WARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.03859715
2doxorubicin metabolic process (GO:0044598)9.03859715
3daunorubicin metabolic process (GO:0044597)9.03859715
4protein localization to kinetochore (GO:0034501)6.25025219
5negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.74051517
6regulation of mammary gland epithelial cell proliferation (GO:0033599)5.65942763
7maintenance of protein location in nucleus (GO:0051457)5.63604242
8negative regulation of telomerase activity (GO:0051974)5.62247921
9aminoglycoside antibiotic metabolic process (GO:0030647)5.59030105
10somite rostral/caudal axis specification (GO:0032525)5.57226563
11negative regulation of epidermis development (GO:0045683)5.56875623
12negative regulation of cell cycle G2/M phase transition (GO:1902750)5.20127539
13histone H4-K8 acetylation (GO:0043982)5.13052965
14histone H4-K5 acetylation (GO:0043981)5.13052965
15regulation of telomere maintenance via telomerase (GO:0032210)5.11188024
16histone H4-K12 acetylation (GO:0043983)5.07143862
17cellular response to type I interferon (GO:0071357)5.05097260
18type I interferon signaling pathway (GO:0060337)5.05097260
19response to type I interferon (GO:0034340)4.98205516
20regulation of nuclear cell cycle DNA replication (GO:0033262)4.96961291
21muscle organ morphogenesis (GO:0048644)4.94003907
22regulation of response to osmotic stress (GO:0047484)4.93771404
23rRNA transcription (GO:0009303)4.92658388
24regulation of translation in response to stress (GO:0043555)4.83712843
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.72637085
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.68385340
27heterochromatin organization (GO:0070828)4.64930793
28negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.59993856
29intestinal epithelial cell development (GO:0060576)4.59487363
30positive regulation of gamma-delta T cell activation (GO:0046645)4.58138197
31mitotic sister chromatid segregation (GO:0000070)4.46301521
32regulation of MHC class I biosynthetic process (GO:0045343)4.43576239
33negative regulation of epidermal cell differentiation (GO:0045605)4.41664765
34protein localization to chromosome, centromeric region (GO:0071459)4.40857903
35GDP-mannose metabolic process (GO:0019673)4.40134475
36antigen processing and presentation of endogenous antigen (GO:0019883)4.38804514
37DNA replication-dependent nucleosome organization (GO:0034723)4.37618137
38DNA replication-dependent nucleosome assembly (GO:0006335)4.37618137
39maintenance of protein localization in organelle (GO:0072595)4.31619101
40intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)4.28914456
41interferon-gamma-mediated signaling pathway (GO:0060333)4.19092589
42macrophage activation involved in immune response (GO:0002281)4.13069858
43regulation of T-helper 1 cell differentiation (GO:0045625)4.11220770
44cullin deneddylation (GO:0010388)4.10823225
45hormone catabolic process (GO:0042447)4.09686215
46cytidine metabolic process (GO:0046087)4.01929825
47cytidine catabolic process (GO:0006216)4.01929825
48cytidine deamination (GO:0009972)4.01929825
49myeloid dendritic cell differentiation (GO:0043011)4.01417337
50negative regulation of interleukin-12 production (GO:0032695)3.97326153
51notochord development (GO:0030903)3.96286456
52immunoglobulin mediated immune response (GO:0016064)3.94145386
53formation of translation preinitiation complex (GO:0001731)3.92832380
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.92407912
55modulation by symbiont of host immune response (GO:0052553)3.91300655
56positive regulation by symbiont of host defense response (GO:0052509)3.91300655
57modulation by symbiont of host defense response (GO:0052031)3.91300655
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.91300655
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.91300655
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.91300655
61negative regulation of telomere maintenance (GO:0032205)3.91099048
62regulation of apoptotic process involved in morphogenesis (GO:1902337)3.90863163
63chromatin assembly (GO:0031497)3.88326186
64branching involved in mammary gland duct morphogenesis (GO:0060444)3.80750527
65sister chromatid segregation (GO:0000819)3.79375546
66maternal placenta development (GO:0001893)3.74568427
67response to interferon-beta (GO:0035456)3.74474868
68nuclear pore complex assembly (GO:0051292)3.74272431
69histone H4-K16 acetylation (GO:0043984)3.74196199
70DNA replication checkpoint (GO:0000076)3.74026418
71regulation of interferon-alpha production (GO:0032647)3.73711648
72lipopolysaccharide-mediated signaling pathway (GO:0031663)3.71514913
73detection of molecule of bacterial origin (GO:0032490)3.70899196
74regulation of T cell tolerance induction (GO:0002664)3.69012354
75protein deneddylation (GO:0000338)3.66976982
76regulation of dendritic cell antigen processing and presentation (GO:0002604)3.66699335
77pre-miRNA processing (GO:0031054)3.66036680
78positive regulation of DNA-dependent DNA replication (GO:2000105)3.65987031
79NIK/NF-kappaB signaling (GO:0038061)3.64862898
80regulation of vitamin D biosynthetic process (GO:0060556)3.60750362
81response to peptidoglycan (GO:0032494)3.60514212
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59412527
83primitive streak formation (GO:0090009)3.58617384
84regulation of telomerase activity (GO:0051972)3.58406043
85positive regulation of type 2 immune response (GO:0002830)3.57747029
86myeloid dendritic cell activation (GO:0001773)3.57130004
87positive regulation of interferon-alpha production (GO:0032727)3.56450141
88intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.55057119
89regulation of interleukin-2 biosynthetic process (GO:0045076)3.54405697
90pyrimidine ribonucleoside catabolic process (GO:0046133)3.54153927
91mitochondrion distribution (GO:0048311)3.53932119
92response to interferon-alpha (GO:0035455)3.53044408
93negative regulation of viral genome replication (GO:0045071)3.51625775
94rRNA modification (GO:0000154)3.47321909
95regulation of type I interferon-mediated signaling pathway (GO:0060338)3.46958927
96positive regulation of protein deacetylation (GO:0090312)3.46448850
97rRNA methylation (GO:0031167)3.46435529
98nucleoside transmembrane transport (GO:1901642)3.45012448
99cellular response to interferon-gamma (GO:0071346)3.44120589
100regulation of chronic inflammatory response (GO:0002676)3.43817526
101nuclear pore organization (GO:0006999)3.43258192
102regulation of posttranscriptional gene silencing (GO:0060147)3.42069583
103regulation of gene silencing by miRNA (GO:0060964)3.42069583
104regulation of gene silencing by RNA (GO:0060966)3.42069583
105B cell mediated immunity (GO:0019724)3.41940321
106regulation of cilium movement (GO:0003352)3.39034106
107regulation of interferon-beta biosynthetic process (GO:0045357)3.34434507
108response to interferon-gamma (GO:0034341)3.34273105
109response to dietary excess (GO:0002021)3.32726759
110T cell migration (GO:0072678)3.31000164
111negative regulation of cell killing (GO:0031342)3.29898029
112negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.29898029
113detection of other organism (GO:0098543)3.29384019
114regulation of hippo signaling (GO:0035330)3.27336458
115negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.26849946
116ribosome biogenesis (GO:0042254)3.26150753
117mRNA stabilization (GO:0048255)3.26025766
118RNA stabilization (GO:0043489)3.26025766
119regulation of response to interferon-gamma (GO:0060330)3.25578207
120cellular response to interferon-alpha (GO:0035457)3.23793555
121phenol-containing compound catabolic process (GO:0019336)3.23631407
122trophectodermal cell differentiation (GO:0001829)3.23041498
123retinoic acid receptor signaling pathway (GO:0048384)3.23037441
124positive regulation of histone deacetylation (GO:0031065)3.21922750
125detection of external biotic stimulus (GO:0098581)3.21625631
126vitamin A metabolic process (GO:0006776)3.20995081
127DNA duplex unwinding (GO:0032508)3.20589930
128regulation of tolerance induction (GO:0002643)3.20289866
129T-helper 1 type immune response (GO:0042088)3.20214266
130cellular response to interferon-beta (GO:0035458)3.20207699
131regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.19365566
132cellular modified amino acid catabolic process (GO:0042219)3.19246691
133epithelial cell differentiation involved in prostate gland development (GO:0060742)3.17833605
134cell fate commitment involved in formation of primary germ layer (GO:0060795)3.17819420
135regulation of gamma-delta T cell activation (GO:0046643)3.16914149
136DNA geometric change (GO:0032392)3.15507229
137interferon-gamma production (GO:0032609)3.14996343
138positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.14760466
139regulation of antigen processing and presentation (GO:0002577)3.13453555
140dendritic cell differentiation (GO:0097028)3.13253057
141DNA unwinding involved in DNA replication (GO:0006268)3.13146356
142regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.11351864
143detection of bacterium (GO:0016045)3.09633903
144cardiovascular system development (GO:0072358)3.08981905
145defense response to protozoan (GO:0042832)3.08011766
146regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.07181393
147positive regulation of antigen processing and presentation (GO:0002579)3.06027279
148proline transport (GO:0015824)3.05886205
149positive regulation of natural killer cell differentiation (GO:0032825)3.05677570
150folic acid-containing compound biosynthetic process (GO:0009396)3.05041415
151hypotonic response (GO:0006971)3.04594698
152pteridine-containing compound biosynthetic process (GO:0042559)3.02571381
153JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.99395334
154quinone metabolic process (GO:1901661)2.98776782
155arachidonic acid secretion (GO:0050482)2.98155104
156icosanoid secretion (GO:0032309)2.98155104
157histone arginine methylation (GO:0034969)2.96521114
158regulation of telomere maintenance (GO:0032204)2.96126396
159apoptotic DNA fragmentation (GO:0006309)2.96105487
160NLS-bearing protein import into nucleus (GO:0006607)2.95266976
161defense response to virus (GO:0051607)2.95191493
162positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94530538
163response to protozoan (GO:0001562)2.94289010
164Golgi transport vesicle coating (GO:0048200)2.93133502
165COPI coating of Golgi vesicle (GO:0048205)2.93133502
166regulation of interleukin-12 production (GO:0032655)2.92965703
167regulation of vitamin metabolic process (GO:0030656)2.91154966
168positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.90896031
169pseudouridine synthesis (GO:0001522)2.90453899
170positive regulation of tolerance induction (GO:0002645)2.88069991
171neutrophil activation involved in immune response (GO:0002283)2.85663889
172germinal center formation (GO:0002467)2.84613920
173response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.84410390
174response to host immune response (GO:0052572)2.84410390
175lymphocyte chemotaxis (GO:0048247)2.84145021
176regulation of interleukin-8 biosynthetic process (GO:0045414)2.83868470
177detection of biotic stimulus (GO:0009595)2.81568395
178positive regulation of toll-like receptor signaling pathway (GO:0034123)2.79191019
179regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.78219126
180regulation of type 2 immune response (GO:0002828)2.78159621
181negative regulation of T cell mediated immunity (GO:0002710)2.77717507
182positive regulation of interferon-beta production (GO:0032728)2.76134624
183regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.75008471
184negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.74879392
185production of molecular mediator involved in inflammatory response (GO:0002532)2.74673569
186myeloid cell activation involved in immune response (GO:0002275)2.74002811
187regulation of podosome assembly (GO:0071801)2.69146239
188positive regulation of defense response to virus by host (GO:0002230)2.68032117
189antigen processing and presentation via MHC class Ib (GO:0002475)2.67650146
190positive regulation of interleukin-10 production (GO:0032733)2.67332562
191positive regulation of interleukin-12 production (GO:0032735)2.65513723
192response to interleukin-15 (GO:0070672)2.64638748
193response to host (GO:0075136)2.64604868
194response to host defenses (GO:0052200)2.64604868
195response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64604868
196regulation of T-helper cell differentiation (GO:0045622)2.64343054
197regulation of regulatory T cell differentiation (GO:0045589)2.63603632
198negative regulation of cytokine production involved in immune response (GO:0002719)2.61567691
199positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.60537712
200positive regulation of cytokine biosynthetic process (GO:0042108)2.60103135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.16800766
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.11132411
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.11132411
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.11132411
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.30090468
6E2F7_22180533_ChIP-Seq_HELA_Human4.27008810
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.21033413
8BP1_19119308_ChIP-ChIP_Hs578T_Human4.19009304
9IRF8_21731497_ChIP-ChIP_J774_Mouse4.17212930
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.65465632
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.52614706
12* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.96561371
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.94856053
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.88968390
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.88905049
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.72719736
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.72238485
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58537106
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.57207776
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55690167
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.52243184
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51929620
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48991606
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46468522
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44262606
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.41846394
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40257579
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39649046
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.35042931
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.31966371
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.19916822
32MYC_18555785_ChIP-Seq_MESCs_Mouse2.18987139
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.06926345
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03857620
35TCF3_18692474_ChIP-Seq_MEFs_Mouse2.00346141
36SPI1_23547873_ChIP-Seq_NB4_Human1.97905075
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97588163
38MYC_22102868_ChIP-Seq_BL_Human1.97157532
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95987924
40MAF_26560356_Chip-Seq_TH1_Human1.90214911
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.89611961
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.88559840
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.88173201
44MYB_26560356_Chip-Seq_TH2_Human1.87988020
45GATA1_22025678_ChIP-Seq_K562_Human1.87980508
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.86279298
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.80418890
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.74891069
49VDR_21846776_ChIP-Seq_THP-1_Human1.73224870
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.72058943
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70249915
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70188911
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69570410
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68039184
55NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.67996282
56NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.67922227
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67041435
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65651955
59MYB_26560356_Chip-Seq_TH1_Human1.65132780
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64411101
61* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63984321
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60310287
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56343643
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53029333
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52054587
66SPI1_23127762_ChIP-Seq_K562_Human1.51081032
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.50909966
68VDR_24763502_ChIP-Seq_THP-1_Human1.50592767
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45247299
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43526306
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.42381193
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42063548
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39850005
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35402985
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35106923
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.34325966
77MAF_26560356_Chip-Seq_TH2_Human1.33723519
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33636409
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32438509
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31561083
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.31103836
82OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30153841
83UTX_26944678_Chip-Seq_JUKART_Human1.29746695
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29671960
85POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28732702
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27145501
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26018574
88TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.25928367
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24652356
90RUNX_20019798_ChIP-Seq_JUKART_Human1.24211006
91NANOG_18692474_ChIP-Seq_MEFs_Mouse1.23160816
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23022165
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20292706
94POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20283879
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19543442
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19193987
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17359613
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17251274
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16800262
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16024893
101NANOG_18692474_ChIP-Seq_MESCs_Mouse1.15827931
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.15809565
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14627392
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14258697
105EST1_17652178_ChIP-ChIP_JURKAT_Human1.14256552
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14121155
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14015141
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.13904105
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13252602
110SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12788349
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11931703
112ETS1_20019798_ChIP-Seq_JURKAT_Human1.11833304
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11674927
114GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10556004
115SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10326569
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09965032
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09210383
118E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08943066
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08632323
120TP53_22127205_ChIP-Seq_IMR90_Human1.08261021
121* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07741964
122SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07354984
123IRF1_19129219_ChIP-ChIP_H3396_Human1.07329392
124KDM5A_27292631_Chip-Seq_BREAST_Human1.07320389
125XRN2_22483619_ChIP-Seq_HELA_Human1.07213915
126NCOR1_26117541_ChIP-Seq_K562_Human1.06953425
127* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.06716986
128PU_27001747_Chip-Seq_BMDM_Mouse1.06639271
129RACK7_27058665_Chip-Seq_MCF-7_Human1.05953515
130CLOCK_20551151_ChIP-Seq_293T_Human1.04071677
131KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02565757
132VDR_24787735_ChIP-Seq_THP-1_Human1.01752177
133GATA3_27048872_Chip-Seq_THYMUS_Human1.01664217
134PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01517960
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01464643
136CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00856275
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00412514
138CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00126824
139ELF1_20517297_ChIP-Seq_JURKAT_Human1.00089784
140TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00012564
141TCF7_22412390_ChIP-Seq_EML_Mouse0.99587085
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.99058603
143* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98763508
144KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98620694
145TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98496856
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96289351
147SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95953639
148* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95938356
149TFEB_21752829_ChIP-Seq_HELA_Human0.95854289
150ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94840177
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92790286
152* GABP_19822575_ChIP-Seq_HepG2_Human0.92684273
153* LXR_22292898_ChIP-Seq_THP-1_Human0.92098359
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.92080350
155NANOG_16518401_ChIP-PET_MESCs_Mouse0.91861693
156FOXP3_21729870_ChIP-Seq_TREG_Human0.91795077
157* ATF3_27146783_Chip-Seq_COLON_Human0.91769408
158SCL_19346495_ChIP-Seq_HPC-7_Human0.91515498
159KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91429515
160CIITA_25753668_ChIP-Seq_RAJI_Human0.91410435
161SMC4_20622854_ChIP-Seq_HELA_Human0.91289281
162* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91272837
163CDX2_20551321_ChIP-Seq_CACO-2_Human0.90756269
164TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90721642
165* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90472231
166KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90093949
167* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89904858
168PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89884630
169P68_20966046_ChIP-Seq_HELA_Human0.89545042
170VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88820687
171GATA1_19941827_ChIP-Seq_MEL_Mouse0.88060796
172TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87963180
173HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87503346
174* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87234664
175KDM2B_26808549_Chip-Seq_DND41_Human0.86982884
176ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86735117
177KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86562709
178AR_21909140_ChIP-Seq_LNCAP_Human0.86174109
179MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85284916
180GATA3_26560356_Chip-Seq_TH2_Human0.85172664
181EGR1_19032775_ChIP-ChIP_M12_Human0.84495228
182PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82383563
183RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82252486
184CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82084875
185DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80754768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.79520537
2MP0001835_abnormal_antigen_presentation4.30064994
3MP0004858_abnormal_nervous_system3.91779155
4MP0003303_peritoneal_inflammation3.89741170
5MP0002254_reproductive_system_inflammat3.59326357
6MP0003890_abnormal_embryonic-extraembry3.41288219
7MP0003724_increased_susceptibility_to3.34131585
8MP0009785_altered_susceptibility_to3.31784148
9MP0003705_abnormal_hypodermis_morpholog3.29546931
10MP0004957_abnormal_blastocyst_morpholog3.26851666
11MP0001790_abnormal_immune_system3.22563140
12MP0005387_immune_system_phenotype3.22563140
13MP0003122_maternal_imprinting3.16748615
14MP0003011_delayed_dark_adaptation3.11581571
15MP0003436_decreased_susceptibility_to3.09186019
16MP0005671_abnormal_response_to3.06901226
17MP0002148_abnormal_hypersensitivity_rea3.06636014
18MP0010352_gastrointestinal_tract_polyps3.03349157
19MP0000685_abnormal_immune_system2.86714629
20MP0005000_abnormal_immune_tolerance2.82408659
21MP0006292_abnormal_olfactory_placode2.80385136
22MP0005025_abnormal_response_to2.69444784
23MP0005394_taste/olfaction_phenotype2.66843910
24MP0005499_abnormal_olfactory_system2.66843910
25MP0001800_abnormal_humoral_immune2.60599131
26MP0003300_gastrointestinal_ulcer2.58817217
27MP0002332_abnormal_exercise_endurance2.41856944
28MP0002452_abnormal_antigen_presenting2.37279651
29MP0002723_abnormal_immune_serum2.37092743
30MP0002419_abnormal_innate_immunity2.36216437
31MP0005451_abnormal_body_composition2.31398018
32MP0003183_abnormal_peptide_metabolism2.30146656
33MP0005075_abnormal_melanosome_morpholog2.27979994
34MP0002653_abnormal_ependyma_morphology2.27965004
35MP0003123_paternal_imprinting2.26351001
36MP0003121_genomic_imprinting2.25201631
37MP0008961_abnormal_basal_metabolism2.14327904
38MP0008057_abnormal_DNA_replication2.10158526
39MP0005058_abnormal_lysosome_morphology2.08618838
40MP0010155_abnormal_intestine_physiology2.07849242
41MP0005257_abnormal_intraocular_pressure2.05702390
42MP0009333_abnormal_splenocyte_physiolog2.05692611
43MP0001819_abnormal_immune_cell2.05574497
44MP0002420_abnormal_adaptive_immunity2.05050162
45MP0000678_abnormal_parathyroid_gland2.00762404
46MP0006035_abnormal_mitochondrial_morpho2.00516881
47MP0001672_abnormal_embryogenesis/_devel1.97922087
48MP0005380_embryogenesis_phenotype1.97922087
49MP0004947_skin_inflammation1.93054939
50MP0002088_abnormal_embryonic_growth/wei1.91699930
51MP0003984_embryonic_growth_retardation1.90857024
52MP0001845_abnormal_inflammatory_respons1.88181555
53MP0003283_abnormal_digestive_organ1.81956573
54MP0003763_abnormal_thymus_physiology1.80704701
55MP0004510_myositis1.74830445
56MP0001849_ear_inflammation1.73405473
57MP0001533_abnormal_skeleton_physiology1.72309585
58MP0000350_abnormal_cell_proliferation1.72085730
59MP0002277_abnormal_respiratory_mucosa1.67192186
60MP0002405_respiratory_system_inflammati1.63986794
61MP0008260_abnormal_autophagy1.59869386
62MP0001853_heart_inflammation1.58420076
63MP0003077_abnormal_cell_cycle1.58306319
64MP0002398_abnormal_bone_marrow1.57242131
65MP0000716_abnormal_immune_system1.57209920
66MP0002166_altered_tumor_susceptibility1.51829449
67MP0008469_abnormal_protein_level1.51403901
68MP0002086_abnormal_extraembryonic_tissu1.48308344
69MP0001873_stomach_inflammation1.47813174
70MP0009764_decreased_sensitivity_to1.46596442
71MP0003806_abnormal_nucleotide_metabolis1.46110550
72MP0004043_abnormal_pH_regulation1.44270333
73MP0003075_altered_response_to1.42645025
74MP0002396_abnormal_hematopoietic_system1.42135348
75MP0002085_abnormal_embryonic_tissue1.40941771
76MP0000343_altered_response_to1.40547330
77MP0003191_abnormal_cellular_cholesterol1.40437908
78MP0010030_abnormal_orbit_morphology1.39081093
79MP0001348_abnormal_lacrimal_gland1.35738354
80MP0002084_abnormal_developmental_patter1.35259290
81MP0000490_abnormal_crypts_of1.34851778
82MP0002127_abnormal_cardiovascular_syste1.34378965
83MP0001730_embryonic_growth_arrest1.34150579
84MP0005166_decreased_susceptibility_to1.33277888
85MP0003111_abnormal_nucleus_morphology1.32814235
86MP0002429_abnormal_blood_cell1.32474172
87MP0009840_abnormal_foam_cell1.31665641
88MP0005464_abnormal_platelet_physiology1.31407171
89MP0002006_tumorigenesis1.29789272
90MP0000604_amyloidosis1.27258158
91MP0003119_abnormal_digestive_system1.26269410
92MP0002722_abnormal_immune_system1.26161996
93MP0000689_abnormal_spleen_morphology1.24163409
94MP0001293_anophthalmia1.24133398
95MP0002932_abnormal_joint_morphology1.19655141
96MP0000750_abnormal_muscle_regeneration1.18461730
97MP0001697_abnormal_embryo_size1.16238739
98MP0002080_prenatal_lethality1.15769417
99MP0003938_abnormal_ear_development1.15414099
100MP0003453_abnormal_keratinocyte_physiol1.12965577
101MP0004197_abnormal_fetal_growth/weight/1.11491016
102MP0005310_abnormal_salivary_gland1.11291982
103MP0001545_abnormal_hematopoietic_system1.11164248
104MP0005397_hematopoietic_system_phenotyp1.11164248
105MP0003656_abnormal_erythrocyte_physiolo1.10911108
106MP0003091_abnormal_cell_migration1.09082998
107MP0000428_abnormal_craniofacial_morphol1.09028934
108MP0002998_abnormal_bone_remodeling1.08656685
109MP0003866_abnormal_defecation1.08173409
110MP0003693_abnormal_embryo_hatching1.08150917
111MP0005266_abnormal_metabolism1.07830780
112MP0002909_abnormal_adrenal_gland1.05831622
113MP0002092_abnormal_eye_morphology1.04622333
114MP0008438_abnormal_cutaneous_collagen1.04583423
115MP0004133_heterotaxia1.03914134
116MP0008004_abnormal_stomach_pH1.03203877
117MP0003315_abnormal_perineum_morphology1.02963152
118MP0000358_abnormal_cell_content/1.02936316
119MP0000313_abnormal_cell_death1.02489271
120MP0009278_abnormal_bone_marrow1.02254867
121MP0008770_decreased_survivor_rate1.00602637
122MP0009763_increased_sensitivity_to1.00002676
123MP0005023_abnormal_wound_healing0.96639509
124MP0006082_CNS_inflammation0.95703695
125MP0005164_abnormal_response_to0.94978957
126MP0002114_abnormal_axial_skeleton0.94160284
127MP0002970_abnormal_white_adipose0.94027970
128MP0000703_abnormal_thymus_morphology0.93195582
129MP0003045_fibrosis0.93119687
130MP0002138_abnormal_hepatobiliary_system0.91632038
131MP0002269_muscular_atrophy0.91477856
132MP0008932_abnormal_embryonic_tissue0.91268648
133MP0010094_abnormal_chromosome_stability0.90939545
134MP0002925_abnormal_cardiovascular_devel0.90127756
135MP0003950_abnormal_plasma_membrane0.87139869
136MP0005623_abnormal_meninges_morphology0.86974114
137MP0004808_abnormal_hematopoietic_stem0.86835522
138MP0003828_pulmonary_edema0.85999799
139MP0003172_abnormal_lysosome_physiology0.85512102
140MP0008789_abnormal_olfactory_epithelium0.84173467
141MP0005384_cellular_phenotype0.83838768
142MP0000858_altered_metastatic_potential0.81009813
143MP0003566_abnormal_cell_adhesion0.80849901
144MP0005165_increased_susceptibility_to0.79388397
145MP0003137_abnormal_impulse_conducting0.77950328
146MP0000537_abnormal_urethra_morphology0.77921333
147MP0000465_gastrointestinal_hemorrhage0.77714676
148MP0000762_abnormal_tongue_morphology0.77680506
149MP0000049_abnormal_middle_ear0.77476577
150MP0008007_abnormal_cellular_replicative0.77211087
151MP0003935_abnormal_craniofacial_develop0.76791965
152MP0006054_spinal_hemorrhage0.75994468
153MP0002233_abnormal_nose_morphology0.75746451
154MP0003221_abnormal_cardiomyocyte_apopto0.75141886
155MP0009765_abnormal_xenobiotic_induced0.74673938
156MP0002933_joint_inflammation0.74622530
157MP0000432_abnormal_head_morphology0.74549101
158MP0005390_skeleton_phenotype0.72954180
159MP0000749_muscle_degeneration0.72466017
160MP0004883_abnormal_blood_vessel0.71687589
161MP0010234_abnormal_vibrissa_follicle0.69402915
162MP0000371_diluted_coat_color0.69331905
163MP0002877_abnormal_melanocyte_morpholog0.68932374
164MP0009703_decreased_birth_body0.68050933
165MP0001663_abnormal_digestive_system0.68041404
166MP0005248_abnormal_Harderian_gland0.66810487
167MP0001542_abnormal_bone_strength0.65898595
168MP0002019_abnormal_tumor_incidence0.65617237
169MP0003795_abnormal_bone_structure0.65260816
170MP0005621_abnormal_cell_physiology0.64718132
171MP0003787_abnormal_imprinting0.64127239
172MP0002111_abnormal_tail_morphology0.63419537
173MP0003942_abnormal_urinary_system0.63175728
174MP0003329_amyloid_beta_deposits0.62458719
175MP0003186_abnormal_redox_activity0.61542775
176MP0000609_abnormal_liver_physiology0.60135099
177MP0005508_abnormal_skeleton_morphology0.60051622
178MP0001851_eye_inflammation0.59939324
179MP0004272_abnormal_basement_membrane0.59632836
180MP0002132_abnormal_respiratory_system0.59628909
181MP0004782_abnormal_surfactant_physiolog0.59201485
182MP0003448_altered_tumor_morphology0.57690980
183MP0005076_abnormal_cell_differentiation0.55931868

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.85460007
2Multiple enchondromatosis (HP:0005701)5.39695042
3Hepatoblastoma (HP:0002884)4.97933378
4Retrobulbar optic neuritis (HP:0100654)4.85093273
5Optic neuritis (HP:0100653)4.85093273
6Abnormality of the lower motor neuron (HP:0002366)4.81080943
7Orchitis (HP:0100796)4.79775663
8Ependymoma (HP:0002888)4.67602347
9Hypochromic microcytic anemia (HP:0004840)4.39052986
10Myositis (HP:0100614)4.33044586
11Abnormality of macrophages (HP:0004311)4.32168476
12Eczematoid dermatitis (HP:0000976)4.14518038
13Recurrent bacterial skin infections (HP:0005406)4.10326035
14Rib fusion (HP:0000902)3.90078796
15Testicular atrophy (HP:0000029)3.89598049
16Recurrent cutaneous fungal infections (HP:0011370)3.82979463
17Chronic mucocutaneous candidiasis (HP:0002728)3.82979463
18Recurrent abscess formation (HP:0002722)3.81857640
19Increased IgM level (HP:0003496)3.80521948
20Recurrent fungal infections (HP:0002841)3.63410889
21Recurrent viral infections (HP:0004429)3.62109592
22Trismus (HP:0000211)3.61513179
23Neoplasm of striated muscle (HP:0009728)3.48382282
24Vasculitis (HP:0002633)3.44501015
25Pulmonary infiltrates (HP:0002113)3.42500858
26Hemoptysis (HP:0002105)3.40522964
27Keratoconjunctivitis sicca (HP:0001097)3.36895372
28Systemic lupus erythematosus (HP:0002725)3.35804323
29Mediastinal lymphadenopathy (HP:0100721)3.30746976
30Abnormality of the astrocytes (HP:0100707)3.30362230
31Astrocytoma (HP:0009592)3.30362230
32Rhabdomyosarcoma (HP:0002859)3.29521040
33Recurrent skin infections (HP:0001581)3.24477596
34Fused cervical vertebrae (HP:0002949)3.19676745
35Abnormality of T cell number (HP:0011839)3.17727706
36Hand muscle atrophy (HP:0009130)3.17288576
37Abnormality of the salivary glands (HP:0010286)3.11141166
38Amyotrophic lateral sclerosis (HP:0007354)3.10494559
39T lymphocytopenia (HP:0005403)3.05267304
40Keratoconjunctivitis (HP:0001096)3.04047386
41Abnormal delayed hypersensitivity skin test (HP:0002963)3.03247070
42Gastrointestinal infarctions (HP:0005244)3.01273369
43Autoimmune hemolytic anemia (HP:0001890)3.00562898
44Aplasia/hypoplasia of the humerus (HP:0006507)2.99613336
45Short humerus (HP:0005792)2.99538556
46Elevated erythrocyte sedimentation rate (HP:0003565)2.97012106
47Ragged-red muscle fibers (HP:0003200)2.95650146
48Stomatitis (HP:0010280)2.94044186
49Shawl scrotum (HP:0000049)2.92821270
50Meningitis (HP:0001287)2.90687057
51Loss of speech (HP:0002371)2.86979094
52Hyperinsulinemic hypoglycemia (HP:0000825)2.86943390
53Autoimmune thrombocytopenia (HP:0001973)2.86750672
54Nephroblastoma (Wilms tumor) (HP:0002667)2.84304385
55Neoplasm of the heart (HP:0100544)2.82678368
56Progressive muscle weakness (HP:0003323)2.82060832
57IgA deficiency (HP:0002720)2.79517989
58Arterial thrombosis (HP:0004420)2.78909604
59Hypergammaglobulinemia (HP:0010702)2.75352744
60Gastrointestinal stroma tumor (HP:0100723)2.74200103
61Interstitial pulmonary disease (HP:0006530)2.71997680
62Recurrent bronchitis (HP:0002837)2.71933932
63Recurrent gram-negative bacterial infections (HP:0005420)2.70666662
64Chronic diarrhea (HP:0002028)2.70382758
65Generalized hypotonia (HP:0001290)2.66710456
66Embryonal renal neoplasm (HP:0011794)2.65889354
67Abnormal cartilage morphology (HP:0002763)2.64416248
68Chronic otitis media (HP:0000389)2.63398529
69Encephalitis (HP:0002383)2.63266605
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.60424369
71Hypoplasia of the fovea (HP:0007750)2.60424369
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59582376
73Urticaria (HP:0001025)2.57931703
74Resting tremor (HP:0002322)2.57072840
75Chronic obstructive pulmonary disease (HP:0006510)2.56921650
76Obstructive lung disease (HP:0006536)2.56921650
77Renal duplication (HP:0000075)2.56096157
78Horizontal nystagmus (HP:0000666)2.55005283
79Preauricular skin tag (HP:0000384)2.55001974
80Upper limb amyotrophy (HP:0009129)2.54440918
81Distal upper limb amyotrophy (HP:0007149)2.54440918
82Atrophy/Degeneration involving motor neurons (HP:0007373)2.53500877
83Abnormality of T cells (HP:0002843)2.51280476
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46980974
85Reduced antithrombin III activity (HP:0001976)2.46713853
86Gangrene (HP:0100758)2.44776745
87Gingivitis (HP:0000230)2.43503488
88Abnormality of cells of the lymphoid lineage (HP:0012140)2.41115942
89Abnormality of the musculature of the hand (HP:0001421)2.40813593
90Vacuolated lymphocytes (HP:0001922)2.40739085
91Adenoma sebaceum (HP:0009720)2.35765950
92Angiofibromas (HP:0010615)2.35765950
93Increased serum ferritin (HP:0003281)2.35298441
94Colitis (HP:0002583)2.33970243
95Glioma (HP:0009733)2.32191258
96Glossoptosis (HP:0000162)2.31181414
97Difficulty running (HP:0009046)2.30973562
98Skin tags (HP:0010609)2.30511397
99Anorexia (HP:0002039)2.30479625
100Myocardial infarction (HP:0001658)2.29920356
101Lymphopenia (HP:0001888)2.29256132
102Hypertensive crisis (HP:0100735)2.28372217
103Partial duplication of thumb phalanx (HP:0009944)2.27485575
104Abnormality of T cell physiology (HP:0011840)2.27010706
105Dysostosis multiplex (HP:0000943)2.26599863
106Increased cerebral lipofuscin (HP:0011813)2.26292885
107Rectovaginal fistula (HP:0000143)2.24902415
108Rectal fistula (HP:0100590)2.24902415
109Increased connective tissue (HP:0009025)2.24056217
110Nasal polyposis (HP:0100582)2.23102285
111Fatigue (HP:0012378)2.23060101
112Emphysema (HP:0002097)2.22961290
113Joint swelling (HP:0001386)2.20802772
114Villous atrophy (HP:0011473)2.20133106
115Abnormality of small intestinal villus morphology (HP:0011472)2.20133106
116Premature loss of primary teeth (HP:0006323)2.18577154
117Achilles tendon contracture (HP:0001771)2.18199066
118Microretrognathia (HP:0000308)2.15960451
119Fasciculations (HP:0002380)2.15856026
120Malignant neoplasm of the central nervous system (HP:0100836)2.14335037
121Amaurosis fugax (HP:0100576)2.13945972
122Cholecystitis (HP:0001082)2.13246841
123Abnormal gallbladder physiology (HP:0012438)2.13246841
124Tongue fasciculations (HP:0001308)2.13133751
125Restrictive lung disease (HP:0002091)2.12575638
126Chromsome breakage (HP:0040012)2.12493347
127Abnormality of the fovea (HP:0000493)2.12277083
128Abnormal lung lobation (HP:0002101)2.12251561
129Hepatosplenomegaly (HP:0001433)2.12124166
130Cheilitis (HP:0100825)2.11255341
131Spinal muscular atrophy (HP:0007269)2.10575410
132Aplastic anemia (HP:0001915)2.10372725
133Abnormality of the endocardium (HP:0004306)2.09822756
134Abnormality of liposaccharide metabolism (HP:0010968)2.08749632
135Abnormality of glycosphingolipid metabolism (HP:0004343)2.08749632
136Abnormality of glycolipid metabolism (HP:0010969)2.08749632
137Abnormality of the nasal mucosa (HP:0000433)2.07739153
138Mildly elevated creatine phosphokinase (HP:0008180)2.07178052
139Missing ribs (HP:0000921)2.07093294
140Abnormality of chromosome segregation (HP:0002916)2.06802064
141Leukocytosis (HP:0001974)2.06520046
142Chest pain (HP:0100749)2.05941700
143Bifid tongue (HP:0010297)2.05873277
144Muscle fibrillation (HP:0010546)2.04413506
145Cellulitis (HP:0100658)2.04297108
146Glomerulopathy (HP:0100820)2.04049728
147Granulocytopenia (HP:0001913)2.03947211
148Tetraplegia (HP:0002445)2.02374643
149Hypopigmentation of the fundus (HP:0007894)2.02273402
150Type I transferrin isoform profile (HP:0003642)2.02086955
151Abnormality of the pleura (HP:0002103)2.01777085
152Inflammation of the large intestine (HP:0002037)2.01371949
153Gastrointestinal inflammation (HP:0004386)2.01227281
154Polyneuropathy (HP:0001271)2.00852468
155Failure to thrive in infancy (HP:0001531)1.98654241
156Partial duplication of the phalanx of hand (HP:0009999)1.98529155
157Intestinal fistula (HP:0100819)1.97906240
158Hypoplastic scapulae (HP:0000882)1.97375859
159Aplasia/Hypoplasia of the scapulae (HP:0006713)1.97375859
160Increased IgE level (HP:0003212)1.97230748
161Keratitis (HP:0000491)1.96692846
162Osteomyelitis (HP:0002754)1.96503147
163Abnormality of the distal phalanx of the thumb (HP:0009617)1.96409730
164Glomerulonephritis (HP:0000099)1.94012881
165Pulmonary embolism (HP:0002204)1.93517761
166Abnormality of the intrinsic pathway (HP:0010989)1.92899650
167Hypochromic anemia (HP:0001931)1.92230184
168Skin rash (HP:0000988)1.92097209
169Short 5th finger (HP:0009237)1.91958926
170Vaginal fistula (HP:0004320)1.91801867
171Progressive neurologic deterioration (HP:0002344)1.90909489
172Arthralgia (HP:0002829)1.90732068
173Spontaneous hematomas (HP:0007420)1.89530300
174Upper limb muscle weakness (HP:0003484)1.89263558
175Preauricular pit (HP:0004467)1.88376270
176Periauricular skin pits (HP:0100277)1.88376270
177Malnutrition (HP:0004395)1.88175635
178IgG deficiency (HP:0004315)1.87730955
179Abnormality of the peritoneum (HP:0002585)1.87277074
180Skin ulcer (HP:0200042)1.86350113
181Petechiae (HP:0000967)1.85356758
182Meckel diverticulum (HP:0002245)1.85305005
183Micronodular cirrhosis (HP:0001413)1.85277571
184Abnormality of the motor neurons (HP:0002450)1.84295074
185Abnormal neuron morphology (HP:0012757)1.84295074
186Vertebral compression fractures (HP:0002953)1.84039054
187Webbed neck (HP:0000465)1.82422157
188Medulloblastoma (HP:0002885)1.81939945
189Vertebral fusion (HP:0002948)1.80180631
190Amblyopia (HP:0000646)1.79806772
191Premature ovarian failure (HP:0008209)1.78518665
192Sensory axonal neuropathy (HP:0003390)1.78007610

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.63431828
2ERN15.89551036
3GRK54.39670988
4TYK24.11644568
5RIPK43.73051599
6GRK63.68876849
7IRAK33.09788597
8MAP3K143.07297568
9MAP4K12.91054423
10PRPF4B2.90212700
11FGFR42.80113675
12JAK32.78504107
13TXK2.71205021
14CSF1R2.59133005
15JAK12.39697042
16TYRO32.39116471
17TTK2.37010478
18IKBKE2.36072529
19IRAK42.30464471
20TBK12.29529070
21STK102.23679151
22GRK12.17943937
23TGFBR22.10900968
24ADRBK22.07715386
25AKT32.06792655
26MATK2.01309638
27EPHA21.88680692
28MAP3K131.83079123
29BLK1.81555575
30PAK41.80558641
31MAPK71.75143608
32NTRK11.73076424
33MOS1.72476817
34BMPR21.71910715
35NME21.56604492
36TRIB31.55139632
37GRK71.53758732
38TAOK21.53049017
39WNK11.47554385
40KIT1.46176786
41JAK21.43254735
42IKBKB1.43172284
43ZAP701.39348703
44SMG11.36074695
45SIK31.34875950
46EPHB11.33982505
47CDK71.32337394
48PRKG21.31686736
49FGR1.28641442
50MAP3K101.28294770
51MAP2K31.11693848
52CAMK41.10985287
53SCYL21.10410154
54IRAK11.10232590
55RPS6KB21.09929509
56EEF2K1.09127016
57SYK1.07425527
58ALK1.06423654
59MAPKAPK31.06013470
60HIPK21.05300141
61CDC42BPA1.04533038
62EIF2AK11.03144404
63MARK21.02577410
64CLK11.00425124
65LYN0.99131704
66PLK10.97169207
67EPHA30.94602938
68KSR20.93436621
69NEK10.93035227
70LATS20.91899683
71MAP3K90.91580640
72CHEK20.90474061
73FGFR30.90150843
74MAP2K40.89957223
75BTK0.87375792
76MAP3K10.86139250
77HCK0.84959438
78MAP2K60.84506404
79FES0.84393435
80ADRBK10.83641345
81PIM20.82509043
82PRKCI0.82245875
83LCK0.79853084
84AKT20.79778433
85MTOR0.78898595
86IRAK20.78189088
87CHEK10.77172868
88BUB10.76054030
89RIPK10.75952624
90MST1R0.75613648
91MAPK110.71642700
92PDGFRA0.71302534
93CDC70.70977781
94CHUK0.68823478
95NEK90.68793280
96PTK20.68497906
97TESK20.67181998
98PKN20.64904420
99ARAF0.62700608
100MAP3K110.62170565
101PAK10.58878475
102MAP2K20.56152318
103MARK30.55667687
104LMTK20.55518715
105BMX0.53567892
106ITK0.52624356
107BCKDK0.52244168
108PAK20.50223428
109PDPK10.49777470
110TEC0.48814618
111AURKA0.48249203
112MAP3K50.47619853
113NEK20.46693536
114CDK20.45792302
115MAP3K120.45209776
116STK240.44909494
117TTN0.44846437
118MST40.44489508
119PRKD30.43682835
120PDK10.43503868
121MAP3K30.42795470
122MAPK120.42581091
123PASK0.42577991
124MAP3K70.42099080
125LRRK20.41660650
126CSK0.40413961
127PDK30.38519818
128PDK40.38519818
129MAP3K80.38457600
130NME10.38407463
131PRKCQ0.36182268
132FLT30.35609309
133AURKB0.34541579
134PIK3CG0.33188870
135EGFR0.32696763
136PDK20.31664150
137KSR10.30713262
138PIM10.30616834
139RAF10.29614282
140CSNK1E0.29432345
141KDR0.29314420
142TAOK10.29168801
143CDK150.29107092
144TESK10.27028879
145BRSK20.26539826
146PAK60.26480086
147TSSK60.26175790
148CDK11A0.25948871
149MAP3K20.25483032
150CDK180.25455976
151IGF1R0.23376551
152ICK0.21558998
153EIF2AK30.21486263
154CDK140.20977928
155SIK10.20752295
156DDR20.20327574
157WEE10.19302599
158CDK40.19118532
159PRKCD0.19027933
160BRSK10.18725185
161MAPKAPK20.17396017
162ATM0.16995734
163CDK10.16455866
164MAPK100.15983204

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.61334005
2Vitamin B6 metabolism_Homo sapiens_hsa007504.00346544
3Fructose and mannose metabolism_Homo sapiens_hsa000513.68498079
4Allograft rejection_Homo sapiens_hsa053303.49448711
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.49059250
6Autoimmune thyroid disease_Homo sapiens_hsa053203.13239559
7Graft-versus-host disease_Homo sapiens_hsa053323.00193648
8Asthma_Homo sapiens_hsa053102.91103830
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.73614048
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.66517340
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.61903030
12Leishmaniasis_Homo sapiens_hsa051402.60513722
13Type I diabetes mellitus_Homo sapiens_hsa049402.41043086
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.39287813
15Galactose metabolism_Homo sapiens_hsa000522.35921051
16Staphylococcus aureus infection_Homo sapiens_hsa051502.33778051
17Measles_Homo sapiens_hsa051622.20915647
18Osteoclast differentiation_Homo sapiens_hsa043802.16040001
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.03143204
20Rheumatoid arthritis_Homo sapiens_hsa053231.99725108
21Viral myocarditis_Homo sapiens_hsa054161.98844874
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.95829307
23RNA transport_Homo sapiens_hsa030131.92879248
24Thyroid cancer_Homo sapiens_hsa052161.91098546
25Tuberculosis_Homo sapiens_hsa051521.89560629
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.87338868
27mTOR signaling pathway_Homo sapiens_hsa041501.86834528
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81688048
29Arachidonic acid metabolism_Homo sapiens_hsa005901.80303883
30Primary immunodeficiency_Homo sapiens_hsa053401.80082536
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79510975
32* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77015090
33Toxoplasmosis_Homo sapiens_hsa051451.72417030
34TNF signaling pathway_Homo sapiens_hsa046681.62555949
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.54663091
36B cell receptor signaling pathway_Homo sapiens_hsa046621.53834175
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53787008
38One carbon pool by folate_Homo sapiens_hsa006701.53506210
39Hematopoietic cell lineage_Homo sapiens_hsa046401.47733407
40African trypanosomiasis_Homo sapiens_hsa051431.46800934
41DNA replication_Homo sapiens_hsa030301.46491277
42Other glycan degradation_Homo sapiens_hsa005111.46443731
43Pertussis_Homo sapiens_hsa051331.45620599
44Malaria_Homo sapiens_hsa051441.44528976
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37303571
46Hepatitis C_Homo sapiens_hsa051601.33595549
47Hepatitis B_Homo sapiens_hsa051611.32025225
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31277835
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29661509
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27122659
51Salmonella infection_Homo sapiens_hsa051321.25548997
52Phagosome_Homo sapiens_hsa041451.25514457
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24178146
54mRNA surveillance pathway_Homo sapiens_hsa030151.24145384
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.22333924
56Linoleic acid metabolism_Homo sapiens_hsa005911.19841642
57Mismatch repair_Homo sapiens_hsa034301.18056616
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.17585022
59Shigellosis_Homo sapiens_hsa051311.14688352
60T cell receptor signaling pathway_Homo sapiens_hsa046601.13883652
61Chemokine signaling pathway_Homo sapiens_hsa040621.13252430
62Cell cycle_Homo sapiens_hsa041101.10218210
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08898441
64Epstein-Barr virus infection_Homo sapiens_hsa051691.07279483
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06621630
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01208834
67Protein digestion and absorption_Homo sapiens_hsa049741.00651362
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00193587
69Bladder cancer_Homo sapiens_hsa052190.96136328
70Spliceosome_Homo sapiens_hsa030400.88655649
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87931046
72VEGF signaling pathway_Homo sapiens_hsa043700.87609913
73Inositol phosphate metabolism_Homo sapiens_hsa005620.85667336
74Hippo signaling pathway_Homo sapiens_hsa043900.85428920
75Acute myeloid leukemia_Homo sapiens_hsa052210.83584473
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83442472
77Biosynthesis of amino acids_Homo sapiens_hsa012300.81369153
78Ribosome_Homo sapiens_hsa030100.81211720
79Prion diseases_Homo sapiens_hsa050200.76562740
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75822505
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75378985
82Pathways in cancer_Homo sapiens_hsa052000.75039186
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74416038
84Pancreatic secretion_Homo sapiens_hsa049720.74124517
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.73976015
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73774671
87Non-small cell lung cancer_Homo sapiens_hsa052230.73536699
88Apoptosis_Homo sapiens_hsa042100.73521296
89Renin-angiotensin system_Homo sapiens_hsa046140.72612079
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72607548
91Base excision repair_Homo sapiens_hsa034100.72416495
92Pentose phosphate pathway_Homo sapiens_hsa000300.71982023
93Prolactin signaling pathway_Homo sapiens_hsa049170.71080831
94MicroRNAs in cancer_Homo sapiens_hsa052060.69987313
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.69764267
96Tight junction_Homo sapiens_hsa045300.68003385
97Carbon metabolism_Homo sapiens_hsa012000.67668490
98p53 signaling pathway_Homo sapiens_hsa041150.66295472
99RNA degradation_Homo sapiens_hsa030180.66084806
100Proteoglycans in cancer_Homo sapiens_hsa052050.65285409
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63376856
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62245134
103Colorectal cancer_Homo sapiens_hsa052100.60105891
104Chronic myeloid leukemia_Homo sapiens_hsa052200.59704924
105Vibrio cholerae infection_Homo sapiens_hsa051100.59252128
106Basal cell carcinoma_Homo sapiens_hsa052170.58487692
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58164125
108Rap1 signaling pathway_Homo sapiens_hsa040150.57888764
109Small cell lung cancer_Homo sapiens_hsa052220.57237474
110Notch signaling pathway_Homo sapiens_hsa043300.57218760
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56006695
112Fanconi anemia pathway_Homo sapiens_hsa034600.55970648
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.55782624
114Influenza A_Homo sapiens_hsa051640.52536264
115Folate biosynthesis_Homo sapiens_hsa007900.52524056
116Homologous recombination_Homo sapiens_hsa034400.51908036
117HIF-1 signaling pathway_Homo sapiens_hsa040660.51885368
118Viral carcinogenesis_Homo sapiens_hsa052030.51853217
119AMPK signaling pathway_Homo sapiens_hsa041520.51784733
120Endometrial cancer_Homo sapiens_hsa052130.51422827
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51237884
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.50366373
123Pancreatic cancer_Homo sapiens_hsa052120.50134226
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49973861
125Proteasome_Homo sapiens_hsa030500.48129801
126Amoebiasis_Homo sapiens_hsa051460.47952093
127Legionellosis_Homo sapiens_hsa051340.47943419
128HTLV-I infection_Homo sapiens_hsa051660.46793286
129N-Glycan biosynthesis_Homo sapiens_hsa005100.46619772
130Adherens junction_Homo sapiens_hsa045200.46551132
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46287890
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45977545
133Hedgehog signaling pathway_Homo sapiens_hsa043400.45499277
134Herpes simplex infection_Homo sapiens_hsa051680.45349979
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44609858
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43758346
137Choline metabolism in cancer_Homo sapiens_hsa052310.43688527
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42787578
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42131509
140Antigen processing and presentation_Homo sapiens_hsa046120.40725384
141Oocyte meiosis_Homo sapiens_hsa041140.40365877
142Wnt signaling pathway_Homo sapiens_hsa043100.40303697
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.39988438
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39725615
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39102715
146Lysosome_Homo sapiens_hsa041420.39052656
147Focal adhesion_Homo sapiens_hsa045100.38413516
148Systemic lupus erythematosus_Homo sapiens_hsa053220.34343456
149Selenocompound metabolism_Homo sapiens_hsa004500.33984859
150RNA polymerase_Homo sapiens_hsa030200.32580414
151Endocytosis_Homo sapiens_hsa041440.30470292
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.30454325
153Renal cell carcinoma_Homo sapiens_hsa052110.25232321
154Insulin resistance_Homo sapiens_hsa049310.24173997
155Sphingolipid metabolism_Homo sapiens_hsa006000.20947175
156Sulfur metabolism_Homo sapiens_hsa009200.19471858
157Collecting duct acid secretion_Homo sapiens_hsa049660.19028044
158Platelet activation_Homo sapiens_hsa046110.16333867

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