WDCP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)6.03449111
2DNA strand elongation involved in DNA replication (GO:0006271)4.80153022
3nuclear pore complex assembly (GO:0051292)4.79749318
4mitotic metaphase plate congression (GO:0007080)4.75601410
5DNA strand elongation (GO:0022616)4.58941639
6DNA unwinding involved in DNA replication (GO:0006268)4.57671813
7nuclear pore organization (GO:0006999)4.47516920
8protein localization to kinetochore (GO:0034501)4.41559949
9metaphase plate congression (GO:0051310)4.33875158
10protein localization to chromosome, centromeric region (GO:0071459)4.22958915
11mitotic chromosome condensation (GO:0007076)4.20429480
12sister chromatid segregation (GO:0000819)4.19147199
13mitotic sister chromatid segregation (GO:0000070)4.15542256
14telomere maintenance via semi-conservative replication (GO:0032201)4.14347479
15mitotic spindle checkpoint (GO:0071174)4.13235730
16spindle checkpoint (GO:0031577)4.13058680
17mitotic nuclear envelope disassembly (GO:0007077)4.07632103
18DNA topological change (GO:0006265)4.07396623
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.04428534
20chromatin remodeling at centromere (GO:0031055)4.03596047
21negative regulation of chromosome segregation (GO:0051985)3.95634965
22negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.93627257
23negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.93627257
24negative regulation of mitotic sister chromatid segregation (GO:0033048)3.93627257
25negative regulation of mitotic sister chromatid separation (GO:2000816)3.93627257
26negative regulation of sister chromatid segregation (GO:0033046)3.93627257
27double-strand break repair via nonhomologous end joining (GO:0006303)3.92335487
28non-recombinational repair (GO:0000726)3.92335487
29CENP-A containing nucleosome assembly (GO:0034080)3.91804488
30establishment of integrated proviral latency (GO:0075713)3.88952421
31DNA replication checkpoint (GO:0000076)3.81205104
32membrane disassembly (GO:0030397)3.80695616
33nuclear envelope disassembly (GO:0051081)3.80695616
34mitotic spindle assembly checkpoint (GO:0007094)3.79940421
35mitotic sister chromatid cohesion (GO:0007064)3.78219688
36spindle assembly checkpoint (GO:0071173)3.74825999
37establishment of chromosome localization (GO:0051303)3.74484508
38mitotic recombination (GO:0006312)3.68407668
39regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.67575930
40regulation of mitotic metaphase/anaphase transition (GO:0030071)3.67575930
41DNA ligation (GO:0006266)3.67066439
42proteasome assembly (GO:0043248)3.65972172
43regulation of chromosome segregation (GO:0051983)3.63357284
44DNA replication initiation (GO:0006270)3.62937416
45regulation of sister chromatid segregation (GO:0033045)3.62822020
46regulation of mitotic sister chromatid separation (GO:0010965)3.62822020
47regulation of mitotic sister chromatid segregation (GO:0033047)3.62822020
48telomere maintenance via recombination (GO:0000722)3.56354199
49pore complex assembly (GO:0046931)3.54684806
50peptidyl-lysine dimethylation (GO:0018027)3.50868778
51somatic diversification of immune receptors via somatic mutation (GO:0002566)3.50277685
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.50277685
53kinetochore organization (GO:0051383)3.47655509
54DNA duplex unwinding (GO:0032508)3.46182575
55DNA geometric change (GO:0032392)3.44067439
56DNA replication-independent nucleosome organization (GO:0034724)3.43599865
57DNA replication-independent nucleosome assembly (GO:0006336)3.43599865
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.38915308
59regulation of double-strand break repair via homologous recombination (GO:0010569)3.37917218
60IMP biosynthetic process (GO:0006188)3.34659254
61regulation of helicase activity (GO:0051095)3.34567788
62histone exchange (GO:0043486)3.29516479
63nucleobase biosynthetic process (GO:0046112)3.23898923
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23100369
65negative regulation of mitosis (GO:0045839)3.16127714
66DNA replication-dependent nucleosome organization (GO:0034723)3.15810202
67DNA replication-dependent nucleosome assembly (GO:0006335)3.15810202
68negative regulation of DNA recombination (GO:0045910)3.12334448
69regulation of centrosome cycle (GO:0046605)3.11964025
70purine nucleobase biosynthetic process (GO:0009113)3.10820632
71kinetochore assembly (GO:0051382)3.08417308
72regulation of RNA export from nucleus (GO:0046831)3.07823040
73chromosome segregation (GO:0007059)3.05834943
74attachment of spindle microtubules to kinetochore (GO:0008608)3.03453149
75regulation of centriole replication (GO:0046599)3.02229504
76positive regulation of chromosome segregation (GO:0051984)3.01593987
77telomere maintenance via telomere lengthening (GO:0010833)3.00321277
78regulation of DNA endoreduplication (GO:0032875)2.99670392
79DNA conformation change (GO:0071103)2.98397122
80establishment of viral latency (GO:0019043)2.96340365
81regulation of translational fidelity (GO:0006450)2.96150321
82ribosome assembly (GO:0042255)2.96125224
83DNA damage response, detection of DNA damage (GO:0042769)2.94926882
84protein localization to chromosome (GO:0034502)2.92934990
85heterochromatin organization (GO:0070828)2.92833664
86IMP metabolic process (GO:0046040)2.91924731
87protein complex localization (GO:0031503)2.90957754
88nuclear envelope organization (GO:0006998)2.88855051
89pre-miRNA processing (GO:0031054)2.86170597
90DNA double-strand break processing (GO:0000729)2.84082163
91chromatin assembly or disassembly (GO:0006333)2.83986010
92base-excision repair (GO:0006284)2.80370731
93negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.80010301
94cellular protein complex localization (GO:0034629)2.79262494
95ATP-dependent chromatin remodeling (GO:0043044)2.78345083
96establishment of protein localization to mitochondrial membrane (GO:0090151)2.75198877
97negative regulation of nuclear division (GO:0051784)2.74977804
98ribosomal small subunit assembly (GO:0000028)2.74917712
99mitochondrial RNA metabolic process (GO:0000959)2.73839632
100meiotic chromosome segregation (GO:0045132)2.73600349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.49537846
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.32711729
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75854313
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.62825588
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.38199936
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.91436188
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83842308
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.79562276
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.72436266
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.67507909
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67112194
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.66540855
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58368834
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50480434
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46298841
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.45334577
17AR_21909140_ChIP-Seq_LNCAP_Human2.40854468
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40702094
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27098843
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.24456418
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22656227
22ELK1_19687146_ChIP-ChIP_HELA_Human2.22373073
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21802881
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18752834
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12122034
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10584080
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04701148
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03548952
29E2F7_22180533_ChIP-Seq_HELA_Human10.6791181
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99740670
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97550040
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96729280
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93240599
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87880059
35TTF2_22483619_ChIP-Seq_HELA_Human1.86655956
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80449659
37FOXP3_21729870_ChIP-Seq_TREG_Human1.77742897
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77247274
39XRN2_22483619_ChIP-Seq_HELA_Human1.72967095
40DCP1A_22483619_ChIP-Seq_HELA_Human1.69703727
41VDR_23849224_ChIP-Seq_CD4+_Human1.69152599
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68999756
43GABP_19822575_ChIP-Seq_HepG2_Human1.63655869
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61750142
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60490111
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58709242
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54239072
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51116410
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50205506
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.46741531
51IGF1R_20145208_ChIP-Seq_DFB_Human1.45504362
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42876282
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33944570
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30640812
55E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29981799
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29318448
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.29173703
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.29138623
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28922522
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26700045
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.26497403
62MYC_18940864_ChIP-ChIP_HL60_Human1.25555057
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.23069352
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22166081
65KDM5A_27292631_Chip-Seq_BREAST_Human1.17709978
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17158142
67EWS_26573619_Chip-Seq_HEK293_Human1.08525936
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06885187
69SOX17_20123909_ChIP-Seq_XEN_Mouse1.02597930
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02353451
71CIITA_25753668_ChIP-Seq_RAJI_Human0.97226819
72ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97146838
73FUS_26573619_Chip-Seq_HEK293_Human0.97111507
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96006310
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94637942
76ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92313991
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91581606
78SRF_21415370_ChIP-Seq_HL-1_Mouse0.89675787
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88407897
80ZNF274_21170338_ChIP-Seq_K562_Hela0.84825660
81IRF1_19129219_ChIP-ChIP_H3396_Human0.84342467
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84112478
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82103627
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79088641
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77171434
86NANOG_21062744_ChIP-ChIP_HESCs_Human0.76640729
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75988141
88TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73272897
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72528604
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72499927
91GATA1_26923725_Chip-Seq_HPCs_Mouse0.71343252
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.70816464
93TFEB_21752829_ChIP-Seq_HELA_Human0.69071495
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.68755393
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.66851223
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.66851223
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.66851223
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.66610632
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.64614754
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.64058348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.56748003
2MP0003111_abnormal_nucleus_morphology4.28253588
3MP0003693_abnormal_embryo_hatching4.09658953
4MP0008058_abnormal_DNA_repair3.65350676
5MP0004957_abnormal_blastocyst_morpholog3.27886403
6MP0006292_abnormal_olfactory_placode3.24758084
7MP0003077_abnormal_cell_cycle3.22591200
8MP0008057_abnormal_DNA_replication3.16952244
9MP0002102_abnormal_ear_morphology2.95696668
10MP0008932_abnormal_embryonic_tissue2.77014066
11MP0003718_maternal_effect2.61538998
12MP0005377_hearing/vestibular/ear_phenot2.42042473
13MP0003878_abnormal_ear_physiology2.42042473
14MP0008789_abnormal_olfactory_epithelium2.31870461
15MP0008007_abnormal_cellular_replicative2.20991468
16MP0005499_abnormal_olfactory_system2.01356462
17MP0005394_taste/olfaction_phenotype2.01356462
18MP0001730_embryonic_growth_arrest1.94923378
19MP0003121_genomic_imprinting1.93887051
20MP0008877_abnormal_DNA_methylation1.88289309
21MP0009697_abnormal_copulation1.86821684
22MP0010030_abnormal_orbit_morphology1.81800253
23MP0003937_abnormal_limbs/digits/tail_de1.80612151
24MP0000350_abnormal_cell_proliferation1.78065511
25MP0001293_anophthalmia1.73525022
26MP0003122_maternal_imprinting1.63979082
27MP0003890_abnormal_embryonic-extraembry1.63843417
28MP0003941_abnormal_skin_development1.58055792
29MP0003786_premature_aging1.54527179
30MP0001672_abnormal_embryogenesis/_devel1.54194072
31MP0005380_embryogenesis_phenotype1.54194072
32MP0002085_abnormal_embryonic_tissue1.46958721
33MP0010307_abnormal_tumor_latency1.46387465
34MP0002084_abnormal_developmental_patter1.45825315
35MP0003567_abnormal_fetal_cardiomyocyte1.43279417
36MP0001286_abnormal_eye_development1.40893077
37MP0004233_abnormal_muscle_weight1.38641859
38MP0001697_abnormal_embryo_size1.38163107
39MP0009672_abnormal_birth_weight1.35460005
40MP0003136_yellow_coat_color1.29272791
41MP0002233_abnormal_nose_morphology1.28878660
42MP0002697_abnormal_eye_size1.27420698
43MP0003123_paternal_imprinting1.26786138
44MP0002088_abnormal_embryonic_growth/wei1.25450351
45MP0003984_embryonic_growth_retardation1.25283559
46MP0002080_prenatal_lethality1.25062972
47MP0002210_abnormal_sex_determination1.20223677
48MP0004197_abnormal_fetal_growth/weight/1.19083673
49MP0001929_abnormal_gametogenesis1.17998300
50MP0000049_abnormal_middle_ear1.17749999
51MP0003385_abnormal_body_wall1.15727454
52MP0006072_abnormal_retinal_apoptosis1.12678881
53MP0003861_abnormal_nervous_system1.11187360
54MP0003221_abnormal_cardiomyocyte_apopto1.10646207
55MP0008995_early_reproductive_senescence1.09423760
56MP0002938_white_spotting1.06126600
57MP0003315_abnormal_perineum_morphology1.04880708
58MP0001119_abnormal_female_reproductive1.03857653
59MP0005187_abnormal_penis_morphology1.02867336
60MP0000313_abnormal_cell_death1.02660833
61MP0003755_abnormal_palate_morphology1.01583135
62MP0002751_abnormal_autonomic_nervous1.00248406
63MP0000778_abnormal_nervous_system0.97623731
64MP0000653_abnormal_sex_gland0.96886056
65MP0009703_decreased_birth_body0.96531900
66MP0001145_abnormal_male_reproductive0.94376456
67MP0003119_abnormal_digestive_system0.94268945
68MP0002086_abnormal_extraembryonic_tissu0.92938155
69MP0002092_abnormal_eye_morphology0.92510114
70MP0006035_abnormal_mitochondrial_morpho0.91912663
71MP0002111_abnormal_tail_morphology0.91719673
72MP0001485_abnormal_pinna_reflex0.91393902
73MP0001529_abnormal_vocalization0.90587868
74MP0000566_synostosis0.89020236
75MP0000647_abnormal_sebaceous_gland0.87238068
76MP0001299_abnormal_eye_distance/0.86401542
77MP0002234_abnormal_pharynx_morphology0.85620127
78MP0005623_abnormal_meninges_morphology0.85354903
79MP0005391_vision/eye_phenotype0.83408512
80MP0000428_abnormal_craniofacial_morphol0.83291187
81MP0000631_abnormal_neuroendocrine_gland0.80284087
82MP0001984_abnormal_olfaction0.79154574
83MP0002396_abnormal_hematopoietic_system0.78493826
84MP0004133_heterotaxia0.77268358
85MP0003935_abnormal_craniofacial_develop0.77076604
86MP0001661_extended_life_span0.76963430
87MP0000358_abnormal_cell_content/0.76590923
88MP0003699_abnormal_female_reproductive0.74676590
89MP0002161_abnormal_fertility/fecundity0.74529367
90MP0003646_muscle_fatigue0.74298569
91MP0003698_abnormal_male_reproductive0.73764679
92MP0009053_abnormal_anal_canal0.68643649
93MP0005253_abnormal_eye_physiology0.67777817
94MP0002160_abnormal_reproductive_system0.66714834
95MP0010352_gastrointestinal_tract_polyps0.66620580
96MP0005395_other_phenotype0.66566332
97MP0003942_abnormal_urinary_system0.65854251
98MP0009250_abnormal_appendicular_skeleto0.65540369
99MP0000537_abnormal_urethra_morphology0.64498009
100MP0001346_abnormal_lacrimal_gland0.62604426

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.65241605
2Chromsome breakage (HP:0040012)4.48551004
3Esophageal atresia (HP:0002032)3.32678960
4Birth length less than 3rd percentile (HP:0003561)3.30545274
5Abnormality of the labia minora (HP:0012880)3.23982879
6Cortical dysplasia (HP:0002539)3.18469026
7Meckel diverticulum (HP:0002245)3.13679446
8Colon cancer (HP:0003003)3.12757420
9Abnormal lung lobation (HP:0002101)3.05182549
10Shawl scrotum (HP:0000049)2.99500505
11Abnormality of the ileum (HP:0001549)2.97972547
12Abnormality of chromosome stability (HP:0003220)2.89978884
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.88015770
14Chronic otitis media (HP:0000389)2.71572970
15Multiple enchondromatosis (HP:0005701)2.70939518
16Abnormality of the preputium (HP:0100587)2.65957183
17Agnosia (HP:0010524)2.64054655
18Muscle fiber atrophy (HP:0100295)2.59447384
19Increased nuchal translucency (HP:0010880)2.55806789
20Reticulocytopenia (HP:0001896)2.54985817
21Medulloblastoma (HP:0002885)2.53803980
22Proximal placement of thumb (HP:0009623)2.50794804
23Patellar aplasia (HP:0006443)2.49594993
24Volvulus (HP:0002580)2.49257242
25Overlapping toe (HP:0001845)2.47363970
26Nephroblastoma (Wilms tumor) (HP:0002667)2.46504242
27Small intestinal stenosis (HP:0012848)2.38475747
28Duodenal stenosis (HP:0100867)2.38475747
29Ependymoma (HP:0002888)2.37738893
30Large earlobe (HP:0009748)2.34514432
31Gastrointestinal atresia (HP:0002589)2.31130233
32Horseshoe kidney (HP:0000085)2.30553248
33Septo-optic dysplasia (HP:0100842)2.29758262
34Embryonal renal neoplasm (HP:0011794)2.29511435
35Deviation of the thumb (HP:0009603)2.27224537
36Supernumerary spleens (HP:0009799)2.25538206
37Midline defect of the nose (HP:0004122)2.21646524
38Bifid tongue (HP:0010297)2.21509044
39Aplasia/Hypoplasia of the patella (HP:0006498)2.21048443
40Abnormality of the duodenum (HP:0002246)2.20406157
41Trigonocephaly (HP:0000243)2.19392399
42Neoplasm of the adrenal cortex (HP:0100641)2.18368130
43Clubbing of toes (HP:0100760)2.16875387
44Preaxial hand polydactyly (HP:0001177)2.15938512
45Rhabdomyosarcoma (HP:0002859)2.15067481
46Abnormality of the antihelix (HP:0009738)2.14734534
47Abnormality of the carotid arteries (HP:0005344)2.13795383
48Hemivertebrae (HP:0002937)2.13026254
49Trismus (HP:0000211)2.11403381
50Sloping forehead (HP:0000340)2.10134025
51Ectopic kidney (HP:0000086)2.10104897
52Increased serum pyruvate (HP:0003542)2.09906449
53Choanal atresia (HP:0000453)2.08805579
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.04796134
55Triphalangeal thumb (HP:0001199)2.02999206
56Oligodactyly (hands) (HP:0001180)2.01767248
57Abnormality of chromosome segregation (HP:0002916)2.00828408
58Absent radius (HP:0003974)1.99976692
59Facial cleft (HP:0002006)1.96479600
60Oligodactyly (HP:0012165)1.93729740
61Deep philtrum (HP:0002002)1.93475337
62Abnormality of glycolysis (HP:0004366)1.91850150
63Respiratory difficulties (HP:0002880)1.90543347
64Absent forearm bone (HP:0003953)1.90470335
65Aplasia involving forearm bones (HP:0009822)1.90470335
66Atresia of the external auditory canal (HP:0000413)1.89598865
67Poikiloderma (HP:0001029)1.86029066
68Abnormality of the metopic suture (HP:0005556)1.85918333
69Abnormality of DNA repair (HP:0003254)1.85743284
70Abnormality of the astrocytes (HP:0100707)1.85386001
71Astrocytoma (HP:0009592)1.85386001
72Hypoplastic pelvis (HP:0008839)1.85235395
73High anterior hairline (HP:0009890)1.81072717
74Duplication of thumb phalanx (HP:0009942)1.80072036
75Facial hemangioma (HP:0000329)1.79293054
76Myelodysplasia (HP:0002863)1.78517538
77Preauricular skin tag (HP:0000384)1.77679922
78Chronic sinusitis (HP:0011109)1.77667045
79Abnormality of cochlea (HP:0000375)1.77492602
80Abnormal number of incisors (HP:0011064)1.76569251
81Prominent metopic ridge (HP:0005487)1.74829527
82Microvesicular hepatic steatosis (HP:0001414)1.73714559
83Large eyes (HP:0001090)1.73034280
84Capillary hemangiomas (HP:0005306)1.72150392
85Progressive inability to walk (HP:0002505)1.72144586
86Glioma (HP:0009733)1.69119193
87Growth hormone deficiency (HP:0000824)1.68228297
88Neoplasm of the colon (HP:0100273)1.67876605
89Short tibia (HP:0005736)1.66953545
90Hepatoblastoma (HP:0002884)1.65153752
91Small hand (HP:0200055)1.65106513
92Rib fusion (HP:0000902)1.61440416
93Squamous cell carcinoma (HP:0002860)1.60867125
94Morphological abnormality of the inner ear (HP:0011390)1.59961003
95Tracheoesophageal fistula (HP:0002575)1.59058572
96Cellular immunodeficiency (HP:0005374)1.59031341
97Flat capital femoral epiphysis (HP:0003370)1.57116418
98Short thumb (HP:0009778)1.56824502
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55246849
100Achilles tendon contracture (HP:0001771)1.53559791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.91271493
2CDC73.58318854
3TSSK63.49233563
4SRPK13.30082702
5TTK3.10193531
6BRSK22.77695949
7NEK12.48695243
8PLK32.45198876
9WEE12.39947616
10PLK42.37877728
11PLK12.05285244
12TRIM282.03014105
13MKNK21.98226446
14MKNK11.93898667
15MAP3K101.93571946
16PBK1.90835189
17CHEK21.88333305
18TGFBR21.81777450
19WNK31.80776486
20ZAK1.79167587
21BRD41.77292429
22CCNB11.75606120
23BRSK11.70736070
24NUAK11.69612120
25MOS1.58712490
26ATR1.52253704
27EIF2AK11.47932818
28STK101.46391007
29EIF2AK31.44474878
30LATS11.40366175
31CHEK11.34895818
32BCR1.27851715
33MAP3K41.26933670
34TAF11.26152958
35ERBB31.26015438
36AURKA1.22509205
37CDK71.22475543
38AURKB1.19768446
39EIF2AK21.19556780
40GRK71.16332708
41CSNK1G11.15057398
42ATM1.14875748
43VRK11.07164908
44VRK21.06161455
45TNIK0.99166097
46DYRK20.97650681
47CSNK1G30.95873911
48MAP2K70.94364152
49CSNK1A1L0.85790201
50NEK20.85137925
51INSRR0.83392174
52NME10.80926471
53CDK20.79676372
54CDK10.77883496
55CSNK1G20.76475878
56CDK120.75849311
57CASK0.74997201
58CLK10.74825535
59PLK20.73526092
60CDK40.72998384
61PASK0.72651126
62CDK190.71436225
63YES10.71020839
64PIM10.69223156
65PRKDC0.69074449
66CDK80.65863353
67DYRK30.65559915
68BMPR1B0.64591976
69PNCK0.60173094
70RAF10.59961733
71STK30.56811642
72MAP3K80.54040651
73ERBB40.52429077
74RPS6KA40.52258944
75CSNK1E0.52175880
76FLT30.51941076
77CSNK2A20.51792657
78CDK90.50631302
79CAMK1D0.49832631
80CSNK2A10.49280662
81CDK30.46935618
82CDK60.46238353
83CSNK1D0.43878375
84FGFR10.42915601
85CAMK1G0.42680254
86EEF2K0.41951710
87CDK140.41815543
88RPS6KB20.40351814
89STK40.38975681
90NEK60.38885497
91NME20.38761880
92BRAF0.37597174
93CDK180.37250295
94KSR10.36015801
95STK160.35309152
96PTK20.35119861
97ALK0.33851106
98CDK150.33462571
99RPS6KB10.33173179
100CDK11A0.32734272

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.36229327
2Mismatch repair_Homo sapiens_hsa034304.31923974
3Non-homologous end-joining_Homo sapiens_hsa034503.45749806
4Cell cycle_Homo sapiens_hsa041103.11885252
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95002270
6Base excision repair_Homo sapiens_hsa034102.94570664
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86991570
8Fanconi anemia pathway_Homo sapiens_hsa034602.69879000
9Homologous recombination_Homo sapiens_hsa034402.68683344
10Spliceosome_Homo sapiens_hsa030402.64114902
11Nucleotide excision repair_Homo sapiens_hsa034202.52481680
12Proteasome_Homo sapiens_hsa030502.45106575
13RNA transport_Homo sapiens_hsa030132.44300196
14Basal transcription factors_Homo sapiens_hsa030222.25828952
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18970149
16Steroid biosynthesis_Homo sapiens_hsa001002.16179444
17RNA polymerase_Homo sapiens_hsa030202.06250182
18RNA degradation_Homo sapiens_hsa030181.75417954
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.72837562
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67881420
21mRNA surveillance pathway_Homo sapiens_hsa030151.64324667
22Pyrimidine metabolism_Homo sapiens_hsa002401.64035392
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56129805
24Biosynthesis of amino acids_Homo sapiens_hsa012301.55078318
25One carbon pool by folate_Homo sapiens_hsa006701.53841413
26Ribosome_Homo sapiens_hsa030101.38509487
27Protein export_Homo sapiens_hsa030601.38344930
28p53 signaling pathway_Homo sapiens_hsa041151.35605145
29Propanoate metabolism_Homo sapiens_hsa006401.34415106
30Oocyte meiosis_Homo sapiens_hsa041141.31882953
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25016645
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24750399
33Selenocompound metabolism_Homo sapiens_hsa004501.20011090
34Pyruvate metabolism_Homo sapiens_hsa006201.19479639
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15790587
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09649286
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05724609
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03661994
39Carbon metabolism_Homo sapiens_hsa012001.02529818
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01416275
41Purine metabolism_Homo sapiens_hsa002300.97808505
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96573987
43Lysine degradation_Homo sapiens_hsa003100.95372997
44Vitamin B6 metabolism_Homo sapiens_hsa007500.93376353
45Fatty acid elongation_Homo sapiens_hsa000620.90505106
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89971242
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88049457
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87071845
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77729751
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72608080
51N-Glycan biosynthesis_Homo sapiens_hsa005100.68467816
52Fatty acid metabolism_Homo sapiens_hsa012120.65454467
53Hippo signaling pathway_Homo sapiens_hsa043900.63927192
54MicroRNAs in cancer_Homo sapiens_hsa052060.62654821
55Basal cell carcinoma_Homo sapiens_hsa052170.61087856
56Arginine and proline metabolism_Homo sapiens_hsa003300.61055617
57Colorectal cancer_Homo sapiens_hsa052100.59752233
58Folate biosynthesis_Homo sapiens_hsa007900.55688182
59Butanoate metabolism_Homo sapiens_hsa006500.54795698
60Systemic lupus erythematosus_Homo sapiens_hsa053220.53347543
61Huntingtons disease_Homo sapiens_hsa050160.53277647
62Adherens junction_Homo sapiens_hsa045200.53056735
63Hedgehog signaling pathway_Homo sapiens_hsa043400.52224135
64Alcoholism_Homo sapiens_hsa050340.50522049
65Wnt signaling pathway_Homo sapiens_hsa043100.48228999
66Viral carcinogenesis_Homo sapiens_hsa052030.47780580
67Epstein-Barr virus infection_Homo sapiens_hsa051690.46890210
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43803910
69Thyroid cancer_Homo sapiens_hsa052160.40958632
70Metabolic pathways_Homo sapiens_hsa011000.40810947
71beta-Alanine metabolism_Homo sapiens_hsa004100.40739950
72TGF-beta signaling pathway_Homo sapiens_hsa043500.40721747
73Fatty acid biosynthesis_Homo sapiens_hsa000610.38022514
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37932617
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.37674028
76Fatty acid degradation_Homo sapiens_hsa000710.35885009
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34281172
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31977590
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31248778
80Pentose phosphate pathway_Homo sapiens_hsa000300.28479197
81Parkinsons disease_Homo sapiens_hsa050120.28122320
82Sulfur relay system_Homo sapiens_hsa041220.26699130
83Prostate cancer_Homo sapiens_hsa052150.26232863
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25990294
85Bladder cancer_Homo sapiens_hsa052190.24529033
86Melanoma_Homo sapiens_hsa052180.24250346
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21414078
88Herpes simplex infection_Homo sapiens_hsa051680.20881453
89Arginine biosynthesis_Homo sapiens_hsa002200.17516054
90Peroxisome_Homo sapiens_hsa041460.17309204
91Chronic myeloid leukemia_Homo sapiens_hsa052200.15413413
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14536094
93Regulation of autophagy_Homo sapiens_hsa041400.13900593
94Glutathione metabolism_Homo sapiens_hsa004800.13072018
95Inositol phosphate metabolism_Homo sapiens_hsa005620.12204198
96Tight junction_Homo sapiens_hsa045300.11544426
97ABC transporters_Homo sapiens_hsa020100.10764836
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10341874
99HTLV-I infection_Homo sapiens_hsa051660.10135631
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.09846539

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