WBP2NL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.76859509
2acrosome assembly (GO:0001675)9.60704439
3multicellular organism reproduction (GO:0032504)9.40585123
4cell-cell recognition (GO:0009988)9.31459112
5spermatid development (GO:0007286)9.14276912
6epithelial cilium movement (GO:0003351)8.77671934
7axonemal dynein complex assembly (GO:0070286)8.65866827
8plasma membrane fusion (GO:0045026)8.43402998
9motile cilium assembly (GO:0044458)8.42550016
10reproduction (GO:0000003)8.23833750
11regulation of cilium movement (GO:0003352)8.05983989
12piRNA metabolic process (GO:0034587)7.78824846
13synaptonemal complex assembly (GO:0007130)7.37235242
14synaptonemal complex organization (GO:0070193)7.32638533
15cilium or flagellum-dependent cell motility (GO:0001539)7.11921576
16cilium movement (GO:0003341)6.92979163
17male meiosis (GO:0007140)6.90997170
18microtubule depolymerization (GO:0007019)6.81253200
19negative regulation of inclusion body assembly (GO:0090084)6.77522258
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.57645786
21single fertilization (GO:0007338)6.51490792
22spermatogenesis (GO:0007283)6.48215411
23male gamete generation (GO:0048232)6.46523947
24sperm capacitation (GO:0048240)6.02831795
25gamete generation (GO:0007276)5.99065878
26chromosome condensation (GO:0030261)5.82400930
27fertilization (GO:0009566)5.78073575
28organic cation transport (GO:0015695)5.71420655
29regulation of inclusion body assembly (GO:0090083)5.67547421
30response to pheromone (GO:0019236)5.62390662
31DNA packaging (GO:0006323)5.54150842
32germ cell development (GO:0007281)5.33709140
33chromosome organization involved in meiosis (GO:0070192)5.19415634
34male meiosis I (GO:0007141)5.18745319
35DNA methylation involved in gamete generation (GO:0043046)5.17085773
36cellular process involved in reproduction in multicellular organism (GO:0022412)5.07970721
37single strand break repair (GO:0000012)4.89988260
38spermatid nucleus differentiation (GO:0007289)4.87523099
39regulation of microtubule-based movement (GO:0060632)4.83722982
40meiotic nuclear division (GO:0007126)4.80583138
41calcium ion-dependent exocytosis (GO:0017156)4.78288396
42multicellular organismal reproductive process (GO:0048609)4.69897831
43indole-containing compound catabolic process (GO:0042436)4.69440896
44indolalkylamine catabolic process (GO:0046218)4.69440896
45tryptophan catabolic process (GO:0006569)4.69440896
46behavioral response to nicotine (GO:0035095)4.64351069
47microtubule severing (GO:0051013)4.50373530
48glycerol ether metabolic process (GO:0006662)4.43779506
49meiosis I (GO:0007127)4.34681364
50cell recognition (GO:0008037)4.34160885
51seminiferous tubule development (GO:0072520)4.30016977
52detection of light stimulus involved in sensory perception (GO:0050962)4.27949800
53detection of light stimulus involved in visual perception (GO:0050908)4.27949800
54L-fucose metabolic process (GO:0042354)4.26286607
55L-fucose catabolic process (GO:0042355)4.26286607
56fucose catabolic process (GO:0019317)4.26286607
57ventricular system development (GO:0021591)4.23196269
58chaperone-mediated protein complex assembly (GO:0051131)4.22904400
59indolalkylamine metabolic process (GO:0006586)4.18694082
60tryptophan metabolic process (GO:0006568)4.16292672
61sexual reproduction (GO:0019953)4.15203945
62ether metabolic process (GO:0018904)4.08896264
63cellular ketone body metabolic process (GO:0046950)4.08158743
64kynurenine metabolic process (GO:0070189)3.83953371
65regulation of spindle checkpoint (GO:0090231)3.77615568
66water-soluble vitamin biosynthetic process (GO:0042364)3.76503688
67multicellular organismal development (GO:0007275)3.69920316
68DNA deamination (GO:0045006)3.69492791
69ketone body metabolic process (GO:1902224)3.68481848
70interferon-gamma secretion (GO:0072643)3.63458066
71left/right pattern formation (GO:0060972)3.60376852
72mitotic sister chromatid cohesion (GO:0007064)3.58292190
73microtubule polymerization or depolymerization (GO:0031109)3.55171675
74indole-containing compound metabolic process (GO:0042430)3.50637831
75meiotic cell cycle process (GO:1903046)3.48332240
76adaptation of signaling pathway (GO:0023058)3.47044640
77monoubiquitinated protein deubiquitination (GO:0035520)3.42468132
78gamma-aminobutyric acid transport (GO:0015812)3.39106205
79amine catabolic process (GO:0009310)3.32442907
80cellular biogenic amine catabolic process (GO:0042402)3.32442907
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30321605
82chromatin silencing (GO:0006342)3.24450340
83protein polyglutamylation (GO:0018095)3.24219507
84detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23093228
85sequestering of actin monomers (GO:0042989)3.21372071
86DNA double-strand break processing (GO:0000729)3.20196468
87histone exchange (GO:0043486)3.19279340
88protein K11-linked deubiquitination (GO:0035871)3.19034916
89gene silencing by RNA (GO:0031047)3.16130376
90protein localization to chromosome, centromeric region (GO:0071459)3.15305712
91protein refolding (GO:0042026)3.13583589
92axoneme assembly (GO:0035082)3.09829614
93polyamine biosynthetic process (GO:0006596)3.09788881
94protein complex biogenesis (GO:0070271)3.09457887
95synapsis (GO:0007129)3.08305325
96* meiotic cell cycle (GO:0051321)3.04886658
97sulfation (GO:0051923)3.04359510
98establishment of protein localization to Golgi (GO:0072600)3.03460182
99genitalia morphogenesis (GO:0035112)3.02714120
100* nucleus organization (GO:0006997)2.99900081
101regulation of meiosis I (GO:0060631)2.97597171
102respiratory chain complex IV assembly (GO:0008535)2.97303766
103gene silencing (GO:0016458)2.94837725
104reflex (GO:0060004)2.92383590
105RNA localization (GO:0006403)2.91201574
106photoreceptor cell maintenance (GO:0045494)2.91096070
107rRNA methylation (GO:0031167)2.90920147
108cytochrome complex assembly (GO:0017004)2.89609824
109primary amino compound metabolic process (GO:1901160)2.89536348
110cAMP catabolic process (GO:0006198)2.89223959
111glycolytic process (GO:0006096)2.89098125
112protein-cofactor linkage (GO:0018065)2.88571664
113neuronal action potential propagation (GO:0019227)2.88422722
114DNA replication-dependent nucleosome organization (GO:0034723)2.86456314
115DNA replication-dependent nucleosome assembly (GO:0006335)2.86456314
116rRNA modification (GO:0000154)2.82115217
117negative regulation of DNA-dependent DNA replication (GO:2000104)2.81560009
118mitochondrial respiratory chain complex assembly (GO:0033108)2.80851033
119neuronal action potential (GO:0019228)2.79979710
120nucleoside diphosphate phosphorylation (GO:0006165)2.78789687
121RNA destabilization (GO:0050779)2.77223282
122signal peptide processing (GO:0006465)2.76460815
123protein targeting to Golgi (GO:0000042)2.76453241
124mitochondrial respiratory chain complex I assembly (GO:0032981)2.76171347
125NADH dehydrogenase complex assembly (GO:0010257)2.76171347
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76171347
127nuclear pore complex assembly (GO:0051292)2.72478351
128NAD biosynthetic process (GO:0009435)2.72424043
129aromatic amino acid family catabolic process (GO:0009074)2.71218571
130sister chromatid cohesion (GO:0007062)2.69755340
131GTP biosynthetic process (GO:0006183)2.69644927
132dopamine transport (GO:0015872)2.68584831
133replication fork processing (GO:0031297)2.68009462
134protein localization to Golgi apparatus (GO:0034067)2.67732949
135amino-acid betaine transport (GO:0015838)2.66574460
136carnitine transport (GO:0015879)2.66574460
137reciprocal DNA recombination (GO:0035825)2.66385732
138reciprocal meiotic recombination (GO:0007131)2.66385732
139platelet dense granule organization (GO:0060155)2.64992442
140serotonin metabolic process (GO:0042428)2.64227688
141regulation of histone H3-K9 methylation (GO:0051570)2.63166189
142protein complex localization (GO:0031503)2.63079528
143cyclic nucleotide catabolic process (GO:0009214)2.62802378
144centriole replication (GO:0007099)2.62594478
145chromosome organization (GO:0051276)2.61104278
146RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61054044
147spinal cord motor neuron differentiation (GO:0021522)2.61006296
148heterochromatin organization (GO:0070828)2.60958980
149phosphatidylinositol acyl-chain remodeling (GO:0036149)2.60372534
150startle response (GO:0001964)2.57488624
151UTP biosynthetic process (GO:0006228)2.57241988
152regulation of action potential (GO:0098900)2.57132105
153cellular response to ATP (GO:0071318)2.53423641
154negative regulation of mast cell activation (GO:0033004)2.53376979
155negative regulation of telomere maintenance (GO:0032205)2.53216830
156polyol catabolic process (GO:0046174)2.52385141
157negative regulation of gene expression, epigenetic (GO:0045814)2.51829387
158auditory receptor cell stereocilium organization (GO:0060088)2.50651882
159positive regulation of macrophage activation (GO:0043032)2.50527948
160benzene-containing compound metabolic process (GO:0042537)2.50361386
161retinal cone cell development (GO:0046549)2.47470129
162retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46217835
163double-strand break repair via homologous recombination (GO:0000724)2.45891792
164recombinational repair (GO:0000725)2.45818942
165kidney morphogenesis (GO:0060993)2.45616239
166C4-dicarboxylate transport (GO:0015740)2.44964638
167regulation of hexokinase activity (GO:1903299)2.44672606
168regulation of glucokinase activity (GO:0033131)2.44672606
169regulation of nuclear cell cycle DNA replication (GO:0033262)2.43095398
170preassembly of GPI anchor in ER membrane (GO:0016254)2.42920400
171behavioral response to ethanol (GO:0048149)2.42501262
172nonmotile primary cilium assembly (GO:0035058)2.42176922
173nephron tubule morphogenesis (GO:0072078)2.42046258
174sperm motility (GO:0030317)12.6890580
175cell wall macromolecule catabolic process (GO:0016998)11.5468063
176cell wall macromolecule metabolic process (GO:0044036)11.5468063
177fusion of sperm to egg plasma membrane (GO:0007342)11.1889483
178acrosome reaction (GO:0007340)10.9968195
179sperm-egg recognition (GO:0035036)10.4501111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.07532572
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96979455
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.93032187
4EZH2_22144423_ChIP-Seq_EOC_Human2.92716246
5* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.70219880
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67034362
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66276892
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58571947
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.55603132
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36857164
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35136909
12VDR_22108803_ChIP-Seq_LS180_Human2.34369544
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32053451
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23148218
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19972452
16IGF1R_20145208_ChIP-Seq_DFB_Human2.16824767
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14727385
18FUS_26573619_Chip-Seq_HEK293_Human2.14082822
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09384776
20P300_19829295_ChIP-Seq_ESCs_Human2.08413195
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.1347366
22TAF15_26573619_Chip-Seq_HEK293_Human1.99623449
23EWS_26573619_Chip-Seq_HEK293_Human1.98934798
24ER_23166858_ChIP-Seq_MCF-7_Human1.97502527
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.95929867
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.83213124
27* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82106032
28ZNF274_21170338_ChIP-Seq_K562_Hela1.79744380
29KAP1_22055183_ChIP-Seq_ESCs_Mouse1.74907678
30GATA3_21867929_ChIP-Seq_CD8_Mouse1.73011497
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67267604
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66362202
33SOX2_22085726_ChIP-Seq_NPCs_Mouse1.65813250
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.64924495
35* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64850801
36AR_25329375_ChIP-Seq_VCAP_Human1.62821294
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61386513
38ELK4_26923725_Chip-Seq_MESODERM_Mouse1.61107705
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.60741231
40STAT1_17558387_ChIP-Seq_HELA_Human1.60494914
41BCAT_22108803_ChIP-Seq_LS180_Human1.55966852
42STAT3_23295773_ChIP-Seq_U87_Human1.54320096
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50512135
44SMAD4_21799915_ChIP-Seq_A2780_Human1.48596753
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48215754
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.46608860
47MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46257199
48* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44654617
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.44439904
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44439904
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43580572
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42755293
53TCF4_23295773_ChIP-Seq_U87_Human1.40614716
54TP53_22573176_ChIP-Seq_HFKS_Human1.40452947
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40299752
56TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.39703584
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.39423531
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39379497
59NANOG_19829295_ChIP-Seq_ESCs_Human1.38581360
60SOX2_19829295_ChIP-Seq_ESCs_Human1.38581360
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.37643878
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.37384547
63GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.36626135
64* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35116433
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34857503
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34736343
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.34080885
68GATA3_21867929_ChIP-Seq_TH1_Mouse1.33891744
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32080159
70IRF1_19129219_ChIP-ChIP_H3396_Human1.32035548
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.31779599
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31705559
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30604691
74RUNX2_22187159_ChIP-Seq_PCA_Human1.29558888
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28918588
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28108988
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.27930040
78TCF4_22108803_ChIP-Seq_LS180_Human1.26998329
79SPI1_26923725_Chip-Seq_HPCs_Mouse1.25963291
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25250864
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.24940440
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.24323694
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24186712
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24111223
85P53_21459846_ChIP-Seq_SAOS-2_Human1.24102846
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23899305
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23640616
88MYC_18940864_ChIP-ChIP_HL60_Human1.23493319
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.23467025
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23017165
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22624424
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.22497727
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.22454790
94CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22050998
95SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.21854690
96* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21809404
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21345519
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20975041
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.20189700
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.19948745
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.19604768
102EST1_17652178_ChIP-ChIP_JURKAT_Human1.18198619
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17148352
104NCOR_22424771_ChIP-Seq_293T_Human1.16873972
105RAD21_21589869_ChIP-Seq_MESCs_Mouse1.15087487
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.14215039
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.13940235
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13801397
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13310667
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13249552
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11482719
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11423337
113KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11391500
114P53_22387025_ChIP-Seq_ESCs_Mouse1.10725836
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10061870
116CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09652409
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.09260449
118RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09152161
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07288312
120ESET_19884257_ChIP-Seq_ESCs_Mouse1.06193485
121AR_20517297_ChIP-Seq_VCAP_Human1.06077530
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05649201
123* RARA_24833708_ChIP-Seq_LIVER_Mouse1.05399191
124HOXB7_26014856_ChIP-Seq_BT474_Human1.05323210
125AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05127715
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05110272
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04829532
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.04715698
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04639110
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04407682
131ERG_20517297_ChIP-Seq_VCAP_Human1.03693429
132CTCF_20526341_ChIP-Seq_ESCs_Human1.03523796
133KDM2B_26808549_Chip-Seq_REH_Human1.03360429
134E2F1_18555785_Chip-Seq_ESCs_Mouse1.02885320
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02876008
136JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02609981
137E2F7_22180533_ChIP-Seq_HELA_Human1.01902908
138GF1_26923725_Chip-Seq_HPCs_Mouse1.01843188
139CDX2_22108803_ChIP-Seq_LS180_Human1.01709470
140FLI1_21867929_ChIP-Seq_CD8_Mouse1.01372667
141* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00665266
142RNF2_27304074_Chip-Seq_NSC_Mouse1.00316970
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00171652
144P300_18555785_Chip-Seq_ESCs_Mouse1.00045773
145PHF8_20622854_ChIP-Seq_HELA_Human0.98107539
146SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96949398
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96819481
148PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96585325
149ELF1_20517297_ChIP-Seq_JURKAT_Human0.95859932
150MYC_19829295_ChIP-Seq_ESCs_Human0.95857129
151SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95455765
152MYC_27129775_Chip-Seq_CORNEA_Mouse0.94641755
153BCOR_27268052_Chip-Seq_Bcells_Human0.94367882
154STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94367124
155SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93440239
156GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93396374
157CBP_20019798_ChIP-Seq_JUKART_Human0.92136958
158IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92136958
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90735766
160POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90735766
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90176281
162CTCF_26484167_Chip-Seq_Bcells_Mouse0.90100514
163NFYB_21822215_ChIP-Seq_K562_Human0.90050957
164* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88433621
165SOX2_21211035_ChIP-Seq_LN229_Human0.88285872
166ETV1_20927104_ChIP-Seq_GIST48_Human0.88102113
167NANOG_20526341_ChIP-Seq_ESCs_Human0.87458781
168* REST_21632747_ChIP-Seq_MESCs_Mouse0.86911650
169FLI1_21867929_ChIP-Seq_TH2_Mouse0.86529740
170RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85849196
171SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85587844
172TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85222905
173PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83435344
174CRX_20693478_ChIP-Seq_RETINA_Mouse0.83076326
175RAC3_21632823_ChIP-Seq_H3396_Human0.80213304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.78558810
2MP0001929_abnormal_gametogenesis5.61088879
3MP0008877_abnormal_DNA_methylation4.90911859
4MP0002210_abnormal_sex_determination3.70721220
5MP0002161_abnormal_fertility/fecundity3.30381328
6MP0001145_abnormal_male_reproductive3.13750259
7MP0000653_abnormal_sex_gland2.78528489
8MP0000569_abnormal_digit_pigmentation2.75988475
9MP0005670_abnormal_white_adipose2.72277257
10MP0003195_calcinosis2.63034839
11MP0001968_abnormal_touch/_nociception2.60527780
12MP0008875_abnormal_xenobiotic_pharmacok2.44233791
13MP0005551_abnormal_eye_electrophysiolog2.44023314
14MP0002138_abnormal_hepatobiliary_system2.24914508
15MP0002653_abnormal_ependyma_morphology2.24638784
16MP0008872_abnormal_physiological_respon2.14310986
17MP0002837_dystrophic_cardiac_calcinosis2.12619613
18MP0010094_abnormal_chromosome_stability2.12449285
19MP0009745_abnormal_behavioral_response2.12335025
20MP0002736_abnormal_nociception_after2.04152671
21MP0008058_abnormal_DNA_repair2.00538719
22MP0003111_abnormal_nucleus_morphology2.00236710
23MP0005410_abnormal_fertilization14.7084467
24MP0005645_abnormal_hypothalamus_physiol1.98955913
25MP0002876_abnormal_thyroid_physiology1.98396032
26MP0003646_muscle_fatigue1.97614379
27MP0002272_abnormal_nervous_system1.83226954
28MP0006292_abnormal_olfactory_placode1.80834897
29MP0005379_endocrine/exocrine_gland_phen1.70325496
30MP0004142_abnormal_muscle_tone1.69109108
31MP0005646_abnormal_pituitary_gland1.67202022
32MP0002160_abnormal_reproductive_system1.65021163
33MP0001486_abnormal_startle_reflex1.64192210
34MP0005084_abnormal_gallbladder_morpholo1.63793369
35MP0003693_abnormal_embryo_hatching1.62874569
36MP0000372_irregular_coat_pigmentation1.61666227
37MP0001501_abnormal_sleep_pattern1.54963516
38MP0008057_abnormal_DNA_replication1.51948978
39MP0004957_abnormal_blastocyst_morpholog1.51886844
40MP0004233_abnormal_muscle_weight1.51761784
41MP0003880_abnormal_central_pattern1.47723358
42MP0002572_abnormal_emotion/affect_behav1.46016977
43MP0004147_increased_porphyrin_level1.43015591
44MP0001485_abnormal_pinna_reflex1.42317198
45MP0001905_abnormal_dopamine_level1.41972483
46MP0003077_abnormal_cell_cycle1.39270651
47MP0004043_abnormal_pH_regulation1.34487414
48MP0002735_abnormal_chemical_nociception1.33853824
49MP0000631_abnormal_neuroendocrine_gland1.32987072
50MP0002064_seizures1.29844833
51MP0008995_early_reproductive_senescence1.29264065
52MP0002254_reproductive_system_inflammat1.28514208
53MP0002733_abnormal_thermal_nociception1.26500455
54MP0001970_abnormal_pain_threshold1.25715632
55MP0001986_abnormal_taste_sensitivity1.25682947
56MP0004885_abnormal_endolymph1.25087893
57MP0005174_abnormal_tail_pigmentation1.24543434
58MP0000427_abnormal_hair_cycle1.22741291
59MP0002557_abnormal_social/conspecific_i1.22408822
60MP0005423_abnormal_somatic_nervous1.16601798
61MP0006276_abnormal_autonomic_nervous1.14881637
62MP0005075_abnormal_melanosome_morpholog1.14574390
63MP0003718_maternal_effect1.14521332
64MP0002067_abnormal_sensory_capabilities1.13712490
65MP0004924_abnormal_behavior1.12733530
66MP0005386_behavior/neurological_phenoty1.12733530
67MP0005360_urolithiasis1.09409664
68MP0004742_abnormal_vestibular_system1.09049250
69MP0001529_abnormal_vocalization1.06214420
70MP0001730_embryonic_growth_arrest1.06069436
71MP0004145_abnormal_muscle_electrophysio1.04059162
72MP0003252_abnormal_bile_duct1.03990216
73MP0003635_abnormal_synaptic_transmissio1.03892020
74MP0002693_abnormal_pancreas_physiology1.03402748
75MP0003786_premature_aging1.02394600
76MP0002734_abnormal_mechanical_nocicepti1.02368816
77MP0005389_reproductive_system_phenotype1.02288409
78MP0002938_white_spotting1.00313022
79MP0002928_abnormal_bile_duct1.00117373
80MP0002063_abnormal_learning/memory/cond0.99653820
81MP0005332_abnormal_amino_acid0.96231329
82MP0002282_abnormal_trachea_morphology0.95281874
83MP0000015_abnormal_ear_pigmentation0.95088469
84MP0005310_abnormal_salivary_gland0.94367092
85MP0008932_abnormal_embryonic_tissue0.93376253
86MP0004133_heterotaxia0.91835132
87MP0000230_abnormal_systemic_arterial0.91179897
88MP0010386_abnormal_urinary_bladder0.89613888
89MP0003699_abnormal_female_reproductive0.88531675
90MP0004215_abnormal_myocardial_fiber0.87576559
91MP0002229_neurodegeneration0.87096567
92MP0005167_abnormal_blood-brain_barrier0.86634638
93MP0002638_abnormal_pupillary_reflex0.79238740
94MP0005647_abnormal_sex_gland0.79227109
95MP0005195_abnormal_posterior_eye0.78997277
96MP0003121_genomic_imprinting0.77410011
97MP0005623_abnormal_meninges_morphology0.76850366
98MP0000538_abnormal_urinary_bladder0.76579179
99MP0008007_abnormal_cellular_replicative0.75926222
100MP0001963_abnormal_hearing_physiology0.75827432
101MP0001765_abnormal_ion_homeostasis0.74418134
102MP0003137_abnormal_impulse_conducting0.74226752
103MP0001944_abnormal_pancreas_morphology0.74207560
104MP0001440_abnormal_grooming_behavior0.73926799
105MP0005671_abnormal_response_to0.73885408
106MP0001119_abnormal_female_reproductive0.71283842
107MP0001984_abnormal_olfaction0.71149831
108MP0002084_abnormal_developmental_patter0.69147212
109MP0005380_embryogenesis_phenotype0.69086011
110MP0001672_abnormal_embryogenesis/_devel0.69086011
111MP0001697_abnormal_embryo_size0.67614746
112MP0001293_anophthalmia0.67377001
113MP0003878_abnormal_ear_physiology0.66398491
114MP0005377_hearing/vestibular/ear_phenot0.66398491
115MP0003115_abnormal_respiratory_system0.65943199
116MP0000358_abnormal_cell_content/0.65410608
117MP0002085_abnormal_embryonic_tissue0.63213479
118MP0003136_yellow_coat_color0.61616252
119MP0002234_abnormal_pharynx_morphology0.60562990
120MP0010307_abnormal_tumor_latency0.59991026
121MP0000350_abnormal_cell_proliferation0.58257488
122MP0002080_prenatal_lethality0.56102506
123MP0002269_muscular_atrophy0.55491753
124MP0005666_abnormal_adipose_tissue0.54879245
125MP0005397_hematopoietic_system_phenotyp0.53425566
126MP0001545_abnormal_hematopoietic_system0.53425566
127MP0009278_abnormal_bone_marrow0.52856194
128MP0000313_abnormal_cell_death0.52291789
129MP0002796_impaired_skin_barrier0.51056877
130MP0006036_abnormal_mitochondrial_physio0.49303992
131MP0001764_abnormal_homeostasis0.48579133
132MP0003984_embryonic_growth_retardation0.47725944
133MP0003011_delayed_dark_adaptation0.45613963
134MP0004197_abnormal_fetal_growth/weight/0.45104190
135MP0003315_abnormal_perineum_morphology0.44966069
136MP0002088_abnormal_embryonic_growth/wei0.44909255
137MP0003941_abnormal_skin_development0.43321645
138MP0003861_abnormal_nervous_system0.40753268
139MP0002102_abnormal_ear_morphology0.40527166
140MP0003950_abnormal_plasma_membrane0.40250180
141MP0005395_other_phenotype0.39963735
142MP0003123_paternal_imprinting0.39739043
143MP0002086_abnormal_extraembryonic_tissu0.39105508
144MP0005451_abnormal_body_composition0.38564762
145MP0001324_abnormal_eye_pigmentation0.38308510
146MP0003936_abnormal_reproductive_system0.37985445
147MP0005391_vision/eye_phenotype0.34844135
148MP0006072_abnormal_retinal_apoptosis0.34640416
149MP0005636_abnormal_mineral_homeostasis0.34608790
150MP0000534_abnormal_ureter_morphology0.33903956
151MP0004019_abnormal_vitamin_homeostasis0.33724432
152MP0002169_no_abnormal_phenotype0.33462576
153MP0006035_abnormal_mitochondrial_morpho0.33145765
154MP0002873_normal_phenotype0.32984947
155MP0002092_abnormal_eye_morphology0.32923126
156MP0004036_abnormal_muscle_relaxation0.32200413
157MP0009672_abnormal_birth_weight0.32157894
158MP0005253_abnormal_eye_physiology0.30055928
159MP0002019_abnormal_tumor_incidence0.29923088
160MP0001849_ear_inflammation0.28221851
161MP0003119_abnormal_digestive_system0.27687524
162MP0000462_abnormal_digestive_system0.27596077
163MP0001727_abnormal_embryo_implantation0.27026054
164MP0009115_abnormal_fat_cell0.26146530
165MP0001919_abnormal_reproductive_system0.25652027
166MP0002163_abnormal_gland_morphology0.25577494
167MP0009046_muscle_twitch0.25350444
168MP0003787_abnormal_imprinting0.24779718
169MP0000001_mammalian_phenotype0.23317351
170MP0003942_abnormal_urinary_system0.22488792
171MP0008770_decreased_survivor_rate0.21943094
172MP0003890_abnormal_embryonic-extraembry0.21857425

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.03264951
2Abnormal respiratory motile cilium morphology (HP:0005938)9.03264951
3Abnormal respiratory motile cilium physiology (HP:0012261)8.72514448
4Infertility (HP:0000789)7.15483796
5Rhinitis (HP:0012384)6.97896316
6Chronic bronchitis (HP:0004469)6.94449826
7Abnormal ciliary motility (HP:0012262)6.72096047
8Nasal polyposis (HP:0100582)5.82050046
9Male infertility (HP:0003251)5.63424045
10Abnormality of the nasal mucosa (HP:0000433)4.66883219
11Abnormal spermatogenesis (HP:0008669)4.35416534
12Bronchitis (HP:0012387)4.16533391
13Bronchiectasis (HP:0002110)4.14644440
14Congenital stationary night blindness (HP:0007642)4.10908794
15Nephronophthisis (HP:0000090)4.03205172
16Impulsivity (HP:0100710)3.68218164
17Attenuation of retinal blood vessels (HP:0007843)3.61268839
18Abnormal rod and cone electroretinograms (HP:0008323)3.56527739
19Gaze-evoked nystagmus (HP:0000640)3.03043825
20Recurrent otitis media (HP:0000403)3.00361152
21Hyperventilation (HP:0002883)2.98692430
22Abolished electroretinogram (ERG) (HP:0000550)2.96737840
23Abnormality of the renal medulla (HP:0100957)2.93114175
24Pendular nystagmus (HP:0012043)2.90348002
25Type II lissencephaly (HP:0007260)2.89425590
26Azoospermia (HP:0000027)2.82842747
27Congenital, generalized hypertrichosis (HP:0004540)2.79416537
28Recurrent sinusitis (HP:0011108)2.79334698
29Tubular atrophy (HP:0000092)2.73518952
30Tubulointerstitial nephritis (HP:0001970)2.66433356
31Inability to walk (HP:0002540)2.66030692
32Chronic hepatic failure (HP:0100626)2.62842993
33Bony spicule pigmentary retinopathy (HP:0007737)2.61863979
34Abnormality of midbrain morphology (HP:0002418)2.56348249
35Molar tooth sign on MRI (HP:0002419)2.56348249
36Gonadotropin excess (HP:0000837)2.52937968
37Progressive inability to walk (HP:0002505)2.50762485
38Renal cortical cysts (HP:0000803)2.42377215
39Severe visual impairment (HP:0001141)2.39992288
40Hemiparesis (HP:0001269)2.39539985
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39504176
42Fair hair (HP:0002286)2.36716275
43Methylmalonic acidemia (HP:0002912)2.35700019
44Congenital sensorineural hearing impairment (HP:0008527)2.35036602
45Abnormality of macular pigmentation (HP:0008002)2.33287112
46Recurrent bronchitis (HP:0002837)2.31255769
47Hypothermia (HP:0002045)2.26203761
48Increased corneal curvature (HP:0100692)2.26094677
49Keratoconus (HP:0000563)2.26094677
50Polyuria (HP:0000103)2.25446559
51Acute necrotizing encephalopathy (HP:0006965)2.23669615
52Progressive cerebellar ataxia (HP:0002073)2.22623344
53Hepatic necrosis (HP:0002605)2.21055723
54Progressive macrocephaly (HP:0004481)2.20319104
55Medial flaring of the eyebrow (HP:0010747)2.19908019
56Mitochondrial inheritance (HP:0001427)2.19269468
57Abnormal gallbladder physiology (HP:0012438)2.17581774
58Cholecystitis (HP:0001082)2.17581774
59Large for gestational age (HP:0001520)2.17565456
60Sclerocornea (HP:0000647)2.16584902
61Febrile seizures (HP:0002373)2.15192863
62Increased CSF lactate (HP:0002490)2.14498223
63Tubulointerstitial abnormality (HP:0001969)2.12747245
64Furrowed tongue (HP:0000221)2.07534401
653-Methylglutaconic aciduria (HP:0003535)2.07287768
66Hepatocellular necrosis (HP:0001404)2.07253414
67Spastic tetraparesis (HP:0001285)2.07108139
68Abnormality of alanine metabolism (HP:0010916)2.07066202
69Hyperalaninemia (HP:0003348)2.07066202
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07066202
71Acute encephalopathy (HP:0006846)2.07050433
72Methylmalonic aciduria (HP:0012120)2.05198728
73Absent/shortened dynein arms (HP:0200106)12.8091697
74Dynein arm defect of respiratory motile cilia (HP:0012255)12.8091697
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.1584439
76Aplasia/hypoplasia of the uterus (HP:0008684)1.98174117
77Supernumerary spleens (HP:0009799)1.96934297
78Cerebellar dysplasia (HP:0007033)1.96693359
79Ketoacidosis (HP:0001993)1.93979659
80Choroideremia (HP:0001139)1.93809932
81Hypoplasia of the fovea (HP:0007750)1.93647222
82Aplasia/Hypoplasia of the fovea (HP:0008060)1.93647222
83Optic disc pallor (HP:0000543)1.91533404
84Heterotopia (HP:0002282)1.91172811
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.91074257
86Ketosis (HP:0001946)1.90651672
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.90470103
88Focal motor seizures (HP:0011153)1.89074799
89Abnormal urine output (HP:0012590)1.86646477
90Generalized hypopigmentation of hair (HP:0011358)1.86547591
91Male pseudohermaphroditism (HP:0000037)1.85264998
92Severe muscular hypotonia (HP:0006829)1.84999343
93Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83944922
94Intestinal atresia (HP:0011100)1.83637815
95Congenital malformation of the right heart (HP:0011723)1.82817035
96Double outlet right ventricle (HP:0001719)1.82817035
97Dyschromatopsia (HP:0007641)1.82620137
98Postaxial foot polydactyly (HP:0001830)1.81796137
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.81749002
100Abnormal mitochondria in muscle tissue (HP:0008316)1.81054288
101Hypomagnesemia (HP:0002917)1.80415444
102Abnormality of urine glucose concentration (HP:0011016)1.80362943
103Glycosuria (HP:0003076)1.80362943
104Stomatitis (HP:0010280)1.79968349
105Decreased circulating renin level (HP:0003351)1.79139771
106Generalized aminoaciduria (HP:0002909)1.78683484
107Abnormality of vitamin B metabolism (HP:0004340)1.78213780
108Genetic anticipation (HP:0003743)1.77935091
109Asplenia (HP:0001746)1.76376954
110Hypoplasia of the uterus (HP:0000013)1.75587128
111Decreased central vision (HP:0007663)1.70211536
112Congenital hepatic fibrosis (HP:0002612)1.67851448
113Facial cleft (HP:0002006)1.66393792
114Oculomotor apraxia (HP:0000657)1.59421160
115Bundle branch block (HP:0011710)1.58354898
116Short ribs (HP:0000773)1.57589374
117Tubulointerstitial fibrosis (HP:0005576)1.57371138
118Abnormal biliary tract physiology (HP:0012439)1.55428042
119Bile duct proliferation (HP:0001408)1.55428042
120Stage 5 chronic kidney disease (HP:0003774)1.55407284
121Cleft eyelid (HP:0000625)1.51457636
122Abnormality of the lower motor neuron (HP:0002366)1.47690855
123Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.45665705
124Abnormality of the renal cortex (HP:0011035)1.45168870
125Pancreatic fibrosis (HP:0100732)1.42886299
126Pancreatic cysts (HP:0001737)1.38879345
127Hemorrhage of the eye (HP:0011885)1.38674304
128Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.38398526
129Absent epiphyses (HP:0010577)1.38398526
130Abnormal ventriculo-arterial connection (HP:0011563)1.37762705
131Transposition of the great arteries (HP:0001669)1.37762705
132Abnormal connection of the cardiac segments (HP:0011545)1.37762705
133Short humerus (HP:0005792)1.36163460
134Aplasia/hypoplasia of the humerus (HP:0006507)1.36089609
135Postaxial hand polydactyly (HP:0001162)1.36013892
136Sloping forehead (HP:0000340)1.35930939
137Abnormality of abdominal situs (HP:0011620)1.35871797
138Abdominal situs inversus (HP:0003363)1.35871797
139Personality changes (HP:0000751)1.34506987
140Polydipsia (HP:0001959)1.33957181
141Abnormal drinking behavior (HP:0030082)1.33957181
142Amyotrophic lateral sclerosis (HP:0007354)1.33321775
143Cystic liver disease (HP:0006706)1.31036474
144Aplasia/Hypoplasia of the lens (HP:0008063)1.30176402
145Decreased electroretinogram (ERG) amplitude (HP:0000654)1.27779363
146Type 2 muscle fiber atrophy (HP:0003554)1.26296853
147Easy fatigability (HP:0003388)1.26293732
148Abnormality of renal excretion (HP:0011036)1.26201072
149Renal dysplasia (HP:0000110)1.25210037
150Breast hypoplasia (HP:0003187)1.23048136
151Bell-shaped thorax (HP:0001591)1.22813990
152Absent thumb (HP:0009777)1.20124301
153Abnormality of permanent molar morphology (HP:0011071)1.19488100
154Abnormality of the dental root (HP:0006486)1.19488100
155Taurodontia (HP:0000679)1.19488100
156Premature ovarian failure (HP:0008209)1.16831553
157Median cleft lip (HP:0000161)1.16724230
158Optic nerve hypoplasia (HP:0000609)1.15996647
159Aplasia/Hypoplasia of the uvula (HP:0010293)1.15865171
160Congenital primary aphakia (HP:0007707)1.15847342
161True hermaphroditism (HP:0010459)1.15532959
162Difficulty climbing stairs (HP:0003551)1.14689058
163Abnormality of the ileum (HP:0001549)1.14391930
164Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.13316393
165Gait imbalance (HP:0002141)1.13201032
166Meckel diverticulum (HP:0002245)1.12595940
167Fatigable weakness (HP:0003473)1.12145178
168Abnormality of the neuromuscular junction (HP:0003398)1.12145178
169Sensory axonal neuropathy (HP:0003390)1.11484716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.70111785
2PDK47.70111785
3FRK6.32377165
4TESK16.01726284
5PRKD35.02485593
6PDK25.02266961
7ICK4.45761216
8MAP4K23.25784512
9ADRBK22.92789377
10BMPR1B2.80646696
11ZAK2.63800767
12GRK12.53787537
13NEK22.34094299
14TAOK32.15162481
15INSRR2.11532499
16NUAK12.03563759
17MKNK21.86685213
18MAPK131.81061281
19TLK11.77174088
20PNCK1.75809746
21STK381.75166278
22TNIK1.69043807
23TTK1.66578583
24PTK2B1.65257470
25PLK21.55617863
26DYRK1B1.51811657
27WNK41.51592497
28TXK1.46908988
29OXSR11.45893838
30STK391.43035180
31CDC71.40348511
32DYRK31.35438559
33MST41.28772215
34CASK1.26867414
35STK38L1.25266259
36WEE11.20736534
37TAF11.15971818
38BUB11.12080028
39CHEK21.10021624
40PRKCE1.08121318
41PHKG11.06694158
42PHKG21.06694158
43MAP3K41.06428012
44DAPK21.06161828
45PDK11.03063752
46MAPKAPK31.01894648
47TRIM280.98998880
48TEC0.98980909
49CSNK1G20.95629753
50ADRBK10.94443697
51CSNK1G10.93515589
52TESK20.90482137
53PASK0.89817964
54CSNK1G30.88674821
55STK30.87226477
56TGFBR10.86557847
57MKNK10.85791130
58PAK30.84052062
59TYRO30.83463714
60PLK10.80792694
61CCNB10.80767057
62MARK10.79360981
63VRK10.78037069
64IKBKB0.76991934
65PRKCQ0.76109441
66TIE10.74865502
67FGFR20.74706814
68ERBB30.73552996
69FLT30.73509871
70MAPKAPK50.71983671
71BCKDK0.71400497
72BRAF0.70434110
73CHEK10.69999601
74MAPK150.67951682
75PRKCI0.66997739
76ATR0.66257738
77EEF2K0.66193553
78NTRK30.65711736
79ITK0.65422742
80BCR0.63503238
81CDK120.63084794
82PDPK10.61503020
83PLK40.61048604
84CSNK1A1L0.60000825
85PAK10.58779479
86CAMK2A0.55646712
87TNK20.55439073
88PINK10.54167926
89KIT0.53698972
90LATS20.53664069
91MAP2K70.53099161
92ATM0.51957136
93EIF2AK10.51644093
94IRAK10.50968499
95TRPM70.50532347
96BRSK20.48679339
97VRK20.47729899
98PRKG10.47442836
99FER0.47400794
100NME10.45225182
101SRPK10.45194535
102PRKACA0.44445551
103MAP2K60.44400188
104CSNK1A10.43891361
105PAK40.42640316
106SYK0.42190450
107PRKCA0.40409767
108AURKB0.39741434
109PIK3CA0.38883102
110PKN10.38415813
111AURKA0.38085755
112AKT30.37838318
113CAMK2D0.37695509
114BRSK10.37494404
115EPHA20.37442521
116MTOR0.37046370
117NLK0.36534103
118ACVR1B0.36405140
119CDK40.36271918
120WNK10.36224637
121BMPR20.35758500
122STK110.35607481
123IRAK20.35465869
124CAMKK20.34871087
125RPS6KA50.31204314
126LATS10.30583889
127DAPK10.29283205
128CDK70.28959372
129CDK20.28668688
130PLK30.27303074
131WNK30.26529196
132MUSK0.25864441
133CSNK2A10.25388945
134PRKCB0.24884895
135IGF1R0.24482406
136PAK20.23949737
137PRKCG0.23803081
138PRKACB0.23492308
139NTRK20.22959732
140PRKAA10.22300499
141CSNK2A20.22193442
142STK100.21919689
143RIPK40.21692510
144PIM10.21657528
145CDK10.21350293
146MAP3K80.20144231
147MAP3K90.17189340
148CDK150.17121935
149RPS6KB10.16466937
150RPS6KA10.15083940
151CDK60.14454674
152CDK11A0.14132091
153MARK20.13423605
154CDK180.13353426
155CSNK1D0.13096372
156RPS6KA40.12731586
157NEK60.11932945
158GSK3B0.11605562
159LMTK20.10272103
160CSNK1E0.10126425
161CDK140.08589623
162DYRK20.08284896
163MAP3K60.06838789
164PRKDC0.05265444
165MAP3K50.04992680
166PRKCZ0.04697003
167STK160.04348904
168NEK10.03725657
169MST1R0.03666754
170CAMK1G0.02903865
171EIF2AK30.02873936
172CDK30.02854994
173MAP3K100.01772153
174MAPK80.01097055

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.19516859
2Fatty acid biosynthesis_Homo sapiens_hsa000614.00003821
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.67081095
4Basal transcription factors_Homo sapiens_hsa030223.18322020
5Linoleic acid metabolism_Homo sapiens_hsa005912.99242511
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.96543626
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71789262
8Caffeine metabolism_Homo sapiens_hsa002322.71131423
9Phototransduction_Homo sapiens_hsa047442.69107129
10RNA transport_Homo sapiens_hsa030132.62189376
11Pyruvate metabolism_Homo sapiens_hsa006202.50127295
12Fanconi anemia pathway_Homo sapiens_hsa034602.43416330
13DNA replication_Homo sapiens_hsa030302.43131152
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30442256
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.25066479
16Oocyte meiosis_Homo sapiens_hsa041142.19574126
17Butanoate metabolism_Homo sapiens_hsa006502.17945515
18Intestinal immune network for IgA production_Homo sapiens_hsa046722.06331626
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03234148
20Selenocompound metabolism_Homo sapiens_hsa004502.01845086
21Tryptophan metabolism_Homo sapiens_hsa003802.01061011
22Mismatch repair_Homo sapiens_hsa034301.99810280
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99652421
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98313420
25mRNA surveillance pathway_Homo sapiens_hsa030151.95951785
26Nicotine addiction_Homo sapiens_hsa050331.95352026
27Nitrogen metabolism_Homo sapiens_hsa009101.92442221
28Protein export_Homo sapiens_hsa030601.92012258
29Asthma_Homo sapiens_hsa053101.91960240
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89757596
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88287529
32Glucagon signaling pathway_Homo sapiens_hsa049221.86049779
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.77547478
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75976850
35Oxidative phosphorylation_Homo sapiens_hsa001901.75297778
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75138429
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69631004
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.66598604
39Homologous recombination_Homo sapiens_hsa034401.61979401
40Type I diabetes mellitus_Homo sapiens_hsa049401.60951977
41Base excision repair_Homo sapiens_hsa034101.60783146
42Olfactory transduction_Homo sapiens_hsa047401.58267036
43Fructose and mannose metabolism_Homo sapiens_hsa000511.55923540
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53780967
45Propanoate metabolism_Homo sapiens_hsa006401.51400044
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50629042
47Cell cycle_Homo sapiens_hsa041101.50118858
48Pentose phosphate pathway_Homo sapiens_hsa000301.49223676
49Purine metabolism_Homo sapiens_hsa002301.48781755
50Glycerolipid metabolism_Homo sapiens_hsa005611.45292289
51Pyrimidine metabolism_Homo sapiens_hsa002401.43096453
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42469071
53Allograft rejection_Homo sapiens_hsa053301.38451579
54Dorso-ventral axis formation_Homo sapiens_hsa043201.37830929
55Morphine addiction_Homo sapiens_hsa050321.35158154
56Ether lipid metabolism_Homo sapiens_hsa005651.33215903
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.32523166
58Autoimmune thyroid disease_Homo sapiens_hsa053201.32253146
59Parkinsons disease_Homo sapiens_hsa050121.31695229
60Mineral absorption_Homo sapiens_hsa049781.31029087
61Spliceosome_Homo sapiens_hsa030401.26111410
62Nucleotide excision repair_Homo sapiens_hsa034201.26025068
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24477863
64Taste transduction_Homo sapiens_hsa047421.22390961
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.22030654
66Graft-versus-host disease_Homo sapiens_hsa053321.20424294
67Fat digestion and absorption_Homo sapiens_hsa049751.16310301
68Carbon metabolism_Homo sapiens_hsa012001.16119115
69Peroxisome_Homo sapiens_hsa041461.15273365
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11956806
71Glutathione metabolism_Homo sapiens_hsa004801.11650978
72Hedgehog signaling pathway_Homo sapiens_hsa043401.09577403
73Arachidonic acid metabolism_Homo sapiens_hsa005901.05198820
74Primary bile acid biosynthesis_Homo sapiens_hsa001201.05186170
75Huntingtons disease_Homo sapiens_hsa050161.03324848
76Proteasome_Homo sapiens_hsa030501.02541679
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02458502
78RNA degradation_Homo sapiens_hsa030181.02428758
79Non-homologous end-joining_Homo sapiens_hsa034501.00484663
80Regulation of autophagy_Homo sapiens_hsa041400.99930518
81Glutamatergic synapse_Homo sapiens_hsa047240.99352775
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.99078184
83PPAR signaling pathway_Homo sapiens_hsa033200.98611579
84Biosynthesis of amino acids_Homo sapiens_hsa012300.98297627
85Serotonergic synapse_Homo sapiens_hsa047260.97954609
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97409077
87Circadian entrainment_Homo sapiens_hsa047130.94220363
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92774676
89Amphetamine addiction_Homo sapiens_hsa050310.91465945
90Antigen processing and presentation_Homo sapiens_hsa046120.90274789
91Retinol metabolism_Homo sapiens_hsa008300.90095413
92GABAergic synapse_Homo sapiens_hsa047270.90060375
93RNA polymerase_Homo sapiens_hsa030200.88278148
94ABC transporters_Homo sapiens_hsa020100.87563751
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84863681
96Salivary secretion_Homo sapiens_hsa049700.84770451
97Cardiac muscle contraction_Homo sapiens_hsa042600.84485285
98Primary immunodeficiency_Homo sapiens_hsa053400.84202167
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82416069
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.82169416
101Calcium signaling pathway_Homo sapiens_hsa040200.79696325
102Fatty acid metabolism_Homo sapiens_hsa012120.76403918
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74665476
104Fatty acid degradation_Homo sapiens_hsa000710.72841165
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72083577
106Alzheimers disease_Homo sapiens_hsa050100.71669749
107Sulfur metabolism_Homo sapiens_hsa009200.65932735
108Ovarian steroidogenesis_Homo sapiens_hsa049130.65923910
109beta-Alanine metabolism_Homo sapiens_hsa004100.64980803
110Long-term depression_Homo sapiens_hsa047300.64269627
111Systemic lupus erythematosus_Homo sapiens_hsa053220.62808158
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62658746
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60375016
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60332736
115p53 signaling pathway_Homo sapiens_hsa041150.60283739
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.55432685
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54678521
118Estrogen signaling pathway_Homo sapiens_hsa049150.50686987
119Chemical carcinogenesis_Homo sapiens_hsa052040.50305390
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49977323
121Inositol phosphate metabolism_Homo sapiens_hsa005620.49820585
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48291756
123Rheumatoid arthritis_Homo sapiens_hsa053230.47753381
124Legionellosis_Homo sapiens_hsa051340.47432400
125Metabolic pathways_Homo sapiens_hsa011000.44537700
126Thyroid hormone synthesis_Homo sapiens_hsa049180.43886576
127Epstein-Barr virus infection_Homo sapiens_hsa051690.43435818
128Sulfur relay system_Homo sapiens_hsa041220.42823019
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41817875
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40907456
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39525419
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39501156
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39500541
134Histidine metabolism_Homo sapiens_hsa003400.38693731
135Dopaminergic synapse_Homo sapiens_hsa047280.36627042
136Renin-angiotensin system_Homo sapiens_hsa046140.35512776
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.34845917
138Long-term potentiation_Homo sapiens_hsa047200.34712051
139Collecting duct acid secretion_Homo sapiens_hsa049660.34664533
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34227351
141AMPK signaling pathway_Homo sapiens_hsa041520.32430424
142Endocytosis_Homo sapiens_hsa041440.31828701
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31009746
144Renin secretion_Homo sapiens_hsa049240.30872263
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30103445
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27424942
147Viral carcinogenesis_Homo sapiens_hsa052030.26961181
148Alcoholism_Homo sapiens_hsa050340.26837750
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26289784
150One carbon pool by folate_Homo sapiens_hsa006700.26056913
151Basal cell carcinoma_Homo sapiens_hsa052170.25531934
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21697318
153Pancreatic secretion_Homo sapiens_hsa049720.18944967
154Insulin secretion_Homo sapiens_hsa049110.18817967
155Protein digestion and absorption_Homo sapiens_hsa049740.18490155
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18008458
157VEGF signaling pathway_Homo sapiens_hsa043700.17879325
158HIF-1 signaling pathway_Homo sapiens_hsa040660.17158970
159Bile secretion_Homo sapiens_hsa049760.16375055

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