PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88078383
163* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88052378
164TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87984896
165Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87433928
166CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86960802
167PU_27001747_Chip-Seq_BMDM_Mouse0.85905421
168ISL1_27105846_Chip-Seq_CPCs_Mouse0.82820965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.92441537
2MP0002396_abnormal_hematopoietic_system2.69347654
3MP0005076_abnormal_cell_differentiation2.58279986
4MP0002166_altered_tumor_susceptibility2.42190250
5MP0000778_abnormal_nervous_system2.41388375
6MP0004885_abnormal_endolymph2.39585761
7MP0004270_analgesia2.35731304
8MP0004859_abnormal_synaptic_plasticity2.28540585
9MP0003635_abnormal_synaptic_transmissio2.23708964
10MP0003122_maternal_imprinting2.22772603
11MP0002009_preneoplasia2.14485514
12MP0010352_gastrointestinal_tract_polyps2.05988426
13MP0004808_abnormal_hematopoietic_stem2.00608449
14MP0003763_abnormal_thymus_physiology1.98863108
15MP0003787_abnormal_imprinting1.89850573
16MP0004742_abnormal_vestibular_system1.83532005
17MP0005423_abnormal_somatic_nervous1.83364489
18MP0001529_abnormal_vocalization1.78553994
19MP0002063_abnormal_learning/memory/cond1.78331268
20MP0002064_seizures1.75272349
21MP0003303_peritoneal_inflammation1.74499408
22MP0000703_abnormal_thymus_morphology1.72973080
23MP0009745_abnormal_behavioral_response1.72417791
24MP0003121_genomic_imprinting1.71098016
25MP0001486_abnormal_startle_reflex1.69189515
26MP0002163_abnormal_gland_morphology1.66391275
27MP0002006_tumorigenesis1.64956066
28MP0008057_abnormal_DNA_replication1.64651569
29MP0001348_abnormal_lacrimal_gland1.61213441
30MP0005171_absent_coat_pigmentation1.60581626
31MP0002572_abnormal_emotion/affect_behav1.59715747
32MP0001346_abnormal_lacrimal_gland1.58242435
33MP0001984_abnormal_olfaction1.57955947
34MP0003136_yellow_coat_color1.56347662
35MP0005409_darkened_coat_color1.55309512
36MP0003938_abnormal_ear_development1.54869166
37MP0003300_gastrointestinal_ulcer1.54527606
38MP0002272_abnormal_nervous_system1.53356585
39MP0001485_abnormal_pinna_reflex1.52050385
40MP0000920_abnormal_myelination1.50960048
41MP0002398_abnormal_bone_marrow1.50682561
42MP0010307_abnormal_tumor_latency1.49579362
43MP0001188_hyperpigmentation1.47735485
44MP0002184_abnormal_innervation1.43475413
45MP0001440_abnormal_grooming_behavior1.43405336
46MP0002734_abnormal_mechanical_nocicepti1.40736043
47MP0008961_abnormal_basal_metabolism1.39824626
48MP0001501_abnormal_sleep_pattern1.38575505
49MP0004185_abnormal_adipocyte_glucose1.38546684
50MP0009250_abnormal_appendicular_skeleto1.36967536
51MP0000631_abnormal_neuroendocrine_gland1.35237994
52MP0001968_abnormal_touch/_nociception1.34149920
53MP0003755_abnormal_palate_morphology1.33802334
54MP0006292_abnormal_olfactory_placode1.33088683
55MP0006276_abnormal_autonomic_nervous1.31100482
56MP0001800_abnormal_humoral_immune1.30999356
57MP0008789_abnormal_olfactory_epithelium1.29670319
58MP0000350_abnormal_cell_proliferation1.29438421
59MP0003937_abnormal_limbs/digits/tail_de1.28643566
60MP0009046_muscle_twitch1.26806341
61MP0003385_abnormal_body_wall1.26348480
62MP0002067_abnormal_sensory_capabilities1.25139651
63MP0005379_endocrine/exocrine_gland_phen1.25093427
64MP0005623_abnormal_meninges_morphology1.24995110
65MP0005394_taste/olfaction_phenotype1.23472783
66MP0005499_abnormal_olfactory_system1.23472783
67MP0003828_pulmonary_edema1.21441995
68MP0001340_abnormal_eyelid_morphology1.20881052
69MP0001835_abnormal_antigen_presentation1.20445930
70MP0001879_abnormal_lymphatic_vessel1.19482705
71MP0003690_abnormal_glial_cell1.19209857
72MP0003861_abnormal_nervous_system1.17929512
73MP0006072_abnormal_retinal_apoptosis1.17899299
74MP0010678_abnormal_skin_adnexa1.16748954
75MP0000516_abnormal_urinary_system1.14582741
76MP0005367_renal/urinary_system_phenotyp1.14582741
77MP0002102_abnormal_ear_morphology1.13678662
78MP0002882_abnormal_neuron_morphology1.13162801
79MP0001177_atelectasis1.12798952
80MP0002557_abnormal_social/conspecific_i1.12481060
81MP0005666_abnormal_adipose_tissue1.11683093
82MP0002152_abnormal_brain_morphology1.11663975
83MP0005248_abnormal_Harderian_gland1.11315734
84MP0003077_abnormal_cell_cycle1.11096544
85MP0002282_abnormal_trachea_morphology1.11049436
86MP0000569_abnormal_digit_pigmentation1.10870138
87MP0004264_abnormal_extraembryonic_tissu1.10804204
88MP0003984_embryonic_growth_retardation1.10650874
89MP0001502_abnormal_circadian_rhythm1.08578258
90MP0003890_abnormal_embryonic-extraembry1.08455578
91MP0000955_abnormal_spinal_cord1.07855130
92MP0002088_abnormal_embryonic_growth/wei1.07838055
93MP0002735_abnormal_chemical_nociception1.07204796
94MP0005310_abnormal_salivary_gland1.06387487
95MP0005551_abnormal_eye_electrophysiolog1.05948674
96MP0005380_embryogenesis_phenotype1.05475282
97MP0001672_abnormal_embryogenesis/_devel1.05475282
98MP0000716_abnormal_immune_system1.05137281
99MP0001299_abnormal_eye_distance/1.04146654
100MP0003123_paternal_imprinting1.03587592
101MP0009703_decreased_birth_body1.02991214
102MP0010234_abnormal_vibrissa_follicle1.02698451
103MP0002420_abnormal_adaptive_immunity1.02650675
104MP0002277_abnormal_respiratory_mucosa1.02197767
105MP0004134_abnormal_chest_morphology1.00915549
106MP0002638_abnormal_pupillary_reflex1.00862762
107MP0002722_abnormal_immune_system1.00859012
108MP0001697_abnormal_embryo_size1.00628057
109MP0001730_embryonic_growth_arrest0.99751306
110MP0003111_abnormal_nucleus_morphology0.99245103
111MP0001286_abnormal_eye_development0.99233355
112MP0003943_abnormal_hepatobiliary_system0.99205622
113MP0000537_abnormal_urethra_morphology0.99167801
114MP0000049_abnormal_middle_ear0.99130296
115MP0001819_abnormal_immune_cell0.98353629
116MP0005386_behavior/neurological_phenoty0.97863137
117MP0004924_abnormal_behavior0.97863137
118MP0000689_abnormal_spleen_morphology0.95352154
119MP0000383_abnormal_hair_follicle0.94513618
120MP0000026_abnormal_inner_ear0.94288316
121MP0008569_lethality_at_weaning0.93782347
122MP0001873_stomach_inflammation0.93256848
123MP0002086_abnormal_extraembryonic_tissu0.93073340
124MP0002752_abnormal_somatic_nervous0.93057487
125MP0003935_abnormal_craniofacial_develop0.92661255
126MP0008877_abnormal_DNA_methylation0.92236959
127MP0002736_abnormal_nociception_after0.91430862
128MP0005187_abnormal_penis_morphology0.91375824
129MP0001963_abnormal_hearing_physiology0.89591574
130MP0008995_early_reproductive_senescence0.89394356
131MP0009379_abnormal_foot_pigmentation0.89156146
132MP0002723_abnormal_immune_serum0.88653678
133MP0002751_abnormal_autonomic_nervous0.88485056
134MP0002084_abnormal_developmental_patter0.87972279
135MP0008058_abnormal_DNA_repair0.87938964
136MP0003942_abnormal_urinary_system0.87886254
137MP0001851_eye_inflammation0.87806936
138MP0002938_white_spotting0.87618257
139MP0004381_abnormal_hair_follicle0.87257808
140MP0009115_abnormal_fat_cell0.87225555
141MP0001970_abnormal_pain_threshold0.86425630
142MP0000428_abnormal_craniofacial_morphol0.86236358
143MP0002116_abnormal_craniofacial_bone0.85439251
144MP0001943_abnormal_respiration0.85023059
145MP0004197_abnormal_fetal_growth/weight/0.83871797
146MP0002081_perinatal_lethality0.83525042
147MP0005000_abnormal_immune_tolerance0.82653818
148MP0004947_skin_inflammation0.82631366
149MP0002066_abnormal_motor_capabilities/c0.82076927
150MP0002210_abnormal_sex_determination0.81648357
151MP0005621_abnormal_cell_physiology0.81269942
152MP0005195_abnormal_posterior_eye0.80259749
153MP0003172_abnormal_lysosome_physiology0.79924080
154MP0002429_abnormal_blood_cell0.79898431
155MP0002405_respiratory_system_inflammati0.78846476
156MP0001929_abnormal_gametogenesis0.76686570
157MP0009672_abnormal_birth_weight0.76518445
158MP0002928_abnormal_bile_duct0.75475887
159MP0003436_decreased_susceptibility_to0.75398314
160MP0002452_abnormal_antigen_presenting0.73173460
161MP0003656_abnormal_erythrocyte_physiolo0.72282518
162MP0000685_abnormal_immune_system0.70654302
163MP0010094_abnormal_chromosome_stability0.70008819
164MP0003868_abnormal_feces_composition0.69974096
165MP0002085_abnormal_embryonic_tissue0.67737777
166MP0001145_abnormal_male_reproductive0.67614703
167MP0000313_abnormal_cell_death0.67524174

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.93485338
2Abnormality of the fingertips (HP:0001211)3.63708020
3Atonic seizures (HP:0010819)3.39899471
4Focal motor seizures (HP:0011153)3.37616454
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.07375046
6Drooling (HP:0002307)2.90808489
7Excessive salivation (HP:0003781)2.90808489
8Abnormality of the nasal septum (HP:0000419)2.87541055
9Degeneration of the lateral corticospinal tracts (HP:0002314)2.86705394
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.86705394
11Acute myeloid leukemia (HP:0004808)2.81669995
12Truncal obesity (HP:0001956)2.75015748
13Low anterior hairline (HP:0000294)2.67547463
14Papilledema (HP:0001085)2.60776498
15Volvulus (HP:0002580)2.59634986
16Obstructive sleep apnea (HP:0002870)2.57716165
17Focal seizures (HP:0007359)2.56579230
18Broad-based gait (HP:0002136)2.52740000
19Heterotopia (HP:0002282)2.51385668
20Thyroid carcinoma (HP:0002890)2.48817898
21Deep philtrum (HP:0002002)2.45597067
22Exotropia (HP:0000577)2.35751452
23Abnormality of salivation (HP:0100755)2.34417987
24Thickened helices (HP:0000391)2.32189710
25Cupped ear (HP:0000378)2.31265911
26Long eyelashes (HP:0000527)2.30094585
27Absence seizures (HP:0002121)2.29119695
28Oligodactyly (hands) (HP:0001180)2.28654733
29Facial hemangioma (HP:0000329)2.26031061
30Acute lymphatic leukemia (HP:0006721)2.24801764
31Abnormality of incisor morphology (HP:0011063)2.24006726
32Midline defect of the nose (HP:0004122)2.19612757
33Neonatal hypoglycemia (HP:0001998)2.19089922
34Slow saccadic eye movements (HP:0000514)2.18692429
35Obsessive-compulsive behavior (HP:0000722)2.18428708
36Widely spaced teeth (HP:0000687)2.16250382
37Absent speech (HP:0001344)2.13647449
38Chin dimple (HP:0010751)2.13206528
39Dysmetric saccades (HP:0000641)2.13192420
40Hyperventilation (HP:0002883)2.13025748
41Dialeptic seizures (HP:0011146)2.12078589
42Abnormality of the corticospinal tract (HP:0002492)2.11680941
43Morphological abnormality of the middle ear (HP:0008609)2.10484332
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.09467892
45Absent/shortened dynein arms (HP:0200106)2.09467892
46Epileptic encephalopathy (HP:0200134)2.09397888
47Anteriorly placed anus (HP:0001545)2.07995406
48Aqueductal stenosis (HP:0002410)2.06191194
49Febrile seizures (HP:0002373)2.05440712
50Abnormal hair whorl (HP:0010721)2.04530948
51Progressive cerebellar ataxia (HP:0002073)2.02342191
52Termporal pattern (HP:0011008)2.00823144
53Insidious onset (HP:0003587)2.00823144
54Hyperthyroidism (HP:0000836)2.00070105
55Abnormality of chromosome segregation (HP:0002916)1.99937903
56Deep palmar crease (HP:0006191)1.99398107
57Genital tract atresia (HP:0001827)1.98546274
58Abnormal ciliary motility (HP:0012262)1.97571410
59Transitional cell carcinoma of the bladder (HP:0006740)1.96546910
60Inappropriate behavior (HP:0000719)1.96219464
61Abnormal respiratory motile cilium morphology (HP:0005938)1.95877851
62Abnormal respiratory epithelium morphology (HP:0012253)1.95877851
63Vaginal atresia (HP:0000148)1.95806608
64Asymmetry of the thorax (HP:0001555)1.95418681
65Fatigue (HP:0012378)1.94297878
66Neoplasm of the oral cavity (HP:0100649)1.93881411
67Eczematoid dermatitis (HP:0000976)1.93375924
68Cystic hygroma (HP:0000476)1.93199584
69Overlapping toe (HP:0001845)1.92850873
70Fair hair (HP:0002286)1.91475465
71Supernumerary bones of the axial skeleton (HP:0009144)1.91360629
72Gait imbalance (HP:0002141)1.91249796
73Sandal gap (HP:0001852)1.90659300
74Hepatoblastoma (HP:0002884)1.90488357
75Absent eyebrow (HP:0002223)1.90238047
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88892777
77Abnormal respiratory motile cilium physiology (HP:0012261)1.87711240
78Arterial tortuosity (HP:0005116)1.87130898
79Narrow palate (HP:0000189)1.84924912
80Viral hepatitis (HP:0006562)1.84663655
81Aplasia cutis congenita (HP:0001057)1.83259331
82Sensory axonal neuropathy (HP:0003390)1.82211238
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81935079
84Recurrent bacterial skin infections (HP:0005406)1.81838892
85Genetic anticipation (HP:0003743)1.81831021
86Progressive inability to walk (HP:0002505)1.81427143
87Abnormality of the parietal bone (HP:0002696)1.81142977
88Bladder neoplasm (HP:0009725)1.80790152
89Bladder carcinoma (HP:0002862)1.80790152
90Subacute progressive viral hepatitis (HP:0006572)1.80153425
91Protruding tongue (HP:0010808)1.79884234
92T lymphocytopenia (HP:0005403)1.79092276
93Progressive external ophthalmoplegia (HP:0000590)1.78258232
94Lower limb asymmetry (HP:0100559)1.78189573
95Cutis marmorata (HP:0000965)1.77855305
96Vertebral arch anomaly (HP:0008438)1.77418065
97Increased nuchal translucency (HP:0010880)1.77117511
98Oligodactyly (HP:0012165)1.76953277
99Postural instability (HP:0002172)1.76927627
100Ankyloglossia (HP:0010296)1.76864756
101Medulloblastoma (HP:0002885)1.76136890
102Buphthalmos (HP:0000557)1.75267713
103Agnosia (HP:0010524)1.75068682
104Alacrima (HP:0000522)1.74186976
105Gastroesophageal reflux (HP:0002020)1.73986662
106Urinary bladder sphincter dysfunction (HP:0002839)1.72907298
107Parakeratosis (HP:0001036)1.72370975
108Basal cell carcinoma (HP:0002671)1.71937102
109Tapered finger (HP:0001182)1.71456077
110Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71449192
111Congenital primary aphakia (HP:0007707)1.71383962
112Spontaneous hematomas (HP:0007420)1.71313080
113Menstrual irregularities (HP:0000858)1.71061940
114Concave nail (HP:0001598)1.70269757
115Malignant gastrointestinal tract tumors (HP:0006749)1.70149208
116Gastrointestinal carcinoma (HP:0002672)1.70149208
117Peripheral hypomyelination (HP:0007182)1.69491055
118Missing ribs (HP:0000921)1.69431915
1192-3 toe syndactyly (HP:0004691)1.68414923
120Abnormality of binocular vision (HP:0011514)1.68301202
121Diplopia (HP:0000651)1.68301202
122Bowel incontinence (HP:0002607)1.67920120
123Humeroradial synostosis (HP:0003041)1.67415767
124Synostosis involving the elbow (HP:0003938)1.67415767
125Thick eyebrow (HP:0000574)1.67370226
126Blue irides (HP:0000635)1.67334363
127Sparse lateral eyebrow (HP:0005338)1.65571107
128Abnormal delayed hypersensitivity skin test (HP:0002963)1.65352153
129Broad palm (HP:0001169)1.64931238
130Action tremor (HP:0002345)1.64536146
131Sporadic (HP:0003745)1.64218161
132Increased circulating renin level (HP:0000848)1.64008008
133Germ cell neoplasia (HP:0100728)1.63783144
134Supernumerary ribs (HP:0005815)1.63180128
135Urethral obstruction (HP:0000796)1.62394692
136Heterochromia iridis (HP:0001100)1.62230068
137Medial flaring of the eyebrow (HP:0010747)1.61963906
138Hemiparesis (HP:0001269)1.61908022
139Relative macrocephaly (HP:0004482)1.60963919
140Cellulitis (HP:0100658)1.60447003
141Increased number of teeth (HP:0011069)1.60441490
142Recurrent viral infections (HP:0004429)1.59829798
143Decreased lacrimation (HP:0000633)1.59800004
144Vascular tortuosity (HP:0004948)1.59392124
145Curly hair (HP:0002212)1.59324428
146Chromsome breakage (HP:0040012)1.59289456
147Hamartoma (HP:0010566)1.58508880
148Disinhibition (HP:0000734)1.58475378
149Submucous cleft hard palate (HP:0000176)1.58102265
150Neoplasm of the thyroid gland (HP:0100031)1.58074616
151Abnormality of the nasolacrimal system (HP:0000614)1.57993662
152Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.57490797
153Megalencephaly (HP:0001355)1.57186360
154Panhypogammaglobulinemia (HP:0003139)1.56922139
155Lip pit (HP:0100267)1.56589540
156Stereotypic behavior (HP:0000733)1.56344436
157Hypoplasia of the iris (HP:0007676)1.56277158
158Uterine leiomyosarcoma (HP:0002891)1.55376260
159Leiomyosarcoma (HP:0100243)1.55376260
160Hypoplastic nipples (HP:0002557)1.55302539
161Cafe-au-lait spot (HP:0000957)1.54913234
162Abnormality of ocular smooth pursuit (HP:0000617)1.54388959
163Generalized tonic-clonic seizures (HP:0002069)1.53436528
164Renal hypoplasia (HP:0000089)1.53330534
165Abnormal large intestine physiology (HP:0012700)1.53029718
166Macroorchidism (HP:0000053)1.52577339
167Retinal dysplasia (HP:0007973)1.52147618
168Narrow nasal bridge (HP:0000446)1.51793569
169Nephrogenic diabetes insipidus (HP:0009806)1.51123782
170Neurofibrillary tangles (HP:0002185)1.50247154
171Cerebral inclusion bodies (HP:0100314)1.50076248
172Amblyopia (HP:0000646)1.49732877
173Truncal ataxia (HP:0002078)1.49013546
174Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.48970739
175Short 4th metacarpal (HP:0010044)1.48970739
176Dysmetria (HP:0001310)1.48890479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.12262266
2MAP3K102.43462830
3FGFR22.43119670
4STK392.36829602
5BRD42.22435647
6CASK2.16504810
7NTRK32.09735675
8BCR1.94752163
9EPHA41.86393128
10MKNK21.85519027
11RIPK41.84001787
12MARK11.73788910
13CAMK1D1.72652672
14KSR21.72352662
15UHMK11.69185210
16MAPK131.65071968
17NTRK21.64852107
18TYRO31.60502330
19TNIK1.60201922
20MKNK11.49078936
21MAP3K41.46868998
22BMPR21.44300081
23OXSR11.43330675
24KSR11.35933072
25IRAK21.35047709
26ERBB31.34959640
27WNK11.33672178
28MAP3K21.33303492
29EEF2K1.33153330
30MST41.30966004
31FGR1.30001687
32CSNK1A1L1.29028301
33MAP3K141.26511091
34ACVR1B1.25085350
35PKN11.22819345
36MARK21.21103766
37CDK31.19012669
38DYRK1A1.18494081
39CAMK1G1.16531103
40SIK21.12702527
41NUAK11.12346549
42FRK1.11706832
43PAK31.11691214
44LATS11.08188456
45IRAK11.07916525
46PLK21.06923737
47IRAK41.05950955
48CDK191.05797538
49CSNK1G21.02551867
50MELK1.02498132
51CSNK1G11.00118097
52CSNK1G30.98311485
53HIPK20.97580890
54TAOK10.96889467
55WNK40.96462189
56PASK0.92887685
57MAP3K90.92865991
58CAMK2B0.91791106
59CDK90.91433971
60PRPF4B0.89469467
61SGK2230.87762641
62SGK4940.87762641
63FES0.86180458
64EPHB20.86085485
65MINK10.84666046
66MAP3K120.84216084
67CDC70.84108650
68SGK20.83795943
69MAP3K10.83433201
70PAK60.81542676
71MAP2K70.80890147
72JAK10.80646672
73PDGFRB0.80476895
74CAMK2A0.80458460
75RET0.80075007
76GSK3A0.79788741
77STK110.79724966
78CDK50.78044145
79SIK30.77205847
80TAOK30.76014176
81STK380.75734721
82EPHB10.75710268
83CSK0.75387285
84CAMKK10.74522284
85RAF10.74098197
86FGFR40.74057948
87NEK60.73674846
88PRKCH0.73646516
89DMPK0.72698083
90SGK10.72575703
91BMPR1B0.72432668
92IKBKE0.72032515
93BRSK20.71416915
94MAP3K130.70688081
95PBK0.70672308
96DYRK30.70523058
97CDK60.69512406
98SIK10.69297940
99STK30.68841149
100FGFR30.68491564
101TNK20.65794364
102CDK40.64621968
103ITK0.64085236
104TEC0.64032746
105YES10.63372424
106STK40.63357750
107PRKCQ0.62929876
108MAP2K40.62386780
109CAMK2D0.61594946
110MTOR0.61395494
111PIM10.61083440
112MARK30.60526695
113PRKCE0.60097377
114FGFR10.59753806
115JAK20.59667205
116ICK0.59471394
117ROCK20.58034239
118PLK30.57533418
119BTK0.57043461
120CDK120.56982176
121MAP3K70.56890132
122MAPK100.56556528
123RIPK10.56368937
124DYRK1B0.54454909
125DDR20.53944342
126TRIB30.53672472
127SGK30.52155120
128PDK10.51140039
129SCYL20.50924757
130MAPK150.50637540
131CLK10.50293231
132STK240.50066912
133SRPK10.49868716
134RPS6KB10.49771219
135PRKG10.49762045
136ALK0.49269971
137SYK0.49181015
138MAP4K10.48225092
139PTK2B0.47865828
140WNK30.47415049
141CHEK10.45903814
142CAMKK20.44759115
143CAMK40.44277401
144CDK20.44202657
145HCK0.43932213
146TYK20.43762519
147TXK0.43417046
148RPS6KB20.43152063
149TRPM70.42971219
150NLK0.42208827
151CDK140.41437565
152AKT30.40183698
153EPHA30.39944704

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.52305589
2Long-term potentiation_Homo sapiens_hsa047202.00791108
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78554647
4Axon guidance_Homo sapiens_hsa043601.76823152
5Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76466990
6Glutamatergic synapse_Homo sapiens_hsa047241.75079316
7Long-term depression_Homo sapiens_hsa047301.72800428
8Amphetamine addiction_Homo sapiens_hsa050311.69921452
9Renin secretion_Homo sapiens_hsa049241.68506422
10Acute myeloid leukemia_Homo sapiens_hsa052211.64206636
11GABAergic synapse_Homo sapiens_hsa047271.58373066
12Morphine addiction_Homo sapiens_hsa050321.55239704
13Olfactory transduction_Homo sapiens_hsa047401.51236585
14Circadian entrainment_Homo sapiens_hsa047131.50499960
15Dopaminergic synapse_Homo sapiens_hsa047281.49261586
16mTOR signaling pathway_Homo sapiens_hsa041501.49198203
17Serotonergic synapse_Homo sapiens_hsa047261.48451154
18Inositol phosphate metabolism_Homo sapiens_hsa005621.42075122
19Dorso-ventral axis formation_Homo sapiens_hsa043201.40262695
20Phototransduction_Homo sapiens_hsa047441.37999194
21Renal cell carcinoma_Homo sapiens_hsa052111.37538978
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37307349
23Wnt signaling pathway_Homo sapiens_hsa043101.32722115
24Salivary secretion_Homo sapiens_hsa049701.31585849
25Prolactin signaling pathway_Homo sapiens_hsa049171.30206628
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28807626
27Thyroid cancer_Homo sapiens_hsa052161.27795747
28ErbB signaling pathway_Homo sapiens_hsa040121.26554668
29Taste transduction_Homo sapiens_hsa047421.23784632
30Cocaine addiction_Homo sapiens_hsa050301.23518575
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20874732
32Oxytocin signaling pathway_Homo sapiens_hsa049211.18624563
33Melanogenesis_Homo sapiens_hsa049161.18112223
34Notch signaling pathway_Homo sapiens_hsa043301.17631504
35T cell receptor signaling pathway_Homo sapiens_hsa046601.17135885
36Gastric acid secretion_Homo sapiens_hsa049711.16219594
37Cholinergic synapse_Homo sapiens_hsa047251.13123788
38Hepatitis B_Homo sapiens_hsa051611.11560185
39Estrogen signaling pathway_Homo sapiens_hsa049151.10574720
40Glioma_Homo sapiens_hsa052141.10118576
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08986771
42Measles_Homo sapiens_hsa051621.06374876
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05499057
44Prostate cancer_Homo sapiens_hsa052151.03691007
45Leishmaniasis_Homo sapiens_hsa051401.03426095
46cAMP signaling pathway_Homo sapiens_hsa040241.02796835
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99981400
48MAPK signaling pathway_Homo sapiens_hsa040100.99562478
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99341492
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97220550
51Gap junction_Homo sapiens_hsa045400.96788560
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95751559
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95476160
54GnRH signaling pathway_Homo sapiens_hsa049120.94303556
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93391222
56Hedgehog signaling pathway_Homo sapiens_hsa043400.93186747
57Choline metabolism in cancer_Homo sapiens_hsa052310.93171248
58Calcium signaling pathway_Homo sapiens_hsa040200.91116682
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.90234279
60Ras signaling pathway_Homo sapiens_hsa040140.89028884
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88347838
62MicroRNAs in cancer_Homo sapiens_hsa052060.88059361
63Colorectal cancer_Homo sapiens_hsa052100.87764710
64Cell cycle_Homo sapiens_hsa041100.87565605
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85801149
66Influenza A_Homo sapiens_hsa051640.85799000
67Hepatitis C_Homo sapiens_hsa051600.85449911
68Insulin secretion_Homo sapiens_hsa049110.84908586
69Oocyte meiosis_Homo sapiens_hsa041140.84728073
70Circadian rhythm_Homo sapiens_hsa047100.83461033
71Herpes simplex infection_Homo sapiens_hsa051680.81587677
72Viral carcinogenesis_Homo sapiens_hsa052030.81320912
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81081926
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81077258
75Basal cell carcinoma_Homo sapiens_hsa052170.80578217
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.80113040
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79631700
78TGF-beta signaling pathway_Homo sapiens_hsa043500.79603015
79Non-small cell lung cancer_Homo sapiens_hsa052230.79127298
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78433049
81Hippo signaling pathway_Homo sapiens_hsa043900.78304610
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.77748583
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77257322
84Insulin signaling pathway_Homo sapiens_hsa049100.76199839
85Endometrial cancer_Homo sapiens_hsa052130.76122621
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.75851157
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75074867
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74361579
89TNF signaling pathway_Homo sapiens_hsa046680.72342407
90Pancreatic secretion_Homo sapiens_hsa049720.71568050
91FoxO signaling pathway_Homo sapiens_hsa040680.71326221
92Rap1 signaling pathway_Homo sapiens_hsa040150.70815910
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70273180
94Small cell lung cancer_Homo sapiens_hsa052220.69755598
95Collecting duct acid secretion_Homo sapiens_hsa049660.69065743
96mRNA surveillance pathway_Homo sapiens_hsa030150.68774775
97Adherens junction_Homo sapiens_hsa045200.68480587
98Insulin resistance_Homo sapiens_hsa049310.68388351
99Pancreatic cancer_Homo sapiens_hsa052120.68154415
100Chemokine signaling pathway_Homo sapiens_hsa040620.67606363
101Toxoplasmosis_Homo sapiens_hsa051450.67115947
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66312182
103VEGF signaling pathway_Homo sapiens_hsa043700.65592639
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64874049
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64668307
106Type II diabetes mellitus_Homo sapiens_hsa049300.64418714
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.64238042
108HTLV-I infection_Homo sapiens_hsa051660.64155510
109B cell receptor signaling pathway_Homo sapiens_hsa046620.64061610
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62673109
111Synaptic vesicle cycle_Homo sapiens_hsa047210.62661383
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.62453920
113African trypanosomiasis_Homo sapiens_hsa051430.62390619
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62232446
115Graft-versus-host disease_Homo sapiens_hsa053320.62109926
116Ether lipid metabolism_Homo sapiens_hsa005650.61691455
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61277021
118Chronic myeloid leukemia_Homo sapiens_hsa052200.61132083
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60662072
120Lysine degradation_Homo sapiens_hsa003100.60486200
121Osteoclast differentiation_Homo sapiens_hsa043800.59953340
122HIF-1 signaling pathway_Homo sapiens_hsa040660.59916771
123Tuberculosis_Homo sapiens_hsa051520.59177339
124Tight junction_Homo sapiens_hsa045300.58992264
125Melanoma_Homo sapiens_hsa052180.58860211
126Proteoglycans in cancer_Homo sapiens_hsa052050.58776665
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58744194
128Alcoholism_Homo sapiens_hsa050340.58729985
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58099451
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57960697
131Autoimmune thyroid disease_Homo sapiens_hsa053200.56679888
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.56190373
133Pathways in cancer_Homo sapiens_hsa052000.55777069
134Thyroid hormone synthesis_Homo sapiens_hsa049180.55165072
135Platelet activation_Homo sapiens_hsa046110.52912083
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51848676
137Rheumatoid arthritis_Homo sapiens_hsa053230.50888736

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