WARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)6.79736580
2daunorubicin metabolic process (GO:0044597)6.79736580
3polyketide metabolic process (GO:0030638)6.79736580
4aminoglycoside antibiotic metabolic process (GO:0030647)4.20834468
5ribosomal small subunit biogenesis (GO:0042274)4.17584511
6ribosomal large subunit biogenesis (GO:0042273)4.16479594
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14927934
8maturation of SSU-rRNA (GO:0030490)3.98775303
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.96569538
10establishment of integrated proviral latency (GO:0075713)3.90703815
11IMP metabolic process (GO:0046040)3.88484368
12double-strand break repair via nonhomologous end joining (GO:0006303)3.85067749
13non-recombinational repair (GO:0000726)3.85067749
14formation of translation preinitiation complex (GO:0001731)3.82793244
15proteasome assembly (GO:0043248)3.81363037
16DNA deamination (GO:0045006)3.79599228
17rRNA modification (GO:0000154)3.78219898
18ribonucleoprotein complex biogenesis (GO:0022613)3.70040608
19DNA ligation (GO:0006266)3.64332242
20termination of RNA polymerase III transcription (GO:0006386)3.61013182
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.61013182
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.56923155
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.56923155
24purine nucleobase biosynthetic process (GO:0009113)3.54015696
25negative regulation of ligase activity (GO:0051352)3.52155388
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.52155388
27* tRNA aminoacylation for protein translation (GO:0006418)3.48774680
28energy homeostasis (GO:0097009)3.47935752
29* amino acid activation (GO:0043038)3.41567481
30* tRNA aminoacylation (GO:0043039)3.41567481
31termination of RNA polymerase I transcription (GO:0006363)3.41520264
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40463474
33translation (GO:0006412)3.39766516
34ATP synthesis coupled proton transport (GO:0015986)3.36445008
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36445008
36translational termination (GO:0006415)3.34817582
37AMP metabolic process (GO:0046033)3.34304395
38cotranslational protein targeting to membrane (GO:0006613)3.33136615
39viral transcription (GO:0019083)3.31517382
40protein targeting to ER (GO:0045047)3.31063248
41regulation of cellular amino acid metabolic process (GO:0006521)3.28828054
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27735902
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27735902
44DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27352594
45detection of molecule of bacterial origin (GO:0032490)3.25861909
46translational initiation (GO:0006413)3.25563417
47kinetochore assembly (GO:0051382)3.24411440
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22345210
49rRNA methylation (GO:0031167)3.21171464
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.20719017
51signal transduction involved in DNA damage checkpoint (GO:0072422)3.20719017
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.20369766
53mitotic sister chromatid cohesion (GO:0007064)3.20099756
54positive regulation of ligase activity (GO:0051351)3.18712261
55tRNA methylation (GO:0030488)3.18231118
56oxidative phosphorylation (GO:0006119)3.17500726
57DNA integration (GO:0015074)3.17460399
58nucleobase biosynthetic process (GO:0046112)3.17380402
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.17079723
60metaphase plate congression (GO:0051310)3.16864049
61cellular component biogenesis (GO:0044085)3.16544143
62mitochondrial RNA metabolic process (GO:0000959)3.16013313
63spliceosomal snRNP assembly (GO:0000387)3.15774071
64protein localization to endoplasmic reticulum (GO:0070972)3.14760167
65transcription from mitochondrial promoter (GO:0006390)3.09357916
66establishment of viral latency (GO:0019043)3.08319455
67transcription elongation from RNA polymerase I promoter (GO:0006362)3.07290285
68cullin deneddylation (GO:0010388)3.06753288
69negative regulation of nitric-oxide synthase activity (GO:0051001)3.06155051
70translational elongation (GO:0006414)3.05317743
71protein targeting to mitochondrion (GO:0006626)3.02874646
72transcription from RNA polymerase I promoter (GO:0006360)3.01015678
73regulation of translational fidelity (GO:0006450)2.99679951
74DNA catabolic process, exonucleolytic (GO:0000738)2.99508862
75regulation of nuclear cell cycle DNA replication (GO:0033262)2.98929975
76branched-chain amino acid catabolic process (GO:0009083)2.98753821
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98419030
78negative regulation by host of viral transcription (GO:0043922)2.96924871
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96914701
80* tRNA metabolic process (GO:0006399)2.95732659
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94750572
82folic acid-containing compound biosynthetic process (GO:0009396)2.93327401
83negative regulation of mast cell activation (GO:0033004)2.92949929
84protein K6-linked ubiquitination (GO:0085020)2.92334264
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92093325
86regulation of mitotic spindle checkpoint (GO:1903504)2.92093325
87kinetochore organization (GO:0051383)2.91761516
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91382341
89protein localization to kinetochore (GO:0034501)2.89186163
90cell cycle G1/S phase transition (GO:0044843)2.89041823
91G1/S transition of mitotic cell cycle (GO:0000082)2.89041823
92regulation of ubiquitin-protein transferase activity (GO:0051438)2.88826073
93DNA replication initiation (GO:0006270)2.87606888
94L-serine metabolic process (GO:0006563)2.87366489
95regulation of ligase activity (GO:0051340)2.87302683
96nucleotide-excision repair, DNA gap filling (GO:0006297)2.87015358
97regulation of fever generation (GO:0031620)2.86058242
98negative regulation of nitric oxide biosynthetic process (GO:0045019)2.85240951
99signal peptide processing (GO:0006465)2.84955759
100DNA replication checkpoint (GO:0000076)2.84069242
101maturation of 5.8S rRNA (GO:0000460)2.79232867
102ribosome assembly (GO:0042255)2.75205212
103CENP-A containing nucleosome assembly (GO:0034080)2.74496609
104positive regulation of protein sumoylation (GO:0033235)2.74404602
105transcription initiation from RNA polymerase I promoter (GO:0006361)2.73561658
106GMP metabolic process (GO:0046037)2.73001911
107pseudouridine synthesis (GO:0001522)2.72379156
108ribosome biogenesis (GO:0042254)2.72137946
109telomere maintenance via semi-conservative replication (GO:0032201)2.71022451
110histone H2A acetylation (GO:0043968)2.69791176
111telomere maintenance via recombination (GO:0000722)2.68866627
112DNA-dependent DNA replication (GO:0006261)2.68781491
113IMP biosynthetic process (GO:0006188)2.66440837
114replication fork processing (GO:0031297)2.62188194
115auditory receptor cell stereocilium organization (GO:0060088)2.60496926
116transcription-coupled nucleotide-excision repair (GO:0006283)2.59590705
117regulation of double-strand break repair via homologous recombination (GO:0010569)2.59507459
118regulation of mitochondrial translation (GO:0070129)2.57369032
119DNA strand elongation (GO:0022616)2.55328602
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.54531110
121positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54057948
122amino sugar catabolic process (GO:0046348)2.53470793
123DNA strand elongation involved in DNA replication (GO:0006271)2.52735858
124ribosomal small subunit assembly (GO:0000028)2.51929501
1257-methylguanosine mRNA capping (GO:0006370)2.51559275
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50779444
127regulation of activation of Janus kinase activity (GO:0010533)2.50575658
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.50279300
129positive regulation of gamma-delta T cell activation (GO:0046645)2.50002699
130mismatch repair (GO:0006298)2.49565108
131RNA capping (GO:0036260)2.48239380
1327-methylguanosine RNA capping (GO:0009452)2.48239380
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47823143
134peptidyl-histidine modification (GO:0018202)2.44767259
135DNA double-strand break processing (GO:0000729)2.44366743
136RNA methylation (GO:0001510)2.44364526
137regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.44050734
138detection of external biotic stimulus (GO:0098581)2.41744724
139L-methionine salvage (GO:0071267)2.41051747
140L-methionine biosynthetic process (GO:0071265)2.41051747
141amino acid salvage (GO:0043102)2.41051747
142rRNA processing (GO:0006364)2.40398725
143chaperone mediated protein folding requiring cofactor (GO:0051085)2.40061792
144mitotic recombination (GO:0006312)2.39064082
145mitochondrial DNA replication (GO:0006264)2.39022434
146chromatin remodeling at centromere (GO:0031055)2.38922773
147negative regulation of macroautophagy (GO:0016242)2.38548308
148negative regulation of interleukin-12 production (GO:0032695)2.36509584
149antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36005516
150pericardium development (GO:0060039)2.35799911
151viral mRNA export from host cell nucleus (GO:0046784)2.35386364
152positive regulation of DNA-dependent DNA replication (GO:2000105)2.34444160
153DNA damage response, detection of DNA damage (GO:0042769)2.34279026
154mitotic metaphase plate congression (GO:0007080)2.33786557
155guanosine-containing compound biosynthetic process (GO:1901070)2.31934713
156signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.31920393
157signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.31920393
158signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.31920393
159regulation of DNA damage checkpoint (GO:2000001)2.31909598
160rRNA metabolic process (GO:0016072)2.30515603
161N-acetylneuraminate metabolic process (GO:0006054)2.30401689
162tRNA modification (GO:0006400)2.29319682
163interferon-gamma production (GO:0032609)2.29240554
164intra-S DNA damage checkpoint (GO:0031573)2.29208123
165NIK/NF-kappaB signaling (GO:0038061)2.29014381
166regulation of glucokinase activity (GO:0033131)2.28396287
167regulation of hexokinase activity (GO:1903299)2.28396287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.87354746
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.86431699
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57795628
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42684164
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10422899
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.06358082
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93777127
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.93275078
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.90145760
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.89291734
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88430052
12* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86334438
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.75037484
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.61629295
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.51932397
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.51882489
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38486357
18* VDR_23849224_ChIP-Seq_CD4+_Human2.28800404
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28497950
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.26607424
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16900325
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10933357
23* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08831236
24* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.08617201
25ELK1_19687146_ChIP-ChIP_HELA_Human2.01300258
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96435114
27FOXP3_21729870_ChIP-Seq_TREG_Human1.92445659
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.89476163
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87475452
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81675922
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.81216294
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80817573
33* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79929117
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78578330
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78433573
36* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75211312
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73521286
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71144644
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70879252
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.68437483
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65035907
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64285252
43KDM5A_27292631_Chip-Seq_BREAST_Human1.64105416
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59807456
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57904382
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.55963822
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54986551
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53069991
49DCP1A_22483619_ChIP-Seq_HELA_Human1.52909597
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51998569
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51711080
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50349490
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46776527
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.46429813
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44958197
56GABP_19822575_ChIP-Seq_HepG2_Human1.43562277
57IRF1_19129219_ChIP-ChIP_H3396_Human1.42978522
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40195452
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39485227
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38026568
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37978676
62EWS_26573619_Chip-Seq_HEK293_Human1.37694899
63CIITA_25753668_ChIP-Seq_RAJI_Human1.36526686
64SPI1_23547873_ChIP-Seq_NB4_Human1.36216139
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.35457468
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33252548
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31901005
68MYC_18940864_ChIP-ChIP_HL60_Human1.30800954
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29128826
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26217552
71* FOXM1_23109430_ChIP-Seq_U2OS_Human1.25245110
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24386401
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.24048233
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23542773
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22603563
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21929506
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21544269
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.20640405
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20494528
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19977537
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18578995
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17233730
83AR_21909140_ChIP-Seq_LNCAP_Human1.15543601
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15330130
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15322308
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14819868
87* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13842906
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13584150
89* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12405501
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10859320
91TFEB_21752829_ChIP-Seq_HELA_Human1.10316071
92* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09148951
93* XRN2_22483619_ChIP-Seq_HELA_Human1.09147887
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08861448
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08539104
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.08371090
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08180710
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.07782707
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07243465
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06200801
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05641023
102* TTF2_22483619_ChIP-Seq_HELA_Human1.03181494
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02520517
104SOX17_20123909_ChIP-Seq_XEN_Mouse1.02105079
105KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01782123
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01714781
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00144222
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99981592
109FUS_26573619_Chip-Seq_HEK293_Human0.96923991
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95619327
111* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94901727
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94062340
113* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93739843
114STAT3_18555785_Chip-Seq_ESCs_Mouse0.93093667
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93074700
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91687139
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87594768
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87249907
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86863876
120VDR_22108803_ChIP-Seq_LS180_Human0.86680686
121MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86600138
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85435698
123NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84767674
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79088287
125* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78210597
126ELF5_23300383_ChIP-Seq_T47D_Human0.77582948
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76041183
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74907723
129ZNF263_19887448_ChIP-Seq_K562_Human0.74370164
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.71975771
131* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71810917
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71718087
133* CHD1_26751641_Chip-Seq_LNCaP_Human0.71358721
134* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.69185780
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.65044997
136TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63928301
137TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63275890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.42311930
2MP0009697_abnormal_copulation3.24563068
3MP0003136_yellow_coat_color3.03423246
4MP0002396_abnormal_hematopoietic_system2.94722118
5MP0005671_abnormal_response_to2.87504012
6MP0010094_abnormal_chromosome_stability2.71210522
7MP0008058_abnormal_DNA_repair2.70059720
8MP0005171_absent_coat_pigmentation2.62094301
9MP0001188_hyperpigmentation2.56736336
10MP0005377_hearing/vestibular/ear_phenot2.49961607
11MP0003878_abnormal_ear_physiology2.49961607
12MP0003806_abnormal_nucleotide_metabolis2.47230671
13MP0003693_abnormal_embryo_hatching2.46246855
14MP0003111_abnormal_nucleus_morphology2.40151367
15MP0003186_abnormal_redox_activity2.34685866
16MP0008260_abnormal_autophagy2.31476871
17MP0001986_abnormal_taste_sensitivity2.14605312
18MP0008057_abnormal_DNA_replication2.11381019
19MP0003077_abnormal_cell_cycle2.08409293
20MP0001835_abnormal_antigen_presentation2.08165877
21MP0001853_heart_inflammation2.07176275
22MP0002132_abnormal_respiratory_system1.99237186
23MP0008007_abnormal_cellular_replicative1.87624023
24MP0003786_premature_aging1.85413040
25MP0002876_abnormal_thyroid_physiology1.81363056
26MP0006036_abnormal_mitochondrial_physio1.81102515
27MP0003941_abnormal_skin_development1.75188647
28MP0009379_abnormal_foot_pigmentation1.73664207
29MP0002938_white_spotting1.70697224
30MP0006035_abnormal_mitochondrial_morpho1.68909775
31MP0003763_abnormal_thymus_physiology1.65884647
32MP0003718_maternal_effect1.64872179
33MP0005174_abnormal_tail_pigmentation1.64205641
34MP0002638_abnormal_pupillary_reflex1.62742219
35MP0002163_abnormal_gland_morphology1.57000484
36MP0001790_abnormal_immune_system1.55698924
37MP0005387_immune_system_phenotype1.55698924
38MP0001730_embryonic_growth_arrest1.52009760
39MP0000350_abnormal_cell_proliferation1.49792392
40MP0002095_abnormal_skin_pigmentation1.49777176
41MP0008004_abnormal_stomach_pH1.48995023
42MP0001697_abnormal_embryo_size1.45549433
43MP0001542_abnormal_bone_strength1.45496099
44MP0003191_abnormal_cellular_cholesterol1.44873781
45MP0000685_abnormal_immune_system1.44568660
46MP0002277_abnormal_respiratory_mucosa1.44052402
47MP0001800_abnormal_humoral_immune1.42600484
48MP0001764_abnormal_homeostasis1.42072552
49MP0008789_abnormal_olfactory_epithelium1.39709109
50MP0010030_abnormal_orbit_morphology1.39232609
51MP0009333_abnormal_splenocyte_physiolog1.38346171
52MP0001879_abnormal_lymphatic_vessel1.37965998
53MP0009785_altered_susceptibility_to1.37742473
54MP0000015_abnormal_ear_pigmentation1.34147083
55MP0005075_abnormal_melanosome_morpholog1.32365930
56MP0005670_abnormal_white_adipose1.32144760
57MP0004808_abnormal_hematopoietic_stem1.31061161
58MP0002452_abnormal_antigen_presenting1.29952341
59MP0008995_early_reproductive_senescence1.29083699
60MP0003828_pulmonary_edema1.27307994
61MP0002138_abnormal_hepatobiliary_system1.26810098
62MP0002398_abnormal_bone_marrow1.26656491
63MP0000358_abnormal_cell_content/1.25939302
64MP0001819_abnormal_immune_cell1.25444965
65MP0002420_abnormal_adaptive_immunity1.24435523
66MP0000313_abnormal_cell_death1.22781084
67MP0004147_increased_porphyrin_level1.22732670
68MP0003315_abnormal_perineum_morphology1.20791452
69MP0008877_abnormal_DNA_methylation1.20413928
70MP0002080_prenatal_lethality1.19111975
71MP0005380_embryogenesis_phenotype1.18606396
72MP0001672_abnormal_embryogenesis/_devel1.18606396
73MP0002723_abnormal_immune_serum1.17439618
74MP0002210_abnormal_sex_determination1.17330847
75MP0006072_abnormal_retinal_apoptosis1.16128143
76MP0002148_abnormal_hypersensitivity_rea1.14748401
77MP0002160_abnormal_reproductive_system1.14127397
78MP0004957_abnormal_blastocyst_morpholog1.13790038
79MP0000716_abnormal_immune_system1.13676431
80MP0003567_abnormal_fetal_cardiomyocyte1.12753366
81MP0003950_abnormal_plasma_membrane1.11648107
82MP0002419_abnormal_innate_immunity1.11576094
83MP0002722_abnormal_immune_system1.10175246
84MP0001929_abnormal_gametogenesis1.09748910
85MP0001293_anophthalmia1.09744328
86MP0004782_abnormal_surfactant_physiolog1.07660494
87MP0003943_abnormal_hepatobiliary_system1.06856696
88MP0003221_abnormal_cardiomyocyte_apopto1.05939725
89MP0000372_irregular_coat_pigmentation1.05313907
90MP0000490_abnormal_crypts_of1.05051002
91MP0000013_abnormal_adipose_tissue1.04499789
92MP0002429_abnormal_blood_cell1.04291142
93MP0001873_stomach_inflammation1.03529009
94MP0005360_urolithiasis1.03269219
95MP0003984_embryonic_growth_retardation1.03142329
96MP0002088_abnormal_embryonic_growth/wei1.00346487
97MP0001186_pigmentation_phenotype0.99926809
98MP0000689_abnormal_spleen_morphology0.98285764
99MP0001145_abnormal_male_reproductive0.96824067
100MP0000703_abnormal_thymus_morphology0.96153306
101MP0005645_abnormal_hypothalamus_physiol0.94947197
102MP0010307_abnormal_tumor_latency0.94512360
103MP0008932_abnormal_embryonic_tissue0.93940246
104MP0002084_abnormal_developmental_patter0.93690143
105MP0000653_abnormal_sex_gland0.93278234
106MP0005025_abnormal_response_to0.93253758
107MP0002019_abnormal_tumor_incidence0.92732890
108MP0010352_gastrointestinal_tract_polyps0.92257747
109MP0002085_abnormal_embryonic_tissue0.91473910
110MP0005408_hypopigmentation0.91144505
111MP0000681_abnormal_thyroid_gland0.91033962
112MP0009764_decreased_sensitivity_to0.90774315
113MP0010155_abnormal_intestine_physiology0.90474490
114MP0001119_abnormal_female_reproductive0.89802104
115MP0003879_abnormal_hair_cell0.88737029
116MP0001545_abnormal_hematopoietic_system0.88310815
117MP0005397_hematopoietic_system_phenotyp0.88310815
118MP0003937_abnormal_limbs/digits/tail_de0.88139764
119MP0005395_other_phenotype0.87893365
120MP0002751_abnormal_autonomic_nervous0.86471002
121MP0005083_abnormal_biliary_tract0.86279573
122MP0002405_respiratory_system_inflammati0.85759178
123MP0009672_abnormal_birth_weight0.85623651
124MP0003646_muscle_fatigue0.85348053
125MP0005409_darkened_coat_color0.85334901
126MP0001661_extended_life_span0.85128015
127MP0005332_abnormal_amino_acid0.84777817
128MP0002009_preneoplasia0.84436324
129MP0003656_abnormal_erythrocyte_physiolo0.83980624
130MP0004133_heterotaxia0.83316833
131MP0002269_muscular_atrophy0.82528599
132MP0004233_abnormal_muscle_weight0.82300542
133MP0002075_abnormal_coat/hair_pigmentati0.82245143
134MP0005000_abnormal_immune_tolerance0.82229356
135MP0002877_abnormal_melanocyte_morpholog0.81116816
136MP0009780_abnormal_chondrocyte_physiolo0.80875957
137MP0002697_abnormal_eye_size0.79744480
138MP0004264_abnormal_extraembryonic_tissu0.79372582
139MP0005330_cardiomyopathy0.79181704
140MP0001346_abnormal_lacrimal_gland0.78598921
141MP0000749_muscle_degeneration0.78189108
142MP0000647_abnormal_sebaceous_gland0.76434833
143MP0000750_abnormal_muscle_regeneration0.75331708
144MP0005379_endocrine/exocrine_gland_phen0.74916308
145MP0001919_abnormal_reproductive_system0.73037065
146MP0010386_abnormal_urinary_bladder0.71295648
147MP0000678_abnormal_parathyroid_gland0.71044411
148MP0005389_reproductive_system_phenotype0.70714717
149MP0000613_abnormal_salivary_gland0.70535137
150MP0004197_abnormal_fetal_growth/weight/0.69613195
151MP0003724_increased_susceptibility_to0.66723075
152MP0005636_abnormal_mineral_homeostasis0.66524387
153MP0000627_abnormal_mammary_gland0.65417691
154MP0001286_abnormal_eye_development0.64663174
155MP0002086_abnormal_extraembryonic_tissu0.64581649
156MP0002233_abnormal_nose_morphology0.62029059
157MP0005253_abnormal_eye_physiology0.61076842
158MP0005623_abnormal_meninges_morphology0.59888095
159MP0004272_abnormal_basement_membrane0.57676248
160MP0003936_abnormal_reproductive_system0.57395388
161MP0005384_cellular_phenotype0.57222494
162MP0005391_vision/eye_phenotype0.57018603
163MP0005501_abnormal_skin_physiology0.56358093
164MP0002102_abnormal_ear_morphology0.56233762

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.43200965
2Increased hepatocellular lipid droplets (HP:0006565)4.27921024
3Lipid accumulation in hepatocytes (HP:0006561)4.09853372
4Chromsome breakage (HP:0040012)4.03299148
5Acute necrotizing encephalopathy (HP:0006965)4.03200815
6Increased serum pyruvate (HP:0003542)3.90837604
7Abnormal mitochondria in muscle tissue (HP:0008316)3.86094237
8Acute encephalopathy (HP:0006846)3.84781573
9Abnormality of glycolysis (HP:0004366)3.73681007
10Increased CSF lactate (HP:0002490)3.70701558
11Mitochondrial inheritance (HP:0001427)3.60896395
12Hepatocellular necrosis (HP:0001404)3.40021344
13Cerebral edema (HP:0002181)3.38788139
14Birth length less than 3rd percentile (HP:0003561)3.35807526
15Hepatic necrosis (HP:0002605)3.27011606
16Retrobulbar optic neuritis (HP:0100654)3.23046007
17Optic neuritis (HP:0100653)3.23046007
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.21617364
19Abnormality of the preputium (HP:0100587)3.19241182
20Progressive macrocephaly (HP:0004481)3.18161111
21Meckel diverticulum (HP:0002245)3.14102584
22Abnormality of methionine metabolism (HP:0010901)3.08568540
23Increased serum lactate (HP:0002151)3.07694751
24Renal Fanconi syndrome (HP:0001994)3.06615192
25White forelock (HP:0002211)3.00074028
26Abnormality of the ileum (HP:0001549)2.90590586
27Patchy hypopigmentation of hair (HP:0011365)2.88170422
28Type 2 muscle fiber atrophy (HP:0003554)2.87182054
29Cheilitis (HP:0100825)2.85261010
30Increased intramyocellular lipid droplets (HP:0012240)2.83719208
31Absent eyelashes (HP:0000561)2.80860778
32Ectopic kidney (HP:0000086)2.76101149
33Pancreatic fibrosis (HP:0100732)2.71849834
34Clubbing of toes (HP:0100760)2.71805480
35Macrocytic anemia (HP:0001972)2.70920319
36Pancreatic cysts (HP:0001737)2.70072237
37Absent eyebrow (HP:0002223)2.67194020
38Duplicated collecting system (HP:0000081)2.66024759
39Abnormality of chromosome stability (HP:0003220)2.65128253
40Abnormality of dental color (HP:0011073)2.64445443
41Aplastic anemia (HP:0001915)2.53977410
42Premature ovarian failure (HP:0008209)2.53568602
43Exercise intolerance (HP:0003546)2.52365150
44Abnormality of the renal collecting system (HP:0004742)2.51119477
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50974035
46Lactic acidosis (HP:0003128)2.50433337
47Submucous cleft hard palate (HP:0000176)2.48512207
48Orchitis (HP:0100796)2.47623346
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47068308
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47068308
51Myositis (HP:0100614)2.45408573
52Pancytopenia (HP:0001876)2.43768932
53Carpal bone hypoplasia (HP:0001498)2.42570299
54Increased muscle lipid content (HP:0009058)2.40722684
55True hermaphroditism (HP:0010459)2.39903183
56Chronic diarrhea (HP:0002028)2.38920593
57Respiratory difficulties (HP:0002880)2.38407831
58Abnormal lung lobation (HP:0002101)2.35729009
59Muscle fiber atrophy (HP:0100295)2.35567492
60Abnormality of DNA repair (HP:0003254)2.33975217
61Progressive external ophthalmoplegia (HP:0000590)2.33632471
62Abnormal protein glycosylation (HP:0012346)2.31765464
63Abnormal glycosylation (HP:0012345)2.31765464
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31765464
65Abnormal protein N-linked glycosylation (HP:0012347)2.31765464
66Unilateral renal agenesis (HP:0000122)2.31601415
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31227034
68Generalized aminoaciduria (HP:0002909)2.29986254
69Microvesicular hepatic steatosis (HP:0001414)2.29346210
70Hypoplasia of the thymus (HP:0000778)2.29264935
71Microretrognathia (HP:0000308)2.29056126
72Alopecia of scalp (HP:0002293)2.27458062
73Alveolar cell carcinoma (HP:0006519)2.26286981
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25984721
75Respiratory failure (HP:0002878)2.25943117
76Acanthocytosis (HP:0001927)2.25412563
77Secondary amenorrhea (HP:0000869)2.24936229
78Nephroblastoma (Wilms tumor) (HP:0002667)2.22397395
79Abnormality of serum amino acid levels (HP:0003112)2.21473114
80Reduced subcutaneous adipose tissue (HP:0003758)2.18058981
81Lethargy (HP:0001254)2.17958540
82Reticulocytopenia (HP:0001896)2.17714501
83Parakeratosis (HP:0001036)2.17016367
84Small intestinal stenosis (HP:0012848)2.15927385
85Duodenal stenosis (HP:0100867)2.15927385
86Cerebral hypomyelination (HP:0006808)2.13580186
87IgG deficiency (HP:0004315)2.13288386
88Abnormality of cells of the erythroid lineage (HP:0012130)2.13043654
89Testicular atrophy (HP:0000029)2.12583937
90Megaloblastic anemia (HP:0001889)2.11954247
91Embryonal renal neoplasm (HP:0011794)2.11388320
92Dyschromatopsia (HP:0007641)2.09514764
93Glucose intolerance (HP:0000833)2.08147795
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07830768
95Bone marrow hypocellularity (HP:0005528)2.07247102
96Keratitis (HP:0000491)2.04071926
97Recurrent pneumonia (HP:0006532)2.02998567
98Pallor (HP:0000980)2.02930728
99Renal cortical cysts (HP:0000803)2.02509549
100Abnormality of the umbilical cord (HP:0010881)2.02091914
101Exertional dyspnea (HP:0002875)2.01659533
102Prolonged neonatal jaundice (HP:0006579)2.01464494
103Abnormal number of erythroid precursors (HP:0012131)2.00628874
104Myelodysplasia (HP:0002863)2.00230426
105Premature graying of hair (HP:0002216)2.00209265
106Osteomalacia (HP:0002749)2.00046086
107Short middle phalanx of the 5th finger (HP:0004220)1.98449245
108Progressive muscle weakness (HP:0003323)1.97087477
109Hypergonadotropic hypogonadism (HP:0000815)1.95725264
110Abnormality of sulfur amino acid metabolism (HP:0004339)1.95618149
111Abnormality of alanine metabolism (HP:0010916)1.95398511
112Hyperalaninemia (HP:0003348)1.95398511
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95398511
114Chronic hepatic failure (HP:0100626)1.95250392
115Keratoconjunctivitis sicca (HP:0001097)1.91955935
116Type I transferrin isoform profile (HP:0003642)1.91727725
117Postnatal microcephaly (HP:0005484)1.90893912
118Albinism (HP:0001022)1.89141545
119CNS demyelination (HP:0007305)1.88012260
120Ureteral duplication (HP:0000073)1.87846340
121Abnormal biliary tract physiology (HP:0012439)1.87630786
122Bile duct proliferation (HP:0001408)1.87630786
123Cortical dysplasia (HP:0002539)1.87433159
124Oligohydramnios (HP:0001562)1.87006599
125Encephalitis (HP:0002383)1.86357738
126Degeneration of anterior horn cells (HP:0002398)1.85741593
127Abnormality of the anterior horn cell (HP:0006802)1.85741593
128Absent thumb (HP:0009777)1.85386826
129Neoplasm of the tracheobronchial system (HP:0100552)1.85216158
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84276969
131Self-mutilation (HP:0000742)1.82950664
132IgM deficiency (HP:0002850)1.82620442
133Abnormality of the carotid arteries (HP:0005344)1.82084939
134Congenital sensorineural hearing impairment (HP:0008527)1.82060949
135Bilateral sensorineural hearing impairment (HP:0008619)1.81608831
136Multiple enchondromatosis (HP:0005701)1.79335871
137Volvulus (HP:0002580)1.78665588
138Blepharitis (HP:0000498)1.78020408
139Glomerulopathy (HP:0100820)1.77984170
140Optic nerve coloboma (HP:0000588)1.77693354
141Abnormality of the duodenum (HP:0002246)1.77278669
142Triphalangeal thumb (HP:0001199)1.77054921
143Patellar aplasia (HP:0006443)1.76780269
144Supernumerary spleens (HP:0009799)1.76778045
145Elevated erythrocyte sedimentation rate (HP:0003565)1.75809581
146Hypokinesia (HP:0002375)1.75692912
1473-Methylglutaconic aciduria (HP:0003535)1.75675565
148Breast hypoplasia (HP:0003187)1.75525407
149CNS hypomyelination (HP:0003429)1.74735066
150Sloping forehead (HP:0000340)1.74680327
151Tubulointerstitial nephritis (HP:0001970)1.73933787
152Fibular aplasia (HP:0002990)1.73910246
153Horseshoe kidney (HP:0000085)1.73266901
154Abnormality of renal resorption (HP:0011038)1.73123118
155Sensory axonal neuropathy (HP:0003390)1.72606888
156Cleft eyelid (HP:0000625)1.72597877
157Keratoconjunctivitis (HP:0001096)1.71962723
158Increased number of teeth (HP:0011069)1.71604213
159Optic disc pallor (HP:0000543)1.71493605
160Abnormality of urine glucose concentration (HP:0011016)1.71479863
161Glycosuria (HP:0003076)1.71479863
162Hypobetalipoproteinemia (HP:0003563)1.71411292
163Rhabdomyosarcoma (HP:0002859)1.71173133
164Sparse eyelashes (HP:0000653)1.71100462
165Absent hair (HP:0002298)1.70826430
166Aplasia/Hypoplasia of the patella (HP:0006498)1.70090627
167Lymphoma (HP:0002665)1.70021744
168Absent radius (HP:0003974)1.68886902
169Reduced antithrombin III activity (HP:0001976)1.68153246
170Aplasia/Hypoplasia of the fovea (HP:0008060)1.65533360
171Hypoplasia of the fovea (HP:0007750)1.65533360
172Impulsivity (HP:0100710)1.64561877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.74670136
2SIK33.48912445
3VRK23.03334242
4SRPK13.00029005
5STK162.92632720
6IRAK32.91726405
7NEK12.71932379
8ZAK2.63427546
9PDK22.58888530
10CDK82.51202898
11CASK2.37963905
12TTK2.35229283
13TXK2.30169361
14MKNK22.12422872
15TSSK62.11862477
16TRIM282.11452225
17BUB12.06042231
18PLK42.03399637
19NUAK11.99412489
20NME11.98931876
21NME21.96906712
22INSRR1.76683663
23EIF2AK21.74580293
24NEK91.72015698
25MAP3K141.71100565
26IRAK41.66768378
27MAP4K21.63832402
28SCYL21.62382964
29BMPR1B1.62303512
30SIK11.59983211
31TAOK21.58991605
32MKNK11.51647293
33WNK41.46460912
34WEE11.40079947
35BMPR21.39025140
36MST1R1.35534493
37EIF2AK11.29628386
38MARK31.27417411
39VRK11.27387098
40KDR1.25679550
41PBK1.18959501
42CLK11.18549729
43RPS6KA41.18497734
44SGK21.17596004
45EPHA21.17063688
46GRK11.16791853
47STK391.16202833
48BCKDK1.13194995
49BRD41.11100697
50STK38L1.10865554
51TIE11.10718971
52PASK1.08120278
53ADRBK21.07145641
54BRSK21.05006233
55PIM21.04375698
56ACVR1B1.03825452
57PLK31.01633196
58CCNB11.00947052
59RPS6KB21.00424991
60STK240.99702206
61IKBKB0.97835214
62EIF2AK30.95501016
63BCR0.95312941
64MAP4K10.94411383
65ATR0.93403390
66AURKA0.92778001
67CDK30.90681171
68MAP2K70.89467957
69TEC0.88696611
70BRAF0.85247253
71CDK40.84587357
72CDK70.84475351
73STK40.84249014
74SGK30.82804560
75JAK30.82539549
76TGFBR10.82043683
77STK30.81766040
78PIM10.79158301
79PLK10.79021199
80ERBB30.77382348
81CSNK1G10.76233573
82IKBKE0.75094282
83AURKB0.74155522
84NEK20.73781404
85ATM0.72785914
86TYK20.72720482
87YES10.72131036
88CHUK0.71550031
89WNK30.66899580
90DYRK30.65135740
91NLK0.63601576
92RPS6KA50.60283979
93CSNK1G30.58853440
94NEK60.57555332
95CHEK20.57280363
96SIK20.56884814
97CSNK1A1L0.56718374
98TGFBR20.56650255
99ABL20.56425686
100LRRK20.55412257
101TBK10.55299953
102PAK40.53678384
103MST40.52863967
104ZAP700.51187132
105MAP3K120.48120668
106OBSCN0.47681620
107IRAK10.47621129
108PRKAA20.46620761
109CSNK2A10.46083905
110BTK0.46069256
111CDK10.45768877
112TAF10.45252233
113CDK60.43676787
114MAP3K80.42945780
115MAP2K30.42825052
116CDK20.42784164
117MAP3K50.40539555
118MUSK0.40255451
119MAPK110.39669099
120IRAK20.39644518
121TLK10.38834742
122LYN0.37909344
123CHEK10.36185664
124TNIK0.35746653
125MAPK130.35599891
126PRKAA10.35360488
127PLK20.35248809
128PNCK0.34794153
129CDC70.34599105
130AKT20.34539083
131CSNK2A20.34421091
132MYLK0.34399119
133CDK90.32854986
134ILK0.32260132
135STK100.32042938
136CSNK1E0.31633847
137BRSK10.31174780
138ALK0.30768347
139FER0.30327038
140PRKDC0.29916589
141ERBB40.27873034
142FLT30.27325653
143CSNK1G20.25956037
144MELK0.25798871
145RPS6KB10.23587842
146TESK20.21907770
147PRKCI0.21535954
148MAPKAPK50.20595860
149MAP2K60.19754878

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.55506817
2DNA replication_Homo sapiens_hsa030303.07181964
3Mismatch repair_Homo sapiens_hsa034303.01147485
4Proteasome_Homo sapiens_hsa030502.97131447
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92083570
6Fanconi anemia pathway_Homo sapiens_hsa034602.78467920
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.70754198
8Homologous recombination_Homo sapiens_hsa034402.59308112
9Nucleotide excision repair_Homo sapiens_hsa034202.43314233
10Pyrimidine metabolism_Homo sapiens_hsa002402.42639837
11Oxidative phosphorylation_Homo sapiens_hsa001902.24617428
12Basal transcription factors_Homo sapiens_hsa030222.23236081
13Base excision repair_Homo sapiens_hsa034102.20865794
14Primary immunodeficiency_Homo sapiens_hsa053402.20012821
15Non-homologous end-joining_Homo sapiens_hsa034502.16153328
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03414248
17Vitamin B6 metabolism_Homo sapiens_hsa007502.03211598
18Parkinsons disease_Homo sapiens_hsa050121.93962512
19Cell cycle_Homo sapiens_hsa041101.91958113
20Spliceosome_Homo sapiens_hsa030401.80127549
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76787805
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.76324003
23RNA transport_Homo sapiens_hsa030131.72586090
24Regulation of autophagy_Homo sapiens_hsa041401.66034211
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.64468030
26Purine metabolism_Homo sapiens_hsa002301.63385889
27Pyruvate metabolism_Homo sapiens_hsa006201.60192480
28One carbon pool by folate_Homo sapiens_hsa006701.58148126
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57223478
30Huntingtons disease_Homo sapiens_hsa050161.53672138
31Measles_Homo sapiens_hsa051621.51944142
32Propanoate metabolism_Homo sapiens_hsa006401.51635646
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50443576
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50131907
35Ribosome_Homo sapiens_hsa030101.49638017
36Vitamin digestion and absorption_Homo sapiens_hsa049771.47724113
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47250452
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46543343
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45750293
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45181708
41Steroid biosynthesis_Homo sapiens_hsa001001.40877060
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36667383
43Biosynthesis of amino acids_Homo sapiens_hsa012301.32812354
44* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32690260
45p53 signaling pathway_Homo sapiens_hsa041151.32489850
46Herpes simplex infection_Homo sapiens_hsa051681.31270253
47Epstein-Barr virus infection_Homo sapiens_hsa051691.29431820
48RNA degradation_Homo sapiens_hsa030181.28182404
49Hematopoietic cell lineage_Homo sapiens_hsa046401.26117793
50Fatty acid elongation_Homo sapiens_hsa000621.23909748
51Carbon metabolism_Homo sapiens_hsa012001.23058099
52Glutathione metabolism_Homo sapiens_hsa004801.20885941
53Protein export_Homo sapiens_hsa030601.18668927
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16035288
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14397983
56NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13917235
57Alzheimers disease_Homo sapiens_hsa050101.12571484
58Antigen processing and presentation_Homo sapiens_hsa046121.12159536
59Allograft rejection_Homo sapiens_hsa053301.08796816
60Autoimmune thyroid disease_Homo sapiens_hsa053201.08236611
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05425361
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04767857
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00977021
64Folate biosynthesis_Homo sapiens_hsa007900.99952374
65Graft-versus-host disease_Homo sapiens_hsa053320.93432148
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90947384
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.89980542
68Sulfur metabolism_Homo sapiens_hsa009200.89915007
69Sulfur relay system_Homo sapiens_hsa041220.88778167
70Circadian rhythm_Homo sapiens_hsa047100.87877417
71Pentose phosphate pathway_Homo sapiens_hsa000300.86746231
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83320679
73Fructose and mannose metabolism_Homo sapiens_hsa000510.80859856
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.80399272
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74193253
76N-Glycan biosynthesis_Homo sapiens_hsa005100.73558233
77Retinol metabolism_Homo sapiens_hsa008300.73390566
78Influenza A_Homo sapiens_hsa051640.72762325
79Other glycan degradation_Homo sapiens_hsa005110.72234161
80HTLV-I infection_Homo sapiens_hsa051660.71151907
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68911703
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67670688
83Butanoate metabolism_Homo sapiens_hsa006500.64718050
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62958781
85Apoptosis_Homo sapiens_hsa042100.61579761
86Arginine biosynthesis_Homo sapiens_hsa002200.60295859
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59683215
88beta-Alanine metabolism_Homo sapiens_hsa004100.58893986
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56630811
90Viral myocarditis_Homo sapiens_hsa054160.56564217
91Legionellosis_Homo sapiens_hsa051340.55918996
92Arginine and proline metabolism_Homo sapiens_hsa003300.53939197
93Viral carcinogenesis_Homo sapiens_hsa052030.51875094
94TNF signaling pathway_Homo sapiens_hsa046680.51599423
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51157310
96Tyrosine metabolism_Homo sapiens_hsa003500.50236604
97mRNA surveillance pathway_Homo sapiens_hsa030150.49293143
98Rheumatoid arthritis_Homo sapiens_hsa053230.48318530
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47595906
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47123626
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.47106461
102Systemic lupus erythematosus_Homo sapiens_hsa053220.47026735
103Asthma_Homo sapiens_hsa053100.46829119
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.46737955
105Hepatitis B_Homo sapiens_hsa051610.45888630
106Galactose metabolism_Homo sapiens_hsa000520.45756082
107Oocyte meiosis_Homo sapiens_hsa041140.45502631
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43438312
109Fatty acid degradation_Homo sapiens_hsa000710.42529258
110Type I diabetes mellitus_Homo sapiens_hsa049400.41886507
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41844532
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41511089
113Fatty acid metabolism_Homo sapiens_hsa012120.41396541
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40759114
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39735133
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.38972886
117FoxO signaling pathway_Homo sapiens_hsa040680.38673120
118Sphingolipid metabolism_Homo sapiens_hsa006000.37675726
119Metabolic pathways_Homo sapiens_hsa011000.34395293
120Leishmaniasis_Homo sapiens_hsa051400.32883987
121Phenylalanine metabolism_Homo sapiens_hsa003600.32177000
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31370470
123Cardiac muscle contraction_Homo sapiens_hsa042600.30387719
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.30187218
125T cell receptor signaling pathway_Homo sapiens_hsa046600.30144223
126Peroxisome_Homo sapiens_hsa041460.28901681
127Chemical carcinogenesis_Homo sapiens_hsa052040.28706884
128Malaria_Homo sapiens_hsa051440.27717435
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.26830823
130Tryptophan metabolism_Homo sapiens_hsa003800.25685525
131Osteoclast differentiation_Homo sapiens_hsa043800.24901679
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24280220
133Tuberculosis_Homo sapiens_hsa051520.24179989
134B cell receptor signaling pathway_Homo sapiens_hsa046620.23742162
135Colorectal cancer_Homo sapiens_hsa052100.23739191
136Small cell lung cancer_Homo sapiens_hsa052220.23094681
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22679274
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22577949
139Selenocompound metabolism_Homo sapiens_hsa004500.20762876
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20760883
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19372136
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19113128
143Lysine degradation_Homo sapiens_hsa003100.18629802
144Renin-angiotensin system_Homo sapiens_hsa046140.18233067
145Hepatitis C_Homo sapiens_hsa051600.17150696
146Acute myeloid leukemia_Homo sapiens_hsa052210.16950651
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16795467
148Nitrogen metabolism_Homo sapiens_hsa009100.16701167
149TGF-beta signaling pathway_Homo sapiens_hsa043500.13200551

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »