WBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.69391703
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27486024
3neuron cell-cell adhesion (GO:0007158)4.15884882
4ATP synthesis coupled proton transport (GO:0015986)4.03355626
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.03355626
6viral transcription (GO:0019083)3.92687657
7translational termination (GO:0006415)3.86698253
8ribosomal small subunit assembly (GO:0000028)3.75349872
9protein neddylation (GO:0045116)3.74566640
10protein localization to cilium (GO:0061512)3.66823235
11dopamine biosynthetic process (GO:0042416)3.62539781
12behavioral response to nicotine (GO:0035095)3.58432230
13piRNA metabolic process (GO:0034587)3.56808185
14presynaptic membrane assembly (GO:0097105)3.53617682
15GTP biosynthetic process (GO:0006183)3.51341766
16respiratory electron transport chain (GO:0022904)3.50635981
17cotranslational protein targeting to membrane (GO:0006613)3.50568428
18neuronal action potential propagation (GO:0019227)3.48559481
19protein targeting to ER (GO:0045047)3.46895706
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.46069615
21electron transport chain (GO:0022900)3.45699948
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.41249464
23long-chain fatty acid biosynthetic process (GO:0042759)3.40941647
24male meiosis I (GO:0007141)3.40878643
25dopamine transport (GO:0015872)3.40534887
26platelet dense granule organization (GO:0060155)3.39940435
27nonmotile primary cilium assembly (GO:0035058)3.36121881
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33322556
29protein localization to synapse (GO:0035418)3.32598989
30replication fork processing (GO:0031297)3.32271525
31synaptic vesicle exocytosis (GO:0016079)3.30316592
32maturation of SSU-rRNA (GO:0030490)3.29596239
33protein localization to endoplasmic reticulum (GO:0070972)3.27100226
34synapsis (GO:0007129)3.26933134
35otic vesicle formation (GO:0030916)3.25613413
36presynaptic membrane organization (GO:0097090)3.25553479
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.20192166
38resolution of meiotic recombination intermediates (GO:0000712)3.19987568
39neuron fate determination (GO:0048664)3.19303227
40regulation of mitochondrial translation (GO:0070129)3.16821075
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.16621929
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15597114
43ubiquinone biosynthetic process (GO:0006744)3.15014380
44translational elongation (GO:0006414)3.12321316
45chromatin remodeling at centromere (GO:0031055)3.11684313
46respiratory chain complex IV assembly (GO:0008535)3.11469583
47DNA double-strand break processing (GO:0000729)3.10833919
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.10718734
49regulation of dopamine metabolic process (GO:0042053)3.08435609
50regulation of catecholamine metabolic process (GO:0042069)3.08435609
51neuron recognition (GO:0008038)3.04839062
52transmission of nerve impulse (GO:0019226)3.03873221
53glutamate receptor signaling pathway (GO:0007215)3.03324183
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.02743702
55termination of RNA polymerase III transcription (GO:0006386)3.02743702
56startle response (GO:0001964)3.00918873
57axon ensheathment in central nervous system (GO:0032291)2.99706192
58central nervous system myelination (GO:0022010)2.99706192
59protein-cofactor linkage (GO:0018065)2.99094750
60viral life cycle (GO:0019058)2.98883268
61somite development (GO:0061053)2.98506859
62cytochrome complex assembly (GO:0017004)2.98330021
63ubiquinone metabolic process (GO:0006743)2.97423109
64chaperone-mediated protein transport (GO:0072321)2.97030765
65meiosis I (GO:0007127)2.95281089
66UTP biosynthetic process (GO:0006228)2.94550189
67vocalization behavior (GO:0071625)2.94434310
68regulation of vesicle fusion (GO:0031338)2.94304864
69water-soluble vitamin biosynthetic process (GO:0042364)2.93209980
70ATP biosynthetic process (GO:0006754)2.91993224
71intraciliary transport (GO:0042073)2.91679616
72regulation of meiosis I (GO:0060631)2.91298762
73cellular protein complex disassembly (GO:0043624)2.88767844
74synaptic transmission, dopaminergic (GO:0001963)2.86394598
75CENP-A containing nucleosome assembly (GO:0034080)2.86354368
76centriole replication (GO:0007099)2.84946129
77translational initiation (GO:0006413)2.83670764
78positive regulation of synapse assembly (GO:0051965)2.81504657
79detection of calcium ion (GO:0005513)2.81182950
80neuron-neuron synaptic transmission (GO:0007270)2.80672177
81ribosomal small subunit biogenesis (GO:0042274)2.80594809
82regulation of mitotic spindle checkpoint (GO:1903504)2.79610159
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79610159
84protein complex biogenesis (GO:0070271)2.79134341
85establishment of integrated proviral latency (GO:0075713)2.77682290
86pyrimidine nucleobase catabolic process (GO:0006208)2.75606809
87heart process (GO:0003015)2.74150695
88heart contraction (GO:0060047)2.74150695
89proton transport (GO:0015992)2.73938430
90catecholamine transport (GO:0051937)2.73884828
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73074913
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73074913
93kinetochore organization (GO:0051383)2.71726598
94negative regulation of neurotransmitter transport (GO:0051589)2.71469153
95kinetochore assembly (GO:0051382)2.71210206
96translation (GO:0006412)2.69983317
97substrate-independent telencephalic tangential migration (GO:0021826)2.69513012
98substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.69513012
99cell proliferation in forebrain (GO:0021846)2.69161049
100hydrogen transport (GO:0006818)2.68102728
101purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67727422
102regulation of short-term neuronal synaptic plasticity (GO:0048172)2.67215221
103establishment of viral latency (GO:0019043)2.66991208
104mating behavior (GO:0007617)2.66492945
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66014660
106purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65951699
107synaptic transmission, glutamatergic (GO:0035249)2.65189244
108mitochondrial respiratory chain complex I assembly (GO:0032981)2.64759819
109NADH dehydrogenase complex assembly (GO:0010257)2.64759819
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64759819
111protein K6-linked ubiquitination (GO:0085020)2.63295527
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62427501
113epithelial cilium movement (GO:0003351)2.61858048
114regulation of synaptic vesicle exocytosis (GO:2000300)2.61700634
115short-term memory (GO:0007614)2.61472825
116DNA damage response, detection of DNA damage (GO:0042769)2.61288940
117cilium morphogenesis (GO:0060271)2.61166566
118negative regulation of microtubule polymerization (GO:0031115)2.60640266
119regulation of glutamate secretion (GO:0014048)2.60436062
120guanosine-containing compound biosynthetic process (GO:1901070)2.60212729
121positive regulation of cellular response to oxidative stress (GO:1900409)2.59343773
122positive regulation of response to oxidative stress (GO:1902884)2.59343773
123positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59318551
124dendrite development (GO:0016358)2.58576745
125postsynaptic membrane organization (GO:0001941)2.58404978
126pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58347066
127regulation of protein kinase A signaling (GO:0010738)2.57972525
128anterograde synaptic vesicle transport (GO:0048490)2.57172209
129energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.55607803
130ATP hydrolysis coupled proton transport (GO:0015991)2.55607803
131positive regulation of meiosis (GO:0045836)2.55089539
132sequestering of actin monomers (GO:0042989)2.54525948
133nucleoside diphosphate phosphorylation (GO:0006165)2.53880198
134ribonucleoprotein complex disassembly (GO:0032988)2.53840102
135anterograde axon cargo transport (GO:0008089)2.53801619
136cilium movement (GO:0003341)2.52775611
137negative regulation of response to food (GO:0032096)2.52756604
138negative regulation of appetite (GO:0032099)2.52756604
139male meiosis (GO:0007140)2.52507473
140reciprocal DNA recombination (GO:0035825)2.51916535
141reciprocal meiotic recombination (GO:0007131)2.51916535
142mitochondrial respiratory chain complex assembly (GO:0033108)2.51325064
143peptidyl-histidine modification (GO:0018202)2.50967309
144axonal fasciculation (GO:0007413)2.48067747
145organelle disassembly (GO:1903008)2.47323670
146proteasome assembly (GO:0043248)2.47088723
147negative regulation of dendrite morphogenesis (GO:0050774)2.47023321
148DNA methylation involved in gamete generation (GO:0043046)2.45856476
149regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.45046678
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44740601
151glutamate secretion (GO:0014047)2.44702548
152neuronal action potential (GO:0019228)2.44206343
153inner mitochondrial membrane organization (GO:0007007)2.43989773
154histone exchange (GO:0043486)2.43687405
155regulation of feeding behavior (GO:0060259)2.41733215
156hydrogen ion transmembrane transport (GO:1902600)2.41711959
157catecholamine biosynthetic process (GO:0042423)2.41373393
158catechol-containing compound biosynthetic process (GO:0009713)2.41373393
159regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.40393050
160deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.39366027
161regulation of synapse assembly (GO:0051963)2.39233405
162neuromuscular synaptic transmission (GO:0007274)2.38531882
163cilium or flagellum-dependent cell motility (GO:0001539)2.38402659
164synapse assembly (GO:0007416)2.36963055
165negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.36038533
166positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.35090622
167negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.34963164
168substantia nigra development (GO:0021762)2.34829586
169response to amphetamine (GO:0001975)2.34038520
170axonemal dynein complex assembly (GO:0070286)2.31226679
171transferrin transport (GO:0033572)2.28979683
172negative regulation of execution phase of apoptosis (GO:1900118)2.28914666
173regulation of respiratory gaseous exchange (GO:0043576)2.28710636
174dopamine metabolic process (GO:0042417)2.28700603
175positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.28414352
176developmental pigmentation (GO:0048066)2.28396701
177long-term memory (GO:0007616)2.26743379
178regulation of excitatory postsynaptic membrane potential (GO:0060079)2.26168060
179response to pain (GO:0048265)2.25831585
180regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.25772013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.78650869
2GBX2_23144817_ChIP-Seq_PC3_Human3.45351341
3TAF15_26573619_Chip-Seq_HEK293_Human3.37570398
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95018681
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76708279
6VDR_22108803_ChIP-Seq_LS180_Human2.70097159
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67786184
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55238765
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50346704
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32107655
11FUS_26573619_Chip-Seq_HEK293_Human2.31370916
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27256574
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26983880
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15715509
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14954857
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13191083
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11547266
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11406298
19IGF1R_20145208_ChIP-Seq_DFB_Human2.05069381
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01911772
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99590214
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.98976450
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.92381221
24* P300_19829295_ChIP-Seq_ESCs_Human1.90480373
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90238265
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.89994692
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84718619
28MYC_18940864_ChIP-ChIP_HL60_Human1.81069820
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.81014869
30VDR_23849224_ChIP-Seq_CD4+_Human1.77530554
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77456776
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77051977
33REST_21632747_ChIP-Seq_MESCs_Mouse1.74989667
34ER_23166858_ChIP-Seq_MCF-7_Human1.73568725
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69684885
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68117066
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67126148
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.63992116
39RNF2_27304074_Chip-Seq_NSC_Mouse1.63666716
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63513451
41SMAD4_21799915_ChIP-Seq_A2780_Human1.62127662
42* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61889795
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60385871
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59958377
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58940920
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58940920
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58888809
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58657657
49EWS_26573619_Chip-Seq_HEK293_Human1.58540717
50* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58159546
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54955200
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52713099
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51084899
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.48961628
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.47861711
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47175328
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46574056
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45416735
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45278502
60ZNF274_21170338_ChIP-Seq_K562_Hela1.44877686
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.43851908
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.43249450
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43205626
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43025418
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.41836323
66TP53_22573176_ChIP-Seq_HFKS_Human1.40531376
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40283708
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37810198
69JUN_21703547_ChIP-Seq_K562_Human1.37143618
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.36314174
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34818377
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34505441
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32990200
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.31665012
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31271061
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.30478170
77IRF1_19129219_ChIP-ChIP_H3396_Human1.28143460
78FOXP3_21729870_ChIP-Seq_TREG_Human1.28110175
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.25059610
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.23652026
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23567040
82P53_22387025_ChIP-Seq_ESCs_Mouse1.22787360
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.22302859
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.22285036
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.20744492
86* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19964837
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19613980
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18850209
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18657842
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17114539
91P300_18555785_Chip-Seq_ESCs_Mouse1.17065921
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17024244
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16590529
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16203437
95MYC_18555785_ChIP-Seq_MESCs_Mouse1.15295891
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15096834
97CBP_20019798_ChIP-Seq_JUKART_Human1.14789121
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14789121
99* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14714659
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14389835
101AR_21572438_ChIP-Seq_LNCaP_Human1.12637410
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12104356
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12008975
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11680377
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.11310850
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09789993
107* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09415577
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.08582697
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.08488478
110AR_25329375_ChIP-Seq_VCAP_Human1.08178012
111HTT_18923047_ChIP-ChIP_STHdh_Human1.07698620
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06654294
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.06533867
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06274716
115* NANOG_19829295_ChIP-Seq_ESCs_Human1.05840154
116* SOX2_19829295_ChIP-Seq_ESCs_Human1.05840154
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.05539760
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05210133
119RUNX2_22187159_ChIP-Seq_PCA_Human1.05050499
120BCAT_22108803_ChIP-Seq_LS180_Human1.04901045
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.04515399
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.04343191
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03840300
124P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03654101
125TAL1_26923725_Chip-Seq_HPCs_Mouse1.03634312
126IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02112503
127* TCF4_23295773_ChIP-Seq_U87_Human1.01886045
128EZH2_27294783_Chip-Seq_NPCs_Mouse1.01841381
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01454932
130NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00914904
131TP53_18474530_ChIP-ChIP_U2OS_Human1.00347340
132ELK1_19687146_ChIP-ChIP_HELA_Human1.00068837
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99775641
134NCOR_22424771_ChIP-Seq_293T_Human0.98037892
135TTF2_22483619_ChIP-Seq_HELA_Human0.97257370
136THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95998266
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95710654
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95710654
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94514905
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.93803171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.58998534
2MP0004270_analgesia3.05597785
3MP0001188_hyperpigmentation3.01383676
4MP0001968_abnormal_touch/_nociception3.01238340
5MP0006276_abnormal_autonomic_nervous2.99544134
6MP0004859_abnormal_synaptic_plasticity2.92943537
7MP0002736_abnormal_nociception_after2.81909923
8MP0001529_abnormal_vocalization2.76325745
9MP0002735_abnormal_chemical_nociception2.74184071
10MP0003635_abnormal_synaptic_transmissio2.64551895
11MP0003646_muscle_fatigue2.63939425
12MP0001905_abnormal_dopamine_level2.58634688
13MP0009745_abnormal_behavioral_response2.58627939
14MP0002734_abnormal_mechanical_nocicepti2.47171477
15MP0002272_abnormal_nervous_system2.39276631
16MP0002064_seizures2.35278188
17MP0009046_muscle_twitch2.19677332
18MP0008058_abnormal_DNA_repair2.14920441
19MP0002572_abnormal_emotion/affect_behav2.13750680
20MP0002063_abnormal_learning/memory/cond2.12171243
21MP0001486_abnormal_startle_reflex2.11332868
22MP0002938_white_spotting2.07111985
23MP0001440_abnormal_grooming_behavior1.98045112
24MP0000569_abnormal_digit_pigmentation1.97976209
25MP0009379_abnormal_foot_pigmentation1.95251961
26MP0002733_abnormal_thermal_nociception1.94873017
27MP0001970_abnormal_pain_threshold1.93862721
28MP0000778_abnormal_nervous_system1.93377367
29MP0005409_darkened_coat_color1.90336795
30MP0001501_abnormal_sleep_pattern1.88604995
31MP0002067_abnormal_sensory_capabilities1.79588927
32MP0005423_abnormal_somatic_nervous1.78631319
33MP0010386_abnormal_urinary_bladder1.74946481
34MP0002822_catalepsy1.73758547
35MP0002184_abnormal_innervation1.73202487
36MP0003136_yellow_coat_color1.72176685
37MP0005084_abnormal_gallbladder_morpholo1.70604623
38MP0003787_abnormal_imprinting1.66718002
39MP0004742_abnormal_vestibular_system1.65539914
40MP0004147_increased_porphyrin_level1.63815791
41MP0003122_maternal_imprinting1.63419195
42MP0004924_abnormal_behavior1.57165724
43MP0005386_behavior/neurological_phenoty1.57165724
44MP0001293_anophthalmia1.54625952
45MP0004215_abnormal_myocardial_fiber1.48361938
46MP0001986_abnormal_taste_sensitivity1.47725588
47MP0002163_abnormal_gland_morphology1.47713563
48MP0006072_abnormal_retinal_apoptosis1.47641124
49MP0005645_abnormal_hypothalamus_physiol1.47556038
50MP0002638_abnormal_pupillary_reflex1.46581822
51MP0003186_abnormal_redox_activity1.45142515
52MP0005171_absent_coat_pigmentation1.42726882
53MP0003011_delayed_dark_adaptation1.41370787
54MP0008057_abnormal_DNA_replication1.38915738
55MP0008877_abnormal_DNA_methylation1.37007794
56MP0001485_abnormal_pinna_reflex1.36727215
57MP0008995_early_reproductive_senescence1.36668463
58MP0003195_calcinosis1.36567082
59MP0002557_abnormal_social/conspecific_i1.36539657
60MP0001984_abnormal_olfaction1.34323716
61MP0002751_abnormal_autonomic_nervous1.32150234
62MP0004142_abnormal_muscle_tone1.28655015
63MP0003718_maternal_effect1.27337988
64MP0001963_abnormal_hearing_physiology1.25825829
65MP0002210_abnormal_sex_determination1.24382074
66MP0005410_abnormal_fertilization1.23820907
67MP0006036_abnormal_mitochondrial_physio1.22599164
68MP0002882_abnormal_neuron_morphology1.19831660
69MP0004043_abnormal_pH_regulation1.19308388
70MP0002653_abnormal_ependyma_morphology1.19105541
71MP0006292_abnormal_olfactory_placode1.18578247
72MP0004885_abnormal_endolymph1.15484844
73MP0005551_abnormal_eye_electrophysiolog1.14478327
74MP0000955_abnormal_spinal_cord1.13688134
75MP0003890_abnormal_embryonic-extraembry1.12848992
76MP0002102_abnormal_ear_morphology1.12719299
77MP0000631_abnormal_neuroendocrine_gland1.10084891
78MP0002234_abnormal_pharynx_morphology1.09781600
79MP0003121_genomic_imprinting1.09654348
80MP0005379_endocrine/exocrine_gland_phen1.09096357
81MP0002095_abnormal_skin_pigmentation1.08640772
82MP0002066_abnormal_motor_capabilities/c1.07486163
83MP0002752_abnormal_somatic_nervous1.06322400
84MP0005646_abnormal_pituitary_gland1.03482828
85MP0000026_abnormal_inner_ear1.03204795
86MP0005195_abnormal_posterior_eye1.03160282
87MP0002233_abnormal_nose_morphology1.02722227
88MP0000920_abnormal_myelination1.01335486
89MP0000427_abnormal_hair_cycle0.99824592
90MP0005389_reproductive_system_phenotype0.99225209
91MP0003938_abnormal_ear_development0.99179942
92MP0000015_abnormal_ear_pigmentation0.98760795
93MP0002876_abnormal_thyroid_physiology0.98528069
94MP0001502_abnormal_circadian_rhythm0.97581524
95MP0001919_abnormal_reproductive_system0.97553994
96MP0010030_abnormal_orbit_morphology0.97319441
97MP0008569_lethality_at_weaning0.96690252
98MP0004811_abnormal_neuron_physiology0.95573459
99MP0002837_dystrophic_cardiac_calcinosis0.95542167
100MP0001929_abnormal_gametogenesis0.95414906
101MP0006035_abnormal_mitochondrial_morpho0.92237916
102MP0000653_abnormal_sex_gland0.92042494
103MP0000566_synostosis0.90575808
104MP0003123_paternal_imprinting0.89947551
105MP0002229_neurodegeneration0.85537018
106MP0004145_abnormal_muscle_electrophysio0.85453062
107MP0008789_abnormal_olfactory_epithelium0.85056950
108MP0001145_abnormal_male_reproductive0.84177578
109MP0008775_abnormal_heart_ventricle0.83717383
110MP0001286_abnormal_eye_development0.83242877
111MP0005253_abnormal_eye_physiology0.83141585
112MP0002152_abnormal_brain_morphology0.83099086
113MP0002282_abnormal_trachea_morphology0.82799665
114MP0003329_amyloid_beta_deposits0.82291614
115MP0005499_abnormal_olfactory_system0.81840698
116MP0005394_taste/olfaction_phenotype0.81840698
117MP0003137_abnormal_impulse_conducting0.80658632
118MP0003786_premature_aging0.79272432
119MP0001324_abnormal_eye_pigmentation0.78997365
120MP0000049_abnormal_middle_ear0.78145133
121MP0005391_vision/eye_phenotype0.76027596
122MP0008260_abnormal_autophagy0.74733276
123MP0001764_abnormal_homeostasis0.73172550
124MP0002277_abnormal_respiratory_mucosa0.69969263
125MP0005174_abnormal_tail_pigmentation0.69230799
126MP0003634_abnormal_glial_cell0.68731090
127MP0000372_irregular_coat_pigmentation0.68040785
128MP0009250_abnormal_appendicular_skeleto0.66132090
129MP0003631_nervous_system_phenotype0.65718304
130MP0000751_myopathy0.65491176
131MP0003315_abnormal_perineum_morphology0.63499373
132MP0002090_abnormal_vision0.63028611
133MP0008872_abnormal_physiological_respon0.62412423
134MP0002177_abnormal_outer_ear0.61094402
135MP0001664_abnormal_digestion0.61057766
136MP0002160_abnormal_reproductive_system0.60573137
137MP0003698_abnormal_male_reproductive0.60377631
138MP0003861_abnormal_nervous_system0.59654351
139MP0004134_abnormal_chest_morphology0.58457635
140MP0003632_abnormal_nervous_system0.58124673

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.36304624
2Focal motor seizures (HP:0011153)3.88375452
3Progressive macrocephaly (HP:0004481)3.83595366
4Hypothermia (HP:0002045)3.61758705
5Mitochondrial inheritance (HP:0001427)3.60854316
6Abnormal mitochondria in muscle tissue (HP:0008316)3.58694286
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.55830292
8Absent/shortened dynein arms (HP:0200106)3.55830292
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.55819901
10Atonic seizures (HP:0010819)3.53260184
11Medial flaring of the eyebrow (HP:0010747)3.26314743
12Limb dystonia (HP:0002451)3.22176166
13Myokymia (HP:0002411)3.17315239
14Abnormal hair whorl (HP:0010721)3.11923659
15Gait imbalance (HP:0002141)3.07448748
16Hepatic necrosis (HP:0002605)3.06593303
17Cerebral edema (HP:0002181)3.00901877
18Abnormal respiratory epithelium morphology (HP:0012253)2.99452611
19Abnormal respiratory motile cilium morphology (HP:0005938)2.99452611
20Increased CSF lactate (HP:0002490)2.98376947
21Abnormal ciliary motility (HP:0012262)2.96130852
22Optic disc pallor (HP:0000543)2.95681679
23Broad-based gait (HP:0002136)2.90614595
24Acute encephalopathy (HP:0006846)2.88277985
25Congenital primary aphakia (HP:0007707)2.87822408
26Abnormal respiratory motile cilium physiology (HP:0012261)2.86271121
27Increased hepatocellular lipid droplets (HP:0006565)2.85649859
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.84656321
29Abnormality of the renal medulla (HP:0100957)2.84087246
30Febrile seizures (HP:0002373)2.76783432
31Abnormality of the labia minora (HP:0012880)2.72671366
32Focal seizures (HP:0007359)2.72224363
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.70379495
34Increased intramyocellular lipid droplets (HP:0012240)2.63974704
35Genital tract atresia (HP:0001827)2.62269859
36Abnormality of cells of the erythroid lineage (HP:0012130)2.58977558
37Absence seizures (HP:0002121)2.56358415
38Vaginal atresia (HP:0000148)2.56067697
39Nephrogenic diabetes insipidus (HP:0009806)2.54701643
40Progressive cerebellar ataxia (HP:0002073)2.46024988
41Sensory axonal neuropathy (HP:0003390)2.45242131
42Abnormal number of erythroid precursors (HP:0012131)2.40490394
43Septo-optic dysplasia (HP:0100842)2.39284152
44Epileptic encephalopathy (HP:0200134)2.39274541
45Dialeptic seizures (HP:0011146)2.39068716
46Renal Fanconi syndrome (HP:0001994)2.37721567
47Amblyopia (HP:0000646)2.36106945
48Pancreatic fibrosis (HP:0100732)2.35563935
49Molar tooth sign on MRI (HP:0002419)2.35196858
50Abnormality of midbrain morphology (HP:0002418)2.35196858
51Parakeratosis (HP:0001036)2.31268809
52Lactic acidosis (HP:0003128)2.30450408
53Abnormality of the renal cortex (HP:0011035)2.29487431
54Congenital, generalized hypertrichosis (HP:0004540)2.26534986
55Leukodystrophy (HP:0002415)2.24927828
56Reticulocytopenia (HP:0001896)2.24327666
57Hepatocellular necrosis (HP:0001404)2.22866735
58Male pseudohermaphroditism (HP:0000037)2.21856760
59Macrocytic anemia (HP:0001972)2.21645858
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18890417
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18890417
62Rib fusion (HP:0000902)2.18337418
63Increased serum lactate (HP:0002151)2.17986126
64Pendular nystagmus (HP:0012043)2.17859672
65Tubular atrophy (HP:0000092)2.16919582
66True hermaphroditism (HP:0010459)2.15382515
67Autoamputation (HP:0001218)2.15369382
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15300476
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13111948
70Cystic liver disease (HP:0006706)2.11079387
71Rhinitis (HP:0012384)2.10790350
72Poor coordination (HP:0002370)2.10215446
73Anencephaly (HP:0002323)2.09532204
74Progressive inability to walk (HP:0002505)2.07724091
75Colon cancer (HP:0003003)2.07178900
76Lipid accumulation in hepatocytes (HP:0006561)2.06920417
77Hyperglycinemia (HP:0002154)2.06224663
78Retinal dysplasia (HP:0007973)2.05948376
79Nephronophthisis (HP:0000090)2.04636656
80Hyperventilation (HP:0002883)2.03220521
81Aplasia/Hypoplasia of the lens (HP:0008063)2.00803005
82Congenital hepatic fibrosis (HP:0002612)1.99794777
83Glycosuria (HP:0003076)1.99634741
84Abnormality of urine glucose concentration (HP:0011016)1.99634741
85Increased muscle lipid content (HP:0009058)1.99289269
86Methylmalonic acidemia (HP:0002912)1.98732605
87Rimmed vacuoles (HP:0003805)1.98522002
88Congenital stationary night blindness (HP:0007642)1.98272185
89Adrenal hypoplasia (HP:0000835)1.97831148
90Cerebral hypomyelination (HP:0006808)1.97319926
91Respiratory difficulties (HP:0002880)1.97157066
92Supernumerary spleens (HP:0009799)1.95291887
93Absent septum pellucidum (HP:0001331)1.94128416
94Esotropia (HP:0000565)1.93847483
95Postaxial hand polydactyly (HP:0001162)1.93542264
96Anophthalmia (HP:0000528)1.93346991
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93094046
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.93094046
99Postaxial foot polydactyly (HP:0001830)1.92884098
100Delusions (HP:0000746)1.92331778
101Abnormality of the corticospinal tract (HP:0002492)1.90206038
102Visual hallucinations (HP:0002367)1.89253323
103Oligodactyly (hands) (HP:0001180)1.89153048
104Type II lissencephaly (HP:0007260)1.87730645
105Aplasia/Hypoplasia of the uvula (HP:0010293)1.86718950
106Protruding tongue (HP:0010808)1.86608821
107Inability to walk (HP:0002540)1.85996643
108Generalized tonic-clonic seizures (HP:0002069)1.84967750
109Atelectasis (HP:0100750)1.84381184
110Hyperphosphaturia (HP:0003109)1.83731071
111Fetal akinesia sequence (HP:0001989)1.83648843
112Irregular epiphyses (HP:0010582)1.83103968
113Optic nerve hypoplasia (HP:0000609)1.82927027
114Neuroendocrine neoplasm (HP:0100634)1.82849554
115Respiratory failure (HP:0002878)1.81308315
116Median cleft lip (HP:0000161)1.81256128
117Exercise intolerance (HP:0003546)1.80514600
1183-Methylglutaconic aciduria (HP:0003535)1.80408145
119Renal cortical cysts (HP:0000803)1.79585359
120Pheochromocytoma (HP:0002666)1.79576385
121Meckel diverticulum (HP:0002245)1.79527612
122Intestinal atresia (HP:0011100)1.79188010
123Abnormality of the ileum (HP:0001549)1.78840541
124Volvulus (HP:0002580)1.77977395
125Lethargy (HP:0001254)1.77785493
126X-linked dominant inheritance (HP:0001423)1.77727693
127Pancreatic cysts (HP:0001737)1.74999402
128Abnormality of renal resorption (HP:0011038)1.74297040
129Anxiety (HP:0000739)1.73805724
130Metaphyseal dysplasia (HP:0100255)1.73645605
131Stenosis of the external auditory canal (HP:0000402)1.73159720
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72984553
133Abnormality of alanine metabolism (HP:0010916)1.72984553
134Hyperalaninemia (HP:0003348)1.72984553
135Truncal ataxia (HP:0002078)1.72951530
136Exotropia (HP:0000577)1.72402302
137Gaze-evoked nystagmus (HP:0000640)1.72205494
138Abnormality of the septum pellucidum (HP:0007375)1.70603622
139Abnormal drinking behavior (HP:0030082)1.69857305
140Polydipsia (HP:0001959)1.69857305
141Specific learning disability (HP:0001328)1.69473183
142Left ventricular hypertrophy (HP:0001712)1.69455825
143Maternal diabetes (HP:0009800)1.68866728
144Chronic hepatic failure (HP:0100626)1.68177067
145Preaxial hand polydactyly (HP:0001177)1.68089478
146Exertional dyspnea (HP:0002875)1.67650665
147Abnormal autonomic nervous system physiology (HP:0012332)1.66588068
148Aplasia/hypoplasia of the uterus (HP:0008684)1.63447254
149Widely spaced teeth (HP:0000687)1.62476056
150Sclerocornea (HP:0000647)1.62465991
151Peripheral hypomyelination (HP:0007182)1.61809042
152Neurofibrillary tangles (HP:0002185)1.60684837
153Severe visual impairment (HP:0001141)1.58278187
154Aganglionic megacolon (HP:0002251)1.56983856
155Ulnar claw (HP:0001178)1.56942582
156Heterochromia iridis (HP:0001100)1.56940305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.34432379
2PNCK3.15641230
3STK162.85143859
4MAP2K72.74173092
5NTRK32.71752027
6MAP3K122.67928506
7NUAK12.65947204
8STK392.17160795
9MAP4K22.16648880
10NME12.11659829
11TNIK2.08048676
12VRK22.06387702
13PLK22.05289959
14MAP3K41.95295530
15EPHA41.92869884
16OBSCN1.90904127
17CDC71.89637048
18RIPK41.79694520
19BCKDK1.76109203
20BMPR1B1.75954108
21BMPR21.75382872
22ZAK1.72728533
23BCR1.72126290
24GRK71.68134337
25MARK11.68113595
26PINK11.66747638
27ARAF1.65525709
28OXSR11.57133260
29MAPK131.53670080
30FGR1.52446367
31MINK11.51502429
32GRK51.47555879
33TRIM281.42100796
34GRK11.41738100
35CCNB11.38258147
36CDK191.32587801
37STK38L1.32561751
38PBK1.31136626
39EPHB21.29417552
40NEK11.29083621
41ADRBK21.27776382
42NEK61.27626783
43WEE11.24185953
44SRPK11.23844095
45NTRK11.21886396
46MKNK21.21107612
47PHKG21.20742325
48PHKG11.20742325
49CSNK1G31.20050987
50FRK1.19764152
51DYRK31.18673038
52CAMK2B1.18400853
53EIF2AK31.15825143
54PKN11.07538997
55TLK11.06871833
56PLK11.04476335
57UHMK11.04372912
58FES1.04197533
59VRK11.03833644
60CAMK2A1.01950886
61PASK0.99950280
62NTRK20.96281978
63CLK10.96188347
64MKNK10.95347350
65MST40.95184259
66MAPKAPK50.93777324
67SIK30.92077167
68PTK2B0.90842835
69WNK40.87896139
70CSNK1G20.87180704
71DMPK0.85962468
72MUSK0.85480242
73TAF10.84745461
74SIK20.84726639
75BRAF0.84384390
76CAMK2D0.83814697
77CDK50.82859177
78MAP2K40.80525088
79PRKCE0.80347661
80IRAK40.79978152
81ACVR1B0.79846310
82PRKCG0.78869589
83TIE10.78176087
84TAOK30.77763747
85CSNK1A1L0.77105479
86ERBB30.76699723
87PRPF4B0.76425847
88PLK30.76331368
89ADRBK10.73317721
90DYRK20.72796741
91BUB10.72615008
92DYRK1A0.72082020
93PLK40.71563173
94PDK20.71110027
95CSNK1G10.70388612
96CDK140.69949404
97ROCK20.67990391
98STK30.67608817
99PIK3CA0.67384779
100CDK30.67367729
101IRAK10.66940531
102IRAK20.66646635
103TTK0.64124255
104YES10.62885047
105TSSK60.62194269
106CAMK2G0.61572632
107EIF2AK10.59857902
108CDK180.59540369
109RPS6KA50.57369226
110LIMK10.56739220
111PAK30.56540092
112AURKB0.56241905
113CSNK2A20.55820309
114CDK150.54827631
115CDK80.54503784
116PAK60.53675329
117TYRO30.52009198
118CDK11A0.51521840
119AKT30.50660127
120MAP3K90.49823818
121CHEK20.48804235
122SGK4940.48212134
123SGK2230.48212134
124CSNK2A10.47930172
125FER0.45721749
126TGFBR10.44108508
127DAPK10.42911292
128AURKA0.41441453
129PRKACA0.40168191
130ATM0.39653302
131ABL20.39411449
132MAPK150.38451872
133CSNK1E0.35963483
134PRKG10.35697801
135STK110.35442529
136MYLK0.35420073
137BRSK20.34034223
138KSR10.33305904
139WNK30.33006600
140TNK20.32701898
141EIF2AK20.32363026
142CSNK1A10.31926612

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.80915176
2Parkinsons disease_Homo sapiens_hsa050123.16494352
3Nicotine addiction_Homo sapiens_hsa050332.85881935
4Alzheimers disease_Homo sapiens_hsa050102.70274270
5Huntingtons disease_Homo sapiens_hsa050162.46371140
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.34470017
7Collecting duct acid secretion_Homo sapiens_hsa049662.33327650
8Proteasome_Homo sapiens_hsa030502.18503244
9Synaptic vesicle cycle_Homo sapiens_hsa047212.12517885
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97129507
11Serotonergic synapse_Homo sapiens_hsa047261.94846197
12Protein export_Homo sapiens_hsa030601.91353409
13Amphetamine addiction_Homo sapiens_hsa050311.85284457
14Phototransduction_Homo sapiens_hsa047441.82057863
15Olfactory transduction_Homo sapiens_hsa047401.78489611
16Morphine addiction_Homo sapiens_hsa050321.67618036
17Taste transduction_Homo sapiens_hsa047421.67583795
18Long-term potentiation_Homo sapiens_hsa047201.66384626
19Glutamatergic synapse_Homo sapiens_hsa047241.65901088
20Dopaminergic synapse_Homo sapiens_hsa047281.64941949
21Circadian entrainment_Homo sapiens_hsa047131.63625509
22Vibrio cholerae infection_Homo sapiens_hsa051101.63395053
23Ribosome_Homo sapiens_hsa030101.59779533
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58770422
25GABAergic synapse_Homo sapiens_hsa047271.57211812
26Propanoate metabolism_Homo sapiens_hsa006401.57131539
27Cardiac muscle contraction_Homo sapiens_hsa042601.57041093
28Long-term depression_Homo sapiens_hsa047301.48792730
29Cocaine addiction_Homo sapiens_hsa050301.48789028
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48524064
31Folate biosynthesis_Homo sapiens_hsa007901.48043195
32RNA polymerase_Homo sapiens_hsa030201.47108269
33Sulfur relay system_Homo sapiens_hsa041221.43101547
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42864738
35Butanoate metabolism_Homo sapiens_hsa006501.41535372
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28543990
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25727335
38Rheumatoid arthritis_Homo sapiens_hsa053231.23146830
39Renin secretion_Homo sapiens_hsa049241.22997607
40Cholinergic synapse_Homo sapiens_hsa047251.22790284
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22130051
42Tryptophan metabolism_Homo sapiens_hsa003801.15363790
43Caffeine metabolism_Homo sapiens_hsa002321.14982858
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14458352
45Salivary secretion_Homo sapiens_hsa049701.08487461
46Calcium signaling pathway_Homo sapiens_hsa040201.04488749
47RNA transport_Homo sapiens_hsa030131.04380102
48Axon guidance_Homo sapiens_hsa043601.03725168
49Fatty acid elongation_Homo sapiens_hsa000621.03620517
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02390046
51Insulin secretion_Homo sapiens_hsa049111.00982577
52Peroxisome_Homo sapiens_hsa041461.00050620
53Nitrogen metabolism_Homo sapiens_hsa009100.99657822
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.98152852
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.94463753
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92048043
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91693788
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89616356
59Ether lipid metabolism_Homo sapiens_hsa005650.87130688
60Base excision repair_Homo sapiens_hsa034100.86725588
61Phagosome_Homo sapiens_hsa041450.86170799
62Type I diabetes mellitus_Homo sapiens_hsa049400.85842329
63Linoleic acid metabolism_Homo sapiens_hsa005910.85485917
64Non-homologous end-joining_Homo sapiens_hsa034500.85429257
65Alcoholism_Homo sapiens_hsa050340.84050110
66One carbon pool by folate_Homo sapiens_hsa006700.84005920
67Gastric acid secretion_Homo sapiens_hsa049710.83744545
68Oocyte meiosis_Homo sapiens_hsa041140.81460666
69Basal transcription factors_Homo sapiens_hsa030220.79500252
70Gap junction_Homo sapiens_hsa045400.78885077
71African trypanosomiasis_Homo sapiens_hsa051430.76744406
72Oxytocin signaling pathway_Homo sapiens_hsa049210.75725426
73Graft-versus-host disease_Homo sapiens_hsa053320.74215921
74Spliceosome_Homo sapiens_hsa030400.73408879
75beta-Alanine metabolism_Homo sapiens_hsa004100.72479218
76Hedgehog signaling pathway_Homo sapiens_hsa043400.72025889
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70203985
78GnRH signaling pathway_Homo sapiens_hsa049120.69873705
79Nucleotide excision repair_Homo sapiens_hsa034200.69191232
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69185965
81Melanogenesis_Homo sapiens_hsa049160.68974237
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68916664
83Pyruvate metabolism_Homo sapiens_hsa006200.68616048
84Metabolic pathways_Homo sapiens_hsa011000.68393008
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67500117
86Regulation of autophagy_Homo sapiens_hsa041400.67332006
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67103485
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66447192
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66289993
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65990777
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63465269
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.63345982
93cAMP signaling pathway_Homo sapiens_hsa040240.62878459
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62425968
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61775767
96Sphingolipid metabolism_Homo sapiens_hsa006000.58973130
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58794026
98Pyrimidine metabolism_Homo sapiens_hsa002400.57764911
99Selenocompound metabolism_Homo sapiens_hsa004500.57401708
100Purine metabolism_Homo sapiens_hsa002300.56453666
101Arginine and proline metabolism_Homo sapiens_hsa003300.56154747
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52101685
103Estrogen signaling pathway_Homo sapiens_hsa049150.51920000
104Autoimmune thyroid disease_Homo sapiens_hsa053200.51160767
105Basal cell carcinoma_Homo sapiens_hsa052170.50880563
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50797639
107Ras signaling pathway_Homo sapiens_hsa040140.50616846
108Homologous recombination_Homo sapiens_hsa034400.50569764
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50017823
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47977260
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47815223
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.47556969
113Allograft rejection_Homo sapiens_hsa053300.47220639
114Wnt signaling pathway_Homo sapiens_hsa043100.46886555
115RNA degradation_Homo sapiens_hsa030180.45993608
116Cell cycle_Homo sapiens_hsa041100.45968080
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45390841
118Chemical carcinogenesis_Homo sapiens_hsa052040.44540366
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44266715
120Circadian rhythm_Homo sapiens_hsa047100.44203078
121MAPK signaling pathway_Homo sapiens_hsa040100.43903852
122Glutathione metabolism_Homo sapiens_hsa004800.42164178
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41938997
124Fanconi anemia pathway_Homo sapiens_hsa034600.41754655
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.39880367
126ErbB signaling pathway_Homo sapiens_hsa040120.38249885
127Dorso-ventral axis formation_Homo sapiens_hsa043200.35919047
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35673987
129Pancreatic secretion_Homo sapiens_hsa049720.35128634
130Retinol metabolism_Homo sapiens_hsa008300.34721493
131Epstein-Barr virus infection_Homo sapiens_hsa051690.34661065
132Salmonella infection_Homo sapiens_hsa051320.32949412
133Mismatch repair_Homo sapiens_hsa034300.32548695
134Steroid biosynthesis_Homo sapiens_hsa001000.32134529
135mRNA surveillance pathway_Homo sapiens_hsa030150.31863283
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31781826
137Asthma_Homo sapiens_hsa053100.31611665
138Thyroid hormone synthesis_Homo sapiens_hsa049180.30994244
139Sulfur metabolism_Homo sapiens_hsa009200.30627093
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.29972166
141p53 signaling pathway_Homo sapiens_hsa041150.29892034
142Hippo signaling pathway_Homo sapiens_hsa043900.29381684
143Fatty acid degradation_Homo sapiens_hsa000710.28186928
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27374217
145DNA replication_Homo sapiens_hsa030300.26949321
146Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25792273
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22705773
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22546921

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »