WBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.52781906
2synaptic vesicle exocytosis (GO:0016079)5.36738035
3glutamate secretion (GO:0014047)5.16401954
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.14154244
5regulation of synaptic vesicle exocytosis (GO:2000300)5.04095363
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.73742924
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62995137
8locomotory exploration behavior (GO:0035641)4.58746377
9regulation of synaptic vesicle transport (GO:1902803)4.48997324
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.40354009
11neuronal action potential propagation (GO:0019227)4.33172534
12vocalization behavior (GO:0071625)4.28843477
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17073280
14neurotransmitter secretion (GO:0007269)4.13110803
15regulation of glutamate receptor signaling pathway (GO:1900449)3.95533223
16protein localization to synapse (GO:0035418)3.81611546
17neuromuscular process controlling posture (GO:0050884)3.81375982
18regulation of neuronal synaptic plasticity (GO:0048168)3.74245295
19neuron cell-cell adhesion (GO:0007158)3.74041851
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69588318
21negative regulation of cell killing (GO:0031342)3.69588318
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66320940
23neurotransmitter-gated ion channel clustering (GO:0072578)3.58972828
24cellular potassium ion homeostasis (GO:0030007)3.57953781
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.54907421
26regulation of ARF protein signal transduction (GO:0032012)3.53896405
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51169536
28neurotransmitter transport (GO:0006836)3.46316177
29gamma-aminobutyric acid transport (GO:0015812)3.45800454
30exploration behavior (GO:0035640)3.43953665
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43404233
32synaptic transmission, glutamatergic (GO:0035249)3.39029694
33neuron-neuron synaptic transmission (GO:0007270)3.33794023
34sodium ion export (GO:0071436)3.33574149
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32188660
36long-term synaptic potentiation (GO:0060291)3.30462495
37regulation of synapse structural plasticity (GO:0051823)3.29008932
38glycine transport (GO:0015816)3.28164697
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.27622922
40transferrin transport (GO:0033572)3.25452737
41regulation of neurotransmitter levels (GO:0001505)3.22468261
42negative regulation of erythrocyte differentiation (GO:0045647)3.22082358
43positive regulation of membrane potential (GO:0045838)3.20924749
44regulation of neurotransmitter secretion (GO:0046928)3.20281502
45adenosine receptor signaling pathway (GO:0001973)3.20205169
46energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.18774987
47ATP hydrolysis coupled proton transport (GO:0015991)3.18774987
48acidic amino acid transport (GO:0015800)3.18429243
49signal complex assembly (GO:0007172)3.17130713
50L-glutamate transport (GO:0015813)3.14360768
51glutamate receptor signaling pathway (GO:0007215)3.14286373
52regulation of synaptic plasticity (GO:0048167)3.13847843
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13149031
54neutrophil activation involved in immune response (GO:0002283)3.12237839
55amino acid import (GO:0043090)3.10996556
56activation of protein kinase A activity (GO:0034199)3.08771584
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07783921
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07297435
59cerebellar granule cell differentiation (GO:0021707)3.05133293
60long-term memory (GO:0007616)3.03416927
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03334090
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02935591
63ferric iron transport (GO:0015682)3.02708989
64trivalent inorganic cation transport (GO:0072512)3.02708989
65gamma-aminobutyric acid signaling pathway (GO:0007214)2.99640694
66regulation of neurotransmitter transport (GO:0051588)2.98982174
67regulation of vesicle fusion (GO:0031338)2.98353458
68regulation of T-helper 2 cell differentiation (GO:0045628)2.97666748
69synaptic vesicle endocytosis (GO:0048488)2.96914138
70positive regulation of synapse maturation (GO:0090129)2.96667301
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96591627
72regulation of synaptic transmission, glutamatergic (GO:0051966)2.96587357
73proline transport (GO:0015824)2.95918021
74regulation of voltage-gated calcium channel activity (GO:1901385)2.94173675
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90422075
76regulation of postsynaptic membrane potential (GO:0060078)2.89687522
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88360991
78negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87890071
79positive regulation of neurotransmitter transport (GO:0051590)2.85128584
80neuromuscular process controlling balance (GO:0050885)2.83912271
81cerebellar Purkinje cell differentiation (GO:0021702)2.81754721
82adult walking behavior (GO:0007628)2.80664757
83positive regulation of synaptic transmission (GO:0050806)2.79303418
84regulation of glutamate secretion (GO:0014048)2.77766245
85membrane depolarization during action potential (GO:0086010)2.77737753
86transmission of nerve impulse (GO:0019226)2.76691975
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75441490
88regulation of synaptic transmission (GO:0050804)2.74938762
89layer formation in cerebral cortex (GO:0021819)2.74363496
90cell communication by electrical coupling (GO:0010644)2.73592365
91membrane hyperpolarization (GO:0060081)2.73255638
92positive regulation of Rap GTPase activity (GO:0032854)2.72822539
93negative regulation of microtubule polymerization (GO:0031115)2.71136556
94postsynaptic membrane organization (GO:0001941)2.70972473
95synaptic transmission (GO:0007268)2.70561817
96establishment of synaptic vesicle localization (GO:0097480)2.70452790
97synaptic vesicle transport (GO:0048489)2.70452790
98L-amino acid import (GO:0043092)2.70154934
99regulation of regulated secretory pathway (GO:1903305)2.69425628
100positive regulation of neurotransmitter secretion (GO:0001956)2.69066034
101potassium ion import (GO:0010107)2.66410655
102calcium ion-dependent exocytosis (GO:0017156)2.65572497
103membrane depolarization (GO:0051899)2.65283089
104regulation of amyloid precursor protein catabolic process (GO:1902991)2.65244690
105response to auditory stimulus (GO:0010996)2.64454384
106positive regulation of cellular amide metabolic process (GO:0034250)2.63260510
107antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62489086
108presynaptic membrane organization (GO:0097090)2.61985298
109protein localization to endosome (GO:0036010)2.61440567
110neurotransmitter uptake (GO:0001504)2.60755750
111dicarboxylic acid transport (GO:0006835)2.59299042
112neuromuscular process (GO:0050905)2.59100588
113vesicle transport along microtubule (GO:0047496)2.58508193
114potassium ion homeostasis (GO:0055075)2.57932987
115cytoskeletal anchoring at plasma membrane (GO:0007016)2.56560760
116negative regulation of amino acid transport (GO:0051956)2.56556389
117regulation of early endosome to late endosome transport (GO:2000641)2.56106120
118macrophage activation involved in immune response (GO:0002281)2.54051226
119G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.52980564
120regulation of myeloid leukocyte mediated immunity (GO:0002886)2.51679131
121regulation of mast cell degranulation (GO:0043304)2.50823492
122regulation of leukocyte degranulation (GO:0043300)2.50171970
123neuronal ion channel clustering (GO:0045161)2.47184902
124positive regulation of protein dephosphorylation (GO:0035307)2.45991852
125modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42992984
126positive regulation by organism of defense response of other organism involved in symbiotic interact2.42992984
127modulation by symbiont of host immune response (GO:0052553)2.42992984
128positive regulation by symbiont of host defense response (GO:0052509)2.42992984
129modulation by symbiont of host defense response (GO:0052031)2.42992984
130modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42992984
131antigen processing and presentation of endogenous antigen (GO:0019883)2.42399754
132actin filament polymerization (GO:0030041)2.41278954
133peptidyl-tyrosine autophosphorylation (GO:0038083)2.39725547
134regulation of platelet aggregation (GO:0090330)2.39497294
135negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.37512096
136positive regulation of gamma-delta T cell activation (GO:0046645)2.32753140
137regulation of Rap GTPase activity (GO:0032317)2.29845049
138regulation of ARF GTPase activity (GO:0032312)2.29597553
139positive regulation of receptor recycling (GO:0001921)2.27233407
140regulation of beta-amyloid formation (GO:1902003)2.26889841
141regulation of female receptivity (GO:0045924)2.25244223
142neutrophil activation (GO:0042119)2.24043289
143negative regulation of leukocyte mediated immunity (GO:0002704)2.23800231
144central nervous system myelination (GO:0022010)2.23775902
145axon ensheathment in central nervous system (GO:0032291)2.23775902
146granulocyte activation (GO:0036230)2.23246837
147myelin maintenance (GO:0043217)2.22679908
148antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.21452316
149positive regulation of mast cell activation (GO:0033005)2.21138921
150leukocyte migration involved in inflammatory response (GO:0002523)2.20872281
151protein targeting to plasma membrane (GO:0072661)2.20864405
152regulation of mast cell activation involved in immune response (GO:0033006)2.19619808
153positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.19581676
154germinal center formation (GO:0002467)2.19238509
155detection of other organism (GO:0098543)2.19129014
156barbed-end actin filament capping (GO:0051016)2.18247786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.70117188
2GBX2_23144817_ChIP-Seq_PC3_Human3.03913292
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01247247
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89676207
5REST_21632747_ChIP-Seq_MESCs_Mouse2.73773013
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.67522907
7SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60766923
8REST_18959480_ChIP-ChIP_MESCs_Mouse2.54215144
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52322513
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52188527
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49783430
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45544096
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45544096
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.45135398
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.45115303
16DROSHA_22980978_ChIP-Seq_HELA_Human2.44242456
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39802749
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.39291748
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37959386
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29501508
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27026654
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.21949825
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.08515756
24KDM2B_26808549_Chip-Seq_DND41_Human1.99940927
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95596720
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.92467432
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91840019
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.90357815
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90072072
30TCF7_22412390_ChIP-Seq_EML_Mouse1.83955631
31* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83891336
32VDR_21846776_ChIP-Seq_THP-1_Human1.82488224
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.81851132
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.80555461
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78064091
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.77994815
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75746333
38* GATA1_19941827_ChIP-Seq_MEL_Mouse1.75542259
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70772513
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.70620953
41* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68602184
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65318127
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62948303
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61105738
45GATA1_19941826_ChIP-Seq_K562_Human1.59467723
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58732969
47* SPI1_23127762_ChIP-Seq_K562_Human1.56885315
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56831712
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54233149
50* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52541879
51RACK7_27058665_Chip-Seq_MCF-7_Human1.50610444
52* P68_20966046_ChIP-Seq_HELA_Human1.50286282
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47660300
54VDR_24763502_ChIP-Seq_THP-1_Human1.47234834
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46784400
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.44669946
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.42497344
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.40032076
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35443115
60SCL_19346495_ChIP-Seq_HPC-7_Human1.35060629
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.35015025
62* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33762205
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33609808
64* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32406213
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31362412
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31037420
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29524092
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27161210
69* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26675051
70* BCOR_27268052_Chip-Seq_Bcells_Human1.26209704
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.26137259
72* ELF1_20517297_ChIP-Seq_JURKAT_Human1.24016871
73AR_21572438_ChIP-Seq_LNCaP_Human1.23286901
74MAF_26560356_Chip-Seq_TH1_Human1.23233070
75SMAD4_21799915_ChIP-Seq_A2780_Human1.23211754
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23172055
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22666959
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21108199
79* BCL6_27268052_Chip-Seq_Bcells_Human1.19784571
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19739109
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.19628771
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19323489
83CREB1_26743006_Chip-Seq_LNCaP_Human1.19112156
84* MYC_22102868_ChIP-Seq_BL_Human1.19050549
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18418617
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18180610
87* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17918767
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17876790
89* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17831085
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17344124
91UTX_26944678_Chip-Seq_JUKART_Human1.17132928
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16342953
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15976951
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.15169036
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13741404
96* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12716562
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11686452
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.11588333
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.10823682
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09273537
101CTCF_27219007_Chip-Seq_Bcells_Human1.08780065
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.07979282
103KDM2B_26808549_Chip-Seq_K562_Human1.07892474
104* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07341255
105SA1_27219007_Chip-Seq_Bcells_Human1.07303727
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06944695
107OCT4_19829295_ChIP-Seq_ESCs_Human1.06594081
108MAF_26560356_Chip-Seq_TH2_Human1.06503548
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05374333
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05008226
111TAF15_26573619_Chip-Seq_HEK293_Human1.04989911
112* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04414834
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03798591
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03486275
115TET1_21490601_ChIP-Seq_MESCs_Mouse1.02518978
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02201835
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01914946
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01594176
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00948113
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00305233
121GATA2_19941826_ChIP-Seq_K562_Human0.99767341
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98473620
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98285573
124P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97193401
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96495642
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96070723
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95834719
128AR_25329375_ChIP-Seq_VCAP_Human0.95075696
129AR_19668381_ChIP-Seq_PC3_Human0.94093588
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93148832
131P300_19829295_ChIP-Seq_ESCs_Human0.91952904
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91155170
133LXR_22292898_ChIP-Seq_THP-1_Human0.90539834
134SMC4_20622854_ChIP-Seq_HELA_Human0.89384344
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88219223
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.87564958
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86801406
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85755266
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.84953409
140CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84617630
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84486538
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84230000
143RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83490818
144VDR_22108803_ChIP-Seq_LS180_Human0.82879063
145ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82527420
146STAT3_23295773_ChIP-Seq_U87_Human0.82494059
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82219836
148* SMAD3_21741376_ChIP-Seq_ESCs_Human0.80454695
149* PRDM14_20953172_ChIP-Seq_ESCs_Human0.78274732
150CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78217762
151SMAD4_21741376_ChIP-Seq_EPCs_Human0.77974043
152KLF4_19829295_ChIP-Seq_ESCs_Human0.77968754
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76602366
154AHR_22903824_ChIP-Seq_MCF-7_Human0.76521527
155WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76130341
156RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.75985327
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.75629148
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.75223370
159RING1B_27294783_Chip-Seq_NPCs_Mouse0.74996583
160TCF4_23295773_ChIP-Seq_U87_Human0.74485317
161ZNF274_21170338_ChIP-Seq_K562_Hela0.74161952
162TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.74080685
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.73240422
164ESR2_21235772_ChIP-Seq_MCF-7_Human0.73022601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.43272579
2MP0003880_abnormal_central_pattern4.25241318
3MP0003635_abnormal_synaptic_transmissio3.69924454
4MP0004270_analgesia3.40677889
5MP0002064_seizures3.25335643
6MP0009046_muscle_twitch3.14207752
7MP0009745_abnormal_behavioral_response3.09947490
8MP0001968_abnormal_touch/_nociception3.02668596
9MP0003303_peritoneal_inflammation3.00061183
10MP0002063_abnormal_learning/memory/cond2.86680373
11MP0002272_abnormal_nervous_system2.75441139
12MP0002736_abnormal_nociception_after2.64170376
13MP0003436_decreased_susceptibility_to2.62322448
14MP0005423_abnormal_somatic_nervous2.53649953
15MP0002572_abnormal_emotion/affect_behav2.52072790
16MP0002734_abnormal_mechanical_nocicepti2.51040287
17MP0005464_abnormal_platelet_physiology2.50017616
18MP0002735_abnormal_chemical_nociception2.47007581
19MP0003724_increased_susceptibility_to2.46124784
20MP0002822_catalepsy2.40287853
21MP0003329_amyloid_beta_deposits2.32937569
22MP0001486_abnormal_startle_reflex2.23394693
23MP0001501_abnormal_sleep_pattern2.18528204
24MP0002733_abnormal_thermal_nociception2.10195594
25MP0004858_abnormal_nervous_system2.08148475
26MP0001970_abnormal_pain_threshold2.05698438
27MP0008260_abnormal_autophagy2.02761295
28MP0008569_lethality_at_weaning2.01116891
29MP0002067_abnormal_sensory_capabilities1.94430172
30MP0001440_abnormal_grooming_behavior1.90418805
31MP0003191_abnormal_cellular_cholesterol1.89351556
32MP0002909_abnormal_adrenal_gland1.87760094
33MP0005646_abnormal_pituitary_gland1.78452371
34MP0009780_abnormal_chondrocyte_physiolo1.78127571
35MP0009840_abnormal_foam_cell1.74496271
36MP0003879_abnormal_hair_cell1.71930233
37MP0004142_abnormal_muscle_tone1.64838859
38MP0001984_abnormal_olfaction1.58132642
39MP0002419_abnormal_innate_immunity1.58015200
40MP0006276_abnormal_autonomic_nervous1.57607266
41MP0006082_CNS_inflammation1.55132525
42MP0003633_abnormal_nervous_system1.54900839
43MP0005000_abnormal_immune_tolerance1.54757896
44MP0003300_gastrointestinal_ulcer1.53218698
45MP0004811_abnormal_neuron_physiology1.52758422
46MP0005386_behavior/neurological_phenoty1.52596485
47MP0004924_abnormal_behavior1.52596485
48MP0004043_abnormal_pH_regulation1.51201806
49MP0001905_abnormal_dopamine_level1.51138749
50MP0000920_abnormal_myelination1.49953319
51MP0004885_abnormal_endolymph1.49321771
52MP0005025_abnormal_response_to1.48296155
53MP0002557_abnormal_social/conspecific_i1.47338214
54MP0002184_abnormal_innervation1.45107458
55MP0001502_abnormal_circadian_rhythm1.43122479
56MP0002066_abnormal_motor_capabilities/c1.39200268
57MP0000955_abnormal_spinal_cord1.38890495
58MP0001533_abnormal_skeleton_physiology1.37300200
59MP0003690_abnormal_glial_cell1.37238327
60MP0000013_abnormal_adipose_tissue1.37004538
61MP0001529_abnormal_vocalization1.34935162
62MP0001986_abnormal_taste_sensitivity1.33758635
63MP0002229_neurodegeneration1.33489794
64MP0009278_abnormal_bone_marrow1.32729984
65MP0002148_abnormal_hypersensitivity_rea1.32338158
66MP0002837_dystrophic_cardiac_calcinosis1.32316723
67MP0005166_decreased_susceptibility_to1.31582876
68MP0002882_abnormal_neuron_morphology1.31348394
69MP0000343_altered_response_to1.31157506
70MP0004947_skin_inflammation1.31090814
71MP0003631_nervous_system_phenotype1.29481536
72MP0005671_abnormal_response_to1.29399028
73MP0001790_abnormal_immune_system1.26828558
74MP0005387_immune_system_phenotype1.26828558
75MP0004130_abnormal_muscle_cell1.23957435
76MP0003634_abnormal_glial_cell1.23922930
77MP0008004_abnormal_stomach_pH1.21769069
78MP0000604_amyloidosis1.21395546
79MP0005645_abnormal_hypothalamus_physiol1.21014520
80MP0005551_abnormal_eye_electrophysiolog1.20607423
81MP0008872_abnormal_physiological_respon1.19243938
82MP0001835_abnormal_antigen_presentation1.17987628
83MP0003183_abnormal_peptide_metabolism1.17616305
84MP0009785_altered_susceptibility_to1.16609649
85MP0000778_abnormal_nervous_system1.14972229
86MP0002723_abnormal_immune_serum1.14041203
87MP0005451_abnormal_body_composition1.13231069
88MP0003075_altered_response_to1.12939451
89MP0005535_abnormal_body_temperature1.07989996
90MP0000685_abnormal_immune_system1.07309337
91MP0002420_abnormal_adaptive_immunity1.05463167
92MP0000751_myopathy1.04788588
93MP0001819_abnormal_immune_cell1.03956693
94MP0001800_abnormal_humoral_immune1.00260792
95MP0003122_maternal_imprinting1.00212894
96MP0002452_abnormal_antigen_presenting0.97553865
97MP0002090_abnormal_vision0.97159336
98MP0008874_decreased_physiological_sensi0.95380997
99MP0004742_abnormal_vestibular_system0.95163029
100MP0002653_abnormal_ependyma_morphology0.95150918
101MP0001851_eye_inflammation0.94607042
102MP0002998_abnormal_bone_remodeling0.94414293
103MP0003172_abnormal_lysosome_physiology0.93764465
104MP0002069_abnormal_eating/drinking_beha0.92642645
105MP0003632_abnormal_nervous_system0.91694042
106MP0003866_abnormal_defecation0.90855422
107MP0010386_abnormal_urinary_bladder0.87591736
108MP0010155_abnormal_intestine_physiology0.87198584
109MP0003045_fibrosis0.87136283
110MP0002876_abnormal_thyroid_physiology0.85693711
111MP0001348_abnormal_lacrimal_gland0.85343484
112MP0001963_abnormal_hearing_physiology0.84102725
113MP0004145_abnormal_muscle_electrophysio0.81281993
114MP0004085_abnormal_heartbeat0.81034391
115MP0001765_abnormal_ion_homeostasis0.80936503
116MP0005397_hematopoietic_system_phenotyp0.79969943
117MP0001545_abnormal_hematopoietic_system0.79969943
118MP0001845_abnormal_inflammatory_respons0.79626917
119MP0002152_abnormal_brain_morphology0.79341387
120MP0005058_abnormal_lysosome_morphology0.79226342
121MP0003787_abnormal_imprinting0.79135564
122MP0005409_darkened_coat_color0.78966569
123MP0005083_abnormal_biliary_tract0.78536042
124MP0000858_altered_metastatic_potential0.78118591
125MP0003656_abnormal_erythrocyte_physiolo0.75780543
126MP0003828_pulmonary_edema0.74434742
127MP0009764_decreased_sensitivity_to0.73829730
128MP0003195_calcinosis0.72834012
129MP0000465_gastrointestinal_hemorrhage0.72047666
130MP0000716_abnormal_immune_system0.71634538
131MP0002398_abnormal_bone_marrow0.71300694
132MP0002752_abnormal_somatic_nervous0.71282116
133MP0004147_increased_porphyrin_level0.70851758
134MP0001664_abnormal_digestion0.68908625
135MP0005165_increased_susceptibility_to0.68867677
136MP0008961_abnormal_basal_metabolism0.68075241
137MP0003705_abnormal_hypodermis_morpholog0.67319546
138MP0004036_abnormal_muscle_relaxation0.66331932
139MP0003638_abnormal_response/metabolism_0.65146719
140MP0005167_abnormal_blood-brain_barrier0.63449915
141MP0000749_muscle_degeneration0.63125757
142MP0001485_abnormal_pinna_reflex0.62980439
143MP0000747_muscle_weakness0.60720747
144MP0005410_abnormal_fertilization0.60249714
145MP0004510_myositis0.59923514
146MP0005394_taste/olfaction_phenotype0.58736759
147MP0005499_abnormal_olfactory_system0.58736759
148MP0000639_abnormal_adrenal_gland0.58690356
149MP0005584_abnormal_enzyme/coenzyme_acti0.58333193
150MP0005253_abnormal_eye_physiology0.57966717
151MP0004215_abnormal_myocardial_fiber0.57399093
152MP0003646_muscle_fatigue0.57366388

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.22262916
2Focal motor seizures (HP:0011153)5.88730936
3Focal seizures (HP:0007359)4.55247232
4Epileptic encephalopathy (HP:0200134)4.45878682
5Atonic seizures (HP:0010819)4.44797770
6Visual hallucinations (HP:0002367)4.44515044
7Supranuclear gaze palsy (HP:0000605)3.92771473
8Febrile seizures (HP:0002373)3.79658421
9Pheochromocytoma (HP:0002666)3.67699073
10Progressive cerebellar ataxia (HP:0002073)3.64024856
11Purpura (HP:0000979)3.55121019
12Action tremor (HP:0002345)3.44864707
13Absence seizures (HP:0002121)3.38920575
14Neurofibrillary tangles (HP:0002185)3.35078171
15Ankle clonus (HP:0011448)3.34605857
16Generalized tonic-clonic seizures (HP:0002069)3.33969376
17Prolonged bleeding time (HP:0003010)3.33643851
18Eczematoid dermatitis (HP:0000976)3.31919694
19Obstructive sleep apnea (HP:0002870)3.31669335
20Neuroendocrine neoplasm (HP:0100634)3.28661107
21Abnormal eating behavior (HP:0100738)3.27536480
22Dialeptic seizures (HP:0011146)3.21890803
23Abnormality of macrophages (HP:0004311)3.18015001
24Depression (HP:0000716)3.17197835
25Anxiety (HP:0000739)3.11951786
26Petechiae (HP:0000967)2.95530129
27Dysmetria (HP:0001310)2.94769715
28Cerebral inclusion bodies (HP:0100314)2.85377249
29Postural instability (HP:0002172)2.78684628
30Dysdiadochokinesis (HP:0002075)2.78095881
31Hyperventilation (HP:0002883)2.76708657
32Dysostosis multiplex (HP:0000943)2.76291524
33Scanning speech (HP:0002168)2.70712310
34Poor eye contact (HP:0000817)2.68525620
35Truncal ataxia (HP:0002078)2.61439437
36Abnormality of liposaccharide metabolism (HP:0010968)2.61416826
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.61416826
38Abnormality of glycolipid metabolism (HP:0010969)2.61416826
39Papilledema (HP:0001085)2.60983238
40Myositis (HP:0100614)2.58606961
41Torticollis (HP:0000473)2.58202481
42Abnormal social behavior (HP:0012433)2.57185708
43Impaired social interactions (HP:0000735)2.57185708
44Abnormality of the lower motor neuron (HP:0002366)2.54251198
45Epistaxis (HP:0000421)2.54029317
46Polyphagia (HP:0002591)2.52152366
47Orchitis (HP:0100796)2.52138236
48Menorrhagia (HP:0000132)2.51263415
49Tetraplegia (HP:0002445)2.50272653
50Cholecystitis (HP:0001082)2.49937354
51Abnormal gallbladder physiology (HP:0012438)2.49937354
52Apathy (HP:0000741)2.49380426
53Focal dystonia (HP:0004373)2.48350772
54Spastic gait (HP:0002064)2.48306527
55Impaired vibration sensation in the lower limbs (HP:0002166)2.44875116
56Axonal loss (HP:0003447)2.44389323
57Recurrent abscess formation (HP:0002722)2.42588565
58Amyloidosis (HP:0011034)2.42334201
59Gaze-evoked nystagmus (HP:0000640)2.41351559
60Intention tremor (HP:0002080)2.41092134
61Failure to thrive in infancy (HP:0001531)2.39192165
62Systemic lupus erythematosus (HP:0002725)2.39188931
63Diminished motivation (HP:0000745)2.37886085
64Limb dystonia (HP:0002451)2.37756029
65Diplopia (HP:0000651)2.36351997
66Abnormality of binocular vision (HP:0011514)2.36351997
67Loss of speech (HP:0002371)2.36143033
68Slow saccadic eye movements (HP:0000514)2.33964082
69Recurrent bacterial skin infections (HP:0005406)2.33391460
70Progressive inability to walk (HP:0002505)2.32493790
71Gingival bleeding (HP:0000225)2.31641371
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.30881618
73Psychosis (HP:0000709)2.29513234
74Craniofacial dystonia (HP:0012179)2.29486390
75Increased circulating renin level (HP:0000848)2.29478920
76Urinary bladder sphincter dysfunction (HP:0002839)2.28132879
77Ventricular fibrillation (HP:0001663)2.26812016
78Epileptiform EEG discharges (HP:0011182)2.26471251
79Spontaneous hematomas (HP:0007420)2.25201290
80Bradykinesia (HP:0002067)2.24831379
81Recurrent gram-negative bacterial infections (HP:0005420)2.24626231
82Hemiparesis (HP:0001269)2.23323386
83Chronic obstructive pulmonary disease (HP:0006510)2.22839109
84Obstructive lung disease (HP:0006536)2.22839109
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.22132159
86Delusions (HP:0000746)2.21096116
87Broad-based gait (HP:0002136)2.19217613
88Abnormal platelet volume (HP:0011876)2.19147403
89Status epilepticus (HP:0002133)2.18649045
90Optic neuritis (HP:0100653)2.17780472
91Retrobulbar optic neuritis (HP:0100654)2.17780472
92EEG with generalized epileptiform discharges (HP:0011198)2.16308921
93Urinary urgency (HP:0000012)2.16290287
94Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15839834
95Rigidity (HP:0002063)2.14764341
96Neuronal loss in central nervous system (HP:0002529)2.12870843
97Amblyopia (HP:0000646)2.12135240
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09476537
99Hypsarrhythmia (HP:0002521)2.09365746
100Retinal dysplasia (HP:0007973)2.09058661
101Abnormality of the corticospinal tract (HP:0002492)2.08838302
102Dementia (HP:0000726)2.08255337
103Episodic fever (HP:0001954)2.06707702
104Dysmetric saccades (HP:0000641)2.06533850
105Agitation (HP:0000713)2.04726840
106Mutism (HP:0002300)2.04387141
107Increased IgE level (HP:0003212)2.02592272
108Abnormality of saccadic eye movements (HP:0000570)2.01907801
109Peripheral hypomyelination (HP:0007182)2.01182673
110Generalized myoclonic seizures (HP:0002123)2.00756885
111Cellulitis (HP:0100658)1.99368754
112Neoplasm of the peripheral nervous system (HP:0100007)1.98914361
113Termporal pattern (HP:0011008)1.96926597
114Insidious onset (HP:0003587)1.96926597
115Abnormality of polysaccharide metabolism (HP:0011012)1.95769973
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95769973
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95769973
118Lower limb muscle weakness (HP:0007340)1.94128657
119Hypercortisolism (HP:0001578)1.93855452
120Genetic anticipation (HP:0003743)1.93044153
121Increased cerebral lipofuscin (HP:0011813)1.91894631
122Mediastinal lymphadenopathy (HP:0100721)1.91838621
123Impaired smooth pursuit (HP:0007772)1.90226312
124Memory impairment (HP:0002354)1.90068049
125Abnormality of the heme biosynthetic pathway (HP:0010472)1.89584677
126Gout (HP:0001997)1.89578747
127Stomatitis (HP:0010280)1.89481568
128Megalencephaly (HP:0001355)1.89143696
129Postural tremor (HP:0002174)1.89111408
130Resting tremor (HP:0002322)1.87403024
131Polycythemia (HP:0001901)1.87066448
132Clonus (HP:0002169)1.86857636
133Rapidly progressive (HP:0003678)1.86152233
134Lower limb amyotrophy (HP:0007210)1.86100323
135Mucopolysacchariduria (HP:0008155)1.85852255
136Urinary glycosaminoglycan excretion (HP:0003541)1.85852255
137Central scotoma (HP:0000603)1.85220419
138Gait ataxia (HP:0002066)1.84601665
139Poor suck (HP:0002033)1.84350980
140Distal upper limb amyotrophy (HP:0007149)1.84348852
141Upper limb amyotrophy (HP:0009129)1.84348852
142Impaired vibratory sensation (HP:0002495)1.84096203
143Increased mean platelet volume (HP:0011877)1.83907809
144Hemiplegia (HP:0002301)1.83551099
145Decreased motor nerve conduction velocity (HP:0003431)1.83442700
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81142394
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.81142394
148Growth hormone excess (HP:0000845)1.80967076
149Cerebral hypomyelination (HP:0006808)1.80060728
150Inability to walk (HP:0002540)1.79785453
151Vertigo (HP:0002321)1.79531022
152Nuclear cataract (HP:0100018)1.78557564
153Foot dorsiflexor weakness (HP:0009027)1.78509474
154Clumsiness (HP:0002312)1.78251597
155Hepatosplenomegaly (HP:0001433)1.77716608
156Bundle branch block (HP:0011710)1.77481141
157Annular pancreas (HP:0001734)1.75797107
158Onion bulb formation (HP:0003383)1.75567614
159Stereotypic behavior (HP:0000733)1.74701673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.56384288
2MAP3K93.33419956
3EPHA43.26958171
4DAPK22.80345619
5MAP3K122.79992099
6CASK2.47731728
7ERN12.37404813
8MAP3K42.36263978
9MINK12.35201757
10KSR22.24057869
11ARAF2.21241787
12MAP2K72.15270096
13CDK192.12042505
14PRKD32.09967980
15PAK62.07764170
16RIPK11.95921585
17PRPF4B1.93625389
18NTRK11.83727951
19OXSR11.83502600
20GRK51.77593421
21TRIB31.72453310
22MAP2K41.67479967
23DAPK11.65286263
24TAOK21.62800940
25UHMK11.59922970
26MARK11.52716778
27MAP2K31.50290680
28NTRK21.49605371
29SGK4941.44265026
30SGK2231.44265026
31CAMKK11.42986881
32CDK51.42407763
33WNK41.42324398
34TESK11.39503290
35RIPK41.36562915
36MAP3K21.31835903
37MAP4K11.30162204
38PINK11.29503667
39MAP3K31.24639564
40STK391.21582110
41SIK11.21413221
42GRK61.21161694
43CAMKK21.18221172
44TESK21.16243514
45PHKG11.14216398
46PHKG21.14216398
47LMTK21.13946192
48PRKCG1.13361249
49MAP3K131.12929772
50PLK21.12868852
51MAPK121.12742007
52ZAP701.12424643
53STK381.09588304
54BLK1.09059189
55ICK1.08560937
56BMX1.08297904
57PTK2B1.07404583
58PRKCH1.02930269
59MAP3K11.01263881
60FES1.00248487
61WNK30.99510793
62MAPKAPK50.98489433
63CAMK2B0.97652059
64CAMK2A0.97174091
65TNIK0.95252522
66SIK30.95188063
67IRAK30.94569597
68TYK20.93580435
69CSK0.93010780
70CDK140.92519465
71CDK180.92189238
72TBK10.91780284
73CAMK10.89509469
74CDK150.89263321
75PRKD20.88668344
76WNK10.87597471
77PDPK10.86047281
78SYK0.83984098
79IRAK40.83595187
80NEK10.83580135
81MAPK130.81397273
82JAK20.81029172
83CAMK2G0.79944000
84CDK11A0.78886009
85CAMK2D0.78350291
86DAPK30.77356735
87HCK0.76536789
88LIMK10.75566059
89TAOK10.75251837
90KSR10.74781681
91JAK10.73926893
92PDK10.72945947
93RET0.72748124
94TYRO30.72551914
95PAK30.72369631
96CCNB10.70630093
97MAPK150.69548503
98TNK20.68753393
99IRAK20.68217816
100FGFR40.67712636
101SGK20.67506467
102BRAF0.67299263
103SGK30.65808600
104PRKG20.65039861
105FYN0.63587666
106SMG10.61176444
107BMPR20.60814505
108HIPK20.59477269
109ALK0.58207323
110BTK0.57728480
111PRKCE0.56553754
112FER0.56525436
113MAP2K10.55271534
114MARK20.55253365
115EPHB10.53138717
116PDK40.52275267
117PDK30.52275267
118PRKD10.51893612
119AKT30.49162011
120RPS6KA20.49075822
121ROCK20.48853430
122DYRK1B0.48133354
123FGR0.48001080
124STK110.46819498
125SGK10.46435686
126PRKCZ0.45584952
127RAF10.45141529
128BCR0.44808397
129DYRK1A0.44001310
130MAP3K110.43201749
131MATK0.43146264
132CAMK40.41191677
133CDC42BPA0.40620819
134MYLK0.39845978
135SIK20.38335997
136MAP2K60.37262915
137RPS6KA30.37195092
138GRK70.36715245
139PKN10.35903361

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.13082791
2Collecting duct acid secretion_Homo sapiens_hsa049662.95902511
3Nicotine addiction_Homo sapiens_hsa050332.91274452
4GABAergic synapse_Homo sapiens_hsa047272.55373915
5Olfactory transduction_Homo sapiens_hsa047402.48651555
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29994893
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29380954
8Circadian entrainment_Homo sapiens_hsa047132.29248188
9Glutamatergic synapse_Homo sapiens_hsa047242.14100096
10Morphine addiction_Homo sapiens_hsa050322.13617137
11Long-term potentiation_Homo sapiens_hsa047201.97430999
12Amphetamine addiction_Homo sapiens_hsa050311.96802342
13Insulin secretion_Homo sapiens_hsa049111.90510100
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85080977
15Vibrio cholerae infection_Homo sapiens_hsa051101.81844475
16Dopaminergic synapse_Homo sapiens_hsa047281.79672849
17Salivary secretion_Homo sapiens_hsa049701.75598048
18Osteoclast differentiation_Homo sapiens_hsa043801.62141530
19Gastric acid secretion_Homo sapiens_hsa049711.61598180
20Taste transduction_Homo sapiens_hsa047421.61210331
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60343490
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53074642
23Cholinergic synapse_Homo sapiens_hsa047251.47018113
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46128756
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45797941
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42219521
27VEGF signaling pathway_Homo sapiens_hsa043701.36472412
28Serotonergic synapse_Homo sapiens_hsa047261.35835241
29Nitrogen metabolism_Homo sapiens_hsa009101.35294685
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34868756
31Cocaine addiction_Homo sapiens_hsa050301.33957664
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30237184
33Long-term depression_Homo sapiens_hsa047301.29788281
34Renin secretion_Homo sapiens_hsa049241.28167264
35Oxidative phosphorylation_Homo sapiens_hsa001901.23488560
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23395126
37B cell receptor signaling pathway_Homo sapiens_hsa046621.23350869
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21800131
39Other glycan degradation_Homo sapiens_hsa005111.19479556
40Oxytocin signaling pathway_Homo sapiens_hsa049211.18784538
41Calcium signaling pathway_Homo sapiens_hsa040201.18117344
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14678950
43Tuberculosis_Homo sapiens_hsa051521.14605756
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13802436
45Chemokine signaling pathway_Homo sapiens_hsa040621.13696556
46Cardiac muscle contraction_Homo sapiens_hsa042601.12389155
47Leishmaniasis_Homo sapiens_hsa051401.08945743
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05293997
49Staphylococcus aureus infection_Homo sapiens_hsa051501.04608750
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03421560
51Platelet activation_Homo sapiens_hsa046111.03045926
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02276910
53Phototransduction_Homo sapiens_hsa047441.01217928
54GnRH signaling pathway_Homo sapiens_hsa049120.99767898
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97556106
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.97285629
57Acute myeloid leukemia_Homo sapiens_hsa052210.97019837
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97005332
59cAMP signaling pathway_Homo sapiens_hsa040240.96126839
60Gap junction_Homo sapiens_hsa045400.94938045
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94010834
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90725396
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89819562
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87094232
65Non-small cell lung cancer_Homo sapiens_hsa052230.86559747
66Type II diabetes mellitus_Homo sapiens_hsa049300.85553358
67Malaria_Homo sapiens_hsa051440.84380003
68Parkinsons disease_Homo sapiens_hsa050120.83861448
69Alzheimers disease_Homo sapiens_hsa050100.80408650
70Rheumatoid arthritis_Homo sapiens_hsa053230.79296364
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78781656
72Salmonella infection_Homo sapiens_hsa051320.78186002
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77950121
74T cell receptor signaling pathway_Homo sapiens_hsa046600.72183386
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.72061588
76Pyruvate metabolism_Homo sapiens_hsa006200.71586040
77Fatty acid elongation_Homo sapiens_hsa000620.70832622
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.70478997
79Butanoate metabolism_Homo sapiens_hsa006500.70015268
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69638615
81Rap1 signaling pathway_Homo sapiens_hsa040150.69120858
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.68869177
83Pertussis_Homo sapiens_hsa051330.68827336
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68370157
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68001930
86Estrogen signaling pathway_Homo sapiens_hsa049150.67657902
87African trypanosomiasis_Homo sapiens_hsa051430.67030939
88Pancreatic secretion_Homo sapiens_hsa049720.66561469
89Bile secretion_Homo sapiens_hsa049760.65626662
90Insulin signaling pathway_Homo sapiens_hsa049100.65408459
91Renal cell carcinoma_Homo sapiens_hsa052110.64499439
92Lysosome_Homo sapiens_hsa041420.63569993
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63401445
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63170284
95TNF signaling pathway_Homo sapiens_hsa046680.60863104
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60214259
97ErbB signaling pathway_Homo sapiens_hsa040120.59937547
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59912266
99Thyroid hormone synthesis_Homo sapiens_hsa049180.59631924
100Prion diseases_Homo sapiens_hsa050200.59383406
101Glioma_Homo sapiens_hsa052140.58890870
102Chronic myeloid leukemia_Homo sapiens_hsa052200.58877423
103Endometrial cancer_Homo sapiens_hsa052130.58306011
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.58063954
105mTOR signaling pathway_Homo sapiens_hsa041500.57122339
106Endocytosis_Homo sapiens_hsa041440.56927848
107Toxoplasmosis_Homo sapiens_hsa051450.56927845
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56916175
109Notch signaling pathway_Homo sapiens_hsa043300.56640902
110Hepatitis C_Homo sapiens_hsa051600.56490084
111Arginine biosynthesis_Homo sapiens_hsa002200.55937255
112Melanogenesis_Homo sapiens_hsa049160.53501164
113HIF-1 signaling pathway_Homo sapiens_hsa040660.53364321
114Axon guidance_Homo sapiens_hsa043600.53226373
115Shigellosis_Homo sapiens_hsa051310.52543481
116Pancreatic cancer_Homo sapiens_hsa052120.52534208
117Phagosome_Homo sapiens_hsa041450.48589116
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.46832824
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46706995
120Dorso-ventral axis formation_Homo sapiens_hsa043200.45486172
121Glucagon signaling pathway_Homo sapiens_hsa049220.44058515
122Choline metabolism in cancer_Homo sapiens_hsa052310.43553002
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43418748
124Dilated cardiomyopathy_Homo sapiens_hsa054140.42902724
125MAPK signaling pathway_Homo sapiens_hsa040100.42095352
126Type I diabetes mellitus_Homo sapiens_hsa049400.41866664
127Vitamin B6 metabolism_Homo sapiens_hsa007500.38214699
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37572169
129Fructose and mannose metabolism_Homo sapiens_hsa000510.37539966
130Circadian rhythm_Homo sapiens_hsa047100.37084099
131Inositol phosphate metabolism_Homo sapiens_hsa005620.37060633
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.36239021
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.34868641
134Ether lipid metabolism_Homo sapiens_hsa005650.34290646
135Ras signaling pathway_Homo sapiens_hsa040140.34180591
136Huntingtons disease_Homo sapiens_hsa050160.33411805
137Regulation of autophagy_Homo sapiens_hsa041400.32523347
138Carbon metabolism_Homo sapiens_hsa012000.30444536
139Oocyte meiosis_Homo sapiens_hsa041140.28613021
140Biosynthesis of amino acids_Homo sapiens_hsa012300.28243594

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »