ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* Arp2/3 complex-mediated actin nucleation (GO:0034314)	7.77218069
2	* actin nucleation (GO:0045010)	6.38939009
3	negative regulation of telomere maintenance (GO:0032205)	5.90653037
4	positive regulation of B cell differentiation (GO:0045579)	5.72704375
5	sequestering of actin monomers (GO:0042989)	5.32589982
6	cytidine metabolic process (GO:0046087)	5.07022851
7	cytidine catabolic process (GO:0006216)	5.07022851
8	cytidine deamination (GO:0009972)	5.07022851
9	DNA deamination (GO:0045006)	4.94955036
10	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.76041412
11	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.75069307
12	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.38726605
13	base-excision repair, AP site formation (GO:0006285)	4.30608625
14	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.07166115
15	pyrimidine nucleotide catabolic process (GO:0006244)	4.03599077
16	deoxyribonucleotide catabolic process (GO:0009264)	3.85599718
17	regulation of telomere maintenance via telomerase (GO:0032210)	3.84945823
18	negative regulation of T cell apoptotic process (GO:0070233)	3.76890303
19	deoxyribose phosphate catabolic process (GO:0046386)	3.66299751
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.64465853
21	platelet dense granule organization (GO:0060155)	3.58944608
22	protein complex biogenesis (GO:0070271)	3.57646471
23	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.57485298
24	negative regulation of thymocyte apoptotic process (GO:0070244)	3.49378642
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.49142917
26	NADH dehydrogenase complex assembly (GO:0010257)	3.49142917
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.49142917
28	purine deoxyribonucleotide catabolic process (GO:0009155)	3.48846584
29	negative regulation of telomerase activity (GO:0051974)	3.42741181
30	regulation of B cell differentiation (GO:0045577)	3.42232947
31	positive regulation of interleukin-8 secretion (GO:2000484)	3.41875065
32	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39271956
33	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.36307589
34	ubiquinone biosynthetic process (GO:0006744)	3.32415595
35	negative regulation of B cell apoptotic process (GO:0002903)	3.29648640
36	metallo-sulfur cluster assembly (GO:0031163)	3.21573933
37	iron-sulfur cluster assembly (GO:0016226)	3.21573933
38	peptidyl-arginine omega-N-methylation (GO:0035247)	3.15782772
39	pyrimidine nucleoside catabolic process (GO:0046135)	3.11306426
40	ATP synthesis coupled proton transport (GO:0015986)	3.07094822
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.07094822
42	GTP biosynthetic process (GO:0006183)	3.03788641
43	regulation of telomere maintenance (GO:0032204)	3.01814838
44	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.97083685
45	respiratory burst (GO:0045730)	2.96965342
46	2-deoxyribonucleotide metabolic process (GO:0009394)	2.95281882
47	regulation of helicase activity (GO:0051095)	2.95121241
48	positive regulation of TOR signaling (GO:0032008)	2.92919955
49	cellular response to interferon-beta (GO:0035458)	2.91833881
50	ubiquinone metabolic process (GO:0006743)	2.87136465
51	purine-containing compound salvage (GO:0043101)	2.85263391
52	pyrimidine-containing compound catabolic process (GO:0072529)	2.83250315
53	protein neddylation (GO:0045116)	2.80923692
54	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.79507933
55	immunoglobulin mediated immune response (GO:0016064)	2.78254869
56	protein polyglutamylation (GO:0018095)	2.76644042
57	deoxyribose phosphate metabolic process (GO:0019692)	2.76610300
58	GPI anchor biosynthetic process (GO:0006506)	2.76066357
59	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.74712018
60	electron transport chain (GO:0022900)	2.74267347
61	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.74186778
62	GPI anchor metabolic process (GO:0006505)	2.73980533
63	protein insertion into membrane (GO:0051205)	2.73759173
64	regulation of telomerase activity (GO:0051972)	2.72862592
65	respiratory electron transport chain (GO:0022904)	2.71244993
66	positive regulation of gamma-delta T cell activation (GO:0046645)	2.71035673
67	positive regulation of DNA biosynthetic process (GO:2000573)	2.70796790
68	response to interferon-beta (GO:0035456)	2.69910814
69	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.69216194
70	DNA damage response, detection of DNA damage (GO:0042769)	2.69121726
71	mucosal-associated lymphoid tissue development (GO:0048537)	2.65566264
72	Peyers patch development (GO:0048541)	2.65566264
73	quinone biosynthetic process (GO:1901663)	2.62102760
74	thrombin receptor signaling pathway (GO:0070493)	2.60610402
75	positive regulation of cellular response to oxidative stress (GO:1900409)	2.57436164
76	positive regulation of response to oxidative stress (GO:1902884)	2.57436164
77	negative regulation by host of viral transcription (GO:0043922)	2.54515040
78	regulation of B cell apoptotic process (GO:0002902)	2.53762826
79	regulation of regulatory T cell differentiation (GO:0045589)	2.53556883
80	DNA damage induced protein phosphorylation (GO:0006975)	2.52749015
81	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.51803145
82	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.51803145
83	superoxide anion generation (GO:0042554)	2.50741641
84	adenosine metabolic process (GO:0046085)	2.49966831
85	negative regulation of stress fiber assembly (GO:0051497)	2.49688409
86	regulation of activation of Janus kinase activity (GO:0010533)	2.49402292
87	DNA demethylation (GO:0080111)	2.48765631
88	UTP biosynthetic process (GO:0006228)	2.48156608
89	purine nucleotide salvage (GO:0032261)	2.46750018
90	regulation of gamma-delta T cell differentiation (GO:0045586)	2.44960606
91	purine deoxyribonucleotide metabolic process (GO:0009151)	2.44741607
92	deoxyribonucleotide metabolic process (GO:0009262)	2.43968105
93	autophagic vacuole fusion (GO:0000046)	2.43820537
94	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.43761933
95	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.42491830
96	positive thymic T cell selection (GO:0045059)	2.41566363
97	positive regulation of defense response to virus by host (GO:0002230)	2.39942798
98	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.39095575
99	telomere maintenance via telomerase (GO:0007004)	2.39015395
100	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.37256765

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.33728041
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.02988631
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.51948193
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.18599841
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.03844298
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.03700477
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.02723628
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.73407530
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.67298823
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.62950591
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.52698460
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.51018847
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.49031804
14	CIITA_25753668_ChIP-Seq_RAJI_Human	2.42172858
15	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.39388818
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.38408443
17	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.31935068
18	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.30992642
19	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.29061319
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.25762252
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18672206
22	VDR_23849224_ChIP-Seq_CD4+_Human	2.13645424
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.04179723
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.00106907
25	SCL_19346495_ChIP-Seq_HPC-7_Human	1.98942993
26	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.98498706
27	BCL6_27268052_Chip-Seq_Bcells_Human	1.97384678
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.94897194
29	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.92025639
30	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.86918467
31	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.83692609
32	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.82150967
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79907719
34	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.76164663
35	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.74985745
36	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.73781046
37	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.70842162
38	IGF1R_20145208_ChIP-Seq_DFB_Human	1.69474222
39	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.66005181
40	ZNF274_21170338_ChIP-Seq_K562_Hela	1.63602794
41	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.63274147
42	MYB_26560356_Chip-Seq_TH2_Human	1.56952169
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.54457243
44	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.54020138
45	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.50013394
46	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.46780720
47	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.46732376
48	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.46427492
49	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.46093350
50	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.45345295
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.44456360
52	SPI1_23547873_ChIP-Seq_NB4_Human	1.41868881
53	UTX_26944678_Chip-Seq_JUKART_Human	1.41424311
54	E2F1_20622854_ChIP-Seq_HELA_Human	1.38265517
55	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.37682600
56	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.36903633
57	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.35321975
58	BCOR_27268052_Chip-Seq_Bcells_Human	1.34517795
59	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.33226966
60	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.32517142
61	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.31751960
62	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.30977155
63	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.30296381
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.28323900
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.27937435
66	XRN2_22483619_ChIP-Seq_HELA_Human	1.27750302
67	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.27660837
68	MAF_26560356_Chip-Seq_TH2_Human	1.27517674
69	DCP1A_22483619_ChIP-Seq_HELA_Human	1.25210809
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.24036437
71	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.23749251
72	P300_27268052_Chip-Seq_Bcells_Human	1.23548069
73	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.23542136
74	GATA3_27048872_Chip-Seq_THYMUS_Human	1.23227426
75	RUNX_20019798_ChIP-Seq_JUKART_Human	1.21550993
76	PHF8_20622854_ChIP-Seq_HELA_Human	1.20648501
77	E2F7_22180533_ChIP-Seq_HELA_Human	1.17765310
78	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.12160186
79	MAF_26560356_Chip-Seq_TH1_Human	1.09441560
80	ERA_21632823_ChIP-Seq_H3396_Human	1.07103474
81	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.06826306
82	MYB_26560356_Chip-Seq_TH1_Human	1.05894611
83	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04902276
84	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.03489889
85	CTCF_20526341_ChIP-Seq_ESCs_Human	1.02930713
86	STAT1_20625510_ChIP-Seq_HELA_Human	1.02213837
87	VDR_21846776_ChIP-Seq_THP-1_Human	1.02072159
88	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.01072992
89	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.00923950
90	TTF2_22483619_ChIP-Seq_HELA_Human	0.99781523
91	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.99715545
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99539225
93	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.98716480
94	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.97228305
95	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.96050661
96	AR_20517297_ChIP-Seq_VCAP_Human	0.95851945
97	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94411146
98	SPI1_20517297_ChIP-Seq_HL60_Human	0.94388401
99	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.94242534
100	P68_20966046_ChIP-Seq_HELA_Human	0.93045253

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.19716091
2	MP0002822_catalepsy	2.95007595
3	MP0005671_abnormal_response_to	2.82284054
4	MP0001835_abnormal_antigen_presentation	2.74306480
5	MP0003806_abnormal_nucleotide_metabolis	2.65557799
6	MP0005464_abnormal_platelet_physiology	2.58293338
7	MP0002132_abnormal_respiratory_system	2.31746189
8	MP0002638_abnormal_pupillary_reflex	2.26379214
9	MP0009785_altered_susceptibility_to	2.22204039
10	MP0002102_abnormal_ear_morphology	2.15596273
11	MP0002148_abnormal_hypersensitivity_rea	2.11211232
12	MP0003763_abnormal_thymus_physiology	2.07509034
13	MP0009333_abnormal_splenocyte_physiolog	2.06288037
14	MP0003436_decreased_susceptibility_to	2.00905074
15	MP0000465_gastrointestinal_hemorrhage	1.86149669
16	MP0001764_abnormal_homeostasis	1.84966578
17	MP0001800_abnormal_humoral_immune	1.76771477
18	MP0008995_early_reproductive_senescence	1.75232420
19	MP0002398_abnormal_bone_marrow	1.74656050
20	MP0006276_abnormal_autonomic_nervous	1.73109407
21	MP0005000_abnormal_immune_tolerance	1.73047778
22	MP0002723_abnormal_immune_serum	1.72879434
23	MP0002420_abnormal_adaptive_immunity	1.72705758
24	MP0009697_abnormal_copulation	1.72139800
25	MP0005025_abnormal_response_to	1.69690437
26	MP0001819_abnormal_immune_cell	1.66696861
27	MP0002234_abnormal_pharynx_morphology	1.65337385
28	MP0004133_heterotaxia	1.64956840
29	MP0009278_abnormal_bone_marrow	1.64680180
30	MP0000689_abnormal_spleen_morphology	1.63703222
31	MP0009764_decreased_sensitivity_to	1.60851878
32	MP0002722_abnormal_immune_system	1.57540933
33	MP0002452_abnormal_antigen_presenting	1.52575090
34	MP0001790_abnormal_immune_system	1.52461014
35	MP0005387_immune_system_phenotype	1.52461014
36	MP0008789_abnormal_olfactory_epithelium	1.50848668
37	MP0000716_abnormal_immune_system	1.46840614
38	MP0000685_abnormal_immune_system	1.46806749
39	MP0000372_irregular_coat_pigmentation	1.45232319
40	MP0005397_hematopoietic_system_phenotyp	1.45057469
41	MP0001545_abnormal_hematopoietic_system	1.45057469
42	MP0008058_abnormal_DNA_repair	1.42704709
43	MP0005084_abnormal_gallbladder_morpholo	1.42679371
44	MP0001905_abnormal_dopamine_level	1.41324644
45	MP0006035_abnormal_mitochondrial_morpho	1.41313506
46	MP0006036_abnormal_mitochondrial_physio	1.40921319
47	MP0005645_abnormal_hypothalamus_physiol	1.39791158
48	MP0008875_abnormal_xenobiotic_pharmacok	1.38817097
49	MP0000703_abnormal_thymus_morphology	1.35095404
50	MP0003786_premature_aging	1.33682614
51	MP0005394_taste/olfaction_phenotype	1.32698893
52	MP0005499_abnormal_olfactory_system	1.32698893
53	MP0002163_abnormal_gland_morphology	1.32430634
54	MP0002429_abnormal_blood_cell	1.31176459
55	MP0002405_respiratory_system_inflammati	1.30588399
56	MP0003880_abnormal_central_pattern	1.26021853
57	MP0006292_abnormal_olfactory_placode	1.25884575
58	MP0008872_abnormal_physiological_respon	1.23938714
59	MP0002419_abnormal_innate_immunity	1.18153710
60	MP0003724_increased_susceptibility_to	1.13196591
61	MP0005075_abnormal_melanosome_morpholog	1.07323228
62	MP0005410_abnormal_fertilization	1.03969454
63	MP0000343_altered_response_to	1.02851834
64	MP0010155_abnormal_intestine_physiology	1.02725937
65	MP0004145_abnormal_muscle_electrophysio	1.00494437
66	MP0001529_abnormal_vocalization	0.99856525
67	MP0001919_abnormal_reproductive_system	0.98998871
68	MP0005646_abnormal_pituitary_gland	0.96172599
69	MP0003186_abnormal_redox_activity	0.94961716
70	MP0002019_abnormal_tumor_incidence	0.94884739
71	MP0003656_abnormal_erythrocyte_physiolo	0.94206144
72	MP0008007_abnormal_cellular_replicative	0.93207839
73	MP0001845_abnormal_inflammatory_respons	0.91179911
74	MP0009763_increased_sensitivity_to	0.90577313
75	MP0003787_abnormal_imprinting	0.90192209
76	MP0008775_abnormal_heart_ventricle	0.89885005
77	MP0008469_abnormal_protein_level	0.86802017
78	MP0006072_abnormal_retinal_apoptosis	0.86614897
79	MP0005376_homeostasis/metabolism_phenot	0.86575038
80	MP0005266_abnormal_metabolism	0.83228182
81	MP0009765_abnormal_xenobiotic_induced	0.82156728
82	MP0001533_abnormal_skeleton_physiology	0.81508286
83	MP0005636_abnormal_mineral_homeostasis	0.81410860
84	MP0005253_abnormal_eye_physiology	0.80424945
85	MP0001542_abnormal_bone_strength	0.78501597
86	MP0000230_abnormal_systemic_arterial	0.78083484
87	MP0008874_decreased_physiological_sensi	0.76040794
88	MP0004043_abnormal_pH_regulation	0.75870048
89	MP0004142_abnormal_muscle_tone	0.75641080
90	MP0002095_abnormal_skin_pigmentation	0.73677769
91	MP0010094_abnormal_chromosome_stability	0.72008918
92	MP0003195_calcinosis	0.70173236
93	MP0002166_altered_tumor_susceptibility	0.70056967
94	MP0005551_abnormal_eye_electrophysiolog	0.67593157
95	MP0003191_abnormal_cellular_cholesterol	0.67542454
96	MP0002127_abnormal_cardiovascular_syste	0.64930409
97	MP0001986_abnormal_taste_sensitivity	0.64422309
98	MP0000639_abnormal_adrenal_gland	0.64144044
99	MP0002693_abnormal_pancreas_physiology	0.62841035
100	MP0002332_abnormal_exercise_endurance	0.62424331

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Panhypogammaglobulinemia (HP:0003139)	4.83272152
2	Severe combined immunodeficiency (HP:0004430)	4.61244514
3	Abnormality of B cell number (HP:0010975)	4.54654199
4	B lymphocytopenia (HP:0010976)	4.46497890
5	Microvesicular hepatic steatosis (HP:0001414)	3.87640051
6	Mitochondrial inheritance (HP:0001427)	3.79111592
7	Aplastic anemia (HP:0001915)	3.60064760
8	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.59655169
9	Agammaglobulinemia (HP:0004432)	3.55463691
10	Hepatocellular necrosis (HP:0001404)	3.50673855
11	Combined immunodeficiency (HP:0005387)	3.43691071
12	Renal Fanconi syndrome (HP:0001994)	3.40520561
13	Abnormality of the prostate (HP:0008775)	3.37304877
14	Hypoproteinemia (HP:0003075)	3.36711113
15	Increased intramyocellular lipid droplets (HP:0012240)	3.36095382
16	Obstructive lung disease (HP:0006536)	3.27934627
17	Chronic obstructive pulmonary disease (HP:0006510)	3.27934627
18	Increased CSF lactate (HP:0002490)	3.27842737
19	3-Methylglutaconic aciduria (HP:0003535)	3.26760495
20	Prolonged bleeding time (HP:0003010)	3.23200395
21	IgG deficiency (HP:0004315)	3.22083926
22	Abnormal mitochondria in muscle tissue (HP:0008316)	3.13988311
23	Increased hepatocellular lipid droplets (HP:0006565)	3.13189084
24	Thyroiditis (HP:0100646)	3.10912491
25	Acute necrotizing encephalopathy (HP:0006965)	3.02300611
26	Hepatic necrosis (HP:0002605)	3.00820857
27	Abnormal number of erythroid precursors (HP:0012131)	2.89986674
28	Increased muscle lipid content (HP:0009058)	2.82984637
29	Hypoplasia of the thymus (HP:0000778)	2.79430559
30	Meningitis (HP:0001287)	2.74422094
31	T lymphocytopenia (HP:0005403)	2.71568257
32	Lipid accumulation in hepatocytes (HP:0006561)	2.66510988
33	Petechiae (HP:0000967)	2.64722582
34	Dicarboxylic aciduria (HP:0003215)	2.63724389
35	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.63724389
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.63181943
37	Acute encephalopathy (HP:0006846)	2.62870447
38	Cerebral edema (HP:0002181)	2.59939980
39	Encephalitis (HP:0002383)	2.57474800
40	Autoimmune hemolytic anemia (HP:0001890)	2.48821820
41	Recurrent viral infections (HP:0004429)	2.42534872
42	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.40171161
43	Abnormality of T cell number (HP:0011839)	2.39796346
44	Abnormality of eosinophils (HP:0001879)	2.36269320
45	Abnormality of transition element cation homeostasis (HP:0011030)	2.36179792
46	Increased IgM level (HP:0003496)	2.34420825
47	Eosinophilia (HP:0001880)	2.34069483
48	Abnormal protein glycosylation (HP:0012346)	2.31750381
49	Abnormal glycosylation (HP:0012345)	2.31750381
50	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.31750381
51	Abnormal protein N-linked glycosylation (HP:0012347)	2.31750381
52	Abnormality of cells of the erythroid lineage (HP:0012130)	2.29599491
53	Granulocytopenia (HP:0001913)	2.28249863
54	Abolished electroretinogram (ERG) (HP:0000550)	2.27892689
55	Lactic acidosis (HP:0003128)	2.26864618
56	Abnormality of iron homeostasis (HP:0011031)	2.24367136
57	Abnormality of male internal genitalia (HP:0000022)	2.24346682
58	Pancytopenia (HP:0001876)	2.24232587
59	Increased serum ferritin (HP:0003281)	2.22848378
60	Progressive macrocephaly (HP:0004481)	2.21404672
61	Purpura (HP:0000979)	2.19875087
62	Recurrent fungal infections (HP:0002841)	2.17528385
63	Abnormal rod and cone electroretinograms (HP:0008323)	2.15763097
64	Abnormal ciliary motility (HP:0012262)	2.15114244
65	Epistaxis (HP:0000421)	2.14962894
66	Stomatitis (HP:0010280)	2.14443447
67	Ureteral stenosis (HP:0000071)	2.14226033
68	Attenuation of retinal blood vessels (HP:0007843)	2.12712040
69	Increased serum lactate (HP:0002151)	2.10062660
70	Abnormality of T cells (HP:0002843)	2.07854967
71	Elevated erythrocyte sedimentation rate (HP:0003565)	2.07280610
72	Recurrent skin infections (HP:0001581)	2.03287826
73	Pulmonary fibrosis (HP:0002206)	2.02118832
74	Ureteral obstruction (HP:0006000)	1.98315202
75	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.98283018
76	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.98283018
77	Exertional dyspnea (HP:0002875)	1.96391151
78	Exercise intolerance (HP:0003546)	1.96316677
79	Ragged-red muscle fibers (HP:0003200)	1.95464482
80	Seborrheic dermatitis (HP:0001051)	1.94817674
81	Type I transferrin isoform profile (HP:0003642)	1.94585827
82	Chronic hepatic failure (HP:0100626)	1.94044127
83	Hypertensive crisis (HP:0100735)	1.93140208
84	Abnormal pupillary function (HP:0007686)	1.92610854
85	Optic disc pallor (HP:0000543)	1.91667384
86	Respiratory difficulties (HP:0002880)	1.91165539
87	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.89918353
88	Autoimmune thrombocytopenia (HP:0001973)	1.88931439
89	Methylmalonic aciduria (HP:0012120)	1.88045195
90	Absent/shortened dynein arms (HP:0200106)	1.85838531
91	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.85838531
92	Abnormality of renal resorption (HP:0011038)	1.85566237
93	Abnormal respiratory epithelium morphology (HP:0012253)	1.85344950
94	Abnormal respiratory motile cilium morphology (HP:0005938)	1.85344950
95	Recurrent bacterial skin infections (HP:0005406)	1.83674114
96	Abnormal respiratory motile cilium physiology (HP:0012261)	1.83208899
97	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.83124795
98	Abnormality of macrophages (HP:0004311)	1.80821768
99	Skin rash (HP:0000988)	1.78145636
100	Medial flaring of the eyebrow (HP:0010747)	1.76750497

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK2	6.27899687
2	TESK2	4.44710805
3	TLK1	3.74262503
4	MAP4K2	3.73809795
5	BCKDK	3.53548232
6	KDR	3.32933118
7	TXK	3.01590710
8	MAP2K6	2.93681777
9	VRK2	2.71004252
10	MAP3K5	2.53790845
11	TAOK3	1.90328326
12	MAP2K7	1.71047662
13	SIK2	1.70393203
14	TESK1	1.68588270
15	CDK8	1.63603142
16	PIM2	1.59631919
17	MAP3K11	1.58079496
18	ADRBK2	1.54544431
19	RIPK4	1.52905062
20	BTK	1.45468046
21	CDK19	1.28756726
22	TEC	1.26120038
23	MAP3K12	1.25214746
24	SYK	1.24519340
25	ITK	1.22346481
26	GRK6	1.20611351
27	MAP3K4	1.19998152
28	KIT	1.19962264
29	ZAK	1.15398596
30	SCYL2	1.15340413
31	FES	1.13194350
32	DAPK1	1.12912906
33	TBK1	1.08072567
34	VRK1	1.01207116
35	MAP4K1	0.94243032
36	MUSK	0.94006504
37	MAPKAPK3	0.88482964
38	IKBKB	0.88297580
39	CCNB1	0.87527845
40	GRK1	0.84911497
41	STK16	0.84888676
42	LIMK1	0.80685017
43	RPS6KA5	0.80103146
44	WNK3	0.79768993
45	TNK2	0.71287739
46	LCK	0.71213902
47	LYN	0.70644565
48	AURKA	0.69838273
49	MAP2K4	0.69564871
50	BLK	0.69129572
51	PIK3CG	0.67469752
52	NME1	0.65372724
53	MAPKAPK5	0.63761483
54	CSF1R	0.62215764
55	PIM1	0.60541694
56	CSNK1G3	0.58638466
57	IRAK4	0.56219205
58	BMPR1B	0.56059072
59	BMX	0.54397389
60	SIK3	0.53466734
61	ATR	0.53382340
62	FLT3	0.53289921
63	SRPK1	0.51620365
64	DAPK3	0.46330766
65	DYRK2	0.45962457
66	MAPK13	0.45933536
67	MST4	0.45868248
68	DAPK2	0.45626562
69	OXSR1	0.44647188
70	NUAK1	0.43518262
71	JAK3	0.42941590
72	TAOK1	0.41820234
73	WNK4	0.39573169
74	ZAP70	0.38344148
75	TAF1	0.36315118
76	JAK2	0.36198760
77	CDK9	0.35358684
78	MAPK11	0.35006654
79	IKBKE	0.34599085
80	RPS6KA4	0.33549289
81	PASK	0.33293109
82	PRKCQ	0.32658172
83	MAPK3	0.32483906
84	CSNK2A2	0.31927045
85	CSNK1A1	0.29317232
86	FYN	0.28475628
87	CSK	0.28431297
88	PIK3CA	0.27998898
89	INSRR	0.27198385
90	DYRK1B	0.27168657
91	CSNK1G1	0.26445743
92	CSNK2A1	0.26173300
93	CLK1	0.25608534
94	MAP3K8	0.24600395
95	MAPK15	0.23986426
96	MAPK4	0.23288050
97	PTK2B	0.22000536
98	MATK	0.21683350
99	GRK5	0.20893978
100	PINK1	0.20321020

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.34330357
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.30378277
3	Proteasome_Homo sapiens_hsa03050	3.17230755
4	Parkinsons disease_Homo sapiens_hsa05012	3.02311521
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.50472623
6	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.46223694
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.03056202
8	DNA replication_Homo sapiens_hsa03030	2.01707118
9	Graft-versus-host disease_Homo sapiens_hsa05332	1.97145407
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.95560546
11	Base excision repair_Homo sapiens_hsa03410	1.93549785
12	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.87984474
13	Allograft rejection_Homo sapiens_hsa05330	1.84522668
14	Homologous recombination_Homo sapiens_hsa03440	1.83888479
15	Asthma_Homo sapiens_hsa05310	1.77377104
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.73605644
17	Ribosome_Homo sapiens_hsa03010	1.69265610
18	Huntingtons disease_Homo sapiens_hsa05016	1.68118600
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.67420474
20	RNA polymerase_Homo sapiens_hsa03020	1.67012194
21	Fatty acid elongation_Homo sapiens_hsa00062	1.64848824
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.63750416
23	Phototransduction_Homo sapiens_hsa04744	1.62139848
24	Rheumatoid arthritis_Homo sapiens_hsa05323	1.56960247
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.56689577
26	Mismatch repair_Homo sapiens_hsa03430	1.56540189
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.53353361
28	Alzheimers disease_Homo sapiens_hsa05010	1.52764215
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.43728308
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.42080919
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.40365597
32	Butanoate metabolism_Homo sapiens_hsa00650	1.40149457
33	Sulfur relay system_Homo sapiens_hsa04122	1.39548516
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.26381194
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.24000835
36	Purine metabolism_Homo sapiens_hsa00230	1.18083597
37	Caffeine metabolism_Homo sapiens_hsa00232	1.16345097
38	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.15831896
39	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.13789898
40	Peroxisome_Homo sapiens_hsa04146	1.13623375
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.07308596
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05279248
43	Regulation of autophagy_Homo sapiens_hsa04140	1.04959682
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04356234
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03935049
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.03492015
47	Shigellosis_Homo sapiens_hsa05131	1.01351022
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.00809960
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96259723
50	Olfactory transduction_Homo sapiens_hsa04740	0.94230284
51	Spliceosome_Homo sapiens_hsa03040	0.84849035
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.79164406
53	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.79047972
54	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.77473979
55	RNA degradation_Homo sapiens_hsa03018	0.74317192
56	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.72873893
57	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.72210330
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71864234
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.71584821
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.68446606
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67740031
62	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.64881914
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.63095944
64	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.62924919
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62728097
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60467017
67	Leishmaniasis_Homo sapiens_hsa05140	0.60163141
68	Basal transcription factors_Homo sapiens_hsa03022	0.59437294
69	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.58843096
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58474516
71	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.57954220
72	Metabolic pathways_Homo sapiens_hsa01100	0.57519219
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.56143316
74	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.54162808
75	Osteoclast differentiation_Homo sapiens_hsa04380	0.53198985
76	Herpes simplex infection_Homo sapiens_hsa05168	0.52119336
77	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.51943956
78	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.51638253
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.51134343
80	Viral myocarditis_Homo sapiens_hsa05416	0.50663002
81	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.49844646
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48814606
83	Pentose phosphate pathway_Homo sapiens_hsa00030	0.46912797
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.46226402
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45873292
86	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.45820455
87	RNA transport_Homo sapiens_hsa03013	0.44211068
88	Phagosome_Homo sapiens_hsa04145	0.44174801
89	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.43858057
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42721554
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42306189
92	Salmonella infection_Homo sapiens_hsa05132	0.41418136
93	Phenylalanine metabolism_Homo sapiens_hsa00360	0.40824689
94	Platelet activation_Homo sapiens_hsa04611	0.39636932
95	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.36438782
96	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.35565109
97	Propanoate metabolism_Homo sapiens_hsa00640	0.35340103
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.35172200
99	Protein export_Homo sapiens_hsa03060	0.31459233
100	Pertussis_Homo sapiens_hsa05133	0.27889543

WASH4P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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