WASF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.37840579
2embryonic process involved in female pregnancy (GO:0060136)4.78458726
3regulation of integrin activation (GO:0033623)4.51885162
4regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.46622127
5B cell receptor signaling pathway (GO:0050853)4.42222942
6interferon-gamma secretion (GO:0072643)4.33997409
7cellular response to exogenous dsRNA (GO:0071360)4.31603684
8negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.30477909
9megakaryocyte development (GO:0035855)4.19267454
10negative regulation of DNA-templated transcription, elongation (GO:0032785)4.16383742
11proline biosynthetic process (GO:0006561)4.01164131
12B cell mediated immunity (GO:0019724)3.91878120
13rRNA catabolic process (GO:0016075)3.88598438
14regulation of germinal center formation (GO:0002634)3.80159944
15DNA damage response, signal transduction resulting in transcription (GO:0042772)3.61594650
16RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.61588968
17positive regulation of organelle assembly (GO:1902117)3.59211155
18definitive hemopoiesis (GO:0060216)3.51760854
19regulation of platelet activation (GO:0010543)3.50780396
20positive regulation of protein homooligomerization (GO:0032464)3.50471499
21response to UV-C (GO:0010225)3.48429609
22positive regulation of antigen processing and presentation (GO:0002579)3.48379308
23negative regulation of B cell apoptotic process (GO:0002903)3.46136063
24regulation of antigen processing and presentation (GO:0002577)3.42898557
25regulation of B cell apoptotic process (GO:0002902)3.42521309
26negative thymic T cell selection (GO:0045060)3.38390841
27regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.37608241
28positive T cell selection (GO:0043368)3.37188174
29response to interferon-beta (GO:0035456)3.34560097
30establishment of apical/basal cell polarity (GO:0035089)3.31284536
31embryonic placenta development (GO:0001892)3.30975817
32apoptotic process involved in morphogenesis (GO:0060561)3.30545351
33regulation of interferon-beta biosynthetic process (GO:0045357)3.30527489
34nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.27609531
35replication fork processing (GO:0031297)3.25449444
36regulation of regulatory T cell differentiation (GO:0045589)3.25421551
37positive regulation of interferon-alpha production (GO:0032727)3.25338297
38cellular response to interferon-beta (GO:0035458)3.24583952
39growth hormone receptor signaling pathway (GO:0060396)3.24220627
40neutrophil activation involved in immune response (GO:0002283)3.21998004
41JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.20759442
42trophectodermal cell differentiation (GO:0001829)3.17472655
43negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.17459674
44positive regulation of T cell differentiation in thymus (GO:0033089)3.17273246
45cellular response to zinc ion (GO:0071294)3.16053413
46positive regulation of granulocyte differentiation (GO:0030854)3.14106597
47positive regulation by host of viral transcription (GO:0043923)3.12432020
48UV protection (GO:0009650)3.10816718
49cellular response to dsRNA (GO:0071359)3.09477767
50dosage compensation (GO:0007549)3.08440961
51mitotic G1 DNA damage checkpoint (GO:0031571)3.07533464
52transcription from mitochondrial promoter (GO:0006390)3.07147856
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05948777
54positive regulation by symbiont of host defense response (GO:0052509)3.03518495
55modulation by symbiont of host defense response (GO:0052031)3.03518495
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.03518495
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.03518495
58positive regulation by organism of defense response of other organism involved in symbiotic interact3.03518495
59modulation by symbiont of host immune response (GO:0052553)3.03518495
60negative T cell selection (GO:0043383)3.03434218
61regulation of interferon-alpha production (GO:0032647)3.02694709
62negative regulation of cell killing (GO:0031342)3.01923687
63negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01923687
64thrombin receptor signaling pathway (GO:0070493)3.00373979
65negative regulation of granulocyte differentiation (GO:0030853)2.97934094
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95697485
67positive regulation of natural killer cell differentiation (GO:0032825)2.93925718
68cellular response to growth hormone stimulus (GO:0071378)2.93684677
69thymic T cell selection (GO:0045061)2.93461785
70mast cell activation (GO:0045576)2.92512624
71regulation of translational fidelity (GO:0006450)2.92273674
72positive regulation of defense response to virus by host (GO:0002230)2.90765243
73positive regulation of glomerulus development (GO:0090193)2.90149382
74regulation of mesoderm development (GO:2000380)2.89404587
75interferon-gamma-mediated signaling pathway (GO:0060333)2.88119785
76regulation of sister chromatid cohesion (GO:0007063)2.83982891
77pinocytosis (GO:0006907)2.83116028
78mitotic G1/S transition checkpoint (GO:0044819)2.80033157
79regulation of female receptivity (GO:0045924)2.78908628
80regulation of interleukin-12 biosynthetic process (GO:0045075)2.76304245
81positive regulation of interferon-beta production (GO:0032728)2.76296408
82positive regulation of protein oligomerization (GO:0032461)2.76179820
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75945588
84regulation of RNA export from nucleus (GO:0046831)2.74944500
85positive regulation of gamma-delta T cell activation (GO:0046645)2.74916963
86T cell selection (GO:0045058)2.74163923
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73978432
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73978432
89response to host immune response (GO:0052572)2.73791680
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.73791680
91response to laminar fluid shear stress (GO:0034616)2.73600343
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.73386834
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.73386834
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.73386834
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.72334011
96antigen receptor-mediated signaling pathway (GO:0050851)2.72275400
97response to peptidoglycan (GO:0032494)2.72164153
98regulation of interferon-beta production (GO:0032648)2.69235835
99regulation of gamma-delta T cell differentiation (GO:0045586)2.69203096
100heterochromatin organization (GO:0070828)2.68993345
101negative regulation of interleukin-12 production (GO:0032695)2.68451062
102positive regulation of SMAD protein import into nucleus (GO:0060391)2.65970277
103positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64186045
104RNA destabilization (GO:0050779)2.64137667
105G1 DNA damage checkpoint (GO:0044783)2.63962216
106protein localization to endosome (GO:0036010)2.63887134
107detection of bacterium (GO:0016045)2.63084939
108phosphatidylethanolamine biosynthetic process (GO:0006646)2.62434059
109anatomical structure regression (GO:0060033)2.61935215
110mature B cell differentiation involved in immune response (GO:0002313)2.61831963
111angiogenesis involved in wound healing (GO:0060055)2.61454531
112myeloid cell activation involved in immune response (GO:0002275)2.59878054
113T-helper 1 type immune response (GO:0042088)2.59582295
114lymphocyte homeostasis (GO:0002260)2.59268436
115B cell homeostasis (GO:0001782)2.59008014
116positive regulation of interleukin-17 production (GO:0032740)2.57633618
117response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.56260349
118response to host (GO:0075136)2.56260349
119response to host defenses (GO:0052200)2.56260349
120regulation of protein homooligomerization (GO:0032462)2.54858148
121histone H4-K12 acetylation (GO:0043983)2.54485940
122negative regulation of bone mineralization (GO:0030502)2.54463409
123negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.53225588
124establishment of monopolar cell polarity (GO:0061162)2.52347392
125establishment or maintenance of monopolar cell polarity (GO:0061339)2.52347392
126regulation of alpha-beta T cell proliferation (GO:0046640)2.51875416
127proline metabolic process (GO:0006560)2.51657644
128negative regulation of cell cycle arrest (GO:0071157)2.51608635
129antigen processing and presentation of endogenous antigen (GO:0019883)2.51254719
130mitochondrial DNA metabolic process (GO:0032042)2.50897947
131formation of translation preinitiation complex (GO:0001731)2.48705400
132face development (GO:0060324)2.47779250
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.44869786
134somatic diversification of immune receptors via somatic mutation (GO:0002566)2.44869786
135positive regulation of histone deacetylation (GO:0031065)2.44692415
136negative regulation of RNA splicing (GO:0033119)2.44147919
137regulation of SMAD protein import into nucleus (GO:0060390)2.43903983
138meiotic chromosome segregation (GO:0045132)2.43352104
139regulation of gamma-delta T cell activation (GO:0046643)2.42845287
140positive regulation of chromosome segregation (GO:0051984)2.41921813
141intracellular estrogen receptor signaling pathway (GO:0030520)2.41359184
142embryonic camera-type eye development (GO:0031076)2.39838026
143DNA topological change (GO:0006265)2.37398336
144mRNA cleavage (GO:0006379)2.37046284
145negative regulation of mRNA processing (GO:0050686)2.36738551
146pre-miRNA processing (GO:0031054)2.33629810
147positive thymic T cell selection (GO:0045059)2.32141946
148embryonic eye morphogenesis (GO:0048048)2.31977607
149poly(A)+ mRNA export from nucleus (GO:0016973)2.30724069
150mitotic sister chromatid segregation (GO:0000070)2.29790243
151regulation of podosome assembly (GO:0071801)2.29512775
152developmental programmed cell death (GO:0010623)2.29045994
153mRNA stabilization (GO:0048255)2.27788708
154RNA stabilization (GO:0043489)2.27788708
155positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.27226219
156mitotic nuclear envelope disassembly (GO:0007077)2.26363440
157negative regulation of viral release from host cell (GO:1902187)2.25158382
158apoptotic process involved in development (GO:1902742)2.24417704
159positive regulation of B cell differentiation (GO:0045579)2.23783325
1603-UTR-mediated mRNA stabilization (GO:0070935)2.23753920
161regulation of posttranscriptional gene silencing (GO:0060147)2.23645150
162regulation of gene silencing by miRNA (GO:0060964)2.23645150
163regulation of gene silencing by RNA (GO:0060966)2.23645150
164base-excision repair (GO:0006284)2.21627351
165determination of adult lifespan (GO:0008340)2.21352709
166protein localization to kinetochore (GO:0034501)2.20941121
167spliceosomal tri-snRNP complex assembly (GO:0000244)2.20619612
168telomere maintenance via semi-conservative replication (GO:0032201)2.20366838
169negative regulation of interleukin-8 production (GO:0032717)2.20227143
170regulation of hippo signaling (GO:0035330)2.19324855
171positive regulation of cell adhesion mediated by integrin (GO:0033630)2.19308851
172DNA deamination (GO:0045006)2.19195805
173DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.18860624
174hepatocyte apoptotic process (GO:0097284)2.18187004
175sister chromatid segregation (GO:0000819)2.17945382
176DNA strand renaturation (GO:0000733)2.17013424
177retinoic acid receptor signaling pathway (GO:0048384)2.15475905
178hypotonic response (GO:0006971)2.14062427
179V(D)J recombination (GO:0033151)2.13301449
180regulation of B cell differentiation (GO:0045577)2.13204236
181negative regulation of glial cell proliferation (GO:0060253)2.12974522
182immunoglobulin mediated immune response (GO:0016064)2.12491795
183intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.12461271
184regulation of B cell receptor signaling pathway (GO:0050855)2.11883876
185negative regulation of mRNA metabolic process (GO:1903312)2.10739900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.54281374
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.13382084
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.76242695
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25469240
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.18381106
6MYC_22102868_ChIP-Seq_BL_Human3.11831686
7GATA1_22025678_ChIP-Seq_K562_Human3.01251054
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.99860935
9VDR_21846776_ChIP-Seq_THP-1_Human2.95915210
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93300389
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.58238507
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12032652
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.09639015
14CIITA_25753668_ChIP-Seq_RAJI_Human2.03563112
15TCF7_22412390_ChIP-Seq_EML_Mouse2.02675210
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.02565516
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94480921
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93423575
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93423575
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93423575
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.92779053
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89495317
23* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86986704
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.86482433
25* MAF_26560356_Chip-Seq_TH1_Human1.83116072
26KDM2B_26808549_Chip-Seq_DND41_Human1.82040438
27* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81896114
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81433389
29GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.81254419
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80298622
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77040503
32* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76970838
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76490137
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75575237
35* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75501258
36GATA1_19941827_ChIP-Seq_MEL_Mouse1.72488724
37VDR_24763502_ChIP-Seq_THP-1_Human1.71040363
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71040293
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70192683
40SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66045826
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64868621
42GATA1_19941826_ChIP-Seq_K562_Human1.63685516
43* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63107232
44* UTX_26944678_Chip-Seq_JUKART_Human1.62762212
45* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62443658
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58436188
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56810529
48GATA3_27048872_Chip-Seq_THYMUS_Human1.56692720
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54765519
50* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54663922
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54432477
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54382816
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54027122
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53300845
55GATA2_19941826_ChIP-Seq_K562_Human1.50044029
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.49702299
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45473535
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.44372757
59* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43318921
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42607206
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42158517
62* LXR_22292898_ChIP-Seq_THP-1_Human1.41543253
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41388330
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41256632
65* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40903684
66SCL_19346495_ChIP-Seq_HPC-7_Human1.40817105
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40803579
68* MYB_26560356_Chip-Seq_TH1_Human1.39674880
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39215884
70RACK7_27058665_Chip-Seq_MCF-7_Human1.39002279
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.38287567
72* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37047354
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36985157
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.35558425
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35504697
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35180936
77* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34833589
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33688069
79* MYB_26560356_Chip-Seq_TH2_Human1.32792932
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29959297
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29220795
82* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27046579
83SPI1_23547873_ChIP-Seq_NB4_Human1.26771711
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.26345720
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25473220
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25345388
87VDR_24787735_ChIP-Seq_THP-1_Human1.24608428
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24327020
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23454041
90MAF_26560356_Chip-Seq_TH2_Human1.22339113
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21930824
92GATA3_26560356_Chip-Seq_TH2_Human1.21474755
93* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20647632
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20260508
95* NCOR1_26117541_ChIP-Seq_K562_Human1.20094958
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17510094
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16991283
98BP1_19119308_ChIP-ChIP_Hs578T_Human1.16590092
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.14264719
100SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.14003946
101BCL6_27268052_Chip-Seq_Bcells_Human1.13767729
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13404836
103SPI1_23127762_ChIP-Seq_K562_Human1.13303350
104* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11483273
105ZNF263_19887448_ChIP-Seq_K562_Human1.11060686
106* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10626321
107* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10435302
108* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10292467
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.10141217
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.09518641
111* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09483272
112SPI1_20517297_ChIP-Seq_HL60_Human1.08894677
113ATF3_27146783_Chip-Seq_COLON_Human1.08013384
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06218592
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04740118
116ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04326072
117NANOG_21062744_ChIP-ChIP_HESCs_Human1.03580045
118TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03431738
119* P300_27268052_Chip-Seq_Bcells_Human1.03198462
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02959451
121FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02702862
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02241941
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00887016
124PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00377598
125TP63_19390658_ChIP-ChIP_HaCaT_Human1.00014470
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99584579
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98140084
128VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98055329
129* CTCF_20526341_ChIP-Seq_ESCs_Human0.98027242
130NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97995728
131TFEB_21752829_ChIP-Seq_HELA_Human0.97473481
132* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97314497
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96474447
134CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95483102
135POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94882457
136GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93696350
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93687414
138RUNX_20019798_ChIP-Seq_JUKART_Human0.93497591
139STAT1_20625510_ChIP-Seq_HELA_Human0.92653980
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92263084
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92131285
142* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92031962
143NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91559695
144CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91120478
145* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90903074
146RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90539941
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90179345
148BCOR_27268052_Chip-Seq_Bcells_Human0.89817927
149IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89689651
150FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89391854
151P68_20966046_ChIP-Seq_HELA_Human0.88490673
152TP53_22127205_ChIP-Seq_IMR90_Human0.87531917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.61717548
2MP0002138_abnormal_hepatobiliary_system3.49353668
3MP0009278_abnormal_bone_marrow3.43839092
4MP0008057_abnormal_DNA_replication2.65177689
5MP0005646_abnormal_pituitary_gland2.65112085
6MP0010352_gastrointestinal_tract_polyps2.55474709
7MP0002148_abnormal_hypersensitivity_rea2.54815536
8MP0005076_abnormal_cell_differentiation2.28688974
9MP0004885_abnormal_endolymph2.19214888
10MP0001545_abnormal_hematopoietic_system2.12332234
11MP0005397_hematopoietic_system_phenotyp2.12332234
12MP0003705_abnormal_hypodermis_morpholog2.10863851
13MP0000685_abnormal_immune_system2.02311562
14MP0002396_abnormal_hematopoietic_system2.01191068
15MP0004782_abnormal_surfactant_physiolog2.00882572
16MP0001533_abnormal_skeleton_physiology1.97276932
17MP0003566_abnormal_cell_adhesion1.93747310
18MP0005670_abnormal_white_adipose1.80802334
19MP0009780_abnormal_chondrocyte_physiolo1.80177642
20MP0000467_abnormal_esophagus_morphology1.79321271
21MP0002166_altered_tumor_susceptibility1.75464717
22MP0003300_gastrointestinal_ulcer1.70335165
23MP0001851_eye_inflammation1.66263350
24MP0003303_peritoneal_inflammation1.64294442
25MP0000490_abnormal_crypts_of1.59363299
26MP0009053_abnormal_anal_canal1.59234391
27MP0003453_abnormal_keratinocyte_physiol1.58969681
28MP0002009_preneoplasia1.58795513
29MP0004808_abnormal_hematopoietic_stem1.56525779
30MP0002405_respiratory_system_inflammati1.55444112
31MP0003828_pulmonary_edema1.54947896
32MP0010094_abnormal_chromosome_stability1.53474772
33MP0004130_abnormal_muscle_cell1.53338691
34MP0002876_abnormal_thyroid_physiology1.51313369
35MP0005023_abnormal_wound_healing1.51291647
36MP0003283_abnormal_digestive_organ1.46068769
37MP0003763_abnormal_thymus_physiology1.45161640
38MP0001835_abnormal_antigen_presentation1.44985732
39MP0009333_abnormal_splenocyte_physiolog1.43220195
40MP0001800_abnormal_humoral_immune1.43177280
41MP0000383_abnormal_hair_follicle1.43006301
42MP0010307_abnormal_tumor_latency1.40939544
43MP0003436_decreased_susceptibility_to1.39617531
44MP0006082_CNS_inflammation1.39368589
45MP0002398_abnormal_bone_marrow1.38058874
46MP0003111_abnormal_nucleus_morphology1.36422164
47MP0003077_abnormal_cell_cycle1.36413531
48MP0010030_abnormal_orbit_morphology1.35849042
49MP0004957_abnormal_blastocyst_morpholog1.34666418
50MP0002006_tumorigenesis1.34428554
51MP0005387_immune_system_phenotype1.30572244
52MP0001790_abnormal_immune_system1.30572244
53MP0010155_abnormal_intestine_physiology1.30446329
54MP0000689_abnormal_spleen_morphology1.30404550
55* MP0002086_abnormal_extraembryonic_tissu1.29982846
56MP0002452_abnormal_antigen_presenting1.29513919
57MP0005058_abnormal_lysosome_morphology1.23351898
58MP0002722_abnormal_immune_system1.22867939
59MP0009785_altered_susceptibility_to1.22589965
60MP0003693_abnormal_embryo_hatching1.22530217
61MP0008438_abnormal_cutaneous_collagen1.22310639
62MP0000350_abnormal_cell_proliferation1.18898539
63MP0003045_fibrosis1.18001896
64MP0000703_abnormal_thymus_morphology1.17471897
65MP0009764_decreased_sensitivity_to1.17283000
66MP0003191_abnormal_cellular_cholesterol1.16558822
67MP0003279_aneurysm1.16193707
68MP0002060_abnormal_skin_morphology1.14863934
69MP0001663_abnormal_digestive_system1.14467786
70MP0002420_abnormal_adaptive_immunity1.14015869
71MP0004185_abnormal_adipocyte_glucose1.13742712
72MP0005390_skeleton_phenotype1.13724955
73MP0001819_abnormal_immune_cell1.13395905
74MP0004197_abnormal_fetal_growth/weight/1.13155795
75MP0000716_abnormal_immune_system1.13120592
76MP0003448_altered_tumor_morphology1.12496680
77MP0002019_abnormal_tumor_incidence1.11982111
78MP0005464_abnormal_platelet_physiology1.11840776
79MP0008004_abnormal_stomach_pH1.10890379
80MP0004947_skin_inflammation1.10584676
81MP0003567_abnormal_fetal_cardiomyocyte1.07909014
82MP0002723_abnormal_immune_serum1.07534380
83MP0001873_stomach_inflammation1.07159222
84* MP0001672_abnormal_embryogenesis/_devel1.06651421
85* MP0005380_embryogenesis_phenotype1.06651421
86MP0005174_abnormal_tail_pigmentation1.04247674
87* MP0003984_embryonic_growth_retardation1.04158767
88MP0002429_abnormal_blood_cell1.04093598
89MP0005000_abnormal_immune_tolerance1.03699185
90MP0003656_abnormal_erythrocyte_physiolo1.03619749
91MP0002877_abnormal_melanocyte_morpholog1.03354892
92* MP0001697_abnormal_embryo_size1.02920882
93MP0009765_abnormal_xenobiotic_induced1.02879339
94MP0005666_abnormal_adipose_tissue1.02510823
95* MP0002088_abnormal_embryonic_growth/wei1.02320365
96MP0000733_abnormal_muscle_development1.02310383
97MP0005671_abnormal_response_to1.02297132
98MP0000613_abnormal_salivary_gland1.01328723
99MP0002998_abnormal_bone_remodeling1.01301474
100MP0005220_abnormal_exocrine_pancreas0.99793834
101MP0002084_abnormal_developmental_patter0.99708643
102MP0001849_ear_inflammation0.99564634
103MP0004264_abnormal_extraembryonic_tissu0.99017025
104MP0005025_abnormal_response_to0.98706984
105MP0009379_abnormal_foot_pigmentation0.98486581
106MP0001661_extended_life_span0.96030700
107MP0001730_embryonic_growth_arrest0.95855204
108MP0000015_abnormal_ear_pigmentation0.95732788
109MP0003091_abnormal_cell_migration0.95272401
110* MP0002085_abnormal_embryonic_tissue0.94616901
111MP0010678_abnormal_skin_adnexa0.94521360
112MP0004233_abnormal_muscle_weight0.92660356
113MP0002419_abnormal_innate_immunity0.91670457
114MP0000681_abnormal_thyroid_gland0.91605689
115MP0000537_abnormal_urethra_morphology0.90860107
116MP0000767_abnormal_smooth_muscle0.90420386
117MP0006054_spinal_hemorrhage0.89794217
118MP0000858_altered_metastatic_potential0.89596869
119* MP0002925_abnormal_cardiovascular_devel0.89328134
120MP0005083_abnormal_biliary_tract0.89254951
121MP0008775_abnormal_heart_ventricle0.88964814
122MP0002796_impaired_skin_barrier0.88931086
123MP0008058_abnormal_DNA_repair0.88521173
124MP0000343_altered_response_to0.88216764
125MP0001764_abnormal_homeostasis0.86667633
126MP0000465_gastrointestinal_hemorrhage0.86486176
127MP0008007_abnormal_cellular_replicative0.84724262
128MP0005501_abnormal_skin_physiology0.82704090
129MP0002933_joint_inflammation0.82419213
130MP0008469_abnormal_protein_level0.82324401
131* MP0010630_abnormal_cardiac_muscle0.82318396
132MP0003172_abnormal_lysosome_physiology0.82030093
133MP0000477_abnormal_intestine_morphology0.81689898
134MP0009931_abnormal_skin_appearance0.80061909
135MP0005508_abnormal_skeleton_morphology0.79932589
136MP0000371_diluted_coat_color0.79133688
137* MP0002080_prenatal_lethality0.79132827
138MP0001845_abnormal_inflammatory_respons0.78667606
139MP0009643_abnormal_urine_homeostasis0.78543084
140MP0004883_abnormal_blood_vessel0.78390697
141MP0000313_abnormal_cell_death0.77990921
142MP0000230_abnormal_systemic_arterial0.76581255
143MP0002132_abnormal_respiratory_system0.76410718
144MP0001853_heart_inflammation0.76180882
145MP0003806_abnormal_nucleotide_metabolis0.76110074
146MP0005381_digestive/alimentary_phenotyp0.74831327
147MP0002254_reproductive_system_inflammat0.74246844
148MP0003638_abnormal_response/metabolism_0.73849146
149MP0005164_abnormal_response_to0.72936566
150MP0002282_abnormal_trachea_morphology0.72307576
151MP0003646_muscle_fatigue0.71207782
152MP0003183_abnormal_peptide_metabolism0.71045479
153MP0005409_darkened_coat_color0.70603707
154MP0003786_premature_aging0.69403030
155MP0005310_abnormal_salivary_gland0.69216278

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)4.01083481
2Cerebral aneurysm (HP:0004944)3.78496707
3Abnormality of the proximal phalanges of the hand (HP:0009834)3.66249888
4Elevated erythrocyte sedimentation rate (HP:0003565)3.56392167
5Ulnar bowing (HP:0003031)3.46306660
6Abnormality of the columella (HP:0009929)3.32595036
7Abnormality of the prostate (HP:0008775)3.31539237
8Autoimmune hemolytic anemia (HP:0001890)3.26697914
9Abnormality of the nasal septum (HP:0000419)3.07794273
10Rib fusion (HP:0000902)2.94623287
11Abnormality of the distal phalanges of the toes (HP:0010182)2.87253861
12Thrombocytosis (HP:0001894)2.87155487
13Morphological abnormality of the middle ear (HP:0008609)2.84642220
14Stomach cancer (HP:0012126)2.83179254
15Agammaglobulinemia (HP:0004432)2.82229266
16Abnormality of the heme biosynthetic pathway (HP:0010472)2.77473393
17Abnormal number of erythroid precursors (HP:0012131)2.75128633
18Prostate neoplasm (HP:0100787)2.69007690
19Hyperthyroidism (HP:0000836)2.67799826
20Abnormality of cells of the erythroid lineage (HP:0012130)2.66643845
21Abnormality of B cell number (HP:0010975)2.59992755
22Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.58900441
23Short 1st metacarpal (HP:0010034)2.58900441
24Intestinal fistula (HP:0100819)2.57934502
25Meningitis (HP:0001287)2.57920094
26Abnormality of glycolipid metabolism (HP:0010969)2.57161167
27Abnormality of liposaccharide metabolism (HP:0010968)2.57161167
28Abnormality of glycosphingolipid metabolism (HP:0004343)2.57161167
29Mediastinal lymphadenopathy (HP:0100721)2.55236261
30Alopecia of scalp (HP:0002293)2.54126596
31Acute lymphatic leukemia (HP:0006721)2.53803633
32Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.51516360
33Chronic obstructive pulmonary disease (HP:0006510)2.51500780
34Obstructive lung disease (HP:0006536)2.51500780
35Poikiloderma (HP:0001029)2.51471990
36B lymphocytopenia (HP:0010976)2.50043833
37Stomatitis (HP:0010280)2.48632343
38Abnormality of the fingertips (HP:0001211)2.46230361
39Cellulitis (HP:0100658)2.44088263
40Colitis (HP:0002583)2.40166882
41Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.37664150
42Asplenia (HP:0001746)2.37141920
43Recurrent fungal infections (HP:0002841)2.36476965
44Entropion (HP:0000621)2.36227207
45Granulocytopenia (HP:0001913)2.35770176
46Facial hemangioma (HP:0000329)2.35306954
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.32992681
48Epistaxis (HP:0000421)2.30463210
49Basal cell carcinoma (HP:0002671)2.29256820
50Abnormality of the 1st metacarpal (HP:0010009)2.28587875
51Thyroid-stimulating hormone excess (HP:0002925)2.26131829
52Recurrent cutaneous fungal infections (HP:0011370)2.25539663
53Chronic mucocutaneous candidiasis (HP:0002728)2.25539663
54Urinary glycosaminoglycan excretion (HP:0003541)2.25510348
55Mucopolysacchariduria (HP:0008155)2.25510348
56Rectovaginal fistula (HP:0000143)2.22216270
57Rectal fistula (HP:0100590)2.22216270
58Short humerus (HP:0005792)2.21752376
59Abnormality of the costochondral junction (HP:0000919)2.21285603
60Hypoplasia of the odontoid process (HP:0003311)2.20517767
61Spontaneous hematomas (HP:0007420)2.20209355
62Inflammation of the large intestine (HP:0002037)2.20207917
63Eczematoid dermatitis (HP:0000976)2.20202653
64Gastrointestinal inflammation (HP:0004386)2.19688959
65Dysostosis multiplex (HP:0000943)2.19101173
66Polycythemia (HP:0001901)2.18825565
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.18584825
68Protrusio acetabuli (HP:0003179)2.18298835
69Recurrent viral infections (HP:0004429)2.18094015
70Chest pain (HP:0100749)2.16564539
71IgG deficiency (HP:0004315)2.16459678
72Vertebral hypoplasia (HP:0008417)2.15438236
73Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.15438236
74Conjunctival hamartoma (HP:0100780)2.14691554
75Selective tooth agenesis (HP:0001592)2.13276126
76Annular pancreas (HP:0001734)2.11171019
77Abnormality of the phalanges of the 5th finger (HP:0004213)2.10897001
78IgA deficiency (HP:0002720)2.09498562
79Hypochromic anemia (HP:0001931)2.08489597
80Abnormality of the middle phalanges of the toes (HP:0010183)2.08176046
81Bilateral microphthalmos (HP:0007633)2.06321996
82Volvulus (HP:0002580)2.05570855
83Abnormality of polysaccharide metabolism (HP:0011012)2.05165887
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05165887
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05165887
86Hypochromic microcytic anemia (HP:0004840)2.04818488
87Aplasia/hypoplasia of the humerus (HP:0006507)2.04535214
88Short femoral neck (HP:0100864)2.04487527
89Vasculitis (HP:0002633)2.04196332
90Arterial thrombosis (HP:0004420)2.03818396
91Long nose (HP:0003189)2.03549114
92Myocardial infarction (HP:0001658)2.03286276
93Truncus arteriosus (HP:0001660)2.03221363
94Chronic otitis media (HP:0000389)2.03003426
95Short hallux (HP:0010109)2.02353034
96Abnormality of male internal genitalia (HP:0000022)2.01683533
97Hematochezia (HP:0002573)2.00048082
98Vaginal fistula (HP:0004320)1.99922654
99Abnormality of DNA repair (HP:0003254)1.99568391
100Recurrent abscess formation (HP:0002722)1.99425383
101Urethral obstruction (HP:0000796)1.99399640
102Cutaneous melanoma (HP:0012056)1.98184295
103Bowing of the arm (HP:0006488)1.98175907
104Bowed forearm bones (HP:0003956)1.98175907
105Aortic aneurysm (HP:0004942)1.97808449
106Premature skin wrinkling (HP:0100678)1.97802974
107Alveolar cell carcinoma (HP:0006519)1.97634734
108Joint stiffness (HP:0001387)1.97580029
109Abnormality of the odontoid process (HP:0003310)1.97154661
110Aplasia/Hypoplasia of the hallux (HP:0008362)1.96896355
111Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.96880446
112Polygenic inheritance (HP:0010982)1.94922357
113Microvesicular hepatic steatosis (HP:0001414)1.94868992
114Paralysis (HP:0003470)1.92566050
115Amaurosis fugax (HP:0100576)1.92139749
116Increased neuronal autofluorescent lipopigment (HP:0002074)1.91143999
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90661926
118Increased IgM level (HP:0003496)1.90409394
119Flared iliac wings (HP:0002869)1.87060160
120Spondylolisthesis (HP:0003302)1.87040858
121Abnormality of the nasal mucosa (HP:0000433)1.86801385
122Abolished electroretinogram (ERG) (HP:0000550)1.85982777
123Abnormality of T cell physiology (HP:0011840)1.85795185
124Pulmonary infiltrates (HP:0002113)1.85481165
125Abnormal hemoglobin (HP:0011902)1.85435713
126IgM deficiency (HP:0002850)1.85280793
127Abnormal platelet volume (HP:0011876)1.85234430
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.84139049
129Absent/shortened dynein arms (HP:0200106)1.84139049
130Eosinophilia (HP:0001880)1.83483335
131Orthostatic hypotension (HP:0001278)1.81772187
132Ankle contracture (HP:0006466)1.81100571
133Recurrent skin infections (HP:0001581)1.80661959
134Squamous cell carcinoma (HP:0002860)1.80432700
135Aplasia/hypoplasia of the femur (HP:0005613)1.80071235
136Short phalanx of the thumb (HP:0009660)1.79498025
137Carpal bone hypoplasia (HP:0001498)1.78876819
138Methylmalonic acidemia (HP:0002912)1.78614893
139Microcytic anemia (HP:0001935)1.77795938
140Autoimmune thrombocytopenia (HP:0001973)1.77476536
141Genu recurvatum (HP:0002816)1.75418962
142Muscle fibrillation (HP:0010546)1.75370525
143Mitral valve prolapse (HP:0001634)1.74266900
144Concave nail (HP:0001598)1.74146366
145Abnormality of T cells (HP:0002843)1.73961496
146Long eyelashes (HP:0000527)1.73617295
147Osteolytic defects of the hand bones (HP:0009699)1.72488780
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.72488780
149Male infertility (HP:0003251)1.71834034
150Cheilitis (HP:0100825)1.71215621
151Albinism (HP:0001022)1.70231441
152Spinal cord lesions (HP:0100561)1.69716089
153Syringomyelia (HP:0003396)1.69716089
154Short 4th metacarpal (HP:0010044)1.69194736
155Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69194736
156Nasal polyposis (HP:0100582)1.68175611
157Aneurysm (HP:0002617)1.68159596
158Shallow orbits (HP:0000586)1.67808214
159Bicuspid aortic valve (HP:0001647)1.64555204
160Increased mean platelet volume (HP:0011877)1.64187125
161Congenital hip dislocation (HP:0001374)1.63139427
162Patellar aplasia (HP:0006443)1.62910060
163Broad thumb (HP:0011304)1.61960903
164Tongue fasciculations (HP:0001308)1.61918901
165Premature rupture of membranes (HP:0001788)1.61613845
166Aortic dissection (HP:0002647)1.61183860
167Lip pit (HP:0100267)1.60808209
168Recurrent bacterial skin infections (HP:0005406)1.59949730
169Vertebral fusion (HP:0002948)1.59609934
170Papilloma (HP:0012740)1.59508225
171Verrucae (HP:0200043)1.59508225
172Short 5th finger (HP:0009237)1.59499322
173Asymmetric septal hypertrophy (HP:0001670)1.59438029
174Increased density of long bones (HP:0006392)1.58952768
175Increased connective tissue (HP:0009025)1.58475660
176Myositis (HP:0100614)1.55982936
177Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.55434988
178Panhypogammaglobulinemia (HP:0003139)1.55167825
179Prolonged bleeding time (HP:0003010)1.55041987
180Deviation of the thumb (HP:0009603)1.54396414
181Increased IgE level (HP:0003212)1.54248664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.17130088
2TEC3.38043485
3ICK3.31691822
4CDK123.01392678
5MAP3K102.91764051
6EEF2K2.56992172
7MAP4K12.53825807
8DDR22.45925014
9TRIB32.37383984
10MAPK152.26542885
11STK162.17218224
12STK102.12267024
13ERN12.10326292
14MAP3K62.09309201
15TGFBR21.95258517
16SYK1.94341875
17CSK1.93221944
18MATK1.92278460
19PLK41.88794863
20MAP3K111.75784160
21BMX1.70955545
22TRPM71.70831439
23FES1.70035713
24PIM21.70020961
25PIM11.64681378
26CDK61.64119768
27TNK21.63853043
28EIF2AK31.63292710
29PDGFRA1.59529919
30TLK11.55307743
31KSR21.52856054
32TXK1.51527120
33PKN21.48109116
34IKBKE1.46786159
35CDK71.46379094
36NME11.45670973
37FGR1.43965601
38PRKD21.43115338
39TYRO31.39215700
40RPS6KB21.28164836
41IRAK31.26367080
42DYRK1B1.22132511
43RIPK11.21804775
44EPHB11.21628064
45TESK21.19912583
46NEK21.15882458
47GRK11.14773355
48TYK21.13753131
49PAK41.12767160
50CSF1R1.10616678
51LRRK21.10398647
52BMPR21.09595616
53IRAK41.09043596
54TTN1.08493786
55ZAP701.08309254
56MTOR1.08232635
57JAK31.06198556
58GRK61.05672593
59STK31.04697770
60PRPF4B1.03541850
61EIF2AK11.02232027
62CDK41.01868609
63MAP2K20.96721812
64PTK60.92082443
65CAMK1D0.92067206
66MAPKAPK30.91911686
67CHUK0.90607280
68ADRBK20.90355555
69EPHA20.90016068
70BLK0.89968470
71RPS6KC10.87918711
72RPS6KL10.87918711
73BTK0.87872338
74STK40.87442872
75RAF10.87129655
76MAPK110.86207143
77MAP2K30.85982910
78RPS6KA60.84821557
79DMPK0.84104167
80RPS6KA40.83987616
81SIK10.83095847
82YES10.82522501
83IKBKB0.81241578
84LATS10.77712739
85IRAK10.77648160
86HIPK20.77300108
87RPS6KA20.76677170
88TBK10.76160815
89MAP3K140.75472298
90SMG10.75342364
91MAPK70.71652942
92PDGFRB0.70689544
93MAP3K80.70625785
94CDC70.69601055
95LCK0.67814818
96GSK3A0.66907992
97NME20.66776264
98FLT30.66607188
99MAP3K20.66310407
100HCK0.66287290
101PAK20.65722498
102NUAK10.65600103
103TAOK10.65353529
104NEK90.65097323
105KIT0.64515351
106FGFR40.63916817
107KDR0.63891963
108ITK0.63316548
109PDK10.62983467
110MAPKAPK20.62510520
111MAP4K20.60885776
112FGFR30.59080239
113BCKDK0.58762508
114MAPKAPK50.58197115
115* MAPK30.58112396
116CLK10.57192947
117CDK90.57078404
118CHEK20.56826296
119RPS6KA10.56663545
120LYN0.56608734
121EGFR0.54863572
122GRK70.54577394
123MAP3K130.54408907
124MAP3K30.53152969
125ALK0.52008706
126JAK10.51977356
127ATR0.51849271
128TAOK30.50416997
129PTK2B0.50323364
130DYRK30.49105519
131MOS0.49013940
132MAP3K10.48709915
133JAK20.46657503
134RPS6KA50.46301475
135PIK3CG0.44225735
136BRD40.44202851
137PTK20.43450251
138AURKB0.43199504
139PRKCQ0.42608848
140TGFBR10.42590198
141MARK30.42171228
142MELK0.41778288
143CDC42BPA0.41481982
144CAMK1G0.40965573
145MAPK40.40159881
146TTK0.40006947
147DAPK10.38449339
148PDPK10.37787516
149* ABL10.36351463
150SIK30.32669174

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.91699748
2Allograft rejection_Homo sapiens_hsa053303.42821621
3Graft-versus-host disease_Homo sapiens_hsa053323.28993613
4Autoimmune thyroid disease_Homo sapiens_hsa053203.19650302
5Type I diabetes mellitus_Homo sapiens_hsa049402.59416985
6Base excision repair_Homo sapiens_hsa034102.30748289
7Mismatch repair_Homo sapiens_hsa034302.29096110
8DNA replication_Homo sapiens_hsa030302.17198469
9Primary immunodeficiency_Homo sapiens_hsa053402.14398345
10Notch signaling pathway_Homo sapiens_hsa043301.90774501
11Chronic myeloid leukemia_Homo sapiens_hsa052201.82502196
12B cell receptor signaling pathway_Homo sapiens_hsa046621.78098411
13Small cell lung cancer_Homo sapiens_hsa052221.62355851
14Transcriptional misregulation in cancer_Homo sapiens_hsa052021.59835712
15* Adherens junction_Homo sapiens_hsa045201.55620977
16Leishmaniasis_Homo sapiens_hsa051401.55198206
17p53 signaling pathway_Homo sapiens_hsa041151.53365412
18Acute myeloid leukemia_Homo sapiens_hsa052211.52202339
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.50214450
20Fatty acid biosynthesis_Homo sapiens_hsa000611.50021390
21Cell cycle_Homo sapiens_hsa041101.44549477
22Viral myocarditis_Homo sapiens_hsa054161.43320513
23Rheumatoid arthritis_Homo sapiens_hsa053231.42288966
24Osteoclast differentiation_Homo sapiens_hsa043801.41862253
25MicroRNAs in cancer_Homo sapiens_hsa052061.39188934
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.38498477
27RNA degradation_Homo sapiens_hsa030181.38376848
28Measles_Homo sapiens_hsa051621.38222654
29Herpes simplex infection_Homo sapiens_hsa051681.34764488
30mTOR signaling pathway_Homo sapiens_hsa041501.33140537
31Pancreatic cancer_Homo sapiens_hsa052121.28632622
32Antigen processing and presentation_Homo sapiens_hsa046121.28169835
33Spliceosome_Homo sapiens_hsa030401.23503718
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21986076
35Hepatitis B_Homo sapiens_hsa051611.21361227
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.21127919
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21057503
38Legionellosis_Homo sapiens_hsa051341.20708485
39Toxoplasmosis_Homo sapiens_hsa051451.20453479
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19718361
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17942509
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17095535
43* Shigellosis_Homo sapiens_hsa051311.17023963
44Lysine degradation_Homo sapiens_hsa003101.16305913
45Colorectal cancer_Homo sapiens_hsa052101.16300227
46RNA transport_Homo sapiens_hsa030131.15767888
47* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15433975
48TGF-beta signaling pathway_Homo sapiens_hsa043501.15287772
49* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15101904
50Viral carcinogenesis_Homo sapiens_hsa052031.14807900
51Apoptosis_Homo sapiens_hsa042101.13146394
52HTLV-I infection_Homo sapiens_hsa051661.13030252
53Bladder cancer_Homo sapiens_hsa052191.12503947
54Hematopoietic cell lineage_Homo sapiens_hsa046401.12298679
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11998052
56mRNA surveillance pathway_Homo sapiens_hsa030151.10182841
57Proteoglycans in cancer_Homo sapiens_hsa052051.09655912
58Focal adhesion_Homo sapiens_hsa045101.09139755
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07801568
60Hippo signaling pathway_Homo sapiens_hsa043901.07075099
61Staphylococcus aureus infection_Homo sapiens_hsa051501.04780258
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.04750347
63VEGF signaling pathway_Homo sapiens_hsa043701.03756685
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99291897
65Hepatitis C_Homo sapiens_hsa051600.98345373
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.97872204
67Homologous recombination_Homo sapiens_hsa034400.94806273
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94643603
69* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91135253
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89839647
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89783255
72Nucleotide excision repair_Homo sapiens_hsa034200.89607184
73Thyroid cancer_Homo sapiens_hsa052160.89316426
74Prostate cancer_Homo sapiens_hsa052150.89090689
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87774435
76Other glycan degradation_Homo sapiens_hsa005110.87632157
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86411378
78T cell receptor signaling pathway_Homo sapiens_hsa046600.85741941
79Platelet activation_Homo sapiens_hsa046110.85555541
80Glycerolipid metabolism_Homo sapiens_hsa005610.84387336
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83695033
82Epstein-Barr virus infection_Homo sapiens_hsa051690.83662348
83Pathways in cancer_Homo sapiens_hsa052000.82868873
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80859680
85Basal cell carcinoma_Homo sapiens_hsa052170.80820448
86TNF signaling pathway_Homo sapiens_hsa046680.79952037
87Influenza A_Homo sapiens_hsa051640.79464235
88Non-small cell lung cancer_Homo sapiens_hsa052230.79438508
89Malaria_Homo sapiens_hsa051440.79269315
90Fanconi anemia pathway_Homo sapiens_hsa034600.79015237
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77869859
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77802045
93ECM-receptor interaction_Homo sapiens_hsa045120.77172109
94Chemokine signaling pathway_Homo sapiens_hsa040620.76913525
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76503146
96Tuberculosis_Homo sapiens_hsa051520.75547334
97Hedgehog signaling pathway_Homo sapiens_hsa043400.74610514
98Arachidonic acid metabolism_Homo sapiens_hsa005900.73240292
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.73087689
100Systemic lupus erythematosus_Homo sapiens_hsa053220.71034190
101HIF-1 signaling pathway_Homo sapiens_hsa040660.70534004
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70031309
103Amoebiasis_Homo sapiens_hsa051460.69567703
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67963624
105Endometrial cancer_Homo sapiens_hsa052130.67677480
106Pertussis_Homo sapiens_hsa051330.67640447
107Dorso-ventral axis formation_Homo sapiens_hsa043200.67610762
108Lysosome_Homo sapiens_hsa041420.65832670
109Ribosome_Homo sapiens_hsa030100.64865230
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64116516
111Insulin resistance_Homo sapiens_hsa049310.61012669
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60443774
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.60320530
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60258552
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58686400
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58423574
117One carbon pool by folate_Homo sapiens_hsa006700.57515185
118FoxO signaling pathway_Homo sapiens_hsa040680.57268901
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56246361
120Type II diabetes mellitus_Homo sapiens_hsa049300.55924893
121Endocytosis_Homo sapiens_hsa041440.54908578
122Prolactin signaling pathway_Homo sapiens_hsa049170.54121675
123Non-homologous end-joining_Homo sapiens_hsa034500.53418610
124Renal cell carcinoma_Homo sapiens_hsa052110.53174234
125African trypanosomiasis_Homo sapiens_hsa051430.49210811
126Renin-angiotensin system_Homo sapiens_hsa046140.46837604
127Nitrogen metabolism_Homo sapiens_hsa009100.40096289
128Phagosome_Homo sapiens_hsa041450.37258102
129Olfactory transduction_Homo sapiens_hsa047400.34489292
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32350406
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32242283
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.30229845
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.26861755
134Melanoma_Homo sapiens_hsa052180.25592750
135* Choline metabolism in cancer_Homo sapiens_hsa052310.25446403
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25371898
137Linoleic acid metabolism_Homo sapiens_hsa005910.24272427

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