WASL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.07931056
2glutamate secretion (GO:0014047)3.83518866
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.78781913
4locomotory exploration behavior (GO:0035641)3.69319516
5vocalization behavior (GO:0071625)3.61391578
6desmosome organization (GO:0002934)3.51010092
7neuronal action potential propagation (GO:0019227)3.42182550
8synaptic vesicle exocytosis (GO:0016079)3.41889193
9synaptic vesicle maturation (GO:0016188)3.36326335
10regulation of synaptic vesicle exocytosis (GO:2000300)3.27439161
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.22942072
12bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14930876
13regulation of long-term neuronal synaptic plasticity (GO:0048169)3.14055957
14regulation of neuronal synaptic plasticity (GO:0048168)3.13469512
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.09118697
16paraxial mesoderm development (GO:0048339)3.05066583
17negative regulation of hormone metabolic process (GO:0032351)3.04698791
18negative regulation of hormone biosynthetic process (GO:0032353)3.04698791
19regulation of synaptic vesicle transport (GO:1902803)3.00811197
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.00076304
21regulation of glutamate receptor signaling pathway (GO:1900449)2.97835516
22synaptic vesicle docking involved in exocytosis (GO:0016081)2.96338284
23neurotransmitter secretion (GO:0007269)2.96072230
24glutamate receptor signaling pathway (GO:0007215)2.94040279
25exploration behavior (GO:0035640)2.92803554
26synaptic transmission, glutamatergic (GO:0035249)2.88306754
27layer formation in cerebral cortex (GO:0021819)2.87533507
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78083644
29neuron-neuron synaptic transmission (GO:0007270)2.77443190
30cytoskeletal anchoring at plasma membrane (GO:0007016)2.76146159
31protein localization to synapse (GO:0035418)2.75114361
32innervation (GO:0060384)2.74494211
33cellular potassium ion homeostasis (GO:0030007)2.73179475
34L-phenylalanine catabolic process (GO:0006559)2.69693845
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.69693845
36regulation of transforming growth factor beta2 production (GO:0032909)2.67790911
37neuron recognition (GO:0008038)2.67677675
38positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.65974725
39dendritic spine morphogenesis (GO:0060997)2.65906435
40notochord development (GO:0030903)2.63740839
41protein targeting to Golgi (GO:0000042)2.63335895
42neuron cell-cell adhesion (GO:0007158)2.63156980
43axonal fasciculation (GO:0007413)2.62367302
44gamma-aminobutyric acid transport (GO:0015812)2.61264706
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60263898
46regulation of synaptic plasticity (GO:0048167)2.58954554
47regulation of dendritic spine morphogenesis (GO:0061001)2.58515778
48apical protein localization (GO:0045176)2.57802980
49cerebellar granule cell differentiation (GO:0021707)2.56590221
50proline transport (GO:0015824)2.56065010
51negative regulation of dendrite morphogenesis (GO:0050774)2.55337751
52long-term synaptic potentiation (GO:0060291)2.55086258
53cell communication by electrical coupling (GO:0010644)2.54910770
54drug catabolic process (GO:0042737)2.54873872
55neuromuscular process controlling posture (GO:0050884)2.53680162
56glutamate metabolic process (GO:0006536)2.52711951
57behavioral fear response (GO:0001662)2.51881918
58behavioral defense response (GO:0002209)2.51881918
59synaptic vesicle endocytosis (GO:0048488)2.51600028
60cerebellar Purkinje cell differentiation (GO:0021702)2.50751272
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.50320244
62L-phenylalanine metabolic process (GO:0006558)2.50320244
63gap junction assembly (GO:0016264)2.49607263
64neurotransmitter transport (GO:0006836)2.47799526
65chemosensory behavior (GO:0007635)2.46474824
66cysteine metabolic process (GO:0006534)2.46116601
67sodium ion export (GO:0071436)2.45518239
68long-term memory (GO:0007616)2.45206868
69lysine catabolic process (GO:0006554)2.44556321
70lysine metabolic process (GO:0006553)2.44556321
71embryonic retina morphogenesis in camera-type eye (GO:0060059)2.40897984
72dendritic spine organization (GO:0097061)2.40685788
73regulation of excitatory postsynaptic membrane potential (GO:0060079)2.40396987
74fear response (GO:0042596)2.37983645
75gamma-aminobutyric acid signaling pathway (GO:0007214)2.37730989
76regulation of sodium ion transmembrane transporter activity (GO:2000649)2.37352275
77regulation of Rac protein signal transduction (GO:0035020)2.36650764
78dicarboxylic acid biosynthetic process (GO:0043650)2.36014244
79cell migration in hindbrain (GO:0021535)2.35862529
80negative regulation of keratinocyte proliferation (GO:0010839)2.34772634
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.34014462
82neurotransmitter-gated ion channel clustering (GO:0072578)2.33716405
83neuromuscular process controlling balance (GO:0050885)2.32661925
84activation of protein kinase A activity (GO:0034199)2.32183664
85establishment of protein localization to Golgi (GO:0072600)2.31980839
86regulation of vesicle fusion (GO:0031338)2.31898083
87regulation of neurotransmitter levels (GO:0001505)2.31052610
88regulation of postsynaptic membrane potential (GO:0060078)2.30110826
89membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.30100028
90positive regulation of synapse maturation (GO:0090129)2.29694898
91regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.29529483
92neurotransmitter catabolic process (GO:0042135)2.28986225
93* regulation of clathrin-mediated endocytosis (GO:2000369)2.28819791
94regulation of female receptivity (GO:0045924)2.28519379
95long term synaptic depression (GO:0060292)2.28388352
96potassium ion homeostasis (GO:0055075)2.28106850
97regulation of bile acid biosynthetic process (GO:0070857)2.27735809
98receptor recycling (GO:0001881)2.26213068
99cellular glucuronidation (GO:0052695)2.25813564
100ephrin receptor signaling pathway (GO:0048013)2.25610570
101negative regulation of dendrite development (GO:2000171)2.25518062
102transmission of nerve impulse (GO:0019226)2.24382210
103cellular sodium ion homeostasis (GO:0006883)2.24218467
104hemidesmosome assembly (GO:0031581)2.23854165
105suckling behavior (GO:0001967)2.23475708
106maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.22620706
107vesicle transport along microtubule (GO:0047496)2.22434189
108cell communication involved in cardiac conduction (GO:0086065)2.21903849
109positive regulation of vesicle fusion (GO:0031340)2.19924936
110sodium ion homeostasis (GO:0055078)2.19082566
111negative regulation of sodium ion transport (GO:0010766)2.18598348
112aromatic amino acid family catabolic process (GO:0009074)2.17311479
113protein retention in ER lumen (GO:0006621)2.17164346
114phosphate ion transmembrane transport (GO:0035435)2.16549729
115regulation of cardioblast differentiation (GO:0051890)2.15860436
116female mating behavior (GO:0060180)2.15835941
117positive regulation of sodium ion transport (GO:0010765)2.15749913
118regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.15379594
119membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.14866737
120COPII vesicle coating (GO:0048208)2.14825776
121exogenous drug catabolic process (GO:0042738)2.13991084
122dendrite morphogenesis (GO:0048813)2.13379152
123regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.13321274
124neuromuscular process (GO:0050905)2.12904203
125hippo signaling (GO:0035329)2.12717286
126asymmetric protein localization (GO:0008105)2.11698061
127COPI coating of Golgi vesicle (GO:0048205)2.10419610
128Golgi transport vesicle coating (GO:0048200)2.10419610
129amino acid import (GO:0043090)2.09888285
130embryonic foregut morphogenesis (GO:0048617)2.06997325
131anterior/posterior axis specification, embryo (GO:0008595)2.05664151
132glucuronate metabolic process (GO:0019585)2.02968511
133uronic acid metabolic process (GO:0006063)2.02968511
134positive regulation of p38MAPK cascade (GO:1900745)2.02824733
135regulation of cholesterol homeostasis (GO:2000188)2.02126950
136intestinal epithelial cell development (GO:0060576)2.01068925
137midgut development (GO:0007494)1.99122827
138cell adhesion mediated by integrin (GO:0033627)1.94635566
139cell-cell junction assembly (GO:0007043)1.93618411
140cerebellar Purkinje cell layer development (GO:0021680)1.89840016
141regulation of steroid hormone biosynthetic process (GO:0090030)1.87389894
142tight junction assembly (GO:0070830)1.86308346
143positive regulation of glucose transport (GO:0010828)1.86021678
144regulation of glucocorticoid metabolic process (GO:0031943)1.84974991
145potassium ion import (GO:0010107)1.83218626
146vesicle coating (GO:0006901)1.82918131
147regulation of transforming growth factor beta1 production (GO:0032908)1.82311092
148phosphate ion transport (GO:0006817)1.81640386
149detection of calcium ion (GO:0005513)1.80953452
150skin morphogenesis (GO:0043589)1.79971065
151regulation of heart rate by cardiac conduction (GO:0086091)1.79908456
152epithelial cell-cell adhesion (GO:0090136)1.79855545
153intestinal absorption (GO:0050892)1.79366017
154mating behavior (GO:0007617)1.78713918
155ventricular cardiac muscle cell action potential (GO:0086005)1.78513101
156actin filament depolymerization (GO:0030042)1.78337985
157cardiac conduction (GO:0061337)1.75023129
158positive regulation of glycoprotein metabolic process (GO:1903020)1.74983837
159positive regulation of glucose import (GO:0046326)1.74937422
160regulation of keratinocyte proliferation (GO:0010837)1.74819572
161regulation of cell communication by electrical coupling (GO:0010649)1.73860327
162multicellular organismal water homeostasis (GO:0050891)1.73788211
163regulation of epidermal growth factor-activated receptor activity (GO:0007176)1.73534088
164calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)1.73171548
165ectodermal placode formation (GO:0060788)1.72240013
166presynaptic membrane assembly (GO:0097105)1.71898008
167renal system process involved in regulation of blood volume (GO:0001977)1.71519544
168membrane assembly (GO:0071709)1.71302920
169regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.70069384
170planar cell polarity pathway involved in neural tube closure (GO:0090179)1.69266732
171regulation of p38MAPK cascade (GO:1900744)1.69247498
172negative regulation of chondrocyte differentiation (GO:0032331)1.69233975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.71679819
2GBX2_23144817_ChIP-Seq_PC3_Human2.93916765
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.79405686
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39410732
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36503003
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.33803127
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.33075533
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24149313
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19060334
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17462357
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17462357
12CLOCK_20551151_ChIP-Seq_293T_Human2.00012916
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99836761
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95479091
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94500484
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.91451998
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88295281
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87608600
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.86015774
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85519626
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83098254
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80475872
23AR_21909140_ChIP-Seq_LNCAP_Human1.77525706
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.76983556
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.76285259
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72169035
27REST_21632747_ChIP-Seq_MESCs_Mouse1.71369866
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.70852603
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.69720222
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66745808
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65208910
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63546348
33SMAD4_21799915_ChIP-Seq_A2780_Human1.61329469
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57443980
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57020068
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.55775329
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54342896
38TAF15_26573619_Chip-Seq_HEK293_Human1.53822397
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.51966981
40DROSHA_22980978_ChIP-Seq_HELA_Human1.50472210
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47789032
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45616717
43* SOX2_20726797_ChIP-Seq_SW620_Human1.43223287
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.42329801
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41008460
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40982532
47* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40812114
48* RXR_22158963_ChIP-Seq_LIVER_Mouse1.40340696
49* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39041772
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38256652
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.37741416
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.37013731
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.36580727
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35498760
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35269569
56LXR_22158963_ChIP-Seq_LIVER_Mouse1.34567388
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.34561466
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34484398
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.34385503
60BCAT_22108803_ChIP-Seq_LS180_Human1.33554572
61P300_19829295_ChIP-Seq_ESCs_Human1.32935836
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31566051
63* STAT3_23295773_ChIP-Seq_U87_Human1.30297043
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30167301
65ZNF263_19887448_ChIP-Seq_K562_Human1.28275557
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.26763322
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26642381
68* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26575007
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26228680
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25764957
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.25635135
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25512483
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23812052
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22027547
75TP53_16413492_ChIP-PET_HCT116_Human1.21536368
76AR_21572438_ChIP-Seq_LNCaP_Human1.19230406
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18478025
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.18418873
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.18135881
80* AR_19668381_ChIP-Seq_PC3_Human1.17566757
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17530947
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16451064
83RXR_22108803_ChIP-Seq_LS180_Human1.15985292
84* CJUN_26792858_Chip-Seq_BT549_Human1.15671992
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14749940
86* ARNT_22903824_ChIP-Seq_MCF-7_Human1.14410866
87VDR_22108803_ChIP-Seq_LS180_Human1.14303394
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13087082
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13027013
90* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12004558
91AR_25329375_ChIP-Seq_VCAP_Human1.11182510
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11157602
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.11076015
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10906844
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10613894
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.10128014
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08836759
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08832673
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08342312
100* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08226741
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08089361
102IGF1R_20145208_ChIP-Seq_DFB_Human1.07871055
103* AHR_22903824_ChIP-Seq_MCF-7_Human1.07684289
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06633871
105* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06521624
106CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06487101
107SMAD4_21741376_ChIP-Seq_HESCs_Human1.05530442
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.05375992
109SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04462353
110FUS_26573619_Chip-Seq_HEK293_Human1.04455582
111ISL1_27105846_Chip-Seq_CPCs_Mouse1.03710889
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03304427
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02718367
114* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02664473
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02480330
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01810785
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01634938
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01197192
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00853024
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00830207
121SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00512589
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.99205108
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98604397
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98604397
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98403209
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98403209
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97817325
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97614050
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.97416709
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97042111
131* TCF4_23295773_ChIP-Seq_U87_Human0.96483344
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96342707
133CBX2_27304074_Chip-Seq_ESCs_Mouse0.96130010
134TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95801294
135* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95489396
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95371841
137* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95367797
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95249749
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95060339
140* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94867756
141TP53_18474530_ChIP-ChIP_U2OS_Human0.94764194
142ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91906978
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91723922
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90864832
145ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90821735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.72698205
2MP0004270_analgesia3.36786089
3MP0003880_abnormal_central_pattern3.29056373
4MP0005360_urolithiasis3.10828459
5MP0002139_abnormal_hepatobiliary_system2.98579470
6MP0003635_abnormal_synaptic_transmissio2.93304943
7MP0003941_abnormal_skin_development2.60155625
8MP0002063_abnormal_learning/memory/cond2.38602042
9MP0005085_abnormal_gallbladder_physiolo2.38577516
10MP0010352_gastrointestinal_tract_polyps2.36448046
11MP0010234_abnormal_vibrissa_follicle2.31409529
12MP0009745_abnormal_behavioral_response2.26213162
13MP0004272_abnormal_basement_membrane2.13390573
14MP0005365_abnormal_bile_salt2.11370013
15MP0002064_seizures2.07169288
16MP0009780_abnormal_chondrocyte_physiolo2.06787158
17MP0000566_synostosis1.96005375
18MP0008875_abnormal_xenobiotic_pharmacok1.95119442
19MP0002572_abnormal_emotion/affect_behav1.90692098
20MP0001968_abnormal_touch/_nociception1.88308880
21MP0002734_abnormal_mechanical_nocicepti1.76644959
22MP0003705_abnormal_hypodermis_morpholog1.76452300
23MP0009046_muscle_twitch1.75773644
24MP0001501_abnormal_sleep_pattern1.72089509
25MP0002796_impaired_skin_barrier1.71762466
26MP0003123_paternal_imprinting1.71056206
27MP0005409_darkened_coat_color1.70060394
28MP0001486_abnormal_startle_reflex1.69159217
29MP0003252_abnormal_bile_duct1.68731128
30MP0003329_amyloid_beta_deposits1.67794507
31MP0002272_abnormal_nervous_system1.64826384
32MP0001440_abnormal_grooming_behavior1.62821778
33MP0010678_abnormal_skin_adnexa1.59368954
34MP0003195_calcinosis1.50847116
35MP0006276_abnormal_autonomic_nervous1.48501125
36MP0003283_abnormal_digestive_organ1.48041888
37MP0002733_abnormal_thermal_nociception1.45197941
38MP0000778_abnormal_nervous_system1.42501988
39MP0002822_catalepsy1.42369748
40MP0002736_abnormal_nociception_after1.42329120
41MP0001299_abnormal_eye_distance/1.41627254
42MP0005257_abnormal_intraocular_pressure1.38148587
43MP0005275_abnormal_skin_tensile1.38103708
44MP0004043_abnormal_pH_regulation1.36526821
45MP0002837_dystrophic_cardiac_calcinosis1.35617942
46MP0000762_abnormal_tongue_morphology1.35307838
47MP0005332_abnormal_amino_acid1.32835165
48MP0002909_abnormal_adrenal_gland1.32419658
49MP0002735_abnormal_chemical_nociception1.31832642
50MP0002067_abnormal_sensory_capabilities1.28540257
51MP0003787_abnormal_imprinting1.26957797
52MP0008438_abnormal_cutaneous_collagen1.25015230
53MP0004885_abnormal_endolymph1.24208968
54MP0005248_abnormal_Harderian_gland1.23937084
55MP0004858_abnormal_nervous_system1.21238989
56MP0005646_abnormal_pituitary_gland1.21088990
57MP0003566_abnormal_cell_adhesion1.17741922
58MP0000751_myopathy1.17635648
59MP0001970_abnormal_pain_threshold1.16505736
60MP0005187_abnormal_penis_morphology1.14299468
61MP0002184_abnormal_innervation1.14065038
62MP0004924_abnormal_behavior1.13859578
63MP0005386_behavior/neurological_phenoty1.13859578
64MP0001529_abnormal_vocalization1.12107067
65MP0000955_abnormal_spinal_cord1.10051093
66MP0002557_abnormal_social/conspecific_i1.09385265
67MP0002653_abnormal_ependyma_morphology1.07620288
68MP0010329_abnormal_lipoprotein_level1.06686577
69MP0003879_abnormal_hair_cell1.06602606
70MP0008961_abnormal_basal_metabolism1.05401535
71MP0003868_abnormal_feces_composition1.04228099
72MP0002896_abnormal_bone_mineralization1.03514367
73MP0000003_abnormal_adipose_tissue1.01451656
74MP0005501_abnormal_skin_physiology0.97768943
75MP0002066_abnormal_motor_capabilities/c0.97719479
76MP0003122_maternal_imprinting0.95988233
77MP0000467_abnormal_esophagus_morphology0.95693495
78MP0001502_abnormal_circadian_rhythm0.94518732
79MP0002060_abnormal_skin_morphology0.93931589
80MP0004811_abnormal_neuron_physiology0.93700893
81MP0001188_hyperpigmentation0.93425752
82MP0001666_abnormal_nutrient_absorption0.93377047
83MP0000383_abnormal_hair_follicle0.92979998
84MP0003950_abnormal_plasma_membrane0.91209270
85MP0002697_abnormal_eye_size0.90923288
86MP0002882_abnormal_neuron_morphology0.90819508
87MP0003890_abnormal_embryonic-extraembry0.90112854
88MP0000462_abnormal_digestive_system0.89895912
89MP0002233_abnormal_nose_morphology0.88856613
90MP0001765_abnormal_ion_homeostasis0.87606209
91MP0002098_abnormal_vibrissa_morphology0.87236827
92MP0003937_abnormal_limbs/digits/tail_de0.87142043
93MP0004019_abnormal_vitamin_homeostasis0.85958884
94MP0001177_atelectasis0.85193892
95MP0008569_lethality_at_weaning0.84539275
96MP0010386_abnormal_urinary_bladder0.84393340
97MP0003385_abnormal_body_wall0.84268139
98MP0000013_abnormal_adipose_tissue0.83973298
99MP0004782_abnormal_surfactant_physiolog0.83700211
100MP0001849_ear_inflammation0.82195627
101MP0004145_abnormal_muscle_electrophysio0.81701545
102MP0008872_abnormal_physiological_respon0.81699266
103MP0002152_abnormal_brain_morphology0.81263497
104MP0005535_abnormal_body_temperature0.81180119
105MP0010368_abnormal_lymphatic_system0.80968191
106MP0005423_abnormal_somatic_nervous0.80635227
107MP0004264_abnormal_extraembryonic_tissu0.79357951
108MP0005670_abnormal_white_adipose0.78884136
109MP0003633_abnormal_nervous_system0.78311712
110MP0005623_abnormal_meninges_morphology0.78280833
111MP0009672_abnormal_birth_weight0.78099503
112MP0000639_abnormal_adrenal_gland0.77841582
113MP0000537_abnormal_urethra_morphology0.77179838
114MP0000647_abnormal_sebaceous_gland0.76991371
115MP0002069_abnormal_eating/drinking_beha0.76863244
116MP0002089_abnormal_postnatal_growth/wei0.75535196
117MP0000569_abnormal_digit_pigmentation0.75077036
118MP0003119_abnormal_digestive_system0.74773744
119MP0003631_nervous_system_phenotype0.74611649
120MP0000579_abnormal_nail_morphology0.71460174
121MP0002234_abnormal_pharynx_morphology0.70844707
122MP0002876_abnormal_thyroid_physiology0.70559954
123MP0002138_abnormal_hepatobiliary_system0.70463846
124MP0000377_abnormal_hair_follicle0.70077359
125MP0003453_abnormal_keratinocyte_physiol0.69966804
126MP0003115_abnormal_respiratory_system0.69585829
127MP0008874_decreased_physiological_sensi0.69536107
128MP0003755_abnormal_palate_morphology0.69468715
129MP0004215_abnormal_myocardial_fiber0.69431910
130MP0010771_integument_phenotype0.69318517
131MP0002118_abnormal_lipid_homeostasis0.69014305
132MP0006138_congestive_heart_failure0.68764083
133MP0004484_altered_response_of0.68504262
134MP0005023_abnormal_wound_healing0.68241577
135MP0001485_abnormal_pinna_reflex0.66826867
136MP0003632_abnormal_nervous_system0.66752003
137MP0009384_cardiac_valve_regurgitation0.65375748
138MP0002090_abnormal_vision0.65353310
139MP0005375_adipose_tissue_phenotype0.65262591
140MP0000538_abnormal_urinary_bladder0.65093285
141MP0004233_abnormal_muscle_weight0.65052819
142* MP0004085_abnormal_heartbeat0.64325809
143MP0003634_abnormal_glial_cell0.64125737
144MP0003935_abnormal_craniofacial_develop0.62685533
145MP0000534_abnormal_ureter_morphology0.61763145
146MP0003942_abnormal_urinary_system0.61521003
147MP0005084_abnormal_gallbladder_morpholo0.61487269
148MP0000432_abnormal_head_morphology0.61431455
149MP0001984_abnormal_olfaction0.60846204
150MP0002108_abnormal_muscle_morphology0.60536785
151* MP0002084_abnormal_developmental_patter0.60487499

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.74513423
2Myokymia (HP:0002411)4.06181688
3Focal seizures (HP:0007359)3.90906645
4Atonic seizures (HP:0010819)3.63978061
5Right ventricular cardiomyopathy (HP:0011663)3.48446154
6Hyperventilation (HP:0002883)3.11449406
7Action tremor (HP:0002345)3.04796527
8Visual hallucinations (HP:0002367)3.03664351
9Absence seizures (HP:0002121)2.97263118
10Febrile seizures (HP:0002373)2.96878480
11Epileptic encephalopathy (HP:0200134)2.89522388
12Progressive cerebellar ataxia (HP:0002073)2.83329019
13Gout (HP:0001997)2.82792500
14Generalized tonic-clonic seizures (HP:0002069)2.82678661
15Deep venous thrombosis (HP:0002625)2.82465769
16Abnormality of aromatic amino acid family metabolism (HP:0004338)2.63150892
17Hypoglycemic seizures (HP:0002173)2.59530669
18Dialeptic seizures (HP:0011146)2.59318972
19Dysdiadochokinesis (HP:0002075)2.56863382
20Intrahepatic cholestasis (HP:0001406)2.55594266
21Termporal pattern (HP:0011008)2.51323166
22Insidious onset (HP:0003587)2.51323166
23Abnormality of the lower motor neuron (HP:0002366)2.43975572
24Genetic anticipation (HP:0003743)2.43515784
25Increased circulating renin level (HP:0000848)2.42698799
26Dysmetria (HP:0001310)2.36799461
27Impaired vibration sensation in the lower limbs (HP:0002166)2.36723825
28Cerebral inclusion bodies (HP:0100314)2.36166078
29Drooling (HP:0002307)2.31496027
30Excessive salivation (HP:0003781)2.31496027
31Hyperinsulinemic hypoglycemia (HP:0000825)2.30536639
32Status epilepticus (HP:0002133)2.23568888
33Spontaneous abortion (HP:0005268)2.22936908
34Epileptiform EEG discharges (HP:0011182)2.22620723
35Abnormal social behavior (HP:0012433)2.22226733
36Impaired social interactions (HP:0000735)2.22226733
37Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13659827
38Amblyopia (HP:0000646)2.11567744
39EEG with generalized epileptiform discharges (HP:0011198)2.09727479
40Hepatoblastoma (HP:0002884)2.08016353
41Postural instability (HP:0002172)2.06321794
42Hyperactive renin-angiotensin system (HP:0000841)2.05376588
43Hypoglycemic coma (HP:0001325)2.05015155
44Neurofibrillary tangles (HP:0002185)2.03240785
45Gaze-evoked nystagmus (HP:0000640)2.01929993
46Ketoacidosis (HP:0001993)2.00637184
47Urinary bladder sphincter dysfunction (HP:0002839)2.00451280
48Hypsarrhythmia (HP:0002521)2.00055473
49Coronal craniosynostosis (HP:0004440)1.99087199
50Xanthomatosis (HP:0000991)1.96087608
51Shallow orbits (HP:0000586)1.95961023
52Scanning speech (HP:0002168)1.94654123
53Malnutrition (HP:0004395)1.94383876
54Thickened helices (HP:0000391)1.93808239
55Sensorimotor neuropathy (HP:0007141)1.93329461
56Vascular calcification (HP:0004934)1.93186748
57Broad-based gait (HP:0002136)1.92617141
58Hand muscle atrophy (HP:0009130)1.92176830
59Intention tremor (HP:0002080)1.91750169
60Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91698210
61Generalized myoclonic seizures (HP:0002123)1.89989922
62Bronchomalacia (HP:0002780)1.89906274
63Neonatal short-limb short stature (HP:0008921)1.89387765
64Poor eye contact (HP:0000817)1.88807991
65Ketosis (HP:0001946)1.87427280
66Impaired vibratory sensation (HP:0002495)1.85813651
67Confusion (HP:0001289)1.85206921
68Cardiovascular calcification (HP:0011915)1.84802017
69Anxiety (HP:0000739)1.84615730
70Upper limb amyotrophy (HP:0009129)1.84459282
71Distal upper limb amyotrophy (HP:0007149)1.84459282
72Hyperglycinemia (HP:0002154)1.82964569
73Symptomatic seizures (HP:0011145)1.82880046
74Vertebral arch anomaly (HP:0008438)1.81378377
75Ventricular fibrillation (HP:0001663)1.80370314
76Hypobetalipoproteinemia (HP:0003563)1.80307425
77Metabolic alkalosis (HP:0200114)1.79698079
78Turricephaly (HP:0000262)1.79655498
79Abnormality of the corticospinal tract (HP:0002492)1.78832108
80Fat malabsorption (HP:0002630)1.78773326
81Protrusio acetabuli (HP:0003179)1.78421137
82Blue irides (HP:0000635)1.77372903
83Megalencephaly (HP:0001355)1.77099922
84Hyperglycinuria (HP:0003108)1.76806333
85Dysmetric saccades (HP:0000641)1.76696392
86Potter facies (HP:0002009)1.76279536
87Facial shape deformation (HP:0011334)1.76279536
88Fair hair (HP:0002286)1.75056365
89Aplasia involving bones of the extremities (HP:0009825)1.74882835
90Aplasia involving bones of the upper limbs (HP:0009823)1.74882835
91Aplasia of the phalanges of the hand (HP:0009802)1.74882835
92Vascular tortuosity (HP:0004948)1.74854951
93Increased purine levels (HP:0004368)1.74481007
94Hyperuricemia (HP:0002149)1.74481007
95Abnormal eating behavior (HP:0100738)1.73517133
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73220731
97Depression (HP:0000716)1.73216030
98Hypokalemic alkalosis (HP:0001949)1.72970216
99Premature rupture of membranes (HP:0001788)1.72638287
100Shawl scrotum (HP:0000049)1.72429854
101Conjugated hyperbilirubinemia (HP:0002908)1.72133131
102Atrophic scars (HP:0001075)1.71748839
103Hyperparathyroidism (HP:0000843)1.70811554
104Focal segmental glomerulosclerosis (HP:0000097)1.70676421
105Torticollis (HP:0000473)1.70256528
106Deep palmar crease (HP:0006191)1.69813429
107Arterial tortuosity (HP:0005116)1.68905520
108Hyperglycemia (HP:0003074)1.68222175
109Papillary thyroid carcinoma (HP:0002895)1.67643333
110Hyperaldosteronism (HP:0000859)1.67356991
111Absent eyelashes (HP:0000561)1.67077550
112Absent speech (HP:0001344)1.65940008
113Mildly elevated creatine phosphokinase (HP:0008180)1.64992914
114Abnormality of vitamin metabolism (HP:0100508)1.64467826
115Exotropia (HP:0000577)1.63866680
116Hyperphosphatemia (HP:0002905)1.63424448
117Obstructive sleep apnea (HP:0002870)1.62435033
118Focal dystonia (HP:0004373)1.61345313
119Facial hemangioma (HP:0000329)1.60285617
120Prolonged partial thromboplastin time (HP:0003645)1.59925905
121Ankle clonus (HP:0011448)1.58891274
122Supranuclear gaze palsy (HP:0000605)1.58163162
123Hyperlipoproteinemia (HP:0010980)1.58102351
124Glomerulosclerosis (HP:0000096)1.57952607
125Hypophosphatemic rickets (HP:0004912)1.57831296
126Pterygium (HP:0001059)1.57665674
127Bradykinesia (HP:0002067)1.57305744
128Hyperkalemia (HP:0002153)1.56932862
129Oligodactyly (hands) (HP:0001180)1.56395186
130Abnormality of chloride homeostasis (HP:0011422)1.56200547
131Abnormality of glycine metabolism (HP:0010895)1.56128717
132Abnormality of serine family amino acid metabolism (HP:0010894)1.56128717
133Abnormality of the Achilles tendon (HP:0005109)1.55678261
134Hypolipoproteinemia (HP:0010981)1.55624845
135Proximal tubulopathy (HP:0000114)1.55145333
136Abnormality of renin-angiotensin system (HP:0000847)1.52475450
137Tetraparesis (HP:0002273)1.51757168
138Abnormality of the dental root (HP:0006486)1.51606319
139Taurodontia (HP:0000679)1.51606319
140Abnormality of permanent molar morphology (HP:0011071)1.51606319
141Postural tremor (HP:0002174)1.51171592
142Abnormality of molar (HP:0011077)1.51052074
143Abnormality of molar morphology (HP:0011070)1.51052074
144Advanced eruption of teeth (HP:0006288)1.50140078
145Abnormality of proline metabolism (HP:0010907)1.48661324
146Hydroxyprolinuria (HP:0003080)1.48661324
147Broad metatarsal (HP:0001783)1.48148007
148Thyroid carcinoma (HP:0002890)1.46631360
149Abnormality of the salivary glands (HP:0010286)1.46507585
150Insomnia (HP:0100785)1.45399098
151Absent eyebrow (HP:0002223)1.44028845
152Bundle branch block (HP:0011710)1.42037873
153Mitral stenosis (HP:0001718)1.41984003
154Overgrowth (HP:0001548)1.40748366
155Popliteal pterygium (HP:0009756)1.40454339
156Hammertoe (HP:0001765)1.39131185
157Ankyloglossia (HP:0010296)1.39045826
158Limb-girdle muscle weakness (HP:0003325)1.38343539
159Exercise-induced muscle cramps (HP:0003710)1.38162454
160Pheochromocytoma (HP:0002666)1.35946847
161Hypoalphalipoproteinemia (HP:0003233)1.34494772
162Flat acetabular roof (HP:0003180)1.34062651
163Curly hair (HP:0002212)1.33874491
164Hypoplasia of dental enamel (HP:0006297)1.32042768
165Overriding aorta (HP:0002623)1.31940004
166Nuclear cataract (HP:0100018)1.31394488
167Vertebral clefting (HP:0008428)1.29505191
168Biliary tract neoplasm (HP:0100574)1.29166433
169Spinal cord compression (HP:0002176)1.29027611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.65785284
2NTRK33.57656365
3MAP3K93.53180361
4LATS23.02011950
5MAP3K42.79672825
6KSR22.72991226
7EPHA22.57962717
8MST1R2.52019275
9LATS12.50505972
10KSR12.33993912
11MAP2K42.24974439
12MINK11.98437536
13NTRK11.91406430
14PAK61.89881962
15MAP2K71.82669549
16MAP3K131.77198581
17PRKD31.75955631
18STK38L1.74543642
19PNCK1.72974655
20ARAF1.66363090
21STK381.65693367
22RIPK41.47729153
23MAP3K21.47521818
24TYRO31.47416443
25PIK3CA1.43147912
26ERBB41.38120451
27FRK1.36601548
28AKT31.31045704
29FER1.30295798
30WNK31.30148414
31OXSR11.29877386
32WNK41.29133590
33DAPK21.24812113
34PHKG21.24329902
35PHKG11.24329902
36BCR1.23512293
37MAP3K61.23007269
38NTRK21.22133428
39PLK21.15518168
40GRK51.14787270
41STK241.12455792
42TAOK11.09282570
43PAK31.08954913
44SGK2231.06938856
45SGK4941.06938856
46RAF11.05289000
47TNIK1.03669449
48SGK21.01351113
49MAP3K121.00847888
50RET1.00770796
51PTK2B0.98727888
52CDK50.97217781
53CAMK2A0.97049921
54ERBB30.95228486
55PBK0.94071512
56EPHB20.93827705
57BMPR20.90854343
58FGFR10.88792204
59PINK10.87673632
60MST40.86560188
61PDGFRA0.86445321
62PAK40.86023825
63STK30.85981633
64MARK10.80813420
65PRKCG0.80336307
66MYLK0.80306722
67SGK30.79251847
68TTK0.78276798
69DDR20.78263360
70FGFR20.78053094
71TESK10.78038761
72DMPK0.77813522
73MAP2K10.77759190
74STK390.77325437
75CAMK1G0.77003067
76CAMK2B0.75427207
77WNK10.74877536
78NEK60.74331960
79CDK120.73148572
80BRAF0.73076693
81ICK0.72381386
82MAP3K10.71515222
83LIMK10.69930902
84NLK0.69298105
85CAMKK10.69161850
86STK110.68130476
87SCYL20.67917455
88TRIM280.67221578
89LMTK20.66347442
90SGK10.65904735
91TAOK30.65193499
92ROCK20.64791007
93DAPK10.62416996
94FGFR40.62229434
95BRSK20.61892014
96CAMK2G0.61714774
97CSNK1G20.61514221
98TSSK60.60504351
99CASK0.59297756
100INSRR0.57889012
101RIPK10.56703165
102PDPK10.55804667
103PRKD20.55539734
104FGFR30.55227194
105DYRK1A0.53819449
106SIK30.53565412
107MAPK100.52944187
108CDK180.52807553
109PRKCZ0.52511175
110CDK140.52098494
111* PTK20.51602012
112FGR0.51512446
113PRKG20.51378720
114PDGFRB0.50114975
115CSNK1G10.48708280
116PAK20.48657615
117EIF2AK30.48374541
118BRSK10.48127900
119MAP3K70.47977030
120CAMK2D0.47890666
121ERBB20.47564850
122OBSCN0.46998452
123CDK150.46959076
124MOS0.46221677
125CDK11A0.46086338
126ROCK10.45115477
127PRKAA10.45104108
128MET0.44787137
129ACVR1B0.44510314
130CSNK1E0.44387317
131PRKCE0.44300565
132UHMK10.44296464
133AKT20.44062021
134RPS6KA30.42484405
135CAMK10.39660143
136CDC42BPA0.39066709
137PRKCH0.39061265
138MARK20.38989039
139PDK10.37725157
140PRKAA20.37634868

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.90431099
2Nicotine addiction_Homo sapiens_hsa050332.54897540
3Long-term potentiation_Homo sapiens_hsa047202.11621843
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98695485
5Amphetamine addiction_Homo sapiens_hsa050311.95012106
6Synaptic vesicle cycle_Homo sapiens_hsa047211.88635557
7Arginine biosynthesis_Homo sapiens_hsa002201.86577233
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.80195038
9GABAergic synapse_Homo sapiens_hsa047271.76619895
10Glutamatergic synapse_Homo sapiens_hsa047241.75859144
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74708285
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74274926
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72252085
14Circadian entrainment_Homo sapiens_hsa047131.69544491
15Insulin secretion_Homo sapiens_hsa049111.61003876
16Vitamin B6 metabolism_Homo sapiens_hsa007501.59433265
17Dopaminergic synapse_Homo sapiens_hsa047281.52018622
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51786544
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47908676
20Bile secretion_Homo sapiens_hsa049761.46487199
21Tight junction_Homo sapiens_hsa045301.46390971
22Salivary secretion_Homo sapiens_hsa049701.45937493
23Butanoate metabolism_Homo sapiens_hsa006501.45100078
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42066263
25Arginine and proline metabolism_Homo sapiens_hsa003301.40271115
26Morphine addiction_Homo sapiens_hsa050321.35592862
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35401231
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31017654
29Taste transduction_Homo sapiens_hsa047421.30347421
30* Adherens junction_Homo sapiens_hsa045201.30180063
31Gastric acid secretion_Homo sapiens_hsa049711.27064042
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26732088
33Olfactory transduction_Homo sapiens_hsa047401.23766172
34Long-term depression_Homo sapiens_hsa047301.23752051
35Dorso-ventral axis formation_Homo sapiens_hsa043201.22011831
36GnRH signaling pathway_Homo sapiens_hsa049121.18419603
37Cocaine addiction_Homo sapiens_hsa050301.16520956
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15344601
39Protein digestion and absorption_Homo sapiens_hsa049741.13164861
40Cholinergic synapse_Homo sapiens_hsa047251.12106079
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09030890
42Retinol metabolism_Homo sapiens_hsa008301.08943414
43Caffeine metabolism_Homo sapiens_hsa002321.08489846
44Serotonergic synapse_Homo sapiens_hsa047261.08027633
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.05946594
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.05026800
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03222649
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03039748
49Renin secretion_Homo sapiens_hsa049241.02741938
50Oxytocin signaling pathway_Homo sapiens_hsa049211.02522594
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02202805
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01035033
53Melanogenesis_Homo sapiens_hsa049160.98563378
54Tryptophan metabolism_Homo sapiens_hsa003800.97991285
55Circadian rhythm_Homo sapiens_hsa047100.97808085
56Fat digestion and absorption_Homo sapiens_hsa049750.97405014
57Thyroid cancer_Homo sapiens_hsa052160.96816775
58cAMP signaling pathway_Homo sapiens_hsa040240.96432126
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94004080
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93457214
61Glioma_Homo sapiens_hsa052140.93395330
62Calcium signaling pathway_Homo sapiens_hsa040200.93100612
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92618026
64Collecting duct acid secretion_Homo sapiens_hsa049660.91883895
65Estrogen signaling pathway_Homo sapiens_hsa049150.91768822
66ErbB signaling pathway_Homo sapiens_hsa040120.90878796
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88617638
68Gap junction_Homo sapiens_hsa045400.86957060
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85955578
70ECM-receptor interaction_Homo sapiens_hsa045120.84770640
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83450104
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.82096223
73Sulfur metabolism_Homo sapiens_hsa009200.81875353
74Type II diabetes mellitus_Homo sapiens_hsa049300.81409248
75Axon guidance_Homo sapiens_hsa043600.81014634
76Thyroid hormone synthesis_Homo sapiens_hsa049180.80980401
77* Choline metabolism in cancer_Homo sapiens_hsa052310.80607750
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79839274
79Renin-angiotensin system_Homo sapiens_hsa046140.78823896
80Chemical carcinogenesis_Homo sapiens_hsa052040.78787521
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76839974
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76534427
83Glucagon signaling pathway_Homo sapiens_hsa049220.75544881
84Fatty acid degradation_Homo sapiens_hsa000710.74684978
85Dilated cardiomyopathy_Homo sapiens_hsa054140.71554356
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.71046667
87Fatty acid elongation_Homo sapiens_hsa000620.69902856
88Pancreatic secretion_Homo sapiens_hsa049720.68906174
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68085137
90Vitamin digestion and absorption_Homo sapiens_hsa049770.67181473
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67172814
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66745209
93Carbon metabolism_Homo sapiens_hsa012000.66525281
94Propanoate metabolism_Homo sapiens_hsa006400.66352880
95TGF-beta signaling pathway_Homo sapiens_hsa043500.65802789
96Oocyte meiosis_Homo sapiens_hsa041140.65175702
97PPAR signaling pathway_Homo sapiens_hsa033200.64597550
98Galactose metabolism_Homo sapiens_hsa000520.64412487
99Prion diseases_Homo sapiens_hsa050200.64104789
100Complement and coagulation cascades_Homo sapiens_hsa046100.63664471
101AMPK signaling pathway_Homo sapiens_hsa041520.63455230
102Biosynthesis of amino acids_Homo sapiens_hsa012300.62837808
103Fatty acid metabolism_Homo sapiens_hsa012120.61738903
104Focal adhesion_Homo sapiens_hsa045100.60990853
105Ovarian steroidogenesis_Homo sapiens_hsa049130.60251962
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60228744
107Folate biosynthesis_Homo sapiens_hsa007900.60083234
108Sphingolipid metabolism_Homo sapiens_hsa006000.59930183
109Insulin signaling pathway_Homo sapiens_hsa049100.58053026
110Pyruvate metabolism_Homo sapiens_hsa006200.58048027
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.57074747
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56361379
113Proteoglycans in cancer_Homo sapiens_hsa052050.56285701
114VEGF signaling pathway_Homo sapiens_hsa043700.55236509
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55175806
116Phenylalanine metabolism_Homo sapiens_hsa003600.54788801
117Mineral absorption_Homo sapiens_hsa049780.54467470
118mTOR signaling pathway_Homo sapiens_hsa041500.54434599
119Tyrosine metabolism_Homo sapiens_hsa003500.52464294
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51135305
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50123143
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49980429
123Peroxisome_Homo sapiens_hsa041460.49701737
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48043104
125Endometrial cancer_Homo sapiens_hsa052130.47232361
126Vibrio cholerae infection_Homo sapiens_hsa051100.46498795
127Glycerolipid metabolism_Homo sapiens_hsa005610.45594306
128Wnt signaling pathway_Homo sapiens_hsa043100.45381232
129beta-Alanine metabolism_Homo sapiens_hsa004100.44271013
130Bladder cancer_Homo sapiens_hsa052190.44230999
131Starch and sucrose metabolism_Homo sapiens_hsa005000.43830309
132Hippo signaling pathway_Homo sapiens_hsa043900.43811364
133Hedgehog signaling pathway_Homo sapiens_hsa043400.43681684
134Renal cell carcinoma_Homo sapiens_hsa052110.43633830
135Ras signaling pathway_Homo sapiens_hsa040140.43246041
136Rap1 signaling pathway_Homo sapiens_hsa040150.42712828
137Histidine metabolism_Homo sapiens_hsa003400.42012468

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