WASH6P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.74839077
2positive regulation of gamma-delta T cell activation (GO:0046645)5.24471699
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.01618205
4negative regulation of cell killing (GO:0031342)5.01618205
5mannose metabolic process (GO:0006013)4.68765945
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.62759599
7antigen processing and presentation of endogenous antigen (GO:0019883)4.46382502
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.44496757
9* Arp2/3 complex-mediated actin nucleation (GO:0034314)4.41174081
10response to muramyl dipeptide (GO:0032495)4.26925390
11positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.25179058
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24262109
13positive thymic T cell selection (GO:0045059)4.19365497
14detection of bacterium (GO:0016045)3.96248090
15regulation of gamma-delta T cell activation (GO:0046643)3.93018361
16thymic T cell selection (GO:0045061)3.91528592
17response to peptidoglycan (GO:0032494)3.80072959
18detection of other organism (GO:0098543)3.73560667
19regulation of gamma-delta T cell differentiation (GO:0045586)3.65743825
20negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.60985911
21positive regulation by symbiont of host defense response (GO:0052509)3.59501887
22modulation by symbiont of host defense response (GO:0052031)3.59501887
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59501887
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59501887
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.59501887
26modulation by symbiont of host immune response (GO:0052553)3.59501887
27NIK/NF-kappaB signaling (GO:0038061)3.51782429
28neutrophil activation involved in immune response (GO:0002283)3.50733914
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50667192
30positive regulation of B cell differentiation (GO:0045579)3.50463104
31negative thymic T cell selection (GO:0045060)3.47706225
32* actin nucleation (GO:0045010)3.43143476
33B cell receptor signaling pathway (GO:0050853)3.42618774
34T cell selection (GO:0045058)3.37396306
35regulation of ARF GTPase activity (GO:0032312)3.36162875
36regulation of B cell receptor signaling pathway (GO:0050855)3.27951126
37negative T cell selection (GO:0043383)3.26889289
38macrophage activation involved in immune response (GO:0002281)3.25284779
39leukocyte aggregation (GO:0070486)3.15810271
40CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.15408910
41germinal center formation (GO:0002467)3.13266736
42positive T cell selection (GO:0043368)3.12937474
43negative regulation of granulocyte differentiation (GO:0030853)3.12601584
44modulation by virus of host process (GO:0019054)3.11310191
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.11229904
46regulation of mast cell degranulation (GO:0043304)3.10770439
47negative regulation of innate immune response (GO:0045824)3.09639377
48negative regulation of interleukin-12 production (GO:0032695)3.08180799
49immunoglobulin mediated immune response (GO:0016064)3.03895881
50negative regulation of T cell mediated immunity (GO:0002710)2.96603347
51negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94867103
52negative regulation of leukocyte mediated immunity (GO:0002704)2.93452038
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.92159841
54regulation of myeloid leukocyte mediated immunity (GO:0002886)2.91993300
55positive regulation of protein kinase C signaling (GO:0090037)2.91890553
56regulation of interferon-beta biosynthetic process (GO:0045357)2.90024544
57detection of external biotic stimulus (GO:0098581)2.83770068
58regulation of hydrogen peroxide metabolic process (GO:0010310)2.83060609
59regulation of B cell differentiation (GO:0045577)2.82569708
60regulation of leukocyte degranulation (GO:0043300)2.81945773
61response to protozoan (GO:0001562)2.81315587
62mucosal-associated lymphoid tissue development (GO:0048537)2.81187208
63Peyers patch development (GO:0048541)2.81187208
64regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80726448
65response to interleukin-15 (GO:0070672)2.80591550
66defense response to protozoan (GO:0042832)2.75963495
67response to type I interferon (GO:0034340)2.75016628
68adenosine receptor signaling pathway (GO:0001973)2.74819997
69modulation by symbiont of host cellular process (GO:0044068)2.71487287
70regulation of granulocyte differentiation (GO:0030852)2.71283790
71positive regulation of antigen processing and presentation (GO:0002579)2.71012142
72regulation of mast cell activation involved in immune response (GO:0033006)2.68426424
73cellular response to virus (GO:0098586)2.67815816
74regulation of antigen processing and presentation (GO:0002577)2.66762283
75cellular response to type I interferon (GO:0071357)2.66197074
76type I interferon signaling pathway (GO:0060337)2.66197074
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.65874079
78regulation of natural killer cell mediated immunity (GO:0002715)2.65874079
79tolerance induction (GO:0002507)2.62953456
80histone H4 deacetylation (GO:0070933)2.62691296
81negative regulation of tumor necrosis factor production (GO:0032720)2.62599229
82myeloid cell activation involved in immune response (GO:0002275)2.61484940
83respiratory burst (GO:0045730)2.61321042
84regulation of interleukin-2 biosynthetic process (GO:0045076)2.61187230
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60595609
86regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60232660
87positive regulation of histone deacetylation (GO:0031065)2.60019050
88neutrophil activation (GO:0042119)2.59704425
89granulocyte activation (GO:0036230)2.58920454
90T cell migration (GO:0072678)2.58742046
91phosphatidylglycerol biosynthetic process (GO:0006655)2.58401338
92detection of biotic stimulus (GO:0009595)2.57932586
93negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.57443221
94regulation of monocyte differentiation (GO:0045655)2.55662663
95regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.54188739
96activated T cell proliferation (GO:0050798)2.51800987
97regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.51747667
98GDP-mannose metabolic process (GO:0019673)2.49223045
99negative regulation of interleukin-6 production (GO:0032715)2.48280508
100regulation of tumor necrosis factor production (GO:0032680)2.47853555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.92598455
2LXR_22292898_ChIP-Seq_THP-1_Human2.99572064
3MYC_22102868_ChIP-Seq_BL_Human2.93127650
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.69051161
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63569207
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.59794730
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.49259732
8KDM2B_26808549_Chip-Seq_DND41_Human2.42688849
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.42584958
10VDR_24763502_ChIP-Seq_THP-1_Human2.36608791
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36252160
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30002963
13TCF7_22412390_ChIP-Seq_EML_Mouse2.26404160
14MAF_26560356_Chip-Seq_TH1_Human2.20884598
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.19817984
16MAF_26560356_Chip-Seq_TH2_Human2.17598114
17* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.17323903
18P68_20966046_ChIP-Seq_HELA_Human2.17019553
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09378019
20UTX_26944678_Chip-Seq_JUKART_Human2.07847923
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04560230
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01911977
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.95568870
24BCL6_27268052_Chip-Seq_Bcells_Human1.95560062
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89817833
26BCOR_27268052_Chip-Seq_Bcells_Human1.82702531
27SA1_27219007_Chip-Seq_ERYTHROID_Human1.81406606
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80550056
29RACK7_27058665_Chip-Seq_MCF-7_Human1.79959807
30CTCF_27219007_Chip-Seq_ERYTHROID_Human1.78946318
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76534642
32SCL_19346495_ChIP-Seq_HPC-7_Human1.76328652
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.76191963
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72386738
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.69442976
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.66603015
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65345942
38SMC4_20622854_ChIP-Seq_HELA_Human1.65064049
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62767141
40KDM2B_26808549_Chip-Seq_K562_Human1.61987394
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.59511575
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56046207
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.55609195
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53233384
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49529997
46CTCF_27219007_Chip-Seq_Bcells_Human1.48917003
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46350812
48E2F1_20622854_ChIP-Seq_HELA_Human1.45176476
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44700848
50SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.44536151
51NCOR1_26117541_ChIP-Seq_K562_Human1.43802707
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43512625
53PHF8_20622854_ChIP-Seq_HELA_Human1.43429802
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.43205556
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42066792
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38733378
57CREB1_26743006_Chip-Seq_LNCaP_Human1.38646212
58SPI1_23127762_ChIP-Seq_K562_Human1.38632742
59MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.36058169
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35585088
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35403410
62SA1_27219007_Chip-Seq_Bcells_Human1.33983649
63GATA1_19941826_ChIP-Seq_K562_Human1.33845008
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33697121
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32158184
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32029651
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31315694
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30984922
69PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28047750
70CTCF_21964334_ChIP-Seq_BJAB-B_Human1.27989888
71CTCF_26484167_Chip-Seq_Bcells_Mouse1.26995290
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.26560983
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26167352
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25086937
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24603030
76SPI1_23547873_ChIP-Seq_NB4_Human1.22629664
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19051751
78CIITA_25753668_ChIP-Seq_RAJI_Human1.16452232
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15039232
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.14980790
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14590765
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14053498
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13985419
84CTCF_21964334_Chip-Seq_Bcells_Human1.13167538
85MYB_26560356_Chip-Seq_TH1_Human1.12557963
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12470503
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12124486
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11832765
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10002545
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09781554
91OCT4_19829295_ChIP-Seq_ESCs_Human1.09628429
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09145325
93TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08864282
94RARB_24833708_ChIP-Seq_LIVER_Mouse1.08195337
95CTCF_20526341_ChIP-Seq_ESCs_Human1.08145832
96DROSHA_22980978_ChIP-Seq_HELA_Human1.07863181
97TP63_22573176_ChIP-Seq_HFKS_Human1.06861541
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05429924
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05156849
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05107768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.08108572
2MP0003303_peritoneal_inflammation3.35887636
3MP0005058_abnormal_lysosome_morphology2.76290920
4MP0003172_abnormal_lysosome_physiology2.67870085
5MP0009278_abnormal_bone_marrow2.61357169
6MP0001800_abnormal_humoral_immune2.59916926
7MP0005025_abnormal_response_to2.59376532
8MP0003724_increased_susceptibility_to2.58302464
9MP0005387_immune_system_phenotype2.57926971
10MP0001790_abnormal_immune_system2.57926971
11MP0005671_abnormal_response_to2.56940073
12MP0001835_abnormal_antigen_presentation2.55847408
13MP0000685_abnormal_immune_system2.47133879
14MP0002419_abnormal_innate_immunity2.41070458
15MP0005000_abnormal_immune_tolerance2.38469370
16MP0002723_abnormal_immune_serum2.31700491
17MP0003763_abnormal_thymus_physiology2.31526738
18MP0001986_abnormal_taste_sensitivity2.23593538
19MP0002420_abnormal_adaptive_immunity2.22759077
20MP0001819_abnormal_immune_cell2.21092524
21MP0002452_abnormal_antigen_presenting2.14493699
22MP0009333_abnormal_splenocyte_physiolog2.09179716
23MP0010155_abnormal_intestine_physiology2.04520500
24MP0009379_abnormal_foot_pigmentation2.01802204
25MP0001873_stomach_inflammation2.01749343
26MP0009785_altered_susceptibility_to1.95870353
27MP0005464_abnormal_platelet_physiology1.91967467
28MP0004947_skin_inflammation1.89683784
29MP0002148_abnormal_hypersensitivity_rea1.88377335
30MP0004381_abnormal_hair_follicle1.86943060
31MP0002398_abnormal_bone_marrow1.86629798
32MP0000716_abnormal_immune_system1.78511944
33MP0002405_respiratory_system_inflammati1.77117017
34MP0002933_joint_inflammation1.64285230
35MP0001533_abnormal_skeleton_physiology1.60480002
36MP0008260_abnormal_autophagy1.60094803
37MP0003866_abnormal_defecation1.58771717
38MP0005397_hematopoietic_system_phenotyp1.58181797
39MP0001545_abnormal_hematopoietic_system1.58181797
40MP0003183_abnormal_peptide_metabolism1.52150638
41MP0002429_abnormal_blood_cell1.50517340
42MP0002722_abnormal_immune_system1.49329379
43MP0000689_abnormal_spleen_morphology1.48684227
44MP0006082_CNS_inflammation1.46091854
45MP0005083_abnormal_biliary_tract1.45068767
46MP0001845_abnormal_inflammatory_respons1.44701748
47MP0003300_gastrointestinal_ulcer1.44366800
48MP0000703_abnormal_thymus_morphology1.42601324
49MP0001663_abnormal_digestive_system1.31678556
50MP0002138_abnormal_hepatobiliary_system1.30104125
51MP0009840_abnormal_foam_cell1.29926662
52MP0005409_darkened_coat_color1.27719384
53MP0005174_abnormal_tail_pigmentation1.22575836
54MP0000465_gastrointestinal_hemorrhage1.21753706
55MP0004510_myositis1.20688877
56MP0004130_abnormal_muscle_cell1.19336762
57MP0005076_abnormal_cell_differentiation1.16610244
58MP0008469_abnormal_protein_level1.16520031
59MP0003879_abnormal_hair_cell1.14526721
60MP0002249_abnormal_larynx_morphology1.09260154
61MP0009764_decreased_sensitivity_to1.09084747
62MP0004858_abnormal_nervous_system1.08760280
63MP0002396_abnormal_hematopoietic_system1.08415544
64MP0005451_abnormal_body_composition1.08180975
65MP0002998_abnormal_bone_remodeling1.08174058
66MP0001849_ear_inflammation1.08152849
67MP0000015_abnormal_ear_pigmentation1.07967218
68MP0005423_abnormal_somatic_nervous1.03181498
69MP0003191_abnormal_cellular_cholesterol1.02649998
70MP0000858_altered_metastatic_potential1.02510143
71MP0004185_abnormal_adipocyte_glucose0.98841225
72MP0003453_abnormal_keratinocyte_physiol0.97894151
73MP0003705_abnormal_hypodermis_morpholog0.97101830
74MP0000678_abnormal_parathyroid_gland0.94687612
75MP0003878_abnormal_ear_physiology0.92803158
76MP0005377_hearing/vestibular/ear_phenot0.92803158
77MP0002132_abnormal_respiratory_system0.92418948
78MP0003828_pulmonary_edema0.86211158
79MP0000604_amyloidosis0.85867077
80MP0005381_digestive/alimentary_phenotyp0.85751746
81MP0005666_abnormal_adipose_tissue0.85642944
82MP0000490_abnormal_crypts_of0.85577779
83MP0003329_amyloid_beta_deposits0.82844653
84MP0003136_yellow_coat_color0.80966637
85MP0001765_abnormal_ion_homeostasis0.79484210
86MP0005535_abnormal_body_temperature0.78437206
87MP0008874_decreased_physiological_sensi0.73708030
88MP0001502_abnormal_circadian_rhythm0.72382909
89MP0005390_skeleton_phenotype0.71988604
90MP0005310_abnormal_salivary_gland0.71768254
91MP0001188_hyperpigmentation0.71289807
92MP0005375_adipose_tissue_phenotype0.70464964
93MP0002822_catalepsy0.68744097
94MP0003656_abnormal_erythrocyte_physiolo0.66473947
95MP0001348_abnormal_lacrimal_gland0.66392952
96MP0002653_abnormal_ependyma_morphology0.66050256
97MP0004808_abnormal_hematopoietic_stem0.64722272
98MP0009931_abnormal_skin_appearance0.64663583
99MP0002136_abnormal_kidney_physiology0.59436510
100MP0002019_abnormal_tumor_incidence0.55565515

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.79136089
2Obstructive lung disease (HP:0006536)3.63438656
3Chronic obstructive pulmonary disease (HP:0006510)3.63438656
4Recurrent abscess formation (HP:0002722)3.62418338
5Recurrent bacterial skin infections (HP:0005406)3.62398266
6Thin bony cortex (HP:0002753)3.56520601
7Abnormality of macrophages (HP:0004311)3.52361648
8Myositis (HP:0100614)3.52092851
9Colitis (HP:0002583)3.44595289
10Elevated erythrocyte sedimentation rate (HP:0003565)3.36724206
11Mediastinal lymphadenopathy (HP:0100721)3.34040362
12Prolonged bleeding time (HP:0003010)3.30986842
13Recurrent fungal infections (HP:0002841)3.24117702
14Gastrointestinal infarctions (HP:0005244)3.19592050
15Meningitis (HP:0001287)3.17127500
16Increased IgE level (HP:0003212)3.11508726
17Panhypogammaglobulinemia (HP:0003139)3.08131211
18Pustule (HP:0200039)3.06925788
19Gastrointestinal inflammation (HP:0004386)3.05558060
20Annular pancreas (HP:0001734)2.98215428
21Abnormal delayed hypersensitivity skin test (HP:0002963)2.89657260
22Orchitis (HP:0100796)2.87912596
23Inflammation of the large intestine (HP:0002037)2.87671340
24Chronic mucocutaneous candidiasis (HP:0002728)2.87627337
25Recurrent cutaneous fungal infections (HP:0011370)2.87627337
26Dysostosis multiplex (HP:0000943)2.83171399
27Cellulitis (HP:0100658)2.79273576
28Purpura (HP:0000979)2.76528902
29Obstructive sleep apnea (HP:0002870)2.70522682
30Encephalitis (HP:0002383)2.67541063
31Hemorrhage of the eye (HP:0011885)2.65047140
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.64628401
33Increased cerebral lipofuscin (HP:0011813)2.61855029
34Abnormality of the fingertips (HP:0001211)2.60433808
35Malnutrition (HP:0004395)2.58209612
36Recurrent skin infections (HP:0001581)2.57621834
37Petechiae (HP:0000967)2.57223452
38Increased serum ferritin (HP:0003281)2.54613986
39Gingivitis (HP:0000230)2.54199298
40Agammaglobulinemia (HP:0004432)2.52990645
41Hypochromic anemia (HP:0001931)2.52244757
42Retrobulbar optic neuritis (HP:0100654)2.51466465
43Optic neuritis (HP:0100653)2.51466465
44Hypertensive crisis (HP:0100735)2.48668766
45Recurrent gram-negative bacterial infections (HP:0005420)2.48617412
46Epistaxis (HP:0000421)2.48047278
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.46777437
48Recurrent viral infections (HP:0004429)2.44948755
49Abnormality of cells of the erythroid lineage (HP:0012130)2.40370497
50Vasculitis (HP:0002633)2.38762849
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35142973
52Stomatitis (HP:0010280)2.33304310
53Joint stiffness (HP:0001387)2.33133293
54Spontaneous hematomas (HP:0007420)2.32886496
55Chest pain (HP:0100749)2.31788297
56Emphysema (HP:0002097)2.31357187
57Abnormal number of erythroid precursors (HP:0012131)2.27136061
58Thoracic kyphosis (HP:0002942)2.24914943
59Hemoptysis (HP:0002105)2.24862331
60Myopathic facies (HP:0002058)2.23988962
61Easy fatigability (HP:0003388)2.20660625
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17206192
63Abnormality of polysaccharide metabolism (HP:0011012)2.17206192
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17206192
65Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15593079
66Seborrheic dermatitis (HP:0001051)2.11591920
67Urinary glycosaminoglycan excretion (HP:0003541)2.10244713
68Mucopolysacchariduria (HP:0008155)2.10244713
69Metaphyseal cupping (HP:0003021)2.09772655
70J-shaped sella turcica (HP:0002680)2.05183231
71Abnormality of iron homeostasis (HP:0011031)2.04822221
72Gastrointestinal stroma tumor (HP:0100723)2.04730030
73Systemic lupus erythematosus (HP:0002725)2.03338590
74Granulocytopenia (HP:0001913)2.02225248
75Thrombocytosis (HP:0001894)2.01404759
76Abnormality of the thoracic spine (HP:0100711)2.01386650
77Broad face (HP:0000283)1.98891295
78Pulmonary infiltrates (HP:0002113)1.97026750
79Impaired platelet aggregation (HP:0003540)1.94493112
80Abnormal platelet function (HP:0011869)1.94493112
81Nasal polyposis (HP:0100582)1.92831501
82Increased IgM level (HP:0003496)1.91948300
83Abnormality of the nasal mucosa (HP:0000433)1.90758790
84Rib fusion (HP:0000902)1.90604995
85Reticulocytosis (HP:0001923)1.88959860
86Abnormality of glycolipid metabolism (HP:0010969)1.86619312
87Abnormality of liposaccharide metabolism (HP:0010968)1.86619312
88Abnormality of glycosphingolipid metabolism (HP:0004343)1.86619312
89Hypertriglyceridemia (HP:0002155)1.86602253
90Pallor (HP:0000980)1.86552265
91Restrictive lung disease (HP:0002091)1.80996903
92Hypophosphatemia (HP:0002148)1.79738767
93Spinal canal stenosis (HP:0003416)1.79524942
94Acne (HP:0001061)1.77229691
95Urticaria (HP:0001025)1.76991493
96Truncus arteriosus (HP:0001660)1.73736168
97Keratoconjunctivitis sicca (HP:0001097)1.73078078
98Segmental peripheral demyelination/remyelination (HP:0003481)1.72352081
99Lymphopenia (HP:0001888)1.71971459
100Hyperthyroidism (HP:0000836)1.71462453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.36756219
2TRIB33.30296362
3RIPK43.05033762
4ERN13.00705794
5SIK12.51561347
6SIK22.37650719
7BLK2.25175400
8MAP2K32.22541370
9PRPF4B2.16298529
10TNK22.03475074
11GRK61.95180845
12MAP3K111.93153435
13BTK1.80336560
14MARK21.73848171
15FES1.72379961
16ZAP701.67085841
17TYK21.66157223
18TBK11.60928296
19MAPK151.58794371
20IRAK41.52237616
21CSK1.45323921
22MAP3K131.44925750
23PRKD21.38633122
24TESK21.35279456
25SYK1.31082556
26MAP3K71.29743105
27SMG11.29609283
28ICK1.26438819
29TXK1.25579020
30MAP2K61.25477259
31MAP3K141.23974935
32MAP3K101.23933985
33CDC42BPA1.20297579
34IKBKE1.17068658
35RPS6KL11.16241074
36RPS6KC11.16241074
37JAK31.13742266
38IKBKB1.12981497
39MATK1.09946393
40EEF2K1.09510690
41PTK61.09078617
42EPHB11.08756807
43TAOK11.05798346
44RPS6KA61.05105092
45SIK31.03180132
46MAP2K21.02975038
47RPS6KA21.01758029
48DYRK1B1.01195536
49HCK1.00906693
50RIPK11.00083565
51TLK10.98969499
52MAP3K10.98359032
53FGFR40.97212336
54MAPK120.96863807
55LYN0.95765321
56BMX0.95353735
57ITK0.94772974
58MAP3K60.93297614
59NME20.91348369
60TYRO30.91346474
61LCK0.90195174
62PKN20.89117609
63TAOK30.88719560
64KIT0.86746525
65TAOK20.85124841
66HIPK20.81653592
67CSF1R0.77345452
68MARK30.75012888
69PDPK10.74850803
70IRAK30.73096236
71CAMKK10.71003477
72WNK40.70673482
73CDK40.68559184
74JAK20.67484501
75CDK120.67287586
76MAPK70.65520963
77MAP3K30.65438969
78JAK10.62871278
79KDR0.61599112
80FGR0.60534262
81MAPK110.58464907
82PDK10.56792092
83PRKCQ0.55986683
84PRKCH0.55550563
85MST1R0.55029217
86MAP2K40.52070950
87MTOR0.51306735
88LRRK20.49726074
89TEC0.49395149
90PIM20.48817348
91FYN0.47937792
92PIM10.46656027
93IRAK20.46591998
94RET0.46387829
95CHUK0.46235265
96MAPK40.44488727
97RPS6KA10.44148838
98STK110.42592189
99MAPK30.42178587
100DDR20.41501548

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.26361365
2Osteoclast differentiation_Homo sapiens_hsa043802.23497400
3B cell receptor signaling pathway_Homo sapiens_hsa046622.20611078
4Primary immunodeficiency_Homo sapiens_hsa053402.20386205
5Leishmaniasis_Homo sapiens_hsa051402.10873773
6Allograft rejection_Homo sapiens_hsa053302.02938755
7Notch signaling pathway_Homo sapiens_hsa043301.95622541
8Graft-versus-host disease_Homo sapiens_hsa053321.93915162
9Staphylococcus aureus infection_Homo sapiens_hsa051501.91379299
10Autoimmune thyroid disease_Homo sapiens_hsa053201.87959079
11Acute myeloid leukemia_Homo sapiens_hsa052211.86135147
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79243322
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.72903137
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71016957
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.69149287
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67544563
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.61220526
18VEGF signaling pathway_Homo sapiens_hsa043701.54620205
19T cell receptor signaling pathway_Homo sapiens_hsa046601.53305952
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48309006
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48282312
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46017817
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45489559
24Tuberculosis_Homo sapiens_hsa051521.44470870
25Asthma_Homo sapiens_hsa053101.44454343
26Sulfur relay system_Homo sapiens_hsa041221.41673569
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34727353
28Type I diabetes mellitus_Homo sapiens_hsa049401.31981629
29Hematopoietic cell lineage_Homo sapiens_hsa046401.29596333
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24017633
31Toxoplasmosis_Homo sapiens_hsa051451.22792521
32Influenza A_Homo sapiens_hsa051641.21908068
33Antigen processing and presentation_Homo sapiens_hsa046121.21399764
34TNF signaling pathway_Homo sapiens_hsa046681.19751990
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15686405
36Chemokine signaling pathway_Homo sapiens_hsa040621.13417218
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12489876
38Herpes simplex infection_Homo sapiens_hsa051681.11732165
39Non-small cell lung cancer_Homo sapiens_hsa052231.10941946
40Chronic myeloid leukemia_Homo sapiens_hsa052201.10620704
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08848477
42Fructose and mannose metabolism_Homo sapiens_hsa000511.08050490
43Viral myocarditis_Homo sapiens_hsa054161.04712623
44Lysosome_Homo sapiens_hsa041421.03726529
45Malaria_Homo sapiens_hsa051441.01176674
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.01137236
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.00883665
48Measles_Homo sapiens_hsa051620.98449107
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.97214793
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.96765903
51GnRH signaling pathway_Homo sapiens_hsa049120.96698173
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.96427233
53Platelet activation_Homo sapiens_hsa046110.96248934
54Hepatitis C_Homo sapiens_hsa051600.95800624
55Hepatitis B_Homo sapiens_hsa051610.92930477
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91735091
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.83457609
58Endocytosis_Homo sapiens_hsa041440.82880259
59Choline metabolism in cancer_Homo sapiens_hsa052310.82312121
60Apoptosis_Homo sapiens_hsa042100.81084308
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80437189
62Pertussis_Homo sapiens_hsa051330.80300811
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78288674
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78283068
65Pancreatic cancer_Homo sapiens_hsa052120.76706676
66Rheumatoid arthritis_Homo sapiens_hsa053230.75564887
67mTOR signaling pathway_Homo sapiens_hsa041500.75490587
68MAPK signaling pathway_Homo sapiens_hsa040100.75145734
69Bladder cancer_Homo sapiens_hsa052190.73521598
70Prolactin signaling pathway_Homo sapiens_hsa049170.73222043
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73045636
72Viral carcinogenesis_Homo sapiens_hsa052030.72523685
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71146346
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.69977156
75Salmonella infection_Homo sapiens_hsa051320.69508536
76Epstein-Barr virus infection_Homo sapiens_hsa051690.67061082
77HTLV-I infection_Homo sapiens_hsa051660.66785075
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66292093
79Inositol phosphate metabolism_Homo sapiens_hsa005620.64307174
80Phagosome_Homo sapiens_hsa041450.64181016
81Insulin resistance_Homo sapiens_hsa049310.63029785
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61912389
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59180428
84Shigellosis_Homo sapiens_hsa051310.57350780
85ErbB signaling pathway_Homo sapiens_hsa040120.55480924
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55242020
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53457827
88Systemic lupus erythematosus_Homo sapiens_hsa053220.53345348
89Insulin signaling pathway_Homo sapiens_hsa049100.47648485
90African trypanosomiasis_Homo sapiens_hsa051430.46380496
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45399533
92Type II diabetes mellitus_Homo sapiens_hsa049300.43120363
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42422621
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42273087
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40311895
96FoxO signaling pathway_Homo sapiens_hsa040680.40157316
97Renal cell carcinoma_Homo sapiens_hsa052110.39966255
98ABC transporters_Homo sapiens_hsa020100.39435164
99Ribosome_Homo sapiens_hsa030100.39240645
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.37951159

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