WDFY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.87047267
2axon ensheathment in central nervous system (GO:0032291)6.87047267
3presynaptic membrane assembly (GO:0097105)5.19562955
4regulation of pigment cell differentiation (GO:0050932)4.79445614
5paraxial mesoderm development (GO:0048339)4.78194613
6nuclear pore complex assembly (GO:0051292)4.74853092
7presynaptic membrane organization (GO:0097090)4.73820648
8regulation of histone H3-K9 methylation (GO:0051570)4.56463202
9limb bud formation (GO:0060174)4.43670154
10nuclear pore organization (GO:0006999)4.41407778
11long-chain fatty acid biosynthetic process (GO:0042759)4.40792473
12negative regulation of execution phase of apoptosis (GO:1900118)4.31694432
13myelination (GO:0042552)4.12142361
14axon ensheathment (GO:0008366)4.06435311
15ensheathment of neurons (GO:0007272)4.06435311
16developmental pigmentation (GO:0048066)4.00181816
17epithelial cilium movement (GO:0003351)3.99995703
18nucleotide transmembrane transport (GO:1901679)3.95612049
19neuron cell-cell adhesion (GO:0007158)3.90013957
20axonemal dynein complex assembly (GO:0070286)3.77218527
21cerebral cortex radially oriented cell migration (GO:0021799)3.72597154
22fatty acid elongation (GO:0030497)3.69737662
23cellular protein complex localization (GO:0034629)3.61148321
24pre-miRNA processing (GO:0031054)3.59217229
25negative regulation of histone methylation (GO:0031061)3.58683661
26regulation of DNA methylation (GO:0044030)3.58491081
27cilium movement (GO:0003341)3.58473877
28pore complex assembly (GO:0046931)3.57174577
29melanin biosynthetic process (GO:0042438)3.56490658
30melanin metabolic process (GO:0006582)3.56450038
31acrosome reaction (GO:0007340)3.55574249
32oligodendrocyte differentiation (GO:0048709)3.52287372
33mitotic sister chromatid cohesion (GO:0007064)3.50811682
34GPI anchor biosynthetic process (GO:0006506)3.38956736
35negative regulation of DNA repair (GO:0045738)3.34387330
36preassembly of GPI anchor in ER membrane (GO:0016254)3.33842514
37regulation of collateral sprouting (GO:0048670)3.32337918
38eye photoreceptor cell differentiation (GO:0001754)3.30786307
39photoreceptor cell differentiation (GO:0046530)3.30786307
40sperm motility (GO:0030317)3.29915589
41mannosylation (GO:0097502)3.28400361
42negative regulation of neurotransmitter secretion (GO:0046929)3.26315957
43monoubiquitinated protein deubiquitination (GO:0035520)3.22810017
44multicellular organism reproduction (GO:0032504)3.22507267
45protein localization to kinetochore (GO:0034501)3.22193316
46intraciliary transport (GO:0042073)3.20022335
47postsynaptic membrane organization (GO:0001941)3.19166996
48magnesium ion transport (GO:0015693)3.16166901
49GTP biosynthetic process (GO:0006183)3.15256309
50regulation of mitotic spindle organization (GO:0060236)3.13703279
51substrate-dependent cell migration (GO:0006929)3.13610821
52protein complex localization (GO:0031503)3.12624441
53mitotic chromosome condensation (GO:0007076)3.10773806
54GPI anchor metabolic process (GO:0006505)3.10179981
55ribosome assembly (GO:0042255)3.09744204
56positive regulation of oligodendrocyte differentiation (GO:0048714)3.04485409
57glycerophospholipid catabolic process (GO:0046475)3.03969802
58histone H3-K9 demethylation (GO:0033169)3.03753664
59negative regulation of transcription by competitive promoter binding (GO:0010944)3.03571296
60lymphoid progenitor cell differentiation (GO:0002320)3.03267121
61cell adhesion mediated by integrin (GO:0033627)3.02817603
62fusion of sperm to egg plasma membrane (GO:0007342)3.00466460
63response to redox state (GO:0051775)3.00282238
64positive regulation of SMAD protein import into nucleus (GO:0060391)2.99951046
65pinocytosis (GO:0006907)2.99454426
66protein neddylation (GO:0045116)2.97896529
67negative regulation of neurotransmitter transport (GO:0051589)2.97427681
68secondary metabolite biosynthetic process (GO:0044550)2.96746261
69COPII vesicle coating (GO:0048208)2.96135575
70protein localization to chromosome, centromeric region (GO:0071459)2.96014552
71cranial nerve development (GO:0021545)2.94069426
72keratinocyte development (GO:0003334)2.90824471
73dopamine biosynthetic process (GO:0042416)2.88602904
74regulation of spindle organization (GO:0090224)2.86659185
75isoprenoid biosynthetic process (GO:0008299)2.86651632
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85325185
77negative regulation of fibroblast apoptotic process (GO:2000270)2.84601159
78microtubule polymerization or depolymerization (GO:0031109)2.84021166
79embryonic process involved in female pregnancy (GO:0060136)2.83577832
80establishment of chromosome localization (GO:0051303)2.83557441
81nonmotile primary cilium assembly (GO:0035058)2.82616787
82regulation of RNA export from nucleus (GO:0046831)2.82220140
83positive regulation of cell size (GO:0045793)2.82072129
84cholesterol biosynthetic process (GO:0006695)2.81917416
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81129893
86positive regulation of action potential (GO:0045760)2.78954024
87histone H2B ubiquitination (GO:0033523)2.75950793
88ear development (GO:0043583)2.70881861
89otic vesicle formation (GO:0030916)2.69942353
90spinal cord motor neuron differentiation (GO:0021522)2.69311842
91positive regulation of mitotic sister chromatid separation (GO:1901970)2.69048217
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.69048217
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69048217
94negative regulation of protein localization to cell surface (GO:2000009)2.68982042
95cilium or flagellum-dependent cell motility (GO:0001539)2.68146821
96axoneme assembly (GO:0035082)2.68102532
97Golgi transport vesicle coating (GO:0048200)2.67184350
98COPI coating of Golgi vesicle (GO:0048205)2.67184350
99regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66706912
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.66706912
101DNA damage response, detection of DNA damage (GO:0042769)2.65823520
102cranial nerve morphogenesis (GO:0021602)2.65350545
103astrocyte development (GO:0014002)2.65176937
104positive regulation of endothelial cell apoptotic process (GO:2000353)2.64246365
105peripheral nervous system axon ensheathment (GO:0032292)2.63698901
106myelination in peripheral nervous system (GO:0022011)2.63698901
107forebrain neuron differentiation (GO:0021879)2.63193607
108positive regulation of cellular amine metabolic process (GO:0033240)2.62319716
109C-terminal protein lipidation (GO:0006501)2.61234287
110mitotic G2/M transition checkpoint (GO:0044818)2.60768621
111protein K11-linked deubiquitination (GO:0035871)2.60558468
112negative regulation of myoblast differentiation (GO:0045662)2.60157015
113regulation of transforming growth factor beta2 production (GO:0032909)2.59492131
114cellular response to hepatocyte growth factor stimulus (GO:0035729)2.58997800
115response to hepatocyte growth factor (GO:0035728)2.58997800
116sympathetic nervous system development (GO:0048485)2.58292338
117positive regulation of developmental pigmentation (GO:0048087)2.56809397
118chondrocyte proliferation (GO:0035988)2.55495634
119neuron recognition (GO:0008038)2.55483892
120regulation of sister chromatid segregation (GO:0033045)2.54882170
121regulation of mitotic sister chromatid separation (GO:0010965)2.54882170
122regulation of mitotic sister chromatid segregation (GO:0033047)2.54882170
123microtubule depolymerization (GO:0007019)2.54104929
124phenol-containing compound biosynthetic process (GO:0046189)2.53232941
125regulation of cilium movement (GO:0003352)2.53178332
126negative regulation of protein localization to plasma membrane (GO:1903077)2.52424531
127positive regulation of hormone biosynthetic process (GO:0046886)2.52403371
128regulation of Rac protein signal transduction (GO:0035020)2.51263385
129osteoclast differentiation (GO:0030316)2.50657499
130sterol biosynthetic process (GO:0016126)2.50184898
131negative regulation of mitotic sister chromatid separation (GO:2000816)2.50062563
132negative regulation of sister chromatid segregation (GO:0033046)2.50062563
133negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.50062563
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.50062563
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50062563
136cell proliferation in forebrain (GO:0021846)2.49843140
137cilium assembly (GO:0042384)2.49791492
138mitotic metaphase plate congression (GO:0007080)2.49507730
139positive regulation of synapse assembly (GO:0051965)2.49194923
140neuron remodeling (GO:0016322)2.48958688
141embryonic foregut morphogenesis (GO:0048617)2.48776691
142positive regulation of actin filament depolymerization (GO:0030836)2.48148335
143activated T cell proliferation (GO:0050798)2.46747991
144mitotic G2 DNA damage checkpoint (GO:0007095)2.46457152
145negative regulation of chromosome segregation (GO:0051985)2.46331568
146hypotonic response (GO:0006971)2.46271339
147motile cilium assembly (GO:0044458)2.46000996
148positive regulation of chromosome segregation (GO:0051984)2.45816132
149positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.45272597
150cell differentiation in spinal cord (GO:0021515)2.44884705
151cilium organization (GO:0044782)2.44246242
152negative regulation of chondrocyte differentiation (GO:0032331)2.44138372
153pigmentation (GO:0043473)2.43875915
154negative regulation of axon extension (GO:0030517)2.43381210
155retina layer formation (GO:0010842)2.42562532
156regulation of chromosome segregation (GO:0051983)2.42548076
157regulation of gene silencing by RNA (GO:0060966)2.41992130
158regulation of posttranscriptional gene silencing (GO:0060147)2.41992130
159regulation of gene silencing by miRNA (GO:0060964)2.41992130
160photoreceptor cell maintenance (GO:0045494)2.41557347
161protein localization to endosome (GO:0036010)2.40204120
162sperm-egg recognition (GO:0035036)2.39873250
163transmission of nerve impulse (GO:0019226)2.39648340
164import into cell (GO:0098657)2.39484830
165regulation of execution phase of apoptosis (GO:1900117)2.39115433
166amyloid precursor protein metabolic process (GO:0042982)2.38650544
167cell migration involved in sprouting angiogenesis (GO:0002042)2.38607790
168retina vasculature morphogenesis in camera-type eye (GO:0061299)2.37756160
169regulation of meiosis I (GO:0060631)2.36994660
170regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36742390
171spindle checkpoint (GO:0031577)2.36649255
172mitotic spindle checkpoint (GO:0071174)2.35708427
173nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.34146482
174regulation of chromatin silencing (GO:0031935)2.34004802
175establishment of integrated proviral latency (GO:0075713)2.33160138
176mRNA modification (GO:0016556)2.31831477
177mitotic spindle assembly checkpoint (GO:0007094)2.31776819
178anterior/posterior axis specification, embryo (GO:0008595)2.30903028
179oocyte development (GO:0048599)2.30866576
180histone lysine demethylation (GO:0070076)2.29978362
181hippo signaling (GO:0035329)2.27423800
182hyaluronan catabolic process (GO:0030214)2.27280831
183apoptotic cell clearance (GO:0043277)2.27187969
184regulation of nucleobase-containing compound transport (GO:0032239)2.25395707
185endodermal cell differentiation (GO:0035987)2.25366401
186regulation of early endosome to late endosome transport (GO:2000641)2.25240839
187spindle assembly checkpoint (GO:0071173)2.24856365
188cellular response to arsenic-containing substance (GO:0071243)2.24800261
189positive regulation of catenin import into nucleus (GO:0035413)2.23691946
190glomerular visceral epithelial cell development (GO:0072015)2.23459699
191regulation of sister chromatid cohesion (GO:0007063)2.21406491
192metaphase plate congression (GO:0051310)2.21290044
193oligosaccharide catabolic process (GO:0009313)2.20364332
194definitive hemopoiesis (GO:0060216)2.19360304
195stress granule assembly (GO:0034063)2.19194745
196regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.16658166
197endoderm development (GO:0007492)2.15240800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.10694058
2EZH2_22144423_ChIP-Seq_EOC_Human4.00664582
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.91819322
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.87339124
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.85602547
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.74717091
7GBX2_23144817_ChIP-Seq_PC3_Human3.11861347
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.89184373
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.88130897
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.82000158
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78553531
12TAF15_26573619_Chip-Seq_HEK293_Human2.73646815
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71119542
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.67495122
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.49799669
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.48791701
17CLOCK_20551151_ChIP-Seq_293T_Human2.40744532
18AR_21909140_ChIP-Seq_LNCAP_Human2.39326245
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.36563634
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.36563634
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.36563634
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36298042
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29685399
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29305340
25VDR_22108803_ChIP-Seq_LS180_Human2.21278574
26SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.19346798
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.17675759
28FUS_26573619_Chip-Seq_HEK293_Human2.12974832
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11607903
30* FLI1_27457419_Chip-Seq_LIVER_Mouse2.07914090
31POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07567312
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.05952504
33ER_23166858_ChIP-Seq_MCF-7_Human2.05766052
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.04358455
35SALL4_18804426_ChIP-ChIP_XEN_Mouse2.03953884
36BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03153490
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00809586
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.97669269
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.93393807
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93390677
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91977928
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86052946
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84026498
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83596742
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.82394678
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79222216
47* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78993708
48* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76903357
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73998383
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72829542
51* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72791569
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72549954
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69661384
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68416103
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.67316185
56RNF2_27304074_Chip-Seq_NSC_Mouse1.67088685
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66764723
58BRD4_25478319_ChIP-Seq_HGPS_Human1.66698098
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64544352
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64414252
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61301535
62* NANOG_18555785_Chip-Seq_ESCs_Mouse1.61273429
63* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60897944
64P300_19829295_ChIP-Seq_ESCs_Human1.60865643
65* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60388923
66* NFE2_27457419_Chip-Seq_LIVER_Mouse1.56152569
67* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.53340543
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.51545273
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50746885
70* P300_18555785_Chip-Seq_ESCs_Mouse1.50349367
71* CMYC_18555785_Chip-Seq_ESCs_Mouse1.50252597
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.48786410
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48450014
74* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47005671
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45352529
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.45275324
77* P53_22387025_ChIP-Seq_ESCs_Mouse1.44839874
78IRF1_19129219_ChIP-ChIP_H3396_Human1.44405861
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43280293
80* E2F1_18555785_Chip-Seq_ESCs_Mouse1.42258281
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39955484
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.39363717
83* STAT3_18555785_Chip-Seq_ESCs_Mouse1.38283145
84* EZH2_27294783_Chip-Seq_NPCs_Mouse1.37604428
85* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36898019
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35804357
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35300965
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.34069147
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32660672
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.32388265
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31647237
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31357611
93* NMYC_18555785_Chip-Seq_ESCs_Mouse1.29665636
94EWS_26573619_Chip-Seq_HEK293_Human1.27842030
95* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.26852903
96BP1_19119308_ChIP-ChIP_Hs578T_Human1.26439333
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26161203
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26161203
99TFEB_21752829_ChIP-Seq_HELA_Human1.25982200
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.25458044
101* OCT4_18555785_Chip-Seq_ESCs_Mouse1.25279691
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25265342
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24908558
104EED_16625203_ChIP-ChIP_MESCs_Mouse1.24396187
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24187652
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24101364
107* KLF4_18555785_Chip-Seq_ESCs_Mouse1.24022770
108* SOX2_18555785_Chip-Seq_ESCs_Mouse1.23953911
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22986169
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22942912
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20976304
112EZH2_27294783_Chip-Seq_ESCs_Mouse1.20330658
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20286558
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.20251469
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19003035
116IRF8_21731497_ChIP-ChIP_J774_Mouse1.18999831
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18560073
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18560073
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18356535
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18100099
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17680358
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17427018
123ZNF274_21170338_ChIP-Seq_K562_Hela1.14762461
124* ZFX_18555785_Chip-Seq_ESCs_Mouse1.13570022
125SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11588330
126RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11518987
127PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10920767
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10579748
129TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10446086
130SMAD4_21799915_ChIP-Seq_A2780_Human1.10277614
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09935937
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09788172
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09504471
134* PU1_27457419_Chip-Seq_LIVER_Mouse1.09203911
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09126541
136IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08700042
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08388897
138VDR_24787735_ChIP-Seq_THP-1_Human1.08295047
139GATA2_21666600_ChIP-Seq_HMVEC_Human1.07968309
140* CRX_20693478_ChIP-Seq_RETINA_Mouse1.07061197
141FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06696213
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06428767
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06428767
144* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05577115
145SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05109428
146ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05024258
147NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04522868
148TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04498814
149* CTCF_18555785_Chip-Seq_ESCs_Mouse1.04490907
150SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03406041
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03130415
152SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02915932
153KDM2B_26808549_Chip-Seq_REH_Human1.02626414
154CJUN_26792858_Chip-Seq_BT549_Human1.02291191
155* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02068340
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02020200
157* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01941862
158FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00773887
159TCF4_18268006_ChIP-ChIP_LS174T_Human1.00497966
160RUNX2_22187159_ChIP-Seq_PCA_Human1.00457088
161IGF1R_20145208_ChIP-Seq_DFB_Human1.00363565
162FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00258537
163EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99030546
164TP53_16413492_ChIP-PET_HCT116_Human0.98637826
165TP53_18474530_ChIP-ChIP_U2OS_Human0.98565299
166SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97770553
167* PU_27001747_Chip-Seq_BMDM_Mouse0.97348075
168FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96666685
169ELK1_19687146_ChIP-ChIP_HELA_Human0.96333178
170PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95198691
171SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95123105
172SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93958661
173TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93663627
174CDX2_22108803_ChIP-Seq_LS180_Human0.91731668
175* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91078978
176SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90722358
177TP63_23658742_ChIP-Seq_EP156T_Human0.90388323
178NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90385882
179NANOG_16153702_ChIP-ChIP_HESCs_Human0.88700030
180ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87901694
181TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87894852
182TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87346314
183* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87341656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.10974595
2MP0005171_absent_coat_pigmentation3.90862728
3MP0006054_spinal_hemorrhage3.68436775
4MP0010352_gastrointestinal_tract_polyps3.55738276
5MP0008438_abnormal_cutaneous_collagen3.45714701
6MP0005409_darkened_coat_color3.34286472
7MP0003880_abnormal_central_pattern3.32371904
8MP0004381_abnormal_hair_follicle3.22451923
9MP0001188_hyperpigmentation3.21950439
10MP0000372_irregular_coat_pigmentation3.04869373
11MP0005410_abnormal_fertilization3.00909135
12MP0000015_abnormal_ear_pigmentation2.99698523
13MP0009379_abnormal_foot_pigmentation2.96660435
14MP0003941_abnormal_skin_development2.86029077
15MP0008057_abnormal_DNA_replication2.69511078
16MP0000920_abnormal_myelination2.59684325
17MP0003705_abnormal_hypodermis_morpholog2.44852593
18MP0002877_abnormal_melanocyte_morpholog2.43377268
19MP0002102_abnormal_ear_morphology2.41835996
20MP0000566_synostosis2.39810667
21MP0005174_abnormal_tail_pigmentation2.33399582
22MP0001905_abnormal_dopamine_level2.32064330
23MP0009384_cardiac_valve_regurgitation2.29302799
24MP0005075_abnormal_melanosome_morpholog2.25594305
25MP0004742_abnormal_vestibular_system2.24943185
26MP0006292_abnormal_olfactory_placode2.22328963
27MP0002009_preneoplasia2.16279039
28MP0003566_abnormal_cell_adhesion2.14635774
29MP0000778_abnormal_nervous_system2.12703809
30MP0003938_abnormal_ear_development2.07795088
31MP0001485_abnormal_pinna_reflex2.05831789
32MP0003890_abnormal_embryonic-extraembry2.04046334
33MP0005408_hypopigmentation1.99418519
34MP0002938_white_spotting1.98824390
35MP0000569_abnormal_digit_pigmentation1.95153810
36MP0006276_abnormal_autonomic_nervous1.94798841
37MP0003172_abnormal_lysosome_physiology1.91156445
38MP0003950_abnormal_plasma_membrane1.83874418
39MP0001915_intracranial_hemorrhage1.82162142
40MP0010234_abnormal_vibrissa_follicle1.79585794
41MP0010368_abnormal_lymphatic_system1.78291616
42MP0003091_abnormal_cell_migration1.78191313
43MP0005275_abnormal_skin_tensile1.68367985
44MP0001529_abnormal_vocalization1.65212418
45MP0001849_ear_inflammation1.64416777
46MP0008007_abnormal_cellular_replicative1.62816642
47MP0004142_abnormal_muscle_tone1.59054563
48MP0001486_abnormal_startle_reflex1.56506182
49MP0005423_abnormal_somatic_nervous1.54846743
50MP0000371_diluted_coat_color1.53348531
51MP0002095_abnormal_skin_pigmentation1.51253031
52MP0003300_gastrointestinal_ulcer1.49881326
53MP0004885_abnormal_endolymph1.47753753
54MP0002254_reproductive_system_inflammat1.42260308
55MP0002177_abnormal_outer_ear1.42204335
56MP0008789_abnormal_olfactory_epithelium1.41602665
57MP0001730_embryonic_growth_arrest1.41568791
58MP0002751_abnormal_autonomic_nervous1.37999343
59MP0008260_abnormal_autophagy1.37774076
60MP0000026_abnormal_inner_ear1.37761156
61MP0005058_abnormal_lysosome_morphology1.36730961
62MP0005645_abnormal_hypothalamus_physiol1.36321712
63MP0003690_abnormal_glial_cell1.35215705
64MP0000767_abnormal_smooth_muscle1.35208375
65MP0001293_anophthalmia1.34992668
66MP0003077_abnormal_cell_cycle1.33489414
67MP0002272_abnormal_nervous_system1.32130656
68MP0010307_abnormal_tumor_latency1.29319540
69MP0005551_abnormal_eye_electrophysiolog1.29122098
70MP0004270_analgesia1.28626898
71MP0001963_abnormal_hearing_physiology1.26227009
72MP0003303_peritoneal_inflammation1.25896718
73MP0010030_abnormal_orbit_morphology1.25535329
74MP0003453_abnormal_keratinocyte_physiol1.23908518
75MP0003279_aneurysm1.23544996
76MP0001986_abnormal_taste_sensitivity1.21747537
77MP0006072_abnormal_retinal_apoptosis1.21061570
78MP0003634_abnormal_glial_cell1.20835775
79MP0003656_abnormal_erythrocyte_physiolo1.20412364
80MP0006082_CNS_inflammation1.20249143
81MP0004133_heterotaxia1.19071703
82MP0000462_abnormal_digestive_system1.18592370
83MP0005076_abnormal_cell_differentiation1.18588240
84MP0003111_abnormal_nucleus_morphology1.18329112
85MP0005023_abnormal_wound_healing1.16235798
86MP0001984_abnormal_olfaction1.15998430
87MP0000631_abnormal_neuroendocrine_gland1.15755512
88MP0003878_abnormal_ear_physiology1.15073596
89MP0005377_hearing/vestibular/ear_phenot1.15073596
90MP0003937_abnormal_limbs/digits/tail_de1.15015361
91MP0004957_abnormal_blastocyst_morpholog1.15002441
92MP0010094_abnormal_chromosome_stability1.14694632
93MP0002998_abnormal_bone_remodeling1.14094661
94MP0000049_abnormal_middle_ear1.14082966
95MP0000350_abnormal_cell_proliferation1.12991014
96MP0001324_abnormal_eye_pigmentation1.10900304
97MP0002092_abnormal_eye_morphology1.10432942
98MP0003698_abnormal_male_reproductive1.10132378
99MP0002638_abnormal_pupillary_reflex1.09867212
100MP0002006_tumorigenesis1.09522100
101MP0008932_abnormal_embryonic_tissue1.09163464
102MP0002277_abnormal_respiratory_mucosa1.08252865
103MP0002752_abnormal_somatic_nervous1.07961305
104MP0005394_taste/olfaction_phenotype1.05989188
105MP0005499_abnormal_olfactory_system1.05989188
106MP0004808_abnormal_hematopoietic_stem1.05948555
107MP0001672_abnormal_embryogenesis/_devel1.05645409
108MP0005380_embryogenesis_phenotype1.05645409
109MP0002734_abnormal_mechanical_nocicepti1.05116539
110MP0003693_abnormal_embryo_hatching1.04425973
111MP0002084_abnormal_developmental_patter1.02967955
112MP0008995_early_reproductive_senescence1.02371443
113MP0002139_abnormal_hepatobiliary_system1.02328583
114MP0005253_abnormal_eye_physiology1.02077564
115MP0002086_abnormal_extraembryonic_tissu1.00246909
116MP0002166_altered_tumor_susceptibility0.98635380
117MP0009250_abnormal_appendicular_skeleto0.98238091
118MP0004134_abnormal_chest_morphology0.97097858
119MP0005248_abnormal_Harderian_gland0.96050126
120MP0005621_abnormal_cell_physiology0.95707222
121MP0005623_abnormal_meninges_morphology0.95490189
122MP0003448_altered_tumor_morphology0.95140187
123MP0000428_abnormal_craniofacial_morphol0.94717865
124MP0005195_abnormal_posterior_eye0.94118697
125MP0003984_embryonic_growth_retardation0.93486123
126MP0005197_abnormal_uvea_morphology0.92603989
127MP0003221_abnormal_cardiomyocyte_apopto0.91691655
128MP0002697_abnormal_eye_size0.91212429
129MP0002064_seizures0.90943217
130MP0002229_neurodegeneration0.90291342
131MP0005395_other_phenotype0.89391685
132MP0002088_abnormal_embryonic_growth/wei0.88760931
133MP0003828_pulmonary_edema0.88654012
134MP0002557_abnormal_social/conspecific_i0.86317177
135MP0001440_abnormal_grooming_behavior0.85405612
136MP0005257_abnormal_intraocular_pressure0.85364587
137MP0000762_abnormal_tongue_morphology0.85302221
138MP0002882_abnormal_neuron_morphology0.84921877
139MP0003191_abnormal_cellular_cholesterol0.84548235
140MP0002060_abnormal_skin_morphology0.84500545
141MP0003724_increased_susceptibility_to0.83416751
142MP0005464_abnormal_platelet_physiology0.83220947
143MP0009046_muscle_twitch0.80612945
144MP0003385_abnormal_body_wall0.80500434
145MP0002572_abnormal_emotion/affect_behav0.79123527
146MP0002085_abnormal_embryonic_tissue0.78761922
147MP0002067_abnormal_sensory_capabilities0.78746063
148MP0000490_abnormal_crypts_of0.78667724
149MP0002184_abnormal_innervation0.77524523
150MP0001502_abnormal_circadian_rhythm0.77400526
151MP0001958_emphysema0.77134432
152MP0000465_gastrointestinal_hemorrhage0.76674482
153MP0001929_abnormal_gametogenesis0.76583191
154MP0002075_abnormal_coat/hair_pigmentati0.76558680
155MP0009745_abnormal_behavioral_response0.75726146
156MP0001879_abnormal_lymphatic_vessel0.73791181
157MP0000432_abnormal_head_morphology0.73227671
158MP0005503_abnormal_tendon_morphology0.73218009
159MP0001177_atelectasis0.73196411
160MP0001614_abnormal_blood_vessel0.73169634
161MP0008877_abnormal_DNA_methylation0.72666837
162MP0003632_abnormal_nervous_system0.72469285
163MP0001697_abnormal_embryo_size0.72427282
164MP0002925_abnormal_cardiovascular_devel0.72189229
165MP0004043_abnormal_pH_regulation0.71783787
166MP0005384_cellular_phenotype0.70586055
167MP0002233_abnormal_nose_morphology0.70544665
168MP0002876_abnormal_thyroid_physiology0.70208377
169MP0002295_abnormal_pulmonary_circulatio0.70192950
170MP0004272_abnormal_basement_membrane0.67383858
171MP0001186_pigmentation_phenotype0.67293603
172MP0001299_abnormal_eye_distance/0.67174566
173MP0003699_abnormal_female_reproductive0.66711227
174MP0003718_maternal_effect0.65731790
175MP0000681_abnormal_thyroid_gland0.65012772
176MP0003755_abnormal_palate_morphology0.63632406
177MP0003861_abnormal_nervous_system0.60125440
178MP0002152_abnormal_brain_morphology0.59190988
179MP0000955_abnormal_spinal_cord0.58986167
180MP0009697_abnormal_copulation0.58399382
181MP0005391_vision/eye_phenotype0.57495224

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.61032007
2Absent/shortened dynein arms (HP:0200106)4.42882812
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.42882812
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.03940620
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.03940620
6Papillary thyroid carcinoma (HP:0002895)3.79411064
7Abnormal ciliary motility (HP:0012262)3.74676455
8Abnormal respiratory motile cilium physiology (HP:0012261)3.70496203
9Parakeratosis (HP:0001036)3.66066655
10Abnormal respiratory motile cilium morphology (HP:0005938)3.62089434
11Abnormal respiratory epithelium morphology (HP:0012253)3.62089434
12Protrusio acetabuli (HP:0003179)3.45772411
13Cervical subluxation (HP:0003308)3.36151771
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.33324120
15Premature rupture of membranes (HP:0001788)3.21860698
16Patchy hypopigmentation of hair (HP:0011365)3.21324136
17Myocardial infarction (HP:0001658)3.20446968
18White forelock (HP:0002211)3.12446231
19Renal Fanconi syndrome (HP:0001994)2.96005314
20Split foot (HP:0001839)2.94683423
213-Methylglutaconic aciduria (HP:0003535)2.86870626
22Cerebral hypomyelination (HP:0006808)2.74834801
23Increased hepatocellular lipid droplets (HP:0006565)2.74041184
24Neurofibrillary tangles (HP:0002185)2.68667106
25Abnormality of renal resorption (HP:0011038)2.68401593
26Leiomyosarcoma (HP:0100243)2.65988394
27Uterine leiomyosarcoma (HP:0002891)2.65988394
28Stomach cancer (HP:0012126)2.65228613
29Abnormality of the corticospinal tract (HP:0002492)2.64916182
30Tubulointerstitial nephritis (HP:0001970)2.60681329
31Transitional cell carcinoma of the bladder (HP:0006740)2.59258612
32Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.55356020
33Retinal dysplasia (HP:0007973)2.54716190
34Thyroid carcinoma (HP:0002890)2.52689711
35Malignant gastrointestinal tract tumors (HP:0006749)2.52105406
36Gastrointestinal carcinoma (HP:0002672)2.52105406
37Alacrima (HP:0000522)2.49817868
38Hypothermia (HP:0002045)2.48356565
39Medial flaring of the eyebrow (HP:0010747)2.47094882
40Abnormality of the septum pellucidum (HP:0007375)2.46143009
41Absent septum pellucidum (HP:0001331)2.46109584
42Biconcave vertebral bodies (HP:0004586)2.42746361
43Arterial tortuosity (HP:0005116)2.42263978
44Bladder neoplasm (HP:0009725)2.41166893
45Bladder carcinoma (HP:0002862)2.41166893
46Wide nose (HP:0000445)2.40253129
47Hypoplasia of the fovea (HP:0007750)2.39674806
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.39674806
49Vascular tortuosity (HP:0004948)2.39318999
50Rhinitis (HP:0012384)2.39086513
51Adrenal hypoplasia (HP:0000835)2.38344230
52Septo-optic dysplasia (HP:0100842)2.37176147
53Prolonged neonatal jaundice (HP:0006579)2.37158075
54Flared iliac wings (HP:0002869)2.36669310
55Aortic dissection (HP:0002647)2.35767240
56Peripheral hypomyelination (HP:0007182)2.34594404
57Spastic diplegia (HP:0001264)2.34410830
58Ankle contracture (HP:0006466)2.33762283
59Hypomagnesemia (HP:0002917)2.33742605
60Sensory axonal neuropathy (HP:0003390)2.33395548
61Ankyloglossia (HP:0010296)2.33280437
62Congenital sensorineural hearing impairment (HP:0008527)2.33014891
63Hematochezia (HP:0002573)2.32192994
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31760580
65Capillary hemangiomas (HP:0005306)2.30466564
66Decreased lacrimation (HP:0000633)2.29157672
67Abnormality of midbrain morphology (HP:0002418)2.28923262
68Molar tooth sign on MRI (HP:0002419)2.28923262
69Type I transferrin isoform profile (HP:0003642)2.28452133
70Optic disc pallor (HP:0000543)2.26933590
71Abnormality of magnesium homeostasis (HP:0004921)2.24220400
72Syringomyelia (HP:0003396)2.24015019
73Spinal cord lesions (HP:0100561)2.24015019
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23689659
75Pancreatic fibrosis (HP:0100732)2.23402246
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.22654234
77Osteolytic defects of the hand bones (HP:0009699)2.22654234
78True hermaphroditism (HP:0010459)2.22529988
79Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22132306
80Humeroradial synostosis (HP:0003041)2.20969826
81Synostosis involving the elbow (HP:0003938)2.20969826
82Acute necrotizing encephalopathy (HP:0006965)2.20132593
83Deep philtrum (HP:0002002)2.19693102
84Nephroblastoma (Wilms tumor) (HP:0002667)2.18791796
85Gait imbalance (HP:0002141)2.18162772
86Lipid accumulation in hepatocytes (HP:0006561)2.17272406
87Asymmetry of the thorax (HP:0001555)2.15009258
88Nephronophthisis (HP:0000090)2.14618171
89Dilatation of the ascending aorta (HP:0005111)2.12293347
90Embryonal renal neoplasm (HP:0011794)2.11569892
91Abnormality of oral frenula (HP:0000190)2.09150204
92Limb dystonia (HP:0002451)2.07868974
93Mitochondrial inheritance (HP:0001427)2.07507805
94Aortic aneurysm (HP:0004942)2.07291316
95Genital tract atresia (HP:0001827)2.06925118
96Pancreatic cysts (HP:0001737)2.06401131
97Vaginal atresia (HP:0000148)2.06129090
98Abnormality of the axillary hair (HP:0100134)2.05730490
99Abnormality of secondary sexual hair (HP:0009888)2.05730490
100Nonprogressive disorder (HP:0003680)2.05271834
101Disinhibition (HP:0000734)2.03202524
102Esophageal varix (HP:0002040)2.03038157
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00698786
104Cortical dysplasia (HP:0002539)2.00049501
105Hand muscle atrophy (HP:0009130)1.99702681
106Nasolacrimal duct obstruction (HP:0000579)1.99612842
107Optic nerve hypoplasia (HP:0000609)1.99122300
108Tetraparesis (HP:0002273)1.99076130
109Abnormal hair whorl (HP:0010721)1.97301364
110Congenital ichthyosiform erythroderma (HP:0007431)1.97072603
111Flat acetabular roof (HP:0003180)1.96766014
112Mitral valve prolapse (HP:0001634)1.96023755
113Supernumerary spleens (HP:0009799)1.95965981
114Hypoplasia of the iris (HP:0007676)1.95814829
115Congenital malformation of the right heart (HP:0011723)1.94788602
116Double outlet right ventricle (HP:0001719)1.94788602
117Congenital primary aphakia (HP:0007707)1.94325125
118Shallow orbits (HP:0000586)1.94067037
119Conjunctival telangiectasia (HP:0000524)1.93608363
120Abnormality of the renal medulla (HP:0100957)1.92909324
121Periodontitis (HP:0000704)1.92209610
122Freckling (HP:0001480)1.91224071
123Abnormal auditory evoked potentials (HP:0006958)1.90634425
124Renal cell carcinoma (HP:0005584)1.89930429
125Aplasia/hypoplasia of the uterus (HP:0008684)1.88845523
126Rhabdomyosarcoma (HP:0002859)1.87793952
127Upper motor neuron abnormality (HP:0002127)1.86741303
128Abnormality of glycolipid metabolism (HP:0010969)1.86042043
129Abnormality of liposaccharide metabolism (HP:0010968)1.86042043
130Abnormality of glycosphingolipid metabolism (HP:0004343)1.86042043
131Preaxial hand polydactyly (HP:0001177)1.85802697
132Abnormality of the fovea (HP:0000493)1.85245668
133Wormian bones (HP:0002645)1.85139144
134Aortic valve stenosis (HP:0001650)1.84782735
135Progressive macrocephaly (HP:0004481)1.84685466
136Morphological abnormality of the inner ear (HP:0011390)1.84517168
137Aplasia cutis congenita (HP:0001057)1.83996072
138Nephrogenic diabetes insipidus (HP:0009806)1.83944490
139Lower limb hyperreflexia (HP:0002395)1.83551783
140Anteriorly placed anus (HP:0001545)1.83509566
141Abnormal foot bone ossification (HP:0010675)1.83136290
142Albinism (HP:0001022)1.82847055
143Abnormality of incisor morphology (HP:0011063)1.82761693
144Anencephaly (HP:0002323)1.81565773
145Osteomalacia (HP:0002749)1.80897692
146Vertebral compression fractures (HP:0002953)1.80130985
147Cupped ear (HP:0000378)1.79042869
148Aplasia/Hypoplasia of the tibia (HP:0005772)1.78603291
149Esophageal atresia (HP:0002032)1.78173565
150Hypopigmentation of the fundus (HP:0007894)1.77611778
151Pelvic girdle muscle weakness (HP:0003749)1.77564645
152Gonadotropin excess (HP:0000837)1.77533864
153Esotropia (HP:0000565)1.77471902
154Vertebral arch anomaly (HP:0008438)1.77418998
155Abnormality of the musculature of the pelvis (HP:0001469)1.76739895
156Abnormality of the hip-girdle musculature (HP:0001445)1.76739895
157Heterotopia (HP:0002282)1.75561777
158Abnormality of the acetabulum (HP:0003170)1.75358232
159Uterine neoplasm (HP:0010784)1.75254267
160Loss of speech (HP:0002371)1.75072762
161Intrahepatic cholestasis (HP:0001406)1.74724724
162Broad palm (HP:0001169)1.74710949
163Aplasia/Hypoplasia affecting the retina (HP:0008061)1.74483117
164Postaxial foot polydactyly (HP:0001830)1.74259823
165Aplasia/Hypoplasia of the lens (HP:0008063)1.73380106
166Abnormality of the common coagulation pathway (HP:0010990)1.73365709
167Duplicated collecting system (HP:0000081)1.73103329
168Partial duplication of thumb phalanx (HP:0009944)1.72645794
169Subacute progressive viral hepatitis (HP:0006572)1.72484854
170Decreased central vision (HP:0007663)1.71726598
171Abnormality of the intrinsic pathway (HP:0010989)1.71673621
172Scanning speech (HP:0002168)1.71532112
173Mucopolysacchariduria (HP:0008155)1.71242266
174Urinary glycosaminoglycan excretion (HP:0003541)1.71242266
175Abnormality of molar morphology (HP:0011070)1.70129351
176Abnormality of molar (HP:0011077)1.70129351
177Blue irides (HP:0000635)1.69007621
178Stage 5 chronic kidney disease (HP:0003774)1.68838119
179Aplasia/Hypoplasia of the macula (HP:0008059)1.68833752
180Abnormality of the nasolacrimal system (HP:0000614)1.68346326
181Morphological abnormality of the middle ear (HP:0008609)1.68231339
182Shoulder girdle muscle weakness (HP:0003547)1.68108140
183Biliary tract neoplasm (HP:0100574)1.66081805
184Increased mean platelet volume (HP:0011877)1.65421402
185Absent frontal sinuses (HP:0002688)1.62978785
186Menstrual irregularities (HP:0000858)1.62552632
187Soft skin (HP:0000977)1.62528966
188Pulmonic stenosis (HP:0001642)1.58162612
189Fatigue (HP:0012378)1.57334157
190Selective tooth agenesis (HP:0001592)1.57153350
191Distal upper limb amyotrophy (HP:0007149)1.56367822
192Upper limb amyotrophy (HP:0009129)1.56367822
193Acute myeloid leukemia (HP:0004808)1.54855637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.01900401
2TNIK3.87516357
3CASK3.82305704
4STK242.93790634
5NEK92.93014239
6TTK2.92727002
7PDGFRA2.70784293
8STK32.46593524
9OXSR12.45714501
10SRPK12.15163418
11MARK12.14131290
12LATS12.13477568
13WNK42.12403418
14STK38L2.09567753
15TAF12.04494781
16MAP3K142.01204900
17DDR21.98645885
18STK161.97837469
19PNCK1.97706305
20CDK121.95403216
21MAP3K131.95036555
22MUSK1.89398592
23MKNK11.87109582
24CDK61.83173058
25MAPKAPK51.81408599
26DYRK21.80545350
27FGFR41.76312877
28PKN11.75677184
29MAPK131.74506972
30EPHB11.73796468
31BCR1.71030449
32CDK91.70407664
33IRAK41.69474367
34BMPR1B1.65032054
35IRAK21.57172383
36CSNK1G31.55795444
37BRD41.55421955
38ZAK1.53549292
39ACVR1B1.53464935
40CSNK1A1L1.43895492
41IRAK11.43075746
42CSNK1G11.42376599
43MAPK151.39392073
44ADRBK21.37971905
45MKNK21.37811695
46CLK11.34771312
47CDC71.31112275
48MST41.31037847
49IRAK31.30641487
50YES11.29410895
51FGFR31.27447537
52AKT31.27273458
53BRSK21.26262651
54PLK31.25362441
55UHMK11.23032707
56KSR21.22579730
57WEE11.22235259
58NEK61.18651683
59LATS21.18525206
60MAP3K101.15273136
61CAMK2B1.11414605
62FLT31.10316506
63INSRR1.10040724
64PBK1.10033352
65ERBB41.09800552
66CSNK1G21.09760480
67PDGFRB1.09157392
68TGFBR21.08903593
69GRK71.06524574
70KSR11.05380500
71EPHA21.04153681
72TLK11.03809327
73FGFR11.03562364
74TYRO31.00275250
75MAP3K90.99364188
76JAK30.97352547
77FGFR20.97240969
78TRIM280.95684752
79MELK0.94082809
80MET0.92846345
81BRAF0.90960541
82DYRK30.90764027
83MATK0.89746870
84PTK20.89730044
85WNK10.88098714
86WNK30.88033265
87SGK4940.87064115
88SGK2230.87064115
89NLK0.86935370
90LIMK10.85869716
91EGFR0.85768168
92MAP2K70.85178547
93CDK30.84599234
94TTN0.84368676
95TYK20.83521981
96RPS6KA50.82739793
97BLK0.82088267
98FGR0.81845729
99EEF2K0.81297973
100ROCK20.80889048
101MAP3K80.80760953
102EIF2AK20.80580736
103NTRK20.80176563
104TSSK60.79996953
105CAMK2D0.79694513
106EIF2AK30.75789611
107VRK10.73322981
108PAK20.73125131
109MOS0.72033061
110PASK0.71986693
111JAK10.71380631
112PAK40.70435295
113TGFBR10.69962821
114PRKCE0.68793811
115RPS6KA40.68419215
116SGK30.67901015
117CDK70.64474644
118CDK190.64019486
119MAP3K60.62014929
120CAMK2A0.61410818
121PLK10.60663554
122NME10.60086450
123RIPK10.58960120
124EPHA30.58412144
125MAP2K20.57840890
126TRPM70.57754786
127CAMK1G0.56896700
128ATM0.56640491
129FES0.56594862
130GSK3A0.55935335
131GRK10.53866539
132NUAK10.53766170
133STK100.52962152
134MAPK70.52182757
135ERBB30.50207935
136TXK0.49874153
137CSK0.49561709
138CAMK2G0.48661047
139PAK30.48466300
140NEK20.45830035
141TIE10.45127880
142IGF1R0.44340822
143MAP3K40.43821224
144SGK20.42977992
145TEC0.41964141
146CAMK1D0.41781501
147CSF1R0.41076110
148CHEK10.41000393
149DYRK1B0.40983751
150FER0.40528933
151PDK20.40212946
152BMPR20.39769741
153ZAP700.39657820
154PRKG10.38765621
155HIPK20.38199877
156PRPF4B0.37062128
157DYRK1A0.36562185
158MARK20.35834250
159PIK3CG0.34488398
160CSNK1A10.33891749
161PAK10.32339726
162PRKD20.31136656
163PRKCQ0.30451494
164ROCK10.30155604
165KIT0.28384150
166PRKACA0.27509706
167MYLK0.26887080
168CSNK1E0.26782729
169ICK0.26777733
170CDK50.26449146
171CAMKK20.26220479
172SIK30.26031307
173PDK30.25756202

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.64736878
2Protein export_Homo sapiens_hsa030603.25776704
3Steroid biosynthesis_Homo sapiens_hsa001003.03227063
4Oxidative phosphorylation_Homo sapiens_hsa001902.97394881
5Ether lipid metabolism_Homo sapiens_hsa005652.86543040
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68764349
7Fatty acid elongation_Homo sapiens_hsa000622.54305395
8Adherens junction_Homo sapiens_hsa045202.27933415
9Sphingolipid metabolism_Homo sapiens_hsa006002.22443903
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16479154
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09857138
12Parkinsons disease_Homo sapiens_hsa050122.07472393
13Thyroid cancer_Homo sapiens_hsa052161.93956612
14RNA polymerase_Homo sapiens_hsa030201.84709965
15Cell cycle_Homo sapiens_hsa041101.83287677
16Alzheimers disease_Homo sapiens_hsa050101.80569774
17Huntingtons disease_Homo sapiens_hsa050161.79903436
18Proteasome_Homo sapiens_hsa030501.74184390
19Linoleic acid metabolism_Homo sapiens_hsa005911.73170917
20Arachidonic acid metabolism_Homo sapiens_hsa005901.72134837
21MicroRNAs in cancer_Homo sapiens_hsa052061.71523939
22Ribosome_Homo sapiens_hsa030101.68656339
23Axon guidance_Homo sapiens_hsa043601.59987310
24Proteoglycans in cancer_Homo sapiens_hsa052051.57086578
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56006249
26Collecting duct acid secretion_Homo sapiens_hsa049661.54988739
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49455926
28Basal transcription factors_Homo sapiens_hsa030221.48496593
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48001879
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47641869
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42178918
32Shigellosis_Homo sapiens_hsa051311.39997656
33Sulfur metabolism_Homo sapiens_hsa009201.37306653
34Chronic myeloid leukemia_Homo sapiens_hsa052201.36873355
35Small cell lung cancer_Homo sapiens_hsa052221.34752911
36Serotonergic synapse_Homo sapiens_hsa047261.33204948
37Vitamin B6 metabolism_Homo sapiens_hsa007501.32194773
38p53 signaling pathway_Homo sapiens_hsa041151.29984115
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23084147
40Rheumatoid arthritis_Homo sapiens_hsa053231.22591434
41Fanconi anemia pathway_Homo sapiens_hsa034601.21116765
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20995795
43Amoebiasis_Homo sapiens_hsa051461.20258940
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20027187
45Hepatitis B_Homo sapiens_hsa051611.19957173
46Graft-versus-host disease_Homo sapiens_hsa053321.19204943
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16971512
48Regulation of autophagy_Homo sapiens_hsa041401.16440701
49Focal adhesion_Homo sapiens_hsa045101.15424387
50Phototransduction_Homo sapiens_hsa047441.15204874
51Vibrio cholerae infection_Homo sapiens_hsa051101.12879986
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12559453
53Pancreatic cancer_Homo sapiens_hsa052121.11519677
54Viral carcinogenesis_Homo sapiens_hsa052031.09847368
55Colorectal cancer_Homo sapiens_hsa052101.09105666
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06902071
57TGF-beta signaling pathway_Homo sapiens_hsa043501.06684159
58Nicotine addiction_Homo sapiens_hsa050331.06112580
59Influenza A_Homo sapiens_hsa051641.06052189
60Other glycan degradation_Homo sapiens_hsa005111.06031818
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04468048
62Bladder cancer_Homo sapiens_hsa052191.03731900
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.02894761
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02261594
65Leukocyte transendothelial migration_Homo sapiens_hsa046701.01974595
66Osteoclast differentiation_Homo sapiens_hsa043801.01546324
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00778848
68TNF signaling pathway_Homo sapiens_hsa046680.99187328
69Leishmaniasis_Homo sapiens_hsa051400.98560362
70Phagosome_Homo sapiens_hsa041450.96947458
71Herpes simplex infection_Homo sapiens_hsa051680.96149892
72Glutathione metabolism_Homo sapiens_hsa004800.95775214
73B cell receptor signaling pathway_Homo sapiens_hsa046620.95626029
74Endometrial cancer_Homo sapiens_hsa052130.93711844
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93128543
76Hepatitis C_Homo sapiens_hsa051600.93010843
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91941851
78Homologous recombination_Homo sapiens_hsa034400.91675000
79Legionellosis_Homo sapiens_hsa051340.91219457
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91110399
81Non-homologous end-joining_Homo sapiens_hsa034500.90683342
82Histidine metabolism_Homo sapiens_hsa003400.89466516
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.89084243
84Selenocompound metabolism_Homo sapiens_hsa004500.88510131
85Lysine degradation_Homo sapiens_hsa003100.88077616
86Dorso-ventral axis formation_Homo sapiens_hsa043200.87778847
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87465578
88Complement and coagulation cascades_Homo sapiens_hsa046100.85985397
89Inositol phosphate metabolism_Homo sapiens_hsa005620.85717648
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84757821
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83878378
92Toxoplasmosis_Homo sapiens_hsa051450.83141810
93Pathways in cancer_Homo sapiens_hsa052000.82773469
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82597110
95Measles_Homo sapiens_hsa051620.81700969
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81651440
97Mismatch repair_Homo sapiens_hsa034300.80340799
98mRNA surveillance pathway_Homo sapiens_hsa030150.78690893
99Autoimmune thyroid disease_Homo sapiens_hsa053200.78417529
100Hippo signaling pathway_Homo sapiens_hsa043900.77172087
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.74409239
102Mineral absorption_Homo sapiens_hsa049780.74296545
103Spliceosome_Homo sapiens_hsa030400.73366288
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73114528
105Vitamin digestion and absorption_Homo sapiens_hsa049770.72018715
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71966666
107Pertussis_Homo sapiens_hsa051330.71924702
108Staphylococcus aureus infection_Homo sapiens_hsa051500.71740710
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71717111
110Long-term depression_Homo sapiens_hsa047300.71444938
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71317340
112Renin-angiotensin system_Homo sapiens_hsa046140.70478878
113RNA transport_Homo sapiens_hsa030130.69935873
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69693648
115Acute myeloid leukemia_Homo sapiens_hsa052210.69488830
116Retinol metabolism_Homo sapiens_hsa008300.68862978
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.68607952
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68019054
119HIF-1 signaling pathway_Homo sapiens_hsa040660.67985154
120Purine metabolism_Homo sapiens_hsa002300.67140369
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66446966
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.66143499
123Apoptosis_Homo sapiens_hsa042100.66103156
124Non-small cell lung cancer_Homo sapiens_hsa052230.65883441
125Cardiac muscle contraction_Homo sapiens_hsa042600.64411855
126FoxO signaling pathway_Homo sapiens_hsa040680.64300801
127Salmonella infection_Homo sapiens_hsa051320.64027875
128Protein digestion and absorption_Homo sapiens_hsa049740.63899661
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63705611
130Malaria_Homo sapiens_hsa051440.62781486
131Prolactin signaling pathway_Homo sapiens_hsa049170.62392746
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.61657654
133Metabolic pathways_Homo sapiens_hsa011000.61208486
134African trypanosomiasis_Homo sapiens_hsa051430.61068643
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.60768163
136Gap junction_Homo sapiens_hsa045400.60618742
137Pentose phosphate pathway_Homo sapiens_hsa000300.59770785
138Glutamatergic synapse_Homo sapiens_hsa047240.59453495
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59022222
140mTOR signaling pathway_Homo sapiens_hsa041500.58622514
141Tuberculosis_Homo sapiens_hsa051520.58506995
142Asthma_Homo sapiens_hsa053100.57815824
143Hedgehog signaling pathway_Homo sapiens_hsa043400.56597035
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56368727
145Allograft rejection_Homo sapiens_hsa053300.56295755
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55883611
147Pyrimidine metabolism_Homo sapiens_hsa002400.55522631
148Taste transduction_Homo sapiens_hsa047420.55350899
149Oocyte meiosis_Homo sapiens_hsa041140.54882616
150Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54398691
151ErbB signaling pathway_Homo sapiens_hsa040120.53858049
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53666872
153Rap1 signaling pathway_Homo sapiens_hsa040150.53657823
154HTLV-I infection_Homo sapiens_hsa051660.53647610
155Nucleotide excision repair_Homo sapiens_hsa034200.53023974
156Chemical carcinogenesis_Homo sapiens_hsa052040.51940796
157ECM-receptor interaction_Homo sapiens_hsa045120.51843375
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50467105
159N-Glycan biosynthesis_Homo sapiens_hsa005100.48761783
160Ras signaling pathway_Homo sapiens_hsa040140.47446876
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.46523401
162Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45256876
163Renal cell carcinoma_Homo sapiens_hsa052110.44907375
164Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43863367
165RNA degradation_Homo sapiens_hsa030180.43385933
166PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39388587
167Tight junction_Homo sapiens_hsa045300.39065103
168Wnt signaling pathway_Homo sapiens_hsa043100.38928777
169Lysosome_Homo sapiens_hsa041420.38843284
170Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38549148
171Morphine addiction_Homo sapiens_hsa050320.35567921
172Ovarian steroidogenesis_Homo sapiens_hsa049130.34150464
173Hematopoietic cell lineage_Homo sapiens_hsa046400.34104638
174Arginine and proline metabolism_Homo sapiens_hsa003300.33801348
175GABAergic synapse_Homo sapiens_hsa047270.33540815
176Prostate cancer_Homo sapiens_hsa052150.28196047
177Cocaine addiction_Homo sapiens_hsa050300.27021257
178Basal cell carcinoma_Homo sapiens_hsa052170.25367212
179Alcoholism_Homo sapiens_hsa050340.24201913
180Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24162041
181Butanoate metabolism_Homo sapiens_hsa006500.23830288

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