WASH4P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* Arp2/3 complex-mediated actin nucleation (GO:0034314)7.77218069
2* actin nucleation (GO:0045010)6.38939009
3negative regulation of telomere maintenance (GO:0032205)5.90653037
4positive regulation of B cell differentiation (GO:0045579)5.72704375
5sequestering of actin monomers (GO:0042989)5.32589982
6cytidine metabolic process (GO:0046087)5.07022851
7cytidine catabolic process (GO:0006216)5.07022851
8cytidine deamination (GO:0009972)5.07022851
9DNA deamination (GO:0045006)4.94955036
10pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.76041412
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.75069307
12pyrimidine ribonucleoside catabolic process (GO:0046133)4.38726605
13base-excision repair, AP site formation (GO:0006285)4.30608625
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.07166115
15pyrimidine nucleotide catabolic process (GO:0006244)4.03599077
16deoxyribonucleotide catabolic process (GO:0009264)3.85599718
17regulation of telomere maintenance via telomerase (GO:0032210)3.84945823
18negative regulation of T cell apoptotic process (GO:0070233)3.76890303
19deoxyribose phosphate catabolic process (GO:0046386)3.66299751
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64465853
21platelet dense granule organization (GO:0060155)3.58944608
22protein complex biogenesis (GO:0070271)3.57646471
23pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.57485298
24negative regulation of thymocyte apoptotic process (GO:0070244)3.49378642
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.49142917
26NADH dehydrogenase complex assembly (GO:0010257)3.49142917
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49142917
28purine deoxyribonucleotide catabolic process (GO:0009155)3.48846584
29negative regulation of telomerase activity (GO:0051974)3.42741181
30regulation of B cell differentiation (GO:0045577)3.42232947
31positive regulation of interleukin-8 secretion (GO:2000484)3.41875065
32mitochondrial respiratory chain complex assembly (GO:0033108)3.39271956
33negative regulation of lymphocyte apoptotic process (GO:0070229)3.36307589
34ubiquinone biosynthetic process (GO:0006744)3.32415595
35negative regulation of B cell apoptotic process (GO:0002903)3.29648640
36metallo-sulfur cluster assembly (GO:0031163)3.21573933
37iron-sulfur cluster assembly (GO:0016226)3.21573933
38peptidyl-arginine omega-N-methylation (GO:0035247)3.15782772
39pyrimidine nucleoside catabolic process (GO:0046135)3.11306426
40ATP synthesis coupled proton transport (GO:0015986)3.07094822
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07094822
42GTP biosynthetic process (GO:0006183)3.03788641
43regulation of telomere maintenance (GO:0032204)3.01814838
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97083685
45respiratory burst (GO:0045730)2.96965342
462-deoxyribonucleotide metabolic process (GO:0009394)2.95281882
47regulation of helicase activity (GO:0051095)2.95121241
48positive regulation of TOR signaling (GO:0032008)2.92919955
49cellular response to interferon-beta (GO:0035458)2.91833881
50ubiquinone metabolic process (GO:0006743)2.87136465
51purine-containing compound salvage (GO:0043101)2.85263391
52pyrimidine-containing compound catabolic process (GO:0072529)2.83250315
53protein neddylation (GO:0045116)2.80923692
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79507933
55immunoglobulin mediated immune response (GO:0016064)2.78254869
56protein polyglutamylation (GO:0018095)2.76644042
57deoxyribose phosphate metabolic process (GO:0019692)2.76610300
58GPI anchor biosynthetic process (GO:0006506)2.76066357
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.74712018
60electron transport chain (GO:0022900)2.74267347
61negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.74186778
62GPI anchor metabolic process (GO:0006505)2.73980533
63protein insertion into membrane (GO:0051205)2.73759173
64regulation of telomerase activity (GO:0051972)2.72862592
65respiratory electron transport chain (GO:0022904)2.71244993
66positive regulation of gamma-delta T cell activation (GO:0046645)2.71035673
67positive regulation of DNA biosynthetic process (GO:2000573)2.70796790
68response to interferon-beta (GO:0035456)2.69910814
69deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69216194
70DNA damage response, detection of DNA damage (GO:0042769)2.69121726
71mucosal-associated lymphoid tissue development (GO:0048537)2.65566264
72Peyers patch development (GO:0048541)2.65566264
73quinone biosynthetic process (GO:1901663)2.62102760
74thrombin receptor signaling pathway (GO:0070493)2.60610402
75positive regulation of cellular response to oxidative stress (GO:1900409)2.57436164
76positive regulation of response to oxidative stress (GO:1902884)2.57436164
77negative regulation by host of viral transcription (GO:0043922)2.54515040
78regulation of B cell apoptotic process (GO:0002902)2.53762826
79regulation of regulatory T cell differentiation (GO:0045589)2.53556883
80DNA damage induced protein phosphorylation (GO:0006975)2.52749015
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51803145
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51803145
83superoxide anion generation (GO:0042554)2.50741641
84adenosine metabolic process (GO:0046085)2.49966831
85negative regulation of stress fiber assembly (GO:0051497)2.49688409
86regulation of activation of Janus kinase activity (GO:0010533)2.49402292
87DNA demethylation (GO:0080111)2.48765631
88UTP biosynthetic process (GO:0006228)2.48156608
89purine nucleotide salvage (GO:0032261)2.46750018
90regulation of gamma-delta T cell differentiation (GO:0045586)2.44960606
91purine deoxyribonucleotide metabolic process (GO:0009151)2.44741607
92deoxyribonucleotide metabolic process (GO:0009262)2.43968105
93autophagic vacuole fusion (GO:0000046)2.43820537
94positive regulation of natural killer cell mediated immunity (GO:0002717)2.43761933
95negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42491830
96positive thymic T cell selection (GO:0045059)2.41566363
97positive regulation of defense response to virus by host (GO:0002230)2.39942798
98positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.39095575
99telomere maintenance via telomerase (GO:0007004)2.39015395
100negative regulation of calcium ion transport into cytosol (GO:0010523)2.37256765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.33728041
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.02988631
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.51948193
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.18599841
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03844298
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.03700477
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02723628
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73407530
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.67298823
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62950591
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.52698460
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51018847
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49031804
14CIITA_25753668_ChIP-Seq_RAJI_Human2.42172858
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.39388818
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.38408443
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31935068
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.30992642
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.29061319
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25762252
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18672206
22VDR_23849224_ChIP-Seq_CD4+_Human2.13645424
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.04179723
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.00106907
25SCL_19346495_ChIP-Seq_HPC-7_Human1.98942993
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98498706
27BCL6_27268052_Chip-Seq_Bcells_Human1.97384678
28FOXP3_21729870_ChIP-Seq_TREG_Human1.94897194
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92025639
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86918467
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83692609
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82150967
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79907719
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76164663
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74985745
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73781046
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.70842162
38IGF1R_20145208_ChIP-Seq_DFB_Human1.69474222
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66005181
40ZNF274_21170338_ChIP-Seq_K562_Hela1.63602794
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.63274147
42MYB_26560356_Chip-Seq_TH2_Human1.56952169
43MYC_18940864_ChIP-ChIP_HL60_Human1.54457243
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54020138
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50013394
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46780720
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46732376
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46427492
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46093350
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45345295
51GABP_19822575_ChIP-Seq_HepG2_Human1.44456360
52SPI1_23547873_ChIP-Seq_NB4_Human1.41868881
53UTX_26944678_Chip-Seq_JUKART_Human1.41424311
54E2F1_20622854_ChIP-Seq_HELA_Human1.38265517
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37682600
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36903633
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35321975
58BCOR_27268052_Chip-Seq_Bcells_Human1.34517795
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33226966
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32517142
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.31751960
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30977155
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30296381
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28323900
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27937435
66XRN2_22483619_ChIP-Seq_HELA_Human1.27750302
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27660837
68MAF_26560356_Chip-Seq_TH2_Human1.27517674
69DCP1A_22483619_ChIP-Seq_HELA_Human1.25210809
70TP53_22573176_ChIP-Seq_HFKS_Human1.24036437
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23749251
72P300_27268052_Chip-Seq_Bcells_Human1.23548069
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23542136
74GATA3_27048872_Chip-Seq_THYMUS_Human1.23227426
75RUNX_20019798_ChIP-Seq_JUKART_Human1.21550993
76PHF8_20622854_ChIP-Seq_HELA_Human1.20648501
77E2F7_22180533_ChIP-Seq_HELA_Human1.17765310
78CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12160186
79MAF_26560356_Chip-Seq_TH1_Human1.09441560
80ERA_21632823_ChIP-Seq_H3396_Human1.07103474
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06826306
82MYB_26560356_Chip-Seq_TH1_Human1.05894611
83KDM5A_27292631_Chip-Seq_BREAST_Human1.04902276
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03489889
85CTCF_20526341_ChIP-Seq_ESCs_Human1.02930713
86STAT1_20625510_ChIP-Seq_HELA_Human1.02213837
87VDR_21846776_ChIP-Seq_THP-1_Human1.02072159
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01072992
89MYC_18555785_ChIP-Seq_MESCs_Mouse1.00923950
90TTF2_22483619_ChIP-Seq_HELA_Human0.99781523
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99715545
92NANOG_20526341_ChIP-Seq_ESCs_Human0.99539225
93CTCF_26484167_Chip-Seq_Bcells_Mouse0.98716480
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97228305
95FOXP1_21924763_ChIP-Seq_HESCs_Human0.96050661
96AR_20517297_ChIP-Seq_VCAP_Human0.95851945
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94411146
98SPI1_20517297_ChIP-Seq_HL60_Human0.94388401
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94242534
100P68_20966046_ChIP-Seq_HELA_Human0.93045253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.19716091
2MP0002822_catalepsy2.95007595
3MP0005671_abnormal_response_to2.82284054
4MP0001835_abnormal_antigen_presentation2.74306480
5MP0003806_abnormal_nucleotide_metabolis2.65557799
6MP0005464_abnormal_platelet_physiology2.58293338
7MP0002132_abnormal_respiratory_system2.31746189
8MP0002638_abnormal_pupillary_reflex2.26379214
9MP0009785_altered_susceptibility_to2.22204039
10MP0002102_abnormal_ear_morphology2.15596273
11MP0002148_abnormal_hypersensitivity_rea2.11211232
12MP0003763_abnormal_thymus_physiology2.07509034
13MP0009333_abnormal_splenocyte_physiolog2.06288037
14MP0003436_decreased_susceptibility_to2.00905074
15MP0000465_gastrointestinal_hemorrhage1.86149669
16MP0001764_abnormal_homeostasis1.84966578
17MP0001800_abnormal_humoral_immune1.76771477
18MP0008995_early_reproductive_senescence1.75232420
19MP0002398_abnormal_bone_marrow1.74656050
20MP0006276_abnormal_autonomic_nervous1.73109407
21MP0005000_abnormal_immune_tolerance1.73047778
22MP0002723_abnormal_immune_serum1.72879434
23MP0002420_abnormal_adaptive_immunity1.72705758
24MP0009697_abnormal_copulation1.72139800
25MP0005025_abnormal_response_to1.69690437
26MP0001819_abnormal_immune_cell1.66696861
27MP0002234_abnormal_pharynx_morphology1.65337385
28MP0004133_heterotaxia1.64956840
29MP0009278_abnormal_bone_marrow1.64680180
30MP0000689_abnormal_spleen_morphology1.63703222
31MP0009764_decreased_sensitivity_to1.60851878
32MP0002722_abnormal_immune_system1.57540933
33MP0002452_abnormal_antigen_presenting1.52575090
34MP0001790_abnormal_immune_system1.52461014
35MP0005387_immune_system_phenotype1.52461014
36MP0008789_abnormal_olfactory_epithelium1.50848668
37MP0000716_abnormal_immune_system1.46840614
38MP0000685_abnormal_immune_system1.46806749
39MP0000372_irregular_coat_pigmentation1.45232319
40MP0005397_hematopoietic_system_phenotyp1.45057469
41MP0001545_abnormal_hematopoietic_system1.45057469
42MP0008058_abnormal_DNA_repair1.42704709
43MP0005084_abnormal_gallbladder_morpholo1.42679371
44MP0001905_abnormal_dopamine_level1.41324644
45MP0006035_abnormal_mitochondrial_morpho1.41313506
46MP0006036_abnormal_mitochondrial_physio1.40921319
47MP0005645_abnormal_hypothalamus_physiol1.39791158
48MP0008875_abnormal_xenobiotic_pharmacok1.38817097
49MP0000703_abnormal_thymus_morphology1.35095404
50MP0003786_premature_aging1.33682614
51MP0005394_taste/olfaction_phenotype1.32698893
52MP0005499_abnormal_olfactory_system1.32698893
53MP0002163_abnormal_gland_morphology1.32430634
54MP0002429_abnormal_blood_cell1.31176459
55MP0002405_respiratory_system_inflammati1.30588399
56MP0003880_abnormal_central_pattern1.26021853
57MP0006292_abnormal_olfactory_placode1.25884575
58MP0008872_abnormal_physiological_respon1.23938714
59MP0002419_abnormal_innate_immunity1.18153710
60MP0003724_increased_susceptibility_to1.13196591
61MP0005075_abnormal_melanosome_morpholog1.07323228
62MP0005410_abnormal_fertilization1.03969454
63MP0000343_altered_response_to1.02851834
64MP0010155_abnormal_intestine_physiology1.02725937
65MP0004145_abnormal_muscle_electrophysio1.00494437
66MP0001529_abnormal_vocalization0.99856525
67MP0001919_abnormal_reproductive_system0.98998871
68MP0005646_abnormal_pituitary_gland0.96172599
69MP0003186_abnormal_redox_activity0.94961716
70MP0002019_abnormal_tumor_incidence0.94884739
71MP0003656_abnormal_erythrocyte_physiolo0.94206144
72MP0008007_abnormal_cellular_replicative0.93207839
73MP0001845_abnormal_inflammatory_respons0.91179911
74MP0009763_increased_sensitivity_to0.90577313
75MP0003787_abnormal_imprinting0.90192209
76MP0008775_abnormal_heart_ventricle0.89885005
77MP0008469_abnormal_protein_level0.86802017
78MP0006072_abnormal_retinal_apoptosis0.86614897
79MP0005376_homeostasis/metabolism_phenot0.86575038
80MP0005266_abnormal_metabolism0.83228182
81MP0009765_abnormal_xenobiotic_induced0.82156728
82MP0001533_abnormal_skeleton_physiology0.81508286
83MP0005636_abnormal_mineral_homeostasis0.81410860
84MP0005253_abnormal_eye_physiology0.80424945
85MP0001542_abnormal_bone_strength0.78501597
86MP0000230_abnormal_systemic_arterial0.78083484
87MP0008874_decreased_physiological_sensi0.76040794
88MP0004043_abnormal_pH_regulation0.75870048
89MP0004142_abnormal_muscle_tone0.75641080
90MP0002095_abnormal_skin_pigmentation0.73677769
91MP0010094_abnormal_chromosome_stability0.72008918
92MP0003195_calcinosis0.70173236
93MP0002166_altered_tumor_susceptibility0.70056967
94MP0005551_abnormal_eye_electrophysiolog0.67593157
95MP0003191_abnormal_cellular_cholesterol0.67542454
96MP0002127_abnormal_cardiovascular_syste0.64930409
97MP0001986_abnormal_taste_sensitivity0.64422309
98MP0000639_abnormal_adrenal_gland0.64144044
99MP0002693_abnormal_pancreas_physiology0.62841035
100MP0002332_abnormal_exercise_endurance0.62424331

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)4.83272152
2Severe combined immunodeficiency (HP:0004430)4.61244514
3Abnormality of B cell number (HP:0010975)4.54654199
4B lymphocytopenia (HP:0010976)4.46497890
5Microvesicular hepatic steatosis (HP:0001414)3.87640051
6Mitochondrial inheritance (HP:0001427)3.79111592
7Aplastic anemia (HP:0001915)3.60064760
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.59655169
9Agammaglobulinemia (HP:0004432)3.55463691
10Hepatocellular necrosis (HP:0001404)3.50673855
11Combined immunodeficiency (HP:0005387)3.43691071
12Renal Fanconi syndrome (HP:0001994)3.40520561
13Abnormality of the prostate (HP:0008775)3.37304877
14Hypoproteinemia (HP:0003075)3.36711113
15Increased intramyocellular lipid droplets (HP:0012240)3.36095382
16Obstructive lung disease (HP:0006536)3.27934627
17Chronic obstructive pulmonary disease (HP:0006510)3.27934627
18Increased CSF lactate (HP:0002490)3.27842737
193-Methylglutaconic aciduria (HP:0003535)3.26760495
20Prolonged bleeding time (HP:0003010)3.23200395
21IgG deficiency (HP:0004315)3.22083926
22Abnormal mitochondria in muscle tissue (HP:0008316)3.13988311
23Increased hepatocellular lipid droplets (HP:0006565)3.13189084
24Thyroiditis (HP:0100646)3.10912491
25Acute necrotizing encephalopathy (HP:0006965)3.02300611
26Hepatic necrosis (HP:0002605)3.00820857
27Abnormal number of erythroid precursors (HP:0012131)2.89986674
28Increased muscle lipid content (HP:0009058)2.82984637
29Hypoplasia of the thymus (HP:0000778)2.79430559
30Meningitis (HP:0001287)2.74422094
31T lymphocytopenia (HP:0005403)2.71568257
32Lipid accumulation in hepatocytes (HP:0006561)2.66510988
33Petechiae (HP:0000967)2.64722582
34Dicarboxylic aciduria (HP:0003215)2.63724389
35Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63724389
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63181943
37Acute encephalopathy (HP:0006846)2.62870447
38Cerebral edema (HP:0002181)2.59939980
39Encephalitis (HP:0002383)2.57474800
40Autoimmune hemolytic anemia (HP:0001890)2.48821820
41Recurrent viral infections (HP:0004429)2.42534872
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.40171161
43Abnormality of T cell number (HP:0011839)2.39796346
44Abnormality of eosinophils (HP:0001879)2.36269320
45Abnormality of transition element cation homeostasis (HP:0011030)2.36179792
46Increased IgM level (HP:0003496)2.34420825
47Eosinophilia (HP:0001880)2.34069483
48Abnormal protein glycosylation (HP:0012346)2.31750381
49Abnormal glycosylation (HP:0012345)2.31750381
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31750381
51Abnormal protein N-linked glycosylation (HP:0012347)2.31750381
52Abnormality of cells of the erythroid lineage (HP:0012130)2.29599491
53Granulocytopenia (HP:0001913)2.28249863
54Abolished electroretinogram (ERG) (HP:0000550)2.27892689
55Lactic acidosis (HP:0003128)2.26864618
56Abnormality of iron homeostasis (HP:0011031)2.24367136
57Abnormality of male internal genitalia (HP:0000022)2.24346682
58Pancytopenia (HP:0001876)2.24232587
59Increased serum ferritin (HP:0003281)2.22848378
60Progressive macrocephaly (HP:0004481)2.21404672
61Purpura (HP:0000979)2.19875087
62Recurrent fungal infections (HP:0002841)2.17528385
63Abnormal rod and cone electroretinograms (HP:0008323)2.15763097
64Abnormal ciliary motility (HP:0012262)2.15114244
65Epistaxis (HP:0000421)2.14962894
66Stomatitis (HP:0010280)2.14443447
67Ureteral stenosis (HP:0000071)2.14226033
68Attenuation of retinal blood vessels (HP:0007843)2.12712040
69Increased serum lactate (HP:0002151)2.10062660
70Abnormality of T cells (HP:0002843)2.07854967
71Elevated erythrocyte sedimentation rate (HP:0003565)2.07280610
72Recurrent skin infections (HP:0001581)2.03287826
73Pulmonary fibrosis (HP:0002206)2.02118832
74Ureteral obstruction (HP:0006000)1.98315202
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98283018
76Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98283018
77Exertional dyspnea (HP:0002875)1.96391151
78Exercise intolerance (HP:0003546)1.96316677
79Ragged-red muscle fibers (HP:0003200)1.95464482
80Seborrheic dermatitis (HP:0001051)1.94817674
81Type I transferrin isoform profile (HP:0003642)1.94585827
82Chronic hepatic failure (HP:0100626)1.94044127
83Hypertensive crisis (HP:0100735)1.93140208
84Abnormal pupillary function (HP:0007686)1.92610854
85Optic disc pallor (HP:0000543)1.91667384
86Respiratory difficulties (HP:0002880)1.91165539
87Aplasia/Hypoplasia of the thymus (HP:0010515)1.89918353
88Autoimmune thrombocytopenia (HP:0001973)1.88931439
89Methylmalonic aciduria (HP:0012120)1.88045195
90Absent/shortened dynein arms (HP:0200106)1.85838531
91Dynein arm defect of respiratory motile cilia (HP:0012255)1.85838531
92Abnormality of renal resorption (HP:0011038)1.85566237
93Abnormal respiratory epithelium morphology (HP:0012253)1.85344950
94Abnormal respiratory motile cilium morphology (HP:0005938)1.85344950
95Recurrent bacterial skin infections (HP:0005406)1.83674114
96Abnormal respiratory motile cilium physiology (HP:0012261)1.83208899
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83124795
98Abnormality of macrophages (HP:0004311)1.80821768
99Skin rash (HP:0000988)1.78145636
100Medial flaring of the eyebrow (HP:0010747)1.76750497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK26.27899687
2TESK24.44710805
3TLK13.74262503
4MAP4K23.73809795
5BCKDK3.53548232
6KDR3.32933118
7TXK3.01590710
8MAP2K62.93681777
9VRK22.71004252
10MAP3K52.53790845
11TAOK31.90328326
12MAP2K71.71047662
13SIK21.70393203
14TESK11.68588270
15CDK81.63603142
16PIM21.59631919
17MAP3K111.58079496
18ADRBK21.54544431
19RIPK41.52905062
20BTK1.45468046
21CDK191.28756726
22TEC1.26120038
23MAP3K121.25214746
24SYK1.24519340
25ITK1.22346481
26GRK61.20611351
27MAP3K41.19998152
28KIT1.19962264
29ZAK1.15398596
30SCYL21.15340413
31FES1.13194350
32DAPK11.12912906
33TBK11.08072567
34VRK11.01207116
35MAP4K10.94243032
36MUSK0.94006504
37MAPKAPK30.88482964
38IKBKB0.88297580
39CCNB10.87527845
40GRK10.84911497
41STK160.84888676
42LIMK10.80685017
43RPS6KA50.80103146
44WNK30.79768993
45TNK20.71287739
46LCK0.71213902
47LYN0.70644565
48AURKA0.69838273
49MAP2K40.69564871
50BLK0.69129572
51PIK3CG0.67469752
52NME10.65372724
53MAPKAPK50.63761483
54CSF1R0.62215764
55PIM10.60541694
56CSNK1G30.58638466
57IRAK40.56219205
58BMPR1B0.56059072
59BMX0.54397389
60SIK30.53466734
61ATR0.53382340
62FLT30.53289921
63SRPK10.51620365
64DAPK30.46330766
65DYRK20.45962457
66MAPK130.45933536
67MST40.45868248
68DAPK20.45626562
69OXSR10.44647188
70NUAK10.43518262
71JAK30.42941590
72TAOK10.41820234
73WNK40.39573169
74ZAP700.38344148
75TAF10.36315118
76JAK20.36198760
77CDK90.35358684
78MAPK110.35006654
79IKBKE0.34599085
80RPS6KA40.33549289
81PASK0.33293109
82PRKCQ0.32658172
83MAPK30.32483906
84CSNK2A20.31927045
85CSNK1A10.29317232
86FYN0.28475628
87CSK0.28431297
88PIK3CA0.27998898
89INSRR0.27198385
90DYRK1B0.27168657
91CSNK1G10.26445743
92CSNK2A10.26173300
93CLK10.25608534
94MAP3K80.24600395
95MAPK150.23986426
96MAPK40.23288050
97PTK2B0.22000536
98MATK0.21683350
99GRK50.20893978
100PINK10.20321020

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.34330357
2Oxidative phosphorylation_Homo sapiens_hsa001903.30378277
3Proteasome_Homo sapiens_hsa030503.17230755
4Parkinsons disease_Homo sapiens_hsa050123.02311521
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.50472623
6Hematopoietic cell lineage_Homo sapiens_hsa046402.46223694
7Autoimmune thyroid disease_Homo sapiens_hsa053202.03056202
8DNA replication_Homo sapiens_hsa030302.01707118
9Graft-versus-host disease_Homo sapiens_hsa053321.97145407
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.95560546
11Base excision repair_Homo sapiens_hsa034101.93549785
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87984474
13Allograft rejection_Homo sapiens_hsa053301.84522668
14Homologous recombination_Homo sapiens_hsa034401.83888479
15Asthma_Homo sapiens_hsa053101.77377104
16Antigen processing and presentation_Homo sapiens_hsa046121.73605644
17Ribosome_Homo sapiens_hsa030101.69265610
18Huntingtons disease_Homo sapiens_hsa050161.68118600
19Pyrimidine metabolism_Homo sapiens_hsa002401.67420474
20RNA polymerase_Homo sapiens_hsa030201.67012194
21Fatty acid elongation_Homo sapiens_hsa000621.64848824
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63750416
23Phototransduction_Homo sapiens_hsa047441.62139848
24Rheumatoid arthritis_Homo sapiens_hsa053231.56960247
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56689577
26Mismatch repair_Homo sapiens_hsa034301.56540189
27Type I diabetes mellitus_Homo sapiens_hsa049401.53353361
28Alzheimers disease_Homo sapiens_hsa050101.52764215
29Nucleotide excision repair_Homo sapiens_hsa034201.43728308
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42080919
31Fanconi anemia pathway_Homo sapiens_hsa034601.40365597
32Butanoate metabolism_Homo sapiens_hsa006501.40149457
33Sulfur relay system_Homo sapiens_hsa041221.39548516
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26381194
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24000835
36Purine metabolism_Homo sapiens_hsa002301.18083597
37Caffeine metabolism_Homo sapiens_hsa002321.16345097
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15831896
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.13789898
40Peroxisome_Homo sapiens_hsa041461.13623375
41Cardiac muscle contraction_Homo sapiens_hsa042601.07308596
42Collecting duct acid secretion_Homo sapiens_hsa049661.05279248
43Regulation of autophagy_Homo sapiens_hsa041401.04959682
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04356234
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03935049
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.03492015
47Shigellosis_Homo sapiens_hsa051311.01351022
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00809960
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96259723
50Olfactory transduction_Homo sapiens_hsa047400.94230284
51Spliceosome_Homo sapiens_hsa030400.84849035
52Non-homologous end-joining_Homo sapiens_hsa034500.79164406
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.79047972
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77473979
55RNA degradation_Homo sapiens_hsa030180.74317192
56Staphylococcus aureus infection_Homo sapiens_hsa051500.72873893
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72210330
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71864234
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71584821
60Systemic lupus erythematosus_Homo sapiens_hsa053220.68446606
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67740031
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64881914
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63095944
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62924919
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62728097
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60467017
67Leishmaniasis_Homo sapiens_hsa051400.60163141
68Basal transcription factors_Homo sapiens_hsa030220.59437294
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58843096
70Arachidonic acid metabolism_Homo sapiens_hsa005900.58474516
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57954220
72Metabolic pathways_Homo sapiens_hsa011000.57519219
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56143316
74Biosynthesis of amino acids_Homo sapiens_hsa012300.54162808
75Osteoclast differentiation_Homo sapiens_hsa043800.53198985
76Herpes simplex infection_Homo sapiens_hsa051680.52119336
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51943956
78T cell receptor signaling pathway_Homo sapiens_hsa046600.51638253
79Nitrogen metabolism_Homo sapiens_hsa009100.51134343
80Viral myocarditis_Homo sapiens_hsa054160.50663002
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.49844646
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48814606
83Pentose phosphate pathway_Homo sapiens_hsa000300.46912797
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.46226402
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45873292
86Epstein-Barr virus infection_Homo sapiens_hsa051690.45820455
87RNA transport_Homo sapiens_hsa030130.44211068
88Phagosome_Homo sapiens_hsa041450.44174801
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43858057
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42721554
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.42306189
92Salmonella infection_Homo sapiens_hsa051320.41418136
93Phenylalanine metabolism_Homo sapiens_hsa003600.40824689
94Platelet activation_Homo sapiens_hsa046110.39636932
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36438782
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35565109
97Propanoate metabolism_Homo sapiens_hsa006400.35340103
98Selenocompound metabolism_Homo sapiens_hsa004500.35172200
99Protein export_Homo sapiens_hsa030600.31459233
100Pertussis_Homo sapiens_hsa051330.27889543

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