WAPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.32494124
2nuclear pore organization (GO:0006999)5.97670278
3mitotic metaphase plate congression (GO:0007080)5.18603431
4pore complex assembly (GO:0046931)4.96510711
5metaphase plate congression (GO:0051310)4.65546794
6mitotic sister chromatid cohesion (GO:0007064)4.51799961
7protein localization to kinetochore (GO:0034501)4.45090390
8meiotic chromosome segregation (GO:0045132)4.44874518
9kinetochore organization (GO:0051383)4.30118620
10mitotic chromosome condensation (GO:0007076)4.27957237
11positive regulation of mitotic sister chromatid separation (GO:1901970)4.24816591
12positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.24816591
13positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.24816591
14monoubiquitinated protein deubiquitination (GO:0035520)4.20482442
15DNA unwinding involved in DNA replication (GO:0006268)4.17789560
16establishment of chromosome localization (GO:0051303)4.15622795
17mitotic nuclear envelope disassembly (GO:0007077)4.01135548
18protein localization to chromosome, centromeric region (GO:0071459)3.99529258
19attachment of spindle microtubules to kinetochore (GO:0008608)3.98929017
20histone H3-K36 demethylation (GO:0070544)3.97256701
21regulation of spindle organization (GO:0090224)3.95277294
22protein K6-linked ubiquitination (GO:0085020)3.87791892
23positive regulation of chromosome segregation (GO:0051984)3.80439358
24chromatin remodeling at centromere (GO:0031055)3.76540135
25kinetochore assembly (GO:0051382)3.73128739
26membrane disassembly (GO:0030397)3.71904311
27nuclear envelope disassembly (GO:0051081)3.71904311
28CENP-A containing nucleosome assembly (GO:0034080)3.70794906
29sister chromatid cohesion (GO:0007062)3.70749052
30pre-miRNA processing (GO:0031054)3.66129019
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.65526897
32regulation of RNA export from nucleus (GO:0046831)3.63969284
33sister chromatid segregation (GO:0000819)3.61661066
34mitotic sister chromatid segregation (GO:0000070)3.59268730
35DNA replication checkpoint (GO:0000076)3.56182576
36regulation of mitotic spindle organization (GO:0060236)3.55097065
37DNA replication-independent nucleosome assembly (GO:0006336)3.50752575
38DNA replication-independent nucleosome organization (GO:0034724)3.50752575
39regulation of sister chromatid cohesion (GO:0007063)3.49659111
40histone exchange (GO:0043486)3.45437412
41negative regulation of DNA-dependent DNA replication (GO:2000104)3.40515164
42microtubule depolymerization (GO:0007019)3.33828344
43regulation of helicase activity (GO:0051095)3.33711469
44dosage compensation (GO:0007549)3.32461075
45replication fork processing (GO:0031297)3.32438949
46cytoplasmic mRNA processing body assembly (GO:0033962)3.30435896
47DNA replication initiation (GO:0006270)3.29327850
48histone H2A monoubiquitination (GO:0035518)3.28791651
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27926915
50regulation of histone H3-K9 methylation (GO:0051570)3.27893542
51chromosome segregation (GO:0007059)3.27555196
52negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.23821642
53protein localization to chromosome (GO:0034502)3.23181705
54regulation of centriole replication (GO:0046599)3.21396937
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17261105
56spindle checkpoint (GO:0031577)3.16332372
57resolution of meiotic recombination intermediates (GO:0000712)3.16285804
58inner cell mass cell proliferation (GO:0001833)3.12851298
59double-strand break repair via nonhomologous end joining (GO:0006303)3.09224697
60non-recombinational repair (GO:0000726)3.09224697
61positive regulation of histone H3-K4 methylation (GO:0051571)3.08238463
62regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06498264
63regulation of chromosome segregation (GO:0051983)3.04758253
64chromatin assembly or disassembly (GO:0006333)3.03683588
65DNA replication-dependent nucleosome organization (GO:0034723)3.03378452
66DNA replication-dependent nucleosome assembly (GO:0006335)3.03378452
67IMP biosynthetic process (GO:0006188)3.03294661
68regulation of centrosome cycle (GO:0046605)3.02167329
69negative regulation of histone methylation (GO:0031061)3.00552602
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00191710
71DNA strand elongation involved in DNA replication (GO:0006271)2.98770244
72somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97537557
73somatic hypermutation of immunoglobulin genes (GO:0016446)2.97537557
74DNA geometric change (GO:0032392)2.96548331
75DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.95187263
76DNA duplex unwinding (GO:0032508)2.95057665
77histone H2B ubiquitination (GO:0033523)2.94482427
78DNA synthesis involved in DNA repair (GO:0000731)2.93757869
79regulation of double-strand break repair (GO:2000779)2.92554874
80DNA topological change (GO:0006265)2.92154944
81ATP-dependent chromatin remodeling (GO:0043044)2.92067709
82regulation of double-strand break repair via homologous recombination (GO:0010569)2.91261482
83ribosome assembly (GO:0042255)2.90902174
84regulation of protein polyubiquitination (GO:1902914)2.90564926
85histone H3-K9 demethylation (GO:0033169)2.90031574
86regulation of histone methylation (GO:0031060)2.89553071
87regulation of mitotic spindle checkpoint (GO:1903504)2.89498340
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89498340
89DNA strand elongation (GO:0022616)2.88859665
90positive regulation of histone methylation (GO:0031062)2.88387606
91regulation of sister chromatid segregation (GO:0033045)2.88283696
92regulation of mitotic sister chromatid separation (GO:0010965)2.88283696
93regulation of mitotic sister chromatid segregation (GO:0033047)2.88283696
94mRNA stabilization (GO:0048255)2.88159529
95RNA stabilization (GO:0043489)2.88159529
96reciprocal DNA recombination (GO:0035825)2.85608712
97reciprocal meiotic recombination (GO:0007131)2.85608712
98negative regulation of DNA repair (GO:0045738)2.83947461
99embryonic process involved in female pregnancy (GO:0060136)2.83640808
100histone demethylation (GO:0016577)2.83621193
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.83181851
102nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.82913023
103histone lysine demethylation (GO:0070076)2.82863625
104phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.81237345
105regulation of meiosis I (GO:0060631)2.81041697
106nuclear envelope organization (GO:0006998)2.79537564
107NLS-bearing protein import into nucleus (GO:0006607)2.79196443
108DNA damage response, signal transduction resulting in transcription (GO:0042772)2.78441329
109mismatch repair (GO:0006298)2.77217623
110mitotic recombination (GO:0006312)2.76382455
111histone mRNA catabolic process (GO:0071044)2.75868686
112regulation of DNA endoreduplication (GO:0032875)2.75697238
113DNA conformation change (GO:0071103)2.75008440
114negative regulation of fibroblast apoptotic process (GO:2000270)2.74780017
115regulation of establishment of cell polarity (GO:2000114)2.74739366
116purine nucleobase biosynthetic process (GO:0009113)2.74167463
117mitotic spindle checkpoint (GO:0071174)2.73656564
118regulation of nucleobase-containing compound transport (GO:0032239)2.73315577
119chromatin assembly (GO:0031497)2.71974264
120DNA packaging (GO:0006323)2.71838332
121synapsis (GO:0007129)2.71799968
122regulation of DNA methylation (GO:0044030)2.70518710
123protein export from nucleus (GO:0006611)2.69025403
124interkinetic nuclear migration (GO:0022027)2.66654855
125nucleus organization (GO:0006997)2.64884842
126regulation of histone H3-K4 methylation (GO:0051569)2.63440001
127telomere maintenance via recombination (GO:0000722)2.63307312
128negative regulation of chromosome segregation (GO:0051985)2.59833179
129peptidyl-lysine trimethylation (GO:0018023)2.58987100
130definitive hemopoiesis (GO:0060216)2.58547411
131mitotic G2/M transition checkpoint (GO:0044818)2.58446357
132regulation of histone H3-K27 methylation (GO:0061085)2.56157113
133regulation of centrosome duplication (GO:0010824)2.55561978
134negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.54877155
135negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.54877155
136negative regulation of mitotic sister chromatid segregation (GO:0033048)2.54877155
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.54877155
138negative regulation of sister chromatid segregation (GO:0033046)2.54877155
139hepatocyte apoptotic process (GO:0097284)2.53929016
140telomere maintenance via semi-conservative replication (GO:0032201)2.51196089
141chromosome condensation (GO:0030261)2.49967398
142regulation of chromatin silencing (GO:0031935)2.49060337
143regulation of DNA damage checkpoint (GO:2000001)2.48308904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.36763101
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.22356541
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.62692326
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.23820699
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.13010908
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.71824778
7AR_21909140_ChIP-Seq_LNCAP_Human2.57338417
8E2F1_21310950_ChIP-Seq_MCF-7_Human2.48793876
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.44370627
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10725397
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08705351
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.06510380
13E2F7_22180533_ChIP-Seq_HELA_Human10.5039475
14NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97777554
15RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92520895
16GATA1_22025678_ChIP-Seq_K562_Human1.88181889
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87187528
18MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83960617
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83211232
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80164185
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71695193
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71629372
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68413680
24ELK1_19687146_ChIP-ChIP_HELA_Human1.59503727
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58590663
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53862761
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52802374
28VDR_23849224_ChIP-Seq_CD4+_Human1.52040708
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50934170
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46684147
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45986227
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45587137
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.42896015
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42249679
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41658131
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40454923
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39476334
38KDM5A_27292631_Chip-Seq_BREAST_Human1.38327574
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37572421
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34922075
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32961046
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32745777
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32573361
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32160791
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30052411
46FOXP3_21729870_ChIP-Seq_TREG_Human1.27606794
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25101624
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23946090
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23249813
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22173841
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20901808
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19190754
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.18493744
54SPI1_23547873_ChIP-Seq_NB4_Human1.18425823
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17660024
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17533097
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15349550
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14259920
59MYC_22102868_ChIP-Seq_BL_Human1.13860032
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12563654
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11451601
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11446205
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11446205
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11446205
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10877061
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10576499
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10138436
68XRN2_22483619_ChIP-Seq_HELA_Human1.10008182
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09518352
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08388185
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08356711
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.07441084
73SCL_19346495_ChIP-Seq_HPC-7_Human1.07084672
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.05666455
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01857085
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01564102
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01006838
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.00680833
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.00577553
80PU_27001747_Chip-Seq_BMDM_Mouse1.00377042
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99570387
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98740030
83KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96908817
84ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95607783
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95407190
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94760394
87TFEB_21752829_ChIP-Seq_HELA_Human0.94631487
88ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94332451
89TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94312542
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93985656
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93692247
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93569944
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93569944
94MYB_26560356_Chip-Seq_TH1_Human0.93523845
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92503742
96CIITA_25753668_ChIP-Seq_RAJI_Human0.91085906
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90912990
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90879746
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90620738
100DCP1A_22483619_ChIP-Seq_HELA_Human0.90378492
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89336273
102ETS1_20019798_ChIP-Seq_JURKAT_Human0.89233263
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88445389
104GABP_19822575_ChIP-Seq_HepG2_Human0.88240974
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87994405
106NANOG_21062744_ChIP-ChIP_HESCs_Human0.87782003
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86595972
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85301498
109TTF2_22483619_ChIP-Seq_HELA_Human0.85249244
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85173846
111TCF7_22412390_ChIP-Seq_EML_Mouse0.84794185
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84604213
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.84411947
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83891201
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80481377
116PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80085669
117EWS_26573619_Chip-Seq_HEK293_Human0.78387151
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78301788
119MYC_18940864_ChIP-ChIP_HL60_Human0.77277221
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75333268
121ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75298760
122CHD1_26751641_Chip-Seq_LNCaP_Human0.75287650
123MYB_26560356_Chip-Seq_TH2_Human0.75086468
124JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.74085477
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73955839
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73681352
127SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.72490752
128PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71928380
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.70193100
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.68978879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.19392365
2MP0003693_abnormal_embryo_hatching3.98299140
3MP0010094_abnormal_chromosome_stability3.80807641
4MP0003111_abnormal_nucleus_morphology3.41357075
5MP0003077_abnormal_cell_cycle3.26819755
6MP0008877_abnormal_DNA_methylation2.98015998
7MP0008007_abnormal_cellular_replicative2.93324453
8MP0004957_abnormal_blastocyst_morpholog2.89218667
9MP0008058_abnormal_DNA_repair2.84678573
10MP0010307_abnormal_tumor_latency2.81273022
11MP0010352_gastrointestinal_tract_polyps2.21578971
12MP0002396_abnormal_hematopoietic_system2.00038998
13MP0000350_abnormal_cell_proliferation1.93808197
14MP0005076_abnormal_cell_differentiation1.90637216
15MP0001730_embryonic_growth_arrest1.89088964
16MP0003656_abnormal_erythrocyte_physiolo1.81735860
17MP0003787_abnormal_imprinting1.68213640
18MP0001672_abnormal_embryogenesis/_devel1.68057930
19MP0005380_embryogenesis_phenotype1.68057930
20MP0003786_premature_aging1.67493359
21MP0002877_abnormal_melanocyte_morpholog1.67097479
22MP0002009_preneoplasia1.58542932
23MP0004264_abnormal_extraembryonic_tissu1.53841284
24MP0003984_embryonic_growth_retardation1.51690324
25MP0002086_abnormal_extraembryonic_tissu1.49928294
26MP0004808_abnormal_hematopoietic_stem1.49796277
27MP0003890_abnormal_embryonic-extraembry1.49546945
28MP0002088_abnormal_embryonic_growth/wei1.48463603
29MP0005451_abnormal_body_composition1.47852773
30MP0003123_paternal_imprinting1.47729123
31MP0001697_abnormal_embryo_size1.46531798
32MP0003300_gastrointestinal_ulcer1.43762541
33MP0008932_abnormal_embryonic_tissue1.43483899
34MP0002084_abnormal_developmental_patter1.40260129
35MP0004197_abnormal_fetal_growth/weight/1.39405566
36MP0002210_abnormal_sex_determination1.37567889
37MP0003121_genomic_imprinting1.37099449
38MP0001545_abnormal_hematopoietic_system1.35637037
39MP0005397_hematopoietic_system_phenotyp1.35637037
40MP0002085_abnormal_embryonic_tissue1.32907619
41MP0003763_abnormal_thymus_physiology1.31979735
42MP0003718_maternal_effect1.31071005
43MP0000490_abnormal_crypts_of1.30621395
44MP0003221_abnormal_cardiomyocyte_apopto1.30495475
45MP0003303_peritoneal_inflammation1.29372452
46MP0003941_abnormal_skin_development1.24735336
47MP0002796_impaired_skin_barrier1.23318245
48MP0009053_abnormal_anal_canal1.22100649
49MP0001929_abnormal_gametogenesis1.21861879
50MP0006292_abnormal_olfactory_placode1.21756538
51MP0001119_abnormal_female_reproductive1.20117212
52MP0002019_abnormal_tumor_incidence1.20068228
53MP0004233_abnormal_muscle_weight1.18476868
54MP0000015_abnormal_ear_pigmentation1.14162334
55MP0001145_abnormal_male_reproductive1.13541132
56MP0005408_hypopigmentation1.13443584
57MP0002006_tumorigenesis1.13214864
58MP0003937_abnormal_limbs/digits/tail_de1.13130369
59MP0002080_prenatal_lethality1.12195831
60MP0000653_abnormal_sex_gland1.09350141
61MP0000313_abnormal_cell_death1.08639693
62MP0003705_abnormal_hypodermis_morpholog1.08301751
63MP0003091_abnormal_cell_migration1.07884932
64MP0002166_altered_tumor_susceptibility1.07216805
65MP0003567_abnormal_fetal_cardiomyocyte1.05831783
66MP0010234_abnormal_vibrissa_follicle1.05150781
67MP0005501_abnormal_skin_physiology1.02761597
68MP0001835_abnormal_antigen_presentation1.02293417
69MP0001915_intracranial_hemorrhage1.02013500
70MP0000566_synostosis1.01563292
71MP0001293_anophthalmia1.01477745
72MP0008995_early_reproductive_senescence1.00225328
73MP0005409_darkened_coat_color0.99768742
74MP0000627_abnormal_mammary_gland0.96475683
75MP0005384_cellular_phenotype0.96139289
76MP0001661_extended_life_span0.95264150
77MP0005367_renal/urinary_system_phenotyp0.94605256
78MP0000516_abnormal_urinary_system0.94605256
79MP0009333_abnormal_splenocyte_physiolog0.94315918
80MP0008260_abnormal_autophagy0.94170390
81MP0009703_decreased_birth_body0.90096869
82MP0002398_abnormal_bone_marrow0.89297337
83MP0002160_abnormal_reproductive_system0.87348608
84MP0005647_abnormal_sex_gland0.87003258
85MP0001800_abnormal_humoral_immune0.86694329
86MP0005389_reproductive_system_phenotype0.85211537
87MP0001286_abnormal_eye_development0.84898305
88MP0003315_abnormal_perineum_morphology0.83809268
89MP0000432_abnormal_head_morphology0.83676280
90MP0000703_abnormal_thymus_morphology0.83325107
91MP0009697_abnormal_copulation0.81052664
92MP0001853_heart_inflammation0.80179769
93MP0000427_abnormal_hair_cycle0.80043138
94MP0003828_pulmonary_edema0.79459526
95MP0009672_abnormal_birth_weight0.79186559
96MP0000689_abnormal_spleen_morphology0.78827161
97MP0003566_abnormal_cell_adhesion0.78628852
98MP0002429_abnormal_blood_cell0.78362131
99MP0003936_abnormal_reproductive_system0.78247761
100MP0003699_abnormal_female_reproductive0.77556935
101MP0000716_abnormal_immune_system0.77488941
102MP0004947_skin_inflammation0.77408184
103MP0001849_ear_inflammation0.77171654
104MP0005174_abnormal_tail_pigmentation0.76329459
105MP0005621_abnormal_cell_physiology0.75594048
106MP0000377_abnormal_hair_follicle0.75360306
107MP0003943_abnormal_hepatobiliary_system0.74601151
108MP0005464_abnormal_platelet_physiology0.74259751
109MP0002722_abnormal_immune_system0.74205552
110MP0010030_abnormal_orbit_morphology0.73476487
111MP0000383_abnormal_hair_follicle0.73260860
112MP0000371_diluted_coat_color0.73100697
113MP0005023_abnormal_wound_healing0.72686172
114MP0001216_abnormal_epidermal_layer0.71857258
115MP0000428_abnormal_craniofacial_morphol0.71181451
116MP0001919_abnormal_reproductive_system0.71003600
117MP0000569_abnormal_digit_pigmentation0.70029286
118MP0002452_abnormal_antigen_presenting0.68891867
119MP0003453_abnormal_keratinocyte_physiol0.68795985
120MP0005666_abnormal_adipose_tissue0.68598352
121MP0002420_abnormal_adaptive_immunity0.67177712
122MP0005310_abnormal_salivary_gland0.66758221
123MP0005248_abnormal_Harderian_gland0.66598867
124MP0003950_abnormal_plasma_membrane0.66500551
125MP0005395_other_phenotype0.66378579
126MP0002060_abnormal_skin_morphology0.66324815
127MP0002405_respiratory_system_inflammati0.66207196
128MP0002697_abnormal_eye_size0.65547523
129MP0003448_altered_tumor_morphology0.65263699
130MP0004185_abnormal_adipocyte_glucose0.65251419
131MP0002092_abnormal_eye_morphology0.64883209
132MP0010678_abnormal_skin_adnexa0.64573613

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.24208568
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.85512618
3Birth length less than 3rd percentile (HP:0003561)4.14236184
4Abnormality of chromosome stability (HP:0003220)3.82254279
5Abnormality of the fingertips (HP:0001211)3.63806155
6Papillary thyroid carcinoma (HP:0002895)3.47724904
7Ectopic kidney (HP:0000086)3.26798787
8Volvulus (HP:0002580)3.21359309
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.17213438
10Meckel diverticulum (HP:0002245)3.13947884
11Abnormality of the preputium (HP:0100587)3.13596249
12Acute myeloid leukemia (HP:0004808)3.07530793
13Impulsivity (HP:0100710)3.04909266
14Prostate neoplasm (HP:0100787)2.96412619
15Abnormality of the ileum (HP:0001549)2.95601914
16Abnormality of the labia minora (HP:0012880)2.89253307
17Myelodysplasia (HP:0002863)2.87512284
18Patellar aplasia (HP:0006443)2.81055225
19Facial hemangioma (HP:0000329)2.78538143
20Lip pit (HP:0100267)2.71719070
21Spinal cord lesions (HP:0100561)2.67403885
22Syringomyelia (HP:0003396)2.67403885
23Breast hypoplasia (HP:0003187)2.66673995
24Subacute progressive viral hepatitis (HP:0006572)2.58416185
25Aplasia/Hypoplasia of the patella (HP:0006498)2.57219698
26Duodenal stenosis (HP:0100867)2.57106852
27Small intestinal stenosis (HP:0012848)2.57106852
28Hypochromic microcytic anemia (HP:0004840)2.55226187
29Curly hair (HP:0002212)2.54891527
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54701588
31Abnormal spermatogenesis (HP:0008669)2.54213472
32Capillary hemangiomas (HP:0005306)2.53279859
33Medulloblastoma (HP:0002885)2.52744217
34Clubbing of toes (HP:0100760)2.49025137
35Transitional cell carcinoma of the bladder (HP:0006740)2.41906359
36Nephroblastoma (Wilms tumor) (HP:0002667)2.41835741
37Acute lymphatic leukemia (HP:0006721)2.39971910
38Deep philtrum (HP:0002002)2.36425967
39Thyroid carcinoma (HP:0002890)2.35441255
40Bladder carcinoma (HP:0002862)2.35166780
41Bladder neoplasm (HP:0009725)2.35166780
42Azoospermia (HP:0000027)2.32909196
43Biliary tract neoplasm (HP:0100574)2.31683513
44Shawl scrotum (HP:0000049)2.31026844
45Short middle phalanx of the 5th finger (HP:0004220)2.26965919
46Progressive external ophthalmoplegia (HP:0000590)2.23310799
47Embryonal renal neoplasm (HP:0011794)2.22519834
48Rhabdomyosarcoma (HP:0002859)2.22144761
49Amaurosis fugax (HP:0100576)2.20257794
50Leiomyosarcoma (HP:0100243)2.19975536
51Uterine leiomyosarcoma (HP:0002891)2.19975536
52Abnormality of the carotid arteries (HP:0005344)2.19704147
53Sloping forehead (HP:0000340)2.19570777
54Low anterior hairline (HP:0000294)2.19065994
55Neonatal hypoglycemia (HP:0001998)2.18702404
56Basal cell carcinoma (HP:0002671)2.18688081
57Deep palmar crease (HP:0006191)2.17518597
58Viral hepatitis (HP:0006562)2.16577613
59Overlapping toe (HP:0001845)2.15390796
60Ependymoma (HP:0002888)2.11981330
61Abnormality of the duodenum (HP:0002246)2.11818622
62Neoplasm of the oral cavity (HP:0100649)2.11427256
63Abnormal foot bone ossification (HP:0010675)2.11179559
64Long eyelashes (HP:0000527)2.11133864
65Absent radius (HP:0003974)2.10125150
66Sandal gap (HP:0001852)2.09603728
67IgA deficiency (HP:0002720)2.08962396
68Cafe-au-lait spot (HP:0000957)2.08313799
69Prominent nose (HP:0000448)2.07333686
70Deviation of the thumb (HP:0009603)2.07289646
71Fatigue (HP:0012378)2.04906882
72Supernumerary spleens (HP:0009799)2.03834046
73T lymphocytopenia (HP:0005403)2.03661815
74Flat acetabular roof (HP:0003180)2.02246797
75Recurrent viral infections (HP:0004429)2.01220328
7611 pairs of ribs (HP:0000878)2.01029580
77Bone marrow hypocellularity (HP:0005528)1.99787240
78Agnosia (HP:0010524)1.98770272
79Dysmetric saccades (HP:0000641)1.96605378
80Abnormality of the prostate (HP:0008775)1.96557898
81Abnormal lung lobation (HP:0002101)1.94643917
82Abnormal biliary tract morphology (HP:0012440)1.94639067
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94388744
84Short 4th metacarpal (HP:0010044)1.94388744
85Ankyloglossia (HP:0010296)1.92779683
86Short thumb (HP:0009778)1.92627412
87Abnormality of the anterior horn cell (HP:0006802)1.90174018
88Degeneration of anterior horn cells (HP:0002398)1.90174018
89Absent forearm bone (HP:0003953)1.89985618
90Aplasia involving forearm bones (HP:0009822)1.89985618
91Abnormality of the left ventricular outflow tract (HP:0011103)1.88947581
92Subaortic stenosis (HP:0001682)1.88947581
93Abnormality of the nasal septum (HP:0000419)1.85921088
94Acanthocytosis (HP:0001927)1.84490484
95Cystic hygroma (HP:0000476)1.83756591
96Proximal placement of thumb (HP:0009623)1.83043305
97Sparse lateral eyebrow (HP:0005338)1.82873440
98Carpal bone hypoplasia (HP:0001498)1.82694836
99Long clavicles (HP:0000890)1.82195266
100Selective tooth agenesis (HP:0001592)1.81902957
101Neoplasm of the small intestine (HP:0100833)1.80876324
102Entropion (HP:0000621)1.80608073
103Absent thumb (HP:0009777)1.80560332
104Colon cancer (HP:0003003)1.78995998
105Embryonal neoplasm (HP:0002898)1.78948165
106Cutis marmorata (HP:0000965)1.78443729
107Osteolytic defects of the phalanges of the hand (HP:0009771)1.77571165
108Osteolytic defects of the hand bones (HP:0009699)1.77571165
109Abnormality of chromosome segregation (HP:0002916)1.76817719
110Autoimmune hemolytic anemia (HP:0001890)1.76681305
111Termporal pattern (HP:0011008)1.76531930
112Insidious onset (HP:0003587)1.76531930
113Malignant gastrointestinal tract tumors (HP:0006749)1.74869969
114Gastrointestinal carcinoma (HP:0002672)1.74869969
115Skull defect (HP:0001362)1.74073926
116Wide nose (HP:0000445)1.73991544
117Narrow palate (HP:0000189)1.73760063
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.72830401
119Abnormality of T cell number (HP:0011839)1.72147950
120Arteriovenous malformation (HP:0100026)1.70888364
121Broad palm (HP:0001169)1.70883831
122Truncal obesity (HP:0001956)1.70035343
123Neoplasm of striated muscle (HP:0009728)1.69996085
124Multiple enchondromatosis (HP:0005701)1.69983588
125Poikiloderma (HP:0001029)1.69926051
126Astrocytoma (HP:0009592)1.69441398
127Abnormality of the astrocytes (HP:0100707)1.69441398
128Blepharitis (HP:0000498)1.69216010
129Hypoplastic labia majora (HP:0000059)1.68851950
130Renal cell carcinoma (HP:0005584)1.68291737
131Cubitus valgus (HP:0002967)1.67280814
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.67006871
133Breast carcinoma (HP:0003002)1.66143021
134Squamous cell carcinoma (HP:0002860)1.65987675
135Relative macrocephaly (HP:0004482)1.65738629
136Oligodactyly (HP:0012165)1.65718291
137Urethral obstruction (HP:0000796)1.65274358
138Glioma (HP:0009733)1.65146305
139Absent frontal sinuses (HP:0002688)1.64737153
140IgM deficiency (HP:0002850)1.64520618
141Asymmetry of the thorax (HP:0001555)1.64177506
142Cutaneous melanoma (HP:0012056)1.63945636
143Rib fusion (HP:0000902)1.63148667
144Oral leukoplakia (HP:0002745)1.62424264
145Abnormality of oral frenula (HP:0000190)1.62250013
146Conjunctival telangiectasia (HP:0000524)1.62152532
147Uterine neoplasm (HP:0010784)1.62075321
148Thickened calvaria (HP:0002684)1.61846709
149Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61812153
150Increased nuchal translucency (HP:0010880)1.61651326
151Osteomyelitis (HP:0002754)1.61141278
152Stillbirth (HP:0003826)1.60928488
153Missing ribs (HP:0000921)1.58185214
154Oligodactyly (hands) (HP:0001180)1.58008884
155Abnormality of the hepatic vasculature (HP:0006707)1.57424352
156Neoplasm of the pancreas (HP:0002894)1.57225196
157Intestinal fistula (HP:0100819)1.57189019
158Metaphyseal cupping (HP:0003021)1.57152834
159Heterotopia (HP:0002282)1.56308286
160Tracheoesophageal fistula (HP:0002575)1.55933610
161Abnormality of lateral ventricle (HP:0030047)1.54922033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.20183607
2CDC74.15836542
3CDK123.56533773
4STK38L2.90660135
5BRSK22.69445915
6SRPK12.61794624
7PLK42.61532224
8MAP3K102.54656293
9NEK22.49057241
10WEE12.38706971
11SCYL22.36314650
12STK32.31062711
13TTK2.17358769
14FRK1.87317385
15EIF2AK11.82174350
16PLK31.81119662
17CAMK1G1.77548423
18NUAK11.75717704
19ZAK1.75413345
20PLK11.72447126
21PRPF4B1.71234120
22CHEK21.69845940
23MKNK21.67045077
24ACVR1B1.59824919
25ATR1.56336674
26AURKB1.53860646
27STK41.47816673
28MKNK11.47134328
29TAF11.46391830
30LATS21.40740932
31CHEK11.40436504
32ATM1.38810136
33BRD41.34302310
34NEK11.33982161
35AKT31.33209788
36PIM11.32676788
37PBK1.30899329
38CDK71.29668412
39STK101.29058487
40PNCK1.28158593
41SMG11.26064197
42WNK11.25653446
43CDK61.23111154
44CDK41.21362065
45RPS6KB21.17973769
46MELK1.17205242
47EPHA21.15303200
48BUB11.15261395
49CHUK1.14694212
50NEK91.14571754
51VRK11.13128988
52STK241.12175166
53JAK31.09786171
54MAP3K131.06535330
55RPS6KA41.01420839
56FGFR30.99830355
57ERBB40.98961283
58TXK0.96036681
59CDK90.95030438
60MAP3K140.91792475
61DYRK30.91531663
62BRSK10.90978574
63CDK20.89568266
64MAP3K60.89293013
65RAF10.87860280
66MAP2K30.87778850
67CLK10.86758073
68PASK0.86446018
69MST40.85557055
70EIF2AK30.83135681
71KSR20.83000765
72PDGFRA0.82887914
73SGK20.82633140
74MARK30.80738548
75BRAF0.80160886
76MAP3K90.79465086
77TRPM70.77145193
78TAOK30.76864025
79MAP3K20.74567799
80MAP3K80.73245242
81CDK10.73154045
82TSSK60.72622072
83EEF2K0.69363858
84CAMK1D0.68033145
85FGR0.67203931
86EIF2AK20.66669936
87JAK10.65363969
88CDK80.64651233
89PIK3CG0.62489474
90SGK30.62453356
91BTK0.62004757
92CDK30.61028311
93FGFR10.60995919
94CSK0.59628587
95FGFR40.59480679
96BMPR20.56907971
97IRAK30.56050958
98FLT30.54850869
99KSR10.54337990
100MTOR0.53934821
101ERBB30.52771433
102YES10.51989672
103MAP3K30.51317011
104MAPK140.51183821
105IRAK10.50238680
106RET0.49706632
107MAP3K50.49009201
108MET0.48480028
109ICK0.48111977
110NEK60.47379814
111IKBKB0.46592046
112CSF1R0.46454987
113TEC0.45678563
114RPS6KB10.44968206
115AURKA0.44511299
116NLK0.44111079
117IKBKE0.44007121
118PKN20.43657946
119DMPK0.43624431
120AKT10.43580138
121PRKAA10.42488315
122CSNK1D0.39090924
123RPS6KA50.39039832
124MAP4K10.38613651
125TLK10.38566855
126TGFBR10.38335154
127ALK0.37700731
128PRKDC0.36833617
129CSNK2A10.35217282
130CSNK2A20.34894489
131MAPK10.33971856
132GSK3B0.28544339
133EPHA30.28131661
134PRKAA20.26905765
135PDGFRB0.26683053
136PRKCI0.26093712

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46359708
2Cell cycle_Homo sapiens_hsa041103.19668234
3Mismatch repair_Homo sapiens_hsa034303.18503884
4DNA replication_Homo sapiens_hsa030303.14961936
5Fanconi anemia pathway_Homo sapiens_hsa034602.93470547
6RNA transport_Homo sapiens_hsa030132.77296495
7Homologous recombination_Homo sapiens_hsa034402.77198747
8Basal transcription factors_Homo sapiens_hsa030222.60139279
9One carbon pool by folate_Homo sapiens_hsa006702.51298933
10Non-homologous end-joining_Homo sapiens_hsa034502.49381407
11RNA degradation_Homo sapiens_hsa030182.23017390
12Nucleotide excision repair_Homo sapiens_hsa034202.18224860
13Spliceosome_Homo sapiens_hsa030402.15333331
14Base excision repair_Homo sapiens_hsa034102.14383276
15p53 signaling pathway_Homo sapiens_hsa041152.12242992
16mRNA surveillance pathway_Homo sapiens_hsa030152.10522625
17RNA polymerase_Homo sapiens_hsa030202.01061955
18B cell receptor signaling pathway_Homo sapiens_hsa046621.62691212
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56769864
20Herpes simplex infection_Homo sapiens_hsa051681.53624599
21Systemic lupus erythematosus_Homo sapiens_hsa053221.40539473
22MicroRNAs in cancer_Homo sapiens_hsa052061.39522425
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38010186
24Renal cell carcinoma_Homo sapiens_hsa052111.34121013
25Viral carcinogenesis_Homo sapiens_hsa052031.30098282
26Pyrimidine metabolism_Homo sapiens_hsa002401.29735051
27TGF-beta signaling pathway_Homo sapiens_hsa043501.24501330
28Selenocompound metabolism_Homo sapiens_hsa004501.22258955
29Thyroid cancer_Homo sapiens_hsa052161.21747403
30Antigen processing and presentation_Homo sapiens_hsa046121.19204921
31Small cell lung cancer_Homo sapiens_hsa052221.14132853
32Lysine degradation_Homo sapiens_hsa003101.12467036
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11933937
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10617935
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.10466191
36Inositol phosphate metabolism_Homo sapiens_hsa005621.09941329
37Adherens junction_Homo sapiens_hsa045201.07890042
38Epstein-Barr virus infection_Homo sapiens_hsa051691.06365704
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05354723
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04176193
41ErbB signaling pathway_Homo sapiens_hsa040120.96900045
42HTLV-I infection_Homo sapiens_hsa051660.95731502
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94684237
44Dorso-ventral axis formation_Homo sapiens_hsa043200.93714642
45Measles_Homo sapiens_hsa051620.93570066
46Vitamin B6 metabolism_Homo sapiens_hsa007500.91840756
47Glioma_Homo sapiens_hsa052140.89233499
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87907330
49Prostate cancer_Homo sapiens_hsa052150.87740480
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86916186
51Influenza A_Homo sapiens_hsa051640.86736107
52Osteoclast differentiation_Homo sapiens_hsa043800.84410509
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81427879
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81029592
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.78335307
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.76660412
57Hepatitis B_Homo sapiens_hsa051610.75425164
58FoxO signaling pathway_Homo sapiens_hsa040680.74826365
59Primary immunodeficiency_Homo sapiens_hsa053400.73482072
60Purine metabolism_Homo sapiens_hsa002300.73343600
61Oocyte meiosis_Homo sapiens_hsa041140.71930209
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.71890280
63Pancreatic cancer_Homo sapiens_hsa052120.71419231
64Platelet activation_Homo sapiens_hsa046110.69703398
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68103205
66VEGF signaling pathway_Homo sapiens_hsa043700.67567843
67Shigellosis_Homo sapiens_hsa051310.66605707
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.66341452
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66283011
70Hippo signaling pathway_Homo sapiens_hsa043900.66053774
71Chronic myeloid leukemia_Homo sapiens_hsa052200.64641220
72Colorectal cancer_Homo sapiens_hsa052100.64021882
73Hematopoietic cell lineage_Homo sapiens_hsa046400.63264079
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63200093
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63077285
76Endometrial cancer_Homo sapiens_hsa052130.62561087
77Apoptosis_Homo sapiens_hsa042100.62248434
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.61908285
79Pentose phosphate pathway_Homo sapiens_hsa000300.61842760
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61564887
81Legionellosis_Homo sapiens_hsa051340.61473486
82HIF-1 signaling pathway_Homo sapiens_hsa040660.60851928
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60542149
84Choline metabolism in cancer_Homo sapiens_hsa052310.58470190
85Tuberculosis_Homo sapiens_hsa051520.58159249
86Notch signaling pathway_Homo sapiens_hsa043300.56577262
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56122387
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55078098
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53261925
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.51997305
91mTOR signaling pathway_Homo sapiens_hsa041500.51826401
92Insulin signaling pathway_Homo sapiens_hsa049100.51010284
93Basal cell carcinoma_Homo sapiens_hsa052170.49674206
94Allograft rejection_Homo sapiens_hsa053300.48828751
95Toxoplasmosis_Homo sapiens_hsa051450.47833536
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47758457
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46778231
98Leishmaniasis_Homo sapiens_hsa051400.46390067
99Pathways in cancer_Homo sapiens_hsa052000.46221135
100Insulin resistance_Homo sapiens_hsa049310.45611320
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45471858
102Non-small cell lung cancer_Homo sapiens_hsa052230.44733211
103Prolactin signaling pathway_Homo sapiens_hsa049170.43463285
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42894695
105Acute myeloid leukemia_Homo sapiens_hsa052210.41811733
106T cell receptor signaling pathway_Homo sapiens_hsa046600.39368950
107Viral myocarditis_Homo sapiens_hsa054160.39280449
108Circadian rhythm_Homo sapiens_hsa047100.39160065
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38788307
110Graft-versus-host disease_Homo sapiens_hsa053320.38055073
111TNF signaling pathway_Homo sapiens_hsa046680.37798767
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.35703685
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34317167
114Melanoma_Homo sapiens_hsa052180.33639539
115Proteasome_Homo sapiens_hsa030500.32639004
116Proteoglycans in cancer_Homo sapiens_hsa052050.31238168
117Hepatitis C_Homo sapiens_hsa051600.30409072
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28102267
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28050660
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.25910916
121Bladder cancer_Homo sapiens_hsa052190.24014967
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23856734
123Wnt signaling pathway_Homo sapiens_hsa043100.23494540
124Biosynthesis of amino acids_Homo sapiens_hsa012300.22973175
125Autoimmune thyroid disease_Homo sapiens_hsa053200.22968652
126Arachidonic acid metabolism_Homo sapiens_hsa005900.22921914
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22755370
128Tight junction_Homo sapiens_hsa045300.22277704

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