WBP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.60793760
2heterochromatin organization (GO:0070828)4.58390471
3nuclear pore complex assembly (GO:0051292)4.53461697
4nuclear pore organization (GO:0006999)4.46467427
5mitotic sister chromatid segregation (GO:0000070)4.42259147
6protein localization to kinetochore (GO:0034501)4.35187726
7protein localization to chromosome, centromeric region (GO:0071459)4.31589946
8establishment of integrated proviral latency (GO:0075713)4.15438136
9pre-miRNA processing (GO:0031054)4.14442196
10DNA replication-dependent nucleosome organization (GO:0034723)4.10556146
11DNA replication-dependent nucleosome assembly (GO:0006335)4.10556146
12sister chromatid segregation (GO:0000819)4.06938310
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.03611579
14mitotic nuclear envelope disassembly (GO:0007077)3.99260436
15regulation of histone H3-K27 methylation (GO:0061085)3.96148186
16fusion of sperm to egg plasma membrane (GO:0007342)3.91997530
17cilium or flagellum-dependent cell motility (GO:0001539)3.89888467
18piRNA metabolic process (GO:0034587)3.82941806
19synaptonemal complex assembly (GO:0007130)3.78669928
20ribosome assembly (GO:0042255)3.77885401
21nuclear envelope disassembly (GO:0051081)3.76419546
22membrane disassembly (GO:0030397)3.76419546
23regulation of histone H3-K9 methylation (GO:0051570)3.76336643
24sperm-egg recognition (GO:0035036)3.75481196
25synaptonemal complex organization (GO:0070193)3.72412336
26binding of sperm to zona pellucida (GO:0007339)3.71314440
27mitotic sister chromatid cohesion (GO:0007064)3.67289742
28microtubule depolymerization (GO:0007019)3.64936288
29positive regulation of chromosome segregation (GO:0051984)3.64483060
30DNA replication initiation (GO:0006270)3.61457113
31DNA topological change (GO:0006265)3.60773000
32chromatin assembly (GO:0031497)3.60075749
33chromosome condensation (GO:0030261)3.51800988
34gene silencing by RNA (GO:0031047)3.49370856
35regulation of posttranscriptional gene silencing (GO:0060147)3.48486922
36regulation of gene silencing by miRNA (GO:0060964)3.48486922
37regulation of gene silencing by RNA (GO:0060966)3.48486922
38ribosomal small subunit biogenesis (GO:0042274)3.45679399
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45100491
40mitotic chromosome condensation (GO:0007076)3.44988279
41folic acid-containing compound biosynthetic process (GO:0009396)3.44910271
42sperm motility (GO:0030317)3.43202081
43motile cilium assembly (GO:0044458)3.42618227
44cell-cell recognition (GO:0009988)3.40586272
45male meiosis (GO:0007140)3.38612127
46DNA strand elongation involved in DNA replication (GO:0006271)3.36554995
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.36245827
48pore complex assembly (GO:0046931)3.35341936
49regulation of RNA export from nucleus (GO:0046831)3.33491218
50mRNA stabilization (GO:0048255)3.33020566
51RNA stabilization (GO:0043489)3.33020566
52telomere maintenance via recombination (GO:0000722)3.32521815
53DNA replication checkpoint (GO:0000076)3.30241938
54spermatid development (GO:0007286)3.27300372
55regulation of translational fidelity (GO:0006450)3.26892824
56peptidyl-arginine omega-N-methylation (GO:0035247)3.26363445
57DNA duplex unwinding (GO:0032508)3.25697835
58mRNA splicing, via spliceosome (GO:0000398)3.25077395
59RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.25077395
60DNA geometric change (GO:0032392)3.23972225
61negative regulation of histone methylation (GO:0031061)3.23836337
62acrosome assembly (GO:0001675)3.22668373
63gene silencing (GO:0016458)3.21078332
64RNA splicing, via transesterification reactions (GO:0000375)3.21035649
65protein localization to chromosome (GO:0034502)3.20993997
66DNA packaging (GO:0006323)3.20304638
67protein-DNA complex disassembly (GO:0032986)3.18773942
68nucleosome disassembly (GO:0006337)3.18773942
69axonemal dynein complex assembly (GO:0070286)3.17756665
70IMP biosynthetic process (GO:0006188)3.16849617
71DNA strand elongation (GO:0022616)3.16304970
72regulation of translational termination (GO:0006449)3.14975659
73ribosome biogenesis (GO:0042254)3.13447945
74mitotic recombination (GO:0006312)3.13107578
75mitotic metaphase plate congression (GO:0007080)3.12889055
76maturation of SSU-rRNA (GO:0030490)3.12740492
77dosage compensation (GO:0007549)3.12554860
78formation of translation preinitiation complex (GO:0001731)3.11978382
79ribonucleoprotein complex biogenesis (GO:0022613)3.10532610
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09097456
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09097456
82positive regulation of mitotic sister chromatid separation (GO:1901970)3.09097456
83regulation of chromosome segregation (GO:0051983)3.04909943
84IMP metabolic process (GO:0046040)3.04691567
85DNA conformation change (GO:0071103)3.04554638
86cellular protein complex localization (GO:0034629)3.04319709
87translesion synthesis (GO:0019985)3.03867110
88nuclear envelope organization (GO:0006998)3.01832925
89purine nucleobase biosynthetic process (GO:0009113)3.01421895
90negative regulation of mRNA processing (GO:0050686)3.00198177
91regulation of centrosome cycle (GO:0046605)2.99977277
92establishment of viral latency (GO:0019043)2.99975929
93regulation of cilium movement (GO:0003352)2.99562619
94negative regulation of mRNA metabolic process (GO:1903312)2.99015829
95ribosomal large subunit biogenesis (GO:0042273)2.99004972
96DNA synthesis involved in DNA repair (GO:0000731)2.98556336
97chromosome segregation (GO:0007059)2.98089783
98spliceosomal tri-snRNP complex assembly (GO:0000244)2.98085552
99mRNA transport (GO:0051028)2.97483930
100intracellular estrogen receptor signaling pathway (GO:0030520)2.95674222
101regulation of mitotic spindle organization (GO:0060236)2.95522882
102chromatin silencing (GO:0006342)2.95126248
103chromosome organization involved in meiosis (GO:0070192)2.94311723
104chaperone-mediated protein complex assembly (GO:0051131)2.93951307
105histone H4-K12 acetylation (GO:0043983)2.93947988
106kinetochore organization (GO:0051383)2.92872502
107regulation of centriole replication (GO:0046599)2.92555578
108negative regulation of RNA splicing (GO:0033119)2.92098802
109DNA ligation (GO:0006266)2.91793721
110establishment of chromosome localization (GO:0051303)2.91413724
111attachment of spindle microtubules to kinetochore (GO:0008608)2.91133260
112somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90702897
113somatic hypermutation of immunoglobulin genes (GO:0016446)2.90702897
114regulation of nucleobase-containing compound transport (GO:0032239)2.90221235
115regulation of sister chromatid cohesion (GO:0007063)2.89591213
116non-recombinational repair (GO:0000726)2.89401080
117double-strand break repair via nonhomologous end joining (GO:0006303)2.89401080
1183-UTR-mediated mRNA stabilization (GO:0070935)2.89214191
119meiotic nuclear division (GO:0007126)2.88876411
120regulation of spindle organization (GO:0090224)2.88567186
121nucleobase biosynthetic process (GO:0046112)2.88469375
122ribosomal small subunit assembly (GO:0000028)2.88367618
123nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88346680
124histone arginine methylation (GO:0034969)2.87210988
125peptidyl-arginine N-methylation (GO:0035246)2.86687735
126peptidyl-arginine methylation (GO:0018216)2.86687735
127metaphase plate congression (GO:0051310)2.84337322
128rRNA transcription (GO:0009303)2.83827147
129ATP-dependent chromatin remodeling (GO:0043044)2.83821272
130protein complex localization (GO:0031503)2.83758770
131protein export from nucleus (GO:0006611)2.83419175
132multicellular organism reproduction (GO:0032504)2.83014306
133positive regulation of DNA-dependent DNA replication (GO:2000105)2.82519317
134plasma membrane fusion (GO:0045026)2.82318268
135telomere maintenance via telomere lengthening (GO:0010833)2.81564208
136telomere maintenance via semi-conservative replication (GO:0032201)2.81023611
137chromatin assembly or disassembly (GO:0006333)2.80420731
138RNA export from nucleus (GO:0006405)2.80209903
139epithelial cilium movement (GO:0003351)2.79111272
140mRNA export from nucleus (GO:0006406)2.78412330
141regulation of DNA endoreduplication (GO:0032875)2.78297078
142V(D)J recombination (GO:0033151)2.77815954
143regulation of meiosis I (GO:0060631)2.77764854
144translational initiation (GO:0006413)2.77067206
145regulation of mRNA stability (GO:0043488)2.76461277
146termination of RNA polymerase II transcription (GO:0006369)2.76367389
147DNA replication-independent nucleosome organization (GO:0034724)2.75904731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.18095730
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.47666970
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.16948406
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50534004
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20199914
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.17282456
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02096181
8MYC_22102868_ChIP-Seq_BL_Human2.85485173
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75092955
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.60501049
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49735604
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14707110
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08471622
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.01006368
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00097693
16XRN2_22483619_ChIP-Seq_HELA_Human1.99505270
17AR_21909140_ChIP-Seq_LNCAP_Human1.92094760
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.91345736
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81690360
20* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.77729028
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75182468
22* GABP_17652178_ChIP-ChIP_JURKAT_Human1.75043337
23VDR_21846776_ChIP-Seq_THP-1_Human1.74177204
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64592013
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64592013
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64592013
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64497947
28CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63578418
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63261664
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61917549
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59418714
32CIITA_25753668_ChIP-Seq_RAJI_Human1.59294027
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58716659
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54773641
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.54237033
36KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53792473
37* EST1_17652178_ChIP-ChIP_JURKAT_Human1.50880918
38KDM5A_27292631_Chip-Seq_BREAST_Human1.50429254
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49601779
40* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49502589
41TCF7_22412390_ChIP-Seq_EML_Mouse1.47576650
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44775467
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42480214
44* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41360174
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39478158
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37915777
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37078265
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36465461
49TTF2_22483619_ChIP-Seq_HELA_Human1.35665790
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34914499
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34417927
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34071849
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33063565
54KDM2B_26808549_Chip-Seq_DND41_Human1.32950567
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32286560
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32126257
57NANOG_21062744_ChIP-ChIP_HESCs_Human1.30634364
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30133691
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28961729
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27525479
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25908103
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25320507
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25172541
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24722936
65GABP_19822575_ChIP-Seq_HepG2_Human1.24253653
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23628468
67FOXP3_21729870_ChIP-Seq_TREG_Human1.22984382
68* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22638281
69* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22507936
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21139317
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19838669
72* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16379490
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15571904
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15455110
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13450820
76UTX_26944678_Chip-Seq_JUKART_Human1.13275818
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11897510
78VDR_23849224_ChIP-Seq_CD4+_Human1.11651110
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.11500884
80ELK1_19687146_ChIP-ChIP_HELA_Human1.11451982
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10645307
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.09797180
83CHD1_26751641_Chip-Seq_LNCaP_Human1.09042316
84* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07929181
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07179498
86DCP1A_22483619_ChIP-Seq_HELA_Human1.07018250
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04748185
88* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01492897
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01291386
90* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00969364
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.00959024
92MAF_26560356_Chip-Seq_TH1_Human1.00513191
93PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00403314
94ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99821157
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99362142
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98013775
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97988343
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96588689
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94444644
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93884820
101E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92269541
102GATA1_26923725_Chip-Seq_HPCs_Mouse0.92052317
103NCOR1_26117541_ChIP-Seq_K562_Human0.91403136
104* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91142307
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90577780
106TFEB_21752829_ChIP-Seq_HELA_Human0.90544025
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90473757
108MAF_26560356_Chip-Seq_TH2_Human0.89466346
109* FOXP1_21924763_ChIP-Seq_HESCs_Human0.88088692
110ZNF263_19887448_ChIP-Seq_K562_Human0.88057457
111POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87971469
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.87020993
113TP53_22127205_ChIP-Seq_IMR90_Human0.86758514
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86616387
115CLOCK_20551151_ChIP-Seq_293T_Human0.86534699
116NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85458415
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84879952
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84864642
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83734722
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83440740
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79933213
122SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79428005
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76943367
124NOTCH1_21737748_ChIP-Seq_TLL_Human0.76886263
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75524154
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.74849530
127HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.74842320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.30205186
2MP0003111_abnormal_nucleus_morphology3.98396927
3MP0010094_abnormal_chromosome_stability3.69516146
4MP0008057_abnormal_DNA_replication3.65023334
5MP0004957_abnormal_blastocyst_morpholog3.57727810
6MP0003693_abnormal_embryo_hatching3.53842571
7MP0008877_abnormal_DNA_methylation3.46080234
8MP0003077_abnormal_cell_cycle3.17133891
9MP0001730_embryonic_growth_arrest2.63809123
10MP0003123_paternal_imprinting2.58743701
11MP0002653_abnormal_ependyma_morphology2.52051312
12MP0005076_abnormal_cell_differentiation2.42754555
13MP0001929_abnormal_gametogenesis2.28826360
14MP0010352_gastrointestinal_tract_polyps2.25255903
15MP0000350_abnormal_cell_proliferation2.23806879
16MP0003698_abnormal_male_reproductive2.14416595
17MP0008932_abnormal_embryonic_tissue2.05030476
18MP0010307_abnormal_tumor_latency2.01848284
19MP0008058_abnormal_DNA_repair2.01123358
20MP0005380_embryogenesis_phenotype2.00146271
21MP0001672_abnormal_embryogenesis/_devel2.00146271
22MP0008007_abnormal_cellular_replicative1.99057473
23MP0001697_abnormal_embryo_size1.98953920
24MP0002084_abnormal_developmental_patter1.97223605
25MP0002877_abnormal_melanocyte_morpholog1.96233472
26MP0002085_abnormal_embryonic_tissue1.95341950
27MP0002210_abnormal_sex_determination1.94624206
28MP0004197_abnormal_fetal_growth/weight/1.86792212
29MP0002009_preneoplasia1.85294556
30MP0003984_embryonic_growth_retardation1.81908746
31MP0002088_abnormal_embryonic_growth/wei1.77836503
32MP0001145_abnormal_male_reproductive1.75512528
33MP0003121_genomic_imprinting1.72866959
34MP0002080_prenatal_lethality1.70343872
35MP0009278_abnormal_bone_marrow1.67696284
36MP0002086_abnormal_extraembryonic_tissu1.66840901
37MP0005623_abnormal_meninges_morphology1.59708858
38MP0000537_abnormal_urethra_morphology1.56469160
39MP0004233_abnormal_muscle_weight1.45843893
40MP0001849_ear_inflammation1.44347590
41MP0002396_abnormal_hematopoietic_system1.44287218
42MP0003119_abnormal_digestive_system1.42602028
43MP0003718_maternal_effect1.42087516
44MP0000653_abnormal_sex_gland1.41172895
45MP0004133_heterotaxia1.35597948
46MP0002161_abnormal_fertility/fecundity1.35304861
47MP0000313_abnormal_cell_death1.31410455
48MP0003786_premature_aging1.29094313
49MP0004808_abnormal_hematopoietic_stem1.25758012
50MP0003890_abnormal_embryonic-extraembry1.24093299
51MP0000490_abnormal_crypts_of1.20852750
52MP0000703_abnormal_thymus_morphology1.19238058
53MP0003567_abnormal_fetal_cardiomyocyte1.17795529
54MP0002019_abnormal_tumor_incidence1.15777070
55MP0010030_abnormal_orbit_morphology1.10557597
56MP0005377_hearing/vestibular/ear_phenot1.09885273
57MP0003878_abnormal_ear_physiology1.09885273
58MP0005397_hematopoietic_system_phenotyp1.09124435
59MP0001545_abnormal_hematopoietic_system1.09124435
60MP0002163_abnormal_gland_morphology1.09117322
61MP0006035_abnormal_mitochondrial_morpho1.07938906
62MP0009672_abnormal_birth_weight1.07077602
63MP0003861_abnormal_nervous_system1.06096629
64MP0010234_abnormal_vibrissa_follicle1.05866220
65MP0003787_abnormal_imprinting1.04744342
66MP0009703_decreased_birth_body1.03345734
67MP0001293_anophthalmia1.01509688
68MP0001346_abnormal_lacrimal_gland1.01217157
69MP0009333_abnormal_splenocyte_physiolog0.98638357
70MP0002160_abnormal_reproductive_system0.98612073
71MP0009053_abnormal_anal_canal0.98497691
72MP0003705_abnormal_hypodermis_morpholog0.98443794
73MP0003115_abnormal_respiratory_system0.96545185
74MP0001727_abnormal_embryo_implantation0.96532540
75MP0003122_maternal_imprinting0.94995064
76MP0003221_abnormal_cardiomyocyte_apopto0.94804546
77MP0000733_abnormal_muscle_development0.94387147
78MP0003943_abnormal_hepatobiliary_system0.92456638
79MP0001348_abnormal_lacrimal_gland0.91274157
80MP0008770_decreased_survivor_rate0.89373183
81MP0002796_impaired_skin_barrier0.89355148
82MP0002925_abnormal_cardiovascular_devel0.88583759
83MP0002398_abnormal_bone_marrow0.88415393
84MP0005501_abnormal_skin_physiology0.86833709
85MP0005451_abnormal_body_composition0.86371782
86MP0009697_abnormal_copulation0.85220285
87MP0004264_abnormal_extraembryonic_tissu0.85141112
88MP0003656_abnormal_erythrocyte_physiolo0.84882961
89MP0001853_heart_inflammation0.83820887
90MP0006036_abnormal_mitochondrial_physio0.81213243
91MP0002166_altered_tumor_susceptibility0.81028272
92MP0000358_abnormal_cell_content/0.79710633
93MP0008995_early_reproductive_senescence0.79457884
94MP0003303_peritoneal_inflammation0.79041049
95MP0002722_abnormal_immune_system0.77366801
96MP0003385_abnormal_body_wall0.75822653
97MP0001915_intracranial_hemorrhage0.75550220
98MP0010630_abnormal_cardiac_muscle0.74325488
99MP0004185_abnormal_adipocyte_glucose0.74183653
100MP0002111_abnormal_tail_morphology0.73235647
101MP0001784_abnormal_fluid_regulation0.73157769
102MP0003935_abnormal_craniofacial_develop0.72063312
103MP0000428_abnormal_craniofacial_morphol0.72044116
104MP0005384_cellular_phenotype0.71300720
105MP0002006_tumorigenesis0.69803620
106MP0003937_abnormal_limbs/digits/tail_de0.69532436
107MP0004381_abnormal_hair_follicle0.69441357
108MP0000003_abnormal_adipose_tissue0.68869101
109MP0000432_abnormal_head_morphology0.68758491
110MP0002089_abnormal_postnatal_growth/wei0.68571593
111MP0002429_abnormal_blood_cell0.68490955
112MP0000266_abnormal_heart_morphology0.67898212
113MP0005257_abnormal_intraocular_pressure0.66528648
114MP0005621_abnormal_cell_physiology0.65954194
115MP0003315_abnormal_perineum_morphology0.65701562
116MP0003699_abnormal_female_reproductive0.65292585
117MP0002092_abnormal_eye_morphology0.65082587
118MP0000689_abnormal_spleen_morphology0.65078568
119MP0002970_abnormal_white_adipose0.64665807
120MP0000678_abnormal_parathyroid_gland0.63668680
121MP0002697_abnormal_eye_size0.63063510
122MP0002114_abnormal_axial_skeleton0.62968723
123MP0002282_abnormal_trachea_morphology0.62554471
124MP0001286_abnormal_eye_development0.62133380
125MP0003763_abnormal_thymus_physiology0.60830518
126MP0003566_abnormal_cell_adhesion0.60211499
127MP0008961_abnormal_basal_metabolism0.60130371
128MP0005670_abnormal_white_adipose0.58833181
129MP0005666_abnormal_adipose_tissue0.56934844
130MP0005075_abnormal_melanosome_morpholog0.56837804
131MP0001881_abnormal_mammary_gland0.55549260

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.90403911
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.60072710
3Absent/shortened dynein arms (HP:0200106)4.60072710
4Ependymoma (HP:0002888)3.88219962
5Progressive muscle weakness (HP:0003323)3.67641455
6Nasal polyposis (HP:0100582)3.40394567
7Microvesicular hepatic steatosis (HP:0001414)3.26432580
8Selective tooth agenesis (HP:0001592)3.23751214
9Abnormal respiratory epithelium morphology (HP:0012253)3.21976430
10Abnormal respiratory motile cilium morphology (HP:0005938)3.21976430
11Medulloblastoma (HP:0002885)3.10755682
12Septate vagina (HP:0001153)3.08058463
13Abnormality of the lower motor neuron (HP:0002366)3.04992199
14Abnormal respiratory motile cilium physiology (HP:0012261)3.01948403
15Progressive external ophthalmoplegia (HP:0000590)2.99065018
16Abnormality of cells of the erythroid lineage (HP:0012130)2.90626741
17Rhinitis (HP:0012384)2.89248101
18Abnormality of the astrocytes (HP:0100707)2.86690027
19Astrocytoma (HP:0009592)2.86690027
20Multiple enchondromatosis (HP:0005701)2.86386883
21Reticulocytopenia (HP:0001896)2.85474884
22Abnormality of glycolysis (HP:0004366)2.84820145
23Urethral obstruction (HP:0000796)2.84529772
24Supernumerary spleens (HP:0009799)2.76390668
25Increased nuchal translucency (HP:0010880)2.73390239
26Impulsivity (HP:0100710)2.70138282
27Infertility (HP:0000789)2.67943985
28Abnormality of the nasal mucosa (HP:0000433)2.66302164
29Basal cell carcinoma (HP:0002671)2.59292658
30Rib fusion (HP:0000902)2.57890152
31Amyotrophic lateral sclerosis (HP:0007354)2.53697529
32Abnormal number of erythroid precursors (HP:0012131)2.50933230
33Abnormal gallbladder physiology (HP:0012438)2.49083786
34Cholecystitis (HP:0001082)2.49083786
35Male infertility (HP:0003251)2.43882170
36Abnormality of the labia minora (HP:0012880)2.43185404
37Neoplasm of striated muscle (HP:0009728)2.41952106
38Volvulus (HP:0002580)2.40563883
39Rhabdomyosarcoma (HP:0002859)2.39472850
40Chronic bronchitis (HP:0004469)2.39409542
41Proximal placement of thumb (HP:0009623)2.39142819
42Trismus (HP:0000211)2.36636052
43Ectopic kidney (HP:0000086)2.35409409
44Degeneration of anterior horn cells (HP:0002398)2.32690360
45Abnormality of the anterior horn cell (HP:0006802)2.32690360
46Increased serum pyruvate (HP:0003542)2.31083372
47Neoplasm of the oral cavity (HP:0100649)2.28594780
48Heterotopia (HP:0002282)2.27974837
49Secondary amenorrhea (HP:0000869)2.27665169
50Cortical dysplasia (HP:0002539)2.26649543
51Aplasia/hypoplasia of the humerus (HP:0006507)2.26276045
52Patellar aplasia (HP:0006443)2.25483050
53Deviation of the thumb (HP:0009603)2.24126953
54Abnormal ciliary motility (HP:0012262)2.23837989
55Abnormality of chromosome segregation (HP:0002916)2.23355565
56Short humerus (HP:0005792)2.22995004
57Premature ovarian failure (HP:0008209)2.21981194
58High pitched voice (HP:0001620)2.21724821
59Missing ribs (HP:0000921)2.21608807
60Hyperacusis (HP:0010780)2.20788378
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20301612
62Supernumerary ribs (HP:0005815)2.19486900
63Unilateral renal agenesis (HP:0000122)2.18777789
64Absent radius (HP:0003974)2.18685851
65Short 4th metacarpal (HP:0010044)2.18108355
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.18108355
67Absent thumb (HP:0009777)2.17913095
68Macrocytic anemia (HP:0001972)2.17347091
69Renal duplication (HP:0000075)2.15491514
70Agnosia (HP:0010524)2.14730606
71Squamous cell carcinoma (HP:0002860)2.12176715
72Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12090778
73Glioma (HP:0009733)2.11477708
74Nephroblastoma (Wilms tumor) (HP:0002667)2.09744101
75Chromsome breakage (HP:0040012)2.09627824
76Facial cleft (HP:0002006)2.09451425
77Aplasia/Hypoplasia of the patella (HP:0006498)2.08669145
78Facial hemangioma (HP:0000329)2.08516522
79Deep philtrum (HP:0002002)2.07894411
80Abnormality of the ileum (HP:0001549)2.06907960
81Meckel diverticulum (HP:0002245)2.05734062
82Absent forearm bone (HP:0003953)2.04611205
83Aplasia involving forearm bones (HP:0009822)2.04611205
84Ragged-red muscle fibers (HP:0003200)2.04585360
85Cafe-au-lait spot (HP:0000957)2.03538490
86Supernumerary bones of the axial skeleton (HP:0009144)2.03402573
87Upper limb muscle weakness (HP:0003484)2.03128203
88Glossoptosis (HP:0000162)2.02542360
89Obsessive-compulsive behavior (HP:0000722)2.01619325
90Atrophy/Degeneration involving motor neurons (HP:0007373)2.01554735
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01384185
92Abnormality of chromosome stability (HP:0003220)1.98640224
93Carpal bone hypoplasia (HP:0001498)1.97208509
94Abdominal situs inversus (HP:0003363)1.97033462
95Abnormality of abdominal situs (HP:0011620)1.97033462
96High anterior hairline (HP:0009890)1.93651464
97Small intestinal stenosis (HP:0012848)1.93645073
98Duodenal stenosis (HP:0100867)1.93645073
99Overlapping toe (HP:0001845)1.91923219
100Prominent nose (HP:0000448)1.91652000
101Embryonal renal neoplasm (HP:0011794)1.90748671
102Breast hypoplasia (HP:0003187)1.90246816
103Choanal atresia (HP:0000453)1.89981482
104Abnormality of cochlea (HP:0000375)1.89499986
105Long palpebral fissure (HP:0000637)1.89022361
106Aplasia/Hypoplasia of the uvula (HP:0010293)1.88907693
107Bronchitis (HP:0012387)1.88796260
108Colon cancer (HP:0003003)1.87668140
109Atresia of the external auditory canal (HP:0000413)1.87497946
110Bronchiectasis (HP:0002110)1.87462400
111Trigonocephaly (HP:0000243)1.87225486
112Dysmetric saccades (HP:0000641)1.87107048
113Pseudobulbar signs (HP:0002200)1.87081079
114Abnormality of the salivary glands (HP:0010286)1.86558529
115Horseshoe kidney (HP:0000085)1.86070844
116Esophageal atresia (HP:0002032)1.84290398
117Abnormal number of incisors (HP:0011064)1.84253702
118Deep palmar crease (HP:0006191)1.84191511
119Broad distal phalanx of finger (HP:0009836)1.83839033
120Asplenia (HP:0001746)1.83183851
121Short middle phalanx of the 5th finger (HP:0004220)1.83056253
122Dysphonia (HP:0001618)1.82510573
123Abnormal lung lobation (HP:0002101)1.82488302
124Broad palm (HP:0001169)1.81264914
125Aplasia/Hypoplasia of the spleen (HP:0010451)1.81110837
126Insomnia (HP:0100785)1.80790208
127Abnormality of the carotid arteries (HP:0005344)1.80756053
128Insidious onset (HP:0003587)1.80440028
129Termporal pattern (HP:0011008)1.80440028
130Acute myeloid leukemia (HP:0004808)1.79719685
131Neuroblastic tumors (HP:0004376)1.79434208
132Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.79434208
133Neuroblastoma (HP:0003006)1.79434208
134Primitive neuroectodermal tumor (HP:0030065)1.79434208
135Abnormality of the preputium (HP:0100587)1.78809479
136Abnormality of the fingertips (HP:0001211)1.77642214
137Embryonal neoplasm (HP:0002898)1.77631879
138Hypergonadotropic hypogonadism (HP:0000815)1.76187405
139Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75851989
140Gout (HP:0001997)1.75576743
141Myelodysplasia (HP:0002863)1.74416161
142Abnormality of reticulocytes (HP:0004312)1.74077535
143Truncus arteriosus (HP:0001660)1.73217281
144Pelvic girdle muscle weakness (HP:0003749)1.72630536
145Acute lymphatic leukemia (HP:0006721)1.71719275
146Cleft eyelid (HP:0000625)1.71643524
147Birth length less than 3rd percentile (HP:0003561)1.71143792
148Short ribs (HP:0000773)1.70584621
149Centrally nucleated skeletal muscle fibers (HP:0003687)1.69805974
150Skin tags (HP:0010609)1.69628210
151Abnormal umbilical cord blood vessels (HP:0011403)1.69233967
152Single umbilical artery (HP:0001195)1.69233967
153Abnormality of the fetal cardiovascular system (HP:0010948)1.69233967
154Neoplasm of the adrenal cortex (HP:0100641)1.68719935
155Overriding aorta (HP:0002623)1.68638130
156Long eyelashes (HP:0000527)1.68563749
157Shoulder girdle muscle weakness (HP:0003547)1.68473405
158Neoplasm of the pancreas (HP:0002894)1.68353594
159Annular pancreas (HP:0001734)1.68243415
160Personality changes (HP:0000751)1.67604225
161Pallor (HP:0000980)1.67418472
162Elfin facies (HP:0004428)1.64210289
163Impaired proprioception (HP:0010831)1.64150118
164Orthostatic hypotension (HP:0001278)1.61270331
165Preauricular skin tag (HP:0000384)1.58537850
166Progressive hearing impairment (HP:0001730)1.58277990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.22535378
2CDC73.92190878
3SMG13.68513429
4ICK3.50111233
5NEK23.32652492
6EEF2K3.30092661
7MAP3K103.02668821
8BUB12.87848743
9VRK22.75423623
10TTK2.41669129
11PNCK2.40895101
12WEE12.36510807
13PDK42.34563257
14PDK32.34563257
15TESK12.20941678
16TAF12.11197851
17PRKD32.07928443
18NME22.05145510
19PRPF4B2.04606006
20STK101.76615524
21ALK1.68285829
22MAP3K91.63738224
23PASK1.59002949
24MAP3K81.55388024
25TESK21.54704426
26CDK41.52373310
27CDK71.51444244
28NEK11.49377960
29KSR21.46882913
30SIK31.46227143
31TYRO31.42904090
32RPS6KB21.42277384
33CHEK11.41663127
34TSSK61.38175365
35PLK11.36728891
36PKN21.36636570
37TRIB31.34385277
38ATR1.30232288
39BRD41.28189637
40CHEK21.26400246
41MAP4K11.21142466
42EIF2AK31.20891341
43GRK61.17649261
44MTOR1.17592027
45PBK1.13419155
46LATS21.09551017
47PAK41.07993605
48MAP3K141.00986754
49CDK80.97048189
50BMX0.96733879
51PDK20.96509751
52EIF2AK20.96267469
53AURKA0.95535958
54VRK10.94916543
55NME10.94504112
56MET0.94161707
57CDK20.94140441
58STK30.94039602
59ATM0.93710167
60MST1R0.91062280
61AURKB0.89024403
62MST40.85407430
63PAK10.84778127
64DYRK30.84139016
65PTK2B0.83663283
66DAPK10.80588278
67EPHA20.80487855
68SIK10.79916658
69CDK60.78130065
70TRIM280.77547506
71CDK190.76802186
72IRAK30.76497362
73MKNK10.75744203
74CLK10.75658054
75FGFR40.75533490
76PLK30.75173210
77MAP3K130.74713738
78TAOK10.72225950
79PIM10.66715158
80CDK10.66084653
81MAP2K20.65589761
82SRPK10.64514546
83MELK0.63759070
84STK160.63523436
85BRSK10.63202744
86PAK20.61274915
87STK40.59659248
88ACVR1B0.59365242
89IRAK20.59289840
90SIK20.58753634
91BRAF0.57437806
92CAMK1D0.55856962
93CSNK1E0.55433555
94UHMK10.54923916
95MKNK20.53172557
96ARAF0.52513811
97DMPK0.52465432
98BRSK20.51558314
99SCYL20.51337833
100MAP3K110.50861333
101TGFBR10.49014207
102PTK60.48558987
103CDK11A0.47963221
104CDK90.47614398
105WNK10.47561920
106MAP3K20.47417030
107PAK60.47401796
108EIF2AK10.46876909
109LRRK20.45520161
110RPS6KA10.44909503
111CSNK1D0.44899349
112FGR0.44700152
113CDK140.44299711
114CDK150.44156050
115CSNK2A20.43056624
116CDK30.39270600
117PRKDC0.38716579
118MAPK140.38315028
119CDK180.37975290
120RPS6KA40.37826630
121GSK3B0.36943984
122MAPK110.34792362
123PLK40.33502065
124CSNK1G10.33331526
125DYRK1B0.33046477
126TAOK20.33020426
127AKT20.32921996
128MAPK100.32305414
129STK380.32073228
130MAPK10.30773403
131CAMK1G0.29422125
132RAF10.29186975

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.93038313
2Mismatch repair_Homo sapiens_hsa034303.46229084
3RNA transport_Homo sapiens_hsa030133.36954983
4* Spliceosome_Homo sapiens_hsa030403.20769156
5mRNA surveillance pathway_Homo sapiens_hsa030152.78766563
6Cell cycle_Homo sapiens_hsa041102.75733391
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65908499
8Base excision repair_Homo sapiens_hsa034102.60010972
9Homologous recombination_Homo sapiens_hsa034402.18586511
10Nucleotide excision repair_Homo sapiens_hsa034202.07420683
11Fanconi anemia pathway_Homo sapiens_hsa034602.06181525
12Oocyte meiosis_Homo sapiens_hsa041141.97786904
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92707346
14Basal transcription factors_Homo sapiens_hsa030221.75132105
15RNA degradation_Homo sapiens_hsa030181.67967681
16One carbon pool by folate_Homo sapiens_hsa006701.60066627
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56540054
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46721841
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45300313
20p53 signaling pathway_Homo sapiens_hsa041151.32422687
21RNA polymerase_Homo sapiens_hsa030201.31282707
22Dorso-ventral axis formation_Homo sapiens_hsa043201.31215692
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30376782
24Ribosome_Homo sapiens_hsa030101.29649000
25Non-homologous end-joining_Homo sapiens_hsa034501.20346532
26Thyroid cancer_Homo sapiens_hsa052161.19926816
27Viral carcinogenesis_Homo sapiens_hsa052031.14381654
28Carbon metabolism_Homo sapiens_hsa012001.14072514
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.11841991
30MicroRNAs in cancer_Homo sapiens_hsa052061.09996688
31Epstein-Barr virus infection_Homo sapiens_hsa051691.09942202
32Pyrimidine metabolism_Homo sapiens_hsa002401.09581760
33mTOR signaling pathway_Homo sapiens_hsa041501.08623972
34HTLV-I infection_Homo sapiens_hsa051661.08123713
35Chronic myeloid leukemia_Homo sapiens_hsa052201.06313574
36VEGF signaling pathway_Homo sapiens_hsa043701.04512004
37Antigen processing and presentation_Homo sapiens_hsa046121.04176465
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.03250287
39Colorectal cancer_Homo sapiens_hsa052101.02188406
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00388041
41Basal cell carcinoma_Homo sapiens_hsa052170.99487824
42Hedgehog signaling pathway_Homo sapiens_hsa043400.98967123
43Hippo signaling pathway_Homo sapiens_hsa043900.98196831
44B cell receptor signaling pathway_Homo sapiens_hsa046620.97181263
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95349268
46Proteasome_Homo sapiens_hsa030500.94687217
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93910025
48Bladder cancer_Homo sapiens_hsa052190.92014953
49Non-small cell lung cancer_Homo sapiens_hsa052230.92000929
50Notch signaling pathway_Homo sapiens_hsa043300.90208045
51Acute myeloid leukemia_Homo sapiens_hsa052210.89189895
52Shigellosis_Homo sapiens_hsa051310.86687421
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85727313
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85041652
55Renal cell carcinoma_Homo sapiens_hsa052110.84448609
56Adherens junction_Homo sapiens_hsa045200.80857745
57T cell receptor signaling pathway_Homo sapiens_hsa046600.80232567
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79619830
59Protein export_Homo sapiens_hsa030600.75995635
60Circadian rhythm_Homo sapiens_hsa047100.74397974
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73168066
62Wnt signaling pathway_Homo sapiens_hsa043100.72668158
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72518373
64Herpes simplex infection_Homo sapiens_hsa051680.72260776
65Estrogen signaling pathway_Homo sapiens_hsa049150.72166418
66Long-term potentiation_Homo sapiens_hsa047200.71152909
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70181995
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68319088
69Pentose phosphate pathway_Homo sapiens_hsa000300.66770526
70Endometrial cancer_Homo sapiens_hsa052130.66700041
71Folate biosynthesis_Homo sapiens_hsa007900.66468603
72Glucagon signaling pathway_Homo sapiens_hsa049220.64888832
73TGF-beta signaling pathway_Homo sapiens_hsa043500.63971688
74Glioma_Homo sapiens_hsa052140.63647083
75HIF-1 signaling pathway_Homo sapiens_hsa040660.63529389
76Small cell lung cancer_Homo sapiens_hsa052220.63114711
77Prostate cancer_Homo sapiens_hsa052150.62499507
78Tight junction_Homo sapiens_hsa045300.62365927
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.62000773
80Viral myocarditis_Homo sapiens_hsa054160.60999876
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60757590
82Proteoglycans in cancer_Homo sapiens_hsa052050.58130468
83Pathways in cancer_Homo sapiens_hsa052000.56741196
84Biosynthesis of amino acids_Homo sapiens_hsa012300.56537764
85Measles_Homo sapiens_hsa051620.55325678
86Pyruvate metabolism_Homo sapiens_hsa006200.55180449
87Vitamin B6 metabolism_Homo sapiens_hsa007500.54558594
88N-Glycan biosynthesis_Homo sapiens_hsa005100.54375768
89Purine metabolism_Homo sapiens_hsa002300.51947822
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51725569
91Selenocompound metabolism_Homo sapiens_hsa004500.51632177
92Endocytosis_Homo sapiens_hsa041440.51273659
93Sulfur relay system_Homo sapiens_hsa041220.51059418
94Lysine degradation_Homo sapiens_hsa003100.50910543
95Hepatitis B_Homo sapiens_hsa051610.50590188
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48744525
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47395307
98Pancreatic cancer_Homo sapiens_hsa052120.46974359
99MAPK signaling pathway_Homo sapiens_hsa040100.43409898
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43183455
101ErbB signaling pathway_Homo sapiens_hsa040120.43001009
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42370653
103Legionellosis_Homo sapiens_hsa051340.41704757
104AMPK signaling pathway_Homo sapiens_hsa041520.41669334
105Apoptosis_Homo sapiens_hsa042100.40664477
106Fructose and mannose metabolism_Homo sapiens_hsa000510.40599120
107Primary immunodeficiency_Homo sapiens_hsa053400.39184264
108Salmonella infection_Homo sapiens_hsa051320.38535586
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.36965123
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36804269
111Gap junction_Homo sapiens_hsa045400.36721005
112Huntingtons disease_Homo sapiens_hsa050160.35281499
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.34541488
114Choline metabolism in cancer_Homo sapiens_hsa052310.32495063
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.31865888
116Insulin signaling pathway_Homo sapiens_hsa049100.31727444
117Influenza A_Homo sapiens_hsa051640.31045979
118Inositol phosphate metabolism_Homo sapiens_hsa005620.30736715
119Melanogenesis_Homo sapiens_hsa049160.30386282
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27096354
121Fatty acid elongation_Homo sapiens_hsa000620.23028221
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23015969
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21939973
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20436181
125Prion diseases_Homo sapiens_hsa050200.19618818

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