ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	6.65610075
2	fusion of sperm to egg plasma membrane (GO:0007342)	6.54513327
3	acrosome reaction (GO:0007340)	6.51494870
4	regulation of cilium movement (GO:0003352)	6.13161978
5	response to pheromone (GO:0019236)	5.63718975
6	protein targeting to Golgi (GO:0000042)	5.55107440
7	plasma membrane fusion (GO:0045026)	5.44932932
8	protein polyglutamylation (GO:0018095)	5.39276509
9	establishment of protein localization to Golgi (GO:0072600)	5.37030673
10	centriole replication (GO:0007099)	5.15146519
11	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.03528790
12	microtubule depolymerization (GO:0007019)	5.02092594
13	axonemal dynein complex assembly (GO:0070286)	4.83793128
14	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.77167000
15	epithelial cilium movement (GO:0003351)	4.67944656
16	protein localization to Golgi apparatus (GO:0034067)	4.53644425
17	regulation of timing of cell differentiation (GO:0048505)	4.45239020
18	neuron fate determination (GO:0048664)	4.31012383
19	spermatid development (GO:0007286)	4.29706476
20	microtubule polymerization or depolymerization (GO:0031109)	4.28544344
21	cornea development in camera-type eye (GO:0061303)	4.19267126
22	regulation of development, heterochronic (GO:0040034)	4.14835248
23	multicellular organism reproduction (GO:0032504)	4.13621088
24	single strand break repair (GO:0000012)	4.04326590
25	somite development (GO:0061053)	4.03337972
26	calcium ion-dependent exocytosis (GO:0017156)	4.01484053
27	seminiferous tubule development (GO:0072520)	3.95339402
28	regulation of microtubule-based movement (GO:0060632)	3.93196368
29	spermatid nucleus differentiation (GO:0007289)	3.92632104
30	cilium movement (GO:0003341)	3.78867419
31	centriole assembly (GO:0098534)	3.76140400
32	axoneme assembly (GO:0035082)	3.58744088
33	male gamete generation (GO:0048232)	3.54426369
34	spermatogenesis (GO:0007283)	3.53785728
35	sperm-egg recognition (GO:0035036)	3.51734483
36	nonmotile primary cilium assembly (GO:0035058)	3.37831280
37	behavioral response to nicotine (GO:0035095)	3.32766583
38	microtubule severing (GO:0051013)	3.31166139
39	gamete generation (GO:0007276)	3.30025103
40	astrocyte differentiation (GO:0048708)	3.24171783
41	RNA destabilization (GO:0050779)	3.23447846
42	cellular ketone body metabolic process (GO:0046950)	3.22993775
43	reproduction (GO:0000003)	3.22312266
44	regulation of centriole replication (GO:0046599)	3.17098513
45	regulation of transcription involved in cell fate commitment (GO:0060850)	3.14397124
46	indole-containing compound catabolic process (GO:0042436)	3.12909839
47	indolalkylamine catabolic process (GO:0046218)	3.12909839
48	tryptophan catabolic process (GO:0006569)	3.12909839
49	cilium morphogenesis (GO:0060271)	3.11793903
50	smoothened signaling pathway (GO:0007224)	3.10857990
51	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.09158838
52	detection of light stimulus involved in sensory perception (GO:0050962)	3.07818605
53	detection of light stimulus involved in visual perception (GO:0050908)	3.07818605
54	nephron tubule morphogenesis (GO:0072078)	3.05244578
55	nephron epithelium morphogenesis (GO:0072088)	3.05244578
56	cell proliferation in forebrain (GO:0021846)	3.05030063
57	hindbrain development (GO:0030902)	3.04975008
58	DNA packaging (GO:0006323)	2.99439241
59	phosphatidylethanolamine metabolic process (GO:0046337)	2.98669329
60	rRNA methylation (GO:0031167)	2.97061261
61	sperm capacitation (GO:0048240)	2.93576453
62	substrate-independent telencephalic tangential migration (GO:0021826)	2.92749394
63	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.92749394
64	cilium organization (GO:0044782)	2.92258953
65	spinal cord motor neuron differentiation (GO:0021522)	2.91575404
66	positive regulation of gastrulation (GO:2000543)	2.90151694
67	chromosome condensation (GO:0030261)	2.89295292
68	water-soluble vitamin biosynthetic process (GO:0042364)	2.86243389
69	ketone body metabolic process (GO:1902224)	2.85917415
70	positive regulation of cell fate commitment (GO:0010455)	2.85820935
71	synapsis (GO:0007129)	2.84281105
72	photoreceptor cell development (GO:0042461)	2.83642544
73	cilium assembly (GO:0042384)	2.82791643
74	postsynaptic membrane organization (GO:0001941)	2.81719787
75	single fertilization (GO:0007338)	2.80959197
76	cell wall macromolecule catabolic process (GO:0016998)	2.79909707
77	L-fucose catabolic process (GO:0042355)	2.79313462
78	fucose catabolic process (GO:0019317)	2.79313462
79	L-fucose metabolic process (GO:0042354)	2.79313462
80	cell-cell recognition (GO:0009988)	2.78982607
81	brain morphogenesis (GO:0048854)	2.77479621
82	microtubule nucleation (GO:0007020)	2.76132202
83	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.73834438
84	positive regulation of neuroblast proliferation (GO:0002052)	2.71081010
85	rRNA modification (GO:0000154)	2.70316227
86	ribosomal small subunit assembly (GO:0000028)	2.69437134
87	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.68990696
88	DNA deamination (GO:0045006)	2.68724689
89	artery development (GO:0060840)	2.68228441
90	pituitary gland development (GO:0021983)	2.65604565
91	resolution of meiotic recombination intermediates (GO:0000712)	2.65413984
92	positive regulation of respiratory burst (GO:0060267)	2.65365796
93	eye photoreceptor cell development (GO:0042462)	2.64437961
94	motile cilium assembly (GO:0044458)	2.63011008
95	fertilization (GO:0009566)	2.59653478
96	estrogen biosynthetic process (GO:0006703)	2.57861150
97	regulation of meiosis I (GO:0060631)	2.57829972
98	dentate gyrus development (GO:0021542)	2.57400126
99	kynurenine metabolic process (GO:0070189)	2.56791144
100	negative regulation of astrocyte differentiation (GO:0048712)	2.55181334

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.27565294
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.76373461
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70734639
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.55195132
5	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.52611509
6	FUS_26573619_Chip-Seq_HEK293_Human	2.49489457
7	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.37582614
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.26382695
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20423733
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.15589554
11	P300_19829295_ChIP-Seq_ESCs_Human	2.09329932
12	VDR_22108803_ChIP-Seq_LS180_Human	2.04839373
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.94658532
14	CBP_20019798_ChIP-Seq_JUKART_Human	1.93794212
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.93794212
16	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.92700501
17	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.92700501
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.90061583
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.88258951
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.88185035
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.85579804
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83980969
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.82518902
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.76033164
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.75749879
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.71796514
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68988572
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68522346
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.67146119
30	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.65052813
31	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.61822775
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59829910
33	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.58562633
34	EWS_26573619_Chip-Seq_HEK293_Human	1.57432743
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56796440
36	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.52525613
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.52427936
38	AR_25329375_ChIP-Seq_VCAP_Human	1.50171530
39	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.46812415
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45975222
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43078273
42	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42168184
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40837429
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.38668765
45	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.38407221
46	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.38141150
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37437481
48	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.36784322
49	STAT3_23295773_ChIP-Seq_U87_Human	1.36394949
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36050778
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.35733205
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35443405
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33914797
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33127178
55	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.31201799
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30116888
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30116888
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.28493604
59	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.26550856
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.26271577
61	NCOR_22424771_ChIP-Seq_293T_Human	1.26185962
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26042371
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25773642
64	TCF4_23295773_ChIP-Seq_U87_Human	1.25471494
65	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25080908
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.24655649
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24436763
68	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23337862
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23337862
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22570677
71	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.21460880
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19454565
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19389598
74	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17886146
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16472902
76	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.15849701
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14301959
78	ERA_21632823_ChIP-Seq_H3396_Human	1.14294639
79	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13671268
80	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.13119924
81	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12949818
82	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.12366940
83	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.11137601
84	TCF4_22108803_ChIP-Seq_LS180_Human	1.10052105
85	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.09980038
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09968442
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08795936
88	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.08729565
89	PHF8_20622853_ChIP-Seq_HELA_Human	1.08317600
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06715412
91	ETV1_20927104_ChIP-Seq_GIST48_Human	1.06014781
92	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.05250759
93	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05223837
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04660142
95	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04228449
96	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.03812119
97	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03213936
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03172234
99	ERG_20517297_ChIP-Seq_VCAP_Human	1.02978412
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02156082

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.56843287
2	MP0005410_abnormal_fertilization	4.06240965
3	MP0008789_abnormal_olfactory_epithelium	3.48577370
4	MP0003878_abnormal_ear_physiology	2.86871285
5	MP0005377_hearing/vestibular/ear_phenot	2.86871285
6	MP0005499_abnormal_olfactory_system	2.85097402
7	MP0005394_taste/olfaction_phenotype	2.85097402
8	MP0002638_abnormal_pupillary_reflex	2.73703048
9	MP0003787_abnormal_imprinting	2.73477164
10	MP0002938_white_spotting	2.69618042
11	MP0008877_abnormal_DNA_methylation	2.58476820
12	MP0003011_delayed_dark_adaptation	2.44960839
13	MP0001485_abnormal_pinna_reflex	2.44093442
14	MP0002234_abnormal_pharynx_morphology	2.41865154
15	MP0009379_abnormal_foot_pigmentation	2.20124105
16	MP0004885_abnormal_endolymph	2.02057444
17	MP0005551_abnormal_eye_electrophysiolog	1.98674822
18	MP0000566_synostosis	1.89170690
19	MP0004742_abnormal_vestibular_system	1.80755039
20	MP0003698_abnormal_male_reproductive	1.76291172
21	MP0003880_abnormal_central_pattern	1.74557848
22	MP0005253_abnormal_eye_physiology	1.72008174
23	MP0001984_abnormal_olfaction	1.70846928
24	MP0001929_abnormal_gametogenesis	1.62239681
25	MP0001968_abnormal_touch/_nociception	1.60730817
26	MP0000049_abnormal_middle_ear	1.57143151
27	MP0001486_abnormal_startle_reflex	1.55848270
28	MP0003136_yellow_coat_color	1.54278331
29	MP0002102_abnormal_ear_morphology	1.53150369
30	MP0002653_abnormal_ependyma_morphology	1.51296085
31	MP0006072_abnormal_retinal_apoptosis	1.50746782
32	MP0000631_abnormal_neuroendocrine_gland	1.48707482
33	MP0004142_abnormal_muscle_tone	1.42958387
34	MP0005257_abnormal_intraocular_pressure	1.39819824
35	MP0009046_muscle_twitch	1.39484148
36	MP0002557_abnormal_social/conspecific_i	1.39291955
37	MP0009745_abnormal_behavioral_response	1.37696661
38	MP0005379_endocrine/exocrine_gland_phen	1.36840328
39	MP0003121_genomic_imprinting	1.36558958
40	MP0000778_abnormal_nervous_system	1.34619286
41	MP0002272_abnormal_nervous_system	1.32747201
42	MP0000026_abnormal_inner_ear	1.29610818
43	MP0006276_abnormal_autonomic_nervous	1.28222120
44	MP0002837_dystrophic_cardiac_calcinosis	1.25858536
45	MP0005645_abnormal_hypothalamus_physiol	1.24787127
46	MP0004133_heterotaxia	1.24332784
47	MP0002572_abnormal_emotion/affect_behav	1.23786485
48	MP0005423_abnormal_somatic_nervous	1.17749659
49	MP0000427_abnormal_hair_cycle	1.17312879
50	MP0001963_abnormal_hearing_physiology	1.13564438
51	MP0005084_abnormal_gallbladder_morpholo	1.12301167
52	MP0003646_muscle_fatigue	1.08897712
53	MP0002249_abnormal_larynx_morphology	1.06821324
54	MP0002282_abnormal_trachea_morphology	1.06183283
55	MP0002733_abnormal_thermal_nociception	1.05106369
56	MP0002735_abnormal_chemical_nociception	1.04929289
57	MP0005195_abnormal_posterior_eye	1.04679153
58	MP0003938_abnormal_ear_development	1.03577988
59	MP0002210_abnormal_sex_determination	1.03218183
60	MP0005391_vision/eye_phenotype	1.03167837
61	MP0002163_abnormal_gland_morphology	0.99729819
62	MP0001986_abnormal_taste_sensitivity	0.99619942
63	MP0001501_abnormal_sleep_pattern	0.99487113
64	MP0008872_abnormal_physiological_respon	0.98234465
65	MP0000569_abnormal_digit_pigmentation	0.98058935
66	MP0005646_abnormal_pituitary_gland	0.96326304
67	MP0002067_abnormal_sensory_capabilities	0.96118926
68	MP0003195_calcinosis	0.95700482
69	MP0002160_abnormal_reproductive_system	0.94308002
70	MP0002161_abnormal_fertility/fecundity	0.93762011
71	MP0003718_maternal_effect	0.92825000
72	MP0001293_anophthalmia	0.92823768
73	MP0001970_abnormal_pain_threshold	0.91593573
74	MP0003635_abnormal_synaptic_transmissio	0.88134461
75	MP0002752_abnormal_somatic_nervous	0.87940260
76	MP0002064_seizures	0.87646468
77	MP0000613_abnormal_salivary_gland	0.86371282
78	MP0002736_abnormal_nociception_after	0.85021621
79	MP0004859_abnormal_synaptic_plasticity	0.84283910
80	MP0002063_abnormal_learning/memory/cond	0.84190865
81	MP0002928_abnormal_bile_duct	0.83141362
82	MP0001905_abnormal_dopamine_level	0.82464446
83	MP0001944_abnormal_pancreas_morphology	0.81963383
84	MP0000653_abnormal_sex_gland	0.81622877
85	MP0003122_maternal_imprinting	0.81010013
86	MP0001529_abnormal_vocalization	0.78968301
87	MP0000955_abnormal_spinal_cord	0.78923431
88	MP0003283_abnormal_digestive_organ	0.78620112
89	MP0001502_abnormal_circadian_rhythm	0.78352447
90	MP0003937_abnormal_limbs/digits/tail_de	0.76807396
91	MP0002184_abnormal_innervation	0.75886223
92	MP0002734_abnormal_mechanical_nocicepti	0.75254776
93	MP0002876_abnormal_thyroid_physiology	0.75029873
94	MP0001145_abnormal_male_reproductive	0.74326851
95	MP0005670_abnormal_white_adipose	0.70511472
96	MP0002095_abnormal_skin_pigmentation	0.70229000
97	MP0002138_abnormal_hepatobiliary_system	0.69677423
98	MP0002882_abnormal_neuron_morphology	0.69548731
99	MP0001286_abnormal_eye_development	0.69339543
100	MP0001324_abnormal_eye_pigmentation	0.69170741

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.20819931
2	Hypoplasia of the fovea (HP:0007750)	4.20819931
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.75396322
4	Absent/shortened dynein arms (HP:0200106)	3.75396322
5	Optic nerve hypoplasia (HP:0000609)	3.69567125
6	Nephronophthisis (HP:0000090)	3.53885392
7	Abnormal respiratory motile cilium morphology (HP:0005938)	3.53009734
8	Abnormal respiratory epithelium morphology (HP:0012253)	3.53009734
9	Molar tooth sign on MRI (HP:0002419)	3.45050162
10	Abnormality of midbrain morphology (HP:0002418)	3.45050162
11	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	3.38078482
12	Abnormality of macular pigmentation (HP:0008002)	3.36756859
13	Congenital stationary night blindness (HP:0007642)	3.33168896
14	Abnormality of the fovea (HP:0000493)	3.28683386
15	Chronic hepatic failure (HP:0100626)	3.14468393
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.14134925
17	Abnormality of the renal medulla (HP:0100957)	3.11987182
18	Abnormality of the renal cortex (HP:0011035)	3.06195131
19	Severe visual impairment (HP:0001141)	3.05940849
20	True hermaphroditism (HP:0010459)	2.98952352
21	Attenuation of retinal blood vessels (HP:0007843)	2.93289067
22	Pancreatic cysts (HP:0001737)	2.92140174
23	Pancreatic fibrosis (HP:0100732)	2.88096376
24	Type II lissencephaly (HP:0007260)	2.88071621
25	Abnormal ciliary motility (HP:0012262)	2.85600693
26	Intestinal atresia (HP:0011100)	2.84744438
27	Tubulointerstitial nephritis (HP:0001970)	2.81294154
28	Abnormal respiratory motile cilium physiology (HP:0012261)	2.70484322
29	Hyperglycinemia (HP:0002154)	2.59941738
30	Pendular nystagmus (HP:0012043)	2.57401841
31	Oligodactyly (hands) (HP:0001180)	2.53601983
32	Aplasia/Hypoplasia of the macula (HP:0008059)	2.51662385
33	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.49063515
34	Medial flaring of the eyebrow (HP:0010747)	2.42638496
35	Tubular atrophy (HP:0000092)	2.40576790
36	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.36626039
37	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.36157129
38	Esophageal atresia (HP:0002032)	2.34152675
39	Decreased central vision (HP:0007663)	2.34034320
40	Progressive cerebellar ataxia (HP:0002073)	2.31050752
41	Growth hormone deficiency (HP:0000824)	2.30308166
42	Abnormal drinking behavior (HP:0030082)	2.24950635
43	Polydipsia (HP:0001959)	2.24950635
44	Gastrointestinal atresia (HP:0002589)	2.24705498
45	Acute necrotizing encephalopathy (HP:0006965)	2.23207173
46	Septo-optic dysplasia (HP:0100842)	2.20864766
47	Polyuria (HP:0000103)	2.20803309
48	Hypoplasia of the pons (HP:0012110)	2.19303575
49	Bony spicule pigmentary retinopathy (HP:0007737)	2.17880367
50	Oligodactyly (HP:0012165)	2.16844655
51	Cone-rod dystrophy (HP:0000548)	2.16514777
52	Cerebellar dysplasia (HP:0007033)	2.12543245
53	Gait imbalance (HP:0002141)	2.12065209
54	Acute encephalopathy (HP:0006846)	2.10657549
55	Congenital malformation of the right heart (HP:0011723)	2.10562384
56	Double outlet right ventricle (HP:0001719)	2.10562384
57	Optic nerve coloboma (HP:0000588)	2.09984941
58	Bilateral microphthalmos (HP:0007633)	2.07621634
59	Renal cortical cysts (HP:0000803)	2.07348140
60	Colon cancer (HP:0003003)	2.07062503
61	Rhinitis (HP:0012384)	2.06256578
62	Median cleft lip (HP:0000161)	2.05145148
63	Tubulointerstitial abnormality (HP:0001969)	2.04271862
64	Reticulocytopenia (HP:0001896)	2.03636919
65	Abnormality of cochlea (HP:0000375)	2.03236856
66	Adrenal hypoplasia (HP:0000835)	2.00695427
67	Impulsivity (HP:0100710)	1.99726780
68	Renal Fanconi syndrome (HP:0001994)	1.98794539
69	Abnormal urine output (HP:0012590)	1.98216561
70	Abnormality of the pons (HP:0007361)	1.97978099
71	Congenital primary aphakia (HP:0007707)	1.96775557
72	Mitochondrial inheritance (HP:0001427)	1.93666156
73	Renal dysplasia (HP:0000110)	1.91235920
74	Progressive macrocephaly (HP:0004481)	1.90876805
75	Retinal dysplasia (HP:0007973)	1.87244599
76	Anophthalmia (HP:0000528)	1.85991909
77	Postaxial foot polydactyly (HP:0001830)	1.85618981
78	Supernumerary spleens (HP:0009799)	1.84614588
79	Congenital, generalized hypertrichosis (HP:0004540)	1.83224863
80	Focal motor seizures (HP:0011153)	1.82938902
81	Inability to walk (HP:0002540)	1.82603750
82	Abolished electroretinogram (ERG) (HP:0000550)	1.80977664
83	Abnormality of the aortic arch (HP:0012303)	1.80625610
84	Anencephaly (HP:0002323)	1.79233327
85	Abnormal mitochondria in muscle tissue (HP:0008316)	1.78259565
86	Hyperventilation (HP:0002883)	1.78135256
87	Chronic sinusitis (HP:0011109)	1.77131528
88	Sclerocornea (HP:0000647)	1.76291376
89	Amelogenesis imperfecta (HP:0000705)	1.74044531
90	Stage 5 chronic kidney disease (HP:0003774)	1.73843224
91	Genital tract atresia (HP:0001827)	1.73644401
92	Abnormality of urine glucose concentration (HP:0011016)	1.72511726
93	Glycosuria (HP:0003076)	1.72511726
94	Congenital hepatic fibrosis (HP:0002612)	1.71595837
95	Depressed nasal tip (HP:0000437)	1.71311129
96	Nephrogenic diabetes insipidus (HP:0009806)	1.71253011
97	Limb dystonia (HP:0002451)	1.70455156
98	Midline defect of the nose (HP:0004122)	1.70261654
99	Abnormality of renal excretion (HP:0011036)	1.68652459
100	Vaginal atresia (HP:0000148)	1.68618832

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	4.26082311
2	INSRR	4.23236144
3	MAP4K2	3.39458692
4	FRK	3.14637670
5	MAPK13	2.61957432
6	PLK2	2.55261690
7	PNCK	2.39582356
8	STK38L	2.25854152
9	WNK3	2.24415480
10	TNIK	2.21919029
11	TAF1	2.15082129
12	CASK	2.09722009
13	PTK2B	2.06553189
14	ZAK	2.04545042
15	TAOK3	2.03498750
16	MAPK15	1.99818247
17	TLK1	1.80231547
18	ADRBK2	1.77424445
19	GRK1	1.74217479
20	BRSK2	1.70260400
21	MARK1	1.55575572
22	MAP3K4	1.52801203
23	TYRO3	1.43014375
24	DYRK2	1.37647683
25	VRK2	1.34209169
26	BRD4	1.33721739
27	VRK1	1.31595599
28	OXSR1	1.29698717
29	NLK	1.14653159
30	NME1	1.13178002
31	STK39	1.12017512
32	WNK4	1.11320832
33	PRKCG	1.10510274
34	CSNK1G1	1.04148784
35	CDK19	1.04007531
36	CSNK1G3	0.99438459
37	NUAK1	0.95963793
38	STK38	0.95480793
39	CAMK1G	0.94745276
40	CSNK1G2	0.92595127
41	MUSK	0.92476233
42	NTRK3	0.92197298
43	IRAK2	0.92173886
44	HIPK2	0.90877250
45	BMPR1B	0.88104926
46	CDC7	0.87691113
47	PINK1	0.85091428
48	PIK3CG	0.82308686
49	TIE1	0.80871765
50	EPHB2	0.80196794
51	PRKCE	0.76503414
52	WNK1	0.75864050
53	CAMK1	0.75784048
54	PKN1	0.72957016
55	EPHA4	0.72078906
56	BCR	0.71615388
57	KIT	0.71449810
58	DYRK1B	0.70746484
59	BCKDK	0.69324546
60	PAK3	0.67636899
61	NTRK2	0.67523045
62	AKT3	0.67372673
63	DDR2	0.66522878
64	MAP2K7	0.64054602
65	PLK3	0.63526992
66	WEE1	0.62928193
67	CDK3	0.61492421
68	GRK5	0.61452849
69	PRKG1	0.60212463
70	CSNK1A1L	0.59378289
71	BRSK1	0.56742125
72	TESK1	0.55304033
73	CSNK1D	0.52927986
74	CSNK1A1	0.52788248
75	DAPK2	0.52446250
76	PRKACA	0.51800663
77	SGK2	0.50899250
78	PHKG1	0.50437455
79	PHKG2	0.50437455
80	PIK3CA	0.48912696
81	CHEK2	0.47502987
82	CAMKK2	0.43600738
83	STK3	0.43405106
84	FER	0.41041793
85	SGK223	0.40997942
86	SGK494	0.40997942
87	PRKCZ	0.40522369
88	ADRBK1	0.39380334
89	PRKAA2	0.39300402
90	FLT3	0.39180758
91	CAMK2A	0.38480010
92	IRAK1	0.37444231
93	RPS6KA5	0.37279814
94	ACVR1B	0.36035091
95	STK16	0.34677871
96	CAMK1D	0.33812428
97	PLK1	0.32466078
98	TXK	0.30269422
99	CSNK1E	0.30264064
100	MKNK2	0.29674870

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.59597513
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.42283146
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.61584279
4	Phototransduction_Homo sapiens_hsa04744	2.58936244
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.44763605
6	Parkinsons disease_Homo sapiens_hsa05012	2.25028793
7	Butanoate metabolism_Homo sapiens_hsa00650	2.23816831
8	Nicotine addiction_Homo sapiens_hsa05033	2.19627464
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.07705330
10	Olfactory transduction_Homo sapiens_hsa04740	2.02640936
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.97716036
12	Ribosome_Homo sapiens_hsa03010	1.92360390
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.88178156
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.84666211
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.71341027
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70745916
17	Huntingtons disease_Homo sapiens_hsa05016	1.67752296
18	Morphine addiction_Homo sapiens_hsa05032	1.64071027
19	Taste transduction_Homo sapiens_hsa04742	1.53993370
20	RNA polymerase_Homo sapiens_hsa03020	1.52824701
21	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.50834548
22	Homologous recombination_Homo sapiens_hsa03440	1.49212819
23	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.45509787
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.45498655
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.44593759
26	Alzheimers disease_Homo sapiens_hsa05010	1.41540789
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.38795341
28	Insulin secretion_Homo sapiens_hsa04911	1.38000350
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.36185535
30	RNA degradation_Homo sapiens_hsa03018	1.34010011
31	Propanoate metabolism_Homo sapiens_hsa00640	1.27411914
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.25024603
33	Mismatch repair_Homo sapiens_hsa03430	1.18216441
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.18202026
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.17632827
36	GABAergic synapse_Homo sapiens_hsa04727	1.17121611
37	Circadian entrainment_Homo sapiens_hsa04713	1.15583834
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.13010942
39	Retinol metabolism_Homo sapiens_hsa00830	1.10045847
40	Protein export_Homo sapiens_hsa03060	1.08969094
41	Serotonergic synapse_Homo sapiens_hsa04726	1.06608580
42	Type I diabetes mellitus_Homo sapiens_hsa04940	1.05055884
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.04318443
44	Circadian rhythm_Homo sapiens_hsa04710	1.04131819
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01209533
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.99849748
47	RNA transport_Homo sapiens_hsa03013	0.99673978
48	Peroxisome_Homo sapiens_hsa04146	0.95863215
49	Basal cell carcinoma_Homo sapiens_hsa05217	0.93833980
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.93543234
51	Cocaine addiction_Homo sapiens_hsa05030	0.92789485
52	Proteasome_Homo sapiens_hsa03050	0.92186288
53	Sulfur relay system_Homo sapiens_hsa04122	0.90652283
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.89113304
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.87127687
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85376007
57	Basal transcription factors_Homo sapiens_hsa03022	0.84211767
58	Base excision repair_Homo sapiens_hsa03410	0.80567331
59	Amphetamine addiction_Homo sapiens_hsa05031	0.80538115
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77181000
61	Salivary secretion_Homo sapiens_hsa04970	0.76257069
62	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.72882213
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.72406589
64	Purine metabolism_Homo sapiens_hsa00230	0.71332996
65	cAMP signaling pathway_Homo sapiens_hsa04024	0.68896905
66	One carbon pool by folate_Homo sapiens_hsa00670	0.68567352
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68116359
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.65834304
69	Metabolic pathways_Homo sapiens_hsa01100	0.63075656
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60633171
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.60383169
72	Graft-versus-host disease_Homo sapiens_hsa05332	0.59254466
73	Sulfur metabolism_Homo sapiens_hsa00920	0.58739973
74	Regulation of autophagy_Homo sapiens_hsa04140	0.58204092
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57504273
76	Caffeine metabolism_Homo sapiens_hsa00232	0.56515400
77	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55097107
78	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.54871509
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.52815430
80	ABC transporters_Homo sapiens_hsa02010	0.52610215
81	Allograft rejection_Homo sapiens_hsa05330	0.52319797
82	Asthma_Homo sapiens_hsa05310	0.52252909
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.51868987
84	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48034456
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.46603216
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46398879
87	Folate biosynthesis_Homo sapiens_hsa00790	0.46095752
88	DNA replication_Homo sapiens_hsa03030	0.45408912
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44576256
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44115376
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42890462
92	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.42773673
93	Bile secretion_Homo sapiens_hsa04976	0.41030502
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.40952110
95	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.40784127
96	Oocyte meiosis_Homo sapiens_hsa04114	0.39464390
97	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39284738
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38666770
99	Fatty acid degradation_Homo sapiens_hsa00071	0.36827180
100	Renin secretion_Homo sapiens_hsa04924	0.36249189

WBP11P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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