WBP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.58066936
2L-phenylalanine catabolic process (GO:0006559)6.58066936
3L-phenylalanine metabolic process (GO:0006558)6.39473842
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.39473842
5aromatic amino acid family catabolic process (GO:0009074)5.92991344
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.73180785
7alpha-linolenic acid metabolic process (GO:0036109)5.47436328
8kynurenine metabolic process (GO:0070189)5.44726762
9tryptophan catabolic process (GO:0006569)5.37785653
10indole-containing compound catabolic process (GO:0042436)5.37785653
11indolalkylamine catabolic process (GO:0046218)5.37785653
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.31042992
13negative regulation of fibrinolysis (GO:0051918)5.30200343
14glyoxylate metabolic process (GO:0046487)5.28395026
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.20699204
16bile acid biosynthetic process (GO:0006699)5.15901993
17peptidyl-glutamic acid carboxylation (GO:0017187)5.13810903
18protein carboxylation (GO:0018214)5.13810903
19urea metabolic process (GO:0019627)5.09422191
20urea cycle (GO:0000050)5.09422191
21sulfur amino acid catabolic process (GO:0000098)5.07083216
22tryptophan metabolic process (GO:0006568)5.06364945
23cysteine metabolic process (GO:0006534)5.00200228
24complement activation, alternative pathway (GO:0006957)5.00055100
25high-density lipoprotein particle remodeling (GO:0034375)4.99370964
26regulation of protein activation cascade (GO:2000257)4.92951753
27regulation of fibrinolysis (GO:0051917)4.91525449
28antigen processing and presentation of endogenous antigen (GO:0019883)4.79043768
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78834140
30regulation of complement activation (GO:0030449)4.64377698
31nitrogen cycle metabolic process (GO:0071941)4.63936865
32serine family amino acid catabolic process (GO:0009071)4.59617829
33lysine catabolic process (GO:0006554)4.56761706
34lysine metabolic process (GO:0006553)4.56761706
35homocysteine metabolic process (GO:0050667)4.54036277
36regulation of triglyceride catabolic process (GO:0010896)4.52822241
37reverse cholesterol transport (GO:0043691)4.44095954
38bile acid metabolic process (GO:0008206)4.42775910
39amino-acid betaine metabolic process (GO:0006577)4.35514115
40negative regulation of sterol transport (GO:0032372)4.30316945
41negative regulation of cholesterol transport (GO:0032375)4.30316945
42plasma lipoprotein particle clearance (GO:0034381)4.29937357
43aromatic amino acid family metabolic process (GO:0009072)4.28728269
44plasma lipoprotein particle remodeling (GO:0034369)4.24588676
45protein-lipid complex remodeling (GO:0034368)4.24588676
46macromolecular complex remodeling (GO:0034367)4.24588676
47regulation of cholesterol esterification (GO:0010872)4.23718711
48phospholipid efflux (GO:0033700)4.22558024
49triglyceride homeostasis (GO:0070328)4.22179933
50acylglycerol homeostasis (GO:0055090)4.22179933
51tyrosine metabolic process (GO:0006570)4.13552471
52alpha-amino acid catabolic process (GO:1901606)4.12483082
53regulation of cholesterol homeostasis (GO:2000188)4.04848055
54glycine metabolic process (GO:0006544)3.91819946
55ethanol oxidation (GO:0006069)3.87583724
56cellular modified amino acid catabolic process (GO:0042219)3.84456188
57barbed-end actin filament capping (GO:0051016)3.83295717
58bile acid and bile salt transport (GO:0015721)3.82920820
59cellular amino acid catabolic process (GO:0009063)3.81429178
60fibrinolysis (GO:0042730)3.79098937
61plasma lipoprotein particle assembly (GO:0034377)3.77681600
62cholesterol efflux (GO:0033344)3.76719332
63coenzyme catabolic process (GO:0009109)3.75531134
64benzene-containing compound metabolic process (GO:0042537)3.74356040
65serine family amino acid metabolic process (GO:0009069)3.73533720
66positive regulation of fatty acid beta-oxidation (GO:0032000)3.73286786
67positive regulation of lipoprotein lipase activity (GO:0051006)3.71527924
68positive regulation of triglyceride lipase activity (GO:0061365)3.71527924
69cellular ketone body metabolic process (GO:0046950)3.71462564
70glutamate metabolic process (GO:0006536)3.69763316
71phospholipid homeostasis (GO:0055091)3.69383862
72cellular glucuronidation (GO:0052695)3.68324631
73indolalkylamine metabolic process (GO:0006586)3.67532476
74positive regulation of lipid catabolic process (GO:0050996)3.67226604
75dicarboxylic acid biosynthetic process (GO:0043650)3.64158590
762-oxoglutarate metabolic process (GO:0006103)3.62400207
77imidazole-containing compound metabolic process (GO:0052803)3.61475160
78amine catabolic process (GO:0009310)3.58966966
79cellular biogenic amine catabolic process (GO:0042402)3.58966966
80arginine metabolic process (GO:0006525)3.57655626
81cholesterol homeostasis (GO:0042632)3.55283506
82protein-lipid complex assembly (GO:0065005)3.51533186
83sterol homeostasis (GO:0055092)3.51222825
84serine family amino acid biosynthetic process (GO:0009070)3.49966956
85acetyl-CoA metabolic process (GO:0006084)3.49665510
86neutrophil activation involved in immune response (GO:0002283)3.49404123
87negative regulation of lipase activity (GO:0060192)3.49339605
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49038151
89drug catabolic process (GO:0042737)3.45257239
90complement activation, classical pathway (GO:0006958)3.44120403
91complement activation (GO:0006956)3.44086823
92valine metabolic process (GO:0006573)3.43797462
93acute-phase response (GO:0006953)3.42839283
94modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40951522
95positive regulation by organism of defense response of other organism involved in symbiotic interact3.40951522
96modulation by symbiont of host immune response (GO:0052553)3.40951522
97positive regulation by symbiont of host defense response (GO:0052509)3.40951522
98modulation by symbiont of host defense response (GO:0052031)3.40951522
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40951522
100very-low-density lipoprotein particle assembly (GO:0034379)3.40895954
101organic acid catabolic process (GO:0016054)3.38895264
102carboxylic acid catabolic process (GO:0046395)3.38895264
103protein activation cascade (GO:0072376)3.38031214
104regulation of fatty acid beta-oxidation (GO:0031998)3.37021099
105fatty acid beta-oxidation (GO:0006635)3.35541007
106lipoprotein metabolic process (GO:0042157)3.34363057
107negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34333631
108negative regulation of cell killing (GO:0031342)3.34333631
109fatty acid oxidation (GO:0019395)3.34320129
110plasma lipoprotein particle organization (GO:0071827)3.33799186
111short-chain fatty acid metabolic process (GO:0046459)3.30473787
112regulation of plasminogen activation (GO:0010755)3.29461278
113epoxygenase P450 pathway (GO:0019373)3.29134443
114positive regulation of triglyceride metabolic process (GO:0090208)3.29116522
115negative regulation of erythrocyte differentiation (GO:0045647)3.26349013
116detection of other organism (GO:0098543)3.24622762
117detection of molecule of bacterial origin (GO:0032490)3.18492973
118positive regulation of receptor recycling (GO:0001921)3.17393977
119detection of bacterium (GO:0016045)3.04221111
120detection of external biotic stimulus (GO:0098581)3.03754144
121response to peptidoglycan (GO:0032494)2.94918411
122protein localization to endosome (GO:0036010)2.94897671
123macrophage activation involved in immune response (GO:0002281)2.92839658
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.80890400
125regulation of early endosome to late endosome transport (GO:2000641)2.79090724
126fibril organization (GO:0097435)2.71616105
127stress fiber assembly (GO:0043149)2.62389231
128positive regulation of gamma-delta T cell activation (GO:0046645)2.62322524
129detection of biotic stimulus (GO:0009595)2.62099280
130regulation of leukocyte degranulation (GO:0043300)2.60475173
131regulation of extracellular matrix disassembly (GO:0010715)2.56024556
132positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.55687623
133regulation of mast cell degranulation (GO:0043304)2.55183972
134positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.53734393
135negative regulation of homotypic cell-cell adhesion (GO:0034111)2.53674730
136extracellular fibril organization (GO:0043206)2.51674174
137negative regulation of interleukin-12 production (GO:0032695)2.49280221
138regulation of macrophage cytokine production (GO:0010935)2.48328215
139germinal center formation (GO:0002467)2.48195130
140regulation of myeloid leukocyte mediated immunity (GO:0002886)2.46409171
141regulation of tolerance induction (GO:0002643)2.46119229
142positive regulation of cellular amide metabolic process (GO:0034250)2.44928728
143regulation of T-helper 2 cell differentiation (GO:0045628)2.43910886
144apoptotic cell clearance (GO:0043277)2.43626987
145positive regulation of extracellular matrix organization (GO:1903055)2.43103987
146response to laminar fluid shear stress (GO:0034616)2.42893960
147regulation of T cell tolerance induction (GO:0002664)2.41246863
148positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40388515
149skin morphogenesis (GO:0043589)2.37864209
150endothelium development (GO:0003158)2.37074625
151NIK/NF-kappaB signaling (GO:0038061)2.36312999
152cellular response to thyroid hormone stimulus (GO:0097067)2.35664407
153negative regulation of stress fiber assembly (GO:0051497)2.34182485
154peptide catabolic process (GO:0043171)2.34041926
155neutrophil activation (GO:0042119)2.33174010
156regulation of mast cell activation involved in immune response (GO:0033006)2.29275602
157response to host (GO:0075136)2.29167397
158response to host defenses (GO:0052200)2.29167397
159response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.29167397
160leukocyte aggregation (GO:0070486)2.28205443
161negative regulation of protein localization to plasma membrane (GO:1903077)2.28113252
162leukocyte migration involved in inflammatory response (GO:0002523)2.27124842
163positive regulation of leukocyte degranulation (GO:0043302)2.27110535
164keratan sulfate catabolic process (GO:0042340)2.26795843
165granulocyte activation (GO:0036230)2.25363077
166cellular extravasation (GO:0045123)2.24877252
167angiogenesis involved in wound healing (GO:0060055)2.24168341
168regulation of interferon-beta biosynthetic process (GO:0045357)2.22995083
169positive regulation of tolerance induction (GO:0002645)2.22930691
170positive regulation of mast cell activation (GO:0033005)2.18233932
171hypotonic response (GO:0006971)2.14939831
172positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.13606091
173positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.13399961
174response to host immune response (GO:0052572)2.12487323
175response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.12487323
176macrophage activation (GO:0042116)2.12259275
177positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.11987203
178phagocytosis, engulfment (GO:0006911)2.11948164
179lipopolysaccharide-mediated signaling pathway (GO:0031663)2.10980064
180immunoglobulin mediated immune response (GO:0016064)2.09919150
181pinocytosis (GO:0006907)2.08563062
182regulation of platelet aggregation (GO:0090330)2.07782386
183regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.07522477
184regulation of regulated secretory pathway (GO:1903305)2.07516488
185response to muramyl dipeptide (GO:0032495)2.07319584
186production of molecular mediator involved in inflammatory response (GO:0002532)2.05571374
187negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.05487159
188blood vessel maturation (GO:0001955)2.05132439
189negative regulation of type 2 immune response (GO:0002829)2.04844076
190epithelial cell differentiation involved in prostate gland development (GO:0060742)2.04749045
191mannose metabolic process (GO:0006013)2.04659188
192negative regulation of granulocyte differentiation (GO:0030853)2.03735351
193cellular response to epinephrine stimulus (GO:0071872)2.03508791
194regulation of dendritic cell antigen processing and presentation (GO:0002604)2.03375679
195positive regulation of tumor necrosis factor production (GO:0032760)2.02293107
196regulation of membrane protein ectodomain proteolysis (GO:0051043)2.01827265
197positive regulation of macrophage cytokine production (GO:0060907)1.99828025
198positive regulation of mast cell activation involved in immune response (GO:0033008)1.99341581
199positive regulation of mast cell degranulation (GO:0043306)1.99341581
200positive regulation of myeloid leukocyte mediated immunity (GO:0002888)1.97806363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.16515148
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.32793407
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.61890252
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.18160472
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.17667207
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.38899655
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.95886460
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.53591769
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.00551903
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42292509
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.38732204
12CLOCK_20551151_ChIP-Seq_293T_Human2.36671382
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10408128
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00258468
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0305684
16IRF8_21731497_ChIP-ChIP_J774_Mouse1.89132568
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87677637
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.84300531
19VDR_24763502_ChIP-Seq_THP-1_Human1.81505734
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79104143
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78037429
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73640001
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.70241222
24SPI1_23127762_ChIP-Seq_K562_Human1.69762367
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.69368480
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69051268
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68340962
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.66765424
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61578360
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55658066
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.52260963
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.47554525
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.47168433
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44663923
35RUNX_20019798_ChIP-Seq_JUKART_Human1.43535042
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41523882
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39929160
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38603018
39VDR_24787735_ChIP-Seq_THP-1_Human1.35876307
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.33379215
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32579656
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32264802
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30565213
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30484040
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28022154
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.25145692
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23995754
48HNF4A_19822575_ChIP-Seq_HepG2_Human1.23341727
49LXR_22292898_ChIP-Seq_THP-1_Human1.22221204
50SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19865800
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19819618
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17484956
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17269845
54KDM2B_26808549_Chip-Seq_K562_Human1.17081844
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16769073
56ZNF263_19887448_ChIP-Seq_K562_Human1.15894311
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12413151
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.10679875
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10373190
60UTX_26944678_Chip-Seq_JUKART_Human1.10359628
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09922730
62GATA1_22025678_ChIP-Seq_K562_Human1.09574000
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.07654320
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.05684379
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05571764
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05560120
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03035828
68RACK7_27058665_Chip-Seq_MCF-7_Human1.02597303
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02070062
70SPI1_23547873_ChIP-Seq_NB4_Human1.00518522
71RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00391201
72GATA4_25053715_ChIP-Seq_YYC3_Human0.99939569
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99742170
74TRIM28_21343339_ChIP-Seq_HEK293_Human0.99729344
75CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99465882
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99424405
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99424405
78GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99209408
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99174090
80CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99114328
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98966499
82FOXO3_23340844_ChIP-Seq_DLD1_Human0.98258151
83STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98017760
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97942582
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97917049
86STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97850926
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96915627
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96092073
89BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94551247
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93748222
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93558823
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93291577
93PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93234759
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91299446
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88481903
96GATA6_25053715_ChIP-Seq_YYC3_Human0.81730893
97ATF3_27146783_Chip-Seq_COLON_Human0.81356907
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81042253
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.80941205
100TBX20_22080862_ChIP-Seq_HEART_Mouse0.80941205
101SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80799121
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80298449
103GATA1_19941826_ChIP-Seq_K562_Human0.80001082
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79101892
105TCF7_22412390_ChIP-Seq_EML_Mouse0.77403045
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.76708361
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.76574168
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76130538
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74362233
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72967096
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.72291824
112GATA2_19941826_ChIP-Seq_K562_Human0.71827694
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71741679
114IRF8_27001747_Chip-Seq_BMDM_Mouse0.71236789
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.70794556
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70202854
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.70153565
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.69646706
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69545843
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.67936192
121HIF1A_21447827_ChIP-Seq_MCF-7_Human0.67431677
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.67086039
123MAF_26560356_Chip-Seq_TH1_Human0.66951429
124RARA_24833708_ChIP-Seq_LIVER_Mouse0.66624601
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.66177691
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66144828
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.65428609
128MYC_22102868_ChIP-Seq_BL_Human0.65349056
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.64262666
130SCL_19346495_ChIP-Seq_HPC-7_Human0.64241446
131HTT_18923047_ChIP-ChIP_STHdh_Human0.63861451
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.63455959
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.62896967
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.62170132
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.60637290
136VDR_21846776_ChIP-Seq_THP-1_Human0.59532153
137EGR1_19032775_ChIP-ChIP_M12_Human0.59457836
138KDM2B_26808549_Chip-Seq_DND41_Human0.59118076
139BCOR_27268052_Chip-Seq_Bcells_Human0.59009556
140NCOR1_26117541_ChIP-Seq_K562_Human0.58379843
141PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58366010
142CEBPB_22108803_ChIP-Seq_LS180_Human0.57831777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.99629340
2MP0005360_urolithiasis6.46262111
3MP0005365_abnormal_bile_salt5.33763080
4MP0005085_abnormal_gallbladder_physiolo5.33144737
5MP0008875_abnormal_xenobiotic_pharmacok4.22216963
6MP0009840_abnormal_foam_cell3.52866640
7MP0003252_abnormal_bile_duct3.48642975
8MP0003806_abnormal_nucleotide_metabolis3.45660134
9MP0010329_abnormal_lipoprotein_level3.25799773
10MP0005083_abnormal_biliary_tract2.84145635
11MP0003191_abnormal_cellular_cholesterol2.74968018
12MP0003705_abnormal_hypodermis_morpholog2.49903731
13MP0005332_abnormal_amino_acid2.40452797
14MP0001835_abnormal_antigen_presentation2.36957760
15MP0001666_abnormal_nutrient_absorption2.36266210
16MP0001958_emphysema2.26280850
17MP0003195_calcinosis2.23884565
18MP0000609_abnormal_liver_physiology2.12277667
19MP0003828_pulmonary_edema1.99455906
20MP0006054_spinal_hemorrhage1.94592528
21MP0002118_abnormal_lipid_homeostasis1.91419677
22MP0002419_abnormal_innate_immunity1.91041057
23MP0004019_abnormal_vitamin_homeostasis1.84830140
24MP0002138_abnormal_hepatobiliary_system1.84573923
25MP0005319_abnormal_enzyme/_coenzyme1.75816509
26MP0002998_abnormal_bone_remodeling1.69693004
27MP0003091_abnormal_cell_migration1.68164390
28MP0003172_abnormal_lysosome_physiology1.65282827
29MP0008260_abnormal_autophagy1.63797615
30MP0005025_abnormal_response_to1.61000952
31MP0005503_abnormal_tendon_morphology1.54835934
32MP0010368_abnormal_lymphatic_system1.53576903
33MP0003868_abnormal_feces_composition1.53355983
34MP0001790_abnormal_immune_system1.51015486
35MP0005387_immune_system_phenotype1.51015486
36MP0000343_altered_response_to1.49708096
37MP0000858_altered_metastatic_potential1.48404893
38MP0005451_abnormal_body_composition1.47562487
39MP0000465_gastrointestinal_hemorrhage1.47118464
40MP0004272_abnormal_basement_membrane1.46631561
41MP0002148_abnormal_hypersensitivity_rea1.45484182
42MP0008004_abnormal_stomach_pH1.44470635
43MP0004883_abnormal_blood_vessel1.43177537
44MP0009785_altered_susceptibility_to1.40782000
45MP0005000_abnormal_immune_tolerance1.40588745
46MP0005584_abnormal_enzyme/coenzyme_acti1.35465119
47MP0004510_myositis1.34381646
48MP0005164_abnormal_response_to1.32555117
49MP0009643_abnormal_urine_homeostasis1.29384906
50MP0001542_abnormal_bone_strength1.28353747
51MP0003448_altered_tumor_morphology1.28344287
52MP0002877_abnormal_melanocyte_morpholog1.27679584
53MP0000598_abnormal_liver_morphology1.26305214
54MP0008438_abnormal_cutaneous_collagen1.25958074
55MP0002254_reproductive_system_inflammat1.25584056
56MP0005670_abnormal_white_adipose1.24853816
57MP0005257_abnormal_intraocular_pressure1.24498791
58MP0002452_abnormal_antigen_presenting1.23368314
59MP0001849_ear_inflammation1.21610259
60MP0010155_abnormal_intestine_physiology1.21335029
61MP0002723_abnormal_immune_serum1.16760052
62MP0005390_skeleton_phenotype1.14459788
63MP0001764_abnormal_homeostasis1.13958205
64MP0002420_abnormal_adaptive_immunity1.12704389
65MP0001800_abnormal_humoral_immune1.11727157
66MP0001819_abnormal_immune_cell1.11533181
67MP0001851_eye_inflammation1.08908632
68MP0002896_abnormal_bone_mineralization1.05613575
69MP0003186_abnormal_redox_activity1.05499324
70MP0004130_abnormal_muscle_cell1.04956141
71MP0009764_decreased_sensitivity_to1.04568998
72MP0003656_abnormal_erythrocyte_physiolo1.04273866
73MP0003183_abnormal_peptide_metabolism1.02803843
74MP0003300_gastrointestinal_ulcer1.01853525
75MP0003011_delayed_dark_adaptation1.01645590
76MP0005595_abnormal_vascular_smooth1.00215260
77MP0009763_increased_sensitivity_to0.98569855
78MP0002405_respiratory_system_inflammati0.97435360
79MP0008469_abnormal_protein_level0.94919884
80MP0005409_darkened_coat_color0.94887407
81MP0000604_amyloidosis0.94735587
82MP0004858_abnormal_nervous_system0.93178314
83MP0005671_abnormal_response_to0.92073704
84MP0003795_abnormal_bone_structure0.90509769
85MP0005647_abnormal_sex_gland0.90084437
86MP0005397_hematopoietic_system_phenotyp0.88791749
87MP0001545_abnormal_hematopoietic_system0.88791749
88MP0009697_abnormal_copulation0.88132213
89MP0005666_abnormal_adipose_tissue0.87305277
90MP0009278_abnormal_bone_marrow0.85887705
91MP0003436_decreased_susceptibility_to0.84366303
92MP0005023_abnormal_wound_healing0.83667677
93MP0002933_joint_inflammation0.83650385
94MP0002971_abnormal_brown_adipose0.82843612
95MP0005388_respiratory_system_phenotype0.82251958
96MP0002133_abnormal_respiratory_system0.82251958
97MP0005275_abnormal_skin_tensile0.81305152
98MP0005165_increased_susceptibility_to0.80589364
99MP0005464_abnormal_platelet_physiology0.80470456
100MP0000751_myopathy0.80055182
101MP0004381_abnormal_hair_follicle0.79897296
102MP0001879_abnormal_lymphatic_vessel0.79250294
103MP0000750_abnormal_muscle_regeneration0.79172878
104MP0009642_abnormal_blood_homeostasis0.79092143
105MP0005058_abnormal_lysosome_morphology0.78174723
106MP0005501_abnormal_skin_physiology0.76942228
107MP0009384_cardiac_valve_regurgitation0.75466652
108MP0002060_abnormal_skin_morphology0.75341451
109MP0005636_abnormal_mineral_homeostasis0.75316692
110MP0005076_abnormal_cell_differentiation0.74956239
111MP0009053_abnormal_anal_canal0.74857191
112MP0003566_abnormal_cell_adhesion0.74658355
113MP0005334_abnormal_fat_pad0.73423042
114MP0005508_abnormal_skeleton_morphology0.73062135
115MP0005220_abnormal_exocrine_pancreas0.72407396
116MP0002132_abnormal_respiratory_system0.72302442
117MP0005408_hypopigmentation0.72063636
118MP0001756_abnormal_urination0.70988090
119MP0002796_impaired_skin_barrier0.68560033
120MP0004185_abnormal_adipocyte_glucose0.67766556
121MP0004947_skin_inflammation0.66639285
122MP0002136_abnormal_kidney_physiology0.65029714
123MP0003279_aneurysm0.63887708
124MP0002078_abnormal_glucose_homeostasis0.62872731
125MP0003453_abnormal_keratinocyte_physiol0.62853580
126MP0005376_homeostasis/metabolism_phenot0.61285413
127MP0010234_abnormal_vibrissa_follicle0.59842783
128MP0001243_abnormal_dermal_layer0.59583853
129MP0000249_abnormal_blood_vessel0.59296214
130MP0009115_abnormal_fat_cell0.59176718
131MP0003724_increased_susceptibility_to0.58788751
132MP0002168_other_aberrant_phenotype0.57464438
133MP0006082_CNS_inflammation0.56960368
134MP0009765_abnormal_xenobiotic_induced0.56678165
135MP0001661_extended_life_span0.56067230
136MP0000685_abnormal_immune_system0.55162442
137MP0001853_heart_inflammation0.54752491
138MP0006036_abnormal_mitochondrial_physio0.54278933
139MP0002837_dystrophic_cardiac_calcinosis0.51773425
140MP0001915_intracranial_hemorrhage0.50258440
141MP0001845_abnormal_inflammatory_respons0.49971335
142MP0002928_abnormal_bile_duct0.47906363
143MP0005375_adipose_tissue_phenotype0.47831244
144MP0000639_abnormal_adrenal_gland0.47770242
145MP0003075_altered_response_to0.47544166
146MP0005084_abnormal_gallbladder_morpholo0.46684123
147MP0005166_decreased_susceptibility_to0.46446627
148MP0001533_abnormal_skeleton_physiology0.46143896
149MP0003690_abnormal_glial_cell0.45936695
150MP0005395_other_phenotype0.44849948
151MP0002128_abnormal_blood_circulation0.44658990
152MP0003303_peritoneal_inflammation0.44545262
153MP0005266_abnormal_metabolism0.44330308
154MP0005448_abnormal_energy_balance0.43915406
155MP0003638_abnormal_response/metabolism_0.43902748
156MP0002970_abnormal_white_adipose0.43621222
157MP0005167_abnormal_blood-brain_barrier0.43121984
158MP0000767_abnormal_smooth_muscle0.42702360
159MP0001881_abnormal_mammary_gland0.42688832
160MP0002135_abnormal_kidney_morphology0.42355805

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.00525066
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.24592795
3Intrahepatic cholestasis (HP:0001406)6.21994823
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.89629201
5Xanthomatosis (HP:0000991)5.88839124
6Hypobetalipoproteinemia (HP:0003563)5.38734655
7Prolonged partial thromboplastin time (HP:0003645)5.29937071
8Hyperlipoproteinemia (HP:0010980)5.15552573
9Complement deficiency (HP:0004431)4.99747123
10Hypolipoproteinemia (HP:0010981)4.32149144
11Joint hemorrhage (HP:0005261)4.23748925
12Hyperammonemia (HP:0001987)4.21659438
13Abnormality of the common coagulation pathway (HP:0010990)4.18410696
14Hypoalphalipoproteinemia (HP:0003233)4.06057295
15Eczematoid dermatitis (HP:0000976)4.02560034
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.02366221
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.97245830
18Epidermoid cyst (HP:0200040)3.94289931
19Ketosis (HP:0001946)3.90193530
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.84228996
21Abnormality of complement system (HP:0005339)3.72535027
22Hyperglycinemia (HP:0002154)3.65573950
23Hyperglycinuria (HP:0003108)3.57521286
24Hypoglycemic coma (HP:0001325)3.54224160
25Abnormality of methionine metabolism (HP:0010901)3.50398878
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.49502274
27Abnormality of the nasal mucosa (HP:0000433)3.48662432
28Abnormality of serine family amino acid metabolism (HP:0010894)3.47544824
29Abnormality of glycine metabolism (HP:0010895)3.47544824
30Fat malabsorption (HP:0002630)3.46924920
31Abnormality of the intrinsic pathway (HP:0010989)3.41747618
32Myocardial infarction (HP:0001658)3.38997930
33Hypercholesterolemia (HP:0003124)3.38195853
34Abnormality of macrophages (HP:0004311)3.32743200
35Aortic aneurysm (HP:0004942)3.28749495
36Nasal polyposis (HP:0100582)3.19758771
37Vascular tortuosity (HP:0004948)3.18429701
38Abnormality of fatty-acid metabolism (HP:0004359)3.16417661
39Abnormality of pyrimidine metabolism (HP:0004353)3.13219591
40Recurrent abscess formation (HP:0002722)3.11481293
41Spontaneous hematomas (HP:0007420)3.09546769
42Premature rupture of membranes (HP:0001788)3.08856341
43Abnormality of liposaccharide metabolism (HP:0010968)3.05299698
44Abnormality of glycosphingolipid metabolism (HP:0004343)3.05299698
45Abnormality of glycolipid metabolism (HP:0010969)3.05299698
46Arterial tortuosity (HP:0005116)3.04366024
47Recurrent bacterial skin infections (HP:0005406)3.03358359
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02247476
49Chronic otitis media (HP:0000389)2.97893316
50Systemic lupus erythematosus (HP:0002725)2.95359938
51Hepatocellular carcinoma (HP:0001402)2.88379958
52Aortic dissection (HP:0002647)2.84722626
53Abnormality of nucleobase metabolism (HP:0010932)2.82974962
54Dysostosis multiplex (HP:0000943)2.80686884
55Ketoacidosis (HP:0001993)2.77595584
56Skin nodule (HP:0200036)2.72712573
57Hyperbilirubinemia (HP:0002904)2.71925811
58Abnormality of purine metabolism (HP:0004352)2.67852648
59Esophageal varix (HP:0002040)2.66909182
60Conjugated hyperbilirubinemia (HP:0002908)2.66325444
61Mitral stenosis (HP:0001718)2.63886218
62Steatorrhea (HP:0002570)2.61891907
63Vascular calcification (HP:0004934)2.59480457
64Spontaneous abortion (HP:0005268)2.58273252
65Spastic diplegia (HP:0001264)2.58096854
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.57173919
67Osteolytic defects of the hand bones (HP:0009699)2.57173919
68Emphysema (HP:0002097)2.56003818
69Delayed CNS myelination (HP:0002188)2.55463561
70Dilatation of the ascending aorta (HP:0005111)2.54238965
71Increased IgE level (HP:0003212)2.53247756
72Vertebral compression fractures (HP:0002953)2.53214270
73Purpura (HP:0000979)2.51606515
74Cerebral aneurysm (HP:0004944)2.51045619
75Increased variability in muscle fiber diameter (HP:0003557)2.50977019
76Cardiovascular calcification (HP:0011915)2.47563924
77Asymmetric septal hypertrophy (HP:0001670)2.45660829
78Gout (HP:0001997)2.44070468
79Cervical subluxation (HP:0003308)2.43181894
80Spondylolisthesis (HP:0003302)2.43032868
81Distal lower limb muscle weakness (HP:0009053)2.42642158
82Abnormality of serum amino acid levels (HP:0003112)2.41174282
83Gingival bleeding (HP:0000225)2.38991987
84Gingivitis (HP:0000230)2.38523705
85Abnormality of skeletal muscle fiber size (HP:0012084)2.36709446
86Metabolic acidosis (HP:0001942)2.33489252
87Increased connective tissue (HP:0009025)2.32974281
88Prolonged bleeding time (HP:0003010)2.31268492
89Glomerulonephritis (HP:0000099)2.30318086
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30268058
91Dicarboxylic aciduria (HP:0003215)2.30268058
92Type 1 muscle fiber predominance (HP:0003803)2.28807925
93Hemorrhage of the eye (HP:0011885)2.27106536
94Menorrhagia (HP:0000132)2.25790733
95Neonatal onset (HP:0003623)2.25687100
96Cholelithiasis (HP:0001081)2.25369487
97Recurrent gram-negative bacterial infections (HP:0005420)2.25280444
98Mucopolysacchariduria (HP:0008155)2.22859419
99Urinary glycosaminoglycan excretion (HP:0003541)2.22859419
100Abnormality of polysaccharide metabolism (HP:0011012)2.22674455
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22674455
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22674455
103Myositis (HP:0100614)2.22564583
104Abnormal gallbladder morphology (HP:0012437)2.21820998
105Abnormality of proline metabolism (HP:0010907)2.18956815
106Hydroxyprolinuria (HP:0003080)2.18956815
107Hypochromic microcytic anemia (HP:0004840)2.18780031
108Malnutrition (HP:0004395)2.18701864
109Aneurysm (HP:0002617)2.15915572
110Late onset (HP:0003584)2.14917118
111Epistaxis (HP:0000421)2.14614044
112Increased cerebral lipofuscin (HP:0011813)2.14112647
113Axonal loss (HP:0003447)2.12793923
114Joint stiffness (HP:0001387)2.11793887
115Thrombophlebitis (HP:0004418)2.11500114
116Abnormal cartilage morphology (HP:0002763)2.11257635
117Amyloidosis (HP:0011034)2.11192844
118Orchitis (HP:0100796)2.10014695
119Neurofibrillary tangles (HP:0002185)2.09832200
120Cellulitis (HP:0100658)2.09072270
121Abnormality of iron homeostasis (HP:0011031)2.08916440
122Blue sclerae (HP:0000592)2.08629816
123Recurrent bronchitis (HP:0002837)2.04550761
124Hyporeflexia of lower limbs (HP:0002600)2.03555757
125Polycythemia (HP:0001901)2.03481837
126Vacuolated lymphocytes (HP:0001922)2.03420890
127Abnormality of transition element cation homeostasis (HP:0011030)2.03318848
128Hypoglycemic seizures (HP:0002173)2.00476694
129Lethargy (HP:0001254)1.99891860
130Pancreatitis (HP:0001733)1.98963193
131Abnormal platelet volume (HP:0011876)1.98801612
132Nephritis (HP:0000123)1.97962213
133Genu recurvatum (HP:0002816)1.97368175
134Cholecystitis (HP:0001082)1.96262686
135Abnormal gallbladder physiology (HP:0012438)1.96262686
136Gastrointestinal infarctions (HP:0005244)1.95982517
137Peritonitis (HP:0002586)1.95864824
138Ovoid vertebral bodies (HP:0003300)1.92955435
139Acanthocytosis (HP:0001927)1.92665022
140Recurrent skin infections (HP:0001581)1.91238057
141Irritability (HP:0000737)1.91025494
142Mitral valve prolapse (HP:0001634)1.90073052
143Back pain (HP:0003418)1.89795331
144Broad metatarsal (HP:0001783)1.89692790
145Sensorimotor neuropathy (HP:0007141)1.89275818
146Protrusio acetabuli (HP:0003179)1.88972754
147Abnormality of the Achilles tendon (HP:0005109)1.88317428
148Spinal rigidity (HP:0003306)1.88296983
149Thin bony cortex (HP:0002753)1.84478647
150Atrophic scars (HP:0001075)1.84350434
151Increased mean platelet volume (HP:0011877)1.83974301
152Abnormal enzyme/coenzyme activity (HP:0012379)1.83660963
153Petechiae (HP:0000967)1.82044749
154Slender build (HP:0001533)1.81156084
155Hypertriglyceridemia (HP:0002155)1.81065406
156Muscle fiber splitting (HP:0003555)1.80563161
157Abnormality of the gallbladder (HP:0005264)1.79768165
158Pulmonary embolism (HP:0002204)1.79164820
159Ectopia lentis (HP:0001083)1.78613544
160Loss of speech (HP:0002371)1.77851430
161Increased serum ferritin (HP:0003281)1.77440241
162Stroke (HP:0001297)1.77023534
163Generalized aminoaciduria (HP:0002909)1.75748306
164Cerebral inclusion bodies (HP:0100314)1.75509331
165Hematochezia (HP:0002573)1.75041864
166Hyperglycemia (HP:0003074)1.75017871
167Lymphangioma (HP:0100764)1.74871387
168Right ventricular cardiomyopathy (HP:0011663)1.74600773
169Mediastinal lymphadenopathy (HP:0100721)1.73927629
170Fragile skin (HP:0001030)1.73512773
171Ulnar deviation of the wrist (HP:0003049)1.72712637
172Thick nail (HP:0001805)1.72705239
173Vomiting (HP:0002013)1.72637363
174Ankle contracture (HP:0006466)1.70796107
175Generalized amyotrophy (HP:0003700)1.69829473
176Opisthotonus (HP:0002179)1.69661471
177Striae distensae (HP:0001065)1.68992102
178Elevated erythrocyte sedimentation rate (HP:0003565)1.66996570
179Interstitial pulmonary disease (HP:0006530)1.64579884
180Abnormality of the peritoneum (HP:0002585)1.64512899
181Premature loss of primary teeth (HP:0006323)1.63178493
182Bruising susceptibility (HP:0000978)1.62237477
183Difficulty running (HP:0009046)1.60339233
184Nuclear cataract (HP:0100018)1.60302036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.59326967
2BCKDK4.40381486
3MAP3K134.38473877
4TRIB33.97864041
5SIK13.75450870
6FGFR43.74215699
7PKN23.36506244
8PRPF4B2.43185689
9RIPK42.21377292
10PTK62.06988237
11MAP3K102.03418952
12TAOK32.01508103
13LATS12.00175242
14BLK1.90689014
15ARAF1.86087112
16TGFBR21.85044837
17EPHB11.77461063
18TYK21.70730930
19TTN1.68094318
20KDR1.64481379
21RIPK11.62868348
22MAP2K31.62787828
23FLT31.53620944
24MOS1.51177893
25MST1R1.50922412
26KSR21.48599910
27TIE11.46150476
28MYLK1.43875565
29FES1.42770558
30NEK91.40000857
31ERBB41.36777007
32TBK11.33512318
33MAPK111.28205036
34MAP3K11.26815505
35EEF2K1.26022010
36JAK11.23055007
37MAP4K11.20794236
38TESK11.19852287
39CDC42BPA1.19293525
40PRKD21.18344123
41PDGFRA1.16849206
42TAOK11.16564508
43IRAK41.16534116
44PIK3CG1.15495834
45MAP3K71.12955345
46INSRR1.12350715
47FGFR21.11805422
48LRRK21.11448878
49EPHA31.10267517
50MARK21.09828099
51CAMK1D1.08599090
52MAP3K31.04613092
53CDK61.00864723
54FGFR31.00323761
55STK380.98219328
56JAK20.97501231
57PTK20.96905913
58FGR0.95294715
59MAP3K60.93006848
60STK100.91349204
61BMPR20.90289441
62ILK0.90255569
63TAOK20.89491288
64SMG10.86075339
65PRKAA20.85289252
66BMX0.85116718
67ZAP700.85056778
68CSK0.84913526
69KSR10.84733070
70JAK30.84610107
71MTOR0.82875294
72ICK0.82838789
73MAP3K110.82122553
74GRK60.76205870
75MAP2K40.75728794
76BRAF0.74676632
77MET0.73692565
78RPS6KA20.72682175
79ABL20.71846821
80STK30.70895203
81MAPK120.68853036
82EPHA20.67371145
83FRK0.65453059
84STK38L0.64730356
85CSF1R0.64069136
86CDK40.63817599
87PAK40.63472870
88MAP3K140.63430624
89DYRK1B0.63221125
90KIT0.61807842
91IKBKE0.59312977
92TGFBR10.59147846
93ERBB20.59019654
94IKBKB0.58482763
95GSK3A0.58218482
96LYN0.58021573
97PDK10.57951506
98IRAK30.57574883
99CAMK1G0.57444847
100SIK30.56767255
101PTK2B0.54882521
102ITK0.54521930
103MAPK40.54419897
104RPS6KA40.54221354
105TNK20.53876992
106RET0.53291848
107SYK0.53004342
108PAK20.52839162
109RAF10.51335594
110DMPK0.49930843
111BTK0.49794589
112ROCK20.49695367
113LATS20.48994499
114DDR20.48518426
115HIPK20.48171677
116FGFR10.47765234
117PRKG20.47757040
118SGK30.47052970
119MAP3K20.46856849
120EPHB20.46347301
121RPS6KC10.46156046
122RPS6KL10.46156046
123CHUK0.46114010
124YES10.45416545
125CDK120.44483722
126PRKAA10.43642977
127PDGFRB0.43234736
128MAP2K20.42221072
129EGFR0.40437915
130FER0.39121006
131MAP2K10.38723991
132PDPK10.38081444
133MAPKAPK30.36290915
134IGF1R0.35975200
135PRKD10.35893011
136HCK0.33726626
137PRKACG0.33248894
138PRKCZ0.31951114
139MAPK70.30592067
140MAP2K60.28946199
141MAP3K50.28861758
142MAP3K80.28816317

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.20550795
2Nitrogen metabolism_Homo sapiens_hsa009103.47180176
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43111317
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.25672907
5Arginine biosynthesis_Homo sapiens_hsa002202.99784058
6Complement and coagulation cascades_Homo sapiens_hsa046102.80995175
7Fatty acid degradation_Homo sapiens_hsa000712.62770873
8Tryptophan metabolism_Homo sapiens_hsa003802.60139893
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56610181
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55092643
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39270212
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37600716
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20415087
14Osteoclast differentiation_Homo sapiens_hsa043802.14808191
15PPAR signaling pathway_Homo sapiens_hsa033202.05552740
16Staphylococcus aureus infection_Homo sapiens_hsa051501.98054638
17Propanoate metabolism_Homo sapiens_hsa006401.96542973
18Peroxisome_Homo sapiens_hsa041461.95885723
19Caffeine metabolism_Homo sapiens_hsa002321.94887916
20Other glycan degradation_Homo sapiens_hsa005111.93920228
21Fatty acid metabolism_Homo sapiens_hsa012121.91565843
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90917430
23Butanoate metabolism_Homo sapiens_hsa006501.90436966
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86844102
25Leishmaniasis_Homo sapiens_hsa051401.78935321
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77973746
27Chemical carcinogenesis_Homo sapiens_hsa052041.77726448
28Histidine metabolism_Homo sapiens_hsa003401.75926829
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.73262826
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72371766
31beta-Alanine metabolism_Homo sapiens_hsa004101.70454163
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67418872
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.60600155
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55893802
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.55405976
36Selenocompound metabolism_Homo sapiens_hsa004501.52877156
37B cell receptor signaling pathway_Homo sapiens_hsa046621.52790589
38Retinol metabolism_Homo sapiens_hsa008301.52063000
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50597672
40Bile secretion_Homo sapiens_hsa049761.46095141
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45308474
42Phenylalanine metabolism_Homo sapiens_hsa003601.41306973
43Chronic myeloid leukemia_Homo sapiens_hsa052201.37302252
44Tuberculosis_Homo sapiens_hsa051521.36855211
45Phagosome_Homo sapiens_hsa041451.33853471
46Starch and sucrose metabolism_Homo sapiens_hsa005001.33250393
47Pyruvate metabolism_Homo sapiens_hsa006201.32786317
48Platelet activation_Homo sapiens_hsa046111.31825541
49Pancreatic cancer_Homo sapiens_hsa052121.29593506
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28695664
51Fat digestion and absorption_Homo sapiens_hsa049751.27750011
52Tyrosine metabolism_Homo sapiens_hsa003501.24821728
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23850755
54Biosynthesis of amino acids_Homo sapiens_hsa012301.23029944
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22102237
56Renal cell carcinoma_Homo sapiens_hsa052111.20476044
57Carbon metabolism_Homo sapiens_hsa012001.20360417
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18646077
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.18414244
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18302155
61ABC transporters_Homo sapiens_hsa020101.16193097
62TNF signaling pathway_Homo sapiens_hsa046681.14293045
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13227841
64Folate biosynthesis_Homo sapiens_hsa007901.11437007
65Fatty acid elongation_Homo sapiens_hsa000621.11285300
66Viral myocarditis_Homo sapiens_hsa054161.10773598
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10544688
68Sulfur metabolism_Homo sapiens_hsa009201.08442269
69Chemokine signaling pathway_Homo sapiens_hsa040621.07365300
70Lysine degradation_Homo sapiens_hsa003101.06466076
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06221116
72Shigellosis_Homo sapiens_hsa051311.05821488
73VEGF signaling pathway_Homo sapiens_hsa043701.05607912
74Allograft rejection_Homo sapiens_hsa053301.02127821
75Autoimmune thyroid disease_Homo sapiens_hsa053200.99689277
76Sulfur relay system_Homo sapiens_hsa041220.98574216
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.98286798
78Non-small cell lung cancer_Homo sapiens_hsa052230.97205658
79Endocytosis_Homo sapiens_hsa041440.96805634
80Endometrial cancer_Homo sapiens_hsa052130.96529087
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.96449468
82Arginine and proline metabolism_Homo sapiens_hsa003300.96432361
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.94471346
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.92899412
85Graft-versus-host disease_Homo sapiens_hsa053320.92802316
86Steroid biosynthesis_Homo sapiens_hsa001000.92442397
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91241362
88Hematopoietic cell lineage_Homo sapiens_hsa046400.90877903
89Vitamin digestion and absorption_Homo sapiens_hsa049770.90294689
90Notch signaling pathway_Homo sapiens_hsa043300.89991257
91Influenza A_Homo sapiens_hsa051640.88295399
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86947569
93Salmonella infection_Homo sapiens_hsa051320.86440896
94T cell receptor signaling pathway_Homo sapiens_hsa046600.86163217
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85704262
96Apoptosis_Homo sapiens_hsa042100.85051070
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.83094318
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82549232
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80949796
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.80582753
101Hepatitis B_Homo sapiens_hsa051610.79421757
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79246631
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78324466
104Antigen processing and presentation_Homo sapiens_hsa046120.75303836
105Measles_Homo sapiens_hsa051620.75084355
106Glycerolipid metabolism_Homo sapiens_hsa005610.74204437
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72738591
108GnRH signaling pathway_Homo sapiens_hsa049120.72324852
109Thyroid cancer_Homo sapiens_hsa052160.72319633
110Prolactin signaling pathway_Homo sapiens_hsa049170.72273046
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72150665
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.71988905
113Choline metabolism in cancer_Homo sapiens_hsa052310.71578231
114Rheumatoid arthritis_Homo sapiens_hsa053230.70322774
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66911373
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66379522
117Rap1 signaling pathway_Homo sapiens_hsa040150.65315912
118Pentose phosphate pathway_Homo sapiens_hsa000300.64258019
119Glutathione metabolism_Homo sapiens_hsa004800.63412386
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63273724
121Vitamin B6 metabolism_Homo sapiens_hsa007500.63253910
122Glioma_Homo sapiens_hsa052140.61150358
123Prostate cancer_Homo sapiens_hsa052150.60892572
124Fatty acid biosynthesis_Homo sapiens_hsa000610.60424661
125One carbon pool by folate_Homo sapiens_hsa006700.60111474
126Dilated cardiomyopathy_Homo sapiens_hsa054140.58993262
127Adherens junction_Homo sapiens_hsa045200.58471072
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57980114
129Insulin resistance_Homo sapiens_hsa049310.57892217
130FoxO signaling pathway_Homo sapiens_hsa040680.57781432
131Sphingolipid metabolism_Homo sapiens_hsa006000.57547716
132Dorso-ventral axis formation_Homo sapiens_hsa043200.57207623
133mTOR signaling pathway_Homo sapiens_hsa041500.56796816
134HIF-1 signaling pathway_Homo sapiens_hsa040660.56500546
135Colorectal cancer_Homo sapiens_hsa052100.53078355
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53001127
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.51710227
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51061495
139Estrogen signaling pathway_Homo sapiens_hsa049150.50590087
140ErbB signaling pathway_Homo sapiens_hsa040120.50372203
141Inositol phosphate metabolism_Homo sapiens_hsa005620.50125034
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.49809327
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49049845
144Pathways in cancer_Homo sapiens_hsa052000.48387769
145Ras signaling pathway_Homo sapiens_hsa040140.46056066
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36826231
147Galactose metabolism_Homo sapiens_hsa000520.32910116
148Metabolic pathways_Homo sapiens_hsa011000.31075281
149Prion diseases_Homo sapiens_hsa050200.29108467
150Fructose and mannose metabolism_Homo sapiens_hsa000510.26109575
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22938284
152AMPK signaling pathway_Homo sapiens_hsa041520.22249637
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.19035028
154Glucagon signaling pathway_Homo sapiens_hsa049220.14156358
155Linoleic acid metabolism_Homo sapiens_hsa005910.10384441
156Amoebiasis_Homo sapiens_hsa051460.09093052
157Insulin signaling pathway_Homo sapiens_hsa049100.07944280
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.07851492
159Bladder cancer_Homo sapiens_hsa052190.06397315
160Central carbon metabolism in cancer_Homo sapiens_hsa052300.05976081
161Hepatitis C_Homo sapiens_hsa051600.01019454
162Lysosome_Homo sapiens_hsa041420.00274339
163Proteoglycans in cancer_Homo sapiens_hsa05205-0.0829312
164Toxoplasmosis_Homo sapiens_hsa05145-0.0787959
165Focal adhesion_Homo sapiens_hsa04510-0.0755828
166Legionellosis_Homo sapiens_hsa05134-0.0709566
167Protein digestion and absorption_Homo sapiens_hsa04974-0.0699829
168Pertussis_Homo sapiens_hsa05133-0.0578193
169Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0517910
170Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0502883
171Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0429647
172Small cell lung cancer_Homo sapiens_hsa05222-0.0360388
173Acute myeloid leukemia_Homo sapiens_hsa05221-0.0347924
174Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0345588
175Malaria_Homo sapiens_hsa05144-0.0267081
176ECM-receptor interaction_Homo sapiens_hsa04512-0.0204997
177Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0135686

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