WASH2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.08162059
2negative regulation of cell killing (GO:0031342)5.08162059
3negative regulation of erythrocyte differentiation (GO:0045647)5.00504242
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.81658156
5positive regulation of gamma-delta T cell activation (GO:0046645)4.80915866
6antigen processing and presentation of endogenous antigen (GO:0019883)4.60683119
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.57521821
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.43817742
9mannose metabolic process (GO:0006013)4.26663232
10detection of bacterium (GO:0016045)4.03127782
11detection of other organism (GO:0098543)3.92032257
12response to muramyl dipeptide (GO:0032495)3.89819940
13regulation of gamma-delta T cell activation (GO:0046643)3.82719078
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.74741753
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.74741753
16modulation by symbiont of host immune response (GO:0052553)3.74741753
17positive regulation by symbiont of host defense response (GO:0052509)3.74741753
18modulation by symbiont of host defense response (GO:0052031)3.74741753
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.74741753
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62608869
21* Arp2/3 complex-mediated actin nucleation (GO:0034314)3.57899158
22positive thymic T cell selection (GO:0045059)3.57840616
23response to peptidoglycan (GO:0032494)3.57047607
24regulation of gamma-delta T cell differentiation (GO:0045586)3.56010857
25thymic T cell selection (GO:0045061)3.55948054
26germinal center formation (GO:0002467)3.55088466
27NIK/NF-kappaB signaling (GO:0038061)3.45652576
28macrophage activation involved in immune response (GO:0002281)3.44785494
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40289800
30regulation of ARF GTPase activity (GO:0032312)3.36669531
31regulation of B cell receptor signaling pathway (GO:0050855)3.30548948
32negative thymic T cell selection (GO:0045060)3.30032696
33neutrophil activation involved in immune response (GO:0002283)3.24236234
34detection of external biotic stimulus (GO:0098581)3.22767918
35leukocyte aggregation (GO:0070486)3.21306383
36T cell selection (GO:0045058)3.12877947
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.12236877
38regulation of mast cell degranulation (GO:0043304)3.10376380
39immunoglobulin mediated immune response (GO:0016064)3.07205890
40B cell receptor signaling pathway (GO:0050853)3.05813650
41regulation of interferon-beta biosynthetic process (GO:0045357)3.05108007
42negative T cell selection (GO:0043383)3.04568121
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.02705606
44regulation of myeloid leukocyte mediated immunity (GO:0002886)2.98608260
45negative regulation of leukocyte mediated immunity (GO:0002704)2.95298017
46regulation of T-helper 2 cell differentiation (GO:0045628)2.93596596
47regulation of leukocyte degranulation (GO:0043300)2.92559713
48negative regulation of interleukin-12 production (GO:0032695)2.92093752
49response to type I interferon (GO:0034340)2.90687682
50tolerance induction (GO:0002507)2.87792637
51type I interferon signaling pathway (GO:0060337)2.85501728
52cellular response to type I interferon (GO:0071357)2.85501728
53positive regulation of B cell differentiation (GO:0045579)2.85092079
54detection of biotic stimulus (GO:0009595)2.84234447
55negative regulation of innate immune response (GO:0045824)2.82661420
56regulation of necroptotic process (GO:0060544)2.80255896
57regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80095725
58response to interleukin-15 (GO:0070672)2.77092607
59* actin nucleation (GO:0045010)2.76568746
60regulation of mast cell activation involved in immune response (GO:0033006)2.73243131
61positive regulation of histone deacetylation (GO:0031065)2.70574618
62positive T cell selection (GO:0043368)2.70401721
63neutrophil activation (GO:0042119)2.69212179
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67855843
65histone H4 deacetylation (GO:0070933)2.66453903
66cellular extravasation (GO:0045123)2.64454474
67detection of molecule of bacterial origin (GO:0032490)2.62591829
68signal complex assembly (GO:0007172)2.62110430
69negative regulation of type 2 immune response (GO:0002829)2.61382356
70defense response to protozoan (GO:0042832)2.60796134
71regulation of T cell tolerance induction (GO:0002664)2.60497017
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.59866040
73regulation of type I interferon-mediated signaling pathway (GO:0060338)2.59473630
74regulation of natural killer cell mediated immunity (GO:0002715)2.58654308
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.58654308
76granulocyte activation (GO:0036230)2.58427017
77negative regulation of T cell mediated immunity (GO:0002710)2.57535080
78positive regulation of Cdc42 GTPase activity (GO:0043089)2.56764321
79lipopolysaccharide-mediated signaling pathway (GO:0031663)2.56733860
80antigen processing and presentation via MHC class Ib (GO:0002475)2.56237917
81cellular response to virus (GO:0098586)2.54018009
82regulation of B cell differentiation (GO:0045577)2.52698154
83response to host immune response (GO:0052572)2.51208910
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51208910
85negative regulation of toll-like receptor signaling pathway (GO:0034122)2.50275057
86myeloid cell activation involved in immune response (GO:0002275)2.48465513
87interferon-gamma-mediated signaling pathway (GO:0060333)2.47571271
88regulation of regulated secretory pathway (GO:1903305)2.47344646
89regulation of antigen processing and presentation (GO:0002577)2.45278117
90regulation of tolerance induction (GO:0002643)2.44566404
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.43684301
92response to protozoan (GO:0001562)2.43639450
93histone H3 deacetylation (GO:0070932)2.43535716
94positive regulation of Rap GTPase activity (GO:0032854)2.43157580
95negative regulation of granulocyte differentiation (GO:0030853)2.43039427
96response to host (GO:0075136)2.42617247
97response to host defenses (GO:0052200)2.42617247
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.42617247
99respiratory burst (GO:0045730)2.41928957
100regulation of ARF protein signal transduction (GO:0032012)2.39719259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.20916517
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.90118090
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.87041686
4MYC_22102868_ChIP-Seq_BL_Human2.81353448
5LXR_22292898_ChIP-Seq_THP-1_Human2.75590835
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.70727945
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.48591006
8TCF7_22412390_ChIP-Seq_EML_Mouse2.40595626
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.39080336
10KDM2B_26808549_Chip-Seq_DND41_Human2.37609025
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27752078
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22079763
13VDR_24763502_ChIP-Seq_THP-1_Human2.17981140
14MAF_26560356_Chip-Seq_TH1_Human2.14266568
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.11985016
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.10987102
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09297562
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.07124603
19UTX_26944678_Chip-Seq_JUKART_Human1.98125971
20* MAF_26560356_Chip-Seq_TH2_Human1.93900637
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91013778
22RUNX1_22412390_ChIP-Seq_EML_Mouse1.88438665
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87204202
24RACK7_27058665_Chip-Seq_MCF-7_Human1.83573308
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83523254
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83300094
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82654745
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80156776
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79229768
30P68_20966046_ChIP-Seq_HELA_Human1.75854349
31SCL_19346495_ChIP-Seq_HPC-7_Human1.73790004
32* SPI1_23127762_ChIP-Seq_K562_Human1.72510356
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69189122
34KDM2B_26808549_Chip-Seq_K562_Human1.68524315
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67581252
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.66564023
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.66238163
38* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63799243
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62782157
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.62045976
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58968875
42BCL6_27268052_Chip-Seq_Bcells_Human1.58566591
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.57162279
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.55922734
45BCOR_27268052_Chip-Seq_Bcells_Human1.54404247
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.49956065
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49574186
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49373904
49SMC4_20622854_ChIP-Seq_HELA_Human1.49254424
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.48959608
51NCOR1_26117541_ChIP-Seq_K562_Human1.46438319
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46180779
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45125134
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45100988
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44674535
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.43881544
57GATA1_19941826_ChIP-Seq_K562_Human1.42676481
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41025191
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36945613
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36510830
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.36452169
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35475856
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33631493
64SPI1_23547873_ChIP-Seq_NB4_Human1.33018273
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32960112
66RUNX_20019798_ChIP-Seq_JUKART_Human1.32474570
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32337330
68CREB1_26743006_Chip-Seq_LNCaP_Human1.32045507
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31472580
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27205148
71MYB_26560356_Chip-Seq_TH1_Human1.24651355
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24563579
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.22648019
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22627532
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.21527566
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20081136
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19978535
78MYB_26560356_Chip-Seq_TH2_Human1.19941319
79DROSHA_22980978_ChIP-Seq_HELA_Human1.19870349
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18415783
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18377193
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17788391
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16253840
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16098498
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15023931
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14674517
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14277105
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13787450
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12680754
90PHF8_20622854_ChIP-Seq_HELA_Human1.11617991
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11616962
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10744586
93CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09946243
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09808894
95E2F1_20622854_ChIP-Seq_HELA_Human1.09760491
96SA1_27219007_Chip-Seq_Bcells_Human1.09706385
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09529768
98* RUNX1_27514584_Chip-Seq_MCF-7_Human1.09437970
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.07589287
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06048205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.14700429
2MP0003303_peritoneal_inflammation3.46202258
3MP0003724_increased_susceptibility_to3.17735121
4MP0005058_abnormal_lysosome_morphology3.09949305
5MP0003172_abnormal_lysosome_physiology2.93477797
6MP0001835_abnormal_antigen_presentation2.71991861
7MP0008260_abnormal_autophagy2.55897865
8MP0002419_abnormal_innate_immunity2.50156635
9MP0005025_abnormal_response_to2.48769087
10MP0000685_abnormal_immune_system2.48124160
11MP0001800_abnormal_humoral_immune2.43843960
12MP0001790_abnormal_immune_system2.42810110
13MP0005387_immune_system_phenotype2.42810110
14MP0005000_abnormal_immune_tolerance2.42794977
15MP0005671_abnormal_response_to2.41340827
16MP0009278_abnormal_bone_marrow2.39098525
17MP0005451_abnormal_body_composition2.23676259
18MP0003763_abnormal_thymus_physiology2.22981748
19MP0004947_skin_inflammation2.21012074
20MP0002723_abnormal_immune_serum2.19457447
21MP0002420_abnormal_adaptive_immunity2.10461465
22MP0001819_abnormal_immune_cell2.10329939
23MP0002452_abnormal_antigen_presenting2.08772020
24MP0003300_gastrointestinal_ulcer2.08213717
25MP0003191_abnormal_cellular_cholesterol2.06717095
26MP0009785_altered_susceptibility_to1.99371940
27MP0010155_abnormal_intestine_physiology1.92644642
28MP0001533_abnormal_skeleton_physiology1.86907279
29MP0003705_abnormal_hypodermis_morpholog1.86474988
30MP0005464_abnormal_platelet_physiology1.83109158
31MP0002405_respiratory_system_inflammati1.80461940
32MP0002398_abnormal_bone_marrow1.74959985
33MP0009840_abnormal_foam_cell1.71122318
34MP0002148_abnormal_hypersensitivity_rea1.67629592
35MP0006082_CNS_inflammation1.67527027
36MP0009333_abnormal_splenocyte_physiolog1.66324991
37MP0000716_abnormal_immune_system1.65690026
38MP0005076_abnormal_cell_differentiation1.56755523
39MP0001873_stomach_inflammation1.53923045
40MP0004510_myositis1.52202247
41MP0003866_abnormal_defecation1.50568852
42MP0001849_ear_inflammation1.49940280
43MP0001545_abnormal_hematopoietic_system1.49663203
44MP0005397_hematopoietic_system_phenotyp1.49663203
45MP0003183_abnormal_peptide_metabolism1.46452148
46MP0002396_abnormal_hematopoietic_system1.46450383
47MP0002933_joint_inflammation1.46389697
48MP0001845_abnormal_inflammatory_respons1.44280440
49MP0004381_abnormal_hair_follicle1.41306964
50MP0002722_abnormal_immune_system1.39615985
51MP0000858_altered_metastatic_potential1.39446417
52MP0000465_gastrointestinal_hemorrhage1.39185306
53MP0002429_abnormal_blood_cell1.37977419
54MP0002998_abnormal_bone_remodeling1.37045835
55MP0003656_abnormal_erythrocyte_physiolo1.36946801
56MP0004858_abnormal_nervous_system1.35040533
57MP0000689_abnormal_spleen_morphology1.34236777
58MP0002132_abnormal_respiratory_system1.33989966
59MP0000703_abnormal_thymus_morphology1.33482059
60MP0003828_pulmonary_edema1.31993761
61MP0008469_abnormal_protein_level1.19642562
62MP0005310_abnormal_salivary_gland1.08317114
63MP0003329_amyloid_beta_deposits1.07856426
64MP0000604_amyloidosis1.06202560
65MP0003690_abnormal_glial_cell1.05773953
66MP0003453_abnormal_keratinocyte_physiol1.05687649
67MP0003279_aneurysm1.05290501
68MP0009764_decreased_sensitivity_to1.02768527
69MP0000678_abnormal_parathyroid_gland0.99107011
70MP0005083_abnormal_biliary_tract0.98095234
71MP0001851_eye_inflammation0.96792575
72MP0001348_abnormal_lacrimal_gland0.96616688
73MP0003091_abnormal_cell_migration0.93686640
74MP0005409_darkened_coat_color0.93460228
75MP0005390_skeleton_phenotype0.91535710
76MP0003075_altered_response_to0.89961264
77MP0005360_urolithiasis0.87996543
78MP0001663_abnormal_digestive_system0.87082748
79MP0002166_altered_tumor_susceptibility0.86452432
80MP0001958_emphysema0.86038779
81MP0008874_decreased_physiological_sensi0.78541559
82MP0003795_abnormal_bone_structure0.78288221
83MP0003045_fibrosis0.76559324
84MP0005375_adipose_tissue_phenotype0.76410963
85MP0005666_abnormal_adipose_tissue0.75103840
86MP0004808_abnormal_hematopoietic_stem0.74130861
87MP0000249_abnormal_blood_vessel0.71804175
88MP0004185_abnormal_adipocyte_glucose0.71426844
89MP0002249_abnormal_larynx_morphology0.69975818
90MP0005166_decreased_susceptibility_to0.69639516
91MP0000003_abnormal_adipose_tissue0.69495701
92MP0009931_abnormal_skin_appearance0.69045591
93MP0003879_abnormal_hair_cell0.68158078
94MP0000609_abnormal_liver_physiology0.67785689
95MP0009763_increased_sensitivity_to0.63829181
96MP0008004_abnormal_stomach_pH0.63518002
97MP0002822_catalepsy0.63453242
98MP0004130_abnormal_muscle_cell0.61838513
99MP0001853_heart_inflammation0.61513246
100MP0001986_abnormal_taste_sensitivity0.61422456

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.92972618
2Recurrent abscess formation (HP:0002722)3.67833508
3Myositis (HP:0100614)3.66908180
4Recurrent bacterial skin infections (HP:0005406)3.62494444
5Abnormality of macrophages (HP:0004311)3.60239768
6Increased IgE level (HP:0003212)3.25783387
7Orchitis (HP:0100796)3.18542092
8Obstructive lung disease (HP:0006536)3.14694600
9Chronic obstructive pulmonary disease (HP:0006510)3.14694600
10Colitis (HP:0002583)3.09570926
11Obstructive sleep apnea (HP:0002870)3.06404222
12Mediastinal lymphadenopathy (HP:0100721)3.01695807
13Dysostosis multiplex (HP:0000943)2.97997050
14Broad face (HP:0000283)2.96022025
15Recurrent gram-negative bacterial infections (HP:0005420)2.93024208
16Recurrent fungal infections (HP:0002841)2.92299881
17Cellulitis (HP:0100658)2.92241714
18Gingivitis (HP:0000230)2.89758524
19Gastrointestinal infarctions (HP:0005244)2.86933389
20Meningitis (HP:0001287)2.85560291
21Pustule (HP:0200039)2.82249188
22Prolonged bleeding time (HP:0003010)2.82024569
23Thin bony cortex (HP:0002753)2.81332163
24Optic neuritis (HP:0100653)2.75112268
25Retrobulbar optic neuritis (HP:0100654)2.75112268
26Gastrointestinal inflammation (HP:0004386)2.74878519
27Hemorrhage of the eye (HP:0011885)2.73724438
28Elevated erythrocyte sedimentation rate (HP:0003565)2.64878571
29Inflammation of the large intestine (HP:0002037)2.61813204
30Spontaneous hematomas (HP:0007420)2.60596722
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.58982614
32Abnormality of polysaccharide metabolism (HP:0011012)2.56885984
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56885984
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56885984
35Urinary glycosaminoglycan excretion (HP:0003541)2.52802038
36Mucopolysacchariduria (HP:0008155)2.52802038
37Abnormality of the fingertips (HP:0001211)2.52416507
38Metaphyseal cupping (HP:0003021)2.50022326
39Malnutrition (HP:0004395)2.47742584
40Systemic lupus erythematosus (HP:0002725)2.45318864
41J-shaped sella turcica (HP:0002680)2.42978864
42Recurrent skin infections (HP:0001581)2.39192384
43Loss of speech (HP:0002371)2.38155394
44Vasculitis (HP:0002633)2.37971424
45Emphysema (HP:0002097)2.32779766
46Encephalitis (HP:0002383)2.31833180
47Increased cerebral lipofuscin (HP:0011813)2.31656847
48Epistaxis (HP:0000421)2.30010174
49Stomatitis (HP:0010280)2.27373805
50Panhypogammaglobulinemia (HP:0003139)2.27233893
51Recurrent viral infections (HP:0004429)2.26687013
52Cerebral aneurysm (HP:0004944)2.26124448
53Gastrointestinal stroma tumor (HP:0100723)2.25164505
54Chest pain (HP:0100749)2.24283784
55Recurrent cutaneous fungal infections (HP:0011370)2.22652571
56Chronic mucocutaneous candidiasis (HP:0002728)2.22652571
57Cervical subluxation (HP:0003308)2.19689642
58Purpura (HP:0000979)2.17998035
59Pulmonary infiltrates (HP:0002113)2.17800941
60Increased serum ferritin (HP:0003281)2.15528075
61Hypertensive crisis (HP:0100735)2.12543212
62Granulocytopenia (HP:0001913)2.10629032
63Reticulocytosis (HP:0001923)2.10112928
64Agammaglobulinemia (HP:0004432)2.08962102
65Hypochromic anemia (HP:0001931)2.08266551
66Easy fatigability (HP:0003388)2.07970977
67Keratoconjunctivitis sicca (HP:0001097)2.07633282
68Increased connective tissue (HP:0009025)2.06613081
69Premature loss of primary teeth (HP:0006323)2.04831996
70Hemoptysis (HP:0002105)2.04727996
71Distal lower limb amyotrophy (HP:0008944)2.03318461
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01277464
73Petechiae (HP:0000967)2.01012081
74Abnormality of liposaccharide metabolism (HP:0010968)1.99928795
75Abnormality of glycosphingolipid metabolism (HP:0004343)1.99928795
76Abnormality of glycolipid metabolism (HP:0010969)1.99928795
77Urticaria (HP:0001025)1.97376642
78Increased neuronal autofluorescent lipopigment (HP:0002074)1.97028321
79Stridor (HP:0010307)1.96617286
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95078977
81Restrictive lung disease (HP:0002091)1.93919312
82Hypertriglyceridemia (HP:0002155)1.92790194
83Segmental peripheral demyelination/remyelination (HP:0003481)1.92549116
84Centrally nucleated skeletal muscle fibers (HP:0003687)1.92537255
85Slow saccadic eye movements (HP:0000514)1.90625056
86Increased IgM level (HP:0003496)1.90456255
87Osteomyelitis (HP:0002754)1.89844567
88Abnormality of the nasal mucosa (HP:0000433)1.88010768
89Abnormality of the thoracic spine (HP:0100711)1.86749783
90Myopathic facies (HP:0002058)1.86600787
91Thoracic kyphosis (HP:0002942)1.86055384
92Neuronal loss in central nervous system (HP:0002529)1.85618007
93Keratoconjunctivitis (HP:0001096)1.83122125
94Polycythemia (HP:0001901)1.82423186
95Abnormality of the peritoneum (HP:0002585)1.82188505
96Seborrheic dermatitis (HP:0001051)1.81190491
97Joint stiffness (HP:0001387)1.80496294
98Interstitial pulmonary disease (HP:0006530)1.80275518
99Gastrointestinal dysmotility (HP:0002579)1.79478560
100Hypergammaglobulinemia (HP:0010702)1.79268129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.53481316
2TRIB33.39054491
3RIPK43.23149013
4MAP4K13.13474370
5PRPF4B2.62888990
6SIK12.41122841
7MAP2K32.30818216
8TNK22.21031780
9BLK1.97277200
10EPHB11.86023310
11TYK21.79444330
12ZAP701.76521358
13MAP3K131.72717546
14GRK61.72440018
15MARK21.70018109
16SIK21.68995145
17IRAK41.68319050
18TBK11.68244386
19MAP3K141.64121654
20FGFR41.57784367
21MAP3K111.56166555
22ICK1.53809444
23RIPK11.48140094
24FES1.44507067
25BTK1.43125079
26CSK1.42928516
27MAP3K71.42048961
28SMG11.41943750
29PRKD21.37465558
30TAOK11.37048714
31CDC42BPA1.36512454
32SIK31.33104607
33MAP3K61.29597985
34PKN21.27893714
35CDK121.23968519
36JAK31.16978554
37IKBKE1.16186157
38EEF2K1.12207082
39MAP3K31.11691301
40HCK1.09464855
41IRAK31.07081847
42MAP3K11.06894026
43PTK61.05945998
44SYK1.05036988
45TESK21.02238877
46MAP2K61.01765913
47BMX0.96794134
48TAOK20.95995049
49MAP2K20.94252796
50MAP3K100.94209270
51RPS6KA20.91507771
52KSR20.90050916
53RPS6KL10.89705945
54RPS6KC10.89705945
55FGR0.88662052
56MATK0.88058153
57CSF1R0.87654289
58JAK10.87344985
59KDR0.85600090
60MAPK150.84987120
61DYRK1B0.83547399
62MAPK120.82953190
63ITK0.82908222
64PDPK10.81895665
65LCK0.81241174
66IKBKB0.78559187
67LYN0.77867348
68TTN0.76617129
69HIPK20.75267062
70TXK0.74655648
71JAK20.74622697
72MAPK70.71609823
73RPS6KA60.71502183
74KIT0.70497695
75PDK10.69413268
76MST1R0.68030871
77CAMKK10.67922301
78RET0.67243794
79MARK30.61947822
80EPHA30.61777589
81FGFR30.56287391
82MAPK110.54308756
83MTOR0.51456949
84DDR20.49470644
85TAOK30.48090315
86FYN0.48001352
87PDGFRA0.46135837
88TYRO30.45952730
89CHUK0.45759227
90CDK40.45707163
91PRKD10.40828787
92MAPK40.39038467
93MAPKAPK20.37327923
94STK380.36643347
95MAPK30.35635485
96MAP2K40.34336289
97PDGFRB0.33564095
98ERBB20.33359942
99TESK10.32923735
100DAPK20.32733078

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.11378166
2Osteoclast differentiation_Homo sapiens_hsa043802.33393217
3Leishmaniasis_Homo sapiens_hsa051402.14257894
4B cell receptor signaling pathway_Homo sapiens_hsa046622.13593382
5Acute myeloid leukemia_Homo sapiens_hsa052211.98086027
6Staphylococcus aureus infection_Homo sapiens_hsa051501.96746787
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.85480355
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.83084970
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81266888
10Primary immunodeficiency_Homo sapiens_hsa053401.74360987
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73948777
12Allograft rejection_Homo sapiens_hsa053301.66791221
13Notch signaling pathway_Homo sapiens_hsa043301.65551351
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.63909784
15Graft-versus-host disease_Homo sapiens_hsa053321.60903164
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60622709
17T cell receptor signaling pathway_Homo sapiens_hsa046601.51348635
18Tuberculosis_Homo sapiens_hsa051521.49868838
19Autoimmune thyroid disease_Homo sapiens_hsa053201.49683875
20VEGF signaling pathway_Homo sapiens_hsa043701.49487700
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45164528
22Toxoplasmosis_Homo sapiens_hsa051451.40474252
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40328858
24TNF signaling pathway_Homo sapiens_hsa046681.38787464
25Chronic myeloid leukemia_Homo sapiens_hsa052201.32556557
26Non-small cell lung cancer_Homo sapiens_hsa052231.29794644
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28647815
28Influenza A_Homo sapiens_hsa051641.28476623
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27679938
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24163220
31Chemokine signaling pathway_Homo sapiens_hsa040621.22858060
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.21361026
33Malaria_Homo sapiens_hsa051441.20126860
34Measles_Homo sapiens_hsa051621.16504998
35Herpes simplex infection_Homo sapiens_hsa051681.14139516
36Hepatitis C_Homo sapiens_hsa051601.13553582
37Lysosome_Homo sapiens_hsa041421.10802528
38Hematopoietic cell lineage_Homo sapiens_hsa046401.10580296
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.09639884
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.08116107
41Viral myocarditis_Homo sapiens_hsa054161.07590558
42Antigen processing and presentation_Homo sapiens_hsa046121.06875541
43Type I diabetes mellitus_Homo sapiens_hsa049401.05662315
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.05190447
45Hepatitis B_Homo sapiens_hsa051611.03031090
46Choline metabolism in cancer_Homo sapiens_hsa052311.00837514
47Pertussis_Homo sapiens_hsa051331.00697867
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.00085270
49Pancreatic cancer_Homo sapiens_hsa052120.99625284
50Platelet activation_Homo sapiens_hsa046110.97863753
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96541437
52GnRH signaling pathway_Homo sapiens_hsa049120.95757985
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95500884
54Prolactin signaling pathway_Homo sapiens_hsa049170.94732099
55mTOR signaling pathway_Homo sapiens_hsa041500.94522106
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.91801902
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.91751401
58Endocytosis_Homo sapiens_hsa041440.89901525
59Asthma_Homo sapiens_hsa053100.89422203
60Apoptosis_Homo sapiens_hsa042100.88986439
61Shigellosis_Homo sapiens_hsa051310.88510147
62Salmonella infection_Homo sapiens_hsa051320.88378510
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85577760
64Fructose and mannose metabolism_Homo sapiens_hsa000510.82810408
65Phagosome_Homo sapiens_hsa041450.80291872
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.79307372
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78391976
68Insulin resistance_Homo sapiens_hsa049310.76991930
69Inositol phosphate metabolism_Homo sapiens_hsa005620.75087091
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73633792
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71721228
72Endometrial cancer_Homo sapiens_hsa052130.71016826
73ErbB signaling pathway_Homo sapiens_hsa040120.70729163
74Insulin signaling pathway_Homo sapiens_hsa049100.70584200
75Rheumatoid arthritis_Homo sapiens_hsa053230.69768374
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69750498
77Prion diseases_Homo sapiens_hsa050200.69425151
78Renal cell carcinoma_Homo sapiens_hsa052110.69054227
79African trypanosomiasis_Homo sapiens_hsa051430.68289344
80Bladder cancer_Homo sapiens_hsa052190.68055069
81Legionellosis_Homo sapiens_hsa051340.67054599
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66322747
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65009077
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64570590
85Estrogen signaling pathway_Homo sapiens_hsa049150.63993465
86Amoebiasis_Homo sapiens_hsa051460.62999116
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.62997953
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62674060
89HTLV-I infection_Homo sapiens_hsa051660.62222052
90MAPK signaling pathway_Homo sapiens_hsa040100.59903150
91Epstein-Barr virus infection_Homo sapiens_hsa051690.57201362
92Viral carcinogenesis_Homo sapiens_hsa052030.55856417
93Glioma_Homo sapiens_hsa052140.53298451
94ABC transporters_Homo sapiens_hsa020100.52992666
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52398915
96Type II diabetes mellitus_Homo sapiens_hsa049300.51165722
97Rap1 signaling pathway_Homo sapiens_hsa040150.46098249
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45130600
99Colorectal cancer_Homo sapiens_hsa052100.44481657
100HIF-1 signaling pathway_Homo sapiens_hsa040660.44477246

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