WBSCR22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071997.28599137
2negative regulation of cell fate specification (GO:0009996)6.83319299
3negative regulation of norepinephrine secretion (GO:0010700)6.57803519
4neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)6.56109501
5negative regulation of fatty acid transport (GO:2000192)6.24986285
6positive regulation of glomerulus development (GO:0090193)5.70179823
7proteasome assembly (GO:0043248)5.45780530
8extracellular regulation of signal transduction (GO:1900115)5.31242238
9extracellular negative regulation of signal transduction (GO:1900116)5.31242238
10regulation of non-canonical Wnt signaling pathway (GO:2000050)5.19054483
11regulation of icosanoid secretion (GO:0032303)5.01181533
12positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.67187322
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.66541020
14deoxyribonucleotide biosynthetic process (GO:0009263)4.65446629
15negative regulation of heart rate (GO:0010459)4.63045155
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.53845845
17negative regulation of cell fate commitment (GO:0010454)4.42322418
18regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.40834983
19regulation of mesoderm development (GO:2000380)4.40529384
20deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.40226781
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.39489758
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.36073468
23regulation of cellular amino acid metabolic process (GO:0006521)4.30135099
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.29093933
25negative regulation of ligase activity (GO:0051352)4.29093933
26negative regulation of systemic arterial blood pressure (GO:0003085)4.28854819
27regulation of mitochondrial translation (GO:0070129)4.25908941
28regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.23775746
29regulation of cell fate specification (GO:0042659)4.21245193
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.20146276
31exploration behavior (GO:0035640)4.17828227
32mitochondrial DNA replication (GO:0006264)4.15878066
33regulation of mitotic spindle checkpoint (GO:1903504)4.12825919
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.12825919
35regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.12614937
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.10245606
37planar cell polarity pathway involved in neural tube closure (GO:0090179)4.04794640
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.04155599
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.04155599
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.02739634
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.02739634
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.02739634
43response to pheromone (GO:0019236)31.4664329
44rRNA modification (GO:0000154)3.97370297
45dopamine biosynthetic process (GO:0042416)3.97194200
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.94947157
47signal transduction involved in DNA integrity checkpoint (GO:0072401)3.94947157
48regulation of glomerulus development (GO:0090192)3.94287018
49positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.87317317
50signal transduction involved in cell cycle checkpoint (GO:0072395)3.86241304
51regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.83733858
52energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83654526
53ATP synthesis coupled proton transport (GO:0015986)3.83654526
54positive regulation of catenin import into nucleus (GO:0035413)3.78375032
55head development (GO:0060322)3.77343856
56histone H3-K9 methylation (GO:0051567)3.75570366
57negative regulation of catecholamine secretion (GO:0033604)3.72033523
58positive regulation of ligase activity (GO:0051351)3.70624706
59positive regulation of cell cycle checkpoint (GO:1901978)3.70057861
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69223617
61desmosome organization (GO:0002934)3.69180721
62telomere maintenance via semi-conservative replication (GO:0032201)3.67538221
63DNA strand elongation (GO:0022616)3.67198328
64respiratory electron transport chain (GO:0022904)3.65310879
65establishment of protein localization to mitochondrial membrane (GO:0090151)3.64116361
66endocrine hormone secretion (GO:0060986)3.63202522
67positive regulation of nitric-oxide synthase activity (GO:0051000)3.62764197
68ribosome biogenesis (GO:0042254)3.62378997
69establishment of integrated proviral latency (GO:0075713)3.61571340
70electron transport chain (GO:0022900)3.60361810
71formation of translation preinitiation complex (GO:0001731)3.58527743
72chondrocyte development (GO:0002063)3.53565152
73protein maturation by protein folding (GO:0022417)3.49975450
74pseudouridine synthesis (GO:0001522)3.48590468
75metanephric mesenchyme development (GO:0072075)3.48334556
76protein targeting to mitochondrion (GO:0006626)3.47860620
77regulation of ubiquitin-protein transferase activity (GO:0051438)3.47521800
78positive regulation of renal sodium excretion (GO:0035815)3.45899567
79oxidative phosphorylation (GO:0006119)3.45896976
80termination of RNA polymerase III transcription (GO:0006386)3.45630675
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.45630675
82tongue development (GO:0043586)3.45280164
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.44425580
84histone H3-K9 modification (GO:0061647)3.44208711
85positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.40505572
86cellular response to dexamethasone stimulus (GO:0071549)3.37718443
87ribonucleoprotein complex biogenesis (GO:0022613)3.37141297
88regulation of somitogenesis (GO:0014807)3.35806320
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.35491976
90regulation of ligase activity (GO:0051340)3.35184884
91ribosomal large subunit biogenesis (GO:0042273)3.27729853
92mitochondrial RNA metabolic process (GO:0000959)3.27224233
93nucleobase-containing small molecule interconversion (GO:0015949)3.26109125
94rRNA methylation (GO:0031167)3.24375840
95chaperone-mediated protein transport (GO:0072321)3.24232028
96deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23751839
97spliceosomal snRNP assembly (GO:0000387)3.22529467
98hematopoietic stem cell proliferation (GO:0071425)3.22451707
99establishment of protein localization to mitochondrion (GO:0072655)3.21625032
100pteridine-containing compound biosynthetic process (GO:0042559)3.19769960
101positive regulation of metanephros development (GO:0072216)3.19768438
102folic acid-containing compound biosynthetic process (GO:0009396)3.18995588
103cullin deneddylation (GO:0010388)3.17845867
104protein localization to mitochondrion (GO:0070585)3.16783751
105regulation of cellular amine metabolic process (GO:0033238)3.16508392
106establishment of viral latency (GO:0019043)3.16044834
107cellular component biogenesis (GO:0044085)3.15652251
108maturation of SSU-rRNA (GO:0030490)3.14993107
109response to dexamethasone (GO:0071548)3.14775283
110convergent extension (GO:0060026)3.14166841
111positive regulation of cell cycle arrest (GO:0071158)3.14000513
112negative regulation of protein autophosphorylation (GO:0031953)3.13537321
113GDP-mannose metabolic process (GO:0019673)3.12868265
114respiratory chain complex IV assembly (GO:0008535)3.12432528
115protein deneddylation (GO:0000338)3.12312349
116* rRNA processing (GO:0006364)3.11211029
117ribosomal small subunit biogenesis (GO:0042274)3.07953425
118DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.07050178
119mitochondrial DNA metabolic process (GO:0032042)3.05658202
120inner mitochondrial membrane organization (GO:0007007)3.05243564
121transcription-coupled nucleotide-excision repair (GO:0006283)3.04647756
122protein complex biogenesis (GO:0070271)3.04111455
123antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.03738766
124mitochondrial respiratory chain complex assembly (GO:0033108)3.03687644
125translation (GO:0006412)3.02888107
126transcription from mitochondrial promoter (GO:0006390)3.02003309
127tRNA aminoacylation for protein translation (GO:0006418)3.01388935
128peptidyl-histidine modification (GO:0018202)3.00217118
129DNA replication checkpoint (GO:0000076)2.98848863
130kidney mesenchyme development (GO:0072074)2.98727071
131guanosine-containing compound biosynthetic process (GO:1901070)2.98375461
132* rRNA metabolic process (GO:0016072)2.97644707
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97127991
134regulation of norepinephrine secretion (GO:0014061)2.96658063
135telomere maintenance via recombination (GO:0000722)2.96043129
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95598276
137tRNA aminoacylation (GO:0043039)2.95220402
138amino acid activation (GO:0043038)2.95220402
139regulation of spindle checkpoint (GO:0090231)2.94742540
140negative regulation of protein ubiquitination (GO:0031397)2.94412463
141regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.93763785
142mesenchymal cell development (GO:0014031)2.93266186
143viral mRNA export from host cell nucleus (GO:0046784)2.92950507
144cell cycle G1/S phase transition (GO:0044843)2.92779647
145G1/S transition of mitotic cell cycle (GO:0000082)2.92779647
146digestive tract morphogenesis (GO:0048546)2.92494023
147embryonic skeletal joint morphogenesis (GO:0060272)2.89751313
148cytochrome complex assembly (GO:0017004)2.89109521
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86554405
150RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86554405
151GMP metabolic process (GO:0046037)2.85840663
152tricarboxylic acid cycle (GO:0006099)2.84547789
153renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.84326772
154regulation of centrosome cycle (GO:0046605)2.83748282
155SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.83601412
156cell migration involved in heart development (GO:0060973)2.83017729
157negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.82012223
158DNA replication initiation (GO:0006270)2.81959224
159kinetochore organization (GO:0051383)2.81203823
160IMP biosynthetic process (GO:0006188)2.80754170
161positive regulation of mesonephros development (GO:0061213)2.76007007
162kinetochore assembly (GO:0051382)2.75473733
163cell proliferation involved in metanephros development (GO:0072203)2.75014937
164replicative senescence (GO:0090399)2.71643316
165embryonic camera-type eye morphogenesis (GO:0048596)2.70447702
166post-anal tail morphogenesis (GO:0036342)2.70446599
167peptidyl-proline hydroxylation (GO:0019511)2.69063062
168negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.66106564
169establishment of tissue polarity (GO:0007164)2.65958022
170establishment of planar polarity (GO:0001736)2.65958022
171regulation of centrosome duplication (GO:0010824)2.64543217
172ribosome assembly (GO:0042255)2.62120823
173stem cell development (GO:0048864)2.59632537
174pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.59398995
175glomerular filtration (GO:0003094)2.58772653
176epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.54746753
177regulation of gastrulation (GO:0010470)2.54063916
178positive regulation of developmental pigmentation (GO:0048087)2.53990039
179regulation of protein heterodimerization activity (GO:0043497)2.53626875
180Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.53334917
181negative regulation of fibroblast proliferation (GO:0048147)2.52022268
182negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.51171563
183smooth muscle tissue development (GO:0048745)2.49279085
184nucleobase biosynthetic process (GO:0046112)2.49201292
185ribosomal small subunit assembly (GO:0000028)2.48904710
186DNA unwinding involved in DNA replication (GO:0006268)2.48441597
187regulation of establishment of planar polarity (GO:0090175)2.47100516
188regulation of fatty acid transport (GO:2000191)2.45600360
189purine nucleobase biosynthetic process (GO:0009113)2.45593814
190regulation of mesonephros development (GO:0061217)2.45194005
191DNA strand elongation involved in DNA replication (GO:0006271)2.44074664
192cellular sodium ion homeostasis (GO:0006883)2.42529968
193DNA-dependent DNA replication (GO:0006261)2.41527406
194regulation of metanephros development (GO:0072215)2.40067920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41374903
2TP63_19390658_ChIP-ChIP_HaCaT_Human8.24094469
3RBPJ_22232070_ChIP-Seq_NCS_Mouse7.27816772
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.97511661
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.90369053
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.88664508
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.45900726
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.37529634
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24356973
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.24013610
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21440893
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13775211
13IRF1_19129219_ChIP-ChIP_H3396_Human3.10303219
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96034037
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68658851
16DCP1A_22483619_ChIP-Seq_HELA_Human2.68019166
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60687864
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60402262
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.54553619
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.45332122
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38489604
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.34449064
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34232913
24AR_21909140_ChIP-Seq_LNCAP_Human2.32292242
25* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30650822
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28176360
27WT1_19549856_ChIP-ChIP_CCG9911_Human2.25796788
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20212603
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92745561
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.87926282
31KDM5A_27292631_Chip-Seq_BREAST_Human1.83144176
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79354529
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74837743
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.70045678
35FUS_26573619_Chip-Seq_HEK293_Human1.66963394
36* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65813874
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63609611
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63076371
39BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.61657458
40VDR_23849224_ChIP-Seq_CD4+_Human1.61538885
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61185828
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59978279
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59898534
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.59801207
45* XRN2_22483619_ChIP-Seq_HELA_Human1.59268171
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58286868
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53245240
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52059445
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51399058
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51029597
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45493053
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42838341
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42618505
54EWS_26573619_Chip-Seq_HEK293_Human1.40017005
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39981766
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39977346
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.38918709
58ZNF263_19887448_ChIP-Seq_K562_Human1.36933075
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.36733257
60MYC_18940864_ChIP-ChIP_HL60_Human1.36115723
61TTF2_22483619_ChIP-Seq_HELA_Human1.34897346
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.33233490
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32992176
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29581253
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26111341
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25873473
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25004322
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23652336
69TFEB_21752829_ChIP-Seq_HELA_Human1.23419001
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22882720
71SALL4_22934838_ChIP-ChIP_CD34+_Human1.22089278
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.21915593
73ELK1_19687146_ChIP-ChIP_HELA_Human1.20521940
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20380634
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19305114
76FOXP3_21729870_ChIP-Seq_TREG_Human1.18233437
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17906913
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16965840
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14816523
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13646356
81* SRF_21415370_ChIP-Seq_HL-1_Mouse1.13201625
82HTT_18923047_ChIP-ChIP_STHdh_Human1.08636292
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08634156
84MYC_22102868_ChIP-Seq_BL_Human1.08620078
85NANOG_16153702_ChIP-ChIP_HESCs_Human1.06672499
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05517632
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05487406
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02856445
89VDR_21846776_ChIP-Seq_THP-1_Human1.02478136
90SPI1_23547873_ChIP-Seq_NB4_Human1.02088260
91* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02071197
92FOXP1_21924763_ChIP-Seq_HESCs_Human0.99989838
93ELF5_23300383_ChIP-Seq_T47D_Human0.99385211
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99164346
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99054715
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98078976
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97681863
98* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96607512
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96360316
100GABP_19822575_ChIP-Seq_HepG2_Human0.94324350
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94044395
102* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93483683
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92618727
104* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92500505
105SOX2_16153702_ChIP-ChIP_HESCs_Human0.91880189
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91788256
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89575774
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89206843
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87946611
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87928062
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87404687
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86909566
113CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86154019
114ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85696232
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.85450028
116* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85298581
117ELF1_20517297_ChIP-Seq_JURKAT_Human0.82527779
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82269817
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81957439
120HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81774693
121* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81478715
122CIITA_25753668_ChIP-Seq_RAJI_Human0.80238575
123ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.79937464
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79437794
125TP53_16413492_ChIP-PET_HCT116_Human0.79063002
126BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77088203
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77075383
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.76570948
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76044044
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.71111993
131TP53_18474530_ChIP-ChIP_U2OS_Human0.70748936
132SCL_19346495_ChIP-Seq_HPC-7_Human0.70116869
133ZFP57_27257070_Chip-Seq_ESCs_Mouse0.69946488
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.69722181
135SMAD_19615063_ChIP-ChIP_OVARY_Human0.69657534
136CBX2_27304074_Chip-Seq_ESCs_Mouse0.68551803
137SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.68389647
138ELK1_22589737_ChIP-Seq_MCF10A_Human0.68331618
139ERG_20887958_ChIP-Seq_HPC-7_Mouse0.65205058
140MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.65134584
141EZH2_22144423_ChIP-Seq_EOC_Human0.64900965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003121_genomic_imprinting5.84840827
2MP0003806_abnormal_nucleotide_metabolis3.96502995
3MP0002163_abnormal_gland_morphology3.65372843
4MP0003786_premature_aging3.48055430
5MP0006036_abnormal_mitochondrial_physio3.05167250
6MP0002396_abnormal_hematopoietic_system3.04326513
7MP0006292_abnormal_olfactory_placode2.88750513
8MP0003186_abnormal_redox_activity2.78054025
9MP0002938_white_spotting2.73130420
10MP0000372_irregular_coat_pigmentation2.70121544
11MP0000613_abnormal_salivary_gland2.69825975
12MP0005171_absent_coat_pigmentation2.61668593
13MP0009672_abnormal_birth_weight2.60976705
14MP0003718_maternal_effect2.57918704
15MP0003693_abnormal_embryo_hatching2.53985309
16MP0006035_abnormal_mitochondrial_morpho2.42310872
17MP0010030_abnormal_orbit_morphology2.39953361
18MP0001346_abnormal_lacrimal_gland2.39866649
19MP0000566_synostosis2.31061605
20MP0000762_abnormal_tongue_morphology2.18458368
21MP0001293_anophthalmia2.09971793
22MP0000534_abnormal_ureter_morphology2.07463724
23MP0005379_endocrine/exocrine_gland_phen2.01142501
24MP0003122_maternal_imprinting10.0078933
25MP0003111_abnormal_nucleus_morphology1.98147204
26MP0008875_abnormal_xenobiotic_pharmacok1.93184767
27MP0008995_early_reproductive_senescence1.91543709
28MP0009250_abnormal_appendicular_skeleto1.90719222
29MP0009703_decreased_birth_body1.90134325
30MP0010094_abnormal_chromosome_stability1.88929524
31MP0005408_hypopigmentation1.87260007
32MP0008877_abnormal_DNA_methylation1.81473252
33MP0000358_abnormal_cell_content/1.81387261
34MP0003942_abnormal_urinary_system1.80274841
35MP0005220_abnormal_exocrine_pancreas1.79419368
36MP0003385_abnormal_body_wall1.75737646
37MP0001764_abnormal_homeostasis1.74541988
38MP0002210_abnormal_sex_determination1.73557341
39MP0006276_abnormal_autonomic_nervous1.71330030
40MP0001929_abnormal_gametogenesis1.69418959
41MP0003077_abnormal_cell_cycle1.66702837
42MP0000049_abnormal_middle_ear1.65919650
43MP0001661_extended_life_span1.64865474
44MP0001730_embryonic_growth_arrest1.58874880
45MP0002111_abnormal_tail_morphology1.55983500
46MP0004957_abnormal_blastocyst_morpholog1.55396040
47MP0008057_abnormal_DNA_replication1.53529980
48MP0005257_abnormal_intraocular_pressure1.52379983
49MP0003938_abnormal_ear_development1.50545434
50MP0004484_altered_response_of1.48816360
51MP0009697_abnormal_copulation1.47994341
52MP0002277_abnormal_respiratory_mucosa1.42317839
53MP0005075_abnormal_melanosome_morpholog1.40787378
54MP0003937_abnormal_limbs/digits/tail_de1.40239546
55MP0003935_abnormal_craniofacial_develop1.36014649
56MP0003755_abnormal_palate_morphology1.35996012
57MP0001145_abnormal_male_reproductive1.33921261
58MP0002233_abnormal_nose_morphology1.33378909
59MP0002113_abnormal_skeleton_development1.31836713
60MP0005330_cardiomyopathy1.31567705
61MP0002132_abnormal_respiratory_system1.31408882
62MP0000313_abnormal_cell_death1.31400601
63MP0004197_abnormal_fetal_growth/weight/1.30550894
64MP0003868_abnormal_feces_composition1.29078554
65MP0004233_abnormal_muscle_weight1.28521911
66MP0005166_decreased_susceptibility_to1.26801064
67MP0002109_abnormal_limb_morphology1.25663461
68MP0003123_paternal_imprinting1.24184576
69MP0000653_abnormal_sex_gland1.22027265
70MP0002080_prenatal_lethality1.20600835
71MP0000681_abnormal_thyroid_gland1.19052333
72MP0002019_abnormal_tumor_incidence1.18439946
73MP0001881_abnormal_mammary_gland1.15868876
74MP0003698_abnormal_male_reproductive1.15138661
75MP0001853_heart_inflammation1.14702213
76MP0001727_abnormal_embryo_implantation1.12865307
77MP0005275_abnormal_skin_tensile1.12671615
78MP0005503_abnormal_tendon_morphology1.12227081
79MP0008932_abnormal_embryonic_tissue1.11627844
80MP0001697_abnormal_embryo_size1.07156679
81MP0005332_abnormal_amino_acid1.06776018
82MP0003828_pulmonary_edema1.05944883
83MP0001529_abnormal_vocalization1.05909479
84MP0000490_abnormal_crypts_of1.05675819
85MP0002115_abnormal_skeleton_extremities1.04809053
86MP0002932_abnormal_joint_morphology1.03312242
87MP0002160_abnormal_reproductive_system1.03185784
88MP0004147_increased_porphyrin_level1.03146435
89MP0005410_abnormal_fertilization1.01805442
90MP0000343_altered_response_to1.01289538
91MP0002249_abnormal_larynx_morphology0.99555993
92MP0008058_abnormal_DNA_repair0.98396767
93MP0008789_abnormal_olfactory_epithelium0.98112651
94MP0000432_abnormal_head_morphology0.95949152
95MP0000703_abnormal_thymus_morphology0.94255846
96MP0002116_abnormal_craniofacial_bone0.93912301
97MP0005636_abnormal_mineral_homeostasis0.91490272
98MP0003567_abnormal_fetal_cardiomyocyte0.90881677
99MP0009053_abnormal_anal_canal0.89730252
100MP0005670_abnormal_white_adipose0.89386136
101MP0001270_distended_abdomen0.88619769
102MP0005501_abnormal_skin_physiology0.87474983
103MP0002161_abnormal_fertility/fecundity0.85815874
104MP0003941_abnormal_skin_development0.82591203
105MP0000428_abnormal_craniofacial_morphol0.81941822
106MP0010307_abnormal_tumor_latency0.80670151
107MP0005058_abnormal_lysosome_morphology0.80650952
108MP0005451_abnormal_body_composition0.80533776
109MP0004185_abnormal_adipocyte_glucose0.80250685
110MP0000015_abnormal_ear_pigmentation0.80135017
111MP0008438_abnormal_cutaneous_collagen0.78899926
112MP0000733_abnormal_muscle_development0.78641100
113MP0002114_abnormal_axial_skeleton0.78378459
114MP0005645_abnormal_hypothalamus_physiol0.78070078
115MP0004019_abnormal_vitamin_homeostasis0.77868631
116MP0000749_muscle_degeneration0.77375789
117MP0001119_abnormal_female_reproductive0.77277128
118MP0000163_abnormal_cartilage_morphology0.76553296
119MP0002736_abnormal_nociception_after0.76315365
120MP0001286_abnormal_eye_development0.76304370
121MP0005395_other_phenotype0.74485265
122MP0008872_abnormal_physiological_respon0.74439456
123MP0008260_abnormal_autophagy0.74182918
124MP0008007_abnormal_cellular_replicative0.73807561
125MP0002970_abnormal_white_adipose0.73753947
126MP0001175_abnormal_lung_morphology0.73705689
127MP0005389_reproductive_system_phenotype0.72437277
128MP0000427_abnormal_hair_cycle0.71924935
129MP0003699_abnormal_female_reproductive0.71758296
130MP0006072_abnormal_retinal_apoptosis0.70569488
131MP0008961_abnormal_basal_metabolism0.68631376
132MP0002653_abnormal_ependyma_morphology0.68589686
133MP0002877_abnormal_melanocyte_morpholog0.68475371
134MP0002269_muscular_atrophy0.67708644
135MP0005266_abnormal_metabolism0.67230633
136MP0005384_cellular_phenotype0.67075434
137MP0000627_abnormal_mammary_gland0.67045772
138MP0000350_abnormal_cell_proliferation0.66701640
139MP0002095_abnormal_skin_pigmentation0.66608295
140MP0006138_congestive_heart_failure0.66161396
141MP0002088_abnormal_embryonic_growth/wei0.65681364
142MP0005319_abnormal_enzyme/_coenzyme0.65444181
143MP0008873_increased_physiological_sensi0.65353778
144MP0005595_abnormal_vascular_smooth0.63663637
145MP0001905_abnormal_dopamine_level0.63425073
146MP0002751_abnormal_autonomic_nervous0.62808023
147MP0005671_abnormal_response_to0.62737720
148MP0001299_abnormal_eye_distance/0.62660320
149MP0000266_abnormal_heart_morphology0.62199858
150MP0002837_dystrophic_cardiac_calcinosis0.61938871
151MP0002085_abnormal_embryonic_tissue0.61672166
152MP0000678_abnormal_parathyroid_gland0.60475200
153MP0000767_abnormal_smooth_muscle0.59957069
154MP0001919_abnormal_reproductive_system0.59771876
155MP0000647_abnormal_sebaceous_gland0.58452168
156MP0003136_yellow_coat_color0.58407859
157MP0001340_abnormal_eyelid_morphology0.57131884
158MP0005253_abnormal_eye_physiology0.56511290
159MP0003315_abnormal_perineum_morphology0.56069427
160MP0004133_heterotaxia0.56039447
161MP0005083_abnormal_biliary_tract0.55789222
162MP0010352_gastrointestinal_tract_polyps0.55093951
163MP0009333_abnormal_splenocyte_physiolog0.53431703
164MP0002084_abnormal_developmental_patter0.51717369
165MP0002177_abnormal_outer_ear0.50578891
166MP0003795_abnormal_bone_structure0.50086710
167MP0002722_abnormal_immune_system0.50074921
168MP0002925_abnormal_cardiovascular_devel0.49372617
169MP0004808_abnormal_hematopoietic_stem0.48425218
170MP0005380_embryogenesis_phenotype0.48181576
171MP0001672_abnormal_embryogenesis/_devel0.48181576
172MP0002092_abnormal_eye_morphology0.47784237
173MP0003984_embryonic_growth_retardation0.47321044
174MP0001614_abnormal_blood_vessel0.46092554

Predicted human phenotypes

RankGene SetZ-score
1Patchy hypopigmentation of hair (HP:0011365)6.63486373
2Prostate neoplasm (HP:0100787)6.04248350
3Progressive external ophthalmoplegia (HP:0000590)5.91645757
4White forelock (HP:0002211)5.66220536
5Abnormal mitochondria in muscle tissue (HP:0008316)5.14630662
6Acute necrotizing encephalopathy (HP:0006965)5.07563611
7Congenital sensorineural hearing impairment (HP:0008527)5.01186481
8Acute encephalopathy (HP:0006846)4.63393519
9Mitochondrial inheritance (HP:0001427)4.41271673
10Proximal tubulopathy (HP:0000114)4.33632590
11Increased CSF lactate (HP:0002490)4.30250565
12Hepatocellular necrosis (HP:0001404)4.24100332
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.03204247
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.03204247
15Progressive macrocephaly (HP:0004481)4.01198112
16Type I transferrin isoform profile (HP:0003642)3.95489036
17Hepatic necrosis (HP:0002605)3.95316244
18Premature graying of hair (HP:0002216)3.90050438
19Absent eyebrow (HP:0002223)3.88137207
20Flat face (HP:0012368)3.86995753
21Turricephaly (HP:0000262)3.82115651
22Breech presentation (HP:0001623)3.79814321
23Cerebral edema (HP:0002181)3.77317747
24Renal cortical cysts (HP:0000803)3.52169303
25Microvesicular hepatic steatosis (HP:0001414)3.45564781
26Increased serum lactate (HP:0002151)3.42295106
27Abnormality of the prostate (HP:0008775)3.42070693
28Wide cranial sutures (HP:0010537)3.35951946
29Lactic acidosis (HP:0003128)3.35458799
30Increased intramyocellular lipid droplets (HP:0012240)3.28860293
31Rectal prolapse (HP:0002035)3.26299142
32Abnormality of glycolysis (HP:0004366)3.22872737
33Adrenal hypoplasia (HP:0000835)3.21932172
34Testicular atrophy (HP:0000029)3.21930802
35Reticulocytopenia (HP:0001896)3.21917264
36Lipid accumulation in hepatocytes (HP:0006561)3.20638201
37Increased hepatocellular lipid droplets (HP:0006565)3.20423260
38Exercise intolerance (HP:0003546)3.17021855
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.15342505
40Abnormal protein N-linked glycosylation (HP:0012347)3.15342505
41Abnormal protein glycosylation (HP:0012346)3.15342505
42Abnormal glycosylation (HP:0012345)3.15342505
43Supernumerary ribs (HP:0005815)3.13272934
44Cheilitis (HP:0100825)3.13192532
45Supernumerary bones of the axial skeleton (HP:0009144)3.02782476
46Abnormality of the right ventricle (HP:0001707)3.01849346
47Increased muscle lipid content (HP:0009058)3.01419664
48Heterochromia iridis (HP:0001100)3.00682865
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.99133434
50Pulmonary artery stenosis (HP:0004415)2.96833395
51Widely patent fontanelles and sutures (HP:0004492)2.96222930
52Respiratory failure (HP:0002878)2.92355945
53Increased serum pyruvate (HP:0003542)2.92058521
54Abnormal gallbladder physiology (HP:0012438)2.91863464
55Cholecystitis (HP:0001082)2.91863464
56Popliteal pterygium (HP:0009756)2.87259681
57Abnormality of the parietal bone (HP:0002696)2.86773151
58Tracheomalacia (HP:0002779)2.85168067
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.82207621
60Degeneration of anterior horn cells (HP:0002398)2.80471186
61Abnormality of the anterior horn cell (HP:0006802)2.80471186
62Bell-shaped thorax (HP:0001591)2.75768462
63Rhabdomyosarcoma (HP:0002859)2.73662293
64Facial cleft (HP:0002006)2.70590858
65Cleft eyelid (HP:0000625)2.70202706
66Myelomeningocele (HP:0002475)2.67119813
67Abnormal number of erythroid precursors (HP:0012131)2.66801705
68Cerebral hypomyelination (HP:0006808)2.64345496
69Colon cancer (HP:0003003)2.60547498
70Nausea (HP:0002018)2.58527459
71Microretrognathia (HP:0000308)2.58500052
72Renal Fanconi syndrome (HP:0001994)2.57090720
73Lethargy (HP:0001254)2.56214333
74Prolonged neonatal jaundice (HP:0006579)2.55962801
75Progressive muscle weakness (HP:0003323)2.55733835
76Ragged-red muscle fibers (HP:0003200)2.55698014
773-Methylglutaconic aciduria (HP:0003535)2.53739889
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50832835
79Reduced antithrombin III activity (HP:0001976)2.50803153
80Ectopic kidney (HP:0000086)2.50752917
81Abnormality of cells of the erythroid lineage (HP:0012130)2.48638777
82Redundant skin (HP:0001582)2.47445009
83Sparse eyelashes (HP:0000653)2.43726568
84Abnormality of alanine metabolism (HP:0010916)2.42971173
85Hyperalaninemia (HP:0003348)2.42971173
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42971173
87Pancytopenia (HP:0001876)2.40591099
88Absent hair (HP:0002298)2.39982129
89Birth length less than 3rd percentile (HP:0003561)2.38217915
90Long eyelashes (HP:0000527)2.36961279
91Conjugated hyperbilirubinemia (HP:0002908)2.34352294
92Abnormality of the renal collecting system (HP:0004742)2.32962473
93Recurrent cutaneous fungal infections (HP:0011370)2.32114372
94Chronic mucocutaneous candidiasis (HP:0002728)2.32114372
95Microglossia (HP:0000171)2.31980029
96Optic disc pallor (HP:0000543)2.31183445
97Hypokinesia (HP:0002375)2.29706234
98Chromsome breakage (HP:0040012)2.29524251
99Increased nuchal translucency (HP:0010880)2.28175506
100Abnormality of abdominal situs (HP:0011620)2.25735651
101Abdominal situs inversus (HP:0003363)2.25735651
102Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23786367
103Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23424810
104Rough bone trabeculation (HP:0100670)2.23254891
105Leukodystrophy (HP:0002415)2.22613063
106Conical tooth (HP:0000698)2.22053251
107Short tibia (HP:0005736)2.21988933
108Methylmalonic aciduria (HP:0012120)2.21591126
109Coronal craniosynostosis (HP:0004440)2.20236571
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19846805
111Dicarboxylic aciduria (HP:0003215)2.19846805
112Cutaneous finger syndactyly (HP:0010554)2.19088794
113Spastic paraparesis (HP:0002313)2.17654827
114Hyperactive renin-angiotensin system (HP:0000841)2.17276527
115Protruding tongue (HP:0010808)2.15841888
116Facial shape deformation (HP:0011334)2.15814110
117Potter facies (HP:0002009)2.15814110
118CNS demyelination (HP:0007305)2.15773225
119Increased number of teeth (HP:0011069)2.14173212
120Abnormality of methionine metabolism (HP:0010901)2.13512276
121Opisthotonus (HP:0002179)2.12318898
122Short middle phalanx of the 5th finger (HP:0004220)2.08661053
123Respiratory difficulties (HP:0002880)2.08563474
124Macrocytic anemia (HP:0001972)2.07590602
125Emotional lability (HP:0000712)2.05904380
126Oligodontia (HP:0000677)2.05790202
127Lip pit (HP:0100267)2.05509874
128Trismus (HP:0000211)2.05223755
129Patellar aplasia (HP:0006443)2.02116292
130Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00918485
131Short 4th metacarpal (HP:0010044)2.00918485
132Abnormality of the preputium (HP:0100587)2.00811902
133Gout (HP:0001997)1.96863994
134Convex nasal ridge (HP:0000444)1.96040328
135Abnormal number of incisors (HP:0011064)1.95664433
136Generalized aminoaciduria (HP:0002909)1.95144607
137Tented upper lip vermilion (HP:0010804)1.94158577
138Fibular hypoplasia (HP:0003038)1.94103335
139Premature ovarian failure (HP:0008209)1.93953388
140Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93927524
141Vertebral compression fractures (HP:0002953)1.93866743
142Cutaneous syndactyly (HP:0012725)1.88261948
143Chronic diarrhea (HP:0002028)1.88204234
144Aplasia cutis congenita (HP:0001057)1.88030043
145Methylmalonic acidemia (HP:0002912)1.87622852
146Limited elbow extension (HP:0001377)1.86793696
147Secondary amenorrhea (HP:0000869)1.85330673
148Rhabdomyolysis (HP:0003201)1.85234534
149Aplastic anemia (HP:0001915)1.82932975
150Progressive microcephaly (HP:0000253)1.81967760
151Aplasia/Hypoplasia of the patella (HP:0006498)1.81032395
152Breast hypoplasia (HP:0003187)1.80750214
153Duplicated collecting system (HP:0000081)1.80643516
154Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79214296
155Large eyes (HP:0001090)1.79210300
156Abnormality of sulfur amino acid metabolism (HP:0004339)1.79171079
157Spinal cord lesions (HP:0100561)1.78339350
158Syringomyelia (HP:0003396)1.78339350
159Atresia of the external auditory canal (HP:0000413)1.77681208
160Abnormality of the renal cortex (HP:0011035)1.77194246
161Synophrys (HP:0000664)1.76632073
162CNS hypomyelination (HP:0003429)1.76555197
163External ophthalmoplegia (HP:0000544)1.76436779
164Renal dysplasia (HP:0000110)1.75939018
165Narrow nasal bridge (HP:0000446)1.74285273
166Delayed cranial suture closure (HP:0000270)1.73740918
167Unilateral renal agenesis (HP:0000122)1.73713581
168Abnormality of pyrimidine metabolism (HP:0004353)1.73580204
169Pallor (HP:0000980)1.73328434
170Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72940596
171Horseshoe kidney (HP:0000085)1.72596635
172Hyperammonemia (HP:0001987)1.71910399
173Tracheoesophageal fistula (HP:0002575)1.71556806
174Multiple enchondromatosis (HP:0005701)1.70889189
175Recurrent pneumonia (HP:0006532)1.70647584
176Renal duplication (HP:0000075)1.70053346
177Abnormality of serum amino acid levels (HP:0003112)1.69685772
178Progressive neurologic deterioration (HP:0002344)1.69592063
179Abnormality of male internal genitalia (HP:0000022)1.69351713
180Ependymoma (HP:0002888)1.67686375
181Meckel diverticulum (HP:0002245)1.66229237
182Hypergonadotropic hypogonadism (HP:0000815)1.66118932
183Abnormal respiratory epithelium morphology (HP:0012253)1.65453517
184Abnormal respiratory motile cilium morphology (HP:0005938)1.65453517
185Metabolic acidosis (HP:0001942)1.63268728
186Entropion (HP:0000621)1.63230849
187Postnatal microcephaly (HP:0005484)1.62885912
188Abnormality of placental membranes (HP:0011409)1.62707025
189Amniotic constriction ring (HP:0009775)1.62707025
190Cutaneous melanoma (HP:0012056)1.62533205
191Vomiting (HP:0002013)1.61694512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK85.82054683
2VRK24.34114765
3BUB14.20868006
4RPS6KA43.83439848
5CDC73.18560666
6PBK3.10961652
7SIK33.06854730
8MST42.97844923
9ZAK2.81255398
10NME12.69449832
11MAP3K132.60610948
12PDK22.58124865
13EIF2AK12.57274754
14BCKDK2.49337571
15CDK72.42246950
16WEE12.33932544
17EPHA22.21768912
18EIF2AK22.02118296
19NME22.02076743
20CHEK21.99377388
21MST1R1.91155339
22SRPK11.89936684
23VRK11.82373762
24PLK41.76098649
25KDR1.74941759
26TESK11.71610790
27ATR1.69903193
28MAPKAPK31.67972298
29MAPK111.67952203
30TXK1.52161812
31MAP4K11.49232318
32SIK11.48114394
33MAP3K121.46291851
34LIMK11.43285104
35INSRR1.42603000
36TEC1.39889428
37TTK1.35367282
38SIK21.31941163
39MKNK11.29307371
40PRKCI1.29118070
41EIF2AK31.25013014
42CDK121.24692602
43SMG11.22979485
44TESK21.22681565
45MAP3K141.22132337
46BRSK21.19365313
47IRAK31.18973249
48NEK21.17828915
49MARK31.17824594
50STK101.14145402
51PLK11.12900872
52PLK31.12708354
53TSSK61.10236204
54DAPK11.05827346
55CAMK1D1.03698916
56AKT21.01508052
57CSNK1G30.95338917
58AURKB0.92607092
59WNK10.91389806
60NUAK10.90521011
61PAK40.89267429
62CSNK1A1L0.88559146
63RPS6KA50.86230902
64BRSK10.85943152
65CCNB10.85779293
66MAP3K80.85755492
67IRAK40.85473799
68FGFR10.84660873
69CSNK2A10.84427007
70TRIM280.81446137
71MUSK0.80848932
72ATM0.79668699
73RPS6KB20.77696708
74CSNK2A20.76556100
75MKNK20.76332974
76BLK0.74837967
77MAP4K20.74334509
78CSNK1G10.73828906
79TGFBR10.73483765
80CAMK10.72624308
81TGFBR20.71026869
82STK160.70741604
83TLK10.69884713
84CDK30.68520330
85PASK0.65577290
86LRRK20.65219564
87YES10.64570760
88ACVR1B0.63435198
89AKT30.61551928
90IKBKB0.61020750
91CHEK10.60381473
92MET0.59247656
93PIM10.59137010
94ZAP700.57989890
95CLK10.57684288
96PHKG10.57226510
97PHKG20.57226510
98MAPKAPK50.56088496
99BRD40.55804173
100LYN0.55778066
101NEK10.55701586
102ILK0.55576641
103PRKAA20.54784644
104CAMK1G0.54754371
105MAPK150.53046481
106ERBB40.52903662
107NEK60.52311488
108PRKCQ0.51434299
109TIE10.51380425
110KIT0.51261898
111MAP2K20.50399526
112ALK0.50182353
113PAK10.50133563
114PIM20.49457448
115LMTK20.48394271
116SCYL20.46025569
117STK40.44649878
118MAP3K30.44647799
119CDK20.43786231
120AURKA0.42989535
121DYRK20.42170699
122CDK10.40260298
123SYK0.40009495
124CSNK1G20.39912836
125FLT30.39451828
126BTK0.38839240
127ITK0.38725102
128CDK40.38198503
129ABL20.38172971
130FER0.36185934
131DYRK30.35509882
132MAPK130.35266579
133CSF1R0.34587156
134CSNK1D0.34108208
135ARAF0.30967182
136CSNK1E0.30068032
137PAK20.29945752
138PNCK0.29879155
139LCK0.28618441
140CAMK2G0.28567846
141TYK20.28379583
142MAPKAPK20.25254180
143TAOK20.22061288
144TBK10.21461567

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046144.77509689
2DNA replication_Homo sapiens_hsa030304.46708878
3Homologous recombination_Homo sapiens_hsa034403.98109142
4Mismatch repair_Homo sapiens_hsa034303.53357177
5Ribosome_Homo sapiens_hsa030103.33122133
6Oxidative phosphorylation_Homo sapiens_hsa001902.95645558
7Spliceosome_Homo sapiens_hsa030402.88471394
8Pyrimidine metabolism_Homo sapiens_hsa002402.76047012
9Proteasome_Homo sapiens_hsa030502.72104901
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66251461
11Parkinsons disease_Homo sapiens_hsa050122.57303528
12Fanconi anemia pathway_Homo sapiens_hsa034602.54863769
13Cell cycle_Homo sapiens_hsa041102.51352146
14One carbon pool by folate_Homo sapiens_hsa006702.47025909
15RNA polymerase_Homo sapiens_hsa030202.44737756
16Base excision repair_Homo sapiens_hsa034102.32822852
17RNA transport_Homo sapiens_hsa030132.32813812
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.32466804
19p53 signaling pathway_Homo sapiens_hsa041152.14362981
20Huntingtons disease_Homo sapiens_hsa050162.04370623
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93051330
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80398391
23Nucleotide excision repair_Homo sapiens_hsa034201.73648966
24Fatty acid elongation_Homo sapiens_hsa000621.71784845
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.58965232
26Basal transcription factors_Homo sapiens_hsa030221.58439609
27Folate biosynthesis_Homo sapiens_hsa007901.56209859
28Alzheimers disease_Homo sapiens_hsa050101.54655476
29Herpes simplex infection_Homo sapiens_hsa051681.50791032
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.49851868
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45983993
32Carbon metabolism_Homo sapiens_hsa012001.34333794
33Glutathione metabolism_Homo sapiens_hsa004801.28418803
34Pyruvate metabolism_Homo sapiens_hsa006201.28266431
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25859261
36Primary immunodeficiency_Homo sapiens_hsa053401.23252939
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23040510
38Purine metabolism_Homo sapiens_hsa002301.21621202
39Sulfur metabolism_Homo sapiens_hsa009201.15875927
40Non-homologous end-joining_Homo sapiens_hsa034501.13506682
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11599422
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08505340
43RNA degradation_Homo sapiens_hsa030181.06095467
44Fructose and mannose metabolism_Homo sapiens_hsa000511.05397543
45MicroRNAs in cancer_Homo sapiens_hsa052061.02940855
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02196537
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99920354
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99328018
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97899772
50Propanoate metabolism_Homo sapiens_hsa006400.96891453
51Vitamin B6 metabolism_Homo sapiens_hsa007500.95816794
52Epstein-Barr virus infection_Homo sapiens_hsa051690.94488012
53HTLV-I infection_Homo sapiens_hsa051660.94214887
54Arginine and proline metabolism_Homo sapiens_hsa003300.92610274
55Hematopoietic cell lineage_Homo sapiens_hsa046400.85878293
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.84568701
57Small cell lung cancer_Homo sapiens_hsa052220.83783868
58Metabolic pathways_Homo sapiens_hsa011000.82641798
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78033860
60Wnt signaling pathway_Homo sapiens_hsa043100.76619021
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75637908
62Melanoma_Homo sapiens_hsa052180.72544986
63Prostate cancer_Homo sapiens_hsa052150.72412997
64Acute myeloid leukemia_Homo sapiens_hsa052210.71662907
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.71039073
66Cardiac muscle contraction_Homo sapiens_hsa042600.69710837
67Collecting duct acid secretion_Homo sapiens_hsa049660.69674328
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.66323738
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65885953
70Vibrio cholerae infection_Homo sapiens_hsa051100.65873898
71Phenylalanine metabolism_Homo sapiens_hsa003600.65298999
72Peroxisome_Homo sapiens_hsa041460.64423568
73Tyrosine metabolism_Homo sapiens_hsa003500.63605205
74N-Glycan biosynthesis_Homo sapiens_hsa005100.63521115
75Systemic lupus erythematosus_Homo sapiens_hsa053220.62057113
76Measles_Homo sapiens_hsa051620.62050925
77Sulfur relay system_Homo sapiens_hsa041220.61102021
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.60922067
79Basal cell carcinoma_Homo sapiens_hsa052170.59986907
80mRNA surveillance pathway_Homo sapiens_hsa030150.59549664
81Selenocompound metabolism_Homo sapiens_hsa004500.58777710
82Galactose metabolism_Homo sapiens_hsa000520.58309390
83Fatty acid metabolism_Homo sapiens_hsa012120.56360459
84Arginine biosynthesis_Homo sapiens_hsa002200.51334011
85Chronic myeloid leukemia_Homo sapiens_hsa052200.50885769
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50436551
87Hepatitis B_Homo sapiens_hsa051610.49408187
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48301397
89Antigen processing and presentation_Homo sapiens_hsa046120.48032785
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47721947
91Viral carcinogenesis_Homo sapiens_hsa052030.44560818
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44514474
93B cell receptor signaling pathway_Homo sapiens_hsa046620.44339465
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44092882
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43892705
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43794359
97Oocyte meiosis_Homo sapiens_hsa041140.43067960
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42487985
99Pathways in cancer_Homo sapiens_hsa052000.41428970
100Pentose phosphate pathway_Homo sapiens_hsa000300.40558764
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40339008
102Butanoate metabolism_Homo sapiens_hsa006500.39069974
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38937308
104Steroid biosynthesis_Homo sapiens_hsa001000.38569905
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38078763
106Influenza A_Homo sapiens_hsa051640.37227277
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37065684
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37049898
109beta-Alanine metabolism_Homo sapiens_hsa004100.36549388
110Regulation of autophagy_Homo sapiens_hsa041400.36406351
111Pancreatic cancer_Homo sapiens_hsa052120.35023856
112Apoptosis_Homo sapiens_hsa042100.34200111
113Mineral absorption_Homo sapiens_hsa049780.32357763
114Bladder cancer_Homo sapiens_hsa052190.32315913
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.31513651
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31413820
117Biosynthesis of amino acids_Homo sapiens_hsa012300.31248680
118Chemical carcinogenesis_Homo sapiens_hsa052040.30752114
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28840241
120Hippo signaling pathway_Homo sapiens_hsa043900.27773099
121HIF-1 signaling pathway_Homo sapiens_hsa040660.26891569
122Fatty acid degradation_Homo sapiens_hsa000710.26838693
123Leishmaniasis_Homo sapiens_hsa051400.25661063
124Adherens junction_Homo sapiens_hsa045200.25638160
125Colorectal cancer_Homo sapiens_hsa052100.25307871
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25249161
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24956369
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24300165
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24209262
130T cell receptor signaling pathway_Homo sapiens_hsa046600.23921088
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23694016
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23463578
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23150179
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.23136337
135Protein export_Homo sapiens_hsa030600.23018705
136Other glycan degradation_Homo sapiens_hsa005110.22415972
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21283393
138Non-small cell lung cancer_Homo sapiens_hsa052230.21096095
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18247130
140Shigellosis_Homo sapiens_hsa051310.18122430
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18008714
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17852705
143Notch signaling pathway_Homo sapiens_hsa043300.17623323
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17041427
145Tryptophan metabolism_Homo sapiens_hsa003800.16867731
146Vitamin digestion and absorption_Homo sapiens_hsa049770.16770843
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14455248
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14204616
149Primary bile acid biosynthesis_Homo sapiens_hsa001200.11057573
150Legionellosis_Homo sapiens_hsa051340.10592435
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.09658713
152Lysosome_Homo sapiens_hsa041420.06435773

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